Johan Kuiper

Summary

Affiliation: Leiden University
Country: The Netherlands

Publications

  1. doi request reprint Effect of natural killer T cell activation on the initiation of atherosclerosis
    Gijs H M van Puijvelde
    Division of Biopharmaceutics, Gorlaeus Laboratories, Einsteinweg 55, 2300 RA Leiden, The Netherlands
    Thromb Haemost 102:223-30. 2009
  2. ncbi request reprint Immunomodulation of the inflammatory response in atherosclerosis
    Johan Kuiper
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands
    Curr Opin Lipidol 18:521-6. 2007
  3. ncbi request reprint Combined deletion of macrophage ABCA1 and ABCG1 leads to massive lipid accumulation in tissue macrophages and distinct atherosclerosis at relatively low plasma cholesterol levels
    Ruud Out
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Einsteinweg 55, 2333CC Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 28:258-64. 2008
  4. doi request reprint Interruption of the OX40-OX40 ligand pathway in LDL receptor-deficient mice causes regression of atherosclerosis
    Amanda C Foks
    Division of Biopharmaceutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden 2300 RA, The Netherlands
    J Immunol 191:4573-80. 2013
  5. pmc Leukocyte ABCA1 remains atheroprotective in splenectomized LDL receptor knockout mice
    Bart Lammers
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, Leiden, The Netherlands
    PLoS ONE 7:e48080. 2012
  6. doi request reprint Leukocyte-specific CCL3 deficiency inhibits atherosclerotic lesion development by affecting neutrophil accumulation
    Saskia C A de Jager
    Division of Biopharmaceutics, Leiden Academic Center for Drug Research, Gorlaeus Laboratories, Leiden University, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 33:e75-83. 2013
  7. doi request reprint Vaccination against TIE2 reduces atherosclerosis
    Arnaud D Hauer
    Division of Biopharmaceutics, Leiden University, 2333 CC, Leiden, The Netherlands
    Atherosclerosis 204:365-71. 2009
  8. pmc Lysophosphatidic acid triggers mast cell-driven atherosclerotic plaque destabilization by increasing vascular inflammation
    Martine Bot
    Division of Biopharmaceutics, Leiden Academic Centre for Drug Research, 2333 CC, Leiden University, Leiden, The Netherlands
    J Lipid Res 54:1265-74. 2013
  9. pmc Effects of deletion of macrophage ABCA7 on lipid metabolism and the development of atherosclerosis in the presence and absence of ABCA1
    Illiana Meurs
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, Leiden, The Netherlands
    PLoS ONE 7:e30984. 2012
  10. doi request reprint Macrophage ABCA2 deletion modulates intracellular cholesterol deposition, affects macrophage apoptosis, and decreases early atherosclerosis in LDL receptor knockout mice
    Laura Calpe-Berdiel
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, Einsteinweg 55, 2333CC Leiden, The Netherlands
    Atherosclerosis 223:332-41. 2012

Detail Information

Publications72

  1. doi request reprint Effect of natural killer T cell activation on the initiation of atherosclerosis
    Gijs H M van Puijvelde
    Division of Biopharmaceutics, Gorlaeus Laboratories, Einsteinweg 55, 2300 RA Leiden, The Netherlands
    Thromb Haemost 102:223-30. 2009
    ..This may be explained by the decreased presentation of lipids on CD1d molecules due to the lack of apoE. In this study we proved for the first time that NKT cells may also act in an atheroprotective manner...
  2. ncbi request reprint Immunomodulation of the inflammatory response in atherosclerosis
    Johan Kuiper
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands
    Curr Opin Lipidol 18:521-6. 2007
    ....
  3. ncbi request reprint Combined deletion of macrophage ABCA1 and ABCG1 leads to massive lipid accumulation in tissue macrophages and distinct atherosclerosis at relatively low plasma cholesterol levels
    Ruud Out
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Einsteinweg 55, 2333CC Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 28:258-64. 2008
    ..The purpose of this study was to evaluate the effect of the combined deletion of ABCA1 and ABCG1 expression in macrophages on foam cell formation and atherosclerosis...
