Friedo W Dekker

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. pmc Soluble Klotho is not independently associated with cardiovascular disease in a population of dialysis patients
    Maurits S Buiten
    Department of Nephrology, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    BMC Nephrol 15:197. 2014
  2. pmc Uric acid: association with rate of renal function decline and time until start of dialysis in incident pre-dialysis patients
    Hakan Nacak
    Department of Clinical Epidemiology, Leiden University Medical Center, Albinusdreef 2, Leiden 2333 ZA, The Netherlands
    BMC Nephrol 15:91. 2014
  3. pmc Pre-dialysis patients' perceived autonomy, self-esteem and labor participation: associations with illness perceptions and treatment perceptions. A cross-sectional study
    Daphne L Jansen
    NIVEL, Netherlands Institute for Health Services Research, 3500 BN Utrecht, The Netherlands
    BMC Nephrol 11:35. 2010
  4. pmc Interactive seminars or small group tutorials in preclinical medical education: results of a randomized controlled trial
    Zuzana de Jong
    Department of Rheumatology, Leiden University Medical Center, The Netherlands
    BMC Med Educ 10:79. 2010
  5. doi request reprint Survival analysis: time-dependent effects and time-varying risk factors
    Friedo W Dekker
    Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
    Kidney Int 74:994-7. 2008
  6. doi request reprint Disordered mineral metabolism is not a risk factor for loss of residual renal function in dialysis patients
    Marlies Noordzij
    Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DD Amsterdam, The Netherlands
    Nephrol Dial Transplant 24:1580-7. 2009
  7. doi request reprint Changes in parathyroid hormone, body mass index and the association with mortality in dialysis patients
    Christiane Drechsler
    Department of Clinical Epidemiology, LUMC, Leiden, The Netherlands
    Nephrol Dial Transplant 26:1340-6. 2011
  8. doi request reprint Bone alkaline phosphatase and mortality in dialysis patients
    Christiane Drechsler
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Clin J Am Soc Nephrol 6:1752-9. 2011
  9. doi request reprint Association of body mass index with decline in residual kidney function after initiation of dialysis
    Christiane Drechsler
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Kidney Dis 53:1014-23. 2009
  10. doi request reprint Trimestral variations of C-reactive protein, interleukin-6 and tumour necrosis factor-α are similarly associated with survival in haemodialysis patients
    Christiaan L Meuwese
    Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
    Nephrol Dial Transplant 26:1313-8. 2011

Detail Information

Publications110 found, 100 shown here

  1. pmc Soluble Klotho is not independently associated with cardiovascular disease in a population of dialysis patients
    Maurits S Buiten
    Department of Nephrology, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    BMC Nephrol 15:197. 2014
    ..The purpose of the present study was to determine the relationship between serum Klotho (sKlotho) and the presence of CVD in dialysis patients...
  2. pmc Uric acid: association with rate of renal function decline and time until start of dialysis in incident pre-dialysis patients
    Hakan Nacak
    Department of Clinical Epidemiology, Leiden University Medical Center, Albinusdreef 2, Leiden 2333 ZA, The Netherlands
    BMC Nephrol 15:91. 2014
    ..Therefore, we studied the association between baseline uric acid (UA) levels and the rate of decline in renal function and time until start of dialysis in pre-dialysis patients...
  3. pmc Pre-dialysis patients' perceived autonomy, self-esteem and labor participation: associations with illness perceptions and treatment perceptions. A cross-sectional study
    Daphne L Jansen
    NIVEL, Netherlands Institute for Health Services Research, 3500 BN Utrecht, The Netherlands
    BMC Nephrol 11:35. 2010
    ....
  4. pmc Interactive seminars or small group tutorials in preclinical medical education: results of a randomized controlled trial
    Zuzana de Jong
    Department of Rheumatology, Leiden University Medical Center, The Netherlands
    BMC Med Educ 10:79. 2010
    ..This study examines the educational effectiveness of small group tutorials and interactive seminars and students' preferences for and satisfaction with these formats...
  5. doi request reprint Survival analysis: time-dependent effects and time-varying risk factors
    Friedo W Dekker
    Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
    Kidney Int 74:994-7. 2008
    ..It will be shown that using time-dependent risk factors usually implies focusing on short-term effects only...
  6. doi request reprint Disordered mineral metabolism is not a risk factor for loss of residual renal function in dialysis patients
    Marlies Noordzij
    Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DD Amsterdam, The Netherlands
    Nephrol Dial Transplant 24:1580-7. 2009
    ..We examined associations between parameters of mineral metabolism and loss of residual renal function (RRF) in dialysis patients...
  7. doi request reprint Changes in parathyroid hormone, body mass index and the association with mortality in dialysis patients
    Christiane Drechsler
    Department of Clinical Epidemiology, LUMC, Leiden, The Netherlands
    Nephrol Dial Transplant 26:1340-6. 2011
    ..Obesity is associated with secondary hyperparathyroidism in the general population. It is unknown whether body mass index (BMI) affects parathyroid hormone (PTH) level and its association with mortality in dialysis patients...
