Andre G Uitterlinden

Summary

Affiliation: Erasmus University
Country: The Netherlands

Publications

  1. ncbi The Asp727Glu polymorphism in the TSH receptor is associated with insulin resistance in healthy elderly men
    Robin P Peeters
    Department of Internal Medicine, Erasmus University Medical Cetnre, Rotterdam, The Netherlands
    Clin Endocrinol (Oxf) 66:808-15. 2007
  2. ncbi The role of vitamin D receptor gene polymorphisms in bone biology
    Andre G Uitterlinden
    Genomic Laboratory Room Ee575, Department of Internal Medicine, Erasmus University Medical School, Dr Molewaterplein 50, PO Box 1738, GD 3015 Rotterdam, The Netherlands
    Mol Cell Endocrinol 197:15-21. 2002
  3. ncbi A polymorphism in the AMH type II receptor gene is associated with age at menopause in interaction with parity
    Marlies E Kevenaar
    Department of Internal Medicine, Room Ee532, PO Box 2040, Erasmus MC, 3000 CA Rotterdam, The Netherlands
    Hum Reprod 22:2382-8. 2007
  4. ncbi Polymorphic variations in exon 10 of the luteinizing hormone receptor: functional consequences and associations with breast cancer
    Djura Piersma
    Department of Internal Medicine, Erasmus MC, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Mol Cell Endocrinol 276:63-70. 2007
  5. pmc Vitamin D binding protein genotype and osteoporosis
    Yue Fang
    Department of Internal Medicine, Erasmus Medical Center, Genetic Laboratory, Rotterdam, The Netherlands
    Calcif Tissue Int 85:85-93. 2009
  6. ncbi Estrogen receptor beta (ESR2) polymorphisms in interaction with estrogen receptor alpha (ESR1) and insulin-like growth factor I (IGF1) variants influence the risk of fracture in postmenopausal women
    Fernando Rivadeneira
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Bone Miner Res 21:1443-56. 2006
  7. pmc The role of body mass index, insulin, and adiponectin in the relation between fat distribution and bone mineral density
    M Carola Zillikens
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Calcif Tissue Int 86:116-25. 2010
  8. doi SIRT1 genetic variation and mortality in type 2 diabetes: interaction with smoking and dietary niacin
    M Carola Zillikens
    Department of Internal Medicine, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    Free Radic Biol Med 46:836-41. 2009
  9. ncbi The catechol-O-methyltransferase Met158 low-activity allele and association with nonvertebral fracture risk in elderly men
    Lisette Stolk
    Department of Internal Medicine, Erasmus Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    J Clin Endocrinol Metab 92:3206-12. 2007
  10. pmc SIRT1 genetic variation is related to BMI and risk of obesity
    M Carola Zillikens
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Diabetes 58:2828-34. 2009

Detail Information

Publications80

  1. ncbi The Asp727Glu polymorphism in the TSH receptor is associated with insulin resistance in healthy elderly men
    Robin P Peeters
    Department of Internal Medicine, Erasmus University Medical Cetnre, Rotterdam, The Netherlands
    Clin Endocrinol (Oxf) 66:808-15. 2007
    ..In addition, we analysed the Thr92Ala polymorphism in the type 2 deiodinase (D2), which was recently associated with insulin resistance...
  2. ncbi The role of vitamin D receptor gene polymorphisms in bone biology
    Andre G Uitterlinden
    Genomic Laboratory Room Ee575, Department of Internal Medicine, Erasmus University Medical School, Dr Molewaterplein 50, PO Box 1738, GD 3015 Rotterdam, The Netherlands
    Mol Cell Endocrinol 197:15-21. 2002
    ..The ultimate goal of this approach is to identify the combinations of functional sequence variants that modulate the vitamin D endocrine system and confer risk of disease...
  3. ncbi A polymorphism in the AMH type II receptor gene is associated with age at menopause in interaction with parity
    Marlies E Kevenaar
    Department of Internal Medicine, Room Ee532, PO Box 2040, Erasmus MC, 3000 CA Rotterdam, The Netherlands
    Hum Reprod 22:2382-8. 2007
    ..Since age at menopause has a strong genetic component, we investigated the role of AMH signaling using a candidate gene approach...