  4. doi request reprint Interruption of the OX40-OX40 ligand pathway in LDL receptor-deficient mice causes regression of atherosclerosis
    Amanda C Foks
    Division of Biopharmaceutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden 2300 RA, The Netherlands
    J Immunol 191:4573-80. 2013
    ....
  5. pmc Leukocyte ABCA1 remains atheroprotective in splenectomized LDL receptor knockout mice
    Bart Lammers
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, Leiden, The Netherlands
    PLoS ONE 7:e48080. 2012
    ..In the present study, we aimed to explore the importance of the spleen for the atheroprotective effects of leukocyte ABCA1...
  6. doi request reprint Leukocyte-specific CCL3 deficiency inhibits atherosclerotic lesion development by affecting neutrophil accumulation
    Saskia C A de Jager
    Division of Biopharmaceutics, Leiden Academic Center for Drug Research, Gorlaeus Laboratories, Leiden University, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 33:e75-83. 2013
    ..It has recently been shown that under conditions of inflammation neutrophils can migrate along a CCL3 gradient. In this study, we aimed to elucidate the role of leukocyte-derived CCL3 in atherogenesis...
  7. doi request reprint Vaccination against TIE2 reduces atherosclerosis
    Arnaud D Hauer
    Division of Biopharmaceutics, Leiden University, 2333 CC, Leiden, The Netherlands
    Atherosclerosis 204:365-71. 2009
    ..TIE2(+) cells play a crucial role in processes that are involved in atherosclerosis, such as angiogenesis. Therefore, the specific deletion of TIE2(+) cells by means of DNA vaccination may affect atherosclerosis...
  8. pmc Lysophosphatidic acid triggers mast cell-driven atherosclerotic plaque destabilization by increasing vascular inflammation
    Martine Bot
    Division of Biopharmaceutics, Leiden Academic Centre for Drug Research, 2333 CC, Leiden University, Leiden, The Netherlands
    J Lipid Res 54:1265-74. 2013
    ..This study points to local LPA availability as an important factor in atherosclerotic plaque stability...
  9. pmc Effects of deletion of macrophage ABCA7 on lipid metabolism and the development of atherosclerosis in the presence and absence of ABCA1
    Illiana Meurs
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, Leiden, The Netherlands
    PLoS ONE 7:e30984. 2012
    ..Our data indicate that ABCA7 may play a role in T cell proliferation and erythropoeisis in spleen...
  10. doi request reprint Macrophage ABCA2 deletion modulates intracellular cholesterol deposition, affects macrophage apoptosis, and decreases early atherosclerosis in LDL receptor knockout mice
    Laura Calpe-Berdiel
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, Einsteinweg 55, 2333CC Leiden, The Netherlands
    Atherosclerosis 223:332-41. 2012
    ..It has been suggested that ABCA2 sequesters cholesterol inside the lysosomes, however, little is known of the macrophage-specific role of ABCA2 in regulating lipid homeostasis in vivo and in modulating susceptibility to atherosclerosis...
  11. pmc Macrophage adipose triglyceride lipase deficiency attenuates atherosclerotic lesion development in low-density lipoprotein receptor knockout mice
    Bart Lammers
    Division of Biopharmaceutics, Gorlaeus Laboratories, Einsteinweg 55, 2333CC Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 31:67-73. 2011
    ..Because ATGL knockout (KO) mice exhibit massive TG accumulation in macrophages, we used ATGL KO mice to study the effects of macrophage TG accumulation on atherogenesis...
  12. pmc Hematopoietic sphingosine 1-phosphate lyase deficiency decreases atherosclerotic lesion development in LDL-receptor deficient mice
    Martine Bot
    Division of Biopharmaceutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands
    PLoS ONE 8:e63360. 2013
    ..As S1P levels are tightly controlled by S1P lyase, we investigated the impact of hematopoietic S1P lyase (Sgpl1(-/-)) deficiency on leukocyte subsets relevant to atherosclerosis...
  13. doi request reprint The expression level of non-alcoholic fatty liver disease-related gene PNPLA3 in hepatocytes is highly influenced by hepatic lipid status
    Menno Hoekstra
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, Leiden, The Netherlands
    J Hepatol 52:244-51. 2010
    ..To gain insight into the potential function of PNPLA3 in liver, we have determined the effect of metabolic shifts on the hepatic expression profile of PNPLA3 in mice...
