Fernando Rivadeneira

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. ncbi request reprint Association between an insulin-like growth factor I gene promoter polymorphism and bone mineral density in the elderly: the Rotterdam Study
    Fernando Rivadeneira
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands
    J Clin Endocrinol Metab 88:3878-84. 2003
  2. ncbi request reprint Femoral neck BMD is a strong predictor of hip fracture susceptibility in elderly men and women because it detects cortical bone instability: the Rotterdam Study
    Fernando Rivadeneira
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Bone Miner Res 22:1781-90. 2007
  3. ncbi request reprint Effect of dietary B vitamins on BMD and risk of fracture in elderly men and women: the Rotterdam study
    Nahid Yazdanpanah
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Bone 41:987-94. 2007
  4. doi request reprint Large-scale analysis of association between polymorphisms in the transforming growth factor beta 1 gene (TGFB1) and osteoporosis: the GENOMOS study
    Bente L Langdahl
    Department of Endocrinology, Aarhus University Hospital, Aarhus, Denmark
    Bone 42:969-81. 2008
  5. doi request reprint Identification of a common variant at the NOS1AP locus strongly associated to QT-interval duration
    Mark Eijgelsheim
    Department of Epidemiology, Erasmus Medical Center 3000, CA, Rotterdam, The Netherlands
    Hum Mol Genet 18:347-57. 2009
  6. doi request reprint Osteoporosis and Bone Mass Disorders: From Gene Pathways to Treatments
    Fernando Rivadeneira
    Musculoskeletal Genomics, Health and Metabolism, Departments of Internal Medicine and Epidemiology, Erasmus University Medical Center, 3000CA Rotterdam, The Netherlands Electronic address
    Trends Endocrinol Metab 27:262-81. 2016
  7. pmc Reproductive aging-associated common genetic variants and the risk of breast cancer
    Chunyan He
    Department of Public Health, Indiana University School of Medicine, 980 West Walnut Street, R3 C241, Indianapolis, IN 46202, USA
    Breast Cancer Res 14:R54. 2012
  8. pmc Association between bone mineral density and type 2 diabetes mellitus: a meta-analysis of observational studies
    Lili Ma
    Department of Rheumatology, Fudan University, Shanghai, China
    Eur J Epidemiol 27:319-32. 2012
  9. ncbi request reprint Estrogen receptor beta (ESR2) polymorphisms in interaction with estrogen receptor alpha (ESR1) and insulin-like growth factor I (IGF1) variants influence the risk of fracture in postmenopausal women
    Fernando Rivadeneira
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Bone Miner Res 21:1443-56. 2006
  10. pmc SIRT1 genetic variation is related to BMI and risk of obesity
    M Carola Zillikens
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Diabetes 58:2828-34. 2009

Detail Information

Publications95

  1. ncbi request reprint Association between an insulin-like growth factor I gene promoter polymorphism and bone mineral density in the elderly: the Rotterdam Study
    Fernando Rivadeneira
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands
    J Clin Endocrinol Metab 88:3878-84. 2003
    ..Our findings suggest that this promoter polymorphism or another functional polymorphism in linkage disequilibrium may be a genetic determinant of BMD levels and rate of bone loss in postmenopausal women...
  2. ncbi request reprint Femoral neck BMD is a strong predictor of hip fracture susceptibility in elderly men and women because it detects cortical bone instability: the Rotterdam Study
    Fernando Rivadeneira
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Bone Miner Res 22:1781-90. 2007
    ..Cortical instability (propensity of thinner cortices in wide diameters to buckle) explains why hip fracture risk at different BMD levels is the same across sexes...
  3. ncbi request reprint Effect of dietary B vitamins on BMD and risk of fracture in elderly men and women: the Rotterdam study
    Nahid Yazdanpanah
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Bone 41:987-94. 2007
    ..These findings highlight the importance of considering nutritional factors in epidemiological studies of osteoporosis and fractures...
  4. doi request reprint Large-scale analysis of association between polymorphisms in the transforming growth factor beta 1 gene (TGFB1) and osteoporosis: the GENOMOS study
    Bente L Langdahl
    Department of Endocrinology, Aarhus University Hospital, Aarhus, Denmark
    Bone 42:969-81. 2008
    ....
  5. doi request reprint Identification of a common variant at the NOS1AP locus strongly associated to QT-interval duration
    Mark Eijgelsheim
    Department of Epidemiology, Erasmus Medical Center 3000, CA, Rotterdam, The Netherlands
    Hum Mol Genet 18:347-57. 2009
    ..In conclusion, we found rs12143842 6 kb upstream distance of NOS1AP to be more strongly associated to QT-interval duration than rs10494366T > G. Functional analysis of this marker is warranted...
