Hermien E Kan

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. doi request reprint Differences in apparent diffusion coefficients of brain metabolites between grey and white matter in the human brain measured at 7 T
    Hermien E Kan
    CJ Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    Magn Reson Med 67:1203-9. 2012
  2. doi request reprint Gated dynamic 31P MRS shows reduced contractile phosphocreatine breakdown in mice deficient in cytosolic creatine kinase and adenylate kinase
    Hermien E Kan
    Department of Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    NMR Biomed 22:523-31. 2009
  3. doi request reprint Quantitative MR imaging of individual muscle involvement in facioscapulohumeral muscular dystrophy
    Hermien E Kan
    Department of Radiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Neuromuscul Disord 19:357-62. 2009
  4. pmc In vivo 31P MRS detection of an alkaline inorganic phosphate pool with short T1 in human resting skeletal muscle
    H E Kan
    C J Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    NMR Biomed 23:995-1000. 2010
  5. doi request reprint Only fat infiltrated muscles in resting lower leg of FSHD patients show disturbed energy metabolism
    H E Kan
    Department of Radiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    NMR Biomed 23:563-8. 2010
  6. ncbi request reprint In vivo magnetic resonance spectroscopy of transgenic mouse models with altered high-energy phosphoryl transfer metabolism
    W Klaas Jan Renema
    Department of Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    NMR Biomed 20:448-67. 2007
  7. ncbi request reprint In vivo magnetic resonance spectroscopy of transgenic mice with altered expression of guanidinoacetate methyltransferase and creatine kinase isoenzymes
    Arend Heerschap
    Department of Radiology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    Subcell Biochem 46:119-48. 2007
  8. ncbi request reprint Creatine uptake in brain and skeletal muscle of mice lacking guanidinoacetate methyltransferase assessed by magnetic resonance spectroscopy
    Hermien E Kan
    Department of Radiology, Radboud University Nijmegen Medical Center, Geert Grooteplein 10, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    J Appl Physiol (1985) 102:2121-7. 2007
  9. doi request reprint Longitudinal metabolite changes in Huntington's disease during disease onset
    Simon J A van den Bogaard
    Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    J Huntingtons Dis 3:377-86. 2014
  10. doi request reprint Improved signal to noise in proton spectroscopy of the human calf muscle at 7 T using localized B1 calibration
    Maarten J Versluis
    Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    Magn Reson Med 63:207-11. 2010