  14. doi request reprint Adenosine A₂B receptor agonism inhibits neointimal lesion development after arterial injury in apolipoprotein E-deficient mice
    Ilze Bot
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 32:2197-205. 2012
    ..Recently, it has been demonstrated that A(2B)R deficiency enhances neointimal lesion formation after vascular injury. Therefore, we hypothesize that A(2B)R agonism protects against injury-induced intimal hyperplasia...
  15. doi request reprint Vaccination using oxidized low-density lipoprotein-pulsed dendritic cells reduces atherosclerosis in LDL receptor-deficient mice
    Kim L L Habets
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, PO Box 9502, 2300 RA Leiden, The Netherlands
    Cardiovasc Res 85:622-30. 2010
    ..In this study, we transferred oxLDL-pulsed mature DCs (mDCs) to LDL receptor-null (LDLr(-/-)) mice and examined the effects on atherosclerosis...
  16. doi request reprint Vaccination against CD99 inhibits atherogenesis in low-density lipoprotein receptor-deficient mice
    Eva J A van Wanrooij
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, PO Box 9502, 2300 RA Leiden, The Netherlands
    Cardiovasc Res 78:590-6. 2008
    ..The aim of the present study is to show the role of CD99 in atherosclerosis using a CD99 vaccination protocol to block the function of CD99 during atherosclerosis...
  17. pmc Scavenger receptor class B type I-mediated uptake of serum cholesterol is essential for optimal adrenal glucocorticoid production
    Menno Hoekstra
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, 2300RA Leiden, The Netherlands
    J Lipid Res 50:1039-46. 2009
    ..In conclusion, we have shown that CETP-mediated transfer of HDL-CE is not able to reverse adrenal insufficiency in SR-BI knockout mice. Thus, SR-BI-mediated uptake of serum cholesterol is essential for optimal adrenal function...
  18. pmc Leukocytosis and enhanced susceptibility to endotoxemia but not atherosclerosis in adrenalectomized APOE knockout mice
    Menno Hoekstra
    Division of Biopharmaceutics, Leiden Academic Centre for Drug Research, Leiden, The Netherlands
    PLoS ONE 8:e80441. 2013
    ..The adrenalectomy-associated rise in white blood cells, however, does not alter atherosclerotic lesion development probably due to the parallel decrease in plasma levels of pro-atherogenic lipoproteins. ..
  19. doi request reprint T-cell immunoglobulin and mucin domain 3 acts as a negative regulator of atherosclerosis
    Amanda C Foks
    From the Division of Biopharmaceutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands A C F, I A R, L W, V F, M N D t B, S C A d J, P J v S, I B, J K, G H M v P Experimental Cardiology Laboratory, University Medical Center Utrecht, Utrecht, The Netherlands S C A d J and Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan H Y, H A
    Arterioscler Thromb Vasc Biol 33:2558-65. 2013
    ..In the present study, we determined the role of Tim-3 in the development of atherosclerosis...
  20. ncbi request reprint CXCR3 antagonist NBI-74330 attenuates atherosclerotic plaque formation in LDL receptor-deficient mice
    Eva J A van Wanrooij
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Leiden University, P O Box 9502, 2300 RA Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 28:251-7. 2008
    ..We used the CXCR3 specific antagonist NBI-74330 to block CXCR3-mediated signaling in peritonitis and diet-induced atherosclerosis...
  21. doi request reprint Interference of the CD30-CD30L pathway reduces atherosclerosis development
    Amanda C Foks
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 32:2862-8. 2012
    ..In the present study, we thus aimed to determine the role of the CD30-CD30L pathway in the development of atherosclerosis...
  22. doi request reprint Nonalcoholic fatty liver disease is associated with an altered hepatocyte microRNA profile in LDL receptor knockout mice
    Menno Hoekstra
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden, The Netherlands
    J Nutr Biochem 23:622-8. 2012
    ..Based upon our comparative gene and microRNA expression studies it is anticipated that miR-302a may prove to be a valuable therapeutic target in the regulation of hepatic fatty acid utilization and insulin resistance...
