Menno Hoekstra

Summary

Affiliation: Leiden University
Country: The Netherlands

Publications

  1. doi request reprint Mouse models of disturbed HDL metabolism
    Menno Hoekstra
    Division of Biopharmaceutics, Gorlaeus Laboratories, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333CC, Leiden, The Netherlands
    Handb Exp Pharmacol 224:301-36. 2015
  2. doi request reprint Adrenal-specific scavenger receptor BI deficiency induces glucocorticoid insufficiency and lowers plasma very-low-density and low-density lipoprotein levels in mice
    Menno Hoekstra
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, PO Box 9502, 2300RA Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 33:e39-46. 2013
  3. pmc LCAT deficiency in mice is associated with a diminished adrenal glucocorticoid function
    Menno Hoekstra
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden, The Netherlands
    J Lipid Res 54:358-64. 2013
  4. doi request reprint FXR agonist GW4064 increases plasma glucocorticoid levels in C57BL/6 mice
    Menno Hoekstra
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, 2300 RA Leiden, The Netherlands
    Mol Cell Endocrinol 362:69-75. 2012
  5. doi request reprint Nonalcoholic fatty liver disease is associated with an altered hepatocyte microRNA profile in LDL receptor knockout mice
    Menno Hoekstra
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden, The Netherlands
    J Nutr Biochem 23:622-8. 2012
  6. ncbi request reprint Specific gene expression of ATP-binding cassette transporters and nuclear hormone receptors in rat liver parenchymal, endothelial, and Kupffer cells
    Menno Hoekstra
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, P O Box 9502, Leiden, Zuid Holland 2300 RA, The Netherlands
    J Biol Chem 278:25448-53. 2003
  7. pmc Scavenger receptor class B type I-mediated uptake of serum cholesterol is essential for optimal adrenal glucocorticoid production
    Menno Hoekstra
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, 2300RA Leiden, The Netherlands
    J Lipid Res 50:1039-46. 2009
  8. doi request reprint Plasma lipoproteins are required for both basal and stress-induced adrenal glucocorticoid synthesis and protection against endotoxemia in mice
    Menno Hoekstra
    Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden, The Netherlands
    Am J Physiol Endocrinol Metab 299:E1038-43. 2010
  9. doi request reprint Absence of HDL cholesteryl ester uptake in mice via SR-BI impairs an adequate adrenal glucocorticoid-mediated stress response to fasting
    Menno Hoekstra
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, 2300RA Leiden, The Netherlands
    J Lipid Res 49:738-45. 2008
  10. ncbi request reprint Microarray analysis indicates an important role for FABP5 and putative novel FABPs on a Western-type diet
    Menno Hoekstra
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, 2300 RA Leiden, The Netherlands
    J Lipid Res 47:2198-207. 2006

Collaborators

Detail Information

Publications52

  1. doi request reprint Mouse models of disturbed HDL metabolism
    Menno Hoekstra
    Division of Biopharmaceutics, Gorlaeus Laboratories, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333CC, Leiden, The Netherlands
    Handb Exp Pharmacol 224:301-36. 2015
    ....
  2. doi request reprint Adrenal-specific scavenger receptor BI deficiency induces glucocorticoid insufficiency and lowers plasma very-low-density and low-density lipoprotein levels in mice
    Menno Hoekstra
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, PO Box 9502, 2300RA Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 33:e39-46. 2013
    ..We determined the physiological consequences of adrenocortical-specific deletion of scavenger receptor BI (SR-BI) function in C57BL/6 wild-type mice...
  3. pmc LCAT deficiency in mice is associated with a diminished adrenal glucocorticoid function
    Menno Hoekstra
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden, The Netherlands
    J Lipid Res 54:358-64. 2013
    ..These findings further highlight the important novel role for HDL as cholesterol donor for the synthesis of glucocorticoids by the adrenals...
  4. doi request reprint FXR agonist GW4064 increases plasma glucocorticoid levels in C57BL/6 mice
    Menno Hoekstra
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, 2300 RA Leiden, The Netherlands
    Mol Cell Endocrinol 362:69-75. 2012
    ..Our findings suggest a novel role for FXR in the modulation of adrenal cholesterol metabolism and glucocorticoid synthesis in mice...
