Meike W Vernooij

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. doi request reprint Cerebral microbleeds: do they really predict macrobleeding?
    Meike W Vernooij
    Department of Radiology, Erasmus University Medical Center, s Gravendijkwal 230, Rotterdam 3015 CE, The Netherlands
    Int J Stroke 7:565-6. 2012
  2. doi request reprint Population imaging in neuroepidemiology
    M W Vernooij
    Departments of Radiology and Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands Electronic address
    Handb Clin Neurol 138:69-90. 2016
  3. doi request reprint Structural neuroimaging in aging and Alzheimer's disease
    Meike W Vernooij
    Department of Radiology, Erasmus MC University Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Neuroimaging Clin N Am 22:33-55, vii-viii. 2012
  4. doi request reprint Cerebral microbleeds are associated with worse cognitive function: the Rotterdam Scan Study
    M M F Poels
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Neurology 78:326-33. 2012
  5. ncbi request reprint Fiber density asymmetry of the arcuate fasciculus in relation to functional hemispheric language lateralization in both right- and left-handed healthy subjects: a combined fMRI and DTI study
    M W Vernooij
    Department of Radiology, Erasmus MC, The Netherlands Department of Epidemiology and Biostatistics, Erasmus MC, The Netherlands
    Neuroimage 35:1064-76. 2007
  6. doi request reprint White matter microstructural integrity and cognitive function in a general elderly population
    Meike W Vernooij
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Arch Gen Psychiatry 66:545-53. 2009
  7. doi request reprint Genetic loci for serum lipid fractions and intracerebral hemorrhage
    Saloua Akoudad
    Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, The Netherlands Department of Radiology, Erasmus MC, University Medical Center Rotterdam, The Netherlands Department of Neurology, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Atherosclerosis 246:287-92. 2016
  8. doi request reprint Determinants of cerebellar and cerebral volume in the general elderly population
    Yoo Young Hoogendam
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Neurobiol Aging 33:2774-81. 2012
  9. doi request reprint Alzheimer's disease genes and cognition in the nondemented general population
    Benjamin F J Verhaaren
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Biol Psychiatry 73:429-34. 2013
  10. doi request reprint Atherosclerotic calcification relates to cognitive function and to brain changes on magnetic resonance imaging
    Daniel Bos
    Department of Radiology, Erasmus MC, Rotterdam, The Netherlands
    Alzheimers Dement 8:S104-11. 2012

Detail Information

Publications95

  1. doi request reprint Cerebral microbleeds: do they really predict macrobleeding?
    Meike W Vernooij
    Department of Radiology, Erasmus University Medical Center, s Gravendijkwal 230, Rotterdam 3015 CE, The Netherlands
    Int J Stroke 7:565-6. 2012
    ..This may be related to the severity and nature of the underling vascular pathology. Future studies should therefore use a longitudinal design and not only focus on microbleed presence, but also on location and number of microbleeds...
  2. doi request reprint Population imaging in neuroepidemiology
    M W Vernooij
    Departments of Radiology and Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands Electronic address
    Handb Clin Neurol 138:69-90. 2016
    ..Considerations for future applications of imaging in neuroepidemiology are discussed against this background. ..
  3. doi request reprint Structural neuroimaging in aging and Alzheimer's disease
    Meike W Vernooij
    Department of Radiology, Erasmus MC University Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Neuroimaging Clin N Am 22:33-55, vii-viii. 2012
    ..In the second part, the role of MR imaging in the (differential) diagnosis of AD is reviewed...
  4. doi request reprint Cerebral microbleeds are associated with worse cognitive function: the Rotterdam Scan Study
    M M F Poels
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Neurology 78:326-33. 2012
    ..Cerebral microbleeds are frequently found in the general elderly population and may reflect underlying vascular disease, but their role in cognitive function is unknown...
  5. ncbi request reprint Fiber density asymmetry of the arcuate fasciculus in relation to functional hemispheric language lateralization in both right- and left-handed healthy subjects: a combined fMRI and DTI study
    M W Vernooij
    Department of Radiology, Erasmus MC, The Netherlands Department of Epidemiology and Biostatistics, Erasmus MC, The Netherlands
    Neuroimage 35:1064-76. 2007
    ..These findings have important implications for the understanding of the functional and structural lateralization of brain regions as well as for the clinical evaluation of language function...
  6. doi request reprint White matter microstructural integrity and cognitive function in a general elderly population
    Meike W Vernooij
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Arch Gen Psychiatry 66:545-53. 2009
    ..Measures reflecting white matter microstructural integrity may provide additional information to investigate the relation between white matter changes and cognition...
  7. doi request reprint Genetic loci for serum lipid fractions and intracerebral hemorrhage
    Saloua Akoudad
    Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, The Netherlands Department of Radiology, Erasmus MC, University Medical Center Rotterdam, The Netherlands Department of Neurology, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Atherosclerosis 246:287-92. 2016
    ..To ascertain whether there is a genetic basis for this inverse association, we studied established genetic loci for serum total, LDL, and HDL cholesterol, and triglycerides in their association with ICH and microbleeds...
