Leiden University Medical Center

Summary

Organization: Leiden University Medical Center
Country: The Netherlands

Top Publications

  1. ncbi [Migraine and depression should be treated concurrently]
    Mark A Louter
    Leids Universitair Medisch Centrum, afd Neurologie, Leiden, The Netherlands
    Ned Tijdschr Geneeskd 154:A1044. 2010
  2. doi Elevated CRP levels are associated with increased carotid atherosclerosis independent of visceral obesity
    Reza Alizadeh Dehnavi
    Department of General Internal Medicine and Endocrinology, Leiden University Medical Centre, Leiden, The Netherlands
    Atherosclerosis 200:417-23. 2008
  3. doi Symptom severity but not psychopathology predicts visceral hypersensitivity in irritable bowel syndrome
    Patrick P J van der Veek
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands
    Clin Gastroenterol Hepatol 6:321-8. 2008
  4. doi Multiple testing on the directed acyclic graph of gene ontology
    Jelle J Goeman
    Department of Medical Statistics, Postzone S5 P, P O Box 9600, 2300 RC Leiden, The Netherlands
    Bioinformatics 24:537-44. 2008
  5. ncbi Administration route-dependent effects of estrogens on IGF-I levels during fixed GH replacement in women with hypopituitarism
    Agatha A van der Klaauw
    Department of Endocrinology and Metabolic Diseases C4 R, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands
    Eur J Endocrinol 157:709-16. 2007
  6. ncbi Fetal and neonatal alloimmune thrombocytopenia
    Eline S A van den Akker
    Department of Obstetrics, Leiden University Medical Centre, The Netherlands
    Best Pract Res Clin Obstet Gynaecol 22:3-14. 2008
  7. ncbi Lobar distribution of changes in gray matter and white matter in memory clinic patients: detected using magnetization transfer imaging
    A C G M van Es
    Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    AJNR Am J Neuroradiol 28:1938-42. 2007
  8. ncbi Vaginal blood flow after radical hysterectomy with and without nerve sparing. A preliminary report
    Q D Pieterse
    Department of Gynaecology, Leiden University Medical Centre, Leiden, The Netherlands
    Int J Gynecol Cancer 18:576-83. 2008
  9. ncbi Cotransplantation of ex vivo expanded mesenchymal stem cells accelerates lymphocyte recovery and may reduce the risk of graft failure in haploidentical hematopoietic stem-cell transplantation
    Lynne M Ball
    Department of Pediatric Stem Cell Transplantation, Leiden University Medical Centre, Leiden, The Netherlands
    Blood 110:2764-7. 2007
  10. ncbi Peritubular endothelium: the Achilles heel of the kidney?
    T J Rabelink
    Department of Nephrology, Einthoven Centre of Experimental Vascular Medicine and Diabetes, Leiden University Medical Center, Leiden, The Netherlands
    Kidney Int 72:926-30. 2007

Detail Information

Publications62

  1. ncbi [Migraine and depression should be treated concurrently]
    Mark A Louter
    Leids Universitair Medisch Centrum, afd Neurologie, Leiden, The Netherlands
    Ned Tijdschr Geneeskd 154:A1044. 2010
    ..It is recommended that different hospital specialists should be involved in both the diagnosis and treatment of patients with comorbidity of migraine and depression...
  2. doi Elevated CRP levels are associated with increased carotid atherosclerosis independent of visceral obesity
    Reza Alizadeh Dehnavi
    Department of General Internal Medicine and Endocrinology, Leiden University Medical Centre, Leiden, The Netherlands
    Atherosclerosis 200:417-23. 2008
    ..Elevated C-reactive protein (CRP) levels are associated with VO and cardiovascular disease. After exploring the relation between CRP and VO, we aimed to evaluate the VO independent relation between CRP and carotid atherosclerosis...
  3. doi Symptom severity but not psychopathology predicts visceral hypersensitivity in irritable bowel syndrome
    Patrick P J van der Veek
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands
    Clin Gastroenterol Hepatol 6:321-8. 2008
    ....