  8. doi request reprint Bone alkaline phosphatase and mortality in dialysis patients
    Christiane Drechsler
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Clin J Am Soc Nephrol 6:1752-9. 2011
    ..The aim of this study was to assess the effect of bone-specific AP (BAP) on morbidity and mortality in dialysis patients...
  9. doi request reprint Association of body mass index with decline in residual kidney function after initiation of dialysis
    Christiane Drechsler
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Kidney Dis 53:1014-23. 2009
    ..Our aim was to study the effects of body mass index (BMI) on decline in kidney function and risk to develop anuria after initiation of dialysis therapy...
  10. doi request reprint Trimestral variations of C-reactive protein, interleukin-6 and tumour necrosis factor-α are similarly associated with survival in haemodialysis patients
    Christiaan L Meuwese
    Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
    Nephrol Dial Transplant 26:1313-8. 2011
    ..We therefore studied survival in relation to trimestral variations of CRP, interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α)...
  11. doi request reprint Proteinuria as a risk marker for the progression of chronic kidney disease in patients on predialysis care and the role of angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker treatment
    Moniek C M de Goeij
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Nephron Clin Pract 121:c73-82. 2012
    ..Therefore, we investigated the association of urinary protein excretion (UPE) and ACEi/ARB treatment with renal function decline (RFD) and/or the start of renal replacement therapy (RRT) in patients on predialysis care...
  12. doi request reprint Association of blood pressure with the start of renal replacement therapy in elderly compared with young patients receiving predialysis care
    Moniek C M de Goeij
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Hypertens 25:1175-81. 2012
    ..Therefore, we investigated the association of systolic (SBP) and diastolic blood pressure (DBP) with the start of renal replacement therapy (RRT), in elderly (≥65 years) compared with young (<65 years) predialysis patients...
  13. ncbi request reprint The 23K variant of the R23K polymorphism in the glucocorticoid receptor gene protects against postnatal growth failure and insulin resistance after preterm birth
    Martijn J J Finken
    Department of Pediatrics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Endocrinol Metab 92:4777-82. 2007
    ..Preterm birth is associated with postnatal growth failure, abdominal fat accumulation, insulin resistance, and hypertension, resembling increased glucocorticoid bioactivity...
  14. doi request reprint Short-term versus long-term effects of depressive symptoms on mortality in patients on dialysis
    Sandra van Dijk
    Department of Nephrology, Public Health and Primary Care, Leiden University Medical Center, The Netherlands
    Psychosom Med 74:854-60. 2012
    ..Depressive symptoms seem to pose a risk factor for mortality among patients on dialysis. It is currently unknown whether the association is only short-lived and whether associations over time depend on specific causes of mortality...
  15. doi request reprint Association between time of referral and survival in the first year of dialysis in diabetics and the elderly
    Dinanda J de Jager
    Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
    Nephrol Dial Transplant 26:652-8. 2011
    ..The objective of the study was to estimate the association between time of referral and survival during dialysis in diabetics and patients aged≥70 years...
  16. pmc Differences in progression to ESRD between black and white patients receiving predialysis care in a universal health care system
    Tessa O van den Beukel
    Department of Clinical Epidemiology, Leiden University Medical Center, The Netherlands
    Clin J Am Soc Nephrol 8:1540-7. 2013
    ..Possible explanations are differences in health care system factors. This study investigated whether progression is also faster in a universal health care system, where all patients receive comparable care...
  17. doi request reprint How baseline, new-onset, and persistent depressive symptoms are associated with cardiovascular and non-cardiovascular mortality in incident patients on chronic dialysis
    Sandra van Dijk
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    J Psychosom Res 74:511-7. 2013
    ..Depressive symptoms are associated with mortality among patients on chronic dialysis therapy. It is currently unknown how different courses of depressive symptoms are associated with both cardiovascular and non-cardiovascular mortality...
  18. pmc Survival in dialysis patients is not different between patients with diabetes as primary renal disease and patients with diabetes as a co-morbid condition
    Marielle A Schroijen
    Department of Clinical Epidemiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    BMC Nephrol 12:69. 2011
    ..We hypothesized that patients with diabetes as primary renal disease have worse survival compared to patients with diabetes as a co-morbid condition and aimed to compare all-cause mortality between these patient groups...
  19. doi request reprint Association between serum albumin and mortality in dialysis patients is partly explained by inflammation, and not by malnutrition
    Renée de Mutsert
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    J Ren Nutr 19:127-35. 2009
    ..We investigated the effects of inflammatory and nutritional status on the association between serum albumin and mortality in hemodialysis (HD) and peritoneal dialysis (PD) patients...