  23. ncbi request reprint Coexistence of foam cells and hypocholesterolemia in mice lacking the ABC transporters A1 and G1
    Ruud Out
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Leiden University, The Netherlands
    Circ Res 102:113-20. 2008
    ..In conclusion, even under hypocholesterolemic conditions macrophages can be converted into foam cells, and ABCA1 and ABCG1 play an essential role in the prevention of foam cell formation...
  24. ncbi request reprint Total body ABCG1 expression protects against early atherosclerotic lesion development in mice
    Ruud Out
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Einsteinweg 55, 2333CC Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 27:594-9. 2007
    ..To further define the role of ABCG1 in atherogenesis, we investigated in the current study the effect of total body deficiency of ABCG1 on atherosclerotic lesion development...
  25. doi request reprint IL-15 aggravates atherosclerotic lesion development in LDL receptor deficient mice
    Thomas van Es
    Division of Biopharmaceutics, LACDR, Leiden University, Leiden, The Netherlands
    Vaccine 29:976-83. 2011
    ..Interleukin 15 (IL-15) is a pro-inflammatory cytokine involved in inflammatory diseases and IL-15 is expressed in atherosclerotic plaques...
  26. doi request reprint CD11b+Gr-1+ myeloid-derived suppressor cells reduce atherosclerotic lesion development in LDLr deficient mice
    Amanda C Foks
    Division of Biopharmaceutics, Leiden University, Gorlaeus Laboratories, Einsteinweg 55, Leiden 2333 CC, The Netherlands
    Cardiovasc Res 111:252-61. 2016
    ..Here, we investigated whether and how MDSCs contribute to the development of atherosclerosis...
  27. doi request reprint Oxidized low-density lipoprotein-induced apoptotic dendritic cells as a novel therapy for atherosclerosis
    Vanessa Frodermann
    Division of Biopharmaceutics, Leiden Academic Centre for Drug Research, Leiden University, 2333 CC Leiden, The Netherlands
    J Immunol 194:2208-18. 2015
    ..These findings may translate into a safe treatment for patients with established cardiovascular diseases using patient-derived apop(ox)-DCs. ..
  28. doi request reprint RP105 deficiency attenuates early atherosclerosis via decreased monocyte influx in a CCR2 dependent manner
    Anouk Wezel
    Division of Biopharmaceutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Atherosclerosis 238:132-9. 2015
    ..We thus aimed to determine the role of RP105 in atherosclerotic lesion development using RP105 deficient mice on an atherosclerotic background...
  29. pmc Agonistic anti-TIGIT treatment inhibits T cell responses in LDLr deficient mice without affecting atherosclerotic lesion development
    Amanda C Foks
    Division of Biopharmaceutics, Leiden University, Leiden, The Netherlands
    PLoS ONE 8:e83134. 2013
    ..In the present study, we used an agonistic anti-TIGIT antibody to determine the effect of excessive TIGIT-signaling on atherosclerosis...
  30. doi request reprint Vascular neuropeptide Y contributes to atherosclerotic plaque progression and perivascular mast cell activation
    H Maxime Lagraauw
    Division of Biopharmaceutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands Electronic address
    Atherosclerosis 235:196-203. 2014
    ..In this study we thus aimed to determine whether NPY is expressed in atherosclerotic plaques and to establish its role in atherosclerotic plaque development...
  31. pmc TLR accessory molecule RP105 (CD180) is involved in post-interventional vascular remodeling and soluble RP105 modulates neointima formation
    Jacco C Karper
    Department of Surgery, LUMC, Leiden, The Netherlands
    PLoS ONE 8:e67923. 2013
    ..The role of RP105 in vascular remodeling, in particular post-interventional remodeling is unknown...
  32. pmc Growth differentiation factor 15 deficiency protects against atherosclerosis by attenuating CCR2-mediated macrophage chemotaxis
    Saskia C A de Jager
    Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Leiden University, Leiden, Netherlands
    J Exp Med 208:217-25. 2011
    ..Our study is the first to identify GDF-15 as an acute phase modifier of CCR2/TGFβRII-dependent inflammatory responses to vascular injury...
