A B Maier

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. pmc Defining sarcopenia: the impact of different diagnostic criteria on the prevalence of sarcopenia in a large middle aged cohort
    A Y Bijlsma
    Department of Gerontology and Geriatrics, C2 R 133, Leiden University Medical Centre, P O Box 9600, 2300 RCLeiden, The Netherlands
    Age (Dordr) 35:871-81. 2013
  2. pmc CMV and Immunosenescence: from basics to clinics
    Rafael Solana
    Immunology Unit, Instituto Maimónides de Investigación Biomédica de Córdoba IMIBIC Reina Sofia University Hospital University of Cordoba, Cordoba, Spain
    Immun Ageing 9:23. 2012
  3. pmc The effect of chronological age on the inflammatory response of human fibroblasts
    Juliane Wolf
    Immunology Division, Institute for Biomedical Aging Research, Austrian Academy of Sciences, Rennweg 10, 6020 Innsbruck, Austria
    Exp Gerontol 47:749-53. 2012
  4. pmc Morphometric skin characteristics dependent on chronological and biological age: the Leiden Longevity Study
    Mariëtte E C Waaijer
    Department of Gerontology and Geriatrics, Leiden University Medical Center, The Netherlands
    Age (Dordr) 34:1543-52. 2012
  5. pmc Handgrip strength at midlife and familial longevity : The Leiden Longevity Study
    Carolina H Y Ling
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands
    Age (Dordr) 34:1261-8. 2012
  6. pmc Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study
    Sijia Chen
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, The Netherlands
    Immun Ageing 9:18. 2012
  7. doi Chronic inhibition of the respiratory chain in human fibroblast cultures: differential responses related to subject chronological and biological age
    Pim Dekker
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    J Gerontol A Biol Sci Med Sci 67:456-64. 2012
  8. pmc Regenerative potential of human muscle stem cells in chronic inflammation
    Bouke J Duijnisveld
    Department of Orthopaedics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Arthritis Res Ther 13:R207. 2011
  9. doi Human in vivo longevity is reflected in vitro by differential metabolism as measured by (1)H-NMR profiling of cell culture supernatants
    Pim Dekker
    Department of Gerontology and Geriatrics, Leiden University Medical Center, RC Leiden, The Netherlands
    Mol Biosyst 8:783-9. 2012
  10. ncbi Colony formation and colony size do not reflect the onset of replicative senescence in human fibroblasts
    Andrea B Maier
    Leiden University Medical Center, Department of Gerontology and Geriatrics, Leiden, The Netherlands
    J Gerontol A Biol Sci Med Sci 63:655-9. 2008