  6. doi request reprint Osteoporosis and Bone Mass Disorders: From Gene Pathways to Treatments
    Fernando Rivadeneira
    Musculoskeletal Genomics, Health and Metabolism, Departments of Internal Medicine and Epidemiology, Erasmus University Medical Center, 3000CA Rotterdam, The Netherlands Electronic address
    Trends Endocrinol Metab 27:262-81. 2016
    ..The insight provided by genetic studies is serving the identification of biomarkers predictive of disease, redefining disease, response to treatment, and discovery of novel drug targets for skeletal disorders. ..
  7. pmc Reproductive aging-associated common genetic variants and the risk of breast cancer
    Chunyan He
    Department of Public Health, Indiana University School of Medicine, 980 West Walnut Street, R3 C241, Indianapolis, IN 46202, USA
    Breast Cancer Res 14:R54. 2012
    ..Recent genome-wide association studies have identified several novel genetic loci associated with these two traits. However, the association between these loci and breast cancer risk is unknown...
  8. pmc Association between bone mineral density and type 2 diabetes mellitus: a meta-analysis of observational studies
    Lili Ma
    Department of Rheumatology, Fudan University, Shanghai, China
    Eur J Epidemiol 27:319-32. 2012
    ..We conclude that individuals with T2DM from both genders have higher BMD levels, but that multiple factors influence BMD in individuals with T2DM...
  9. ncbi request reprint Estrogen receptor beta (ESR2) polymorphisms in interaction with estrogen receptor alpha (ESR1) and insulin-like growth factor I (IGF1) variants influence the risk of fracture in postmenopausal women
    Fernando Rivadeneira
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Bone Miner Res 21:1443-56. 2006
    ..Interaction of ESR2 with ESR1 and IGF1 was determined and revealed a deleterious genetic combination that enhances the risk of osteoporotic fracture...
  10. pmc SIRT1 genetic variation is related to BMI and risk of obesity
    M Carola Zillikens
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Diabetes 58:2828-34. 2009
    ..SIRT1 has pleiotropic metabolic functions. We investigated whether SIRT1 genetic variation is associated with obesity...
  11. ncbi request reprint The influence of an insulin-like growth factor I gene promoter polymorphism on hip bone geometry and the risk of nonvertebral fracture in the elderly: the Rotterdam Study
    Fernando Rivadeneira
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    J Bone Miner Res 19:1280-90. 2004
    ..5; 95% CI, 1.1-2.0) of fragility fracture in women (n = 4212) but not in men (n = 2799). An approximation of hip bone geometry (from DXA) suggested the polymorphism is associated with bone strength and stability in gender-specific ways...
  12. doi request reprint Clinical implications of old and new genes for open-angle glaucoma
    Wishal D Ramdas
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Ophthalmology 118:2389-97. 2011
    ..This study was performed to determine to what extent variants within established genes (MYOC, OPTN, and WDR36) and newly identified common genetic variants (ATOH7, CDKN2B, and SIX1) contribute to the risk of OAG...
  13. pmc Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture
    Karol Estrada
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Nat Genet 44:491-501. 2012
    ..3 (SLC25A13), 11q13.2 (LRP5), 4q22.1 (MEPE), 2p16.2 (SPTBN1) and 10q21.1 (DKK1). These findings shed light on the genetic architecture and pathophysiological mechanisms underlying BMD variation and fracture susceptibility...
  14. ncbi request reprint BMP-2 gene polymorphisms and osteoporosis: the Rotterdam Study
    Marco Medici
    Department of Internal Medicine Erasmus Medical Center, Rotterdam, The Netherlands
    J Bone Miner Res 21:845-54. 2006
    ..We did not observe an association of these variants with BMD, bone loss, hip structural analysis parameters, and fracture risk...
  15. pmc The -1997 G/T and Sp1 polymorphisms in the collagen type I alpha1 (COLIA1) gene in relation to changes in femoral neck bone mineral density and the risk of fracture in the elderly: the Rotterdam study
    Nahid Yazdanpanah
    Netherlands Institute for Health Science, Rotterdam, The Netherlands
    Calcif Tissue Int 81:18-25. 2007
    ..7, P = 0.001). We confirm that the COLIA1 Sp1 polymorphism influences BMD and the risk of fracture in postmenopausal Caucasian women. In contrast, we found no independent effect of the -1997 G/T promoter polymorphism on BMD or fracture...