  33. doi request reprint Deletion of the high-density lipoprotein receptor scavenger receptor BI in mice modulates thrombosis susceptibility and indirectly affects platelet function by elevation of plasma free cholesterol
    Suzanne J A Korporaal
    Leiden Amsterdam Center for Drug Research, Division of Biopharmaceutics, Gorlaeus Laboratories, Einsteinweg 55, 2333 CC, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 31:34-42. 2011
    ..In mice, SR-BI deficiency results in increased plasma HDL cholesterol levels and enhanced susceptibility to atherosclerosis. The aim of this study was to investigate the role of SR-BI deficiency on platelet function...
  34. pmc Deficiency of the TLR4 analogue RP105 aggravates vein graft disease by inducing a pro-inflammatory response
    Anouk Wezel
    Division of Biopharmaceutics, LACDR, Leiden University, Leiden, The Netherlands
    Sci Rep 6:24248. 2016
    ..In vitro, RP105(-/-) smooth muscle cells and mast cells secreted higher levels of CCL2. In conclusion, aggravated vein graft disease caused by RP105 deficiency results from an increased local inflammatory response. ..
  35. doi request reprint Mast cells mediate neutrophil recruitment during atherosclerotic plaque progression
    Anouk Wezel
    Division of Biopharmaceutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Atherosclerosis 241:289-96. 2015
    ..As mast cells have been described to release a number of chemokines that mediate leukocyte fluxes, we propose that activated mast cells may play a pivotal role in leukocyte recruitment during atherosclerotic plaque progression...
  36. pmc Complement factor C5a induces atherosclerotic plaque disruptions
    Anouk Wezel
    Division of Biopharmaceutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    J Cell Mol Med 18:2020-30. 2014
    ..Therefore, intervention in complement factor C5a signalling may be a promising target in the prevention of acute atherosclerotic complications. ..
  37. ncbi request reprint Interruption of the Tnfrsf4/Tnfsf4 (OX40/OX40L) pathway attenuates atherogenesis in low-density lipoprotein receptor-deficient mice
    Eva J A van Wanrooij
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, P O Box 9502, 2300 RA Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 27:204-10. 2007
    ..In this study we assessed the role of the OX40/OX40L pathway in atherosclerosis and the effect of interruption of the OX40/OX40L pathway on lesion development...
  38. ncbi request reprint P-selectin as a candidate target in atherosclerosis
    Tom J M Molenaar
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Leiden University, P O Box 9502, 2300 RA Leiden, The Netherlands
    Biochem Pharmacol 66:859-66. 2003
    ..P-selectin ligands, like the lead structure we have developed here, can therefore be considered as promising tools to identify, target or antagonize P-selectin function within the chronically inflamed arterial wall...
  39. ncbi request reprint Repopulation of apolipoprotein E knockout mice with CCR2-deficient bone marrow progenitor cells does not inhibit ongoing atherosclerotic lesion development
    Jian Guo
    Division of Biopharmaceutics, Gorlaeus Laboratories, Leiden University, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 25:1014-9. 2005
    ..However, no data on CCR2 in the cause of established atherosclerosis have been reported so far...
  40. pmc Mast cell depletion in the preclinical phase of collagen-induced arthritis reduces clinical outcome by lowering the inflammatory cytokine profile
    Daniel van der Velden
    Division of Biopharmaceutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands
    Arthritis Res Ther 18:138. 2016
    ..Infiltrating mast cells can be found within the inflamed synovial tissue, however their role in disease pathogenesis is unclear. Therefore we have studied the role of mast cells during different phases of experimental arthritis...
  41. doi request reprint Targeted pH-dependent fluorescent activity-based cathepsin probes
    Sascha Hoogendoorn
    Leiden Institute of Chemistry, Leiden University, P O Box 9052, 2300 RA Leiden, The Netherlands
    Chem Commun (Camb) 47:9363-5. 2011
    ..Mannose receptor-dependent uptake of the probes in dendritic cells, followed by trafficking to acidic cellular compartments resulted in fluorescence as seen by live-cell imaging, and subsequent cathepsin inhibition...
