Diana C Grootendorst

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. doi Observational studies are complementary to randomized controlled trials
    Diana C Grootendorst
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Nephron Clin Pract 114:c173-7. 2010
  2. doi Screening: why, when, and how
    Diana C Grootendorst
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Kidney Int 76:694-9. 2009
  3. ncbi Excellent agreement between C-reactive protein measurement methods in end-stage renal disease patients--no additional power for mortality prediction with high-sensitivity CRP
    Diana C Grootendorst
    Leiden University Medical Center, Department of Clinical Epidemiology C9 29, P O Box 9600 2300 RC Leiden, The Netherlands
    Nephrol Dial Transplant 22:3277-84. 2007
  4. pmc Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD
    Diana C Grootendorst
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    Thorax 62:1081-7. 2007
  5. ncbi Mechanisms of bronchial hyperreactivity in asthma and chronic obstructive pulmonary disease
    Diana C Grootendorst
    Leiden University Medical Centre, Department of Pulmonology C3 P, P O Box 9600, 2300 RC Leiden, The Netherlands
    Proc Am Thorac Soc 1:77-87. 2004
  6. ncbi Efficacy of the novel phosphodiesterase-4 inhibitor BAY 19-8004 on lung function and airway inflammation in asthma and chronic obstructive pulmonary disease (COPD)
    D C Grootendorst
    Department of Pulmonology, Leiden University Medical Centre, Leiden, The Netherlands
    Pulm Pharmacol Ther 16:341-7. 2003
  7. ncbi Selective phosphodiesterase inhibitors for the treatment of asthma and chronic obstructive pulmonary disease
    Diana C Grootendorst
    Department of Pulmonology C2 P, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Curr Opin Allergy Clin Immunol 2:61-7. 2002
  8. ncbi Does a single dose of the phosphodiesterase 4 inhibitor, cilomilast (15 mg), induce bronchodilation in patients with chronic obstructive pulmonary disease?
    D C Grootendorst
    Department of Pulmonology, Leiden University Medical Centre, PO Box 9600, Leiden RC 2300, The Netherlands
    Pulm Pharmacol Ther 16:115-20. 2003
  9. doi Changes in parathyroid hormone, body mass index and the association with mortality in dialysis patients
    Christiane Drechsler
    Department of Clinical Epidemiology, LUMC, Leiden, The Netherlands
    Nephrol Dial Transplant 26:1340-6. 2011
  10. doi Association of blood pressure with the start of renal replacement therapy in elderly compared with young patients receiving predialysis care
    Moniek C M de Goeij
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Hypertens 25:1175-81. 2012

