Frederikus A Klok

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. doi A simple non-invasive diagnostic algorithm for ruling out chronic thromboembolic pulmonary hypertension in patients after acute pulmonary embolism
    F A Klok
    Section of Vascular Medicine, Department of General Internal Medicine Endocrinology, LUMC, Leiden, The Netherlands
    Thromb Res 128:21-6. 2011
  2. doi Chronic pulmonary embolism and pulmonary hypertension
    Frederikus A Klok
    Department of Thrombosis and Haemostasis, Leiden University Medical Center, Albinusdreef 2, Leiden, The Netherlands
    Semin Respir Crit Care Med 33:199-204. 2012
  3. ncbi [Acute pulmonary embolism: beware of the wolf in sheep's clothing]
    Frederikus A Klok
    Ziekenhuis Bronovo, afd Cardiologie Den Haag, The Netherlands
    Ned Tijdschr Geneeskd 156:A3675. 2012
  4. doi Recovery of right and left ventricular function after acute pulmonary embolism
    F A Klok
    Section of Vascular Medicine, Department of General Internal Medicine Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
    Clin Radiol 66:1203-7. 2011
  5. pmc Pulmonary flow profile and distensibility following acute pulmonary embolism
    Frederikus A Klok
    Section of Vascular Medicine, Department of General Internal Medicine Endocrinology, LUMC, Leiden, The Netherlands
    J Cardiovasc Magn Reson 13:14. 2011
  6. ncbi Epidemiology and management of chronic thromboembolic pulmonary hypertension
    F A Klok
    Department of General Internal Medicine Endocrinology, Section of Vascular Medicine, University Medical Center, Leiden, The Netherlands
    Neth J Med 68:347-51. 2010
  7. doi Prevalence and potential determinants of exertional dyspnea after acute pulmonary embolism
    F A Klok
    Department of General Internal Medicine Endocrinology, LUMC, Leiden, The Netherlands
    Respir Med 104:1744-9. 2010
  8. doi Quality of life in long-term survivors of acute pulmonary embolism
    Frederikus A Klok
    Leiden University Medical Center C4 70, Leiden, The Netherlands
    Chest 138:1432-40. 2010
  9. pmc Prospective cardiopulmonary screening program to detect chronic thromboembolic pulmonary hypertension in patients after acute pulmonary embolism
    Frederikus A Klok
    Section of Vascular Medicine, Department of General Internal Medicine Endocrinology, LUMC, Leiden, The Netherlands
    Haematologica 95:970-5. 2010
  10. doi Quality of life after pulmonary embolism: validation of the PEmb-QoL Questionnaire
    F A Klok
    Section of Vascular Medicine, Department of General Internal Medicine Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 8:523-32. 2010

Collaborators

Detail Information

Publications55

  1. doi A simple non-invasive diagnostic algorithm for ruling out chronic thromboembolic pulmonary hypertension in patients after acute pulmonary embolism
    F A Klok
    Section of Vascular Medicine, Department of General Internal Medicine Endocrinology, LUMC, Leiden, The Netherlands
    Thromb Res 128:21-6. 2011
    ..Our aim was to construct a diagnostic model for ruling out chronic thromboembolic pulmonary hypertension (CTEPH) in symptomatic patients after acute pulmonary embolism (PE) that is based on simple, non-invasive tests...
  2. doi Chronic pulmonary embolism and pulmonary hypertension
    Frederikus A Klok
    Department of Thrombosis and Haemostasis, Leiden University Medical Center, Albinusdreef 2, Leiden, The Netherlands
    Semin Respir Crit Care Med 33:199-204. 2012
    ..Pulmonary thromboendarterectomy is the treatment of choice. In certain patients with persistent or recurrent pulmonary hypertension after surgery or with inoperable disease, pharmacotherapy might be beneficial...
  3. ncbi [Acute pulmonary embolism: beware of the wolf in sheep's clothing]
    Frederikus A Klok
    Ziekenhuis Bronovo, afd Cardiologie Den Haag, The Netherlands
    Ned Tijdschr Geneeskd 156:A3675. 2012
    ....