  16. doi request reprint SIRT1 genetic variation and mortality in type 2 diabetes: interaction with smoking and dietary niacin
    M Carola Zillikens
    Department of Internal Medicine, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    Free Radic Biol Med 46:836-41. 2009
    ..Correction of niacin deficiency and SIRT1 modulators may prolong the life span of patients with diabetes...
  17. pmc Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process
    Henriët Springelkamp
    1 Department of Ophthalmology, Erasmus Medical Center, Rotterdam 3000 CA, The Netherlands 2 Department of Epidemiology, Erasmus Medical Center, Rotterdam 3000 CA, The Netherlands
    Nat Commun 5:4883. 2014
    ..This study has more than doubled the known loci associated with optic disc cupping and will allow greater understanding of mechanisms involved in this common blinding condition. ..
  18. doi request reprint Serum C reactive protein levels and genetic variation in the CRP gene are not associated with the prevalence, incidence or progression of osteoarthritis independent of body mass index
    Hanneke J M Kerkhof
    Department of Internal Medicine, Erasmus Medical Center Rotterdam, The Netherlands
    Ann Rheum Dis 69:1976-82. 2010
    ..A systematic review of studies assessing the relationship between osteoarthritis (OA) and CRP levels was also performed...
  19. pmc The role of body mass index, insulin, and adiponectin in the relation between fat distribution and bone mineral density
    M Carola Zillikens
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Calcif Tissue Int 86:116-25. 2010
    ..Inverse associations after adjustment for BMI suggest that android fat deposition as measured by the WHR, WTR, and DXA-based android-to-gynoid fat ratio is not beneficial and possibly even deleterious for bone...
  20. ncbi request reprint Low dietary riboflavin but not folate predicts increased fracture risk in postmenopausal women homozygous for the MTHFR 677 T allele
    Nahid Yazdanpanah
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Bone Miner Res 23:86-94. 2008
    ..We found that the MTHFR C677T variant interacts with dietary riboflavin intake to influence fracture risk in women...
  21. doi request reprint Interactions between dietary vitamin E intake and SIRT1 genetic variation influence body mass index
    M Carola Zillikens
    Department of Internal Medicine, Room D428, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Am J Clin Nutr 91:1387-93. 2010
    ..Genetic variation in SIRT1 has been associated with body mass index (BMI) and risk of obesity. SIRT1 may be influenced by diet...
  22. ncbi request reprint Common genetic variation of the low-density lipoprotein receptor-related protein 5 and 6 genes determines fracture risk in elderly white men
    Joyce B J van Meurs
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Bone Miner Res 21:141-50. 2006
    ..LRP5 variation was associated to both BMD and frame size, whereas both LRP5 and 6 variations were associated with an increased fracture risk in males...
  23. ncbi request reprint Vitamin D receptor gene haplotype is associated with body height and bone size
    Yue Fang
    Genetic Laboratory, Room Ee575, Department of Internal Medicine, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    J Clin Endocrinol Metab 92:1491-501. 2007
    ..We recently identified promoter and 3'-untranslated region (UTR) haplotype alleles that influence vitamin D receptor (VDR) mRNA expression...
  24. pmc Polymorphisms in the sclerosteosis/van Buchem disease gene (SOST) region are associated with bone-mineral density in elderly whites
    Andre G Uitterlinden
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Hum Genet 75:1032-45. 2004
    ..02). The molecular mechanism whereby these moderate SOST genotype effects are mediated remains to be elucidated, but it is likely to involve differences in regulation of SOST gene expression...
  25. pmc Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis
    Joyce B J van Meurs
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    JAMA 299:1277-90. 2008
    ..Mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) gene cause rare syndromes characterized by altered bone mineral density (BMD). More common LRP5 variants may affect osteoporosis risk in the general population...
  26. pmc Education influences the role of genetics in myopia
    Virginie J M Verhoeven
    Department of Ophthalmology, Erasmus Medical Center, Room Na 2808, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Epidemiol 28:973-80. 2013
    ..2, 95 % CI 1.9-9.5). This epidemiological study provides evidence of a gene-environment interaction in which an individual's genetic risk of myopia is significantly affected by his or her educational level...
  27. doi request reprint A genetic epidemiologic study of candidate genes involved in the optic nerve head morphology
    Andrea C Gasten
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Invest Ophthalmol Vis Sci 53:1485-91. 2012
    ..The purpose of the present study was to investigate whether genes encoding protein known to interact with protein encoded by SALL1 and SIX1 are also associated with either DA or VCDR...
