J W Jukema

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint [The availability of only one statin is inadequate]
    J W Jukema
    Leids Universitair Medisch Centrum, afd Cardiologie, C5 P, Postbus 9600, 2300 RC Leiden
    Ned Tijdschr Geneeskd 149:2773-4. 2005
  2. ncbi request reprint LDL-C/HDL-C ratio in subjects with cardiovascular disease and a low HDL-C: results of the RADAR (Rosuvastatin and Atorvastatin in different Dosages And Reverse cholesterol transport) study
    J Wouter Jukema
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Curr Med Res Opin 21:1865-74. 2005
  3. doi request reprint Antiplatelet therapy in patients with ST-elevation myocardial infarction undergoing myocardial revascularisation: beyond clopidogrel
    J Wouter Jukema
    Department of Cardiology, Leiden University Medical Centre, Leiden, The Netherlands
    Curr Med Res Opin 28:203-11. 2012
  4. doi request reprint Contemporary registries on P2Y12 inhibitors in patients with acute coronary syndromes in Europe: overview and methodological considerations
    J Wouter Jukema
    Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, ZA 2333 Leiden, The Netherlands
    Eur Heart J Cardiovasc Pharmacother 1:232-44. 2015
  5. pmc Soluble Klotho is not independently associated with cardiovascular disease in a population of dialysis patients
    Maurits S Buiten
    Department of Nephrology, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    BMC Nephrol 15:197. 2014
  6. pmc Scarcity of atrial fibrillation in a traditional African population: a community-based study
    Jacob J E Koopman
    Department of Gerontology and Geriatrics, Postal zone C7 Q, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    BMC Cardiovasc Disord 14:87. 2014
  7. pmc Asymmetric dimethylarginine (ADMA) levels display a morning peak in patients with acute myocardial infarction
    Sandrin C Bergheanu
    Department of Cardiology, Leiden University Medical Center, The Netherlands
    Dis Markers 30:245-52. 2011
  8. pmc Factor VII Activating Protease Polymorphism (G534E) Is Associated with Increased Risk for Stroke and Mortality
    Stella Trompet
    Department of Cardiology, Leiden University Medical Center, C5 P, P O Box 9600, 2300 RC Leiden, The Netherlands
    Stroke Res Treat 2011:424759. 2011
  9. pmc Left ventricular diastolic dysfunction in dialysis patients assessed by novel speckle tracking strain rate analysis: prevalence and determinants
    Mihaly K de Bie
    Department of Cardiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Int J Nephrol 2012:963504. 2012
  10. pmc Systematic testing of literature reported genetic variation associated with coronary restenosis: results of the GENDER Study
    Jeffrey J W Verschuren
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 7:e42401. 2012

Detail Information

Publications174 found, 100 shown here

  1. ncbi request reprint [The availability of only one statin is inadequate]
    J W Jukema
    Leids Universitair Medisch Centrum, afd Cardiologie, C5 P, Postbus 9600, 2300 RC Leiden
    Ned Tijdschr Geneeskd 149:2773-4. 2005
    ..Competition between compounds is essential for providing best patient care. Thus the availability of only one statin was and continues to be inadequate for this purpose...
  2. ncbi request reprint LDL-C/HDL-C ratio in subjects with cardiovascular disease and a low HDL-C: results of the RADAR (Rosuvastatin and Atorvastatin in different Dosages And Reverse cholesterol transport) study
    J Wouter Jukema
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Curr Med Res Opin 21:1865-74. 2005
    ..Low HDL-C levels in patients with coronary artery disease are associated with a high risk for cardiovascular events...
  3. doi request reprint Antiplatelet therapy in patients with ST-elevation myocardial infarction undergoing myocardial revascularisation: beyond clopidogrel
    J Wouter Jukema
    Department of Cardiology, Leiden University Medical Centre, Leiden, The Netherlands
    Curr Med Res Opin 28:203-11. 2012
    ..Despite revascularisation, outcomes among patients presenting with ST-elevation myocardial infarction (STEMI) remain suboptimal...
  4. doi request reprint Contemporary registries on P2Y12 inhibitors in patients with acute coronary syndromes in Europe: overview and methodological considerations
    J Wouter Jukema
    Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, ZA 2333 Leiden, The Netherlands
    Eur Heart J Cardiovasc Pharmacother 1:232-44. 2015
    ..It sets the basis for upcoming publications that will focus on effectiveness and safety of the antiplatelets used. ..
  5. pmc Soluble Klotho is not independently associated with cardiovascular disease in a population of dialysis patients
    Maurits S Buiten
    Department of Nephrology, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    BMC Nephrol 15:197. 2014
    ..The purpose of the present study was to determine the relationship between serum Klotho (sKlotho) and the presence of CVD in dialysis patients...
  6. pmc Scarcity of atrial fibrillation in a traditional African population: a community-based study
    Jacob J E Koopman
    Department of Gerontology and Geriatrics, Postal zone C7 Q, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    BMC Cardiovasc Disord 14:87. 2014
    ..Atrial fibrillation has almost exclusively been studied in western populations where these risk factors are widely present. Therefore, we studied the epidemiology of atrial fibrillation in a traditional African community...
