Wouter de Ruijter

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint [The guideline 'Cardiovascular risk management' is too simplified for elderly care]
    Wouter de Ruijter
    Leids Universitair Medisch Centrum, afd Public Health en Eerstelijnsgeneeskunde, Leiden, The Netherlands
    Ned Tijdschr Geneeskd 156:A5197. 2012
  2. ncbi request reprint The routine electrocardiogram for cardiovascular risk stratification in old age: the Leiden 85-plus study
    Wouter de Ruijter
    Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands
    J Am Geriatr Soc 55:872-7. 2007
  3. ncbi request reprint [Cardiovascular prevention in the over-80 age group is not beneficial]
    W de Ruijter
    Leids Universitair Medisch Centrum, afd Public Health en Eerstelijnsgeneeskunde, Postbus 9600, 2300 RC Leiden
    Ned Tijdschr Geneeskd 152:27. 2008
  4. pmc The additional value of routine electrocardiograms in cardiovascular risk management of older people
    Wouter de Ruijter
    Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands
    Scand J Prim Health Care 26:147-53. 2008
  5. pmc Use of Framingham risk score and new biomarkers to predict cardiovascular mortality in older people: population based observational cohort study
    Wouter de Ruijter
    Leiden University Medical Center, Department of Public Health and Primary Care V0 P, PO Box 9600, 2300 RC Leiden, Netherlands
    BMJ 338:a3083. 2009
  6. pmc Time trends in preventive drug treatment after myocardial infarction in older patients
    Wouter de Ruijter
    Leiden University Medical Center, Department of Public Health and Primary Care, Leiden, The Netherlands
    Br J Gen Pract 60:47-9. 2010
  7. pmc How learning style affects evidence-based medicine: a survey study
    Sandra E Zwolsman
    Department of General Practice Family Medicine, Academic Medical Center University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    BMC Med Educ 11:81. 2011
  8. pmc Homocysteine levels and treatment effect in the PROspective Study of Pravastatin in the Elderly at Risk
    Yvonne M Drewes
    Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands
    J Am Geriatr Soc 62:213-21. 2014
  9. doi request reprint Biological correlates of blood pressure variability in elderly at high risk of cardiovascular disease
    Rosalinde K E Poortvliet
    Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands
    Am J Hypertens 28:469-79. 2015
  10. doi request reprint Blood pressure trends and mortality: the Leiden 85-plus Study
    Rosalinde K E Poortvliet
    Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands
    J Hypertens 31:63-70. 2013

Collaborators

Detail Information

Publications38

  1. ncbi request reprint [The guideline 'Cardiovascular risk management' is too simplified for elderly care]
    Wouter de Ruijter
    Leids Universitair Medisch Centrum, afd Public Health en Eerstelijnsgeneeskunde, Leiden, The Netherlands
    Ned Tijdschr Geneeskd 156:A5197. 2012
    ..Alternative approaches are conveyed: the use of age-dependent thresholds for different risk categories, the use of relative risk charts, and the search for better risk markers in (very) old age...
  2. ncbi request reprint The routine electrocardiogram for cardiovascular risk stratification in old age: the Leiden 85-plus study
    Wouter de Ruijter
    Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands
    J Am Geriatr Soc 55:872-7. 2007
    ..To explore the prognostic value of signs of prior myocardial infarction (MI) and atrial fibrillation (AF) on routine electrocardiograms (ECGs) at the age of 85 with respect to mortality and changes in functional status...
  3. ncbi request reprint [Cardiovascular prevention in the over-80 age group is not beneficial]
    W de Ruijter
    Leids Universitair Medisch Centrum, afd Public Health en Eerstelijnsgeneeskunde, Postbus 9600, 2300 RC Leiden
    Ned Tijdschr Geneeskd 152:27. 2008
    ..However, evidence for the effectiveness of any preventive intervention is lacking. Regarding primary prevention, it is also unknown which elderly are actually at risk of developing new cardiovascular disease...
  4. pmc The additional value of routine electrocardiograms in cardiovascular risk management of older people
    Wouter de Ruijter
    Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands
    Scand J Prim Health Care 26:147-53. 2008
    ..To evaluate whether routinely performed ECGs in older people from the general population have added value for cardiovascular risk management beyond the information that is already available from their medical records...
