R Pieters

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. doi request reprint Pregnancy outcome of non-anonymous oocyte donation: a case-control study
    Wendy van Dorp
    Department of Gynaecology and Obstetrics, Division Reproductive Medicine, Erasmus MC University Medical Centre Rotterdam, s Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands Department of Paediatric Oncology Haematology, Erasmus MC Sophia Children s Hospital, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands Electronic address
    Eur J Obstet Gynecol Reprod Biol 182:107-12. 2014
  2. doi request reprint Decreased ovarian function is associated with obesity in very long-term female survivors of childhood cancer
    W van Dorp
    Department of Paediatric Oncology Haematology, Erasmus MC Sophia Children s Hospital, Dr Molewaterplein 60, 3015 GJ, Rotterdam, The Netherlands
    Eur J Endocrinol 168:905-12. 2013
  3. doi request reprint Genetic variation may modify ovarian reserve in female childhood cancer survivors
    W van Dorp
    Department of Paediatric Oncology Haematology, ErasmusMC University Medical Centre Sophia s Children s Hospital Rotterdam, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands
    Hum Reprod 28:1069-76. 2013
  4. doi request reprint Gonadal function recovery in very long-term male survivors of childhood cancer
    Wendy van Dorp
    Department of Paediatric Oncology Haematology, Erasmus MC Sophia Children s Hospital, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands
    Eur J Cancer 49:1280-6. 2013
  5. doi request reprint Long-term endocrine side effects of childhood Hodgkin's lymphoma treatment: a review
    W van Dorp
    Division of Reproductive Medicine, Department of Obstetrics and Gynaecology, Erasmus MC University Medical Center Rotterdam, The Netherlands
    Hum Reprod Update 18:12-28. 2012
  6. ncbi request reprint [Resuscitation of a pregnant patient--don't hesitate to perform a perimortem caesarean section]
    Wendy van Dorp
    Maasstad Ziekenhuis, locaties Zuider en Clara, afd Gynaecologie en Obstetrie, Rotterdam, The Netherlands
    Ned Tijdschr Geneeskd 154:A2370. 2010
  7. doi request reprint EVI1 overexpression in distinct subtypes of pediatric acute myeloid leukemia
    B V Balgobind
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Leukemia 24:942-9. 2010
  8. doi request reprint Final height and IGF1 in adult survivors of Wilms tumour
    K Blijdorp
    Department of Paediatric Oncology Haematology, Erasmus Medical Center Sophia Children s Hospital, Rotterdam, PO Box 2060, 3000 CB Rotterdam, The Netherlands
    Eur J Endocrinol 169:445-51. 2013
  9. doi request reprint Endocrine late sequelae in long-term survivors of childhood non-Hodgkin lymphoma
    M van Waas
    Department of Pediatric Oncology Hematology, Erasmus Medical Center, Rotterdam, The Netherlands
    Ann Oncol 23:1626-32. 2012
  10. doi request reprint Hypermethylation of specific microRNA genes in MLL-rearranged infant acute lymphoblastic leukemia: major matters at a micro scale
    D J P M Stumpel
    Department of Pediatric Oncology Hematology, Erasmus Medical Center, Sophia Children s Hospital, Rotterdam, The Netherlands
    Leukemia 25:429-39. 2011

Detail Information

Publications64

  1. doi request reprint Pregnancy outcome of non-anonymous oocyte donation: a case-control study
    Wendy van Dorp
    Department of Gynaecology and Obstetrics, Division Reproductive Medicine, Erasmus MC University Medical Centre Rotterdam, s Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands Department of Paediatric Oncology Haematology, Erasmus MC Sophia Children s Hospital, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands Electronic address
    Eur J Obstet Gynecol Reprod Biol 182:107-12. 2014
    ....
  2. doi request reprint Decreased ovarian function is associated with obesity in very long-term female survivors of childhood cancer
    W van Dorp
    Department of Paediatric Oncology Haematology, Erasmus MC Sophia Children s Hospital, Dr Molewaterplein 60, 3015 GJ, Rotterdam, The Netherlands
    Eur J Endocrinol 168:905-12. 2013
    ..In the general population, obesity has a negative influence on female fertility. We aimed to evaluate whether obesity and serum insulin are associated with decreased ovarian reserve markers in CCS...