  28. doi request reprint The T-13910C polymorphism in the lactase phlorizin hydrolase gene is associated with differences in serum calcium levels and calcium intake
    W Nadia H Koek
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    J Bone Miner Res 25:1980-7. 2010
    ....
  29. doi request reprint Common genetic variants associated with open-angle glaucoma
    Wishal D Ramdas
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Hum Mol Genet 20:2464-71. 2011
    ..These findings may shed new light on the pathophysiological protein pathways leading to glaucoma, and point to pathways involved in the growth and development of the optic nerve...
  30. pmc Loci at chromosomes 13, 19 and 20 influence age at natural menopause
    Lisette Stolk
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    Nat Genet 41:645-7. 2009
    ..5 year per A allele (12%); P = 2.5 × 10(-8)). These common genetic variants regulate timing of ovarian aging, an important risk factor for breast cancer, osteoporosis and cardiovascular disease...
  31. pmc High bone mineral density and fracture risk in type 2 diabetes as skeletal complications of inadequate glucose control: the Rotterdam Study
    Ling Oei
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Diabetes Care 36:1619-28. 2013
    ..Individuals with type 2 diabetes have increased fracture risk despite higher bone mineral density (BMD). Our aim was to examine the influence of glucose control on skeletal complications...
  32. doi request reprint Bone parameters across different types of hip osteoarthritis and their relationship to osteoporotic fracture risk
    Martha C Castano-Betancourt
    Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands
    Arthritis Rheum 65:693-700. 2013
    ....
  33. pmc Promoter and 3'-untranslated-region haplotypes in the vitamin d receptor gene predispose to osteoporotic fracture: the rotterdam study
    Yue Fang
    Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands
    Am J Hum Genet 77:807-23. 2005
    ..This could impact the vitamin D signaling efficiency and might contribute to the increased fracture risk we observed for these risk haplotype alleles...
  34. doi request reprint Genetic architecture of open angle glaucoma and related determinants
    Wishal D Ramdas
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Med Genet 48:190-6. 2011
    ..We evaluated whether the same genes that determine VCDR and IOP also predict OAG...
  35. doi request reprint Maternal first-trimester diet and childhood bone mass: the Generation R Study
    Denise H M Heppe
    Generation R Study Group and the Department of Paediatrics, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Clin Nutr 98:224-32. 2013
    ..Maternal diet during pregnancy has been suggested to influence bone health in later life...
  36. pmc Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia
    Virginie J M Verhoeven
    Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands
    Nat Genet 45:314-8. 2013
    ..Our results, based on a large meta-analysis across independent multiancestry studies, considerably advance understanding of the mechanisms involved in refractive error and myopia...
  37. pmc Common genetic determinants of intraocular pressure and primary open-angle glaucoma
    Leonieke M E van Koolwijk
    Glaucoma Service, The Rotterdam Eye Hospital, Rotterdam, The Netherlands
    PLoS Genet 8:e1002611. 2012
    ..Both genes functionally interact with known glaucoma disease genes. These data suggest that we have identified two clinically relevant genes involved in IOP regulation...
  38. ncbi request reprint Vitamin D receptor gene BsmI and TaqI polymorphisms and fracture risk: a meta-analysis
    Yue Fang
    Department of Internal Medicine, Erasmus MC, 3015 GD Rotterdam, The Netherlands
    Bone 39:938-45. 2006
    ..The vitamin D receptor (VDR) gene is thought to be a candidate gene for osteoporosis. Many genetic studies have suggested an association of VDR polymorphisms and osteoporosis, but evidence remains conflicting...
  39. doi request reprint Low prevalence of NOD2 SNPs in Behçet's disease suggests protective association in Caucasians
    Jasper H Kappen
    Department of Internal Medicine, Section of Clinical Immunology, Erasmus University Hospital, Rotterdam, The Netherlands
    Rheumatology (Oxford) 48:1375-7. 2009
    ..We studied the frequency of these variants in BD patients...
  40. pmc Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies
    Fernando Rivadeneira
    Department of Internal Medicine, Rotterdam, The Netherlands
    Nat Genet 41:1199-206. 2009
    ..The many SNPs associated with BMD map to genes in signaling pathways with relevance to bone metabolism and highlight the complex genetic architecture that underlies osteoporosis and variation in BMD...