  5. doi request reprint Nonalcoholic fatty liver disease is associated with an altered hepatocyte microRNA profile in LDL receptor knockout mice
    Menno Hoekstra
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden, The Netherlands
    J Nutr Biochem 23:622-8. 2012
    ..Based upon our comparative gene and microRNA expression studies it is anticipated that miR-302a may prove to be a valuable therapeutic target in the regulation of hepatic fatty acid utilization and insulin resistance...
  6. ncbi request reprint Specific gene expression of ATP-binding cassette transporters and nuclear hormone receptors in rat liver parenchymal, endothelial, and Kupffer cells
    Menno Hoekstra
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, P O Box 9502, Leiden, Zuid Holland 2300 RA, The Netherlands
    J Biol Chem 278:25448-53. 2003
    ....
  7. pmc Scavenger receptor class B type I-mediated uptake of serum cholesterol is essential for optimal adrenal glucocorticoid production
    Menno Hoekstra
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, 2300RA Leiden, The Netherlands
    J Lipid Res 50:1039-46. 2009
    ..In conclusion, we have shown that CETP-mediated transfer of HDL-CE is not able to reverse adrenal insufficiency in SR-BI knockout mice. Thus, SR-BI-mediated uptake of serum cholesterol is essential for optimal adrenal function...
  8. doi request reprint Plasma lipoproteins are required for both basal and stress-induced adrenal glucocorticoid synthesis and protection against endotoxemia in mice
    Menno Hoekstra
    Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden, The Netherlands
    Am J Physiol Endocrinol Metab 299:E1038-43. 2010
    ..Therefore, it is suggested that plasma lipoproteins are required for optimal adrenal steroidogenesis and protection against endotoxemia in mice...
  9. doi request reprint Absence of HDL cholesteryl ester uptake in mice via SR-BI impairs an adequate adrenal glucocorticoid-mediated stress response to fasting
    Menno Hoekstra
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, 2300RA Leiden, The Netherlands
    J Lipid Res 49:738-45. 2008
    ....
  10. ncbi request reprint Microarray analysis indicates an important role for FABP5 and putative novel FABPs on a Western-type diet
    Menno Hoekstra
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, 2300 RA Leiden, The Netherlands
    J Lipid Res 47:2198-207. 2006
    ....
  11. doi request reprint Activation of the nuclear receptor PXR decreases plasma LDL-cholesterol levels and induces hepatic steatosis in LDL receptor knockout mice
    Menno Hoekstra
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, 2300RA Leiden, The Netherlands
    Mol Pharm 6:182-9. 2009
    ....
  12. pmc Scavenger receptor BI: a multi-purpose player in cholesterol and steroid metabolism
    Menno Hoekstra
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Einsteinweg 55, PO Box 9502, 2300RA Leiden, The Netherlands
    World J Gastroenterol 16:5916-24. 2010
    ..Studies using these mice have identified SR-BI as a multi-purpose player in cholesterol and steroid metabolism because it has distinct roles in reverse cholesterol transport, adrenal steroidogenesis, and platelet function...
  13. doi request reprint The peripheral blood mononuclear cell microRNA signature of coronary artery disease
    Menno Hoekstra
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Einsteinweg 55, P O Box 9502, 2300RA Leiden, The Netherlands
    Biochem Biophys Res Commun 394:792-7. 2010
    ..MicroRNAs are being used in the oncology field to characterize tumors and predict the survival of cancer patients. Here, we explored the potential of microRNAs as biomarkers for coronary artery disease (CAD) and acute coronary syndromes...
  14. doi request reprint The expression level of non-alcoholic fatty liver disease-related gene PNPLA3 in hepatocytes is highly influenced by hepatic lipid status
    Menno Hoekstra
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, Leiden, The Netherlands
    J Hepatol 52:244-51. 2010
    ..To gain insight into the potential function of PNPLA3 in liver, we have determined the effect of metabolic shifts on the hepatic expression profile of PNPLA3 in mice...