  20. doi request reprint Haemodialysis catheters increase mortality as compared to arteriovenous accesses especially in elderly patients
    Gürbey Ocak
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Nephrol Dial Transplant 26:2611-7. 2011
    ..However, differences in the all-cause and cause-specific mortality risk between catheter use and arteriovenous access use in young and elderly haemodialysis patients have not yet been investigated...
  21. doi request reprint Association between a self-rated health question and mortality in young and old dialysis patients: a cohort study
    Melissa S Y Thong
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Kidney Dis 52:111-7. 2008
    ..We assessed whether an SRH item predicts mortality in a large sample of incident dialysis patients beyond sociodemographic, disease, and clinical measures and possible age interaction...
  22. doi request reprint Subjective global assessment of nutritional status is strongly associated with mortality in chronic dialysis patients
    Renée de Mutsert
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Clin Nutr 89:787-93. 2009
    ..The subjective global assessment of nutritional status (SGA) is used to assess the nutritional status of chronic dialysis patients, but longitudinal data in relation to mortality risk are lacking...
  23. ncbi request reprint Disturbed mineral metabolism is associated with muscle and skin complaints in a prospective cohort of dialysis patients
    Marlies Noordzij
    Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Centre, University of Amsterdam, P O Box 22700, 1100 DE Amsterdam, The Netherlands
    Nephrol Dial Transplant 22:2944-9. 2007
    ....
  24. doi request reprint Is the decline of renal function different before and after the start of dialysis?
    Dinanda J de Jager
    Department of Clinical Epidemiology, Leiden University MedicalCentre, Leiden, The Netherlands
    Nephrol Dial Transplant 28:698-705. 2013
    ..This study explores the time course of the glomerular filtration rate (GFR) between 1 year before and 1 year after the start of haemodialysis (HD) and peritoneal dialysis (PD)...
  25. doi request reprint Is obesity associated with a survival advantage in patients starting peritoneal dialysis?
    Renée de Mutsert
    Leiden University Medical Center, Department of Clinical Epidemiology, C7 P, Leiden, The Netherlands
    Contrib Nephrol 163:124-31. 2009
    ....
  26. doi request reprint Nonthyroidal illness: a risk factor for coronary calcification and arterial stiffness in patients undergoing peritoneal dialysis?
    Christiaan L Meuwese
    Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands Baxter Novum, CLINTEC, Karolinska Institutet, Stockholm, Sweden
    J Intern Med 274:584-93. 2013
    ..We hypothesized that increased vascular calcification may mediate this relationship...
  27. doi request reprint Excess mortality due to interaction between protein-energy wasting, inflammation and cardiovascular disease in chronic dialysis patients
    Renée de Mutsert
    Leiden University Medical Centre, Clinical Epidemiology, C9 P, PO Box 9600, 2300 RC Leiden, The Netherlands
    Nephrol Dial Transplant 23:2957-64. 2008
    ..Our aim was to examine the presence of additive interaction between these three risk factors in their association with long-term mortality in dialysis patients...
  28. doi request reprint The role of psychosocial factors in ethnic differences in survival on dialysis in the Netherlands
    Tessa O van den Beukel
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Nephrol Dial Transplant 27:2472-9. 2012
    ..The reasons for this finding are not fully understood and European studies are scarce. This study examined whether ethnic differences in survival could be explained by patient characteristics, including psychosocial factors...
  29. pmc Type of arteriovenous vascular access and association with patency and mortality
    Gürbey Ocak
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    BMC Nephrol 14:79. 2013
    ..The aim of this study was to investigate risk factors for patency loss and to investigate the association between graft versus fistula use and outcomes (patency loss and mortality)...
  30. pmc The diagnostic work up of growth failure in secondary health care; an evaluation of consensus guidelines
    Floor K Grote
    Dept of Paediatrics, Leiden University Medical Center, Leiden, The Netherlands
    BMC Pediatr 8:21. 2008
    ..In the present paper we evaluate the diagnostic work-up in secondary health care according to existing consensus guidelines and study the frequency of underlying medical disorders...
  31. ncbi request reprint The Kidney Disease Outcomes Quality Initiative (K/DOQI) Guideline for Bone Metabolism and Disease in CKD: association with mortality in dialysis patients
    Marlies Noordzij
    Department of Clinical Epidemiology, Academic Medical Center, University of Amsterdam, The Netherlands
    Am J Kidney Dis 46:925-32. 2005
    ..Within the context of this guideline, we explored associations of these plasma concentrations with all-cause mortality risk in incident dialysis patients in The Netherlands...
  32. ncbi request reprint High plasma phosphate as a risk factor for decline in renal function and mortality in pre-dialysis patients
    Nora Voormolen
    Department of Clinical Radiology, Leiden University Medical Center, Albinusdreef 2, 2300 RC Leiden, The Netherlands
    Nephrol Dial Transplant 22:2909-16. 2007
    ..The aim of this study was to determine the association of plasma phosphate with renal function loss and mortality in CKD stage IV-V pre-dialysis patients with GFR <20 ml/min/1.73 m(2)...