  7. pmc Asymmetric dimethylarginine (ADMA) levels display a morning peak in patients with acute myocardial infarction
    Sandrin C Bergheanu
    Department of Cardiology, Leiden University Medical Center, The Netherlands
    Dis Markers 30:245-52. 2011
    ..In conclusion, ADMA levels display a 24-hour variation with a significant morning peak in patients with acute myocardial infarction. These findings may relate ADMA levels to the acute onset of thrombotic cardiovascular events...
  8. pmc Factor VII Activating Protease Polymorphism (G534E) Is Associated with Increased Risk for Stroke and Mortality
    Stella Trompet
    Department of Cardiology, Leiden University Medical Center, C5 P, P O Box 9600, 2300 RC Leiden, The Netherlands
    Stroke Res Treat 2011:424759. 2011
    ..The possible protective effect on restenosis could be the result of reduced activation of zymogens, which are involved in hemostasis and matrix remodeling...
  9. pmc Left ventricular diastolic dysfunction in dialysis patients assessed by novel speckle tracking strain rate analysis: prevalence and determinants
    Mihaly K de Bie
    Department of Cardiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Int J Nephrol 2012:963504. 2012
    ..Left ventricular mass and pulse wave velocity were the only determinants of diastolic dysfunction in these patients...
  10. pmc Systematic testing of literature reported genetic variation associated with coronary restenosis: results of the GENDER Study
    Jeffrey J W Verschuren
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 7:e42401. 2012
    ..The aim of the current study was to analyze the joined effect of previously in literature reported candidate genes for restenosis in the GENetic DEterminants of Restenosis (GENDER) databank...
  11. pmc Non-homologous end-joining pathway associated with occurrence of myocardial infarction: gene set analysis of genome-wide association study data
    Jeffrey J W Verschuren
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 8:e56262. 2013
    ..Defects in DNA repair mechanisms may therefore increase the risk of CVD events. We examined whether the joints effect of common genetic variants in 5 DNA repair pathways may influence the risk of CVD events...
  12. pmc CT coronary angiography is feasible for the assessment of coronary artery disease in chronic dialysis patients, despite high average calcium scores
    Mihaly K de Bie
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 8:e67936. 2013
    ..However, extensive coronary calcification, often present in this patient group, might hamper adequate lumen evaluation. The objective of this study was to assess the feasibility of CT-angiography in this patient group...
  13. pmc Pathway analysis using genome-wide association study data for coronary restenosis--a potential role for the PARVB gene
    Jeffrey J W Verschuren
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 8:e70676. 2013
    ....
  14. doi request reprint The controversies of statin therapy: weighing the evidence
    J Wouter Jukema
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    J Am Coll Cardiol 60:875-81. 2012
    ..We, therefore, suggest that clinical practice for statin therapy should not be changed on the basis of the most recent Food and Drug Administration informational warnings...
  15. doi request reprint Restenosis after PCI. Part 2: prevention and therapy
    J Wouter Jukema
    Department of Cardiology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Nat Rev Cardiol 9:79-90. 2011
    ..In this Review we provide an overview of the latest innovations for optimizing outcomes of coronary stenting, and up-to-date information about prevention and treatment of in-stent restenosis...
  16. pmc Relationship between vascular stiffness and stress myocardial perfusion imaging in asymptomatic patients with diabetes
    Cornelis J Roos
    Department of Cardiology, C5 P, Leiden University Medical Center, Postbus 9600, 2300 RC, Leiden, The Netherlands
    Eur J Nucl Med Mol Imaging 38:2050-7. 2011
    ....
  17. pmc Replication of LDL GWAs hits in PROSPER/PHASE as validation for future (pharmaco)genetic analyses
    Stella Trompet
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    BMC Med Genet 12:131. 2011
    ..In this report we first describe the rationale of the PROSPER/PHASE project and second show that the PROSPER/PHASE study can be used to study pharmacogenetics in the elderly...
  18. pmc Incident venous thromboembolic events in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER)
    Dilys J Freeman
    Centre of Population and Health Sciences, University of Glasgow, Glasgow, UK
    BMC Geriatr 11:8. 2011
    ..We aimed to determine the effect of pravastatin on incident VTE in older people; we also studied the impact of clinical and plasma risk variables...
  19. pmc Estimating effects of rare haplotypes on failure time using a penalized Cox proportional hazards regression model
    Olga W Souverein
    Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, P O Box 22700, 1100 DE, Amsterdam, The Netherlands
    BMC Genet 9:9. 2008
    ....
  20. pmc TRAF1/C5 polymorphism is not associated with increased mortality in rheumatoid arthritis: two large longitudinal studies
    Jessica A B van Nies
    Department of Rheumatology, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Arthritis Res Ther 12:R38. 2010
    ..As TRAF1/C5 associated mortality may not be restricted to RA, we also studied a large cohort of non-RA patients...
  21. ncbi request reprint Tailored therapy to fit individual profiles. Genetics and coronary artery disease
    J W Jukema
    Department of Cardiology, C5 P, Leiden University Medical Center, The Netherlands
    Ann N Y Acad Sci 902:17-24; discussion 24-6. 2000
    ..Both in terms of the huge costs of drugs to society and in terms of needless medicalization, genotyping in order to tailor therapy might become a routine part of risk management earlier than we think...