  41. doi request reprint The Influence of Serum Uric Acid on Bone Mineral Density, Hip Geometry, and Fracture Risk: The Rotterdam Study
    Taulant Muka
    Departments of Epidemiology T M, E A L d J, J C K d J, A G U, A H, A D, O H F, F R and Internal Medicine E A L d J, A G U, M C Z, F R, Erasmus Medical Center, Rotterdam CA 3000, The Netherlands Netherlands Consortium for Healthy Ageing A G U, A H, A D, M C Z, O H F, F R, Netherlands Genomics Initiative, The Hague 2593 CE, The Netherlands and Leiden University College J C K d J, The Hague 3595 DG, The Netherlands
    J Clin Endocrinol Metab 101:1113-22. 2016
    ..The role of uric acid (UA) in skeletal metabolism remains to be unraveled...
  42. pmc A genome-wide association study identifies five loci influencing facial morphology in Europeans
    Fan Liu
    Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    PLoS Genet 8:e1002932. 2012
    ....
  43. pmc The Generation R Study: design and cohort update 2017
    Marjolein N Kooijman
    The Generation R Study Group NA 2915, Erasmus Medical Center, University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Epidemiol . 2017
    ..Genome and epigenome wide association screens are available. Eventually, results from the Generation R Study contribute to the development of strategies for optimizing health and healthcare for pregnant women and children...
  44. pmc Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus
    Carolina Medina-Gómez
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    PLoS Genet 8:e1002718. 2012
    ..Our life-course approach postulates that these genetic effects influencing peak bone mass accrual may impact the risk of osteoporosis later in life...
  45. pmc A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22
    Hanneke J M Kerkhof
    Erasmus Medical Centre, Rotterdam, The Netherlands
    Arthritis Rheum 62:499-510. 2010
    ..To identify novel genes involved in osteoarthritis (OA), by means of a genome-wide association study...
  46. ncbi request reprint The association between common vitamin D receptor gene variations and osteoporosis: a participant-level meta-analysis
    Andre G Uitterlinden
    Erasmus MC, Rotterdam, The Netherlands
    Ann Intern Med 145:255-64. 2006
    ..Polymorphisms of the vitamin D receptor (VDR) gene have been implicated in the genetic regulation of bone mineral density (BMD). However, the clinical impact of these variants remains unclear...
  47. pmc Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease
    Marco Medici
    Department of Internal Medicine, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands
    PLoS Genet 10:e1004123. 2014
    ....
  48. pmc A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation
    Karol Estrada
    Department of Internal Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    Hum Mol Genet 18:3516-24. 2009
    ..1 x 10(-7)). Taken together, these results suggest that variation in the C-type natriuretic peptide signaling pathway, involving the NPPC and NPR3 genes, plays an important role in determining human body height...
  49. doi request reprint Bone Mass and Strength in School-Age Children Exhibit Sexual Dimorphism Related to Differences in Lean Mass: The Generation R Study
    Carolina Medina-Gómez
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Bone Miner Res 31:1099-106. 2016
    ..2015 American Society for Bone and Mineral Research. ..
  50. pmc Genome-wide association study in an admixed case series reveals IL12A as a new candidate in Behçet disease
    Jasper H Kappen
    Internal Medicine, Section Immunology, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS ONE 10:e0119085. 2015
    ..However, novel statistical approaches have now enabled GWAS in admixed cohorts...
  51. ncbi request reprint A polymorphism in the AMH type II receptor gene is associated with age at menopause in interaction with parity
    Marlies E Kevenaar
    Department of Internal Medicine, Room Ee532, PO Box 2040, Erasmus MC, 3000 CA Rotterdam, The Netherlands
    Hum Reprod 22:2382-8. 2007
    ..Since age at menopause has a strong genetic component, we investigated the role of AMH signaling using a candidate gene approach...
  52. pmc Genome-wide profiling of blood pressure in adults and children
    Hendrik R Taal
    The Generation R Study Group AE 006, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Hypertension 59:241-7. 2012
    ....
  53. doi request reprint Common DNA variants predict tall stature in Europeans
    Fan Liu
    Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Hum Genet 133:587-97. 2014
    ....
  54. doi request reprint Scheuermann disease: evaluation of radiological criteria and population prevalence
    Ater A Makurthou
    From the Departments of Internal Medicine Radiology, and Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands and Netherlands Genomics Initiative sponsored Netherlands Consortium for Healthy Aging, The Hague, The Netherlands
    Spine (Phila Pa 1976) 38:1690-4. 2013
    ..Observational population-based study...
  55. pmc Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease
    Joyce B J van Meurs
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    Am J Clin Nutr 98:668-76. 2013
    ....
  56. doi request reprint Review of radiological scoring methods of osteoporotic vertebral fractures for clinical and research settings
    Ling Oei
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur Radiol 23:476-86. 2013
    ..Osteoporosis is the most common metabolic bone disease; vertebral fractures are the most common osteoporotic fractures...
