A Dahan

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. pmc Remifentanil versus fentanyl during cardiac surgery on the incidence of chronic thoracic pain (REFLECT): study protocol for a randomized controlled trial
    Sjoerd de Hoogd
    Department of Clinical Pharmacy, St Antonius Hospital, Koekoeklaan 1, 3435 CM Nieuwegein, The Netherlands
    Trials 15:466. 2014
  2. pmc De-implementation of expensive blood saving measures in hip and knee arthroplasties: study protocol for the LISBOA-II cluster randomized trial
    Veronique M A Voorn
    Department of Medical Decision Making, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands
    Implement Sci 9:48. 2014
  3. pmc Ketamine does not produce relief of neuropathic pain in mice lacking the β-common receptor (CD131)
    Maarten Swartjes
    Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 8:e71326. 2013
  4. pmc Pharmacodynamic analysis of the analgesic effect of capsaicin 8% patch (Qutenza™) in diabetic neuropathic pain patients: detection of distinct response groups
    Christian Martini
    Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    J Pain Res 5:51-9. 2012
  5. pmc Opioid chronopharmacology: influence of timing of infusion on fentanyl's analgesic efficacy in healthy human volunteers
    Merel Boom
    Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    J Pain Res 3:183-90. 2010
  6. doi ARA 290 for treatment of small fiber neuropathy in sarcoidosis
    Monique van Velzen
    Leiden University Medical Center, Department of Anesthesiology, Leiden, The Netherlands 31 71 526 2301 31 71 526 6230
    Expert Opin Investig Drugs 23:541-50. 2014
  7. pmc ARA 290, a peptide derived from the tertiary structure of erythropoietin, produces long-term relief of neuropathic pain coupled with suppression of the spinal microglia response
    Maarten Swartjes
    Department of Anesthesiology, Leiden University Medical Center, P5 Q, 2300 RC Leiden, The Netherlands
    Mol Pain 10:13. 2014
  8. pmc Remifentanil patient controlled analgesia versus epidural analgesia in labour. A multicentre randomized controlled trial
    Liv M Freeman
    Department of Obstetrics and Gynaecology, Leiden University Medical Centre, Leiden, The Netherlands
    BMC Pregnancy Childbirth 12:63. 2012
  9. pmc Effect of variations in depth of neuromuscular blockade on rating of surgical conditions by surgeon and anesthesiologist in patients undergoing laparoscopic renal or prostatic surgery (BLISS trial): study protocol for a randomized controlled trial
    Martijn Boon
    Department of Anesthesiology, Leiden University Medical Center, P5 Q, RC Leiden, 2330, The Netherlands
    Trials 14:63. 2013
  10. ncbi Pharmacovigilance: a review of opioid-induced respiratory depression in chronic pain patients
    Albert Dahan
    Department of Anesthesiology, Leiden University Medical Center, Leiden, Netherlands
    Pain Physician 16:E85-94. 2013

Collaborators

Detail Information

Publications120 found, 100 shown here

  1. pmc Remifentanil versus fentanyl during cardiac surgery on the incidence of chronic thoracic pain (REFLECT): study protocol for a randomized controlled trial
    Sjoerd de Hoogd
    Department of Clinical Pharmacy, St Antonius Hospital, Koekoeklaan 1, 3435 CM Nieuwegein, The Netherlands
    Trials 15:466. 2014
    ..Our objective is to investigate the influence of the intraoperative remifentanil on chronic postoperative pain in a prospective randomized controlled trial...
  2. pmc De-implementation of expensive blood saving measures in hip and knee arthroplasties: study protocol for the LISBOA-II cluster randomized trial
    Veronique M A Voorn
    Department of Medical Decision Making, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands
    Implement Sci 9:48. 2014
    ..The study aims to examine the effectiveness, feasibility and costs of this tailored de-implementation strategy compared to a control strategy...
  3. pmc Ketamine does not produce relief of neuropathic pain in mice lacking the β-common receptor (CD131)
    Maarten Swartjes
    Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 8:e71326. 2013
    ..Together, these results show that an intact IRR is required for the effective treatment of NP with either ketamine or ARA 290, but is not involved in ketamine's analgesic and side effects. ..
  4. pmc Pharmacodynamic analysis of the analgesic effect of capsaicin 8% patch (Qutenza™) in diabetic neuropathic pain patients: detection of distinct response groups
    Christian Martini
    Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    J Pain Res 5:51-9. 2012
    ..It is argued that this model-based approach may have added value in analyzing longitudinal chronic pain data and allows optimization of treatment algorithms for patients suffering from chronic pain conditions...
  5. pmc Opioid chronopharmacology: influence of timing of infusion on fentanyl's analgesic efficacy in healthy human volunteers
    Merel Boom
    Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    J Pain Res 3:183-90. 2010
    ....