  4. doi Recovery of right and left ventricular function after acute pulmonary embolism
    F A Klok
    Section of Vascular Medicine, Department of General Internal Medicine Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
    Clin Radiol 66:1203-7. 2011
    ..To evaluate recovery of cardiac function after acute pulmonary embolism (PE)...
  5. pmc Pulmonary flow profile and distensibility following acute pulmonary embolism
    Frederikus A Klok
    Section of Vascular Medicine, Department of General Internal Medicine Endocrinology, LUMC, Leiden, The Netherlands
    J Cardiovasc Magn Reson 13:14. 2011
    ..Proof of concept study evaluating CMR as screening tool for chronic thromboembolic pulmonary hypertension (CTEPH) in patients treated for acute pulmonary embolism (PE)...
  6. ncbi Epidemiology and management of chronic thromboembolic pulmonary hypertension
    F A Klok
    Department of General Internal Medicine Endocrinology, Section of Vascular Medicine, University Medical Center, Leiden, The Netherlands
    Neth J Med 68:347-51. 2010
    ..The preferred treatment is pulmonary endarterectomy. In certain patients with inoperable disease or with persistent or recurrent pulmonary hypertension after surgery, pharmacotherapy might be beneficial...
  7. doi Prevalence and potential determinants of exertional dyspnea after acute pulmonary embolism
    F A Klok
    Department of General Internal Medicine Endocrinology, LUMC, Leiden, The Netherlands
    Respir Med 104:1744-9. 2010
    ..The exact prevalence and etiology of exertional dyspnea in the clinical course of acute pulmonary embolism (PE) have not yet been established...
  8. doi Quality of life in long-term survivors of acute pulmonary embolism
    Frederikus A Klok
    Leiden University Medical Center C4 70, Leiden, The Netherlands
    Chest 138:1432-40. 2010
    ....
  9. pmc Prospective cardiopulmonary screening program to detect chronic thromboembolic pulmonary hypertension in patients after acute pulmonary embolism
    Frederikus A Klok
    Section of Vascular Medicine, Department of General Internal Medicine Endocrinology, LUMC, Leiden, The Netherlands
    Haematologica 95:970-5. 2010
    ..We determined the incidence of chronic thromboembolic pulmonary hypertension after acute pulmonary embolism and the utility of a screening program for this disease...
  10. doi Quality of life after pulmonary embolism: validation of the PEmb-QoL Questionnaire
    F A Klok
    Section of Vascular Medicine, Department of General Internal Medicine Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 8:523-32. 2010
    ..Recently, the Pulmonary Embolism Quality of Life (PEmb-QoL) Questionnaire has been developed to address this gap...
  11. doi Patient outcomes after acute pulmonary embolism. A pooled survival analysis of different adverse events
    Frederikus A Klok
    Section of Vascular Medicine, Department of General Internal Medicine Endocrinology, LUMC, Leiden, The Netherlands
    Am J Respir Crit Care Med 181:501-6. 2010
    ..There is a lack of information on the long-term prognosis of patients with acute pulmonary embolism (PE)...
  12. doi Risk of arterial cardiovascular events in patients after pulmonary embolism
    Frederikus A Klok
    Section of Vascular Medicine, Department of General Internal Medicine Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
    Blood 114:1484-8. 2009
    ....
  13. doi Persistent dyspnea complaints at long-term follow-up after an episode of acute pulmonary embolism: results of a questionnaire
    F A Klok
    Section of Vascular Medicine, Department of General Internal Medicine Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Intern Med 19:625-9. 2008
    ..There is a lack of information on long term complications of patients with pulmonary embolism (PE), including chronic complaints of dyspnea...
  14. doi Simplification of the revised Geneva score for assessing clinical probability of pulmonary embolism
    Frederikus A Klok
    Section of Vascular Medicine, Department of General Internal Medicine Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
    Arch Intern Med 168:2131-6. 2008
    ..The variables of the decision rule have different weights, which could lead to miscalculations in an acute setting. We have validated a simplified version of the revised Geneva score...