  57. pmc Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: results of a meta-analysis
    Hanneke J M Kerkhof
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    BMC Med Genet 11:164. 2010
    ..The objective of this study was to examine the relationship between common genetic variation of the ESR2 gene and osteoarthritis...
  58. pmc Genomewide association studies of stroke
    M Arfan Ikram
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    N Engl J Med 360:1718-28. 2009
    ..The genes underlying the risk of stroke in the general population remain undetermined...
  59. doi request reprint Mild hyponatremia as a risk factor for fractures: the Rotterdam Study
    Ewout J Hoorn
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Bone Miner Res 26:1822-8. 2011
    ..Increased fracture risk in hyponatremia also was independent of recent falls, pointing toward a possible effect on bone quality...
  60. pmc Genome-Wide Association Study for Incident Myocardial Infarction and Coronary Heart Disease in Prospective Cohort Studies: The CHARGE Consortium
    Abbas Dehghan
    Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
    PLoS ONE 11:e0144997. 2016
    ..Data are limited on genome-wide association studies (GWAS) for incident coronary heart disease (CHD). Moreover, it is not known whether genetic variants identified to date also associate with risk of CHD in a prospective setting...
  61. doi request reprint Genome-wide Association Study for Radiographic Vertebral Fractures: A Potential Role for the 16q24 BMD Locus versus Lessons Learned from Challenging Phenotype Definition
    Ling Oei
    Department of Internal Medicine, Erasmus Medical Center Rotterdam, The Netherlands Department of Epidemiology, Erasmus Medical Center Rotterdam, The Netherlands Netherlands Genomics Initiative NGI sponsored Netherlands Consortium for Healthy Aging NCHA, The Netherlands Electronic address
    Bone . 2013
    ..10, more of the type expected in complex traits. Larger effort in studies with standardized phenotype definitions are needed to confirm or reject the involvement of this locus on the risk for vertebral fractures...
  62. ncbi request reprint Dietary patterns in an elderly population and their relation with bone mineral density: the Rotterdam Study
    Ester A L de Jonge
    Department of Epidemiology, Erasmus MC, Dr Molewaterplein 50, PO Box 2040, 3000, Rotterdam, The Netherlands
    Eur J Nutr . 2016
    ..Our aim was to identify dietary patterns that are associated with bone mineral density (BMD) against a background of relatively high dairy intake in elderly Dutch subjects...
  63. pmc The Association between Metabolic Syndrome, Bone Mineral Density, Hip Bone Geometry and Fracture Risk: The Rotterdam Study
    Taulant Muka
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS ONE 10:e0129116. 2015
    ..In conclusion, women with MS had higher FN-BMD independent of BMI. The glucose component of MS was associated with high FN-BMD in both genders, highlighting the need to preserve glycemic control to prevent skeletal complications. ..
  64. doi request reprint The Generation R Study: Biobank update 2015
    Claudia J Kruithof
    The Generation R Study Group NA 2915, Erasmus University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Epidemiol 29:911-27. 2014
    ....
  65. doi request reprint Fast linear mixed model computations for genome-wide association studies with longitudinal data
    Karolina Sikorska
    Department of Biostatistics, Erasmus Medical Center, Rotterdam, Netherlands
    Stat Med 32:165-80. 2013
    ..In a simulation study, we compare several fast methods with respect to their accuracy and speed. The conditional two-step approach is applied to relate SNPs to longitudinal bone mineral density responses collected in the Rotterdam Study...
  66. pmc Large common deletions associate with mortality at old age
    Maris Kuningas
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, CA 3000, The Netherlands
    Hum Mol Genet 20:4290-6. 2011
    ..3 region (combined HR 1.57, 95% CI 1.19-2.07, P = 1.53 × 10(-3)) does not encompass any genes. In conclusion, the burden of large common deletions, as well as common CNVs in 11p15.5 and 14q21.3 region, associate with higher mortality...
  67. pmc Development of a Food Group-Based Diet Score and Its Association with Bone Mineral Density in the Elderly: The Rotterdam Study
    Ester A L de Jonge
    Department of Epidemiology, Erasmus MC, University Medical Centre, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Nutrients 7:6974-90. 2015
    ..The food groups included in our BMD-Diet Score could be considered in the development of future dietary guidelines for healthy ageing. ..
  68. pmc Meta-analysis of Genome-Wide Association Studies Identifies Novel Loci Associated With Optic Disc Morphology
    Henriët Springelkamp
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands
    Genet Epidemiol 39:207-16. 2015
    ..The new genes participate in a number of pathways and future work is likely to identify more functions related to the pathogenesis of glaucoma. ..