  4. doi Multiple testing on the directed acyclic graph of gene ontology
    Jelle J Goeman
    Department of Medical Statistics, Postzone S5 P, P O Box 9600, 2300 RC Leiden, The Netherlands
    Bioinformatics 24:537-44. 2008
    ..Current methods for multiplicity adjustment do not make use of the graph structure of Gene Ontology (GO) when testing for association of expression profiles of GO terms with a response variable...
  5. ncbi Administration route-dependent effects of estrogens on IGF-I levels during fixed GH replacement in women with hypopituitarism
    Agatha A van der Klaauw
    Department of Endocrinology and Metabolic Diseases C4 R, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands
    Eur J Endocrinol 157:709-16. 2007
    ..The aim of this study was to evaluate the effects of oral versus transdermal estrogen administration at similar plasma estradiol levels on IGF-I, IGF-binding protein-3, and sex hormone-binding globulin (SHBG) concentrations...
  6. ncbi Fetal and neonatal alloimmune thrombocytopenia
    Eline S A van den Akker
    Department of Obstetrics, Leiden University Medical Centre, The Netherlands
    Best Pract Res Clin Obstet Gynaecol 22:3-14. 2008
    ..However, controversy still exists over the optimal antenatal management strategy...
  7. ncbi Lobar distribution of changes in gray matter and white matter in memory clinic patients: detected using magnetization transfer imaging
    A C G M van Es
    Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    AJNR Am J Neuroradiol 28:1938-42. 2007
    ..In this study, we assessed the lobar distribution of the GM and WM pathology over the brain and the association of lobar distribution with global cognitive decline...
  8. ncbi Vaginal blood flow after radical hysterectomy with and without nerve sparing. A preliminary report
    Q D Pieterse
    Department of Gynaecology, Leiden University Medical Centre, Leiden, The Netherlands
    Int J Gynecol Cancer 18:576-83. 2008
    ..Because it is not observed to the same extent after nerve-sparing RHL, it seems that the nerve-sparing technique leads to a better overall vaginal blood flow caused by less denervation of the vagina...
  9. ncbi Cotransplantation of ex vivo expanded mesenchymal stem cells accelerates lymphocyte recovery and may reduce the risk of graft failure in haploidentical hematopoietic stem-cell transplantation
    Lynne M Ball
    Department of Pediatric Stem Cell Transplantation, Leiden University Medical Centre, Leiden, The Netherlands
    Blood 110:2764-7. 2007
    ..These data suggest that MSCs, possibly thanks to their potent immunosuppressive effect on alloreactive host T lymphocytes escaping the preparative regimen, reduce the risk of graft failure in haploidentical HSC transplant recipients...
  10. ncbi Peritubular endothelium: the Achilles heel of the kidney?
    T J Rabelink
    Department of Nephrology, Einthoven Centre of Experimental Vascular Medicine and Diabetes, Leiden University Medical Center, Leiden, The Netherlands
    Kidney Int 72:926-30. 2007
    ..In this mini review, the evidence for this pathophysiological concept as well as the possibility to detect such endothelial activation in the clinical arena is summarized...
  11. ncbi Treatment of vertebral tumor with posterior wall defect using image-guided radiofrequency ablation combined with vertebroplasty: preliminary results in 12 patients
    Edwin van der Linden
    Department of Radiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    J Vasc Interv Radiol 18:741-7. 2007
    ..To evaluate the safety and clinical benefit of vertebral tumor treatment by combined radiofrequency ablation (RFA) and vertebroplasty, for pain reduction in patients who are unable to benefit from noninvasive treatment methods...
  12. ncbi Acetazolamide improves cerebral oxygenation during exercise at high altitude
    Jaap Vuyk
    Department of Anesthesiology, Leiden University Medical Centre, Leiden, The Netherlands
    High Alt Med Biol 7:290-301. 2006
    ..This effect is nullified after several weeks at altitude due to acclimatization in climbers not taking Actz...