  15. ncbi request reprint Diet induced regulation of genes involved in cholesterol metabolism in rat liver parenchymal and Kupffer cells
    Menno Hoekstra
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, P O Box 9502, 2300 RA Leiden, The Netherlands
    J Hepatol 42:400-7. 2005
    ..In the present study, the effect of an atherogenic diet enriched in cholesterol and cholic acid on cellular hepatic cholesterol metabolism was studied...
  16. doi request reprint Independent protective roles for macrophage Abcg1 and Apoe in the atherosclerotic lesion development
    Bart Lammers
    Gorlaeus Leiden Amsterdam Center for Drug Research, Leiden University, The Netherlands
    Atherosclerosis 205:420-6. 2009
    ..A possible interaction between Abcg1 and Apoe in cholesterol efflux was postulated, but the potential combined action of these proteins on atherosclerotic lesion formation is unclear...
  17. ncbi request reprint Combined deletion of macrophage ABCA1 and ABCG1 leads to massive lipid accumulation in tissue macrophages and distinct atherosclerosis at relatively low plasma cholesterol levels
    Ruud Out
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Einsteinweg 55, 2333CC Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 28:258-64. 2008
    ..The purpose of this study was to evaluate the effect of the combined deletion of ABCA1 and ABCG1 expression in macrophages on foam cell formation and atherosclerosis...
  18. pmc Augmented atherogenesis in LDL receptor deficient mice lacking both macrophage ABCA1 and ApoE
    Bart Lammers
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, Leiden, The Netherlands
    PLoS ONE 6:e26095. 2011
    ..In contrast to apoA-I, apoE is secreted by macrophages and can, like apoA-I, induce ABCA1-mediated cholesterol efflux. Yet, the combined effect of macrophage ABCA1 and apoE on lesion development is unexplored...
  19. doi request reprint Restoration of high-density lipoprotein levels by cholesteryl ester transfer protein expression in scavenger receptor class B type I (SR-BI) knockout mice does not normalize pathologies associated with SR-BI deficiency
    Reeni B Hildebrand
    Leiden Amsterdam Center for Drug Research, Division of Biopharmaceutics, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 30:1439-45. 2010
    ..In this study, it was investigated whether introduction of cholesteryl ester transfer protein (CETP) can normalize HDL-C transport to the liver and reduce atherosclerosis in SR-BI knockout (KO) mice...
  20. ncbi request reprint Scavenger receptor class B type I is solely responsible for the selective uptake of cholesteryl esters from HDL by the liver and the adrenals in mice
    Ruud Out
    Leiden Amsterdam Center for Drug Research, Division of Biopharmaceutics, Gorlaeus Laboratories, Leiden University, 2300 RA Leiden, The Netherlands
    J Lipid Res 45:2088-95. 2004
    ..Thus, in vivo and in vitro, SR-BI is the sole molecule mediating the selective uptake of CE from HDL by the liver and the adrenals, making it the unique target to modulate reverse cholesterol transport...
  21. doi request reprint Enhanced foam cell formation, atherosclerotic lesion development, and inflammation by combined deletion of ABCA1 and SR-BI in Bone marrow-derived cells in LDL receptor knockout mice on western-type diet
    Ying Zhao
    Division of Biopharmaceutics, University Medical Center Groningen, The Netherlands
    Circ Res 107:e20-31. 2010
    ....
  22. ncbi request reprint Important role for bone marrow-derived cholesteryl ester transfer protein in lipoprotein cholesterol redistribution and atherosclerotic lesion development in LDL receptor knockout mice
    Miranda Van Eck
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, Leiden, The Netherlands
    Circ Res 100:678-85. 2007
    ..Most importantly, we show for the first time that bone marrow-derived CETP is an important contributor to total serum CETP activity and mass...
  23. ncbi request reprint Total body ABCG1 expression protects against early atherosclerotic lesion development in mice
    Ruud Out
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Einsteinweg 55, 2333CC Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 27:594-9. 2007
    ..To further define the role of ABCG1 in atherogenesis, we investigated in the current study the effect of total body deficiency of ABCG1 on atherosclerotic lesion development...
  24. ncbi request reprint Hepatic cell-specific ATP-binding cassette (ABC) transporter profiling identifies putative novel candidates for lipid homeostasis in mice
    Dan Ye
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands
    Atherosclerosis 196:650-8. 2008
    ..ABC-transporters play an important role in lipid trafficking. Therefore, hepatic expression patterns of ABC-transporters involved in the regulation of cholesterol metabolism were evaluated...