Collaborators

Detail Information

Publications31

  1. pmc Defining sarcopenia: the impact of different diagnostic criteria on the prevalence of sarcopenia in a large middle aged cohort
    A Y Bijlsma
    Department of Gerontology and Geriatrics, C2 R 133, Leiden University Medical Centre, P O Box 9600, 2300 RCLeiden, The Netherlands
    Age (Dordr) 35:871-81. 2013
    ..It is necessary to reach a consensus on the definition of sarcopenia in order to make studies comparable and for implementation in clinical care...
  2. pmc CMV and Immunosenescence: from basics to clinics
    Rafael Solana
    Immunology Unit, Instituto Maimónides de Investigación Biomédica de Córdoba IMIBIC Reina Sofia University Hospital University of Cordoba, Cordoba, Spain
    Immun Ageing 9:23. 2012
    ..Here we summarize the major findings of this workshop...
  3. pmc The effect of chronological age on the inflammatory response of human fibroblasts
    Juliane Wolf
    Immunology Division, Institute for Biomedical Aging Research, Austrian Academy of Sciences, Rennweg 10, 6020 Innsbruck, Austria
    Exp Gerontol 47:749-53. 2012
    ..It may thus contribute to age-related inflammatory processes, referred to as 'inflamm-aging'...
  4. pmc Morphometric skin characteristics dependent on chronological and biological age: the Leiden Longevity Study
    Mariëtte E C Waaijer
    Department of Gerontology and Geriatrics, Leiden University Medical Center, The Netherlands
    Age (Dordr) 34:1543-52. 2012
    ..Epidermal and elastic fibre morphometric characteristics are not a potential marker for familial longevity in middle-aged subjects enriched for familial longevity...
  5. pmc Handgrip strength at midlife and familial longevity : The Leiden Longevity Study
    Carolina H Y Ling
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands
    Age (Dordr) 34:1261-8. 2012
    ..This finding suggests that genetic component of susceptibility to extreme survival is likely to be separate from that of muscular strength...
  6. pmc Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study
    Sijia Chen
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, The Netherlands
    Immun Ageing 9:18. 2012
    ..abstract:..
  7. doi Chronic inhibition of the respiratory chain in human fibroblast cultures: differential responses related to subject chronological and biological age
    Pim Dekker
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    J Gerontol A Biol Sci Med Sci 67:456-64. 2012
    ..05). Strains from young and old subjects are differentially affected by chronic inhibition of the respiratory chain. Changed growth rates in strains from offspring resemble those from strains from young subjects...
  8. pmc Regenerative potential of human muscle stem cells in chronic inflammation
    Bouke J Duijnisveld
    Department of Orthopaedics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Arthritis Res Ther 13:R207. 2011
    ..The aim of this study was to define the role of chronic inflammation on the regenerative potential of satellite cells in human muscle...
  9. doi Human in vivo longevity is reflected in vitro by differential metabolism as measured by (1)H-NMR profiling of cell culture supernatants
    Pim Dekker
    Department of Gerontology and Geriatrics, Leiden University Medical Center, RC Leiden, The Netherlands
    Mol Biosyst 8:783-9. 2012
    ..In conclusion, differences in NMR-based metabolic profiles of human cells in vitro reflect the propensity for human longevity of the subjects from whom these were derived...
  10. ncbi Colony formation and colony size do not reflect the onset of replicative senescence in human fibroblasts
    Andrea B Maier
    Leiden University Medical Center, Department of Gerontology and Geriatrics, Leiden, The Netherlands
    J Gerontol A Biol Sci Med Sci 63:655-9. 2008
    ..The number of cells within the colonies was modestly correlated to the growth speed of the mass cultures. We conclude that the colony formation assay does not reflect the onset of replicative senescence in human fibroblasts...
  11. doi Relation between replicative senescence of human fibroblasts and life history characteristics
    Andrea B Maier
    Leiden University Medical Centre, Department of Gerontology and Geriatrics, 2300 RC Leiden, The Netherlands
    Ageing Res Rev 8:237-43. 2009
    ..018) indicating that publication bias is at play. We conclude that, except for premature ageing syndromes, replicative capacity of fibroblasts in vitro does not mirror key characteristics of human life histories...
  12. ncbi Combined medical-psychiatric inpatient units: evaluation of the Centre for the Elderly
    A B Maier
    Leiden University Medical Center, Department of Gerontology and Geriatrics, 9600, 2300 RC, Leiden, The Netherlands
    Z Gerontol Geriatr 40:268-74. 2007
    ..We conclude that interdisciplinary treatment between the departments of psychiatry and geriatric medicine may contribute to the medical needs of subgroups of elderly inpatients suffering from medical-psychiatric comorbidity...
  13. ncbi Beta-galactosidase activity as a biomarker of replicative senescence during the course of human fibroblast cultures
    Andrea B Maier
    Department of Gerontology and Geriatrics, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Ann N Y Acad Sci 1100:323-32. 2007
    ..Thus, our results support beta-galactosidase activity as a reliable biomarker for the course of replicative senescence, if used under defined standardized conditions...
  14. doi Proton magnetic resonance spectroscopy shows lower intramyocellular lipid accumulation in middle-aged subjects predisposed to familial longevity
    C A Wijsman
    Department of Gerontology and Geriatrics, Leiden University Medical Center, The Netherlands
    Am J Physiol Endocrinol Metab 302:E344-8. 2012
    ..Future research should focus on assessing what mechanisms may explain the lower IMCL levels in familial longevity...
  15. doi Rapid flow cytometric method for measuring senescence associated beta-galactosidase activity in human fibroblasts
    Gerard Noppe
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden 2300 RC, The Netherlands
    Cytometry A 75:910-6. 2009
    ..004 and P = 0.635 respectively). We found the modified flow cytometric method measuring SA-beta-gal activity superior in discriminating between degrees of senescence in different populations of fibroblasts...
