S W Kok
Affiliation: Leiden University Medical Center
Country: The Netherlands
- Reduction of plasma leptin levels and loss of its circadian rhythmicity in hypocretin (orexin)-deficient narcoleptic humansS W Kok
Department of General Internal Medicine, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
J Clin Endocrinol Metab 87:805-9. 2002..As leptin deficiency clearly leads to morbid obesity in experimental animals and humans, we infer that the observed reduction of plasma leptin levels may predispose narcoleptic humans to weight gain...
- Dynamics of the pituitary-adrenal ensemble in hypocretin-deficient narcoleptic humans: blunted basal adrenocorticotropin release and evidence for normal time-keeping by the master pacemakerS W Kok
Department of General Internal Medicine C1 R38, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
J Clin Endocrinol Metab 87:5085-91. 2002..The reduced (basal) ACTH secretion and the diminished secretory process regularity of the ACTH/cortisol ensemble conjointly suggest that hypocretin deficiency induces changes in the interplay between PA hormones...
- Pulsatile LH release is diminished, whereas FSH secretion is normal, in hypocretin-deficient narcoleptic menS W Kok
Leiden University Medical Center, Department of General Internal Medicine, 2300 RC, The Netherlands
Am J Physiol Endocrinol Metab 287:E630-6. 2004..In particular, reduced LH release in the face of normal pituitary responsivity to GnRH stimulation in narcoleptic men suggests that hypocretins promote endogenous GnRH secretion...
- Clinical outcome after standardized versus dosimetric radioiodine treatment of hyperthyroidism: an equivalence studyS W Kok
Department of General Internal Medicine, Leiden University Medical Centre, The Netherlands
Nucl Med Commun 21:1071-8. 2000....