Collaborators

Detail Information

Publications23

  1. doi request reprint Differences in apparent diffusion coefficients of brain metabolites between grey and white matter in the human brain measured at 7 T
    Hermien E Kan
    CJ Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    Magn Reson Med 67:1203-9. 2012
    ..These differences can probably be attributed to different compartmentalization as well as to the differential impact of diffusion time on ADC of different molecules under conditions of restricted diffusion...
  2. doi request reprint Gated dynamic 31P MRS shows reduced contractile phosphocreatine breakdown in mice deficient in cytosolic creatine kinase and adenylate kinase
    Hermien E Kan
    Department of Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    NMR Biomed 22:523-31. 2009
    ....
  3. doi request reprint Quantitative MR imaging of individual muscle involvement in facioscapulohumeral muscular dystrophy
    Hermien E Kan
    Department of Radiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Neuromuscul Disord 19:357-62. 2009
    ..Typically, muscle involvement was non-uniform even within one muscle, indicating that MRI can be used as a valuable tool to study pathophysiology and therapy evaluation in FSHD...
  4. pmc In vivo 31P MRS detection of an alkaline inorganic phosphate pool with short T1 in human resting skeletal muscle
    H E Kan
    C J Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    NMR Biomed 23:995-1000. 2010
    ..3 ± 0.4 s vs 1.4 ± 0.5 s for Pi(1) and Pi(2), respectively. Together, these results suggest that the intra-mitochondrial Pi pool in resting human skeletal muscle may be visible with 31P MRS at high field...
  5. doi request reprint Only fat infiltrated muscles in resting lower leg of FSHD patients show disturbed energy metabolism
    H E Kan
    Department of Radiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    NMR Biomed 23:563-8. 2010
    ..Normal appearing muscles on T1 weighted images of patients showed normal phosphoryl metabolism, which suggests that in FSHD disease progression is truly muscle specific...
  6. ncbi request reprint In vivo magnetic resonance spectroscopy of transgenic mouse models with altered high-energy phosphoryl transfer metabolism
    W Klaas Jan Renema
    Department of Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    NMR Biomed 20:448-67. 2007
    ....
  7. ncbi request reprint In vivo magnetic resonance spectroscopy of transgenic mice with altered expression of guanidinoacetate methyltransferase and creatine kinase isoenzymes
    Arend Heerschap
    Department of Radiology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    Subcell Biochem 46:119-48. 2007
    ....
  8. ncbi request reprint Creatine uptake in brain and skeletal muscle of mice lacking guanidinoacetate methyltransferase assessed by magnetic resonance spectroscopy
    Hermien E Kan
    Department of Radiology, Radboud University Nijmegen Medical Center, Geert Grooteplein 10, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    J Appl Physiol (1985) 102:2121-7. 2007
    ..Our results can provide the basis for additional experiments to optimize Cr supplementation in GAMT deficiency, as increases in brain Cr are slow in patients after Cr supplementation...
  9. doi request reprint Longitudinal metabolite changes in Huntington's disease during disease onset
    Simon J A van den Bogaard
    Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    J Huntingtons Dis 3:377-86. 2014
    ..Previous cross-sectional magnetic resonance spectroscopy (MRS) studies in Huntington's disease (HD) have demonstrated differences in metabolite concentrations in several regions of interest, especially the putamen and caudate nucleus...
  10. doi request reprint Improved signal to noise in proton spectroscopy of the human calf muscle at 7 T using localized B1 calibration
    Maarten J Versluis
    Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    Magn Reson Med 63:207-11. 2010
    ..This new technique was able to measure the inhomogeneous radiofrequency field at 7 T and its use resulted in a considerable signal-to-noise ratio increase...
  11. pmc 31P MR spectroscopy and computational modeling identify a direct relation between Pi content of an alkaline compartment in resting muscle and phosphocreatine resynthesis kinetics in active muscle in humans
    Joep W M van Oorschot
    Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 8:e76628. 2013
    ..75). Taken together, these results suggest that the Pi2 resonance in resting human skeletal muscle observed at 7T provides a quantitative MR-based functional measure of mitochondrial density...
  12. pmc MRI and localized proton spectroscopy in human leg muscle at 7 Tesla using longitudinal traveling waves
    Andrew G Webb
    C J Gorter Center for High Field Magnetic Resonance Imaging, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    Magn Reson Med 63:297-302. 2010
    ..If a local receive coil is used in combination with the remote transmit coil, then the signal-to-noise improves significantly, as expected...