  3. doi request reprint Genetic variation may modify ovarian reserve in female childhood cancer survivors
    W van Dorp
    Department of Paediatric Oncology Haematology, ErasmusMC University Medical Centre Sophia s Children s Hospital Rotterdam, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands
    Hum Reprod 28:1069-76. 2013
    ..Are genetic polymorphisms, previously identified as being associated with age at menopause in the healthy population, associated with ovarian reserve and predicted age at menopause in adult long-term survivors of childhood cancer?..
  4. doi request reprint Gonadal function recovery in very long-term male survivors of childhood cancer
    Wendy van Dorp
    Department of Paediatric Oncology Haematology, Erasmus MC Sophia Children s Hospital, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands
    Eur J Cancer 49:1280-6. 2013
    ....
  5. doi request reprint Long-term endocrine side effects of childhood Hodgkin's lymphoma treatment: a review
    W van Dorp
    Division of Reproductive Medicine, Department of Obstetrics and Gynaecology, Erasmus MC University Medical Center Rotterdam, The Netherlands
    Hum Reprod Update 18:12-28. 2012
    ..The knowledge obtained in specific follow-up programmes for paediatric cancer survivors will help to find the optimal balance between curability and long-term side effects...
  6. ncbi request reprint [Resuscitation of a pregnant patient--don't hesitate to perform a perimortem caesarean section]
    Wendy van Dorp
    Maasstad Ziekenhuis, locaties Zuider en Clara, afd Gynaecologie en Obstetrie, Rotterdam, The Netherlands
    Ned Tijdschr Geneeskd 154:A2370. 2010
    ..Training should increase knowledge of the aforementioned changes and stress the importance of performing a perimortem caesarean section, when necessary, on site and without hesitation...
  7. doi request reprint EVI1 overexpression in distinct subtypes of pediatric acute myeloid leukemia
    B V Balgobind
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Leukemia 24:942-9. 2010
    ..Further research should explain the role of EVI1+ in disease biology in these cases. Remarkably, no 3q26 abnormalities were identified in EVI1+ pediatric AML...
  8. doi request reprint Final height and IGF1 in adult survivors of Wilms tumour
    K Blijdorp
    Department of Paediatric Oncology Haematology, Erasmus Medical Center Sophia Children s Hospital, Rotterdam, PO Box 2060, 3000 CB Rotterdam, The Netherlands
    Eur J Endocrinol 169:445-51. 2013
    ..The aim was to evaluate final height and IGF1 levels in nephrectomized Wilms tumour survivors when compared with healthy Dutch references and survivors of other cancer types...
  9. doi request reprint Endocrine late sequelae in long-term survivors of childhood non-Hodgkin lymphoma
    M van Waas
    Department of Pediatric Oncology Hematology, Erasmus Medical Center, Rotterdam, The Netherlands
    Ann Oncol 23:1626-32. 2012
    ..Aim of this study was to investigate the long-term endocrine effects of treatment of childhood non-Hodgkin lymphoma (NHL)...
  10. doi request reprint Hypermethylation of specific microRNA genes in MLL-rearranged infant acute lymphoblastic leukemia: major matters at a micro scale
    D J P M Stumpel
    Department of Pediatric Oncology Hematology, Erasmus Medical Center, Sophia Children s Hospital, Rotterdam, The Netherlands
    Leukemia 25:429-39. 2011
    ..In this study, we provide additional evidence that they should be tested for their efficacy in MLL-rearranged infant ALL in in vivo models...
  11. doi request reprint Prognostic significance of minimal residual disease in infants with acute lymphoblastic leukemia treated within the Interfant-99 protocol
    V H J van der Velden
    Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Leukemia 23:1073-9. 2009
    ..These data indicate that MRD diagnostics has added value for recognition of risk groups in infant ALL and that MRD diagnostics can be used for treatment intervention in infant ALL as well...
