Ramin Vafadari

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. doi Inhibitory effect of tacrolimus on p38 mitogen-activated protein kinase signaling in kidney transplant recipients measured by whole-blood phosphospecific flow cytometry
    Ramin Vafadari
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Transplantation 93:1245-51. 2012
  2. doi Genetic polymorphisms in ABCB1 influence the pharmacodynamics of tacrolimus
    Ramin Vafadari
    Department of Internal Medicine, University Medical Center, Rotterdam, The Netherlands
    Ther Drug Monit 35:459-65. 2013
  3. pmc Phospho-specific flow cytometry for pharmacodynamic monitoring of immunosuppressive therapy in transplantation
    Carla Baan
    Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Transplant Res 1:20. 2012
  4. doi Pharmacodynamic analysis of tofacitinib and basiliximab in kidney allograft recipients
    Ramin Vafadari
    Department of Internal Medicine, Erasmus Medical Center, University Hospital Rotterdam, Rotterdam, The Netherlands
    Transplantation 94:465-72. 2012
  5. doi Phosphospecific flow cytometry for pharmacodynamic drug monitoring: analysis of the JAK-STAT signaling pathway
    Ramin Vafadari
    Department of Internal Medicine, Erasmus MC, University medical Hospital Rotterdam, The Netherlands
    Clin Chim Acta 413:1398-405. 2012
  6. pmc Tacrolimus inhibits NF-κB activation in peripheral human T cells
    Ramin Vafadari
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    PLoS ONE 8:e60784. 2013
  7. doi Conversion to Once-Daily Tacrolimus Results in Increased p38MAPK Phosphorylation in T Lymphocytes of Kidney Transplant Recipients
    Nynke M Kannegieter
    Department of Internal Medicine, Division of Nephrology and Transplantation and Department of Hospital Pharmacy, Clinical Pharmacology Unit, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Ther Drug Monit 38:280-4. 2016

Collaborators

Detail Information

Publications7

  1. doi Inhibitory effect of tacrolimus on p38 mitogen-activated protein kinase signaling in kidney transplant recipients measured by whole-blood phosphospecific flow cytometry
    Ramin Vafadari
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Transplantation 93:1245-51. 2012
    ..We studied whether TAC inhibits p38 MAPK signaling in primary human T cells and ex vivo in healthy volunteers and kidney transplant recipients...
  2. doi Genetic polymorphisms in ABCB1 influence the pharmacodynamics of tacrolimus
    Ramin Vafadari
    Department of Internal Medicine, University Medical Center, Rotterdam, The Netherlands
    Ther Drug Monit 35:459-65. 2013
    ..Here the influence of this SNP on the biological effect of tacrolimus was studied...
  3. pmc Phospho-specific flow cytometry for pharmacodynamic monitoring of immunosuppressive therapy in transplantation
    Carla Baan
    Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Transplant Res 1:20. 2012
    ..Through this tool the efficacy of immunosuppressive medication can be assessed, novel targets can be identified, and differences in drug sensitivity between cells and patients can be clarified...
  4. doi Pharmacodynamic analysis of tofacitinib and basiliximab in kidney allograft recipients
    Ramin Vafadari
    Department of Internal Medicine, Erasmus Medical Center, University Hospital Rotterdam, Rotterdam, The Netherlands
    Transplantation 94:465-72. 2012
    ..We investigated the effect of immunosuppressive drugs targeting this pathway, the JAK inhibitor tofacitinib (CP-690,550) and the anti-interleukin (IL)-2R antibody basiliximab, as part of a phase 2 study...
  5. doi Phosphospecific flow cytometry for pharmacodynamic drug monitoring: analysis of the JAK-STAT signaling pathway
    Ramin Vafadari
    Department of Internal Medicine, Erasmus MC, University medical Hospital Rotterdam, The Netherlands
    Clin Chim Acta 413:1398-405. 2012
    ....
  6. pmc Tacrolimus inhibits NF-κB activation in peripheral human T cells
    Ramin Vafadari
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    PLoS ONE 8:e60784. 2013
    ..p<0.01 vs. no drug), confirming impaired NF-κB signaling. This study shows the suppressive effect of TAC on NF-κB signaling in peripheral human T cell subsets, measured at three specific positions in the NF-κB activation cascade...
  7. doi Conversion to Once-Daily Tacrolimus Results in Increased p38MAPK Phosphorylation in T Lymphocytes of Kidney Transplant Recipients
    Nynke M Kannegieter
    Department of Internal Medicine, Division of Nephrology and Transplantation and Department of Hospital Pharmacy, Clinical Pharmacology Unit, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Ther Drug Monit 38:280-4. 2016
    ..As an additional tool in transplantation diagnostics, phospho-specific flow cytometry was used to study the biological effects of conversion on p38MAPK phosphorylation, a kinase involved in T-lymphocyte activation...