  25. ncbi request reprint Differential effects of scavenger receptor BI deficiency on lipid metabolism in cells of the arterial wall and in the liver
    Miranda Van Eck
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, PO Box 9502, 2300 RA Leiden, The
    J Biol Chem 278:23699-705. 2003
    ....
  26. ncbi request reprint Macrophage ABCG1 deletion disrupts lipid homeostasis in alveolar macrophages and moderately influences atherosclerotic lesion development in LDL receptor-deficient mice
    Ruud Out
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Einsteinweg 55, 2333CC Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 26:2295-300. 2006
    ..Its expression in macrophages is induced during cholesterol uptake in macrophages and by liver X receptor (LXR). The role of macrophage ABCG1 in atherosclerotic lesion development is, however, still unknown...
  27. doi request reprint The effect of ABCG1 deficiency on atherosclerotic lesion development in LDL receptor knockout mice depends on the stage of atherogenesis
    Illiana Meurs
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, Leiden, The Netherlands
    Atherosclerosis 221:41-7. 2012
    ..The objective of this study was to define the effect of ABCG1 deficiency during atherosclerotic lesion progression in LDL receptor knockout (LDLr(-/-)) mice...
  28. ncbi request reprint Scavenger receptor BI facilitates the metabolism of VLDL lipoproteins in vivo
    Miranda Van Eck
    Divison of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, Leiden, The Netherlands
    J Lipid Res 49:136-46. 2008
    ..In conclusion, SR-BI plays an important physiological role in the metabolism of VLDL (remnants)...
  29. ncbi request reprint HDL cholesterol levels are an important factor for determining the lifespan of erythrocytes
    Illiana Meurs
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden, The Netherlands
    Exp Hematol 33:1309-19. 2005
    ..The objective of the current study was to delineate the mechanism underlying development of anemia in the absence of SR-BI...
  30. doi request reprint Adrenalectomy stimulates the formation of initial atherosclerotic lesions: reversal by adrenal transplantation
    Ronald J van der Sluis
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, P O Box 9502, 2300RA Leiden, The Netherlands
    Atherosclerosis 221:76-83. 2012
    ..05 vs ADX). In conclusion, our studies show that adrenal-derived steroids protect against the development of initial atherosclerotic lesions in LDL receptor knockout mice...
  31. doi request reprint Hypocholesterolemia, foam cell accumulation, but no atherosclerosis in mice lacking ABC-transporter A1 and scavenger receptor BI
    Ying Zhao
    Division of Biopharmaceutics, Leiden University, Leiden, The Netherlands
    Atherosclerosis 218:314-22. 2011
    ....
  32. ncbi request reprint Coexistence of foam cells and hypocholesterolemia in mice lacking the ABC transporters A1 and G1
    Ruud Out
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Leiden University, The Netherlands
    Circ Res 102:113-20. 2008
    ..In conclusion, even under hypocholesterolemic conditions macrophages can be converted into foam cells, and ABCA1 and ABCG1 play an essential role in the prevention of foam cell formation...
  33. pmc Leukocytosis and enhanced susceptibility to endotoxemia but not atherosclerosis in adrenalectomized APOE knockout mice
    Menno Hoekstra
    Division of Biopharmaceutics, Leiden Academic Centre for Drug Research, Leiden, The Netherlands
    PLoS ONE 8:e80441. 2013
    ..The adrenalectomy-associated rise in white blood cells, however, does not alter atherosclerotic lesion development probably due to the parallel decrease in plasma levels of pro-atherogenic lipoproteins. ..
  34. doi request reprint Elimination of macrophages drives LXR-induced regression both in initial and advanced stages of atherosclerotic lesion development
    Marco van der Stoep
    Division of Biopharmaceutics, Leiden Academic Centre for Drug Research, Gorlaeus Laboratories, P O Box 9502, 2300RA Leiden, The Netherlands Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Heidelberglaan 100, 3584CX Utrecht, The Netherlands Electronic address
    Biochem Pharmacol 86:1594-602. 2013
    ....