  4. ncbi Polymorphic variations in exon 10 of the luteinizing hormone receptor: functional consequences and associations with breast cancer
    Djura Piersma
    Department of Internal Medicine, Erasmus MC, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Mol Cell Endocrinol 276:63-70. 2007
    ..In conclusion, although functional changes of the LHR 291Ser candidate allele were observed, no associations with breast cancer were found, while the LHR 312Asn allele can be regarded as a weak breast cancer risk allele...
  5. pmc Vitamin D binding protein genotype and osteoporosis
    Yue Fang
    Department of Internal Medicine, Erasmus Medical Center, Genetic Laboratory, Rotterdam, The Netherlands
    Calcif Tissue Int 85:85-93. 2009
    ..05). All associations were independent of age and gender. Our study demonstrated that the genetic effect of the DBP gene on fracture risk appears only in combination with other genetic and environmental risk factors for bone metabolism...
  6. ncbi Estrogen receptor beta (ESR2) polymorphisms in interaction with estrogen receptor alpha (ESR1) and insulin-like growth factor I (IGF1) variants influence the risk of fracture in postmenopausal women
    Fernando Rivadeneira
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Bone Miner Res 21:1443-56. 2006
    ..Interaction of ESR2 with ESR1 and IGF1 was determined and revealed a deleterious genetic combination that enhances the risk of osteoporotic fracture...
  7. pmc The role of body mass index, insulin, and adiponectin in the relation between fat distribution and bone mineral density
    M Carola Zillikens
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Calcif Tissue Int 86:116-25. 2010
    ..Inverse associations after adjustment for BMI suggest that android fat deposition as measured by the WHR, WTR, and DXA-based android-to-gynoid fat ratio is not beneficial and possibly even deleterious for bone...
  8. doi SIRT1 genetic variation and mortality in type 2 diabetes: interaction with smoking and dietary niacin
    M Carola Zillikens
    Department of Internal Medicine, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    Free Radic Biol Med 46:836-41. 2009
    ..Correction of niacin deficiency and SIRT1 modulators may prolong the life span of patients with diabetes...
  9. ncbi The catechol-O-methyltransferase Met158 low-activity allele and association with nonvertebral fracture risk in elderly men
    Lisette Stolk
    Department of Internal Medicine, Erasmus Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    J Clin Endocrinol Metab 92:3206-12. 2007
    ..An example is catechol-O-methyltransferase (COMT), an estrogen-degrading enzyme involved in inactivation of catechol-estrogens. Its gene contains a functional valine to methionine substitution at codon 158...
  10. pmc SIRT1 genetic variation is related to BMI and risk of obesity
    M Carola Zillikens
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Diabetes 58:2828-34. 2009
    ..SIRT1 has pleiotropic metabolic functions. We investigated whether SIRT1 genetic variation is associated with obesity...
  11. ncbi ApoE gene polymorphisms, BMD, and fracture risk in elderly men and women: the Rotterdam study
    Mariette W C J Schoofs
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam 300 DR, The Netherlands
    J Bone Miner Res 19:1490-6. 2004
    ..We did not observe an association between the ApoE polymorphism and osteoporosis in this study, which is thus far the largest study on ApoE and osteoporosis...
  12. ncbi Height in pre- and postmenopausal women is influenced by estrogen receptor alpha gene polymorphisms
    Stephanie C E Schuit
    Department of Internal Medicine, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands
    J Clin Endocrinol Metab 89:303-9. 2004
    ..5 cm shorter per allele copy of the ESR1 haplotype 1 (P for trend = 0.03). In conclusion, we demonstrate a role for genetic variations in the estrogen receptor alpha gene in determining adult stature in women...
  13. doi Glucocorticoid receptor gene and risk of cardiovascular disease
    Erica L T Van Den Akker
    Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Arch Intern Med 168:33-9. 2008
    ..Our aim was to determine the contribution of genetic glucocorticoid receptor variants, with different cortisol sensitivities, to the risk of cardiovascular disease...
  14. ncbi Low dietary riboflavin but not folate predicts increased fracture risk in postmenopausal women homozygous for the MTHFR 677 T allele
    Nahid Yazdanpanah
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Bone Miner Res 23:86-94. 2008
    ..We found that the MTHFR C677T variant interacts with dietary riboflavin intake to influence fracture risk in women...