  13. ncbi Intraobserver and interobserver reliability of videotaped laparoscopy evaluations for endometriosis and adhesions
    Philomeen T M Weijenborg
    Department of Gynecology, Leiden University Medical Center, Leiden, The Netherlands
    Fertil Steril 87:373-80. 2007
    ..To determine the intra- and interobserver reliability of evaluations during videotaped laparoscopy, with real-time laparoscopy as the "gold standard."..
  14. ncbi Overranging in multisection CT: quantification and relative contribution to dose--comparison of four 16-section CT scanners
    Aart J van der Molen
    Department of Radiology C 2S, Leiden University Medical Center, Albinusdreef 2, NL 2333 ZA Leiden, The Netherlands
    Radiology 242:208-16. 2007
    ..To quantify the number of overrange rotations and to assess their relative contribution to organ and effective doses at 16-section body computed tomography (CT)...
  15. doi Genome-wide linkage scan for atypical nevi in p16-Leiden melanoma families
    Femke A De Snoo
    Departments of Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Hum Genet 16:1135-41. 2008
    ..The strongest evidence for an atypical nevus susceptibility gene was mapped to chromosome band 7q21.3 (two-point LOD score=2.751), a region containing candidate gene CDK6...
  16. doi Translating basic research into clinical rheumatology
    D Van der Woude
    Leiden University Medical Center, Department of Rheumatology, Albinusdreef 2, 2300 RC Leiden, The Netherlands
    Best Pract Res Clin Rheumatol 22:299-310. 2008
    ....
  17. doi Beta-papillomavirus infection and skin cancer
    Jan Nico Bouwes Bavinck
    Department of Dermatology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    J Invest Dermatol 128:1355-8. 2008
    ..Human papillomaviruses are most likely indirectly involved in this process by facilitating UV-related carcinogenesis via preventing UV-induced apoptosis or impairing DNA repair, but other mechanisms are also possible...
  18. doi Correlates of apathy in Huntington's disease
    E van Duijn
    Leiden University Medical Center, Department of Psychiatry, B1 P, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Neuropsychiatry Clin Neurosci 22:287-94. 2010
    ..After exclusion of 10 depressed patients, apathy was independently associated with male sex, worse global functioning, and higher use of neuroleptics and benzodiazepines...
  19. doi Additional cryptic CNVs in mentally retarded patients with apparently balanced karyotypes
    Antoinet C J Gijsbers
    Center for Human and Clinical Genetics, Leiden University Medical Center LUMC, Leiden, The Netherlands
    Eur J Med Genet 53:227-33. 2010
    ..These data demonstrate that high-resolution array screening and conventional karyotyping is necessary to tie complex karyotypes to phenotypes of MR patients...
  20. doi Lack of association between the presence and persistence of betapapillomavirus DNA in eyebrow hairs and betapapillomavirus L1 antibodies in serum
    Elsemieke I Plasmeijer
    Department of Medical Microbiology, Leiden University Medical Center, Leiden, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Gen Virol 91:2073-9. 2010
    ..Other factors, such as viral load, may play a more pivotal role in the induction of detectable seroresponses...
  21. doi Pheochromocytomas detected by biochemical screening in predisposed subjects are associated with lower prevalence of clinical and biochemical manifestations and smaller tumors than pheochromocytomas detected by signs and symptoms
    N van Duinen
    Department of Endocrinology and Metabolic Diseases, Center of Human and Clinical Genetics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Eur J Endocrinol 163:121-7. 2010
    ..Sporadic pheochromocytomas are detected by clinical signs and symptoms, whereas pheochromocytomas in patients with a known hereditary predisposition for these tumors are detected by repetitive screening for catecholamine excess...
  22. doi Validity and responsiveness of the World Health Organization Disability Assessment Schedule II to assess disability in rheumatoid arthritis patients
    Jorit J L Meesters
    Department of Rheumatology, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands
    Rheumatology (Oxford) 49:326-33. 2010
    ..To investigate the validity and responsiveness of the World Health Organization Disability Schedule II (WHODAS II) in patients with established RA...