  8. doi request reprint Determinants of cerebellar and cerebral volume in the general elderly population
    Yoo Young Hoogendam
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Neurobiol Aging 33:2774-81. 2012
    ..This study suggests that determinants of cerebellar volume do not entirely overlap with those established for cerebral volume. Furthermore, presence of infarcts or WMLs in the cerebrum can affect cerebellar volume...
  9. doi request reprint Alzheimer's disease genes and cognition in the nondemented general population
    Benjamin F J Verhaaren
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Biol Psychiatry 73:429-34. 2013
    ..Genome-wide association studies have established 11 genes for late-onset Alzheimer's disease (AD). We investigated whether these genes jointly affect cognition in a nondemented population and improve prediction of AD...
  10. doi request reprint Atherosclerotic calcification relates to cognitive function and to brain changes on magnetic resonance imaging
    Daniel Bos
    Department of Radiology, Erasmus MC, Rotterdam, The Netherlands
    Alzheimers Dement 8:S104-11. 2012
    ..This study investigates associations of atherosclerosis (measured using CT) at four locations with cognition and brain changes on magnetic resonance imaging (MRI)...
  11. ncbi request reprint Statistical analysis of structural brain connectivity
    Renske de Boer
    Biomedical Imaging Group Rotterdam, Department of Radiology, Erasmus MC, Rotterdam, The Netherlands
    Med Image Comput Comput Assist Interv 13:101-8. 2010
    ..Principal component regression outperformed all other prediction models, demonstrating the age and gender information encoded in the connectivity network...
  12. pmc The Rotterdam Scan Study: design and update up to 2012
    M Arfan Ikram
    Department of Epidemiology, Erasmus MC University Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Eur J Epidemiol 26:811-24. 2011
    ..Finally, we make recommendations for future research, which will also be the main focus of investigation in the Rotterdam Scan Study...
  13. doi request reprint Use of antithrombotic drugs and the presence of cerebral microbleeds: the Rotterdam Scan Study
    Meike W Vernooij
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Arch Neurol 66:714-20. 2009
    ..Cerebral microbleeds are hemosiderin deposits in the brain that are indicative of microangiopathy. Microbleeds in strictly lobar brain locations have been related to cerebral amyloid angiopathy, a bleeding-prone disease state...
  14. doi request reprint Intracranial carotid artery atherosclerosis and the risk of stroke in whites: the Rotterdam Study
    Daniel Bos
    Department of Radiology, Erasmus Medical Center, Rotterdam, the Netherlands2Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    JAMA Neurol 71:405-11. 2014
    ..Intracranial atherosclerosis represents a relatively unexplored, but potentially important, cause of stroke in a white population...
  15. doi request reprint Arterial stiffness is associated with carotid intraplaque hemorrhage in the general population: the Rotterdam study
    Mariana Selwaness
    From the Departments of Epidemiology M S, G C V, A H, O H F, J C M W, M W V, Radiology Q v d B, A v d L, M W V, Internal Medicine F U S M R, and Cardiology, Biomedical Engineering J J W, Erasmus MC, Rotterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 34:927-32. 2014
    ..In a population-based study, we investigated the association between arterial stiffness and the presence and composition of carotid atherosclerotic plaques...
  16. doi request reprint The Rotterdam Study: 2014 objectives and design update
    Albert Hofman
    Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Epidemiol 28:889-926. 2013
    ..erasmus-epidemiology.nl/rotterdamstudy ). This article gives the rationale of the study and its design. It also presents a summary of the major findings and an update of the objectives and methods...
  17. doi request reprint The relation of uric acid to brain atrophy and cognition: the Rotterdam Scan Study
    Benjamin F J Verhaaren
    Department of Epidemiology, Erasmus MC University Medical Center, NL 3000 CA Rotterdam, The Netherlands
    Neuroepidemiology 41:29-34. 2013
    ..However, it is unknown whether uric acid also relates to global brain changes such as brain atrophy. We therefore studied the relation of uric acid to brain atrophy and whether this is accompanied by worse cognitive function...
  18. doi request reprint Genetic loci for coronary calcification and serum lipids relate to aortic and carotid calcification
    Daniel Bos
    Departments of Radiology, Erasmus MC, Rotterdam, The Netherlands
    Circ Cardiovasc Genet 6:47-53. 2013
    ..Hence, for the current study genetic loci for coronary artery calcification and serum lipid levels, one of the strongest risk factors for atherosclerosis, were used to assess their relation with atherosclerosis in different vessel beds...
  19. ncbi request reprint Arterial stiffness and cerebral small vessel disease: the Rotterdam Scan Study
    Mariëlle M F Poels
    Department of Epidemiology, Erasmus Medical Center, University Medical Center, Rotterdam, The Netherlands
    Stroke 43:2637-42. 2012
    ..In a population-based study, we investigated the association between arterial stiffness, as measured by aortic pulse wave velocity (aPWV), and small vessel disease...
  20. doi request reprint Altered tract-specific white matter microstructure is related to poorer cognitive performance: The Rotterdam Study
    Lotte G M Cremers
    Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Neurobiol Aging 39:108-17. 2016
    ..Tract-specific microstructural changes may aid in better understanding the mechanism of cognitive impairment and neurodegenerative diseases. ..