  15. doi Serum C reactive protein levels and genetic variation in the CRP gene are not associated with the prevalence, incidence or progression of osteoarthritis independent of body mass index
    Hanneke J M Kerkhof
    Department of Internal Medicine, Erasmus Medical Center Rotterdam, The Netherlands
    Ann Rheum Dis 69:1976-82. 2010
    ..A systematic review of studies assessing the relationship between osteoarthritis (OA) and CRP levels was also performed...
  16. doi Impact of thyroid function and polymorphisms in the type 2 deiodinase on blood pressure: the Rotterdam Study and the Rotterdam Scan Study
    Wendy M van der Deure
    Department of Internal Medicine, Erasmus University Medical Center Rotterdam, The Netherlands
    Clin Endocrinol (Oxf) 71:137-44. 2009
    ..However studies conducted thus far were small with controversial results...
  17. pmc Polymorphisms in the sclerosteosis/van Buchem disease gene (SOST) region are associated with bone-mineral density in elderly whites
    Andre G Uitterlinden
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Hum Genet 75:1032-45. 2004
    ..02). The molecular mechanism whereby these moderate SOST genotype effects are mediated remains to be elucidated, but it is likely to involve differences in regulation of SOST gene expression...
  18. pmc Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture
    Karol Estrada
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Nat Genet 44:491-501. 2012
    ..3 (SLC25A13), 11q13.2 (LRP5), 4q22.1 (MEPE), 2p16.2 (SPTBN1) and 10q21.1 (DKK1). These findings shed light on the genetic architecture and pathophysiological mechanisms underlying BMD variation and fracture susceptibility...
  19. doi Interactions between dietary vitamin E intake and SIRT1 genetic variation influence body mass index
    M Carola Zillikens
    Department of Internal Medicine, Room D428, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Am J Clin Nutr 91:1387-93. 2010
    ..Genetic variation in SIRT1 has been associated with body mass index (BMI) and risk of obesity. SIRT1 may be influenced by diet...
  20. ncbi Vitamin D receptor gene haplotype is associated with body height and bone size
    Yue Fang
    Genetic Laboratory, Room Ee575, Department of Internal Medicine, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    J Clin Endocrinol Metab 92:1491-501. 2007
    ..We recently identified promoter and 3'-untranslated region (UTR) haplotype alleles that influence vitamin D receptor (VDR) mRNA expression...
  21. ncbi Common genetic variation of the low-density lipoprotein receptor-related protein 5 and 6 genes determines fracture risk in elderly white men
    Joyce B J van Meurs
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Bone Miner Res 21:141-50. 2006
    ..LRP5 variation was associated to both BMD and frame size, whereas both LRP5 and 6 variations were associated with an increased fracture risk in males...
  22. doi The T-13910C polymorphism in the lactase phlorizin hydrolase gene is associated with differences in serum calcium levels and calcium intake
    W Nadia H Koek
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    J Bone Miner Res 25:1980-7. 2010
    ....
  23. ncbi Estrogen receptor alpha gene polymorphisms and risk of myocardial infarction
    Stephanie C E Schuit
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    JAMA 291:2969-77. 2004
    ..Evidence suggests that genetic variations in the estrogen receptor alpha (ESR1) gene may influence IHD risk, but the role of common sequence variations in the ESR1 gene is unclear...
  24. ncbi Effects of serum TSH and FT4 levels and the TSHR-Asp727Glu polymorphism on bone: the Rotterdam Study
    Wendy M van der Deure
    Department of Internal Medicine, Erasmus University Medical Centre, Rotterdam, The Netherlands
    Clin Endocrinol (Oxf) 68:175-81. 2008
    ..The TSHR-Asp727Glu polymorphism is associated with lower TSH levels. We therefore examined the association of this polymorphism with bone parameters...
  25. ncbi Estrogen receptor alpha gene polymorphisms are associated with estradiol levels in postmenopausal women
    Stephanie C E Schuit
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Endocrinol 153:327-34. 2005
    ..It has been suggested that the estrogen receptor alpha (ESR1) gene may influence peripheral E(2) levels, but the role of common sequence variations in the ESR1 gene is unclear...