  35. doi request reprint Niacin reduces plasma CETP levels by diminishing liver macrophage content in CETP transgenic mice
    Zhaosha Li
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Leiden University, The Netherlands
    Biochem Pharmacol 84:821-9. 2012
    ....
  36. ncbi request reprint Regulation of cholesterol homeostasis in macrophages and consequences for atherosclerotic lesion development
    Marieke Pennings
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, P O Box 9502, 2300 RA Leiden, The Netherlands
    FEBS Lett 580:5588-96. 2006
    ..We propose that in addition to the generally accepted role of these ABC-transporters in the prevention of foam cell formation by induction of cholesterol efflux from macrophages, they also influence the macrophage endocytotic uptake...
  37. ncbi request reprint Adenovirus-mediated hepatic overexpression of scavenger receptor class B type I accelerates chylomicron metabolism in C57BL/6J mice
    Ruud Out
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, 2300 RA Leiden, The Netherlands
    J Lipid Res 46:1172-81. 2005
    ....
  38. doi request reprint Nuclear receptor atlas of female mouse liver parenchymal, endothelial, and Kupffer cells
    Zhaosha Li
    Division of Biopharmaceutics, Leiden Academic Centre for Drug Research, Leiden University, The Netherlands
    Physiol Genomics 45:268-75. 2013
    ..Our gene expression catalog suggests that orphan nuclear receptors such as COUP-TFII, EAR2, and TR4 may be of significant importance as novel targets for pharmaceutical interventions in liver...
  39. ncbi request reprint Role of the macrophage very-low-density lipoprotein receptor in atherosclerotic lesion development
    Miranda Van Eck
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands
    Atherosclerosis 183:230-7. 2005
    ..The very-low-density lipoprotein receptor (VLDLr) is highly expressed in macrophage-rich areas of atherosclerotic lesions. The exact role of the macrophage VLDLr in atherosclerotic lesion development, however, is presently unclear...
  40. ncbi request reprint Scavenger receptor BI and ATP-binding cassette transporter A1 in reverse cholesterol transport and atherosclerosis
    Miranda Van Eck
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, Leiden, The Netherlands
    Curr Opin Lipidol 16:307-15. 2005
    ..This review focuses on the role of SR-BI and ABCA1 in reverse cholesterol transport in the context of atherosclerotic lesion development...
  41. doi request reprint Deletion of the high-density lipoprotein receptor scavenger receptor BI in mice modulates thrombosis susceptibility and indirectly affects platelet function by elevation of plasma free cholesterol
    Suzanne J A Korporaal
    Leiden Amsterdam Center for Drug Research, Division of Biopharmaceutics, Gorlaeus Laboratories, Einsteinweg 55, 2333 CC, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 31:34-42. 2011
    ..In mice, SR-BI deficiency results in increased plasma HDL cholesterol levels and enhanced susceptibility to atherosclerosis. The aim of this study was to investigate the role of SR-BI deficiency on platelet function...
  42. ncbi request reprint Increased oxidative stress in scavenger receptor BI knockout mice with dysfunctional HDL
    Miranda Van Eck
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Leiden University, The Netherlands
    Arterioscler Thromb Vasc Biol 27:2413-9. 2007
    ..In the current study the effect of disruption of SR-BI, a prominent regulator of HDL metabolism, on the activity of the HDL-associated antioxidant enzymes PON1 and PAF-AH as well as in vivo oxidative stress were investigated...
  43. pmc Effects of pyrazole partial agonists on HCA(2) -mediated flushing and VLDL-triglyceride levels in mice
    Zhaosha Li
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Leiden, The Netherlands
    Br J Pharmacol 167:818-25. 2012
    ..In the current study, we evaluated two partial agonists for HCA(2) , LUF6281 and LUF6283, with respect to their anti-dyslipidaemic potential and cutaneous flushing effect...
  44. doi request reprint Genetic studies in mice and humans reveal new physiological roles for the high-density lipoprotein receptor scavenger receptor class B type I
    Menno Hoekstra
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden, The Netherlands
    Curr Opin Lipidol 23:127-32. 2012
    ..Here, we will discuss findings that highlight the recently established novel link between scavenger receptor BI and adrenal and platelet function...