  21. doi request reprint Changes in normal-appearing white matter precede development of white matter lesions
    Marius de Groot
    Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Stroke 44:1037-42. 2013
    ..We therefore investigated whether development of WML is preceded by quantifiable changes in normal-appearing white matter (NAWM)...
  22. doi request reprint Rating method for dilated Virchow-Robin spaces on magnetic resonance imaging
    Hieab H H Adams
    Department of Epidemiology, Erasmus MC, Dr Molewaterplein 50, 3015GE Rotterdam, The Netherlands
    Stroke 44:1732-5. 2013
    ..Dilated Virchow-Robin spaces are an emerging neuroimaging biomarker, but their assessment on MRI needs standardization...
  23. doi request reprint Brain cortical thickness in the general elderly population: the Rotterdam Scan Study
    Evert F S van Velsen
    Department of Epidemiology, Erasmus Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Neurosci Lett 550:189-94. 2013
    ..Additionally, higher education, higher diastolic blood pressure and larger intra-cranial volume were related to a larger cortical thickness, whilst diabetes mellitus and higher HDL cholesterol levels were related to a thinner cortex. ..
  24. doi request reprint Cerebral microbleeds are related to loss of white matter structural integrity
    Saloua Akoudad
    From the Departments of Epidemiology S A, M D G, A H, M A I, M W V, Radiology S A, M D G, A v d L, W J N, M A I, M W V, Neurology S A, P J K, M A I, and Medical Informatics M d G, W J N, Erasmus MC, University Medical Center Rotterdam and Imaging Science and Technology W J N, Faculty of Applied Sciences, Delft University of Technology, The Netherlands
    Neurology 81:1930-7. 2013
    ..To investigate whether the presence of cerebral microbleeds, which present as focal lesions on imaging, is associated with a diffuse loss of white matter microstructural integrity in the brain...
  25. doi request reprint Statistical analysis of minimum cost path based structural brain connectivity
    Renske de Boer
    Biomedical Imaging Group Rotterdam, Department of Radiology, Erasmus MC, Rotterdam, The Netherlands
    Neuroimage 55:557-65. 2011
    ....
  26. doi request reprint Brain tissue volumes in relation to cognitive function and risk of dementia
    M Arfan Ikram
    Department of Epidemiology, Erasmus MC University Medical Center, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Neurobiol Aging 31:378-86. 2010
    ....
  27. doi request reprint White matter lesion extension to automatic brain tissue segmentation on MRI
    Renske de Boer
    Biomedical Imaging Group Rotterdam, Departments of Radiology and Medical Informatics, Erasmus MC, Rotterdam, The Netherlands
    Neuroimage 45:1151-61. 2009
    ..The results indicated that the automatic segmentation accuracy is close to the interobserver variability of manual segmentations...
  28. doi request reprint High blood pressure and cerebral white matter lesion progression in the general population
    Benjamin F J Verhaaren
    Department of Epidemiology, Erasmus MC University Medical Center, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Hypertension 61:1354-9. 2013
    ..12 [0.00; 0.23] mL/y). The present study further establishes high blood pressure to precede WMLs and implies that hypertension treatment could reduce WML progression in the general population...
  29. ncbi request reprint Iterative co-linearity filtering and parameterization of fiber tracts in the entire cingulum
    Marius de Groot
    Biomedical Imaging Group Rotterdam, Department of Radiology, Erasmus MC, Rotterdam, The Netherlands
    Med Image Comput Comput Assist Interv 12:853-60. 2009
    ..Our asymmetry analysis shows a higher fractional anisotropy in the left anterior part of the cingulum compared to the right side, and the opposite effect in the posterior part...
  30. doi request reprint Intracranial carotid artery atherosclerosis: prevalence and risk factors in the general population
    Daniel Bos
    Department of Radiology, Erasmus MC, PO Box 2040, 3000CA Rotterdam, The Netherlands
    Stroke 43:1878-84. 2012
    ..In this study, we determined the prevalence and investigated risk factors of intracranial internal carotid artery calcification (ICAC) as a marker of intracranial atherosclerosis...
  31. doi request reprint Vascular brain disease and depression in the elderly
    M Arfan Ikram
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Epidemiology 21:78-81. 2010
    ..Cross-sectional studies have shown an association between vascular brain disease and depression. Longitudinal data are scarce. In a population-based study we investigated this relationship both cross-sectionally and longitudinally...
  32. doi request reprint Lobar distribution of cerebral microbleeds: the Rotterdam Scan Study
    Dymph J Mesker
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Arch Neurol 68:656-9. 2011
    ..To investigate the distribution of lobar microbleeds over the different lobes, taking into account lobar volume and clustering effects of multiple microbleeds...
  33. doi request reprint Prevalence and risk factors of cerebral microbleeds: an update of the Rotterdam scan study
    Mariëlle M F Poels
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Stroke 41:S103-6. 2010
    ..We examined the prevalence and determinants of microbleeds in this larger and younger cohort from the general population...
  34. doi request reprint Accuracy and reproducibility study of automatic MRI brain tissue segmentation methods
    Renske de Boer
    Department of Radiology and Medical Informatics, Erasmus MC, Rotterdam, The Netherlands
    Neuroimage 51:1047-56. 2010
    ..Example sample size calculations demonstrate a rather large effect of the choice of segmentation method on the required number of subjects...