  26. pmc Loci at chromosomes 13, 19 and 20 influence age at natural menopause
    Lisette Stolk
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    Nat Genet 41:645-7. 2009
    ..5 year per A allele (12%); P = 2.5 × 10(-8)). These common genetic variants regulate timing of ovarian aging, an important risk factor for breast cancer, osteoporosis and cardiovascular disease...
  27. doi A functional anti-mullerian hormone gene polymorphism is associated with follicle number and androgen levels in polycystic ovary syndrome patients
    Marlies E Kevenaar
    Department of Internal Medicine, Erasmus MC, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 93:1310-6. 2008
    ..In PCOS women, serum anti-Müllerian hormone (AMH) levels are elevated. Because AMH decreases FSH sensitivity in mice, the elevated AMH levels may contribute to the disturbed follicle selection in PCOS women...
  28. ncbi The RIZ Pro704 insertion-deletion polymorphism, bone mineral density and fracture risk: the Rotterdam study
    Lisette Stolk
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    Bone 42:286-93. 2008
    ..This suggests this polymorphism to play a minor role, if any, as a genetic determinant of osteoporosis in elderly subjects...
  29. doi Variants in the ACVR1 gene are associated with AMH levels in women with polycystic ovary syndrome
    Marlies E Kevenaar
    Department of Internal Medicine, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Hum Reprod 24:241-9. 2009
    ..Here, we investigated the role of ALK2, a type I receptor for AMH/BMP signalling, in PCOS using a genetic approach...
  30. pmc Promoter and 3'-untranslated-region haplotypes in the vitamin d receptor gene predispose to osteoporotic fracture: the rotterdam study
    Yue Fang
    Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands
    Am J Hum Genet 77:807-23. 2005
    ..This could impact the vitamin D signaling efficiency and might contribute to the increased fracture risk we observed for these risk haplotype alleles...
  31. pmc High bone mineral density and fracture risk in type 2 diabetes as skeletal complications of inadequate glucose control: the Rotterdam Study
    Ling Oei
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Diabetes Care 36:1619-28. 2013
    ..Individuals with type 2 diabetes have increased fracture risk despite higher bone mineral density (BMD). Our aim was to examine the influence of glucose control on skeletal complications...
  32. ncbi Vitamin D receptor gene BsmI and TaqI polymorphisms and fracture risk: a meta-analysis
    Yue Fang
    Department of Internal Medicine, Erasmus MC, 3015 GD Rotterdam, The Netherlands
    Bone 39:938-45. 2006
    ..The vitamin D receptor (VDR) gene is thought to be a candidate gene for osteoporosis. Many genetic studies have suggested an association of VDR polymorphisms and osteoporosis, but evidence remains conflicting...
  33. doi Organic anion transporter 1B1: an important factor in hepatic thyroid hormone and estrogen transport and metabolism
    Wendy M van der Deure
    Department of Internal Medicine, Erasmus University Medical Center, Room Ee 502, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Endocrinology 149:4695-701. 2008
    ..OATP1B1-Ala174 displays decreased transport activity and thereby gives rise to higher bilirubin, E1S, and T4S levels in carriers of this polymorphism...
  34. doi Determinants of maternal pregnancy one-carbon metabolism and newborn human DNA methylation profiles
    Nina H van Mil
    University Medical Centre Rotterdam, Dr Molewaterplein 50, 3015 GE Rotterdam, University Medical Centre Rotterdam, Dr Molewaterplein 50, 3015 GE Rotterdam, University Medical Centre Rotterdam, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Reproduction 148:581-92. 2014
    ..Research on the implications of these variations in methylation on gene expression and health is recommended. ..
  35. ncbi Glucocorticoid receptor variant and risk of dementia and white matter lesions
    Elisabeth F C van Rossum
    Department of Internal Medicine, Erasmus Medical Center, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Neurobiol Aging 29:716-23. 2008
    ..A glucocorticoid receptor gene variant (ER22/23EK) is related to relative glucocorticoid resistance. We investigated whether the ER22/23EK allele is associated with dementia and structural brain abnormalities...