  23. doi Distinguishing between depression and anxiety: a proposal for an extension of the tripartite model
    M E den Hollander-Gijsman
    Department of Psychiatry, Leiden University Medical Center LUMC, PO Box 9600, 2300 RC Leiden, The Netherlands
    Eur Psychiatry 25:197-205. 2010
    ..As point of departure, we used the tripartite model of Clark and Watson that discerns three dimensions: negative affect, positive affect and physiological hyperarousal...
  24. pmc Illness cognitions in head and neck squamous cell carcinoma: predicting quality of life outcome
    Margreet Scharloo
    Medical Psychology, Leiden University Medical Center, 2300 RB Leiden, The Netherlands
    Support Care Cancer 18:1137-45. 2010
    ....
  25. pmc Treatment duration of febrile urinary tract infection (FUTIRST trial): a randomized placebo-controlled multicenter trial comparing short (7 days) antibiotic treatment with conventional treatment (14 days)
    Cees van Nieuwkoop
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    BMC Infect Dis 9:131. 2009
    ..Few randomized trials showed the effectiveness of treatment durations of 5 to 7 days but this has only been studied in young previously healthy women...
  26. doi Management of the highly sensitized patient
    Frans H J Claas
    Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Curr Opin Immunol 21:569-72. 2009
    ..As none of these approaches are successful in all patients, a comprehensive use of a combination of these strategies seems the way to go...
  27. doi Quality of life after pelvic radiotherapy or vaginal brachytherapy for endometrial cancer: first results of the randomized PORTEC-2 trial
    Remi A Nout
    Department of Clinical Oncology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Oncol 27:3547-56. 2009
    ..Vaginal brachytherapy provides a better QOL, and should be the preferred treatment from a QOL perspective...
  28. doi Therapist-aided exposure for women with lifelong vaginismus: a replicated single-case design
    Moniek M ter Kuile
    Outpatient Clinic of Psychosomatic Gynecology and Sexology VRSP, Leiden University Medical Center, The Netherlands
    J Consult Clin Psychol 77:149-59. 2009
    ..Furthermore, exposure was successful in decreasing fear and negative penetration beliefs posttreatment and at 3-month and 1-year follow-ups. Therapist-aided exposure appears to be an effective treatment for lifelong vaginismus...
  29. doi Quantitative analysis of the experimental cytotoxic drug cyclopentenyl cytosine and its metabolite in plasma with HPLC tandem mass spectrometry
    Kirsten Schimmel
    Leiden University Medical Center, Department of Clinical Pharmacy and Toxicology, Leiden, The Netherlands
    Biomed Chromatogr 22:1368-73. 2008
    ..HPLC with electrospray ionization tandem mass spectrometry allowed rapid and sensitive determination of CPEC and CPEU levels in plasma...
  30. doi Responsiveness of the Michigan Hand Outcomes Questionnaire--Dutch language version in patients with rheumatoid arthritis
    Florus J van der Giesen
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Arch Phys Med Rehabil 89:1121-6. 2008
    ..To investigate the responsiveness of the Michigan Hand Outcomes Questionnaire (MHQ) in patients with rheumatoid arthritis (RA) who were treated in a multidisciplinary hand clinic...
  31. ncbi Sustained effects of recombinant GH replacement after 7 years of treatment in adults with GH deficiency
    A A van der Klaauw
    Department of Endocrinology and Metabolic Diseases C4 R, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands
    Eur J Endocrinol 155:701-8. 2006
    ..To determine whether the observed short-term beneficial effects of rhGH treatment are sustained in the long term, we evaluated biochemical and anthropometric parameters after 7 years of rhGH replacement...
  32. ncbi Cryo electron microscopy reconstructions of the Leviviridae unveil the densest icosahedral RNA packing possible
    Sjoerd H E van den Worm
    Department of Biochemistry, Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, 2300 RA, Leiden, The Netherlands
    J Mol Biol 363:858-65. 2006
    ..Strikingly, the unique RNA packing of the Leviviridae appears to deploy the most efficient method of RNA storage by obeying icosahedral symmetry...