  35. doi request reprint Carotid Atherosclerotic Plaque Characteristics on Magnetic Resonance Imaging Relate With History of Stroke and Coronary Heart Disease
    Mariana Selwaness
    From the Departments of Epidemiology M S, D B, Q v d B, M L P P, M A I, A H, O H F, M W V, Radiology D B, Q v d B, M A I, A v d L, M W V, and Neurology M A I, Erasmus MC, Rotterdam, the Netherlands and Department of Cardiology, Biomedical Engineering, Erasmus MC, Rotterdam, The Netherlands J J W
    Stroke 47:1542-7. 2016
    ..We examined whether carotid atherosclerotic wall thickness, stenosis, and plaque composition are related to history of ischemic stroke and coronary heart disease (CHD)...
  36. doi request reprint Fine-mapping the effects of Alzheimer's disease risk loci on brain morphology
    Gennady V Roshchupkin
    Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands Department of Medical Informatics, Erasmus MC, Rotterdam, The Netherlands
    Neurobiol Aging 48:204-211. 2016
    ..nl/ADSNPs/. In this single largest imaging genetics data set worldwide, we found that AD risk loci affect cortical gray matter in several brain regions known to be involved in AD, as well as regions that have not been implicated before...
  37. doi request reprint Lower microstructural integrity of brain white matter is related to higher mortality
    Sanaz Sedaghat
    From the Departments of Epidemiology S S, L G M C, M D G, A H, O H F, A D, M A I, M W V, Radiology L G M C, M D G, A v d L, W J N, M A I, M W V, Medical informatics M d G, W J N, and Neurology M A I, Erasmus University Medical Center, Rotterdam and Imaging Science and Technology W J N, Faculty of Applied Sciences, Delft University of Technology, The Netherlands
    Neurology 87:927-34. 2016
    ..To investigate the association of cerebral white matter microstructural integrity with mortality...
  38. doi request reprint TMEM106B influences volume of left-sided temporal lobe and interhemispheric structures in the general population
    Hieab H H Adams
    Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands Department of Radiology, Erasmus MC, Rotterdam, The Netherlands
    Biol Psychiatry 76:503-8. 2014
    ..The TMEM106B rs1990622 polymorphism is associated with frontotemporal lobar degeneration, but little is known about how it affects the brain...
  39. doi request reprint Incidence of cerebral microbleeds in the general population: the Rotterdam Scan Study
    Mariëlle M F Poels
    Department of Radiology, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Stroke 42:656-61. 2011
    ..Cerebral microbleeds are frequently seen in the general elderly population, but it is unknown at what rate they occur with aging and whether once present can disappear over time...
  40. doi request reprint Total cerebral blood flow in relation to cognitive function: the Rotterdam Scan Study
    Mariëlle M F Poels
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    J Cereb Blood Flow Metab 28:1652-5. 2008
    ..However, after correcting tCBF for brain volume, these associations disappeared. The association between tCBF and cognition may be mediated or confounded by brain atrophy. Future studies on tCBF should take into account brain atrophy...
  41. doi request reprint Use of coumarin anticoagulants and cerebral microbleeds in the general population
    Saloua Akoudad
    From the Departments of Epidemiology S A, S K L D, M J G L, A H, B H S, M A I, M W V, Radiology S A, A v d L, M A I, M W V, Neurology S A, P J K, M A I, and Cardiology M J G L, Erasmus MC, Rotterdam, the Netherlands and Inspectorate of Health Care, The Hague, the Netherlands B H S
    Stroke 45:3436-9. 2014
    ....
  42. doi request reprint Tract-specific white matter microstructure and gait in humans
    Vincentius J A Verlinden
    Department of Epidemiology, Erasmus University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Neurobiol Aging 43:164-73. 2016
    ..Our findings suggest that intact thalamocortical communication, cortex-to-cortex communication, and interhemispheric visuospatial integration are most essential in human gait. ..
  43. pmc The Rotterdam Study: 2016 objectives and design update
    Albert Hofman
    Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Epidemiol 30:661-708. 2015
    ..erasmus-epidemiology.nl/rotterdamstudy ). This article gives the rationale of the study and its design. It also presents a summary of the major findings and an update of the objectives and methods...
  44. doi request reprint Heritability and Genome-Wide Association Analyses of Intracranial Carotid Artery Calcification: The Rotterdam Study
    Hieab H H Adams
    From the Departments of Epidemiology H H H A, M A I, M W V, A H, A G U, C M v D, O H F, D B, Radiology M A I, M W V, A C v D, A v d L, D B, Neurology M A I, A C v D, P J K, and Internal Medicine A G U, Erasmus MC, Rotterdam, The Netherlands and Department of Epidemiology, Harvard T H Chan School of Public Health, Boston, MA A H
    Stroke 47:912-7. 2016
    ..Intracranial carotid artery calcification (ICAC) is one of the most important risk factors for stroke. Although several environmental risk factors for ICAC have been identified, its genetic background remains unclear...