  33. doi request reprint Symptom clusters in incident dialysis patients: associations with clinical variables and quality of life
    Melissa S Y Thong
    Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
    Nephrol Dial Transplant 24:225-30. 2009
    ..We aimed to identify symptom clusters in incident dialysis patients, and investigated associations between symptom clusters, clinical variables, functional status as measured by the Karnofsky Index and quality of life...
  34. pmc Baseline levels and trimestral variation of triiodothyronine and thyroxine and their association with mortality in maintenance hemodialysis patients
    Christiaan L Meuwese
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Clin J Am Soc Nephrol 7:131-8. 2012
    ..This study assesses the association between basal and trimestral variation of thyroid stimulating hormone, triiodothyronine, and thyroxine and mortality...
  35. doi request reprint Vitamin D status and clinical outcomes in incident dialysis patients: results from the NECOSAD study
    Christiane Drechsler
    1Department of Clinical Epidemiology Leiden University Medical Center, Leiden, The Netherlands
    Nephrol Dial Transplant 26:1024-32. 2011
    ..We aimed to elucidate whether European dialysis patients with low 25-hydroxyvitamin D (25(OH)D) levels are at increased risk of mortality and specific fatal events...
  36. doi request reprint Full loss of residual renal function causes higher mortality in dialysis patients; findings from a marginal structural model
    Willem M van der Wal
    Department of Clinical Epidemiology, Biostatistics and Bioinformatics, University of Amsterdam, The Netherlands
    Nephrol Dial Transplant 26:2978-83. 2011
    ..Declining residual renal function, as indicated by the glomerular filtration rate (GFR), is associated with an increased mortality risk in patients with end-stage renal disease (ESRD) on dialysis...
  37. doi request reprint Patients' representations of their end-stage renal disease: relation with mortality
    Sandra van Dijk
    Department of Medical Psychology, Leiden University Medical Center, Leiden, The Netherlands
    Nephrol Dial Transplant 24:3183-5. 2009
    ..g. via adherence to treatment). Following these assumptions, we explored whether illness perceptions of ESRD-patients are related to mortality rates...
  38. doi request reprint Is fetuin-A a mortality risk factor in dialysis patients or a mere risk marker? A Mendelian randomization approach
    Marion Verduijn
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Nephrol Dial Transplant 26:239-45. 2011
    ....
  39. doi request reprint Sodium Restriction in Patients With CKD: A Randomized Controlled Trial of Self-management Support
    Yvette Meuleman
    Department of Health, Medical, and Neuropsychology, Institute of Psychology, Leiden University, Leiden, The Netherlands Department of Medical Psychology, Leiden University Medical Center, Leiden, The Netherlands Electronic address
    Am J Kidney Dis . 2016
    ..To evaluate the effectiveness and sustainability of self-managed sodium restriction in patients with chronic kidney disease...
  40. doi request reprint Erythropoiesis-stimulating agents and thrombotic events in dialysis patients
    Marit M Suttorp
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands Electronic address
    Thromb Res 134:1081-6. 2014
    ..The ESA-associated risk of venous thromboembolism (VTE) has not been studied in dialysis patients yet. We therefore aimed to determine the association between ESA use and dose with ischemic stroke, myocardial infarction (MI) and VTE...
  41. pmc Erythropoiesis-stimulating agent resistance and mortality in hemodialysis and peritoneal dialysis patients
    Marit M Suttorp
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    BMC Nephrol 14:200. 2013
    ..ESA resistance has been associated with mortality in hemodialysis (HD) patients, but in peritoneal dialysis (PD) patients data is limited. Therefore we assessed the relation between ESA resistance in both HD and PD patients...
  42. ncbi request reprint Association between body mass index and mortality is similar in the hemodialysis population and the general population at high age and equal duration of follow-up
    Renée de Mutsert
    Leiden University Medical Center, Department of Clinical Epidemiology, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Am Soc Nephrol 18:967-74. 2007
    ..The clinical implication of this study is that to improve survival in the hemodialysis population, more attention should be paid to patients who are underweight instead of overweight...
  43. pmc Association of blood pressure with decline in renal function and time until the start of renal replacement therapy in pre-dialysis patients: a cohort study
    Moniek C M de Goeij
    Department of Clinical Epidemiology, Leiden University Medical Center, Albinusdreef 2, Leiden, The Netherlands
    BMC Nephrol 12:38. 2011
    ....
  44. doi request reprint Cardiovascular and noncardiovascular mortality among patients starting dialysis
    Dinanda J de Jager
    Department of Clinical Epidemiology, Leiden University Medical Center, C7 104, PO Box 9600, 2300 RC Leiden, The Netherlands
    JAMA 302:1782-9. 2009
    ..Cardiovascular mortality is considered the main cause of death in patients receiving dialysis and is 10 to 20 times higher in such patients than in the general population...