  42. ncbi request reprint Microarray analysis indicates an important role for FABP5 and putative novel FABPs on a Western-type diet
    Menno Hoekstra
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, 2300 RA Leiden, The Netherlands
    J Lipid Res 47:2198-207. 2006
    ....
  43. doi request reprint Impaired effector memory T-cell regulation facilitates graft versus host disease in CCR7-deficient bone marrow transplant chimeras
    Saskia C A de Jager
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands
    Transplantation 88:631-9. 2009
    ..Here, we examined the effects of hematopoietic CC-chemokine receptor (CCR)7 deficiency on the development of GvHD...
  44. doi request reprint Abca1 deficiency protects the heart against myocardial infarction-induced injury
    Mieke C Louwe
    Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Atherosclerosis 251:159-63. 2016
    ..We explored the role of ATP-binding cassette transporter A1 (Abca1), in post-myocardial infarction (MI) cardiac injury...
  45. pmc Inhibition of lysophosphatidic acid receptors 1 and 3 attenuates atherosclerosis development in LDL-receptor deficient mice
    Eva Kritikou
    Division of Biopharmaceutics, LACDR, Leiden University, The Netherlands
    Sci Rep 6:37585. 2016
    ..Therefore, pharmacological inhibition of LPA1/3 receptors may prove a promising approach to diminish atherosclerosis development...
  46. pmc Mesenchymal Stem Cells Reduce Murine Atherosclerosis Development
    Vanessa Frodermann
    Division of Biopharmaceutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands
    Sci Rep 5:15559. 2015
    ..We show here for the first time that MSC treatment affects not only inflammatory responses but also significantly reduces dyslipidaemia in mice. This makes MSCs a potent candidate for atherosclerosis therapies. ..
  47. doi request reprint Inhibition of MicroRNA-494 Reduces Carotid Artery Atherosclerotic Lesion Development and Increases Plaque Stability
    Anouk Wezel
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands Division of Biopharmaceutics, LACDR, Leiden University, Leiden, The Netherlands Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands Idera Pharmaceuticals, Cambridge, MA
    Ann Surg 262:841-7; discussion 847-8. 2015
    ..We aimed to identify microRNAs that exert a broad effect on atherosclerotic plaque formation and stability in the carotid artery...
  48. doi request reprint Complement factor C5a as mast cell activator mediates vascular remodelling in vein graft disease
    Margreet R De Vries
    Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands
    Cardiovasc Res 97:311-20. 2013
    ..We hypothesize that C5a-mediated mast cell activation is involved in the development and destabilization of vein graft lesions...
  49. doi request reprint The peripheral blood mononuclear cell microRNA signature of coronary artery disease
    Menno Hoekstra
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Einsteinweg 55, P O Box 9502, 2300RA Leiden, The Netherlands
    Biochem Biophys Res Commun 394:792-7. 2010
    ..MicroRNAs are being used in the oncology field to characterize tumors and predict the survival of cancer patients. Here, we explored the potential of microRNAs as biomarkers for coronary artery disease (CAD) and acute coronary syndromes...
  50. ncbi request reprint HDL cholesterol levels are an important factor for determining the lifespan of erythrocytes
    Illiana Meurs
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden, The Netherlands
    Exp Hematol 33:1309-19. 2005
    ..The objective of the current study was to delineate the mechanism underlying development of anemia in the absence of SR-BI...
  51. ncbi request reprint Serine protease inhibitor Serp-1 strongly impairs atherosclerotic lesion formation and induces a stable plaque phenotype in ApoE-/-mice
    Ilze Bot
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Leiden, The Netherlands
    Circ Res 93:464-71. 2003
    ..Equally relevant, it enhances cellularity of the plaque core potentially leading to improved plaque stability. The above results indicate that Serp-1 constitutes a promising lead in antiatherosclerotic therapy...
  52. ncbi request reprint Scavenger receptors: friend or foe in atherosclerosis?
    Theo J C Van Berkel
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, University of Leiden, Gorlaeus Laboratories, Leiden, The Netherlands
    Curr Opin Lipidol 16:525-35. 2005
    ..This review focuses on the role of scavenger receptors in the development of atherosclerotic lesions...