Collaborators

Detail Information

Publications32

  1. doi Observational studies are complementary to randomized controlled trials
    Diana C Grootendorst
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Nephron Clin Pract 114:c173-7. 2010
    ..Examples from the nephrology literature are used for illustration...
  2. doi Screening: why, when, and how
    Diana C Grootendorst
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Kidney Int 76:694-9. 2009
    ....
  3. ncbi Excellent agreement between C-reactive protein measurement methods in end-stage renal disease patients--no additional power for mortality prediction with high-sensitivity CRP
    Diana C Grootendorst
    Leiden University Medical Center, Department of Clinical Epidemiology C9 29, P O Box 9600 2300 RC Leiden, The Netherlands
    Nephrol Dial Transplant 22:3277-84. 2007
    ..The aim of this study was to determine agreement between imCRP and hsCRP in end-stage renal disease (ESRD) patients, and to examine whether the association between CRP and mortality is comparable when using imCRP or hsCRP...
  4. pmc Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD
    Diana C Grootendorst
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    Thorax 62:1081-7. 2007
    ..Results from in vitro studies with roflumilast indicate that it has anti-inflammatory properties that may be applicable for the treatment of COPD...
  5. ncbi Mechanisms of bronchial hyperreactivity in asthma and chronic obstructive pulmonary disease
    Diana C Grootendorst
    Leiden University Medical Centre, Department of Pulmonology C3 P, P O Box 9600, 2300 RC Leiden, The Netherlands
    Proc Am Thorac Soc 1:77-87. 2004
    ..The aim of this review is to present an overview of current knowledge of the mechanisms of bronchial hyperreactivity in asthma and COPD...
  6. ncbi Efficacy of the novel phosphodiesterase-4 inhibitor BAY 19-8004 on lung function and airway inflammation in asthma and chronic obstructive pulmonary disease (COPD)
    D C Grootendorst
    Department of Pulmonology, Leiden University Medical Centre, Leiden, The Netherlands
    Pulm Pharmacol Ther 16:341-7. 2003
    ..However, such treatment does seem to reduce levels of albumin and eosinophil cationic protein in sputum samples obtained from patients with COPD...
  7. ncbi Selective phosphodiesterase inhibitors for the treatment of asthma and chronic obstructive pulmonary disease
    Diana C Grootendorst
    Department of Pulmonology C2 P, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Curr Opin Allergy Clin Immunol 2:61-7. 2002
    ..The aim of the present review is to discuss the results of recent clinical intervention studies with phosphodiesterase-4 inhibitors in patients with asthma or chronic obstructive pulmonary disease...
  8. ncbi Does a single dose of the phosphodiesterase 4 inhibitor, cilomilast (15 mg), induce bronchodilation in patients with chronic obstructive pulmonary disease?
    D C Grootendorst
    Department of Pulmonology, Leiden University Medical Centre, PO Box 9600, Leiden RC 2300, The Netherlands
    Pulm Pharmacol Ther 16:115-20. 2003
    ..Our results implicate that the change in lung function seen after long-term treatment with cilomilast is not the result of acute bronchodilation in patients with COPD...
  9. doi Changes in parathyroid hormone, body mass index and the association with mortality in dialysis patients
    Christiane Drechsler
    Department of Clinical Epidemiology, LUMC, Leiden, The Netherlands
    Nephrol Dial Transplant 26:1340-6. 2011
    ..Obesity is associated with secondary hyperparathyroidism in the general population. It is unknown whether body mass index (BMI) affects parathyroid hormone (PTH) level and its association with mortality in dialysis patients...
  10. doi Association of blood pressure with the start of renal replacement therapy in elderly compared with young patients receiving predialysis care
    Moniek C M de Goeij
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Hypertens 25:1175-81. 2012
    ..Therefore, we investigated the association of systolic (SBP) and diastolic blood pressure (DBP) with the start of renal replacement therapy (RRT), in elderly (≥65 years) compared with young (<65 years) predialysis patients...
  11. doi Proteinuria as a risk marker for the progression of chronic kidney disease in patients on predialysis care and the role of angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker treatment
    Moniek C M de Goeij
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Nephron Clin Pract 121:c73-82. 2012
    ..Therefore, we investigated the association of urinary protein excretion (UPE) and ACEi/ARB treatment with renal function decline (RFD) and/or the start of renal replacement therapy (RRT) in patients on predialysis care...
  12. doi Association between serum albumin and mortality in dialysis patients is partly explained by inflammation, and not by malnutrition
    Renée de Mutsert
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    J Ren Nutr 19:127-35. 2009
    ..We investigated the effects of inflammatory and nutritional status on the association between serum albumin and mortality in hemodialysis (HD) and peritoneal dialysis (PD) patients...
  13. doi Association of body mass index with decline in residual kidney function after initiation of dialysis
    Christiane Drechsler
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Kidney Dis 53:1014-23. 2009
    ..Our aim was to study the effects of body mass index (BMI) on decline in kidney function and risk to develop anuria after initiation of dialysis therapy...
  14. doi Is the decline of renal function different before and after the start of dialysis?
    Dinanda J de Jager
    Department of Clinical Epidemiology, Leiden University MedicalCentre, Leiden, The Netherlands
    Nephrol Dial Transplant 28:698-705. 2013
    ..This study explores the time course of the glomerular filtration rate (GFR) between 1 year before and 1 year after the start of haemodialysis (HD) and peritoneal dialysis (PD)...
  15. doi Association between time of referral and survival in the first year of dialysis in diabetics and the elderly
    Dinanda J de Jager
    Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
    Nephrol Dial Transplant 26:652-8. 2011
    ..The objective of the study was to estimate the association between time of referral and survival during dialysis in diabetics and patients aged≥70 years...
  16. doi Subjective global assessment of nutritional status is strongly associated with mortality in chronic dialysis patients
    Renée de Mutsert
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Clin Nutr 89:787-93. 2009