  12. ncbi request reprint Differential expression of p73 isoforms in relation to drug resistance in childhood T-lineage acute lymphoblastic leukaemia
    M Meier
    Department of Paediatric Oncology Haematology, Erasmus MC Sophia Children s Hospital, Erasmus University Medical Centre, Rotterdam, The Netherlands
    Leukemia 20:1377-84. 2006
    ..Our results suggest that childhood T-ALL is associated with a high expression of DeltaTA-p73. These isoforms may play a role in cellular resistance to DNA-damaging drugs in children at initial diagnosis of T-ALL...
  13. ncbi request reprint Prognostic significance of molecular-cytogenetic abnormalities in pediatric T-ALL is not explained by immunophenotypic differences
    M van Grotel
    Department of Pediatric Oncology Hematology, Erasmus University Medical Center Sophia Children s Hospital, Rotterdam, The Netherlands
    Leukemia 22:124-31. 2008
    ..Most cases with lower TAL1 levels were HOX11L2 or CALM-AF10 positive. NOTCH1 mutations did not predict for outcome. Classification into T-cell developmental subgroups was not predictive for outcome...
  14. doi request reprint Polymorphisms in genes involved in vincristine pharmacokinetics or pharmacodynamics are not related to impaired motor performance in children with leukemia
    A Hartman
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, PO Box 2060, 3000 CB Rotterdam, The Netherlands
    Leuk Res 34:154-9. 2010
    ..Impaired motor performance in children who completed treatment for acute lymphoblastic leukemia (ALL) may be related to polymorphisms of the metabolising gene CYP3A5 or vincristine toxicity related genes MDR-1 and MAPT...
  15. doi request reprint Components of the metabolic syndrome in 500 adult long-term survivors of childhood cancer
    M van Waas
    Department of Paediatric Oncology Haematology, Erasmus Medical Centre, Sophia Children s Hospital, Rotterdam, The Netherlands
    Ann Oncol 21:1121-6. 2010
    ..A cluster of abnormalities that contribute to the metabolic syndrome may be expressed at a higher level and therefore result in an increased risk for diabetes mellitus and cardiovascular diseases...
  16. ncbi request reprint MDR1 gene-related clonal selection and P-glycoprotein function and expression in relapsed or refractory acute myeloid leukemia
    M M van den Heuvel-Eibrink
    Department of Hematology, University Hospital, Rotterdam, The Netherlands
    Blood 97:3605-11. 2001
    ..Blood. 2001;97:3605-3611)..
  17. doi request reprint Cooperative genetic defects in TLX3 rearranged pediatric T-ALL
    P van Vlierberghe
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Leukemia 22:762-70. 2008
    ..This study provides a genome-wide overview of copy number changes in TLX3 rearranged T-ALL and offers great new challenges for the identification of new target genes that may play a role in the pathogenesis of T-ALL...
  18. doi request reprint High BRE expression in pediatric MLL-rearranged AML is associated with favorable outcome
    B V Balgobind
    Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Leukemia 24:2048-55. 2010
    ..Although further investigation for the role of BRE in leukemogenesis and outcome is warranted, high BRE expression is an independent prognostic factor for pRFS in pediatric AML...
  19. doi request reprint NOTCH1 and/or FBXW7 mutations predict for initial good prednisone response but not for improved outcome in pediatric T-cell acute lymphoblastic leukemia patients treated on DCOG or COALL protocols
    L Zuurbier
    Department of Pediatric Oncology Hematology, Sophia Children s Hospital, Erasmus University Medical Center, Rotterdam, The Netherlands
    Leukemia 24:2014-22. 2010
    ..Comparing our data with other studies, we conclude that the prognostic significance for NOTCH1/FBXW7 mutations is not consistent and may depend on the treatment protocol given...
  20. doi request reprint Bone mineral density after childhood cancer in 346 long-term adult survivors of childhood cancer
    M A H den Hoed
    Department of Paediatric Oncology Haematology, Erasmus University Medical Center Erasmus MC Sophia Children s Hospital, Dr Molewaterplein 60, 3015 GJ, Rotterdam, The Netherlands
    Osteoporos Int 26:521-9. 2015
    ..Our data suggest that greater awareness for osteopenia is warranted in long-term CCS, especially in survivors who are older than 30 years, male, and underweight and were treated with cranial-spinal radiotherapy and/or steroids...