  45. doi request reprint Replication study of chr17q25 with cerebral white matter lesion volume
    Benjamin F J Verhaaren
    Department of Epidemiology, Erasmus MC University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Stroke 42:3297-9. 2011
    ..We report on the first independent replication study of this genetic association...
  46. doi request reprint Serum lipid levels and the risk of intracerebral hemorrhage: the Rotterdam Study
    Renske G Wieberdink
    Department of Epidemiology, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 31:2982-9. 2011
    ..We determined whether serum HDL-cholesterol, LDL-cholesterol, and triglycerides are associated with risk of intracerebral hemorrhage and presence of cerebral microbleeds...
  47. ncbi request reprint Kidney function is related to cerebral small vessel disease
    M Arfan Ikram
    Department of Epidemiology and Biostatistics, Erasmus MC, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Stroke 39:55-61. 2008
    ..We investigated this association in a population-based study of elderly persons...
  48. ncbi request reprint Brain tissue volumes and small vessel disease in relation to the risk of mortality
    M Arfan Ikram
    Department of Epidemiology and Biostatistics, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Neurobiol Aging 30:450-6. 2009
    ..Censoring at either incident dementia or stroke did not change the risk associated with brain atrophy and WML. Moreover, WML were particularly associated with cardiovascular mortality...
  49. doi request reprint Genetic risk of neurodegenerative diseases is associated with mild cognitive impairment and conversion to dementia
    Hieab H H Adams
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Alzheimers Dement 11:1277-85. 2015
    ..Genome-wide association studies have uncovered many genetic variants conferring risk of neurodegenerative diseases, but their role in cognitive impairment remains unexplored...
  50. doi request reprint Determinants of carotid atherosclerotic plaque burden in a stroke-free population
    Mariana Selwaness
    Department of Epidemiology, MC, Rotterdam, The Netherlands
    Atherosclerosis 255:186-192. 2016
    ..In a large stroke-free population, we sought to identify cardiovascular risk factors and carotid plaque components associated with carotid plaque burden, lumen volume and stenosis...
  51. ncbi request reprint N-Terminal Pro-B-Type Natriuretic Peptide and Subclinical Brain Damage in the General Population
    Hazel I Zonneveld
    From the Departments of Epidemiology H I Z, M A I, A H, O H F, M W V, Radiology and Nuclear Medicine H I Z, M A I, W J N, A v d L, G P K, M W V, Neurology M A I, and Medical Informatics W J N, Erasmus MC, University Medical Center Rotterdam, Room Na28 18, PO Box 2040, 3000 CA Rotterdam, The Netherlands Department of Epidemiology, Harvard T H Chan School of Public Health, Boston, Mass A H and Department of Imaging Physics, Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands W J N
    Radiology . 2016
    ..sup>© RSNA, 2016 Online supplemental material is available for this article...
  52. doi request reprint White matter lesions relate to tract-specific reductions in functional connectivity
    Carolyn D Langen
    Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands Department of Medical Informatics, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Neurobiol Aging 51:97-103. 2016
    ..These results suggest that local white matter lesions can decrease tract-specific functional connectivity, both in direct and indirect connections...
  53. ncbi request reprint White Matter Microstructure Improves Stroke Risk Prediction in the General Population
    Tavia E Evans
    From the Department of Epidemiology T E E, M D G, A H, M L P P, D B, M W V, M A I, Department of Radiology and Nuclear Medicine T E E, M D G, W J N, G P K, A v d L, D B, M W V, M A I, Department of Medical Informatics M d G, W J N, and Department of Neurology M L P P, P J K, M A I, Erasmus MC, Rotterdam, The Netherlands Department of Basic and Clinical Neurosciences, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, United Kingdom T E E, M J O Imaging Physics, Faculty of Applied Sciences, Delft University of Technology, The Netherlands W J N and Department of Epidemiology, Harvard T H Chan School of Public Health, Boston, MA A H, Department of Developmental Biology
    Stroke 47:2756-2762. 2016
    ..White matter microstructural integrity is considered an earlier, potentially better, marker of the total burden of vascular brain disease. Its association with risk of stroke, a focal event, remains unknown...
  54. ncbi request reprint Thyroid function and the risk of dementia: The Rotterdam Study
    Layal Chaker
    From the Rotterdam Thyroid Center L C, T I M K, R P P and Departments of Internal Medicine L C, T I M K, R P P, Epidemiology L C, F J W, D B, T I M K, A H, O H F, A D, M W V, R P P, M A I, Neurology F J W, P J K, M A I, and Radiology D B, A v d L, M W V, M A I, Erasmus University Medical Center, Rotterdam, the Netherlands and Department of Epidemiology A H, Harvard T H Chan School of Public Health, Boston, MA
    Neurology 87:1688-1695. 2016
    ..To study the role of thyroid function in dementia, cognitive function, and subclinical vascular brain disease with MRI...
  55. doi request reprint White Matter Degeneration with Aging: Longitudinal Diffusion MR Imaging Analysis
    Marius de Groot
    From the Departments of Radiology M d G, L G M C, M A I, G P K, A v d L, W J N, M W V, Medical informatics M d G, W J N, Epidemiology M d G, L G M C, M A I, A H, M W V, and Neurology M A I, Erasmus MC, University Medical Center Rotterdam, PO Box 2040, Room Ca220, 3000 CA Rotterdam, the Netherlands and Department of Imaging Science and Technology, Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands W J N
    Radiology 279:532-41. 2016
    ..To determine longitudinally the rate of change in diffusion-tensor imaging (DTI) parameters of white matter microstructure with aging and to investigate whether cardiovascular risk factors influence this longitudinal change...