  22. ncbi request reprint Impact of simultaneous pancreas and kidney transplantation on progression of coronary atherosclerosis in patients with end-stage renal failure due to type 1 diabetes
    J Wouter Jukema
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Diabetes Care 25:906-11. 2002
    ..However, no data are available on progression of coronary atherosclerosis after SPK...
  23. ncbi request reprint Variants of toll-like receptor 4 modify the efficacy of statin therapy and the risk of cardiovascular events
    S Matthijs Boekholdt
    Leiden University Medical Center, Department of Cardiology C5 P, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands
    Circulation 107:2416-21. 2003
    ....
  24. ncbi request reprint Amlodipine and atorvastatin in atherosclerosis: a review of the potential of combination therapy
    J Wouter Jukema
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Expert Opin Pharmacother 5:459-68. 2004
    ....
  25. ncbi request reprint -455G/A polymorphism and preprocedural plasma levels of fibrinogen show no association with the risk of clinical restenosis in patients with coronary stent placement
    Pascalle S Monraats
    Department of Cardiology, Leiden University Medical Center, The Netherlands
    Thromb Haemost 93:564-9. 2005
    ..Therefore, these parameters are not worthwhile for stratifying patients at risk for restenosis pre-stenting...
  26. doi request reprint Lipid goals among patients with diabetes or metabolic syndrome: Lipid Treatment Assessment Project (L-TAP) 2
    J Wouter Jukema
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Curr Med Res Opin 26:2589-97. 2010
    ..This analysis of the Lipid Treatment Assessment Project 2 population compared lipid goal attainment by diabetes and metabolic syndrome status...
  27. doi request reprint Restenosis after PCI. Part 1: pathophysiology and risk factors
    J Wouter Jukema
    Department of Cardiology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Nat Rev Cardiol 9:53-62. 2011
    ..In this Review, we will evaluate the available evidence on the pathophysiological mechanisms of restenosis and provide an overview of the various risk factors, together with the possible clinical application of this knowledge...
  28. doi request reprint Age- and gender-specific differences in the prognostic value of CT coronary angiography
    Kai Hang Yiu
    Department of Cardiology, Leiden University Medical Center, The Netherlands
    Heart 98:232-7. 2012
    ..To evaluate the potential age- and gender-specific differences in the incidence and prognostic value of coronary artery disease (CAD) in patients undergoing CT coronary angiography (CTA)...
  29. pmc Performance and efficacy of 320-row computed tomography coronary angiography in patients presenting with acute chest pain: results from a clinical registry
    J E van Velzen
    Department of Cardiology, Leiden University Medical Center, Postal Zone C5 P, P O Box 9600, 2333 ZA, Leiden, The Netherlands
    Int J Cardiovasc Imaging 28:865-76. 2012
    ..Importantly, normal or non-significant CAD on CTA predicted a low rate of adverse cardiovascular events and favorable outcome during follow-up...
  30. doi request reprint Lymphotoxin-alpha C804A polymorphism is a risk factor for stroke. The PROSPER study
    S Trompet
    Department of Cardiology, Leiden University Medical Centre, Leiden, The Netherlands
    Exp Gerontol 43:801-5. 2008
    ..02). The C804A polymorphism in the LTA gene associates with clinical stroke, especially in men. But further research is warranted to confirm our results...
  31. ncbi request reprint Acyl-CoA:cholesterol acyltransferase inhibitor avasimibe reduces atherosclerosis in addition to its cholesterol-lowering effect in ApoE*3-Leiden mice
    D J Delsing
    Gaubius Laboratory, TNO-PG, Leiden, The Netherlands
    Circulation 103:1778-86. 2001
    ..Because monocyte adherence to the endothelium and lesion severity were also reduced by avasimibe, treatment with avasimibe may result in higher plaque stability and therefore a reduced risk of plaque rupture...
  32. doi request reprint Circulating interleukin-6 concentration and cognitive decline in old age: the PROSPER study
    S P Mooijaart
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    J Intern Med 274:77-85. 2013
    ..The objective of this study was to investigate the associations between both high concentration of IL-6 and the -174 promoter polymorphism, and increased cognitive decline in old age...
  33. doi request reprint An unexpected intriguing effect of Toll-like receptor regulator RP105 (CD180) on atherosclerosis formation with alterations on B-cell activation
    J C Karper
    From the Department of Surgery J C K, M M E, M R d V, J W J, P H A Q, Einthoven Laboratory for Experimental Vascular Medicine J C K, M M E, M R d V, P H A Q, Department of Cardiology M M E, J W J, and Department of Immunohematology and Blood Transfusion A R, R A, Leiden University Medical Center, Leiden, The Netherlands Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands S C A d J Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands S C A d J, I B, P J v S, J K Inserm U970, Paris Cardiovascular Research Center, Paris, France Z M Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria C J B and Center for Molecular Medicine CeMM of the Austrian Academy of Sciences, Vienna, Austria C J B
    Arterioscler Thromb Vasc Biol 33:2810-7. 2013
    ..We aimed to identify a role of TLR accessory molecule RP105 on circulating cells in atherosclerotic plaque formation...