  6. doi ARA 290 for treatment of small fiber neuropathy in sarcoidosis
    Monique van Velzen
    Leiden University Medical Center, Department of Anesthesiology, Leiden, The Netherlands 31 71 526 2301 31 71 526 6230
    Expert Opin Investig Drugs 23:541-50. 2014
    ..The limited efficacy of current treatment options dictates a rationalized design of novel compounds...
  7. pmc ARA 290, a peptide derived from the tertiary structure of erythropoietin, produces long-term relief of neuropathic pain coupled with suppression of the spinal microglia response
    Maarten Swartjes
    Department of Anesthesiology, Leiden University Medical Center, P5 Q, 2300 RC Leiden, The Netherlands
    Mol Pain 10:13. 2014
    ..In this current study, we investigated the dose-effect relationship of the tissue protective peptide ARA 290, derived from the tertiary structure of erythropoietin, on allodynia and concurrent spinal cord microglia and astrocytes...
  8. pmc Remifentanil patient controlled analgesia versus epidural analgesia in labour. A multicentre randomized controlled trial
    Liv M Freeman
    Department of Obstetrics and Gynaecology, Leiden University Medical Centre, Leiden, The Netherlands
    BMC Pregnancy Childbirth 12:63. 2012
    ..Recent studies show that epidural analgesia is superior to remifentanil patient controlled analgesia in terms of pain intensity score; however there was no difference in satisfaction with pain relief between both treatments...
  9. pmc Effect of variations in depth of neuromuscular blockade on rating of surgical conditions by surgeon and anesthesiologist in patients undergoing laparoscopic renal or prostatic surgery (BLISS trial): study protocol for a randomized controlled trial
    Martijn Boon
    Department of Anesthesiology, Leiden University Medical Center, P5 Q, RC Leiden, 2330, The Netherlands
    Trials 14:63. 2013
    ..However, with the introduction of sugammadex, rapid reversal of a deep NMB is feasible. In the current protocol, the association between the depth of NMB and rating of surgical conditions by the surgeon and anesthesiologist is studied...
  10. ncbi Pharmacovigilance: a review of opioid-induced respiratory depression in chronic pain patients
    Albert Dahan
    Department of Anesthesiology, Leiden University Medical Center, Leiden, Netherlands
    Pain Physician 16:E85-94. 2013
    ..There are no good quality case control studies or randomized controlled trials available on this topic. Here we present and analyze all case series since 1980 on OIRD in chronic pain patients extracted from PubMed...
  11. ncbi Non-analgesic effects of opioids: opioid-induced respiratory depression
    Merel Boom
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Curr Pharm Des 18:5994-6004. 2012
    ..Since this approach simultaneously enhances opioid analgesic efficacy it seems an attractive alternative to the classical reversal strategies with naloxone...
  12. doi Pharmacokinetic and pharmacodynamic considerations for NMDA receptor antagonists in the treatment of chronic neuropathic pain
    Marieke Niesters
    Leiden University Medical Center, Department of Anesthesiology, Leiden, The Netherlands
    Expert Opin Drug Metab Toxicol 8:1409-17. 2012
    ..Proof of efficacy of NMDAR inhibitors in treating neuropathic pain is limited, with the non-selective NMDAR antagonist ketamine being most effective...
  13. ncbi Influence of anaesthesia and analgesia on the control of breathing
    A Dahan
    Department of Anesthesiology, Leiden University Medical Centre LUMC P5 Q, PO Box 9600, The Netherlands
    Br J Anaesth 91:40-9. 2003
  14. pmc Plasticity of central chemoreceptors: effect of bilateral carotid body resection on central CO2 sensitivity
    Albert Dahan
    Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS Med 4:e239. 2007
    ..We assessed the acute and chronic effect of carotid body resection in three humans who underwent bilateral carotid body resection (bCBR) after developing carotid body tumors...
  15. ncbi Morphine-6-glucuronide (M6G) for postoperative pain relief
    Albert Dahan
    Department of Anesthesiology, Leiden University Medical Center, P5 Q, P O Box 9600, 2300 RC Leiden, The Netherlands
    Eur J Pain 12:403-11. 2008
    ..The present drug profile provides a review of the pharmacological properties of M6G, the clinical evidence relating to its efficacy and safety, and discusses its future role in the treatment of postoperative pain...
  16. ncbi Simultaneous measurement and integrated analysis of analgesia and respiration after an intravenous morphine infusion
    Albert Dahan
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 101:1201-9. 2004
    ..Both respiratory and pain measurements were performed over single 24-h time spans...
  17. ncbi Respiratory depression with opioids
    Albert Dahan
    Leiden University Medical Center, Leiden University, The Netherlands
    J Pain Palliat Care Pharmacother 21:63-6. 2007
    ..Respiratory depression remains one of the most feared effects of opioids. Guidelines for safe use of these important drugs are presented and clinicians are encouraged to not fear using opioids when they are clinically indicated...