  69. pmc Digital quantification of human eye color highlights genetic association of three new loci
    Fan Liu
    Department of Forensic Molecular Biology, Erasmus University Medical Center, Rotterdam, The Netherlands
    PLoS Genet 6:e1000934. 2010
    ..A model for predicting quantitative eye colors explained over 50% of trait variance in the Rotterdam Study. Over all our data exemplify that fine phenotyping is a useful strategy for finding genes involved in human complex traits...
  70. doi request reprint Serum testosterone levels in males are not associated with entrepreneurial behavior in two independent observational studies
    Matthijs J H M van der Loos
    Department of Applied Economics, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, The Netherlands
    Physiol Behav 119:110-4. 2013
    ..To our knowledge, this is the first large-scale study on the relationship between serum T and entrepreneurial behavior. ..
  71. doi request reprint Genome-wide association study of vascular dementia
    Elisabeth M C Schrijvers
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Stroke 43:315-9. 2012
    ..Most studies investigating the genetics of dementia have focused on Alzheimer disease, but little is known about the genetics of vascular dementia. The aim of our study was to identify new loci associated with vascular dementia...
  72. pmc Large scale international replication and meta-analysis study confirms association of the 15q14 locus with myopia. The CREAM consortium
    Virginie J M Verhoeven
    Department of Ophthalmology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    Hum Genet 131:1467-80. 2012
    ..SNPs at locus 15q25 did not replicate significantly (P value 5.81 × 10(-2) for top SNP rs939661). We conclude that common variants at chromosome 15q14 influence susceptibility for myopia in Caucasian and Asian populations world-wide...
  73. pmc Common variants at 6q22 and 17q21 are associated with intracranial volume
    M Arfan Ikram
    Department of Epidemiology, Erasmus Medical Center University Medical Center, Rotterdam, The Netherlands
    Nat Genet 44:539-44. 2012
    ..5 months). Our data identify two loci associated with head size, with the inversion at 17q21 also likely to be involved in attaining maximal brain size...
  74. pmc Common variants at 12q15 and 12q24 are associated with infant head circumference
    H Rob Taal
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Nat Genet 44:532-8. 2012
    ....
  75. pmc Association of HSP70 and its co-chaperones with Alzheimer's disease
    Linda Broer
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Alzheimers Dis 25:93-102. 2011
    ..However, our findings of the single SNP analysis and pathway analysis suggest that multiple genetic variants in prefoldin are associated with AD...
  76. ncbi request reprint Effects of serum TSH and FT4 levels and the TSHR-Asp727Glu polymorphism on bone: the Rotterdam Study
    Wendy M van der Deure
    Department of Internal Medicine, Erasmus University Medical Centre, Rotterdam, The Netherlands
    Clin Endocrinol (Oxf) 68:175-81. 2008
    ..The TSHR-Asp727Glu polymorphism is associated with lower TSH levels. We therefore examined the association of this polymorphism with bone parameters...
  77. doi request reprint A simple risk score for the assessment of absolute fracture risk in general practice based on two longitudinal studies
    Saskia M F Pluijm
    Department of Public Health, Erasmus MC, Rotterdam, The Netherlands
    J Bone Miner Res 24:768-74. 2009
    ..A simple risk score can satisfactorily identify older women at high risk of osteoporotic fractures in general practice. Future studies are needed to validate this score...
  78. pmc Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts
    Abbas Dehghan
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Circ Cardiovasc Genet 2:125-33. 2009
    ..Fibrinogen is both central to blood coagulation and an acute-phase reactant. We aimed to identify common variants influencing circulation fibrinogen levels...
  79. pmc Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations
    Ayse Demirkan
    Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
    PLoS Genet 8:e1002490. 2012
    ..In conclusion, our study identified nine novel phospho- and sphingolipid loci, substantially increasing our knowledge of the genetic basis for these traits...
  80. pmc Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo
    M Kamran Ikram
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS Genet 6:e1001184. 2010
    ..These data provide further insights into the contribution and biological mechanisms of microcirculatory changes that underlie cardiovascular disease...
  81. pmc A genome-wide association study of optic disc parameters
    Wishal D Ramdas
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS Genet 6:e1000978. 2010
    ..Three of the loci were marginally associated with open-angle glaucoma. The protein pathways in which the loci of optic disc area are involved overlap with those identified for VCDR, suggesting a common genetic origin...
  82. pmc A genome-wide association study identifies a susceptibility locus for refractive errors and myopia at 15q14
    Abbas M Solouki
    Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands
    Nat Genet 42:897-901. 2010
    ..Our data suggest that common variants at 15q14 influence susceptibility for refractive errors in the general population...