  16. doi Chronology of age-related disease definitions: osteoporosis and sarcopenia
    A Y Bijlsma
    Department of Gerontology and Geriatrics, Leiden University Medical Centre, The Netherlands
    Ageing Res Rev 11:320-4. 2012
    ..Consensus must be reached regarding the diagnostic criteria to quantify muscle mass, correction factors, and reference populations used to define cut-off values of muscle mass...
  17. ncbi Persistence of high-replicative capacity in cultured fibroblasts from nonagenarians
    Andrea B Maier
    Department of Gerontology and Geriatrics, Leiden University Medical Centerm PO BOX 9600, 2300 RC Leiden, The Netherlands
    Aging Cell 6:27-33. 2007
    ..These results cast further doubt on the association between in vitro growth characteristics of fibroblast cultures and the length of human lifespan...
  18. pmc Homocysteine and familial longevity: the Leiden Longevity Study
    Carolien A Wijsman
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 6:e17543. 2011
    ..63). The results suggest that homocysteine metabolism is not likely to predict familial longevity...
  19. doi Handgrip strength as a predictor of functional, psychological and social health. A prospective population-based study among the oldest old
    Diana G Taekema
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Age Ageing 39:331-7. 2010
    ..Muscle strength measurements could be useful as part of a clinical evaluation of oldest old patients to determine who are most at risk of accelerated decline in the near future...
  20. doi Circulating levels of IGF1 are associated with muscle strength in middle-aged- and oldest-old women
    Diana G Taekema
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Endocrinol 164:189-96. 2011
    ..We studied the relationship between circulating levels of IGF1, its binding protein 3 (IGFBP3), and handgrip strength and physical performance in middle-aged- and oldest-old subjects...
  21. doi Higher blood pressure is associated with higher handgrip strength in the oldest old
    Diana G Taekema
    Department of Gerontology and Geriatrics, Leiden University Medical Center, The Netherlands
    Am J Hypertens 24:83-9. 2011
    ..It is unknown how BP associates with muscle function in oldest old people. We studied the association between BP and handgrip strength in middle and old age...
  22. doi Stress-induced responses of human skin fibroblasts in vitro reflect human longevity
    Pim Dekker
    Department of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Aging Cell 8:595-603. 2009
    ..008 and 0.004, respectively). These data provide strong support for the hypothesis that in vitro cellular responses to stress reflect the propensity for human longevity...
  23. pmc Handgrip strength and mortality in the oldest old population: the Leiden 85-plus study
    Carolina H Y Ling
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, Netherlands
    CMAJ 182:429-35. 2010
    ..However, the oldest old population (i.e., over 85 years) is underrepresented in such studies. Our objective was to assess the association between muscular strength and mortality in the oldest old population...
  24. doi Serum insulin-like growth factor 1 and facial ageing: high levels associate with reduced skin wrinkling in a cross-sectional study
    R Noordam
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands Unilever Discover, Colworth, Sharnbrook, Bedfordshire, UK
    Br J Dermatol 168:533-8. 2013
    ..Insulin-like growth factor (IGF)-1 is a growth factor that can influence fibroblast functioning, with effects including the inhibition of collagenases and the induction of collagen expression...
  25. doi Influence of the TP53 codon 72 polymorphism on the cellular responses to X-irradiation in fibroblasts from nonagenarians
    P Martijn den Reijer
    Department of Gerontology and Geriatrics, Leiden University Medical Centre, RC Leiden, The Netherlands
    Mech Ageing Dev 129:175-82. 2008
    ..029) at 3 days after irradiation. Possibly, these differences in cellular responses to stress between the TP53 codon 72 genotypes contribute to the differences in cancer incidence and longevity observed earlier for these genotypes...
  26. doi Impaired standing balance: the clinical need for closing the loop
    J H Pasma
    Department of Rehabilitation Medicine, Leiden University Medical Center, P O Box 2300, 9600 RC Leiden, The Netherlands
    Neuroscience 267:157-65. 2014
    ..Finally, a new approach to assess standing balance and to detect the underlying deteriorations is proposed. ..
  27. pmc Genomics of human longevity
    P E Slagboom
    Section of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Philos Trans R Soc Lond B Biol Sci 366:35-42. 2011
    ..By the integration of research in different study cohorts, and with research in animal models, biological research into human longevity is thus making considerable progress...
  28. doi Patterns of muscle strength loss with age in the general population and patients with a chronic inflammatory state
    Karel G M Beenakker
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Ageing Res Rev 9:431-6. 2010
    ..Handgrip strength was used as a proxy for overall muscle strength...
  29. doi Relation between maximum replicative capacity and oxidative stress-induced responses in human skin fibroblasts in vitro
    Pim Dekker
    Department of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    J Gerontol A Biol Sci Med Sci 66:45-50. 2011
    ..07). Summarizing, fibroblast strains with a higher maximum replicative capacity have longer telomeres, are less prone to go into stress-induced cellular senescence, and more prone to die after stress...
  30. doi An unopposed proinflammatory response is beneficial for survival in the oldest old. Results of the Leiden 85-plus Study
    Carolien A Wijsman
    Department of Gerontology and Geriatrics, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    J Gerontol A Biol Sci Med Sci 66:393-9. 2011
    ..50, 95% confidence interval: 0.26-0.96). In old age, the capacity to generate an unopposed proinflammatory innate immune response is predictive of long-term survival...
  31. ncbi Relation between body height and replicative capacity of human fibroblasts in nonagenarians
    Andrea B Maier
    J Gerontol A Biol Sci Med Sci 63:43-5. 2008