  18. ncbi Opioid-induced respiratory effects: new data on buprenorphine
    Albert Dahan
    Department of Anesthesiology, Leiden University Medical Center P5 Q, P O Box 9600, 2300 RC Leiden, The Netherlands
    Palliat Med 20:s3-8. 2006
    ..In the rare instance of respiratory depression, reversal is possible with a sufficient and continuous infusion of naloxone...
  19. doi Population pharmacokinetic-pharmacodynamic modeling of ketamine-induced pain relief of chronic pain
    Albert Dahan
    Department of Anesthesiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Eur J Pain 15:258-67. 2011
    ....
  20. ncbi Comparison of the respiratory effects of intravenous buprenorphine and fentanyl in humans and rats
    A Dahan
    Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    Br J Anaesth 94:825-34. 2005
    ..To study whether an apparent ceiling effect exists for respiratory depression induced by buprenorphine, we compared the respiratory effects of buprenorphine and fentanyl in humans and rats...
  21. ncbi Buprenorphine induces ceiling in respiratory depression but not in analgesia
    A Dahan
    Department of Anesthesiology, Leiden University Medical Center PO Box 9600, 2300 RC Leiden, The Netherlands
    Br J Anaesth 96:627-32. 2006
    ..The aim of the study was to compare buprenorphine's behaviour with respect to the occurrence of ceiling (or apparent maximum) in these typical micro-opioid protein-(MOP) receptor effects...
  22. doi Incidence, Reversal, and Prevention of Opioid-induced Respiratory Depression
    Albert Dahan
    Department of Anesthesiology, Leiden University Medical Center, UK
    Anesthesiology 112:226-38. 2010
    ..New approaches to prevent opioid respiratory depression without affecting analgesia have led to the experimental application of serotinine agonists, ampakines, and the antibiotic minocycline...
  23. ncbi Plasticity in the brain: influence of bilateral carotid body resection (bCBR) on central CO2 sensitivity
    Albert Dahan
    Leiden University Medical Center, Department of Anesthesiology, 2300 RC Leiden, The Netherlands
    Adv Exp Med Biol 605:312-6. 2008
    ....
  24. doi Sex-specific responses to opiates: animal and human studies
    Albert Dahan
    Department of Anesthesiology, Leiden University Medical Center, P5 Q, 2300 RC Leiden, The Netherlands
    Anesth Analg 107:83-95. 2008
    ....
  25. ncbi The involvement of the mu-opioid receptor in ketamine-induced respiratory depression and antinociception
    E Sarton
    Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    Anesth Analg 93:1495-500, table of contents. 2001
    ....
  26. ncbi Response surface modeling of alfentanil-sevoflurane interaction on cardiorespiratory control and bispectral index
    A Dahan
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 94:982-91. 2001
    ..The authors examined the influence of the combined administration of sevoflurane and alfentanil on ventilatory control, heart rate (HR), and Bispectral Index (BIS) in healthy volunteers...
  27. ncbi Mechanism-based PK/PD modeling of the respiratory depressant effect of buprenorphine and fentanyl in healthy volunteers
    A Yassen
    Department of Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden, The Netherlands
    Clin Pharmacol Ther 81:50-8. 2007
    ..56, 95% confidence interval (CI): 0.50-0.62), whereas fentanyl displayed full respiratory depressant effect (alpha=0.91, 95% CI: 0.19-1.62)...
  28. ncbi Opioid effect on breathing frequency and thermogenesis in mice lacking exon 2 of the mu-opioid receptor gene
    E Sarton
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Adv Exp Med Biol 499:399-404. 2001
  29. ncbi Comparison of morphine-6-glucuronide and morphine on respiratory depressant and antinociceptive responses in wild type and mu-opioid receptor deficient mice
    R Romberg
    Department of Anesthesiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Br J Anaesth 91:862-70. 2003
    ..The influence of M6G on respiratory and antinociceptive responses was investigated in mice lacking the micro -opioid receptor (MOR) and compared with morphine...
  30. ncbi Ventilatory response to hypoxia in humans. Influences of subanesthetic desflurane
    A Dahan
    Department of Anesthesiology, Leiden University Hospital, The Netherlands
    Anesthesiology 85:60-8. 1996
    ..In the current study, the influence of subanesthetic desflurane (0.1 minimum alveolar concentration [MAC]) on the isocapnic hypoxic ventilatory response was assessed in healthy volunteers during normocapnia and hypercapnia...
  31. doi Propofol reduces the distribution and clearance of midazolam
    Bart Jan Lichtenbelt
    Department of Anesthesiology, University Medical Center, Groningen, University of Groningen, Groningen, The Netherlands
    Anesth Analg 110:1597-606. 2010
    ..Midazolam, at sedative levels, increases blood propofol concentrations by 25%. We evaluated the reverse interaction and determined the influence of propofol on the pharmacokinetics of midazolam...