  15. ncbi High D-dimer level is associated with increased 15-d and 3 months mortality through a more central localization of pulmonary emboli and serious comorbidity
    F A Klok
    Section of Vascular Medicine, Department of General Internal Medicine Endocrinology, Leiden University Medical Centre, Leiden, The Netherlands
    Br J Haematol 140:218-22. 2008
    ..Active malignancy, being an inpatient at time of diagnosis and age over 65 years were associated with higher D-dimer levels and worse 3-month survival...
  16. ncbi Comparison of the revised Geneva score with the Wells rule for assessing clinical probability of pulmonary embolism
    F A Klok
    Section of Vascular Medicine, Department of General Internal Medicine Endocrinology, LUMC, Leiden, The Netherlands
    J Thromb Haemost 6:40-4. 2008
    ..We have compared the performance of the revised Geneva score with the Wells rule, and their usefulness for ruling out PE in combination with D-dimer measurement...
  17. doi NT-pro-BNP levels in patients with acute pulmonary embolism are correlated to right but not left ventricular volume and function
    Sharif M Pasha
    Department of Thrombosis and Haemostasis, Leiden University Medical Centre, Leiden, The Netherlands
    Thromb Haemost 108:367-72. 2012
    ..These observations provide pathophysiological ground for the well-known prognostic value of NT-pro-BNP in acute PE...
  18. doi Measurement of right and left ventricular function by ECG-synchronized CT scanning in patients with acute pulmonary embolism: usefulness for predicting short-term outcome
    Noortje van der Bijl
    Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    Chest 140:1008-15. 2011
    ..We assessed the possible incremental value of ventricular function with ECG-synchronized cardiac CT scanning over pulmonary CT scan angiography (CTA) for predicting short-term outcome in patients with suspected acute PE...
  19. doi Optimization of the diagnostic management of clinically suspected pulmonary embolism in hospitalized patients
    Tom van der Hulle
    Department of Thrombosis and Haemostasis, LUMC, Leiden, The Netherlands
    Br J Haematol 167:681-6. 2014
    ....
  20. doi Diagnostic outcome management study in patients with clinically suspected recurrent acute pulmonary embolism with a structured algorithm
    Inge C M Mos
    Department of Thrombosis and Haemostasis, Leiden University Medical Center, Leiden, The Netherlands Electronic address
    Thromb Res 133:1039-44. 2014
    ....
  21. doi Imaging tests in the diagnosis of pulmonary embolism
    Inge C M Mos
    Department of Thrombosis and Haemostasis, Leiden University Medical Center, Albinusdreef 2, Leiden, The Netherlands
    Semin Respir Crit Care Med 33:138-43. 2012
    ..Furthermore the diagnostic process in patients with clinically suspected recurrent PE, PE during pregnancy, and PE in the elderly and in patients with malignancy are discussed...
  22. doi Risk profile and clinical outcome of symptomatic subsegmental acute pulmonary embolism
    Paul L den Exter
    Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands
    Blood 122:1144-9; quiz 1329. 2013
    ..8; 95% CI: 1.3-11.1). This study indicates that patients with SSPE mimic those with more proximally located PE in regards to their risk profile and clinical outcome. ..
  23. doi Computed tomography pulmonary angiography as a single imaging test to rule out pulmonary embolism
    Frederikus A Klok
    Section of Vascular Medicine, Department of General Internal Medicine Endocrinology, LUMC, Leiden, The Netherlands
    Curr Opin Pulm Med 17:380-6. 2011
    ....
  24. doi Evaluation of the new simple and objective clinical decision rule "I-DVT" in patients with clinically suspected acute deep vein thrombosis
    Charlotte E A Dronkers
    Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands Electronic address
    Thromb Res 141:112-8. 2016
    ..We evaluated the diagnostic performance of the I-DVT score, which consists of four easy assessable variables: Immobilization, >3cm Difference in calve circumferences, prior Venous thromboembolism (VTE) and active malignant Tumor...