  45. ncbi request reprint Cholesterol 7alpha-hydroxylase deficiency in mice on an APOE*3-Leiden background increases hepatic ABCA1 mRNA expression and HDL-cholesterol
    Sabine M Post
    TNO Quality of Life, Department of Biomedical Research, Gaubius Laboratory, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 26:2724-30. 2006
    ..We investigated the effect of Cyp7a1 deficiency on HDL metabolism in APOE*3-Leiden transgenic mice...
  46. ncbi request reprint Scavenger receptors: friend or foe in atherosclerosis?
    Theo J C Van Berkel
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, University of Leiden, Gorlaeus Laboratories, Leiden, The Netherlands
    Curr Opin Lipidol 16:525-35. 2005
    ..This review focuses on the role of scavenger receptors in the development of atherosclerotic lesions...
  47. pmc Haloperidol inhibits the development of atherosclerotic lesions in LDL receptor knockout mice
    Ronald J van der Sluis
    Division of Biopharmaceutics, Cluster of BioTherapeutics, Leiden Academic Centre for Drug Research, Gorlaeus Laboratories, Leiden, The Netherlands
    Br J Pharmacol 172:2397-405. 2015
    ..Here we evaluated the potential of the typical antipsychotic drug haloperidol to modulate the cholesterol efflux function of macrophages in vitro and their susceptibility to atherosclerosis in vivo...
  48. doi request reprint Prolactin receptor antagonism uncouples lipids from atherosclerosis susceptibility
    Ronald J van der Sluis
    Division of BiopharmaceuticsGorlaeus Laboratories, Leiden Academic Centre for Drug Research, Einsteinweg 55, 2333CC Leiden, The NetherlandsLaboratory for Microbiology and Infection ControlAmphia Hospital, Breda, The NetherlandsDepartment EndocrinologyDiabetology and Metabolic Diseases, Antwerp University Hospital, Antwerp, BelgiumInsermUnit 1151, Prolactin Growth Hormone Pathophysiology Laboratory, Faculty of Medicine, Institut Necker Enfants malades INEM, University Paris Descartes, Sorbonne Paris Cité, Paris, France
    J Endocrinol 222:341-50. 2014
    ....
  49. doi request reprint Adrenocortical LDL receptor function negatively influences glucocorticoid output
    Ronald J van der Sluis
    Division of BiopharmaceuticsCluster BioTherapeutics, Gorlaeus Laboratories, Leiden Academic Centre for Drug Research, Einsteinweg 55, 2333 CC Leiden, The Netherlands
    J Endocrinol 226:145-54. 2015
    ..In conclusion, our studies in a mouse model with a human-like lipoprotein profile provide the first in vivo evidence for a novel inhibitory role of the LDLR in the control of adrenal glucocorticoid production. ..
  50. doi request reprint Plasma cholesteryl ester transfer protein is predominantly derived from Kupffer cells
    Yanan Wang
    Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
    Hepatology 62:1710-22. 2015
    ..Also, lipid-lowering drugs fenofibrate and niacin reduced liver KC content, accompanied by reduced plasma CETP concentration...
  51. ncbi request reprint Fenofibrate increases HDL-cholesterol by reducing cholesteryl ester transfer protein expression
    Caroline C van der Hoogt
    Netherlands Organization for Applied Scientific Research Quality of Life, Gaubius Laboratory, 2301 CE Leiden, The Netherlands
    J Lipid Res 48:1763-71. 2007
    ..01). We conclude that fenofibrate increases HDL-cholesterol by reducing the CETP-dependent transfer of cholesterol from HDL to (V)LDL, as related to lower hepatic CETP expression and a reduced plasma (V)LDL pool...
  52. ncbi request reprint Atorvastatin increases HDL cholesterol by reducing CETP expression in cholesterol-fed APOE*3-Leiden.CETP mice
    Willeke de Haan
    Netherlands Organization for Applied Scientific Research Quality of Life, Gaubius Laboratory, P O Box 2215, 2301 CE Leiden, The Netherlands
    Atherosclerosis 197:57-63. 2008
    ..Our aim was to determine whether the increase in HDL depends on CETP expression...