  34. pmc Non-invasive assessment of atherosclerotic coronary lesion length using multidetector computed tomography angiography: comparison to quantitative coronary angiography
    J E van Velzen
    Department of Cardiology, Leiden University Medical Center, Postal Zone C5 P, P O Box 9600, 2333 ZA Leiden, The Netherlands
    Int J Cardiovasc Imaging 28:2065-71. 2012
    ..001). Lesion length assessed by CTA is longer than that assessed by ICA. Possibly, CTA provides more accurate lesion length assessment than ICA and may facilitate improved guidance of percutaneous treatment of coronary lesions...
  35. doi request reprint Plaque type and composition as evaluated non-invasively by MSCT angiography and invasively by VH IVUS in relation to the degree of stenosis
    J E van Velzen
    Department of Cardiology, Leiden University Medical Centre, Leiden, The Netherlands
    Heart 95:1990-6. 2009
    ..However, the relation between plaque composition and severity of stenosis remains largely unknown...
  36. pmc Matrix metalloproteinases 2 and 3 gene polymorphisms and the risk of target vessel revascularization after percutaneous coronary intervention: Is there still room for determining genetic variation of MMPs for assessment of an increased risk of restenosis?
    J J W Verschuren
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Dis Markers 29:265-73. 2010
    ..The current study examines whether multiple single nucleotide polymorphisms (SNPs), covering the full genomic region of MMP2 and MMP3, were associated with restenosis in the GENDER study population...
  37. ncbi request reprint -455G/A polymorphism of the beta-fibrinogen gene is associated with the progression of coronary atherosclerosis in symptomatic men: proposed role for an acute-phase reaction pattern of fibrinogen. REGRESS group
    M P de Maat
    Gaubius Laboratory TNO PG, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 18:265-71. 1998
    ....
  38. ncbi request reprint Effect of the stromelysin-1 promoter on efficacy of pravastatin in coronary atherosclerosis and restenosis
    M P de Maat
    Gaubius Laboratory TNO PG, Leiden, The Netherlands
    Am J Cardiol 83:852-6. 1999
    ..This variant may therefore act as a predictor, not only of disease progression, but also of response to therapy and risk of restenosis...
  39. ncbi request reprint Raman spectroscopic evaluation of the effects of diet and lipid-lowering therapy on atherosclerotic plaque development in mice
    S W van De Poll
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 21:1630-5. 2001
    ..This study encourages Raman spectroscopy for the quantitative investigation of atherosclerosis and lipid-lowering therapy in larger animals or humans in vivo...
  40. doi request reprint Clinical application of CT coronary angiography: state of the art
    F R de Graaf
    Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Heart Lung Circ 19:107-16. 2010
    ....
  41. doi request reprint Genetic variation in the interleukin-1 beta-converting enzyme associates with cognitive function. The PROSPER study
    S Trompet
    Department of Gerontology and Geriatrics, C 2 R, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands
    Brain 131:1069-77. 2008
    ..This suggests that low levels of IL-1 beta are protective for memory and learning deficits. Inhibition of ICE may therefore be an important therapeutic target for maintaining cognitive function in old age...
  42. doi request reprint Annexin A5 prevents post-interventional accelerated atherosclerosis development in a dose-dependent fashion in mice
    M M Ewing
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Atherosclerosis 221:333-40. 2012
    ..Here, we report a therapeutic role for AnxA5 in post-interventional vascular remodeling in a mouse model mimicking percutaneous coronary intervention (PCI)...
  43. ncbi request reprint Lesional overexpression of matrix metalloproteinase-9 promotes intraplaque hemorrhage in advanced lesions but not at earlier stages of atherogenesis
    R de Nooijer
    Division of Biopharmaceutics, Leiden University, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 26:340-6. 2006
    ..This study aims to assess the effect of MMP-9 on plaque stability in apolipoprotein E-deficient mice at different stages of plaque progression...
  44. ncbi request reprint Micro stent I, initial results, and six months follow-up by quantitative coronary angiography
    M J Schalij
    Department of Cardiology, University Hospital, Leiden, The Netherlands
    Cathet Cardiovasc Diagn 43:19-27; discussion 28. 1998
    ..90+/-0.68 mm. The net gain was 1.26+/-0.90 mm. The restenosis rate (diameter stenosis > 50% at FU) was 13%. This study demonstrates high procedural and late success rates of Micro stent implantations...
  45. ncbi request reprint Pravastatin reduces restenosis two years after percutaneous transluminal coronary angioplasty (REGRESS trial)
    H J Mulder
    Department of Cardiology, Leiden University Medical Center, The Netherlands
    Am J Cardiol 86:742-6. 2000
    ..001). Risk reduction for all events was 58%. We conclude that treatment with pravastatin reduces 2-year clinical and angiographic restenosis...
  46. ncbi request reprint Common variants of multiple genes that control reverse cholesterol transport together explain only a minor part of the variation of HDL cholesterol levels
    S M Boekholdt
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Clin Genet 69:263-70. 2006
    ..Multiple environmental and genetic influences on HDL-C plasma levels still have to be elucidated...
  47. doi request reprint A single dose of erythropoietin in ST-elevation myocardial infarction
    Adriaan A Voors
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Eur Heart J 31:2593-600. 2010
    ..032). Conclusion A single high dose of EPO after a successful PCI for a STEMI did not improve LVEF after 6 weeks. However, the use of EPO was related to less major adverse cardiovascular events and a favourable clinical safety profile...