  36. pmc GnRH and LHR gene variants predict adverse outcome in premenopausal breast cancer patients
    Djura Piersma
    Department of Internal Medicine, Erasmus MC, 3000 CA Rotterdam, The Netherlands
    Breast Cancer Res 9:R51. 2007
    ..Breast cancer development and progression are dependent on estrogen activity. In premenopausal women, estrogen production is mainly regulated through the hypothalamic-pituitary-gonadal (HPG) axis...
  37. ncbi C-reactive protein gene haplotypes and risk of coronary heart disease: the Rotterdam Study
    Isabella Kardys
    Department of Epidemiology and Biostatistics, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Eur Heart J 27:1331-7. 2006
    ..We investigated the relation between C-reactive protein haplotypes, representing the comprehensive variation of the C-reactive protein gene, and coronary heart disease...
  38. doi CYP2C9 Genotypes Modify Benzodiazepine-Related Fall Risk: Original Results From Three Studies With Meta-Analysis
    Annelies C Ham
    Department of Internal Medicine, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands
    J Am Med Dir Assoc . 2016
    ..To investigate whether the CYP2C9*2 and *3 variants modify benzodiazepine-related fall risk...
  39. doi Medication-related fall incidents in an older, ambulant population: the B-PROOF study
    Annelies C Ham
    Section of Geriatrics, Department of Internal Medicine, Erasmus MC, University Medical Centre Rotterdam, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Drugs Aging 31:917-27. 2014
    ..Therefore, we investigated the associations indicated in the literature between medication use and falls, using prospectively recorded falls and medication use determined at the time of the fall...
  40. ncbi Clinical impact of cytokine gene polymorphisms in heart and lung transplantation
    Cecile T J Holweg
    Department of Internal Medicine, Erasmus Medical Center, University Medical Center Rotterdam, The Netherlands
    J Heart Lung Transplant 23:1017-26. 2004
  41. ncbi Interleukin 6 -174 g/c promoter polymorphism and risk of coronary heart disease: results from the rotterdam study and a meta-analysis
    Mark P S Sie
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 26:212-7. 2006
    ..We investigated this polymorphism in relation to risk of coronary heart disease (CHD) in a population-based study and meta-analysis...
  42. pmc Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis
    Joyce B J van Meurs
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    JAMA 299:1277-90. 2008
    ..Mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) gene cause rare syndromes characterized by altered bone mineral density (BMD). More common LRP5 variants may affect osteoporosis risk in the general population...
  43. doi Low prevalence of NOD2 SNPs in Behçet's disease suggests protective association in Caucasians
    Jasper H Kappen
    Department of Internal Medicine, Section of Clinical Immunology, Erasmus University Hospital, Rotterdam, The Netherlands
    Rheumatology (Oxford) 48:1375-7. 2009
    ..We studied the frequency of these variants in BD patients...
  44. ncbi Effect of dietary B vitamins on BMD and risk of fracture in elderly men and women: the Rotterdam study
    Nahid Yazdanpanah
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Bone 41:987-94. 2007
    ..These findings highlight the importance of considering nutritional factors in epidemiological studies of osteoporosis and fractures...
  45. ncbi A new polymorphism in the type II deiodinase gene is associated with circulating thyroid hormone parameters
    Robin P Peeters
    Department of Internal Medicine, Rm Ee 502, Erasmus University Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Am J Physiol Endocrinol Metab 289:E75-81. 2005
    ..We hypothesize that this might be explained by the decline in skeletal muscle size during aging, resulting in a relative decrease in the contribution of D2 to serum T(3) production...
  46. ncbi Genetics and biology of vitamin D receptor polymorphisms
    Andre G Uitterlinden
    Genetic Laboratory, Room Ee575, Department of Internal Medicine, Erasmus MC, Dr Molewaterplein 50, PO Box 1738, NL 3000 DR Rotterdam, The Netherlands
    Gene 338:143-56. 2004
    ..Substantial progress has been made that will deepen our understanding of variability in the vitamin D endocrine system and might find applications in risk assessment of disease and in predicting response-to-treatment...
  47. ncbi Femoral neck BMD is a strong predictor of hip fracture susceptibility in elderly men and women because it detects cortical bone instability: the Rotterdam Study
    Fernando Rivadeneira
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Bone Miner Res 22:1781-90. 2007
    ..Cortical instability (propensity of thinner cortices in wide diameters to buckle) explains why hip fracture risk at different BMD levels is the same across sexes...