  32. ncbi Mechanism-based pharmacokinetic-pharmacodynamic modelling of the reversal of buprenorphine-induced respiratory depression by naloxone : a study in healthy volunteers
    Ashraf Yassen
    Division of Pharmacology, Leiden Amsterdam Centre for Drug Research, Leiden, The Netherlands
    Clin Pharmacokinet 46:965-80. 2007
    ..The aim of this study was to characterise the pharmacodynamic interaction between buprenorphine and naloxone in healthy volunteers...
  33. ncbi Sex-related differences in the influence of morphine on ventilatory control in humans
    A Dahan
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 88:903-13. 1998
    ..Opiate agonists have different analgesic effects in male and female patients. The authors describe the influence of sex on the respiratory pharmacology of the mu-receptor agonist morphine...
  34. ncbi Speed of onset and offset and mechanisms of ventilatory depression from sevoflurane: an experimental study in the cat
    A Dahan
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 90:1119-28. 1999
    ..To learn more about the mechanisms of sevoflurane-induced respiratory depression, the authors also studied its influence on the dynamic ventilatory response to carbon dioxide...
  35. ncbi Sex differences in morphine-induced ventilatory depression reside within the peripheral chemoreflex loop
    E Sarton
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 90:1329-38. 1999
    ..This study gathers information in humans on the sites of sex-related differences in ventilatory depression caused by the mu-opioid receptor agonist morphine...
  36. doi Permutation entropy of the electroencephalogram: a measure of anaesthetic drug effect
    E Olofsen
    Department of Anesthesiology, Leiden University Medical Center, Leiden University, Leiden, The Netherlands
    Br J Anaesth 101:810-21. 2008
    ....
  37. pmc Pharmacokinetic-pharmacodynamic modeling of the effectiveness and safety of buprenorphine and fentanyl in rats
    Ashraf Yassen
    Division of Pharmacology, Gorlaeus Laboratories, Leiden Amsterdam Center for Drug Research, Leiden, The Netherlands
    Pharm Res 25:183-93. 2008
    ..The objective of this investigation was to characterize the relationship between buprenorphine or fentanyl exposure and the effectiveness and safety outcome in rats...
  38. ncbi Pharmacokinetic-pharmacodynamic modeling of morphine-6-glucuronide-induced analgesia in healthy volunteers: absence of sex differences
    Raymonda Romberg
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 100:120-33. 2004
    ....
  39. ncbi Response surface modeling of remifentanil-propofol interaction on cardiorespiratory control and bispectral index
    Diederik J F Nieuwenhuijs
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 98:312-22. 2003
    ..Since propofol and remifentanil are frequently combined for monitored anesthesia care, we examined the influence of the separate and combined administration of these agents on cardiorespiratory control and bispectral index in humans...
  40. ncbi Acetazolamide and breathing. Does a clinical dose alter peripheral and central CO(2) sensitivity?
    L J Teppema
    Department of Physiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Respir Crit Care Med 160:1592-7. 1999
    ..08 +/- 1.20 to -7.48 +/- 2.07 mmol. L(-1), indicating metabolic acidosis and explaining a leftward shift of the CO(2) response curve by 7.3 mm Hg. Possible clinical implications of these results are discussed...
  41. ncbi Antioxidants reverse reduction of the human hypoxic ventilatory response by subanesthetic isoflurane
    Luc J Teppema
    Department of Anesthesiology, Leiden University Medical Center, PO Box 9604, 2300 RC Leiden, The Netherlands
    Anesthesiology 102:747-53. 2005
    ..To examine a possible involvement of reactive oxygen species or changes in redox state in this inhibiting effect, the authors studied the effect of antioxidants on the isoflurane-induced reduction of the AHR in humans...
  42. doi Influence of ketamine and morphine on descending pain modulation in chronic pain patients: a randomized placebo-controlled cross-over proof-of-concept study
    M Niesters
    Department of Anesthesiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Br J Anaesth 110:1010-6. 2013
    ..Dysfunction is associated with various chronic pain states. Here, the effect of ketamine and morphine on descending inhibition is examined using the conditioned pain modulation (CPM) paradigm in chronic neuropathic pain patients...
  43. doi High-inspired oxygen concentration further impairs opioid-induced respiratory depression
    M Niesters
    Department of Anesthesiology, Leiden University Medical Center, P5 Q, PO Box 9600, 2300 RC Leiden, The Netherlands
    Br J Anaesth 110:837-41. 2013
    ..We examined the effect of a single dose of remifentanil in healthy volunteers inhaling room air vs air enriched with 50% oxygen...
  44. ncbi Respiratory sites of action of propofol: absence of depression of peripheral chemoreflex loop by low-dose propofol
    D Nieuwenhuijs
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 95:889-95. 2001
    ..In contrast to low-dose inhalational anesthetics, the peripheral chemoreflex loop, when stimulated with carbon dioxide, remains unaffected by propofol...
  45. ncbi The epidural "top-up" in combined spinal-epidural anesthesia: the effect of volume versus dose
    R Stienstra
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesth Analg 88:810-4. 1999
    ....