  83. pmc Three genome-wide association studies and a linkage analysis identify HERC2 as a human iris color gene
    Manfred Kayser
    Department of Forensic Molecular Biology, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands
    Am J Hum Genet 82:411-23. 2008
    ..Testing markers in the HERC2-OCA2 region may be useful in forensic applications to predict eye color phenotypes of unknown persons of European genetic origin...
  84. pmc Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region
    Marjolein J Peters
    Department of Internal Medicine, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands
    Ann Rheum Dis 72:427-36. 2013
    ..In the first large-scale genome-wide association study (GWAS) meta-analysis, we aimed to identify common genetic variants associated with CWP...
  85. doi request reprint The Generation R Study: design and cohort update 2012
    Vincent W V Jaddoe
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Epidemiol 27:739-56. 2012
    ..Eventually, results forthcoming from the Generation R Study contribute to the development of strategies for optimizing health and healthcare for pregnant women and children...
  86. doi request reprint A genome-wide association study of acenocoumarol maintenance dosage
    Martina Teichert
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Hum Mol Genet 18:3758-68. 2009
    ..Besides age, gender, body mass index and target INR, one polymorphism within each of the VKORC1, CYP2C9, CYP4F2 and CYP2C18 genes could explain 48.8% of acenocoumarol dosage variation...
  87. doi request reprint Replication study of chr17q25 with cerebral white matter lesion volume
    Benjamin F J Verhaaren
    Department of Epidemiology, Erasmus MC University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Stroke 42:3297-9. 2011
    ..We report on the first independent replication study of this genetic association...
  88. doi request reprint A child with a deletion in the monocarboxylate transporter 8 gene: 7-year follow-up and effects of thyroid hormone treatment
    Amnon Zung
    Pediatric Endocrinology Unit, Kaplan Medical Center, Affiliated with the Hebrew University of Jerusalem, Rehovot 76100, Israel Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    Eur J Endocrinol 165:823-30. 2011
    ....
  89. pmc GRIMP: a web- and grid-based tool for high-speed analysis of large-scale genome-wide association using imputed data
    Karol Estrada
    Department of Internal Medicine, Erasmus MC, Dr Molewaterplein 50, 3015GE Rotterdam, The Netherlands
    Bioinformatics 25:2750-2. 2009
    ..This is of major importance for the enlargement of GWAS with the availability of whole-genome sequence data from the 1000 Genomes Project and for future whole-population efforts...
  90. pmc Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis
    Martha C Castano Betancourt
    Department of Internal Medicine, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands
    Proc Natl Acad Sci U S A 109:8218-23. 2012
    ..These data are a further step to better understand the role of Wnt-signaling during chondrogenesis and cartilage homeostasis. DOT1L may represent a therapeutic target for OA...
  91. pmc Dual energy x-ray absorptiometry analysis contributes to the prediction of hip osteoarthritis progression
    Martha C Castaño Betancourt
    Orthopaedic Research Laboratory, Erasmus Medical Center, Dr Mollewaterplein 50, 3000 CA, Rotterdam, The Netherlands
    Arthritis Res Ther 11:R162. 2009
    ....
  92. pmc Genome-wide association analysis identifies multiple loci related to resting heart rate
    Mark Eijgelsheim
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Hum Mol Genet 19:3885-94. 2010
    ..6%, suggesting that some loci falling short of genome-wide significance are likely truly associated. Future research is warranted to elucidate underlying mechanisms that may impact clinical care...
  93. pmc Genome-wide association study identifies novel breast cancer susceptibility loci
    Douglas F Easton
    CR UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK
    Nature 447:1087-93. 2007
    ..05 level compared with an estimated 1,343 that would be expected by chance, indicating that many additional common susceptibility alleles may be identifiable by this approach...
  94. doi request reprint Correlation between genetic and geographic structure in Europe
    Oscar Lao
    Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands
    Curr Biol 18:1241-8. 2008
    ..By including the widely used CEPH from Utah (CEU) samples into our analysis, we could show that these individuals represent northern and western Europeans reasonably well, thereby confirming their assumed regional ancestry...
  95. pmc Large-scale evidence for the effect of the COLIA1 Sp1 polymorphism on osteoporosis outcomes: the GENOMOS study
    Stuart H Ralston
    Rheumatic Diseases Unit, University of Edinburgh, Western General Hospital Edinburgh, Edinburgh, United Kingdom
    PLoS Med 3:e90. 2006
    ....