  48. doi request reprint Progression of brain atrophy and cognitive decline in diabetes mellitus: a 3-year follow-up
    S G C van Elderen
    Department of Radiology, Leiden University Medical Center, RC, Leiden, The Netherlands
    Neurology 75:997-1002. 2010
    ..To investigate progression of MRI-assessed manifestations of cerebral degeneration related to cognitive changes in a population of elderly patients with diabetes mellitus (DM) compared to age-matched control subjects...
  49. ncbi request reprint Genetic variation in the rate-limiting enzyme in cholesterol catabolism (cholesterol 7alpha-hydroxylase) influences the progression of atherosclerosis and risk of new clinical events
    Maaike K Hofman
    TNO Prevention and Health, Gaubius Laboratory, Leiden, The Netherlands
    Clin Sci (Lond) 108:539-45. 2005
    ....
  50. doi request reprint In-ambulance abciximab administration in STEMI patients prior to primary PCI is associated with smaller infarct size, improved LV function and lower incidence of heart failure: results from the Leiden MISSION! acute myocardial infarction treatment optimiz
    Ayman K M Hassan
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Catheter Cardiovasc Interv 74:335-43. 2009
    ..Our aim was to evaluate the effects of early abciximab administration in the ambulance on immediate, short, and long term outcomes...
  51. ncbi request reprint Cholesteryl ester transfer protein TaqIB variant, high-density lipoprotein cholesterol levels, cardiovascular risk, and efficacy of pravastatin treatment: individual patient meta-analysis of 13,677 subjects
    S M Boekholdt
    Department of Cardiology, Academic Medical Center, Academic Medical Center, Amsterdam, The Netherlands
    Circulation 111:278-87. 2005
    ..In addition, an interaction has been implicated between this genetic variant and pravastatin treatment, but this has not been confirmed...
  52. ncbi request reprint Prevalence of coronary artery disease and plaque morphology assessed by multi-slice computed tomography coronary angiography and calcium scoring in asymptomatic patients with type 2 diabetes
    A J H A Scholte
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Heart 94:290-5. 2008
    ..In addition, the relation between calcium score and MSCT findings was explored...
  53. ncbi request reprint Differential effects of amlodipine and atorvastatin treatment and their combination on atherosclerosis in ApoE*3-Leiden transgenic mice
    Dianne J M Delsing
    Gaubius Laboratory, TNO PG, Leiden, The Netherlands
    J Cardiovasc Pharmacol 42:63-70. 2003
    ..Atorvastatin was shown to have strong antiatherosclerotic effects, and cotreatment with amlodipine may potentiate the antiatherosclerotic effect of atorvastatin...
  54. pmc Non-response to (statin) therapy: the importance of distinguishing non-responders from non-adherers in pharmacogenetic studies
    S Trompet
    Department of Cardiology, C5 R, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands
    Eur J Clin Pharmacol 72:431-7. 2016
    ....
  55. pmc Comprehensive cardiac assessment with multislice computed tomography: evaluation of left ventricular function and perfusion in addition to coronary anatomy in patients with previous myocardial infarction
    M M Henneman
    Department of Cardiology, Leiden University Medical Center, The Netherlands
    Heart 92:1779-83. 2006
    ..To evaluate a comprehensive multislice computed tomography (MSCT) protocol in patients with previous infarction, including assessment of coronary artery stenoses, left ventricular (LV) function and perfusion...
  56. pmc Non-invasive cardiac imaging techniques and vascular tools for the assessment of cardiovascular disease in type 2 diabetes mellitus
    R Djaberi
    Department of Cardiology, C5 P33, Leiden University Medical Center, Postbus 9600, 2300 RC, Leiden, The Netherlands
    Diabetologia 51:1581-93. 2008
    ..Therefore, we propose an algorithm for the screening of asymptomatic diabetic patients, the first step of which consists of coronary artery calcium score assessment and exercise ECG...
  57. doi request reprint Leukocyte cathepsin S is a potent regulator of both cell and matrix turnover in advanced atherosclerosis
    R de Nooijer
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 29:188-94. 2009
    ..To address its role in advanced lesion composition, we generated chimeric LDLr(-/-) mice deficient in leukocyte CatS by transplantation with CatS(-/-)xLDLr(-/-) or with LDLr(-/-) bone marrow and administered a high-fat diet...
  58. ncbi request reprint Multi-slice computed tomography in the evaluation of patients with acute chest pain
    J D Schuijf
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Acute Card Care 9:214-21. 2007
    ..The purpose of the present review is to discuss the potential roles of calcium scoring and non-invasive coronary angiography in patients presenting with suspected ACS...
  59. ncbi request reprint Multi-slice computed tomography coronary angiography: anatomic vs functional assessment in clinical practice
    J M van Werkhoven
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Minerva Cardioangiol 56:215-26. 2008
    ..Importantly, these investigations should result in the development of comprehensive guidelines on the use of CTA in clinical practice as well...
  60. doi request reprint Multislice computed tomography coronary angiography for risk stratification in patients with an intermediate pretest likelihood
    J M van Werkhoven
    Department of Cardiology, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Heart 95:1607-11. 2009
    ....