  46. pmc Low-dose acetazolamide reduces CO(2)-O(2) stimulus interaction within the peripheral chemoreceptors in the anaesthetised cat
    L J Teppema
    Department of Physiology, Leiden University Medical Centre, PO Box 9604, 2300 RC Leiden, The Netherlands
    J Physiol 537:221-9. 2001
    ....
  47. doi Differential effect of morphine and morphine-6-glucuronide on the control of breathing in the anesthetized cat
    Luc J Teppema
    Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    Anesthesiology 109:689-97. 2008
    ..The authors compared the effects of M6G and morphine on breathing in the anesthetized cat and assessed whether 3mNTX reversal was selective for M6G...
  48. ncbi Alfentanil and placebo analgesia: no sex differences detected in models of experimental pain
    Erik Olofsen
    Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    Anesthesiology 103:130-9. 2005
    ....
  49. ncbi Influence of propofol on the control of breathing
    Albert Dahan
    Department of Anaesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    Adv Exp Med Biol 523:81-92. 2003
  50. ncbi A comparison of the efficacy of levobupivacaine 0.125%, ropivacaine 0.125% and ropivacaine 0.2%, all combined with sufentanil 0.5 microg/mL, in patient-controlled epidural analgesia after hysterectomy under combined epidural and general anesthesia
    E Sitsen
    Department of Anesthesiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Acta Anaesthesiol Belg 63:169-75. 2012
    ..We compared the relative potencies of ropivacaine and levobupivacaine in combination with sufentanil 0.5 microg/ml in postoperative epidural analgesia after abdominal hysterectomy...
  51. ncbi Anesthetic potency and influence of morphine and sevoflurane on respiration in mu-opioid receptor knockout mice
    A Dahan
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 94:824-32. 2001
    ..The involvement of the mu-opioid receptor (muOR) system in the control of breathing, anesthetic potency, and morphine- and anesthesia-induced respiratory depression was investigated in mice lacking the muOR...
  52. doi Arterial and venous pharmacokinetics of morphine-6-glucuronide and impact of sample site on pharmacodynamic parameter estimates
    Erik Olofsen
    Department of Anesthesiology, Leiden University Medical Center, P5 Q, 2300 RC Leiden, The Netherlands
    Anesth Analg 111:626-32. 2010
    ..We used simulation studies to estimate possible biases in pharmacodynamic model parameters when linking venous versus arterial concentrations to effect...
  53. ncbi A randomized, double-blind, placebo-controlled pilot study of IV morphine-6-glucuronide for postoperative pain relief after knee replacement surgery
    Raymonda Romberg
    Department of Anesthesiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Clin J Pain 23:197-203. 2007
    ..To determine the dose-response effect of intravenous morphine-6-glucuronide (M6G) on acute postoperative pain...
  54. doi Morphine-6beta-glucuronide rapidly increases pain sensitivity independently of opioid receptor activity in mice and humans
    Eveline L A van Dorp
    Leiden University Medical Center, Leiden, The Netherlands
    Anesthesiology 110:1356-63. 2009
    ..The authors tested mice and humans for M6G hyperalgesia and assessed the contribution of N-methyl-D-aspartate receptor activity in mice...
  55. doi S(+)-ketamine effect on experimental pain and cardiac output: a population pharmacokinetic-pharmacodynamic modeling study in healthy volunteers
    Marnix Sigtermans
    Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    Anesthesiology 111:892-903. 2009
    ..To further understand ketamine's therapeutic profile, the authors performed a population pharmacokinetic-pharmacodynamic analysis of the S(+)-ketamine analgesic and nonanalgesic effects in healthy volunteers...
  56. doi Differences in maternal temperature during labour with remifentanil patient-controlled analgesia or epidural analgesia: a randomised controlled trial
    M R Douma
    Department of Obstetrics, Leiden University Medical Center, Leiden, The Netherlands Electronic address
    Int J Obstet Anesth 24:313-22. 2015
    ..Epidural analgesia and remifentanil patient-controlled analgesia are two popular techniques for the treatment of labour pain, each with its own efficacy and toxicity...
  57. doi A randomized controlled trial and novel mathematical analysis of the analgesic effect of oxycodone versus paracetamol orodispersible tablets
    C H Martini
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Eur J Pain 19:295-304. 2015
    ....
  58. doi Opioid-induced respiratory depression in paediatrics: a review of case reports
    M Niesters
    Department of Anesthesiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Br J Anaesth 110:175-82. 2013
    ..Despite the restrictions of this approach, our analysis does yield an important insight in the development of OIRD, with specific risk factors clearly present in the data...
  59. ncbi The dynamic relationship between end-tidal sevoflurane and isoflurane concentrations and bispectral index and spectral edge frequency of the electroencephalogram
    E Olofsen
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 90:1345-53. 1999
    ..The authors analyzed the relationship between end-tidal sevoflurane and isoflurane concentrations (FET) and BIS and SEF and determined the speed of onset and offset of effect (t1/2k(e0))...