  45. doi request reprint The -174G/C variant of IL6 as risk factor for mortality and technique failure in a large cohort of peritoneal dialysis patients
    Marion Verduijn
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Nephrol Dial Transplant 27:3516-23. 2012
    ..The aim of this study was to investigate this IL6 variant as risk factor for mortality and technique failure in a large cohort of Caucasian PD patients...
  46. ncbi request reprint Adjustment for comorbidity in studies on health status in ESRD patients: which comorbidity index to use?
    Jeannette G van Manen
    Department of Clinical Epidemiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Am Soc Nephrol 14:478-85. 2003
    ..The Khan, Davies, and the Charlson indices will adjust to the same extent for the potential confounding effect of comorbidity in studies with health status as an outcome. Separate comorbidity diagnoses will adjust best for comorbidity...
  47. ncbi request reprint Excellent agreement between C-reactive protein measurement methods in end-stage renal disease patients--no additional power for mortality prediction with high-sensitivity CRP
    Diana C Grootendorst
    Leiden University Medical Center, Department of Clinical Epidemiology C9 29, P O Box 9600 2300 RC Leiden, The Netherlands
    Nephrol Dial Transplant 22:3277-84. 2007
    ..The aim of this study was to determine agreement between imCRP and hsCRP in end-stage renal disease (ESRD) patients, and to examine whether the association between CRP and mortality is comparable when using imCRP or hsCRP...
  48. doi request reprint Progression of aortic calcification is associated with disorders of mineral metabolism and mortality in chronic dialysis patients
    Marlies Noordzij
    Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Nephrol Dial Transplant 26:1662-9. 2011
    ..In addition, we assessed the impact of aortic calcification on mortality...
  49. ncbi request reprint The effect of single and repeatedly high concentrations of C-reactive protein on cardiovascular and non-cardiovascular mortality in patients starting with dialysis
    Wendy P J den Elzen
    Department of Clinical Epidemiology, Leiden University Medical Centre, C9 P, PO Box 9600, 2300 RC Leiden, The Netherlands
    Nephrol Dial Transplant 21:1588-95. 2006
    ..However, CRP can be temporarily elevated due to infections. Therefore, we investigated the effect of single and repeatedly high concentrations of CRP on cardiovascular and non-cardiovascular mortality in incident dialysis patients...
  50. doi request reprint Growth-restricted preterm newborns are predisposed to functional adrenal hyperandrogenism in adult life
    Christiaan L Meuwese
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Endocrinol 163:681-9. 2010
    ..The long-term effects of perinatal growth and corticosteroid exposure on adrenal steroid concentrations in adults born very preterm are uncertain...
  51. doi request reprint Reporting of interaction
    Dinanda J de Jager
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Nephron Clin Pract 119:c158-61. 2011
    ....
  52. doi request reprint The analysis of competing events like cause-specific mortality--beware of the Kaplan-Meier method
    Marion Verduijn
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Nephrol Dial Transplant 26:56-61. 2011
    ....
  53. pmc Survival prognosis after the start of a renal replacement therapy in the Netherlands: a retrospective cohort study
    Aline C Hemke
    Organ Centre, Dutch Transplant Foundation, Leiden, The Netherlands
    BMC Nephrol 14:258. 2013
    ..The aim of this study was to develop a model that includes dialysis survival and survival after an eventual transplantation...
  54. doi request reprint The association between dialysis modality and the risk for dialysis technique and non-dialysis technique-related infections
    Anouk T N van Diepen
    Division of Nephrology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Nephrol Dial Transplant 29:2244-50. 2014
    ..Dialysis modality has been hypothesized to be a potential immunomodulatory factor. The objective of this study was to determine the influence of the first dialysis modality on the risk for infections on dialysis...
  55. pmc Candidate gene analysis of arteriovenous fistula failure in hemodialysis patients
    Jeffrey J W Verschuren
    Departments of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Clin J Am Soc Nephrol 8:1358-66. 2013
    ..The current objective was to investigate the association between AVF failure and single nucleotide polymorphisms (SNPs) in genes related to these pathophysiologic processes in a large population of incident hemodialysis patients...
  56. pmc Predicting mortality in patients with diabetes starting dialysis
    Merel van Diepen
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 9:e89744. 2014
    ..Therefore, the objective of this study was to identify predictors for 1-year mortality in diabetic dialysis patients and use these results to develop a prediction model...
  57. ncbi request reprint ACE I/D polymorphism is associated with mortality in a cohort study of patients starting with dialysis
    Femke van der Sman-de Beer
    Department of Clinical Epidemiology, Leiden University Medical Center, The Netherlands
    Kidney Int 68:2237-43. 2005
    ..In dialysis patients, only a few follow-up studies have addressed the relationship between the insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme (ACE) gene and mortality, but the available data are contradictory...