  56. doi request reprint Comparison of Atherosclerotic Calcification in Major Vessel Beds on the Risk of All-Cause and Cause-Specific Mortality: The Rotterdam Study
    Daniel Bos
    From the Departments of Radiology D B, A L, M W V, M A I, Epidemiology D B, M J G L, M K, A H, O H F, M W V, M A I, Cardiology M J G L, and Neurology M A I, Erasmus MC, Rotterdam, The Netherlands
    Circ Cardiovasc Imaging 8:. 2015
    ..Atherosclerosis is a major contributor to global morbidity and mortality. Although atherosclerosis is a systemic disease, its burden varies considerably across vessel beds, which may translate into differences in mortality risk...
  57. doi request reprint Markers of cerebral small vessel disease and severity of depression in the general population
    Nese Direk
    Department of Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands
    Psychiatry Res 253:1-6. 2016
    ..Association of cerebral microbleeds with more severe forms of depression may indicate impaired brain iron homeostasis or minor episodes of cerebrovascular extraversion, which may play a role in depression etiology. ..
  58. pmc Clopidogrel use is associated with an increased prevalence of cerebral microbleeds in a stroke-free population: the Rotterdam study
    Sirwan K L Darweesh
    Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Am Heart Assoc 2:e000359. 2013
    ..We examined the association between use of clopidogrel and CMBs in persons without a history of stroke...
  59. pmc The Rotterdam Scan Study: design update 2016 and main findings
    M Arfan Ikram
    Department of Epidemiology, Erasmus MC University Medical Center, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Epidemiol 30:1299-315. 2015
    ..Finally, we provide recommendations for future research, which will also be topics of investigation in the Rotterdam Scan Study. ..
  60. doi request reprint Genetic Determinants of Unruptured Intracranial Aneurysms in the General Population
    Abbas Peymani
    From the Departments of Epidemiology A P, H H H A, L G M C, A H, C M v D, A G U, M W V, M A I, Neurology M A I, Radiology H H H A, L G M C, G K, A v d L, M W V, M A I, and Internal Medicine A G U, Erasmus University Medical Center, Rotterdam, The Netherlands
    Stroke 46:2961-4. 2015
    ..We studied the role of these genetic variants on occurrence and size of unruptured intracranial aneurysms, discovered incidentally in a general community-dwelling population...
  61. doi request reprint Coexistence of Calcification, Intraplaque Hemorrhage and Lipid Core within the Asymptomatic Atherosclerotic Carotid Plaque: The Rotterdam Study
    Quirijn J A van den Bouwhuijsen
    Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands
    Cerebrovasc Dis 39:319-24. 2015
    ..Therefore, in this study we set out to investigate the coexistence of intraplaque calcification, hemorrhage and lipid core within the carotid artery using a multi-modality imaging approach...
  62. doi request reprint Atherosclerotic calcification is related to a higher risk of dementia and cognitive decline
    Daniel Bos
    Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Alzheimers Dement 11:639-47.e1. 2015
    ..Longitudinal data on the role of atherosclerosis in different vessel beds in the etiology of cognitive impairment and dementia are scarce and inconsistent...
  63. doi request reprint Kidney function and microstructural integrity of brain white matter
    Sanaz Sedaghat
    From the Departments of Epidemiology S S, L G M C, M D G, A H, O H F, M W V, A D, M A I, Radiology L G M C, M D G, A v d L, M W V, M A I, Medical informatics M d G, Internal Medicine E J H, and Neurology M A I, Erasmus University Medical Center, Rotterdam, The Netherlands
    Neurology 85:154-61. 2015
    ..To investigate the association of kidney function with white matter microstructural integrity...
  64. doi request reprint Tract-specific white matter degeneration in aging: the Rotterdam Study
    Marius de Groot
    Department of Radiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands Department of Medical Informatics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Alzheimers Dement 11:321-30. 2015
    ..Loss of brain white matter microstructure is presumed to be an early sign of neurodegenerative disease. Yet, little is known on microstructural changes of various white matter tracts with normal aging...
  65. doi request reprint Cerebral microbleeds: accelerated 3D T2*-weighted GRE MR imaging versus conventional 2D T2*-weighted GRE MR imaging for detection
    Meike W Vernooij
    Department of Epidemiology and Biostatistics, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Radiology 248:272-7. 2008
    ..In conclusion, accelerated 3D T2*-weighted GRE images depict more microbleeds than do conventional 2D T2*-weighted GRE images...
  66. ncbi request reprint Incidental findings on brain MRI in the general population
    Meike W Vernooij
    Department of Epidemiology and Biostatistics, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    N Engl J Med 357:1821-8. 2007
    ..We conducted a study to determine the prevalence of such incidental brain findings in the general population...