  60. ncbi Expression of c-fos in the rat brainstem after exposure to hypoxia and to normoxic and hyperoxic hypercapnia
    L J Teppema
    Department of Physiology, Leiden University, The Netherlands
    J Comp Neurol 388:169-90. 1997
    ..Possible implications for the neural control of breathing are also discussed, particularly with regard to the finding that several nuclei, not belonging to the classical brainstem respiratory centres, contained labeled cells...
  61. ncbi Influence of oral tramadol on the dynamic ventilatory response to carbon dioxide in healthy volunteers
    D Nieuwenhuijs
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Br J Anaesth 87:860-5. 2001
    ..We suggest that tramadol affects the ventilatory control system by acting at the mu-opioid receptors in the respiratory integrating centres within the brainstem...
  62. ncbi Naloxone reversal of opioid-induced respiratory depression with special emphasis on the partial agonist/antagonist buprenorphine
    Elise Sarton
    Leiden University Medical Center, Department of Anesthesiology, 2300 RC Leiden, The Netherlands
    Adv Exp Med Biol 605:486-91. 2008
    ..The bell-shaped reversal curve may be related to the existence of two mu-opioid receptor subtypes, one mediating the agonist effects of opioids at low dose, the other mediating antagonistic effects at high dose...
  63. doi Modeling the non-steady state respiratory effects of remifentanil in awake and propofol-sedated healthy volunteers
    Erik Olofsen
    Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    Anesthesiology 112:1382-95. 2010
    ..The authors measured the effect of remifentanil on respiration and developed a model of remifentanil-induced respiratory depression...
  64. ncbi Morphine-6-glucuronide: potency and safety compared with morphine
    Eveline L A van Dorp
    Leiden University Medical Centre, Department of Anesthesiology, P5 Q, PO Box 9600, 2300 RC Leiden, The Netherlands
    Expert Opin Pharmacother 9:1955-61. 2008
    ..The search for opioid analgesics with a better side-effect profile than morphine has led to a morphine metabolites, morphine-6-glucuronide (M6G)...
  65. doi Naloxone reversal of morphine- and morphine-6-glucuronide-induced respiratory depression in healthy volunteers: a mechanism-based pharmacokinetic-pharmacodynamic modeling study
    Erik Olofsen
    Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    Anesthesiology 112:1417-27. 2010
    ..However, to fully understand the complex opioid agonist-antagonist interaction, the effects of various naloxone doses on morphine and morphine-6-glucuronide (M6G)-induced respiratory depression were studied in healthy volunteers...
  66. pmc Sdhd and SDHD/H19 knockout mice do not develop paraganglioma or pheochromocytoma
    Jean Pierre Bayley
    Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 4:e7987. 2009
    ..SDHD is remarkable in showing an 'imprinted' tumor suppressor phenotype. Mutations of SDHD show a very high penetrance in man and we postulated that knockout of Sdhd would lead to the development of PGL/PC, probably in aged mice...
  67. doi The ventilatory response to hypoxia in mammals: mechanisms, measurement, and analysis
    Luc J Teppema
    Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    Physiol Rev 90:675-754. 2010
    ..We also briefly summarize the techniques used in small animals and in humans to measure the HVR and discuss the specific difficulties encountered in its measurement and analysis...
  68. doi Mixed-effects modeling of the influence of midazolam on propofol pharmacokinetics
    Jaap Vuyk
    Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    Anesth Analg 108:1522-30. 2009
    ..Midazolam is often used as a preoperative sedative in advance of a propofol-based anesthetic. In this study, we identified the influence of midazolam on the pharmacokinetics of propofol...
  69. doi Arterial [H+] and the ventilatory response to hypoxia in humans: influence of acetazolamide-induced metabolic acidosis
    Luc J Teppema
    Department of Anesthesiology, Leiden University Medical Center, PO Box 9600 2300 RC, Leiden, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 298:L89-95. 2010
    ..A specific inhibitory effect of acetazolamide on hypoxic sensitivity was not demonstrated...
  70. ncbi Postoperative epidural analgesia after total knee arthroplasty with sufentanil 1 microg/ml combined with ropivacaine 0.2%, ropivacaine 0.125%, or levobupivacaine 0.125%: a randomized, double-blind comparison
    Elske Sitsen
    Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    Reg Anesth Pain Med 32:475-80. 2007
    ..2% and 0.125%) and levobupivacaine (0.125%), all in combination with sufentanil 1 microg/mL with regard to postoperative pain relief and absence of motor block in a patient-controlled epidural analgesia setting...
  71. pmc Antioxidants reverse depression of the hypoxic ventilatory response by acetazolamide in man
    Luc J Teppema
    Department of Anaesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    J Physiol 572:849-56. 2006
    ..The novel findings of this study may have clinical implications, for example with regard to a combined use of acetazolamide and antioxidants at high altitude...