    ..The subjective global assessment of nutritional status (SGA) is used to assess the nutritional status of chronic dialysis patients, but longitudinal data in relation to mortality risk are lacking...
  17. ncbi Excess mortality due to interaction between protein-energy wasting, inflammation and cardiovascular disease in chronic dialysis patients
    Renée de Mutsert
    Leiden University Medical Centre, Clinical Epidemiology, C9 P, PO Box 9600, 2300 RC Leiden, The Netherlands
    Nephrol Dial Transplant 23:2957-64. 2008
    ..Our aim was to examine the presence of additive interaction between these three risk factors in their association with long-term mortality in dialysis patients...
  18. ncbi Antiinflammatory effects of the phosphodiesterase-4 inhibitor cilomilast (Ariflo) in chronic obstructive pulmonary disease
    Elizabeth Gamble
    Department of Pulmonology, Leiden University Medical Centre, Leiden, The Netherlands
    Am J Respir Crit Care Med 168:976-82. 2003
    ..Phosphodiesterase-4 inhibitors represent a promising new class of substances for use in antiinflammatory treatment of this disease...
  19. pmc Survival in dialysis patients is not different between patients with diabetes as primary renal disease and patients with diabetes as a co-morbid condition
    Marielle A Schroijen
    Department of Clinical Epidemiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    BMC Nephrol 12:69. 2011
    ..We hypothesized that patients with diabetes as primary renal disease have worse survival compared to patients with diabetes as a co-morbid condition and aimed to compare all-cause mortality between these patient groups...
  20. pmc Association of blood pressure with decline in renal function and time until the start of renal replacement therapy in pre-dialysis patients: a cohort study
    Moniek C M de Goeij
    Department of Clinical Epidemiology, Leiden University Medical Center, Albinusdreef 2, Leiden, The Netherlands
    BMC Nephrol 12:38. 2011
    ....
  21. doi Agreement between different parameters of dialysis dose in achieving treatment targets: results from the NECOSAD study
    Karin E Moret
    Department of Internal Medicine, Maxima Medical Centre, Veldhoven, Leiden, The Netherlands
    Nephrol Dial Transplant 27:1145-52. 2012
    ....
  22. doi Cardiovascular and noncardiovascular mortality among patients starting dialysis
    Dinanda J de Jager
    Department of Clinical Epidemiology, Leiden University Medical Center, C7 104, PO Box 9600, 2300 RC Leiden, The Netherlands
    JAMA 302:1782-9. 2009
    ..Cardiovascular mortality is considered the main cause of death in patients receiving dialysis and is 10 to 20 times higher in such patients than in the general population...
  23. doi Patients' representations of their end-stage renal disease: relation with mortality
    Sandra van Dijk
    Department of Medical Psychology, Leiden University Medical Center, Leiden, The Netherlands
    Nephrol Dial Transplant 24:3183-5. 2009
    ..g. via adherence to treatment). Following these assumptions, we explored whether illness perceptions of ESRD-patients are related to mortality rates...
  24. doi The analysis of competing events like cause-specific mortality--beware of the Kaplan-Meier method
    Marion Verduijn
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Nephrol Dial Transplant 26:56-61. 2011
    ....
  25. doi Is obesity associated with a survival advantage in patients starting peritoneal dialysis?
    Renée de Mutsert
    Leiden University Medical Center, Department of Clinical Epidemiology, C7 P, Leiden, The Netherlands
    Contrib Nephrol 163:124-31. 2009
    ....
  26. ncbi Haemoglobin levels and health-related quality of life in young and elderly patients on specialized predialysis care
    Moniek C M de Goeij
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Zuid Holland, The Netherlands
    Nephrol Dial Transplant 29:1391-8. 2014
    ..Moreover, these effects may be different in specific subgroups (e.g. young versus elderly)...
  27. ncbi High plasma phosphate as a risk factor for decline in renal function and mortality in pre-dialysis patients
    Nora Voormolen
    Department of Clinical Radiology, Leiden University Medical Center, Albinusdreef 2, 2300 RC Leiden, The Netherlands
    Nephrol Dial Transplant 22:2909-16. 2007
    ..The aim of this study was to determine the association of plasma phosphate with renal function loss and mortality in CKD stage IV-V pre-dialysis patients with GFR <20 ml/min/1.73 m(2)...
  28. ncbi Validated safety predictions of airway responses to house dust mite in asthma
    A J Ravensberg
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    Clin Exp Allergy 37:100-7. 2007
    ..This can be accomplished by using the degree of non-specific airway responsiveness and skin sensitivity to allergen...
  29. pmc Chronic kidney disease in patients with diabetes mellitus type 2 or hypertension in general practice
    Victor van der Meer
    Department of Public Health and Primary Care, Leiden University Medical Centre and Academic Primary Health Care Centre Stevenshof, Leiden, The Netherlands
    Br J Gen Pract 60:884-90. 2010
    ..The prevalence and severity of chronic kidney disease (CKD) in primary care patients with diabetes or hypertension is unknown...
  30. ncbi Chronic sinusitis in severe asthma is related to sputum eosinophilia
    Anneke ten Brinke
    Department of Pulmonary Diseases, Leiden University Medical Center, Leiden, The Netherlands
    J Allergy Clin Immunol 109:621-6. 2002
    ..We hypothesized that the extent of inflammation in the nasal mucosa is related to lung function and inflammation in the bronchial mucosa in patients with severe asthma...
  31. pmc Association between CNDP1 genotype and diabetic nephropathy is sex specific
    Antien L Mooyaart
    Pathology, Leiden University Medical Center, Leiden, The Netherlands
    Diabetes 59:1555-9. 2010
    ..The 5-5 homozygous CNDP1 (carnosinase) genotype is associated with a reduced risk of diabetic nephropathy. We investigated whether this association is sex specific and independent of susceptibility for type 2 diabetes...
  32. pmc Screening strategies for chronic kidney disease in the general population: follow-up of cross sectional health survey
    Stein I Hallan
    Department of Cancer Research and Molecular Biology, Faculty of Medicine, Norwegian University of Science and Technology, 7006 Trondheim, Norway
    BMJ 333:1047. 2006
    ..To find an effective screening strategy for detecting patients with chronic kidney disease and to describe the natural course of the disease...