  33. ncbi Responses to reactive oxygen intermediates and virulence of Salmonella typhimurium
    Riny Janssen
    Department of Infectious Diseases, C5 P, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Microbes Infect 5:527-34. 2003
    ..By discussing various bacterial mutants classified according to their in vitro sensitivity to superoxide, we will exemplify the complex mechanisms that Salmonella has evolved to cope with superoxide stress...
  34. ncbi Osseous localization of non-Hodgkin lymphoma shown on Tc-99m HMPAO-labeled leukocyte scintigraphy
    Christianne S J Duchateau
    Department of Nuclear Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Clin Nucl Med 28:72-3. 2003
  35. ncbi Functional characterization of the lectin pathway of complement in human serum
    Anja Roos
    Department of Nephrology, C3P, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Mol Immunol 39:655-68. 2003
    ..This assay offers novel possibilities for patient diagnostics as well as for the study of disease association with the LP...
  36. ncbi Rapamycin specifically interferes with GM-CSF signaling in human dendritic cells, leading to apoptosis via increased p27KIP1 expression
    Andrea M Woltman
    Department of Nephrology, Leiden University Medical Center, The Netherlands
    Blood 101:1439-45. 2003
    ..This mTOR/p27(KIP1)/mcl-1 survival seems unique for DCs and may provide novel opportunities to influence immune responses by specific interference with the life span of these cells...
  37. ncbi High levels of adenovirus DNA in serum correlate with fatal outcome of adenovirus infection in children after allogeneic stem-cell transplantation
    Marco W Schilham
    Department of Pediatrics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Clin Infect Dis 35:526-32. 2002
    ..Quantification of adenoviral DNA in serum may prove to be a valuable tool to diagnose and monitor AdV infection and disease in immunocompromised children...
  38. ncbi Corticosteroids prevent generation of CD34+-derived dermal dendritic cells but do not inhibit Langerhans cell development
    Andrea M Woltman
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 168:6181-8. 2002
    ..In view of the different functional capacities of dermal/interstitial DC and Langerhans cells, this might affect the overall cellular immune response...
  39. ncbi Elevated IL-16 levels in patients with systemic lupus erythematosus are associated with disease severity but not with genetic susceptibility to lupus
    L R Lard
    Department of Rheumatology, Leiden University Medical Centre, The Netherlands
    Lupus 11:181-5. 2002
    ..In conclusion, these results implicate an association of IL-16 with SLE...
  40. ncbi Early and aggressive treatment of rheumatoid arthritis patients affects the association of HLA class II antigens with progression of joint damage
    L R Lard
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 46:899-905. 2002
    ..We investigated whether early and aggressive treatment with disease-modifying antirheumatic drugs could modify this relationship...
  41. ncbi Clinical application of ropivacaine in obstetrics
    R Stienstra
    Department of Anesthesiology P5 Q, Leiden University Medical Center, The Netherlands
    Curr Top Med Chem 1:215-8. 2001
    ....
  42. ncbi The HLA Dictionary 2001: a summary of HLA-A, -B, -C, -DRB1/3/4/5, -DQB1 alleles and their association with serologically defined HLA-A, -B, -C, -DR and -DQ antigens
    G M Schreuder
    World Marrow Donor Association Quality Assurance Working Group, Leiden, The Netherlands
    Tissue Antigens 58:109-40. 2001
    ..The tables with HLA equivalents and a questionnaire for submission of serologic reaction patterns for poorly identified allelic products will also be available on the WMDA web page: http://www.worldmarrow.org...
  43. ncbi Antisense-induced exon skipping restores dystrophin expression in DMD patient derived muscle cells
    J C van Deutekom
    Department of Human and Clinical Genetics, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL Leiden, The Netherlands
    Hum Mol Genet 10:1547-54. 2001
    ..This strategy may be applicable to not only >65% of DMD mutations, but also many other genetic diseases...
  44. ncbi Opposing effects of behavioural activity and light on neurons of the suprachiasmatic nucleus
    J Schaap
    Department of Physiology, Leiden University Medical Center, Wassenaarseweg 62, PO Box 9604, 2300 RC Leiden, The Netherlands
    Eur J Neurosci 13:1955-62. 2001
    ..The opposing effects of light and activity were also found in single unit recordings, indicating that photic and behavioural stimuli interact at the level of a single neuron...