  21. doi request reprint Germline variation in the MTHFR and MTRR genes determines the nadir of bone density in pediatric acute lymphoblastic leukemia: a prospective study
    M L te Winkel
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Bone 48:571-7. 2011
    ..This study aims to identify folate-metabolism-related genetic risk factors for low bone mineral density (BMD) during/after pediatric acute lymphoblastic leukemia (ALL) treatment...
  22. ncbi request reprint Silencing of the tumor suppressor gene FHIT is highly characteristic for MLL gene rearranged infant acute lymphoblastic leukemia
    R W Stam
    Erasmus MC Sophia Children s Hospital, Department of Pediatric Oncology Hematology, Rotterdam, The Netherlands
    Leukemia 20:264-71. 2006
    ..These observations imply that suppression of FHIT may be required for the development of MLL, and provide new insights into leukemogenesis and therapeutic possibilities for MLL...
  23. doi request reprint Altered expression of miR-24, miR-126 and miR-365 does not affect viability of childhood TCF3-rearranged leukemia cells
    F Akbari Moqadam
    Department of Pediatric Oncology and Hematology, Erasmus MC Sophia Children s Hospital, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Leukemia 28:1008-14. 2014
    ....
  24. doi request reprint Decreased serum anti-Müllerian hormone levels in girls with newly diagnosed cancer
    W van Dorp
    Division of Reproductive Medicine, Department of Obstetrics and Gynaecology, Erasmus MC University Medical Centre Rotterdam s Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    Hum Reprod 29:337-42. 2014
    ..Are anti-Müllerian hormone (AMH) levels reduced in girls with newly diagnosed cancer before the start of treatment?..
  25. doi request reprint Src kinase-induced phosphorylation of annexin A2 mediates glucocorticoid resistance in MLL-rearranged infant acute lymphoblastic leukemia
    J A P Spijkers-Hagelstein
    Department of Pediatric Oncology Haematology, Erasmus Medical Center Sophia Children s Hospital, Dr Molewaterplein 50, Rotterdam, The Netherlands
    Leukemia 27:1063-71. 2013
    ....
  26. doi request reprint MiR-125b, miR-100 and miR-99a co-regulate vincristine resistance in childhood acute lymphoblastic leukemia
    F Akbari Moqadam
    Department of Pediatric Oncology and Hematology, Erasmus MC Sophia Children s Hospital, University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Leuk Res 37:1315-21. 2013
    ..05). The concerted function of miR-125b in combination with miR-99a and/or miR-100 illustrates the complexity of vincristine-resistant pediatric ALL...
  27. pmc Aurora kinases in childhood acute leukemia: the promise of aurora B as therapeutic target
    S A Hartsink-Segers
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Leukemia 27:560-8. 2013
    ....
  28. doi request reprint Frequency of WT1 and 11p15 constitutional aberrations and phenotypic correlation in childhood Wilms tumour patients
    H Segers
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Eur J Cancer 48:3249-56. 2012
    ..Therefore, we investigated the frequency of constitutional aberrations in combination with phenotype...
  29. doi request reprint Discovery of new microRNAs by small RNAome deep sequencing in childhood acute lymphoblastic leukemia
    D Schotte
    Department of Pediatric Oncology and Hematology, Erasmus MC Sophia Children s Hospital, Erasmus University Medical Center, Rotterdam, The Netherlands
    Leukemia 25:1389-99. 2011
    ..36, P = 0.007). The identification of >1000 miR genes expressed in different types of ALL forms a comprehensive repository for further functional studies that address the role of miRNAs in the biology of ALL...
  30. ncbi request reprint A new recurrent 9q34 duplication in pediatric T-cell acute lymphoblastic leukemia
    P van Vlierberghe
    Erasmus MC Sophia Children s Hospital, Department of Pediatric Oncology Hematology, Rotterdam, The Netherlands
    Leukemia 20:1245-53. 2006
    ..We showed that both of these genetic abnormalities occur independently from this newly identified 9q34 duplication...