  53. ncbi request reprint The effect of TGF-beta receptor binding peptides on smooth muscle cells
    Ingrid N Michon
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Leiden University, P O Box 9502, 2300 RA Leiden, The Netherlands
    Biochem Biophys Res Commun 293:1279-86. 2002
    ..In conclusion, IM-1 activity on VSMC is agonistic with TGF-beta, except for ECM synthesis, whereas the IM-2 peptide is antagonistic for some examined TGF-beta functions...
  54. ncbi request reprint Interleukins in atherosclerosis: molecular pathways and therapeutic potential
    Jan H von der Thüsen
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Leiden, The Netherlands
    Pharmacol Rev 55:133-66. 2003
    ..This may prove to be the real challenge for the development of interleukin-based anti-atherosclerotic therapies, once the mediators and their targets have been delineated...
  55. pmc CXCR4 blockade induces atherosclerosis by affecting neutrophil function
    Ilze Bot
    Division of Biopharmaceutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands Electronic address
    J Mol Cell Cardiol 74:44-52. 2014
    ..We here sought to investigate its impact on clinically relevant stages of atherosclerosis in mouse and man...
  56. ncbi request reprint Vaccination against VEGFR2 attenuates initiation and progression of atherosclerosis
    Arnaud D Hauer
    Division of Biopharmaceutics, Leiden University, The Netherlands
    Arterioscler Thromb Vasc Biol 27:2050-7. 2007
    ..Vascular endothelial growth factor receptor 2 (VEGFR2)-overexpressing cells may form an interesting target for the treatment of atherosclerosis because of their involvement in processes that contribute to this disease, such as angiogenesis...
  57. ncbi request reprint Targeting of peptides to restenotic vascular smooth muscle cells using phage display in vitro and in vivo
    Ingrid N Michon
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Leiden University, P O Box 9502, 2300 RA Leiden, The Netherlands
    Biochim Biophys Acta 1591:87-97. 2002
    ..The specific binding capacities of 5G6 and 5E5 phages suggest that these peptide sequences can be used for targeting of restenotic lesions, in which proliferating VSMC are the dominant cell type...
  58. doi request reprint A vaccine against atherosclerosis: myth or reality?
    Gijs Hm van Puijvelde
    Leiden University, LACDR, Division of Biopharmaceutics, Einsteinweg 55, 2300 RA Leiden, The Netherlands
    Future Cardiol 4:125-33. 2008
    ..In the near future, we expect an increased interest in vaccination against atherosclerosis and, maybe, the myth may become reality when the first clinical trials are performed...
  59. doi request reprint Acute and chronic psychological stress as risk factors for cardiovascular disease: Insights gained from epidemiological, clinical and experimental studies
    H Maxime Lagraauw
    Division of Biopharmaceutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands
    Brain Behav Immun 50:18-30. 2015
    ..Here we provide a concise overview of human and experimental animal data linking chronic and acute stress to CVD risk and increased progression of the underlying disease atherosclerosis. ..
  60. ncbi request reprint Anti-apoptotic serpins as therapeutics in cardiovascular diseases
    Johan Kuiper
    Division of Biopharmaceutics, Leiden Academic Centre for Drug Research, Leiden University, Gorlaeus Laboratories, Einsteinweg 55, 2333 CC Leiden, The Netherlands
    Cardiovasc Hematol Disord Drug Targets 13:111-22. 2013
    ..In this review, we will discuss the current knowledge on the role of serpins in cardiovascular diseases with particular emphasis on apoptotic cell death and the potential therapeutic applications. ..
  61. ncbi request reprint Uptake and processing of modified bacteriophage M13 in mice: implications for phage display
    Tom J M Molenaar
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Leiden University, Sylvius Laboratory, 2300 RA Leiden, The Netherlands
    Virology 293:182-91. 2002
    ....
  62. ncbi request reprint Specific inhibition of P-selectin-mediated cell adhesion by phage display-derived peptide antagonists
    Tom J M Molenaar
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Leiden University, The Netherlands
    Blood 100:3570-7. 2002
    ....