  45. ncbi Melanosome capping of keratinocytes in pigmented reconstructed epidermis--effect of ultraviolet radiation and 3-isobutyl-1-methyl-xanthine on melanogenesis
    S Gibbs
    Department of Dermatology, Leiden University Medical Centre, The Netherlands
    Pigment Cell Res 13:458-66. 2000
    ..This enables sustained application of pigment stimulators over a prolonged period of time and also repeated application of pigment stimulators to be studied...
  46. ncbi Is hypotension a major risk factor for neurological morbidity at term age in very preterm infants?
    S E Martens
    Department of Paediatrics, Leiden University Medical Center, J6 S PO Box 9600 2300 RC, Leiden, The Netherlands
    Early Hum Dev 75:79-89. 2003
    ..To investigate the influence of perinatal risk factors, especially hypotension, on neuromotor status at term in surviving preterm infants born before 32 weeks of gestation...
  47. ncbi A global test for groups of genes: testing association with a clinical outcome
    Jelle J Goeman
    Department of Medical Statistics, Leiden University Medical Center, P O Box 9604, 2300 RC Leiden, The Netherlands
    Bioinformatics 20:93-9. 2004
    ..Groups of genes may be any size from a single gene to all genes on the chip (e.g. known pathways, specific areas of the genome or clusters from a cluster analysis)...
  48. ncbi Transcriptional regulation of antigen presentation
    Peter J van den Elsen
    Department of Immunohematology and Blood Transfusion, Building 1, E3 Q, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Curr Opin Immunol 16:67-75. 2004
    ..Accordingly, recent studies include investigations into chromatin remodeling and epigenetic control mechanisms that modulate cell-type-specific transcriptional regulation of genes involved in antigen presentation...
  49. ncbi Histological age prediction from the femur in a contemporary Dutch sample. The decrease of nonremodeled bone in the anterior cortex
    George J R Maat
    Netherlands Forensic Institute, The Hague, The Netherlands
    J Forensic Sci 51:230-7. 2006
    ..A concise catalogue with micrograph examples for every 10-year period in life is available upon request...
  50. ncbi Assessing genetic effects in survival data by correlating martingale residuals with an application to age at onset of Huntington disease
    Claire M A Wintrebert
    Department of Medical Statistics, Leiden University Medical Centre, P O Box 9604, Leiden, 2300 RC, The Netherlands
    Stat Med 25:3190-200. 2006
    ..6 for relatives that share 50 per cent of their genes (sib-pairs and parent-child) and about 0.3 for relatives that share 25 per cent of their genes (grandparent-grandchild, uncle/aunt-niece/nephew)...
  51. ncbi A reappraisal of the ascending systems in man, with emphasis on the medial lemniscus
    E Marani
    Rijks Universiteit Leiden, Leiden University Medical Center, Department of Neurosurgery, The Netherlands
    Adv Anat Embryol Cell Biol 179:1-74, back page. 2005
  52. ncbi An independent role of protective HLA class II alleles in rheumatoid arthritis severity and susceptibility
    Annette H M van der Helm-van Mil
    Department of Rheumatology, Leiden University Medical Center, RC Leiden, The Netherlands
    Arthritis Rheum 52:2637-44. 2005
    ....
  53. ncbi Schistosome glycans and innate immunity
    C H Hokke
    Department of Parasitology, Centre of Infectious Diseases, Leiden University Medical Centre, Leiden, The Netherlands
    Parasite Immunol 27:257-64. 2005
    ..The relevant schistosome glycan elements and the possible mechanisms through which they act on the innate immune system are discussed in this review...
  54. ncbi Allogeneic stem cell transplantation in X-linked lymphoproliferative disease: two cases in one family and review of the literature
    A C Lankester
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Bone Marrow Transplant 36:99-105. 2005
    ..Based on these results and in order to improve the final outcome, we conclude that alloSCT should be recommended in both symptomatic and asymptomatic XLP patients...