  31. doi request reprint Connectivity mapping identifies HDAC inhibitors for the treatment of t(4;11)-positive infant acute lymphoblastic leukemia
    D J P M Stumpel
    Department of Pediatric Oncology Hematology, Erasmus Medical Center, Sophia Children s Hospital, Rotterdam, The Netherlands
    Leukemia 26:682-92. 2012
    ..Given the presented potential of HDAC inhibitors to target important proto-oncogenes including the leukemia-specific MLL fusion in vitro, these agents should urgently be tested in in vivo models and subsequent clinical trials...
  32. ncbi request reprint Molecular pharmacodynamics in childhood leukemia
    R Pieters
    University Medical Center Rotterdam, Sophia Childrens Hospital, Pediatric Oncology Hematology, Rotterdam, The Netherlands
    Int J Hematol 78:402-13. 2003
  33. doi request reprint Chemical genomic screening identifies LY294002 as a modulator of glucocorticoid resistance in MLL-rearranged infant ALL
    J A P Spijkers-Hagelstein
    Department of Pediatric Oncology Hematology, Erasmus Medical Center Sophia Children s Hospital, Rotterdam, The Netherlands
    Leukemia 28:761-9. 2014
    ..Thus, implementing FDA-approved PI3K inhibitors in current treatments may potentially improve the GC response and prognosis in patients with MLL-rearranged ALL. ..
  34. doi request reprint NUP98/JARID1A is a novel recurrent abnormality in pediatric acute megakaryoblastic leukemia with a distinct HOX gene expression pattern
    J D E de Rooij
    Department of Pediatric Hematology Oncology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Leukemia 27:2280-8. 2013
    ..NUP98/JARID1A cases were characterized by HOXA/B gene overexpression, which is a potential druggable pathway. In conclusion, NUP98/JARID1A is a novel recurrent genetic abnormality in pediatric AMKL...
  35. doi request reprint Favorable prognostic impact of NPM1 gene mutations in childhood acute myeloid leukemia, with emphasis on cytogenetically normal AML
    I H I M Hollink
    Department of Pediatric Oncology and Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Leukemia 23:262-70. 2009
    ..However, in NPM1 wild-type CN-AML, FLT3/ITD-positive patients had a significantly worse outcome (pEFS 48 vs 18%; P<0.001). We conclude that NPM1 mutations confer a favorable prognosis in childhood AML and in CN-AML in particular...
  36. ncbi request reprint Incidence of additional genetic changes in the TEL and AML1 genes in DCOG and COALL-treated t(12;21)-positive pediatric ALL, and their relation with drug sensitivity and clinical outcome
    W A G Stams
    Erasmus MC, Sophia Children s Hospital, Erasmus University Medical Center Rotterdam, Division of Pediatric Oncology Hematology, Rotterdam, The Netherlands
    Leukemia 20:410-6. 2006
    ..78, 95% CI 1.45-23.0; P=0.01) is an independent prognostic factor in DCOG- and COALL-treated t(12;21)-positive ALL...
  37. doi request reprint Outcome in children with Down's syndrome and acute lymphoblastic leukemia: role of IKZF1 deletions and CRLF2 aberrations
    T D Buitenkamp
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Leukemia 26:2204-11. 2012
    ..05; P=0.001). Neither CRLF2 nor JAK2 were predictors for worse prognosis. If confirmed in prospective series, IKZF1 deletions may be used for risk-group stratification in DS ALL...
  38. doi request reprint The heterogeneity of pediatric MLL-rearranged acute myeloid leukemia
    B V Balgobind
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Leukemia 25:1239-48. 2011
    ..To achieve further improvements in outcome, unraveling the biology of MLL-rearranged pediatric AML is warranted...
  39. doi request reprint Identification of new microRNA genes and aberrant microRNA profiles in childhood acute lymphoblastic leukemia
    D Schotte
    Department of Pediatric Oncology and Hematology, Erasmus MC Sophia Children s Hospital, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Leukemia 23:313-22. 2009
    ..In conclusion, we identified new miRNA genes and showed that miRNA expression profiles are ALL subtype-specific rather than linked to the differentiation stadium associated with these subtypes...