  61. ncbi request reprint An integrated evaluation of endothelial constitutive nitric oxide synthase polymorphisms and coronary artery disease in men
    Willem R P Agema
    Department of Cardiology, Leiden University Medical Center, The Netherlands
    Clin Sci (Lond) 107:255-61. 2004
    ..We conclude that the E/D298 polymorphism is most consistently associated with CAD, but not with progression of atherosclerosis. The E allele is associated with CAD and MI, whereas the D allele is associated with ischaemia...
  62. ncbi request reprint Cardiac multidetector-row computed tomography in patients with unstable angina
    Martijn S Dirksen
    Department of Radiology, Leiden University Medical Center, The Netherlands
    Am J Cardiol 95:457-61. 2005
    ..High accuracies in excluding significant coronary artery disease and in confirming normal LV function were observed, suggesting potential clinical use for screening of patients who present with symptoms of unstable angina...
  63. ncbi request reprint Assessment of left ventricular volumes and ejection fraction with 16-slice multi-slice computed tomography; comparison with 2D-echocardiography
    J D Schuijf
    Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Int J Cardiol 116:201-5. 2007
    ..Accordingly, the purpose of the present study was to validate assessment of LV function with MSCT using 2D-echocardiography in a large cohort of patients...
  64. doi request reprint Abdominal adiposity largely explains associations between insulin resistance, hyperglycemia and subclinical atherosclerosis: the NEO study
    Karin B Gast
    Department of Clinical Epidemiology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Atherosclerosis 229:423-9. 2013
    ..Furthermore, adiposity may be responsible for observed associations. Our aim was to study the relative contributions of adiposity, insulin resistance and hyperglycemia to subclinical atherosclerosis...
  65. doi request reprint Genetic variation in PCAF, a key mediator in epigenetics, is associated with reduced vascular morbidity and mortality: evidence for a new concept from three independent prospective studies
    Douwe Pons
    Department of Cardiology, Leiden University Medical Center, RC Leiden, The Netherlands
    Heart 97:143-50. 2011
    ....
  66. ncbi request reprint Functional evaluation of lipid-lowering therapy by pravastatin in the Regression Growth Evaluation Statin Study (REGRESS)
    W R Aengevaeren
    Department of Cardiology, University Hospital Nijmegen, The Netherlands
    Circulation 96:429-35. 1997
    ..The effect of lipid-lowering therapy on the functional state of the coronary circulation is less well known. The purpose of this study was to evaluate this effect...
  67. pmc Pravastatin and endothelium dependent vasomotion after coronary angioplasty: the PREFACE trial
    H J Mulder
    Department of Cardiology, Leiden University Medical Centre, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, Netherlands
    Heart 86:533-9. 2001
    ..A significant beneficial effect of pravastatin on endothelial function could not be shown, but in the dilated segments there was a trend towards a beneficial treatment effect in the pravastatin group...
  68. ncbi request reprint [Screening of asymptomatic individuals for coronary disease using CT-calcium measurement in the coronary arteries]
    J D Schuijf
    Leids Universitair Medisch Centrum, afd Cardiologie, Leiden
    Ned Tijdschr Geneeskd 150:597-600. 2006
    ..Hard endpoints will be myocardial infarction, stroke and mortality due to cardiovascular disease...
  69. ncbi request reprint Gender influence on the diagnostic accuracy of 64-slice multislice computed tomography coronary angiography for detection of obstructive coronary artery disease
    G Pundziute
    Department of Cardiology, Leiden University Medical Centre, Leiden, The Netherlands
    Heart 94:48-52. 2008
    ..To compare the diagnostic accuracy of 64-slice multislice computed tomography (MSCT) coronary angiography between female and male patients using conventional coronary angiography as the reference standard...
  70. ncbi request reprint Effect of rosuvastatin versus atorvastatin treatment on paraoxonase-1 activity in men with established cardiovascular disease and a low HDL-cholesterol
    S C Bergheanu
    Leiden University Medical Center, Leiden, The Netherlands
    Curr Med Res Opin 23:2235-40. 2007
    ..Paraoxonase-1 (PON-1) is a high-density lipoprotein (HDL) associated enzyme involved in the protective mechanisms of HDL. Our aim was to compare the effect of treatment with rosuvastatin and atorvastatin on serum PON-1 activity...
  71. ncbi request reprint MR flow mapping in coronary artery bypass grafts: a validation study with Doppler flow measurements
    Susan E Langerak
    Dept of Cardiology, Leiden Univ Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Radiology 222:127-35. 2002
    ..To validate fast magnetic resonance (MR) flow mapping with intravascular Doppler flow measurements in vitro and in patients with nonstenotic and stenotic coronary artery bypass grafts...
  72. ncbi request reprint Raman spectroscopic investigation of atorvastatin, amlodipine, and both on atherosclerotic plaque development in APOE*3 Leiden transgenic mice
    Sweder W E van de Poll
    Department of Cardiology, C5 P, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Atherosclerosis 164:65-71. 2002
    ..No synergistic effect of the combination of amlodipine and atorvastatin on plaque development is demonstrated. This study encourages Raman spectroscopic evaluations of anti-atherosclerotic drugs in larger animals and humans in vivo...