  55. ncbi Effect of three different anaesthetic agents on the postoperative production of cardiac troponin T in paediatric cardiac surgery
    I Malagon
    Department of Anaesthesia, Leiden University Medical Centre, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands
    Br J Anaesth 94:805-9. 2005
    ..We have investigated the relationship between three anaesthetic agents, midazolam, propofol, and sevoflurane, and postoperative production of cTnT...
  56. ncbi Multiview active appearance models for simultaneous segmentation of cardiac 2- and 4-chamber long-axis magnetic resonance images
    Mehmet Uzumcu
    Division of Image Processing and Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    Invest Radiol 40:195-203. 2005
    ..In this article, we aimed to evaluate a model-based method for the simultaneous detection of 2- and 4-chamber endocardial and epicardial contours in end-diastolic and end-systolic phases of MR images...
  57. pmc The coiled-coil domain of the adenovirus type 5 protein IX is dispensable for capsid incorporation and thermostability
    Jort Vellinga
    Department of Molecular Cell Biology, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL Leiden, The Netherlands
    J Virol 79:3206-10. 2005
    ....
  58. ncbi UVB-induced leucocyte trafficking in the epidermis of photosensitive lupus erythematosus patients: normal depletion of Langerhans cells
    Artiena Soe Janssens
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands
    Exp Dermatol 14:138-42. 2005
    ..In the present study, we tested this hypothesis by investigating leucocyte trafficking in the initial phase of cutaneous LE after intense UVB exposure...
  59. pmc Diagnosis of schistosomiasis by reagent strip test for detection of circulating cathodic antigen
    G J van Dam
    Department of Parasitology, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    J Clin Microbiol 42:5458-61. 2004
    ..This assay can easily be developed to an end-user format...
  60. ncbi [Coping with grief following perinatal death: a multifaceted and natural process]
    C R Geerinck-Vercammen
    Leids Universitair Medisch Centrum, afd Verloskunde, Neonatologie en Maatschappelijk Werk, J7Q 136, Postbus 9600, 2300 RC Leiden
    Ned Tijdschr Geneeskd 148:1231-4. 2004
    ..It is recommended that the attention for the parents and their lifeless child and all care behaviour be the same, as much as possible, as after the birth of a living child...
  61. ncbi Commentary: the HRT story: vindication of old epidemiological theory
    Jan P Vandenbroucke
    Department of Clinical Epidemioloy, Leiden University Medical Centre, Bldg 1 C9 P, 2300 RC Leiden, The Netherlands
    Int J Epidemiol 33:456-7. 2004
  62. ncbi Granulocyte-colony stimulating factor impedes recovery from damage caused by cytotoxic agents through increased differentiation at the expense of self-renewal
    R van Os
    Department of Radiation Oncology, Brigham and Women s Hospital and the Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachustetts, USA
    Stem Cells 18:120-7. 2000
    ..This effect is enhanced in animals with an already compromised hematopoietic stem cell compartment as seen with repeated doses of BCNU...

Research Grants6

  1. Progression of brain lesions in migraine. The Population-Based CAMERA MRI follow-
    Michel Ferrari; Fiscal Year: 2009
    ..If confirmed, this would call for an earlier and more aggressive prophylactic treatment of migraine to prevent attacks and related brain damage. ..
  2. Progression of brain lesions in migraine. The Population-Based CAMERA MRI follow-
    MARK CHRISTIAN KRUIT; Fiscal Year: 2010
    ..If confirmed, this would call for an earlier and more aggressive prophylactic treatment of migraine to prevent attacks and related brain damage. ..
  3. Llama-derived phage display antibody arrays for FSHD
    Silvere van der Maarel; Fiscal Year: 2003
    ..Evidently, these antibodies can also be used individually for specific immunohistochemical and immunocytochemical studies. ..
  4. FSHD as a Disorder of Impaired RNA Biogenesis
    Silvere van der Maarel; Fiscal Year: 2007
    ..Moreover, on the long term, we expect that uniform myogenic cell models with well-defined disease parameters for FSHD will be of importance for pharmaceutical intervention studies. ..