  58. doi request reprint Agreement between different parameters of dialysis dose in achieving treatment targets: results from the NECOSAD study
    Karin E Moret
    Department of Internal Medicine, Maxima Medical Centre, Veldhoven, Leiden, The Netherlands
    Nephrol Dial Transplant 27:1145-52. 2012
    ....
  59. doi request reprint Interaction on an additive scale
    Renée de Mutsert
    Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
    Nephron Clin Pract 119:c154-7. 2011
    ....
  60. doi request reprint A practical approach to Bland-Altman plots and variation coefficients for log transformed variables
    Anne M Euser
    Department of Clinical Epidemiology, Leiden University Medical Centre, The Netherlands
    J Clin Epidemiol 61:978-82. 2008
    ..Indicators of reproducibility for log-transformed variables can often not be calculated straightforwardly and are subsequently incorrectly interpreted...
  61. doi request reprint Differences in survival on chronic dialysis treatment between ethnic groups in Denmark: a population-wide, national cohort study
    Tessa O van den Beukel
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands Department of Nephrology, Sint Lucas Andreas Hospital, Amsterdam, The Netherlands
    Nephrol Dial Transplant 31:1160-7. 2016
    ....
  62. ncbi request reprint Pre-dialysis decline of measured glomerular filtration rate but not serum creatinine-based estimated glomerular filtration rate is a risk factor for mortality on dialysis
    Chava L Ramspek
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Nephrol Dial Transplant . 2016
    ....
  63. pmc Serum Cardiac Troponin-I is Superior to Troponin-T as a Marker for Left Ventricular Dysfunction in Clinically Stable Patients with End-Stage Renal Disease
    Maurits S Buiten
    Department of Cardiology, Leiden University Medical Center LUMC, Leiden, The Netherlands
    PLoS ONE 10:e0134245. 2015
    ..In dialysis patients however, serum cTnT levels are often elevated, unlike cTnI levels. The present study aims to elucidate the associations of cTnI and cTnT with CVD in clinically stable dialysis patients...
  64. doi request reprint Treatment with high dose of erythropoiesis-stimulating agents and mortality: analysis with a sequential Cox approach and a marginal structural model
    Marit M Suttorp
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Pharmacoepidemiol Drug Saf 24:1068-75. 2015
    ..However, no trial that directly compares treatment with different ESA doses has been published. We thus aimed to estimate the effect of high ESA dose on mortality in an observational cohort of dialysis patients...
  65. pmc Candidate Gene Analysis of Mortality in Dialysis Patients
    Tonia C Rothuizen
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 10:e0143079. 2015
    ..Dialysis patients have high cardiovascular mortality risk. This study aimed to investigate the association between SNPs of genes involved in vascular processes and mortality in dialysis patients...
  66. doi request reprint The effect of joint exposures: examining the presence of interaction
    Renée de Mutsert
    Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
    Kidney Int 75:677-81. 2009
    ....
  67. doi request reprint Venous and arterial thrombosis in dialysis patients
    Gürbey Ocak
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Thromb Haemost 106:1046-52. 2011
    ....
  68. ncbi request reprint Serum troponin T concentration as a predictor of mortality in hemodialysis and peritoneal dialysis patients
    Bas Havekes
    Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Am J Kidney Dis 47:823-9. 2006
    ..Although it is known that troponin T is an independent risk factor in dialysis patients as well, its prognostic value when measured routinely in clinical practice, particularly in addition to other risk indicators, is unclear...
  69. ncbi request reprint Reliability studies can be designed more efficiently by using variance components estimates from different sources
    Anne M Euser
    Department of Clinical Epidemiology, Leiden University Medical Center, Albinusdreef 2, P O Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Epidemiol 60:1010-4. 2007
    ..In this article, the advantages of combining data from the reliability study and the large study to improve the estimation of intra-class correlation coefficients (ICCs) are highlighted...
  70. ncbi request reprint Prospective study of the effect of blood pressure on renal function in old age: the Leiden 85-Plus Study
    Thomas van Bemmel
    Department of Gerontology and Geriatrics, C2 R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Am Soc Nephrol 17:2561-6. 2006
    ..08]; P < 0.001). In the oldest individual, high BP is not associated with renal function. In contrast, low DBP is associated with an accelerated decline of renal function. The clinical implications of these findings have to be studied...
  71. doi request reprint Genetic association studies: discovery of the genetic basis of renal disease
    Marion Verduijn
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Nephron Clin Pract 119:c236-9. 2011
    ..e. genome-wide association studies, aiming for the discovery of new genetic associations. This educational article is an introduction to genetic association studies for nephrologists and researchers in the domain of kidney disease...