  63. doi request reprint The impact of mast cells on cardiovascular diseases
    Eva Kritikou
    Division of Biopharmaceutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands
    Eur J Pharmacol 778:103-15. 2016
    ..The acquired evidence renders mast cells and their mediators as potential prognostic markers and therapeutic targets in a broad spectrum of pathophysiological conditions related to cardiovascular diseases. ..
  64. doi request reprint Orchestrating immune responses: How size, shape and rigidity affect the immunogenicity of particulate vaccines
    Naomi Benne
    Division of Drug Delivery Technology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands Cluster BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands
    J Control Release 234:124-34. 2016
    ..Herein, we systematically review the role of the size, shape and rigidity of particulate vaccines in enhancing and skewing T cell response and attempted to provide a "roadmap" for rational vaccine design. ..
  65. pmc Treating atherosclerosis with regulatory T cells
    Amanda C Foks
    From the Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA A C F, A H L and Division of Biopharmaceutics, Leiden Academic Centre for Drug Research, Leiden University, Gorlaeus Laboratories, Leiden, The Netherlands J K
    Arterioscler Thromb Vasc Biol 35:280-7. 2015
    ..In this review, we focus on the recent knowledge on Treg subsets, their activity and function in atherosclerosis, and discuss promising strategies to use Tregs as a therapeutic tool to prevent cardiovascular disease. ..
  66. doi request reprint Receptor-mediated targeting of cathepsins in professional antigen presenting cells
    Ulrik Hillaert
    Leiden Institute of Chemistry, Leiden University, P O Box 9052, 2300 RA Leiden, The Netherlands
    Angew Chem Int Ed Engl 48:1629-32. 2009
    ..Uptake of the probe in professional antigen presenting cells and subsequent labeling of cathepsins proceeded in a mannose-receptor dependent manner...
  67. ncbi request reprint HIV entry inhibitor TAK-779 attenuates atherogenesis in low-density lipoprotein receptor-deficient mice
    Eva J A van Wanrooij
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 25:2642-7. 2005
    ..TAK-779 is an antagonist for the chemokine receptors CCR5 and CXCR3, which are expressed on leukocytes, especially T-helper 1 cells, and these receptors may be involved in recruitment of these cells to atherosclerotic plaques...
  68. pmc Receptors, mediators, and mechanisms involved in bacterial sepsis and septic shock
    Edwin S Van Amersfoort
    Division of Biopharmaceutics, Leiden Amsterdam Center of Drug Research, Leiden University, Leiden, The Netherlands
    Clin Microbiol Rev 16:379-414. 2003
    ..Finally, the therapies for the treatment of bacterial sepsis and septic shock are discussed in relation to the action of the aforementioned receptors and proteins...
  69. ncbi request reprint KLF2 suppresses TGF-beta signaling in endothelium through induction of Smad7 and inhibition of AP-1
    Reinier A Boon
    Department of Medical Biochemistry, Academic Medical Center, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 27:532-9. 2007
    ..Here, we describe its detailed effects on transforming growth factor-beta (TGF-beta) signaling, which normally has proatherogenic effects on endothelium...
  70. ncbi request reprint Prolonged shear stress and KLF2 suppress constitutive proinflammatory transcription through inhibition of ATF2
    Joost O Fledderus
    Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Blood 109:4249-57. 2007
    ....
  71. ncbi request reprint Hyperglycemia accelerates arterial thrombus formation and attenuates the antithrombotic response to endotoxin in mice
    Hjalmar R Hansen
    Laboratory for Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Blood Coagul Fibrinolysis 18:627-36. 2007
    ..This reduced rate of thrombus formation was attenuated by hyperglycemia. Together, these data establish a discrete but clear contribution of hyperglycemia in experimental arterial thrombosis...
  72. pmc Distinctive expression of chemokines and transforming growth factor-beta signaling in human arterial endothelium during atherosclerosis
    Oscar L Volger
    Department of Medical Biochemistry, Room K1 114, Academic Medical Center, University of Amsterdam, Meibergdreef 15, NL 1105 AZ, Amsterdam, The Netherlands
    Am J Pathol 171:326-37. 2007
    ..Thus, we identified truly common, local molecular denominators of pathological changes to vascular endothelium, with a marked distinction of endothelial phenotype between early and advanced plaques...