  48. pmc Effect of Vitamin B12 and Folic Acid Supplementation on Bone Mineral Density and Quantitative Ultrasound Parameters in Older People with an Elevated Plasma Homocysteine Level: B-PROOF, a Randomized Controlled Trial
    Anke W Enneman
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Calcif Tissue Int 96:401-9. 2015
    ....
  49. ncbi Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance
    Roel G W Verhaak
    Department of Hematology, Erasmus University Medical Center Rotterdam, Ee1391a, Dr Molewaterplein 50, 3015 GE Rotterdam Z H, The Netherlands
    Blood 106:3747-54. 2005
    ..Finally, in multivariable analysis NPM1 mutations express independent favorable prognostic value with regard to OS, EFS, and disease-free survival (DFS)...
  50. doi Correlation of breast cancer susceptibility loci with patient characteristics, metastasis-free survival, and mRNA expression of the nearest genes
    Muhammad Riaz
    Department of Medical Oncology, Josephine Nefkens Institute and Daniel den Hoed Cancer Center, Erasmus MC, Building Be, Room 400, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Breast Cancer Res Treat 133:843-51. 2012
    ..Also the prognosis of patients is largely not affected by low-risk breast cancer loci except for the SNP near H19. How, this SNP affects prognosis warrants further study as it does not operate through altering H19 mRNA expression...
  51. pmc Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus
    Carolina Medina-Gómez
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    PLoS Genet 8:e1002718. 2012
    ..Our life-course approach postulates that these genetic effects influencing peak bone mass accrual may impact the risk of osteoporosis later in life...
  52. doi The effect of genetic variation in the type 1 deiodinase gene on the interindividual variation in serum thyroid hormone levels: an investigation in healthy Danish twins
    Wendy M van der Deure
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    Clin Endocrinol (Oxf) 70:954-60. 2009
    ..Genetic factors have a considerable influence on serum thyroid hormone levels. The C785T and A1814G polymorphisms, located in the 3' untranslated region of the type 1 deiodinase (D1) gene have been associated with serum FT4 and rT3 levels...
  53. pmc Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study
    Mandy van Hoek
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    Diabetes 57:3122-8. 2008
    ..Genome-wide association (GWA) studies identified multiple new genetic variants that associate with type 2 diabetes. The predictive value of genetic testing for prediction of type 2 diabetes in the general population is unclear...
  54. pmc Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies
    Fernando Rivadeneira
    Department of Internal Medicine, Rotterdam, The Netherlands
    Nat Genet 41:1199-206. 2009
    ..The many SNPs associated with BMD map to genes in signaling pathways with relevance to bone metabolism and highlight the complex genetic architecture that underlies osteoporosis and variation in BMD...
  55. ncbi Staphylococcus aureus nasal carriage is associated with glucocorticoid receptor gene polymorphisms
    Erica L T Van Den Akker
    Department of Internal Medicine, Erasmus Medical Center, University Medical Center, Rotterdam, The Netherlands
    J Infect Dis 194:814-8. 2006
    ..Thus, genotype-dependent variation in the sensitivity to glucocorticoids is associated with tolerance toward staphylococcal nasal colonization...
  56. doi Effect of vitamin B12 and folic acid supplementation on biomarkers of endothelial function and inflammation among elderly individuals with hyperhomocysteinemia
    Suzanne C van Dijk
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    Vasc Med 21:91-8. 2016
    ..In conclusion, in elderly patients with hyperhomocysteinemia, vitamin B12 and folic acid are unlikely to influence either endothelial function or low-grade systemic inflammation. ClinicalTrials.gov Identifier: NCT00696514...
  57. doi Mild hyponatremia as a risk factor for fractures: the Rotterdam Study
    Ewout J Hoorn
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Bone Miner Res 26:1822-8. 2011
    ..Increased fracture risk in hyponatremia also was independent of recent falls, pointing toward a possible effect on bone quality...
  58. ncbi Cdx-2 polymorphism in the promoter region of the human vitamin D receptor gene determines susceptibility to fracture in the elderly
    Yue Fang
    Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands
    J Bone Miner Res 18:1632-41. 2003
    ..Our findings expand previous similar findings in a Japanese study to whites and show a relationship with fracture risk of this functional polymorphism...