  5. pmc Use of Framingham risk score and new biomarkers to predict cardiovascular mortality in older people: population based observational cohort study
    Wouter de Ruijter
    Leiden University Medical Center, Department of Public Health and Primary Care V0 P, PO Box 9600, 2300 RC Leiden, Netherlands
    BMJ 338:a3083. 2009
    ..To investigate the performance of classic risk factors, and of some new biomarkers, in predicting cardiovascular mortality in very old people from the general population with no history of cardiovascular disease...
  6. pmc Time trends in preventive drug treatment after myocardial infarction in older patients
    Wouter de Ruijter
    Leiden University Medical Center, Department of Public Health and Primary Care, Leiden, The Netherlands
    Br J Gen Pract 60:47-9. 2010
    ..Although the greatest relative increase (2.2 times greater) took place in patients aged > or =80 years, these patients consistently had most room for improvement...
  7. pmc How learning style affects evidence-based medicine: a survey study
    Sandra E Zwolsman
    Department of General Practice Family Medicine, Academic Medical Center University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    BMC Med Educ 11:81. 2011
    ..In order to tailor EBM education to the individual learner, this study aims to determine whether there is a relationship between an individual's learning style and EBM competence (knowledge/skills, attitude, behaviour)...
  8. pmc Homocysteine levels and treatment effect in the PROspective Study of Pravastatin in the Elderly at Risk
    Yvonne M Drewes
    Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands
    J Am Geriatr Soc 62:213-21. 2014
    ..To assess the effect of preventive pravastatin treatment on coronary heart disease (CHD) morbidity and mortality in older persons at risk for cardiovascular disease (CVD), stratified according to plasma levels of homocysteine...
  9. doi request reprint Biological correlates of blood pressure variability in elderly at high risk of cardiovascular disease
    Rosalinde K E Poortvliet
    Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands
    Am J Hypertens 28:469-79. 2015
    ..Visit-to-visit variability in blood pressure is an independent predictor of cardiovascular disease. This study investigates biological correlates of intra-individual variability in blood pressure in older persons...
  10. doi request reprint Blood pressure trends and mortality: the Leiden 85-plus Study
    Rosalinde K E Poortvliet
    Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands
    J Hypertens 31:63-70. 2013
    ..To evaluate the independent contributions of both the trend in SBP and the SBP value at age 90 to the prediction of mortality in nonagenarians...
  11. doi request reprint Risk stratification and treatment effect of statins in secondary cardiovascular prevention in old age: Additive value of N-terminal pro-B-type natriuretic peptide
    Rosalinde Ke Poortvliet
    Department of Public Health and Primary Care, Leiden University Medical Center, The Netherlands
    Eur J Prev Cardiol 23:1104-13. 2016
    ..Treatment effect of pravastatin was assessed across low and high risk groups identified by the best performing models...
  12. doi request reprint Low blood pressure predicts increased mortality in very old age even without heart failure: the Leiden 85-plus Study
    Rosalinde K E Poortvliet
    Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Heart Fail 15:528-33. 2013
    ....
  13. doi request reprint High blood pressure, physical and cognitive function, and risk of stroke in the oldest old: the Leiden 85-plus Study
    Behnam Sabayan
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Stroke 44:15-20. 2013
    ..Heterogeneity of the populations under study may underlie variation in outcomes. We examined whether the level of physical and cognitive function moderates the association between blood pressure and stroke...
  14. doi request reprint Validity of the three apathy items of the Geriatric Depression Scale (GDS-3A) in measuring apathy in older persons
    Anne Suzanne Bertens
    Department of Radiology, Leiden University Medical Centre, Leiden, The Netherlands
    Int J Geriatr Psychiatry . 2016
    ..We aimed to assess how accurately the GDS-3A discriminates between presence and absence of apathy in two populations of community-dwelling older persons, using the Apathy Scale as reference standard...
  15. doi request reprint Lower Blood Pressure Is Associated With Smaller Subcortical Brain Volumes in Older Persons
    Jessica C Foster-Dingley
    Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
    Am J Hypertens 28:1127-33. 2015
    ..The objective of this study was to investigate whether BP is associated with cortical and subcortical brain volumes in older old persons with mild cognitive deficits...
  16. doi request reprint Effect of Discontinuation of Antihypertensive Treatment in Elderly People on Cognitive Functioning--the DANTE Study Leiden: A Randomized Clinical Trial
    Justine E F Moonen
    Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
    JAMA Intern Med 175:1622-30. 2015
    ..Older persons are at risk for impaired cerebral autoregulation; lowering their BP may compromise cerebral blood flow and cognitive function...