  72. pmc The carbonic anhydrase inhibitors methazolamide and acetazolamide have different effects on the hypoxic ventilatory response in the anaesthetized cat
    Luc J Teppema
    Department of Anesthesiolgy, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Physiol 574:565-72. 2006
    ..This suggests that normal carbonic anhydrase activity is not necessary for a normal hypoxic ventilatory response to occur. The mechanism by which acetazolamide reduces the hypoxic ventilatory response needs further study...
  73. ncbi Pharmacodynamic effect of morphine-6-glucuronide versus morphine on hypoxic and hypercapnic breathing in healthy volunteers
    Raymonda Romberg
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 99:788-98. 2003
    ..Because M6G will be on the market in the near future, the authors assessed the time profile and relative potency of M6G's effect versus morphine's effect on carbon dioxide-driven and hypoxic breathing...
  74. ncbi Low bispectral index values in awake volunteers receiving a combination of propofol and midazolam
    Jaap Vuyk
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 100:179-81. 2004
  75. ncbi Low-dose acetazolamide reduces the hypoxic ventilatory response in the anesthetized cat
    Luc J Teppema
    Department of Anesthesiology, Leiden University Medical Center, PO Box 9604, 2300 RC Leiden, The Netherlands
    Respir Physiol Neurobiol 140:43-51. 2004
    ....
  76. ncbi Respiratory depression by tramadol in the cat: involvement of opioid receptors
    Luc J Teppema
    Department of Physiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 98:420-7. 2003
    ..The aim of this study was to examine whether tramadol causes dose-dependent inhibitory effects on the ventilatory carbon dioxide response curve and whether these are reversible or can be prevented by naloxone...
  77. ncbi Acetazolamide improves cerebral oxygenation during exercise at high altitude
    Jaap Vuyk
    Department of Anesthesiology, Leiden University Medical Centre, Leiden, The Netherlands
    High Alt Med Biol 7:290-301. 2006
    ..This effect is nullified after several weeks at altitude due to acclimatization in climbers not taking Actz...
  78. pmc Antioxidants prevent depression of the acute hypoxic ventilatory response by subanaesthetic halothane in men
    Luc J Teppema
    Department of Physiology, Leiden University Medical Centre, The Netherlands
    J Physiol 544:931-8. 2002
    ..Our findings may also suggest that reactive species have an inhibiting effect on the acute hypoxic ventilatory response...
  79. ncbi Inspired carbon dioxide during hypoxia: effects on task performance and cerebral oxygen saturation
    Eveline van Dorp
    Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    Aviat Space Environ Med 78:666-72. 2007
    ..We studied the effect of added inspired CO2 during artificially induced hypoxic normobaric hypoxia (oxygen saturation approximately 80%) on complex task performance...
  80. ncbi Gender differences in morphine pharmacokinetics and dynamics
    Elise Sarton
    Department of Anaesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    Adv Exp Med Biol 523:71-80. 2003
  81. pmc Population pharmacokinetics/pharmacodynamics of anesthetics
    Erik Olofsen
    Department of Anesthesiology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    AAPS J 7:E383-9. 2005
    ....
  82. ncbi The influence of remifentanil on the dynamic relationship between sevoflurane and surrogate anesthetic effect measures derived from the EEG
    Erik Olofsen
    Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    Anesthesiology 96:555-64. 2002
    ....
  83. doi Effect of subanaesthetic ketamine on plasma and saliva cortisol secretion
    N Khalili-Mahani
    Department of Anesthesiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Br J Anaesth 115:68-75. 2015
    ..In this study we assess the effect of ketamine on the stress system by measuring plasma and saliva cortisol production during and following exposure to low-dose ketamine...
  84. doi A novel approach to identify responder subgroups and predictors of response to low- and high-dose capsaicin patches in postherpetic neuralgia
    C H Martini
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Eur J Pain 17:1491-501. 2013
    ..An alternative approach is the identification of specific patient subgroups characterized by differential response patterns in their analgesic response and to determine the presence of significant predictors of effect...
  85. doi Tapentadol potentiates descending pain inhibition in chronic pain patients with diabetic polyneuropathy
    M Niesters
    Department of Anesthesiology, Leiden University Medical Center, P5 Q, PO Box 9600, 2300 RC Leiden, The Netherlands
    Br J Anaesth 113:148-56. 2014
    ....
  86. doi Validation of a novel respiratory rate monitor based on exhaled humidity
    M Niesters
    Department of Anesthesiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Br J Anaesth 109:981-9. 2012
    ..measurement is inadequate when used with supplemental oxygen and ECG-derived RR is subject to artifacts. A new monitor measures RR by quantifying the humidity of exhaled air (respiR8(®))...
  87. ncbi Transient neurological symptoms with subarachnoid lidocaine: effect of early mobilization
    B G Cramer
    Leiden University Medical Center, Department of Anesthesiology, Leiden, The Netherlands
    Eur J Anaesthesiol 22:35-9. 2005
    ..The purpose of this study was to examine the effect of early ambulation on the incidence of transient neurological symptoms after single injection spinal anaesthesia with lidocaine 2%...