  59. ncbi The increase in cholesterol with menopause is associated with the apolipoprotein E genotype. A population-based longitudinal study
    A Elisabeth Hak
    Department of Internal Medicine, Room D429, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Atherosclerosis 175:169-76. 2004
    ....
  60. ncbi Vitamin D receptor gene polymorphisms in relation to Vitamin D related disease states
    Andre G Uitterlinden
    Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, P O Box 1738, Genetic Laboratory, Room Ee575, NL 3000 DR Rotterdam, The Netherlands
    J Steroid Biochem Mol Biol 89:187-93. 2004
    ..Eventually, results of this research will deepen our understanding of variability in the Vitamin D endocrine system and might find applications in risk-assessment of disease and in predicting response-to-treatment...
  61. ncbi Anti-Müllerian hormone and anti-Müllerian hormone type II receptor polymorphisms are associated with follicular phase estradiol levels in normo-ovulatory women
    Marlies E Kevenaar
    Department of Internal Medicine, Erasmus MC, 3000 CA Rotterdam, The Netherlands
    Hum Reprod 22:1547-54. 2007
    ..Little is known about the role of AMH in human ovarian physiology. We hypothesize that in women AMH has a similar role in ovarian function as in mice and investigated this using a genetic approach...
  62. doi Effects of 2-year vitamin B12 and folic acid supplementation in hyperhomocysteinemic elderly on arterial stiffness and cardiovascular outcomes within the B-PROOF trial
    Suzanne C van Dijk
    aErasmus MC, Department of Internal Medicine, Rotterdam bVU University Medical Center, EMGO Institute for Health and Care Research, Department of Epidemiology and Biostatistics, Amsterdam cWageningen University, Division of Human Nutrition, Wageningen dVU University Medical Center, Department of Clinical Chemistry eVU University Medical Center, Department of Internal Medicine, Amsterdam fNetherlands Consortium for Healthy Ageing, Rotterdam, Leiden gVU University Medical Center, Institute for Cardiovascular Research ICaR VU hAcademic Medical Center, Department of Internal Medicine, Section of Geriatrics, Amsterdam, The Netherlands
    J Hypertens 33:1897-906; discussion 1906. 2015
    ....
  63. pmc Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease
    Joyce B J van Meurs
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    Am J Clin Nutr 98:668-76. 2013
    ....
  64. doi Review of radiological scoring methods of osteoporotic vertebral fractures for clinical and research settings
    Ling Oei
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur Radiol 23:476-86. 2013
    ..Osteoporosis is the most common metabolic bone disease; vertebral fractures are the most common osteoporotic fractures...
  65. pmc Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways
    Lisette Stolk
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    Nat Genet 44:260-8. 2012
    ..Gene-set enrichment pathway analyses using the full GWAS data set identified exoDNase, NF-κB signaling and mitochondrial dysfunction as biological processes related to timing of menopause...
  66. doi Associations between medication use and homocysteine levels in an older population, and potential mediation by vitamin B12 and folate: data from the B-PROOF Study
    Annelies C Ham
    Department of Internal Medicine, Erasmus MC, Geriatric Section, University Medical Centre Rotterdam, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Drugs Aging 31:611-21. 2014
    ..Our objective was to study the associations established previously in more detail by sub-classifying medication groups, and investigate the potential mediating role of vitamin B12 and folate status...
  67. doi Homocysteine level is associated with aortic stiffness in elderly: cross-sectional results from the B-PROOF study
    Suzanne C van Dijk
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Hypertens 31:952-9. 2013
    ..We expect this underlying pathophysiology to be a possible explanation for the association between homocysteine and cardiovascular risk, particularly in older populations...
  68. doi Bone parameters across different types of hip osteoarthritis and their relationship to osteoporotic fracture risk
    Martha C Castano-Betancourt
    Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands
    Arthritis Rheum 65:693-700. 2013
    ....
  69. ncbi Homocysteine levels and the risk of osteoporotic fracture
    Joyce B J van Meurs
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    N Engl J Med 350:2033-41. 2004
    ..We therefore hypothesized that mildly elevated homocysteine levels might be related to age-related osteoporotic fractures...