  73. ncbi request reprint Interaction between a genetic variant of the platelet fibrinogen receptor and fibrinogen levels in determining the risk of cardiovascular events
    S Matthijs Boekholdt
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Am Heart J 147:181-6. 2004
    ..We investigated whether the effect of this genetic variant of the platelet fibrinogen receptor on the risk of cardiovascular events is affected by fibrinogen plasma levels...
  74. ncbi request reprint CETP gene variation: relation to lipid parameters and cardiovascular risk
    S Matthijs Boekholdt
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Curr Opin Lipidol 15:393-8. 2004
    ..Research on naturally occurring variants in the CETP gene has yielded numerous insights that have been relevant for understanding lipoprotein metabolism, and crucial to the development of pharmacological CETP inhibition...
  75. ncbi request reprint Feasibility of assessment of coronary stent patency using 16-slice computed tomography
    Joanne D Schuijf
    Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Am J Cardiol 94:427-30. 2004
    ..In conclusion, MSCT may be useful in the assessment of stent patency and may function as a gatekeeper before invasive diagnostic procedures...
  76. ncbi request reprint Noninvasive coronary imaging and assessment of left ventricular function using 16-slice computed tomography
    Joanne D Schuijf
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Cardiol 95:571-4. 2005
    ..In conclusion, 16-slice MSCT is a feasible modality for noninvasive evaluation and exclusion of coronary artery disease in patients who present with chest pain...
  77. ncbi request reprint Metabolic syndrome and risk of restenosis in patients undergoing percutaneous coronary intervention
    Jamal S Rana
    Department of Cardiology, Leiden University Medical Center, C5 P, P O Box 9600, 2300 RC Leiden, Netherlands
    Diabetes Care 28:873-7. 2005
    ..However, only limited data are available on the effect of metabolic syndrome on restenosis in patients undergoing percutaneous coronary intervention (PCI)...
  78. ncbi request reprint Early administration of abciximab in patients with acute myocardial infarction improves angiographic and clinical outcome after primary angioplasty
    Saskia L M A Beeres
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Catheter Cardiovasc Interv 65:478-83. 2005
    ..Abciximab pretreatment of patients with AMI for primary PCI results in better initial and final TIMI flow and tends to improve 6-month clinical outcome...
  79. ncbi request reprint Tumor necrosis factor-alpha plays an important role in restenosis development
    Pascalle S Monraats
    Department of Cardiology, Leiden University Medical Center, The Netherlands
    FASEB J 19:1998-2004. 2005
    ..Therefore, TNFalpha genotype may be used as a risk marker for restenosis and may contribute to individual patient screening prior to PCI in clinical practice. Inhibition of TNFalpha may be an anti-restenotic target strategy...
  80. ncbi request reprint Dual PPARalpha/gamma agonist tesaglitazar reduces atherosclerosis in insulin-resistant and hypercholesterolemic ApoE*3Leiden mice
    A Susanne M Zadelaar
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 26:2560-6. 2006
    ..We investigated whether the dual PPARalpha/gamma agonist tesaglitazar has anti-atherogenic effects in ApoE*3Leiden mice with reduced insulin sensitivity...
  81. doi request reprint Predictive value of multislice computed tomography variables of atherosclerosis for ischemia on stress-rest single-photon emission computed tomography
    Joella E van Velzen
    Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands
    Circ Cardiovasc Imaging 3:718-26. 2010
    ..The purpose of this study was to assess which variables of atherosclerosis on MSCT angiography are related to ischemia on MPI...
  82. ncbi request reprint Interleukin 10: a new risk marker for the development of restenosis after percutaneous coronary intervention
    P S Monraats
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Genes Immun 8:44-50. 2007
    ..Furthermore, they may provide a new targeting gene for drug-eluting stents...
  83. ncbi request reprint Dexamethasone-eluting stents for the prevention of in-stent restenosis: evidence for a differential effect in insulin-dependent and non-insulin-dependent diabetic patients
    B L van der Hoeven
    Department of Cardiology, C5 P, Leiden University Medical Center, Postbus 9600, 2300 RC, Leiden, The Netherlands
    Int J Cardiol 124:166-71. 2008
    ..We hypothesized that diabetic patients will benefit from dexamethasone-eluting stents, since local inflammation and consequently neointimal growth are suppressed and no systemic side effects will occur...
  84. ncbi request reprint Genetic variation in the interleukin-10 gene promoter and risk of coronary and cerebrovascular events: the PROSPER study
    S Trompet
    Department of Gerontology and Geriatrics, C 2 R, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Ann N Y Acad Sci 1100:189-98. 2007
    ..50 (1.04-2.17), P value = 0.02). Our study suggests that not only proinflammatory processes contribute to atherosclerosis, but that also anti-inflammatory cytokines may play an important role...
  85. doi request reprint Increased amygdalar and hippocampal volumes in elderly obese individuals with or at risk of cardiovascular disease
    Ralph L Widya
    Departments of Radiology, Leiden University Medical Center, Leiden, Netherlands
    Am J Clin Nutr 93:1190-5. 2011
    ..The basal ganglia, hippocampus, and thalamus are involved in the regulation of human feeding behavior. Recent studies have shown that obesity [body mass index (BMI; in kg/m(2)) > 30] is associated with loss of gray and white matter...