  72. doi request reprint Variations in C-reactive protein during a single haemodialysis session do not associate with mortality
    Christiaan L Meuwese
    Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
    Nephrol Dial Transplant 25:3717-23. 2010
    ..An increase in C-reactive protein (CRP) levels during a single haemodialysis (HD) session has been associated with mortality. These associations, however, are difficult to understand from the current understanding of CRP metabolism...
  73. ncbi request reprint Social support predicts survival in dialysis patients
    Melissa S Y Thong
    Department of Clinical Epidemiology, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands
    Nephrol Dial Transplant 22:845-50. 2007
    ..In the area of renal diseases, this topic has not yet been studied extensively. This study, therefore, aimed to investigate the association between social support and survival for patients on dialysis...
  74. doi request reprint Monitoring of inflammation in patients on dialysis: forewarned is forearmed
    Christiaan L Meuwese
    Department of Clinical Epidemiology, Leiden University Medical Center, AZ Leiden, The Netherlands
    Nat Rev Nephrol 7:166-76. 2011
    ....
  75. doi request reprint Cohort studies: prospective versus retrospective
    Anne M Euser
    Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
    Nephron Clin Pract 113:c214-7. 2009
    ..If one is aware of this, cohort studies can form a potent study design in nephrology producing, in general, highly generalizable results...
  76. pmc Uric acid is not associated with decline in renal function or time to renal replacement therapy initiation in a referred cohort of patients with Stage III, IV and V chronic kidney disease
    Hakan Nacak
    The Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Nephrol Dial Transplant 30:2039-45. 2015
    ..The aim of this study was to investigate the association between baseline UA and renal outcomes in patients with established CKD (Stages III-V)...
  77. doi request reprint Graphical presentation of confounding in directed acyclic graphs
    Marit M Suttorp
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Nephrol Dial Transplant 30:1418-23. 2015
    ..Ultimately, these examples will show that DAGs can be preferable to the traditional methods to identify sources of confounding, especially in complex research questions. ..
  78. doi request reprint Haemoglobin levels and health-related quality of life in young and elderly patients on specialized predialysis care
    Moniek C M de Goeij
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Zuid Holland, The Netherlands
    Nephrol Dial Transplant 29:1391-8. 2014
    ..Moreover, these effects may be different in specific subgroups (e.g. young versus elderly)...
  79. pmc Single nucleotide variants in the protein C pathway and mortality in dialysis patients
    Gürbey Ocak
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 9:e97251. 2014
    ..We investigated whether common single nucleotide variants (SNV) in genes encoding protein C pathway components were associated with all-cause 5 years mortality risk in dialysis patients...
  80. doi request reprint Multiple imputation: dealing with missing data
    Moniek C M de Goeij
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Nephrol Dial Transplant 28:2415-20. 2013
    ..However, the method of multiple imputation has scarcely been used in medical literature. We, therefore, encourage authors to do so in the future when possible...
  81. pmc Course of symptoms and health-related quality of life during specialized pre-dialysis care
    Moniek C M de Goeij
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 9:e93069. 2014
    ..The aims of our study were to describe the course of symptoms and HRQOL during pre-dialysis care and to investigate their association with poor health outcomes...
  82. pmc Effect of erythropoiesis-stimulating agents on blood pressure in pre-dialysis patients
    Marit M Suttorp
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 8:e84848. 2013
    ..One of the proposed mechanisms is the elevation of blood pressure (BP) by ESA. Therefore, we aimed to determine whether the use of ESA was associated with antihypertensive treatment and higher BP...
  83. doi request reprint IGF1 promoter polymorphism and cranial growth in individuals born very preterm
    Anne M Euser
    Department of Clinical Epidemiology, Leiden University Medical Center, The Netherlands
    Horm Res Paediatr 76:27-34. 2011
    ..Major defects in the IGF1 gene are associated with severely reduced cranial and linear growth. The association between IGF1 promoter polymorphisms and growth is uncertain...
  84. doi request reprint Matching, an appealing method to avoid confounding?
    Michiel A de Graaf
    Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands M A de_Graaf LUMC nl
    Nephron Clin Pract 118:c315-8. 2011
    ..A matched case-control study requires statistical analysis to correct for this phenomenon. Nonetheless, a matched case-control study is suitable for confounders that are difficult to measure...
  85. doi request reprint Causes of permanent childhood hearing impairment
    Anna M H Korver
    Willem Alexander Children and Youth Center, Subdepartment of Social Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Laryngoscope 121:409-16. 2011
    ..Interest in the causes of PCHI has grown recently due to increasing diagnostic possibilities. We investigated the evidence for the reported distribution of these causes...
  86. doi request reprint Observational studies are complementary to randomized controlled trials
    Diana C Grootendorst
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Nephron Clin Pract 114:c173-7. 2010
    ..Examples from the nephrology literature are used for illustration...