  40. doi request reprint NKL homeobox genes in leukemia
    I Homminga
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Leukemia 26:572-81. 2012
    ..Identification of a potential common leukemogenic NKL downstream pathway will provide a promising subject for future studies...
  41. doi request reprint MicroRNAs in acute leukemia: from biological players to clinical contributors
    D Schotte
    Department of Pediatric Oncology and Hematology, Erasmus MC Sophia Children s Hospital, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Leukemia 26:1-12. 2012
    ..However, emerging knowledge about the biology of miRNAs in leukemia may result into a role for these miRNAs in the diagnosis and treatment of acute leukemia...
  42. doi request reprint Genetic and metabolic determinants of methotrexate-induced mucositis in pediatric acute lymphoblastic leukemia
    M A H den Hoed
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Pharmacogenomics J 15:248-54. 2015
    ..016). We found no evidence that erythrocyte folate levels mediate in the association between the rs7317112 and mucositis...
  43. pmc PKCζ and PKMζ are overexpressed in TCF3-rearranged paediatric acute lymphoblastic leukaemia and are associated with increased thiopurine sensitivity
    S A Hartsink-Segers
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Leukemia 29:304-11. 2015
    ..Collectively, our data indicate that thiopurine treatment may be effective, especially in paediatric TCF3-rearranged ALL and other patients with a high expression of PKC/Mζ. ..
  44. doi request reprint Gain of 1q is a marker of poor prognosis in Wilms' tumors
    H Segers
    Department of Pediatric Oncology Hematology, Erasmus MC, Sophia Children s Hospital, Rotterdam, 3015, GJ, The Netherlands
    Genes Chromosomes Cancer 52:1065-74. 2013
    ..Confirmation in other studies is necessary before future therapeutic studies can incorporate 1q gain into new risk stratification schema...
  45. doi request reprint Pharmacokinetic, pharmacodynamic and intracellular effects of PEG-asparaginase in newly diagnosed childhood acute lymphoblastic leukemia: results from a single agent window study
    I M Appel
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Erasmus University Medical Center, Rotterdam, The Netherlands
    Leukemia 22:1665-79. 2008
    ..This may be explained by the rapid removal of apoptotic cells from the circulation in vivo. One additional dose of PEG-asparaginase upfront ALL treatment did not lead to other severe toxicities...
  46. doi request reprint Improved flow cytometric detection of minimal residual disease in childhood acute lymphoblastic leukemia
    B Denys
    Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Leukemia 27:635-41. 2013
    ..In conclusion, 6-color FCM significantly improves MRD analysis in ALL but remains less sensitive than PCR-based MRD-diagnostics...
  47. doi request reprint The hunting of targets: challenge in miRNA research
    F Akbari Moqadam
    Department of Pediatric Oncology and Hematology, Erasmus MC Sophia Children s Hospital, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Leukemia 27:16-23. 2013
    ....
  48. ncbi request reprint MDR1 expression in poor-risk acute myeloid leukemia with partial or complete monosomy 7
    M M van den Heuvel-Eibrink
    Department of Hematology, University Hospital and Erasmus University, Rotterdam, The Netherlands
    Leukemia 15:398-405. 2001
    ..We conclude that MDR1 expression in -7/7q- AML patients is upregulated at transcriptional, but not at translational level, suggesting that mechanisms other than MDR1 are responsible for the poor prognosis in these patients...
  49. doi request reprint A randomized trial investigating an exercise program to prevent reduction of bone mineral density and impairment of motor performance during treatment for childhood acute lymphoblastic leukemia
    A Hartman
    Department of Paediatric Oncology Haematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Pediatr Blood Cancer 53:64-71. 2009
    ..We performed a randomized study investigating whether an exercise program could prevent these side effects...