  86. doi request reprint T-cell co-stimulation by CD28-CD80/86 and its negative regulator CTLA-4 strongly influence accelerated atherosclerosis development
    M M Ewing
    Dept of Cardiology, Leiden University Medical Center LUMC, Leiden, The Netherlands Dept of Surgery, LUMC, Leiden, The Netherlands Einthoven Laboratory for Experimental Vascular Medicine, LUMC, Leiden, The Netherlands
    Int J Cardiol 168:1965-74. 2013
    ....
  87. pmc Associations between total cerebral blood flow and age related changes of the brain
    Adriaan C G M van Es
    Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 5:e9825. 2010
    ....
  88. pmc Hypermethylation at loci sensitive to the prenatal environment is associated with increased incidence of myocardial infarction
    Rudolf P Talens
    Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Int J Epidemiol 41:106-15. 2012
    ..Methylation at IL10, LEP, ABCA1, IGF2, INS and GNASAS was measured in DNA extracted from leucocytes using mass spectrometry...
  89. ncbi request reprint Diagnosis and management of anomalous origin of the right coronary artery from the left coronary sinus
    M A Bekedam
    Department of Cardiology, Free University Hospital Amsterdam, The Netherlands
    Int J Card Imaging 15:253-8; discussion 259. 1999
    ....
  90. ncbi request reprint CC chemokine ligand-5 (CCL5/RANTES) and CC chemokine ligand-18 (CCL18/PARC) are specific markers of refractory unstable angina pectoris and are transiently raised during severe ischemic symptoms
    A O Kraaijeveld
    Department of Cardiology and Einthoven Laboratory of Experimental Vascular Medicine C5 P, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Circulation 116:1931-41. 2007
    ..Therefore, we assessed chemokine patterns in a prospective cohort of patients with UAP...
  91. doi request reprint Reduced leucocyte cholesteryl ester transfer protein expression in acute coronary syndromes
    D Ye
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands
    J Intern Med 264:571-85. 2008
    ..The aim of the current study was to investigate the effect of acute coronary syndromes (ACS) on leucocyte CETP expression...
  92. pmc The dual PPARalpha/gamma agonist tesaglitazar blocks progression of pre-existing atherosclerosis in APOE*3Leiden.CETP transgenic mice
    J W A van der Hoorn
    TNO BioSciences, Leiden, The Netherlands
    Br J Pharmacol 156:1067-75. 2009
    ..cholesteryl ester transfer protein (E3L.CETP) transgenic mice...
  93. doi request reprint The tolerability and efficacy of low-dose simvastatin in statin-intolerant patients
    L E Degreef
    Section of Vascular Medicine, Department of Endocrinology and General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Intern Med 21:293-6. 2010
    ..Since vulnerability to dose related adverse events differ between subjects treated with statins we hypothesized low-dose simvastatin would be tolerated and effective in statin-intolerant patients...
  94. ncbi request reprint Plasma levels of cholesteryl ester transfer protein and the risk of future coronary artery disease in apparently healthy men and women: the prospective EPIC (European Prospective Investigation into Cancer and nutrition)-Norfolk population study
    S Matthijs Boekholdt
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Circulation 110:1418-23. 2004
    ..Evidence exists that the effect of CETP depends on metabolic context, in particular on triglyceride levels...
  95. ncbi request reprint Noninvasive evaluation of the coronary arteries with multislice computed tomography in hypertensive patients
    Joanne D Schuijf
    Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Hypertension 45:227-32. 2005
    ..This noninvasive approach may allow triage of patient treatment in terms of conservative versus invasive management...
  96. ncbi request reprint Noninvasive assessment of plaque characteristics with multislice computed tomography coronary angiography in symptomatic diabetic patients
    Gabija Pundziute
    Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Diabetes Care 30:1113-9. 2007
    ..The purpose of this study was to evaluate whether differences in the extent and composition of coronary plaques in patients with and without diabetes can be observed using multislice computed tomography (MSCT)...
  97. ncbi request reprint The influence of established genetic variation in the haemostatic system on clinical restenosis after percutaneous coronary interventions
    Douwe Pons
    Leiden University Medical Center, Department of Cardiology, C5 P, Albinusdreef 2, P O Box 9600, 2300 RC Leiden, The Netherlands
    Thromb Haemost 98:1323-8. 2007
    ..41, 95% CI: 0.19-0.86). Our findings indicate that polymorphisms in the factorV and PAI-1 genes may play a role in the process of restenosis...
  98. ncbi request reprint Lipidomic approach to evaluate rosuvastatin and atorvastatin at various dosages: investigating differential effects among statins
    Sandrin C Bergheanu
    Leiden University Medical Center, Leiden, The Netherlands
    Curr Med Res Opin 24:2477-87. 2008
    ....
  99. doi request reprint Prevalence of coronary artery disease across the Framingham risk categories: coronary artery calcium scoring and MSCT coronary angiography
    Gaetano Nucifora
    Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, P O Box 9600, Leiden, 2300 RC, The Netherlands
    J Nucl Cardiol 16:368-75. 2009
    ..However, data relating observations on CACS and MSCT coronary angiography to traditional risk assessment are scarce...
  100. pmc Bramwell-Hill modeling for local aortic pulse wave velocity estimation: a validation study with velocity-encoded cardiovascular magnetic resonance and invasive pressure assessment
    Jos J M Westenberg
    Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    J Cardiovasc Magn Reson 14:2. 2012
    ....