  67. doi request reprint Kidney function and cerebral small vessel disease in the general population
    Saloua Akoudad
    Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Int J Stroke 10:603-8. 2015
    ..Although several distinct markers are used to identify subclinical kidney and brain disease, a comprehensive assessment of how these markers link damage at both end organs is lacking...
  68. doi request reprint Determinants, MRI correlates, and prognosis of mild cognitive impairment: the Rotterdam Study
    Renée F A G de Bruijn
    Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Alzheimers Dis 42:S239-49. 2014
    ..Participants with MCI had an increased risk of dementia, including Alzheimer's disease, and mortality. ..
  69. doi request reprint Cerebral Microbleeds Are Associated With an Increased Risk of Stroke: The Rotterdam Study
    Saloua Akoudad
    From Departments of Epidemiology S A, M L P P, A H, M A I, M W V, Radiology S A, A v d L, M A I, M W V, and Neurology S A, M L P P, P J K, M A I, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Circulation 132:509-16. 2015
    ..Microbleeds are also frequently found in healthy elderly, a population in which the clinical implication of microbleeds is unknown...
  70. pmc Cerebral microbleeds are associated with the progression of ischemic vascular lesions
    Saloua Akoudad
    Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Cerebrovasc Dis 37:382-8. 2014
    ..We therefore aimed to investigate whether pre-existing and incident cerebral microbleeds (CMBs) are related to the progression of ischemic lesions in the general population...
  71. doi request reprint Improving alignment in Tract-based spatial statistics: evaluation and optimization of image registration
    Marius de Groot
    Department of Radiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Neuroimage 76:400-11. 2013
    ..At optimal parameters, both algorithms outperformed the registration of TBSS, showing feasibility of adopting such approaches in TBSS. This was further confirmed in the example experiment...
  72. doi request reprint Apolipoprotein E genotype influences spatial distribution of cerebral microbleeds
    Elizabeth Loehrer
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands Netherlands Institute for Health Sciences, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Neurobiol Aging 35:899-905. 2014
    ..Similar to cerebral amyloid angiopathy patients, microbleeds in the general population cluster and the distribution is affected by APOE genotype...
  73. ncbi request reprint Total cerebral blood flow and total brain perfusion in the general population: the Rotterdam Scan Study
    Meike W Vernooij
    Department of Epidemiology and Biostatistics, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    J Cereb Blood Flow Metab 28:412-9. 2008
    ..Prospective studies are required to unravel whether hypoperfusion contributes to WML formation or that tissue damage, manifested by WML, leads to brain hypoperfusion...
  74. ncbi request reprint Arteriolar oxygen saturation, cerebral blood flow, and retinal vessel diameters. The Rotterdam Study
    Frank Jan de Jong
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, Netherlands Department of Neurology, Erasmus Medical Center, Rotterdam, Netherlands
    Ophthalmology 115:887-92. 2008
    ..The authors investigated whether arteriolar oxygen saturation (SaO2) and total cerebral blood flow (CBF), indicators of cerebral oxygen supply, are associated with retinal arteriolar or venular diameters...
  75. doi request reprint Calcification in major vessel beds relates to vascular brain disease
    Daniel Bos
    Department of Radiology, Erasmus MC, Rotterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 31:2331-7. 2011
    ..However, its relationship with cerebrovascular disease has not been investigated extensively. We investigated the relationship between calcification in various vessel beds outside the brain and imaging markers of vascular brain disease...
  76. pmc Microstructural brain injury in post-concussion syndrome after minor head injury
    Marion Smits
    Department of Radiology Hs 224, Erasmus MC University Medical Centre Rotterdam, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Neuroradiology 53:553-63. 2011
    ....
  77. ncbi request reprint Multi-spectral brain tissue segmentation using automatically trained k-Nearest-Neighbor classification
    Henri A Vrooman
    Department of Radiology, Erasmus MC, P O Box 1738, Rotterdam, The Netherlands
    Neuroimage 37:71-81. 2007
    ..It can be concluded that our fully automated method using non-rigid registration may replace manual segmentation, and thus that automated brain tissue segmentation without laborious manual training is feasible...
  78. doi request reprint Automated measurement of local white matter lesion volume
    Fedde van der Lijn
    Department of Medical Informatics, Erasmus MC, Rotterdam, The Netherlands
    Neuroimage 59:3901-8. 2012
    ..But the proposed method can localize the region of association with greater precision than techniques that distinguish between periventricular and subcortical lesions only...
  79. doi request reprint Determinants of magnetic resonance imaging detected carotid plaque components: the Rotterdam Study
    Quirijn J A van den Bouwhuijsen
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Eur Heart J 33:221-9. 2012
    ..The association between plaque components and risk factors for cardiovascular disease is not well studied...
  80. pmc The bidirectional association between reduced cerebral blood flow and brain atrophy in the general population
    Hazel I Zonneveld
    Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Cereb Blood Flow Metab 35:1882-7. 2015
    ..036) in those aged ⩾65 years of age). Our results indicate that brain atrophy causes CBF to decrease over time, rather than vice versa. Only in persons aged >65 years of age did we find lower CBF to also relate to brain atrophy. ..