  25. doi Cohort Study on the Management of Cancer-Associated Venous Thromboembolism Aimed at the Safety of Stopping Anticoagulant Therapy in Patients Cured of Cancer
    Tom van der Hulle
    Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands Electronic address
    Chest 149:1245-51. 2016
    ....
  26. doi Outpatient versus inpatient treatment in patients with pulmonary embolism: a meta-analysis
    Wendy Zondag
    Dept of Thrombosis and Haemostasis, LUMC, Leiden, The Netherlands
    Eur Respir J 42:134-44. 2013
    ..We conclude that home treatment or early discharge of selected low-risk patients with pulmonary embolism is as safe as inpatient treatment. ..
  27. doi How I diagnose acute pulmonary embolism
    Menno V Huisman
    Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands
    Blood 121:4443-8. 2013
    ..The aim of this review is to provide clinicians this practical diagnostic management approach using evidence from the literature...
  28. doi Residual venous thrombosis as predictive factor for recurrent venous thromboembolim in patients with proximal deep vein thrombosis: a sytematic review
    Melanie Tan
    Section of Vascular Medicine, Department of General Internal Medicine Endocrinology, LUMC, Albinusdreef 2, Leiden, The Netherlands
    Br J Haematol 153:168-78. 2011
    ..This systematic review shows a positive relationship between residual thrombosis and recurrent VTE during follow-up. Assessing residual thrombosis could be useful in individual recurrence risk estimation...
  29. doi Risk of atherothrombotic events in patients after proximal deep-vein thrombosis
    Sharif M Pasha
    Department of Thrombosis and Hemostasis, Leiden University Medical Centre, Leiden, The Netherlands
    Blood Coagul Fibrinolysis 27:13-8. 2016
    ..Interestingly, our results raise the question whether the known risk factors for ATE and venous thromboembolism attribute equally in pulmonary embolism and DVT patients, and contradict a causal relation between ATE and proximal DVT. ..
  30. pmc Association between micro particle-tissue factor activity, factor VIII activity and recurrent VTE in patients with acute pulmonary embolism
    Judith Kooiman
    Department of Thrombosis and Haemostasis, Leiden University Medical Center, C7 Q, P O Box 9600, 2300 RC, Leiden, The Netherlands
    J Thromb Thrombolysis 40:323-30. 2015
    ..Studies on the association between microparticle expressing tissue factor (MP-TF) activity, FVIII activity (..
  31. pmc Recurrence risk after anticoagulant treatment of limited duration for late, second venous thromboembolism
    Tom van der Hulle
    Department of Thrombosis and Hemostasis, Leiden University Medical Center, The Netherlands
    Haematologica 100:188-93. 2015
    ..Most patients may, therefore, be better served by treatment of indefinite duration, although the risk-benefit ratio of extended anticoagulation should be weighed for every patient. ..
  32. doi Impact of delay in clinical presentation on the diagnostic management and prognosis of patients with suspected pulmonary embolism
    Paul L den Exter
    Department of Thrombosis and Haemostasis, Leiden University Medical Center, Leiden, The Netherlands
    Am J Respir Crit Care Med 187:1369-73. 2013
    ..The nonspecific clinical presentation of pulmonary embolism (PE) frequently leads to delay in its diagnosis...
  33. doi D-dimer testing in patients with suspected pulmonary embolism and impaired renal function
    Reza Karami-Djurabi
    Section of Vascular Medicine, Department of General Internal Medicine Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Med 122:1050-3. 2009
    ..We evaluated the utility of D-dimer testing in patients with impaired renal function...
  34. doi Reliability of diagnosing incidental pulmonary embolism in cancer patients
    Paul L den Exter
    Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands Electronic address
    Thromb Res 136:531-4. 2015
    ..Although this generally leads to therapeutic interventions, the accuracy of diagnosing PE on routinely performed contrast enhanced CT scans is unknown...
  35. pmc The HAS-BLED Score Identifies Patients with Acute Venous Thromboembolism at High Risk of Major Bleeding Complications during the First Six Months of Anticoagulant Treatment
    Judith Kooiman
    Department of Thrombosis and Haemostasis, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 10:e0122520. 2015
    ..We analyzed whether the HAS-BLED score accurately identifies patients at high risk of major bleeds during VKA treatment for acute VTE...