  70. doi A large-scale association analysis of 68 thyroid hormone pathway genes with serum TSH and FT4 levels
    Marco Medici
    Department of Internal Medicine, Erasmus University Medical Center, 3015 GE Rotterdam, The Netherlands
    Eur J Endocrinol 164:781-8. 2011
    ..We therefore studied the effects of genetic variation in 68 TH pathway genes on serum TSH and free thyroxine (FT(4)) levels...
  71. pmc Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: results of a meta-analysis
    Hanneke J M Kerkhof
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    BMC Med Genet 11:164. 2010
    ..The objective of this study was to examine the relationship between common genetic variation of the ESR2 gene and osteoarthritis...
  72. pmc The epithelial Ca2+ channel TRPV5 is essential for proper osteoclastic bone resorption
    Bram C J van der Eerden
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Proc Natl Acad Sci U S A 102:17507-12. 2005
    ..This report identifies TRPV5 as an epithelial Ca(2+) channel that is essential for osteoclastic bone resorption and demonstrates the significance of transcellular Ca(2+) transport in osteoclastic function...
  73. pmc A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation
    Karol Estrada
    Department of Internal Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    Hum Mol Genet 18:3516-24. 2009
    ..1 x 10(-7)). Taken together, these results suggest that variation in the C-type natriuretic peptide signaling pathway, involving the NPPC and NPR3 genes, plays an important role in determining human body height...
  74. ncbi A polymorphism in type I deiodinase is associated with circulating free insulin-like growth factor I levels and body composition in humans
    Robin P Peeters
    Department of Internal Medicine, Room Ee 502, Erasmus University Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    J Clin Endocrinol Metab 90:256-63. 2005
    ..The association of D1 haplotype allele 2 with serum T(3) levels in the elderly population suggests a relative increase in its contribution to circulating T(3) in old age...
  75. ncbi A common polymorphism renders the luteinizing hormone receptor protein more active by improving signal peptide function and predicts adverse outcome in breast cancer patients
    Djura Piersma
    Department of Internal Medicine, Erasmus MC, Room Ee532, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    J Clin Endocrinol Metab 91:1470-6. 2006
    ..The pituitary gonadotropin LH is an important regulator of estrogen production in premenopausal women, whereas even in women after menopause, 10-25% of ovarian steroid hormone production is LH dependent...
  76. ncbi Association of the ER22/23EK polymorphism in the glucocorticoid receptor gene with survival and C-reactive protein levels in elderly men
    Elisabeth F C van Rossum
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Med 117:158-62. 2004
    ..In the present study, we investigated whether the ER22/23EK polymorphism is associated with survival, cholesterol levels, and two predictors of mortality: serum C-reactive protein and interleukin 6 levels...
  77. pmc GRIMP: a web- and grid-based tool for high-speed analysis of large-scale genome-wide association using imputed data
    Karol Estrada
    Department of Internal Medicine, Erasmus MC, Dr Molewaterplein 50, 3015GE Rotterdam, The Netherlands
    Bioinformatics 25:2750-2. 2009
    ..This is of major importance for the enlargement of GWAS with the availability of whole-genome sequence data from the 1000 Genomes Project and for future whole-population efforts...
  78. ncbi Association of 5' estrogen receptor alpha gene polymorphisms with bone mineral density, vertebral bone area and fracture risk
    Joyce B J van Meurs
    Department of Internal Medicine, Erasmus Medical Centre, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Hum Mol Genet 12:1745-54. 2003
    ..The molecular mechanism underlying this association needs further study...
  79. doi Genetic testing in clinical practice
    Steven W J Lamberts
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Annu Rev Med 60:431-42. 2009
    ..Genomic profiles play a rapidly growing role in the field of pharmacogenomics. A number of recently identified pharmacogenomic biomarkers are helpful to predict drug-related toxic effects...
  80. ncbi Functional heme oxygenase-1 promoter polymorphism in relation to heart failure and cardiac transplantation
    Cecile T J Holweg
    Department of Internal Medicine, University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Heart Lung Transplant 24:493-7. 2005
    ..No influence of the polymorphism on the development of heart failure, graft survival, acute rejection, or transplant atherosclerosis was found...