  81. doi request reprint Epicardial fat volume is related to atherosclerotic calcification in multiple vessel beds
    Daniel Bos
    Department of Radiology, Erasmus MC, PO Box 2040, Rotterdam 3000CA, The Netherlands Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands
    Eur Heart J Cardiovasc Imaging 16:1264-9. 2015
    ..To investigate relationships between epicardial fat volume and atherosclerosis in multiple major vessel beds...
  82. doi request reprint The role of cerebellar volume in cognition in the general elderly population
    Yoo Young Hoogendam
    Departments of Epidemiology Radiology Neuroscience Medical Informatics Neurology, Erasmus MC University Medical Center, Rotterdam Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands
    Alzheimer Dis Assoc Disord 28:352-7. 2014
    ..In a population-based study on 3745 nondemented individuals aged 45 years and above, we investigated the relationship between cerebellar volume and cognitive function...
  83. doi request reprint Left-sided strokes are more often recognized than right-sided strokes: the Rotterdam study
    Marileen L P Portegies
    From the Department of Epidemiology M L P P, M S, A H, M W V, M A I, Neurology M L P P, P J K, M A I, Biomedical Engineering M S, and Radiology M S, M W V, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Stroke 46:252-4. 2015
    ..In a large unselected community-dwelling population, we examined the frequency of clinical left- and right-sided strokes and transient ischemic attacks (TIAs) and compared it with the frequency of left- and right-sided infarcts on MRI...
  84. doi request reprint Hippocampal shape is predictive for the development of dementia in a normal, elderly population
    Hakim C Achterberg
    Biomedical Imaging Group Rotterdam, Departments of Radiology and Medical Informatics, Erasmus MC, Rotterdam, The Netherlands
    Hum Brain Mapp 35:2359-71. 2014
    ..Furthermore, the results suggest that hippocampal shape provides additional predictive value over hippocampal volume and that combining shape and volume leads to better prediction...
  85. pmc The thyroid hormone receptor alpha locus and white matter lesions: a role for the clock gene REV-ERBα
    Marco Medici
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Thyroid 22:1181-6. 2012
    ..We therefore studied genetic variation in the TRα/REV-ERBα locus in relation to brain imaging data, as early markers for small vessel disease and neurodegeneration...
  86. pmc The Rotterdam Study: 2012 objectives and design update
    Albert Hofman
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Epidemiol 26:657-86. 2011
    ..erasmus-epidemiology.nl/rotterdamstudy ). This article gives the rationale of the study and its design. It also presents a summary of the major findings and an update of the objectives and methods...
  87. pmc Genome-wide profiling of blood pressure in adults and children
    Hendrik R Taal
    The Generation R Study Group AE 006, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Hypertension 59:241-7. 2012
    ....
  88. doi request reprint Migraine and cerebral blood flow in the general population
    Elizabeth Loehrer
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Cephalalgia 35:190-8. 2015
    ..In a population-based setting, we compared cerebral blood flow between migraineurs in the attack-free period and controls...
  89. doi request reprint Cerebral small vessel disease affects white matter microstructure in mild cognitive impairment
    Janne M Papma
    Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Hum Brain Mapp 35:2836-51. 2014
    ..In conclusion, we found evidence of CSVD-related microstructural damage in fiber tracts subserving the DMN in MCI...
  90. pmc Common variants at 12q15 and 12q24 are associated with infant head circumference
    H Rob Taal
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Nat Genet 44:532-8. 2012
    ....
  91. doi request reprint Global and focal white matter integrity in breast cancer survivors 20 years after adjuvant chemotherapy
    Vincent Koppelmans
    Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands Department of Psychosocial Research and Epidemiology, Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    Hum Brain Mapp 35:889-99. 2014
    ....
  92. doi request reprint Silent brain infarcts: a cause of depression in the elderly?
    Heidi C Saavedra Perez
    Department of Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands
    Psychiatry Res 211:180-2. 2013
    ..Participants were followed up during 3.6 years to determine incident and recurrent depression. We found an increased risk of recurrent depression associated with silent brain infarcts...
  93. pmc Common variants at 6q22 and 17q21 are associated with intracranial volume
    M Arfan Ikram
    Department of Epidemiology, Erasmus Medical Center University Medical Center, Rotterdam, The Netherlands
    Nat Genet 44:539-44. 2012
    ..5 months). Our data identify two loci associated with head size, with the inversion at 17q21 also likely to be involved in attaining maximal brain size...
  94. ncbi request reprint Brain tissue volumes in the general elderly population. The Rotterdam Scan Study
    M Arfan Ikram
    Department of Epidemiology and Biostatistics, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Neurobiol Aging 29:882-90. 2008
    ..In the elderly, higher age, small vessel disease and cardiovascular risk factors are associated with smaller brain volume, especially WM volume...
  95. ncbi request reprint Incorporating functional MR imaging into diffusion tensor tractography in the preoperative assessment of the corticospinal tract in patients with brain tumors
    M Smits
    Department of Radiology, Erasmus MC, Rotterdam, The Netherlands
    AJNR Am J Neuroradiol 28:1354-61. 2007
    ..We investigated whether the integration of functional MR imaging (fMRI) data and diffusion tensor (DT) tractography can be used to evaluate the spatial relationship between the hand and foot fibers of the CST and tumor borders...