  13. doi request reprint Decreased cerebral perfusion in Duchenne muscular dystrophy patients
    Nathalie Doorenweerd
    Department of Radiology, C J Gorter Center for High Field MRI, Leiden University Medical Center, Leiden, The Netherlands Leiden Institute for Brain and Cognition, Leiden, The Netherlands Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands Electronic address
    Neuromuscul Disord . 2016
    ..No correlation between cerebral blood flow and age was found. Our results indicate that cerebral perfusion is reduced in Duchenne muscular dystrophy patients independent of the reduced grey matter volume...
  14. doi request reprint T2 relaxation times are increased in Skeletal muscle of DMD but not BMD patients
    Beatrijs H Wokke
    Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands
    Muscle Nerve 53:38-43. 2016
    ..MRI skeletal muscle T2 relaxation times as a representation of edema/inflammation could be quantitative outcome parameters for such trials...
  15. doi request reprint Exercise and type 2 diabetes mellitus: changes in tissue-specific fat distribution and cardiac function
    Jacqueline T Jonker
    Departments of Endocrinology and Metabolism, Radiology, and Nephrology, Leiden University Medical Center, C3 R, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands Department of Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands Department of Cardiology, Tjongerschans Hospital, Heerenveen, The Netherlands Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands
    Radiology 269:434-42. 2013
    ..To prospectively assess the effects of an exercise intervention on organ-specific fat accumulation and cardiac function in type 2 diabetes mellitus...
  16. doi request reprint Subject tolerance of 7 T MRI examinations
    Maarten J Versluis
    C J Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    J Magn Reson Imaging 38:722-5. 2013
    ..To determine the subjective experiences and the sources of discomfort for subjects undergoing 7 T magnetic resonance imaging (MRI) examinations on a whole-body 7 T system in a hospital setting..
  17. doi request reprint Proton observed phosphorus editing (POPE) for in vivo detection of phospholipid metabolites
    Jannie P Wijnen
    Department of Radiology, University Medical Centre Utrecht, Utrecht, The Netherlands
    NMR Biomed 29:1222-30. 2016
    ..POPE can be used for enhanced detection of (1) H-(31) P coupled metabolites in vivo. Copyright © 2015 John Wiley & Sons, Ltd. ..
  18. doi request reprint Comparison of dixon and T1-weighted MR methods to assess the degree of fat infiltration in duchenne muscular dystrophy patients
    Beatrijs H Wokke
    Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands
    J Magn Reson Imaging 38:619-24. 2013
    ....
  19. pmc Phosphorylated guanidinoacetate partly compensates for the lack of phosphocreatine in skeletal muscle of mice lacking guanidinoacetate methyltransferase
    Hermien E Kan
    Department of Radiology, University Medical Centre Nijmegen, Geert Grooteplein 10, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    J Physiol 560:219-29. 2004
    ..It is argued that absence of Cr causes the higher relative P(i) concentration also observed in animals lacking muscle CK, indicating an important role of the CK system in P(i) homeostasis...
  20. doi request reprint Reduced cerebral gray matter and altered white matter in boys with Duchenne muscular dystrophy
    Nathalie Doorenweerd
    Department of Radiology, C J Gorter Center for High Field MRI, Leiden University Medical Center, Leiden Leiden Institute for Brain and Cognition, Leiden Department of Neurology, Leiden University Medical Center, Leiden
    Ann Neurol 76:403-11. 2014
    ..We used quantitative magnetic resonance (MR) imaging to study brain microstructure in DMD...
  21. pmc Distinct disease phases in muscles of facioscapulohumeral dystrophy patients identified by MR detected fat infiltration
    Barbara H Janssen
    Department of Radiology, Radboud University Medical Center, Nijmegen, The Netherlands
    PLoS ONE 9:e85416. 2014
    ..Fat replacement then relatively rapidly spreads over the whole muscle. ..
  22. pmc Exploratory 7-Tesla magnetic resonance spectroscopy in Huntington's disease provides in vivo evidence for impaired energy metabolism
    Simon J A van den Bogaard
    Department of Neurology, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands
    J Neurol 258:2230-9. 2011
    ..These findings not only give insight into neuropathological changes in HD but also indicate that MRS can possibly be applied in future clinical trails to evaluate medication targeted at specific metabolic processes...
  23. doi request reprint Fast multistation water/fat imaging at 3T using DREAM-based RF shimming
    Melissa T Hooijmans
    Department of Radiology, C J Gorter Center for High Field MRI, LUMC, Leiden, The Netherlands
    J Magn Reson Imaging 42:217-23. 2015
    ..To show the effect, efficiency, and image quality improvements achievable by Dual Refocusing Echo Acquisition Mode (DREAM)-based B1+ shimming in whole-body magnetic resonance imaging (MRI) at 3T using the example of water/fat imaging...