  88. ncbi Lumbar epidural catheter insertion: the midline vs. the paramedian approach
    M Leeda
    Leiden University Medical Center, Department of Anesthesiology, Leiden, The Netherlands
    Eur J Anaesthesiol 22:839-42. 2005
    ..In addition to the type of approach, the prognostic value of Patients characteristics variables with regard to the incidence of paraesthesias was assessed...
  89. doi A randomised comparison of intravenous remifentanil patient-controlled analgesia with epidural ropivacaine/sufentanil during labour
    M R Douma
    Department of Obstetrics, Leiden University Medical Center, Leiden, The Netherlands
    Int J Obstet Anesth 20:118-23. 2011
    ..We aimed to compare the efficacy of intravenous remifentanil patient-controlled analgesia with epidural ropivacaine/sufentanil during labour...
  90. ncbi Morphine-6-glucuronide: morphine's successor for postoperative pain relief?
    Eveline L A van Dorp
    Department of Anesthesiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Anesth Analg 102:1789-97. 2006
    ..Although the data from the literature are very promising, we believe that more studies are necessary before we may conclude that M6G is superior to morphine for postoperative analgesia...
  91. doi An observational study on the effect of S+-ketamine on chronic pain versus experimental acute pain in Complex Regional Pain Syndrome type 1 patients
    Marnix Sigtermans
    Department of Anesthesiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Eur J Pain 14:302-7. 2010
    ..The aim of the study was to explore the analgesic effect of the N-methyl-d-aspartate receptor (NMDAR) antagonist ketamine in acute experimental versus chronic spontaneous pain in Complex Regional Pain Syndrome type 1 (CRPS-1) patients...
  92. ncbi Carotid body tumors in humans caused by a mutation in the gene for succinate dehydrogenase D (SDHD)
    Albert Dahan
    Department of Anesthesiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Adv Exp Med Biol 551:71-6. 2004
  93. ncbi Naloxone reversal of buprenorphine-induced respiratory depression
    Eveline van Dorp
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 105:51-7. 2006
    ..The studies were designed in light of the claims that buprenorphine is relatively resistant to the effects of naloxone...
  94. ncbi Fentanyl, a upsilon-opioid receptor agonist, phase shifts the hamster circadian pacemaker
    J H Meijer
    Department of Physiology, Leiden University Medical Center, Leiden, The Netherlands
    Brain Res 868:135-40. 2000
    ..The present data suggest that there is some role for opioid regulation of the circadian system...
  95. ncbi Differential responses of circadian activity onset and offset following GABA-ergic and opioid receptor activation
    Mariska J Vansteensel
    Department of Neurophysiology, Leiden University Medical Center, P O Box 9604, 2300 RC Leiden, The Netherlands
    J Biol Rhythms 18:297-306. 2003
    ..The data implicate that the early subjective day is an interesting phase for analysis of molecular and biochemical processes involved in nonphotic phase shifting...
  96. ncbi Antioxidants prevent blunting of hypoxic ventilatory response by low-dose halothane
    Albert Dahan
    Department of Anesthesiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Adv Exp Med Biol 551:217-20. 2004
  97. ncbi Animal-to-human extrapolation of the pharmacokinetic and pharmacodynamic properties of buprenorphine
    Ashraf Yassen
    Leiden Amsterdam Center for Drug Research, Division of Pharmacology, Gorleaus Laboratories, Leiden, The Netherlands
    Clin Pharmacokinet 46:433-47. 2007
    ..This investigation describes the interspecies scaling of the pharmacokinetics and pharmacodynamics of buprenorphine...
  98. doi Population pharmacokinetic-pharmacodynamic modeling of epidural anesthesia
    Erik Olofsen
    Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    Anesthesiology 109:664-74. 2008
    ..The current study was designed to develop a population pharmacokinetic-pharmacodynamic model capable of linking the kinetic data to the analgesic effects of these local anesthetics (i.e., sensory neural blockade)...
  99. ncbi Polymorphism of mu-opioid receptor gene (OPRM1:c.118A>G) does not protect against opioid-induced respiratory depression despite reduced analgesic response
    Raymonda R Romberg
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 102:522-30. 2005
    ..118A>G) was investigated on morphine-6-glucuronide (M6G)-induced analgesia and respiratory depression in a group of healthy volunteers...
  100. doi Ketamine for the treatment of chronic non-cancer pain
    Ingeborg Noppers
    Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    Expert Opin Pharmacother 11:2417-29. 2010
    ..Ketamine (introduced in the 1960s as an anesthetic) is the most studied NMDAR antagonist in the treatment of various chronic pain syndromes...
  101. doi Do sex differences exist in opioid analgesia? A systematic review and meta-analysis of human experimental and clinical studies
    Marieke Niesters
    Department of Anesthesiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Pain 151:61-8. 2010
    ..The data on non-morphine μ and mixed μ/κ-opioids are less convincing and require further study...