  36. doi Performance of a diagnostic algorithm based on a prediction rule, D-dimer and CT-scan for pulmonary embolism in patients with previous venous thromboembolism. A systematic review and meta-analysis
    María José Fabiá Valls
    Tom van der Hulle, MD, Department of Thrombosis and Hemostasis, Leiden University Medical Center, Albinusdreef 2, P O Box 9600, 2300 RC, Leiden, The Netherlands, Tel 31 71 526 8132, Fax 31 71 526 6868, E mail
    Thromb Haemost 113:406-13. 2015
    ....
  37. doi Diagnosis of pulmonary embolism: Advances and pitfalls
    Paul L den Exter
    Department of Thrombosis and Haemostasis, Leiden University Medical Center, Leiden, The Netherlands
    Best Pract Res Clin Haematol 25:295-302. 2012
    ..This review will focus on recent advances and pitfalls that remain in the diagnostic work-up of patients with suspected acute PE...
  38. doi Brain-type natriuretic peptide levels in the prediction of adverse outcome in patients with pulmonary embolism: a systematic review and meta-analysis
    Frederikus A Klok
    Department of General Internal Medicine, Section of Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Am J Respir Crit Care Med 178:425-30. 2008
    ..The potential role of elevated brain-type natriuretic peptides (BNP) in the differentiation of patients suffering from acute pulmonary embolism at risk for adverse clinical outcome has not been fully established...
  39. ncbi [Exclusion of deep-vein thrombosis and pulmonary embolism using clinical decision rules and D-dimer tests]
    Inge C M Mos
    Leids Universitair Medisch Centrum, afd Algemene Interne Geneeskunde Endocrinologie, Leiden, The Netherlands
    Ned Tijdschr Geneeskd 154:A2054. 2010
    ..The diagnostic value of the D-dimer test during suspected recurrence of a VTE is yet to be determined...
  40. doi Diagnostic management of clinically suspected acute pulmonary embolism
    M V Huisman
    Section of Vascular Medicine, Department of General Internal Medicine Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 7:312-7. 2009
    ....
  41. doi Magnetic resonance direct thrombus imaging differentiates acute recurrent ipsilateral deep vein thrombosis from residual thrombosis
    Melanie Tan
    Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands
    Blood 124:623-7. 2014
    ..98). MRDTI images were adequate for interpretation in 95% of the cases. MRDTI is a sensitive and reproducible method for distinguishing acute ipsilateral recurrent DVT from 6-month-old chronic residual thrombi in the leg veins. ..
  42. doi The newer anticoagulants in thrombosis control in cancer patients
    Paul L den Exter
    Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands Electronic address
    Semin Oncol 41:339-45. 2014
    ..The potential of these agents in the setting of cancer-associated VTE will be discussed and directions for future research will be provided. ..
  43. doi Safety of ruling out acute pulmonary embolism by normal computed tomography pulmonary angiography in patients with an indication for computed tomography: systematic review and meta-analysis
    I C M Mos
    Section of Vascular Medicine, Department of General Internal Medicine Endocrinology, Leiden, The Netherlands
    J Thromb Haemost 7:1491-8. 2009
    ....
  44. doi Safety of excluding acute pulmonary embolism based on an unlikely clinical probability by the Wells rule and normal D-dimer concentration: a meta-analysis
    S M Pasha
    Section of Vascular Medicine, Department of General Internal Medicine Endocrinology, LUMC, Leiden, The Netherlands
    Thromb Res 125:e123-7. 2010
    ..We performed a meta-analysis to determine the negative predictive value (NPV) of an "unlikely" CDR (<or=4 points) combined with a normal D-dimer test and the safety of withholding anti-coagulants based on these criteria...