  17. pmc NT-proBNP, blood pressure, and cognitive decline in the oldest old: The Leiden 85-plus Study
    Peter van Vliet
    From the Departments of Gerontology and Geriatrics P v V, B S, L W W, S P M, A J M d C, R G J W, Neurology P v V, Radiology B S, and Public Health and Primary Care R K E P, W d R, J G, Leiden University Medical Center and Netherlands Consortium of Healthy Ageing L W W, A J M d C, R G J W, Leiden, The Netherlands
    Neurology 83:1192-9. 2014
    ..To study the relation between N-terminal pro-brain natriuretic peptide (NT-proBNP) levels, used as a marker of heart failure in clinical practice, blood pressure (BP), and cognitive decline in the oldest old...
  18. doi request reprint N-terminal pro-brain natriuretic peptide and cognitive decline in older adults at high cardiovascular risk
    Liselotte W Wijsman
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands
    Ann Neurol 76:213-22. 2014
    ..The aim of this study was to investigate the association of NT-proBNP with cognitive function and decline in older adults at high risk of cardiovascular disease...
  19. pmc Prognostic value of cardiovascular disease status: the Leiden 85-plus study
    Petra G van Peet
    Department of Public Health and Primary Care, Leiden University Medical Center, Postzone V0 P, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Age (Dordr) 35:1433-44. 2013
    ....
  20. doi request reprint Framingham stroke risk score and cognitive impairment for predicting first-time stroke in the oldest old
    Behnam Sabayan
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Stroke 44:1866-71. 2013
    ..Our aim was to compare the Framingham stroke risk score with cognitive functioning for predicting first-time stroke in a cohort of the oldest old individuals...
  21. pmc Statin Use and Self-Reported Hindering Muscle Complaints in Older Persons: A Population Based Study
    Milly A van der Ploeg
    Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 11:e0166857. 2016
    ..Research on statin related side effects in older persons is relatively scarce. We therefore investigated the relation between statin use and self-reported hindering muscle complaints in older persons in the general population...
  22. ncbi request reprint Structural Covariance Networks and Their Association with Age, Features of Cerebral Small-Vessel Disease, and Cognitive Functioning in Older Persons
    Jessica C Foster-Dingley
    1 Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
    Brain Connect 6:681-690. 2016
    ..This indicates the potential of SCNs in substantiating cognitive functioning in older persons...
  23. doi request reprint Effect of discontinuation of antihypertensive medication on orthostatic hypotension in older persons with mild cognitive impairment: the DANTE Study Leiden
    Justine E F Moonen
    Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
    Age Ageing 45:249-55. 2016
    ..the relationship between antihypertensive medication and orthostatic hypotension in older persons remains ambiguous, due to conflicting observational evidence and lack of data of clinical trials...
  24. pmc Drug prescription rates in secondary cardiovascular prevention in old age: Do vulnerability and severity of the history of cardiovascular disease matter?
    Petra G van Peet
    a Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands
    Scand J Prim Health Care 33:260-8. 2015
    ..To assess the influence vulnerability and severity of cardiovascular disease (CVD), on prescription rates of secondary cardiovascular preventive drugs in old age...
  25. doi request reprint Blood Pressure Is Not Associated With Cerebral Blood Flow in Older Persons
    Jessica C Foster-Dingley
    From the Departments of Psychiatry J C F D, J E F M, R C v d M, Gerontology and Geriatrics A J M d C, Public health and Primary care W d R, and Radiology J v d G, Leiden University Medical Center, Leiden, the Netherlands and Department of Psychiatry, CAPRI, University of Antwerp, Antwerpen, Belgium R C v d M
    Hypertension 66:954-60. 2015
    ..Also, this association was not present in subgroups of more vulnerable persons, reflected by small vessel-related cerebral pathologies, lower cognition, or diabetes mellitus...
  26. doi request reprint Lower Blood Pressure and Gray Matter Integrity Loss in Older Persons
    Jessica C Foster-Dingley
    Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
    J Clin Hypertens (Greenwich) 17:630-7. 2015
    ..A lower level of BP was especially associated with worse gray matter integrity. Results suggest that not only upper but preferably lower thresholds of BP values should be observed in older persons...
  27. pmc Blood pressure variability and cardiovascular risk in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER)
    Rosalinde K E Poortvliet
    Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 7:e52438. 2012
    ..Our observations suggest variability in diastolic blood pressure is more strongly associated with vascular or total mortality than is systolic pressure variability in older high-risk subjects...