  87. doi request reprint Screening: why, when, and how
    Diana C Grootendorst
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Kidney Int 76:694-9. 2009
    ....
  88. ncbi request reprint Immunologic risk factors and glomerular C4d deposits in chronic transplant glomerulopathy
    Yvo W Sijpkens
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Kidney Int 65:2409-18. 2004
    ..We evaluated the epidemiologic, clinical, and histologic features of chronic transplant glomerulopathy. To determine the possible contribution of humoral immune responses, we assessed glomerular deposition of C4d...
  89. doi request reprint Gluten tolerance in adult patients with celiac disease 20 years after diagnosis?
    Erica G D Hopman
    Department of Dietetics and Nutrition, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Gastroenterol Hepatol 20:423-9. 2008
    ..A number of patients, however, discontinue the gluten-free diet (GFD) without developing symptoms or signs. The aim of our study was to investigate whether CD patients are capable of developing tolerance to gluten...
  90. ncbi request reprint Ethnic patterns of cytologic abnormalities in cervical smears in suriname, a high-risk area for cervical cancer
    Christine F W Vermeulen
    Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
    Acta Cytol 50:621-6. 2006
    ....
  91. ncbi request reprint The influence of COPD on health-related quality of life independent of the influence of comorbidity
    Jeannette G van Manen
    Department of General Practice, Division of Public Health, Academic Medical Center University of Amsterdam, P O Box 22660, 1100 DD, Amsterdam, The Netherlands
    J Clin Epidemiol 56:1177-84. 2003
    ..The goal of this study was to determine the influence of chronic obstructive pulmonary disease (COPD) on health-related quality of life (HRQL) independent of comorbidity...
  92. ncbi request reprint Determinants of survival in treated acromegaly in a single center: predictive value of serial insulin-like growth factor I measurements
    Nienke R Biermasz
    Department of Endocrinology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    J Clin Endocrinol Metab 89:2789-96. 2004
    ..Of the three remission criteria, IGF-I was the only one to be significantly associated with survival in this study, with a relative risk of 4.78 for an elevated as opposed to a normal IGF-I concentration...
  93. ncbi request reprint How to adjust for comorbidity in survival studies in ESRD patients: a comparison of different indices
    Jeannette G van Manen
    Department of Clinical Epidemiology, Dianet Dialysis Centres, University of Amsterdam, The Netherlands
    Am J Kidney Dis 40:82-9. 2002
    ..In addition, these three indices were compared with a new index that explicitly incorporates the severity grading of a number of comorbid diseases...
  94. ncbi request reprint Lipid profile and carotid intima-media thickness in a prospective cohort of very preterm subjects at age 19 years: effects of early growth and current body composition
    Martijn J J Finken
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Pediatr Res 59:604-9. 2006
    ..Attempts to reduce the CVD risk in this specific population should focus on weight reduction in young adulthood rather than on optimizing the early growth pattern...
  95. doi request reprint Mendelian randomization: use of genetics to enable causal inference in observational studies
    Marion Verduijn
    Department of Clinical Epidemiology, Leiden University Medical Center, P O Box 9600 2300 RC Leiden, The Netherlands
    Nephrol Dial Transplant 25:1394-8. 2010
    ..This educational article describes the approach of Mendelian randomization, its underlying rationale and its necessary assumptions...
  96. pmc Chronic kidney disease in patients with diabetes mellitus type 2 or hypertension in general practice
    Victor van der Meer
    Department of Public Health and Primary Care, Leiden University Medical Centre and Academic Primary Health Care Centre Stevenshof, Leiden, The Netherlands
    Br J Gen Pract 60:884-90. 2010
    ..The prevalence and severity of chronic kidney disease (CKD) in primary care patients with diabetes or hypertension is unknown...
  97. doi request reprint Incremental prognostic value of an abnormal baseline spatial QRS-T angle in chronic dialysis patients
    Mihaly K de Bie
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Europace 15:290-6. 2013
    ..The objective of this study was to establish the prognostic value of the spatial QRS-T angle...
  98. doi request reprint Behavioural research in patients with end-stage renal disease: a review and research agenda
    Ad A Kaptein
    Unit of Psychology, LUMC, Leiden, The Netherlands
    Patient Educ Couns 81:23-9. 2010
    ....
  99. ncbi request reprint Long-term height gain of prematurely born children with neonatal growth restraint: parallellism with the growth pattern of short children born small for gestational age
    Martijn J J Finken
    Department of Pediatrics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, Netherlands
    Pediatrics 118:640-3. 2006
    ....
  100. doi request reprint The apparent paradox of maternal seropositivity as a risk factor for congenital cytomegalovirus infection: a population-based prediction model
    Jutte J C de Vries
    Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands
    Rev Med Virol 23:241-9. 2013
    ..These results imply that prevention research such as vaccine and hygiene studies should not only be directed at seronegative but also seropositive pregnant women...