  45. ncbi Efficacy and Safety of Outpatient Treatment Based on the Hestia Clinical Decision Rule with or without N-Terminal Pro-Brain Natriuretic Peptide Testing in Patients with Acute Pulmonary Embolism. A Randomized Clinical Trial
    Paul L den Exter
    1 Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands
    Am J Respir Crit Care Med 194:998-1006. 2016
    ..Outpatient treatment of pulmonary embolism (PE) may lead to improved patient satisfaction and reduced healthcare costs. However, trials to assess its safety and the optimal method for patient selection are scarce...
  46. doi Advances in the diagnosis and management of acute pulmonary embolism
    Paul L den Exter
    Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands Electronic address
    Thromb Res 133:S10-6. 2014
    ..This article reviews recent advances and challenges that remain in the diagnostic work-up and initial management of acute, clinically stable PE...
  47. doi Comparison of the clinical usefulness of two quantitative D-Dimer tests in patients with a low clinical probability of pulmonary embolism
    R Karami Djurabi
    Section of Vascular Medicine, Department of General Internal Medicine Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
    Thromb Res 123:771-4. 2009
    ..The diagnostic performance and the clinical efficiency different D-Dimer assays in the exclusion of pulmonary embolism (PE) have not yet been compared in a clinical outcome study...
  48. pmc Accurate diagnosis of iliac vein thrombosis in pregnancy with magnetic resonance direct thrombus imaging (MRDTI)
    Charlotte E A Dronkers
    Department of Thrombosis and Hemostasis, Leids Universitair Medisch Centrum, Leiden, The Netherlands
    BMJ Case Rep 2016:. 2016
    ..Treatment with anticoagulants was started. 6 months after the diagnosis, the patient is doing well and does not report signs of post-thrombotic syndrome...
  49. doi To screen or not to screen for chronic thromboembolic pulmonary hypertension after acute pulmonary embolism
    Yvonne M Ende-Verhaar
    Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands Electronic address
    Thromb Res 151:1-7. 2017
    ..In this review, we discuss current knowledge of available screening instruments for CTEPH, provide recommendations for clinical practice and expand on future developments of this particular subject...
  50. doi Current challenges in diagnostic imaging of venous thromboembolism
    Menno V Huisman
    Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands
    Blood 126:2376-82. 2015
    ..In this review, we present 3 evidence-based patient cases to underline recent developments in the imaging diagnosis of venous thromboembolism. ..
  51. doi Current challenges in diagnostic imaging of venous thromboembolism
    Menno V Huisman
    Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands
    Hematology Am Soc Hematol Educ Program 2015:202-9. 2015
    ..In this review, we present 3 evidence-based patient cases to underline recent developments in the imaging diagnosis of venous thromboembolism. ..
  52. doi Update on techniques for the diagnosis of pulmonary embolism
    Inge Cm Mos
    Leiden University Medical Centre, Section of Vascular Medicine, Department of General Internal Medicine Endocrinology, Albinusdreef 2, Postbus 9600, 2300 RC Leiden, the Netherlands 003171 5262085 003171 5248140
    Expert Opin Med Diagn 5:49-61. 2011
    ..The high incidence in addition to the potential harm from false-positive or false-negative diagnostic decisions underline the importance of a standardised diagnostic algorithm with high sensitivity as well as specificity...
  53. ncbi [Reliability of clinical decision rules in diagnosing acute pulmonary embolism]
    Inge C M Mos
    Leids Universitair Medisch Centrum, afd Trombose en Hemostas, Leiden, The Netherlands
    Ned Tijdschr Geneeskd 156:A4216. 2012
    ....
  54. doi Elevated D-dimer levels predict recurrence in patients with idiopathic venous thromboembolism: a meta-analysis
    E Bruinstroop
    Leiden University Medical Center, Section of Vascular Medicine, Department of General Internal Medicine Endocrinology, Leiden, The Netherlands
    J Thromb Haemost 7:611-8. 2009
    ..The evidence on the optimal duration of treatment in patients with an idiopathic venous thromboembolic event (VTE) is inconclusive. d-dimer testing to predict recurrent VTE has been evaluated in several studies...
  55. ncbi Alternative diagnosis other than pulmonary embolism as a subjective variable in the Wells clinical decision rule: not so bad after all
    F A Klok
    J Thromb Haemost 5:1079-80. 2007