  28. doi request reprint Deprescribing Potentially Inappropriate Preventive Cardiovascular Medication: Barriers and Enablers for Patients and General Practitioners
    Clare H Luymes
    Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands
    Ann Pharmacother 50:446-54. 2016
    ..The use of preventive cardiovascular medication by patients with low cardiovascular disease (CVD) risk is potentially inappropriate...
  29. pmc NT-proBNP best predictor of cardiovascular events and cardiovascular mortality in secondary prevention in very old age: the Leiden 85-plus Study
    Petra G van Peet
    Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 8:e81400. 2013
    ..In the aging population cardiovascular disease (CVD) is highly prevalent. Identification of very old persons at high risk of recurrent CVD is difficult, since traditional risk markers loose predictive value with age...
  30. pmc Unilateral fetal-type circle of Willis anatomy causes right-left asymmetry in cerebral blood flow with pseudo-continuous arterial spin labeling: A limitation of arterial spin labeling-based cerebral blood flow measurements?
    Jurriaan Jh Barkeij Wolf
    Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    J Cereb Blood Flow Metab 36:1570-8. 2016
    ..Additionally, our data suggest that this effect is mediated by concomitant differences in flow velocity between the supplying arteries. ..
  31. pmc GPs' perspectives on secondary cardiovascular prevention in older age: a focus group study in the Netherlands
    Petra G van Peet
    Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands
    Br J Gen Pract 65:e739-47. 2015
    ..Although guidelines recommend secondary cardiovascular prevention irrespective of age, in older age the uptake of treatment is lower than in younger age groups...
  32. pmc Plasma NT-proBNP as predictor of change in functional status, cardiovascular morbidity and mortality in the oldest old: the Leiden 85-plus study
    Petra G van Peet
    Department of Public Health and Primary Care, Leiden University Medical Center, PO Box 9600, 2300, RC, Leiden, The Netherlands
    Age (Dordr) 36:9660. 2014
    ..Results suggest that NT-proBNP can help clinicians to identify very old people at high risk of functional impairment and incident cardiovascular morbidity...
  33. pmc GPs' perspectives on preventive care for older people: a focus group study
    Yvonne M Drewes
    Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands
    Br J Gen Pract 62:e765-72. 2012
    ..Preventive care traditionally aims to prevent diseases or injuries. For older people, different aims of prevention, such as maintenance of independence and wellbeing, are increasingly important...
  34. doi request reprint High blood pressure and resilience to physical and cognitive decline in the oldest old: the Leiden 85-plus Study
    Behnam Sabayan
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    J Am Geriatr Soc 60:2014-9. 2012
    ..To evaluate the association between various blood pressure (BP) measures at age 85 and future decline in physical and cognitive function the oldest old...
  35. doi request reprint Vitamin B12 and folate and the risk of anemia in old age: the Leiden 85-Plus Study
    Wendy P J den Elzen
    Department of Public Health and Primary Care, Leiden University Medical Center, Post Zone V 0 P, PO Box 9600, 2300 RC Leiden, The Netherlands
    Arch Intern Med 168:2238-44. 2008
    ..However, the effects of vitamin B(12) and folate deficiency on the development of anemia in old age have not yet been established...
  36. doi request reprint Change in calculated cardiovascular risk due to guideline revision: A cross-sectional study in the Netherlands
    Clare H Luymes
    a Department of Public Health and Primary Care, Leiden University Medical Center, The Netherlands
    Eur J Gen Pract 21:217-23. 2015
    ..Guidelines and accompanying risk charts concerning cardiovascular risk management (CVRM) are regularly revised worldwide...
  37. doi request reprint Increase in N-terminal pro-brain natriuretic peptide levels, renal function and cardiac disease in the oldest old
    Rosalinde Poortvliet
    Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands
    Age Ageing 44:841-7. 2015
    ..the impact of renal function and its changes and the occurrence of cardiovascular events on changes in N-terminal pro-brain natriuretic peptide levels (NT-proBNP) is unknown in very old age...
  38. doi request reprint Lower blood pressure and apathy coincide in older persons with poorer functional ability: the Discontinuation of Antihypertensive Treatment in Elderly People (DANTE) Study Leiden
    Justine E F Moonen
    Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
    J Am Geriatr Soc 63:112-7. 2015
    ..To examine the association between blood pressure (BP) measures and symptoms of apathy and depression in older adults with various levels of functional ability...