  50. ncbi request reprint Relation between genetic variants of the ataxia telangiectasia-mutated (ATM) gene, drug resistance, clinical outcome and predisposition to childhood T-lineage acute lymphoblastic leukaemia
    M Meier
    Department of Paediatric Oncology Haematology, Erasmus MC Sophia Children s Hospital, Erasmus University Medical Centre, Rotterdam, The Netherlands
    Leukemia 19:1887-95. 2005
    ..05). The association between five coding ATM alterations in T-ALL, their germline presence, white blood cell count and unfavourable outcome may point to a role for ATM in the development of T-ALL in these children...
  51. doi request reprint Posterior reversible encephalopathy syndrome in childhood cancer
    P de Laat
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, University Medical Center, Rotterdam, The Netherlands
    Ann Oncol 22:472-8. 2011
    ..Posterior reversible encephalopathy syndrome (PRES) is characterized by seizures, headaches, altered mental status, cortical blindness and typical transient lesions on magnetic resonance imaging...
  52. doi request reprint Prognostic value of rare IKZF1 deletion in childhood B-cell precursor acute lymphoblastic leukemia: an international collaborative study
    J M Boer
    Department of Pediatric Oncology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Leukemia 30:32-8. 2016
    ..We therefore conclude that all variants of rare IKZF1 deletions are associated with an unfavorable prognosis in pediatric BCP-ALL. ..
  53. doi request reprint EMP1, a novel poor prognostic factor in pediatric leukemia regulates prednisolone resistance, cell proliferation, migration and adhesion
    I M Ariës
    Department of Pediatric Oncology Hematology, Erasmus Medical Center Sophia Children s Hospital, Rotterdam, The Netherlands
    Leukemia 28:1828-37. 2014
    ..004, hazard ratio: 2.36 (1.31-4.25). This study provides preclinical evidence that EMP1 is an interesting candidate for drug development to optimize treatment of BCP-ALL...
  54. doi request reprint Myocyte enhancer factor 2C in hematopoiesis and leukemia
    K Canté-Barrett
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Oncogene 33:403-10. 2014
    ..This review focuses on the role of MEF2C in the hematopoietic system and on aberrant MEF2C expression in human leukemia. ..
  55. ncbi request reprint No adverse effect of vincristine on handwriting in children after completion of therapy
    A Hartman
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Pediatr Blood Cancer 49:841-5. 2007
    ..Long-term writing difficulties in children after treatment with vincristine for acute lymphoblastic leukemia, Wilms tumor, B non-Hodgkin lymphoma, and malignant mesenchymal tumors, were investigated...
  56. ncbi request reprint Immunobiological diversity in infant acute lymphoblastic leukemia is related to the occurrence and type of MLL gene rearrangement
    M W J C Jansen
    Department of Immunology, Erasmus MC, Rotterdam, The Netherlands
    Leukemia 21:633-41. 2007
    ..The high frequency of immature and oligoclonal Ig/TCR rearrangements is probably caused by early (prenatal) oncogenic transformation in immature B-lineage progenitor cells with germline Ig/TCR genes combined with a short latency period...
  57. doi request reprint T-cell receptor Vbeta CDR3 oligoclonality frequently occurs in childhood refractory cytopenia (MDS-RC) and severe aplastic anemia
    A C H de Vries
    Department of Pediatric Oncology Hematology, Erasmus University Medical Center Sophia Children s Hospital, Rotterdam, The Netherlands
    Leukemia 22:1170-4. 2008
    ..Prospective studies are required to establish the clinical value of TCR Vbeta CDR3 repertoire analysis to predict the clinical response in these patients...
  58. doi request reprint Self-limiting sternal tumors of childhood (SELSTOC)
    M L te Winkel
    Department of Pediatric Oncology Hematology, Erasmus MC, Sophia Children s Hospital, Rotterdam, The Netherlands
    Pediatr Blood Cancer 55:81-4. 2010
    ..Because a sternal mass is often alarming, it is important to identify the clinical features of benign processes...
  59. doi request reprint Does dexamethasone induce more neuropsychological side effects than prednisone in pediatric acute lymphoblastic leukemia? A systematic review
    L T Warris
    Department of Pediatric Hematology and Oncology, Erasmus MC Sophia Children s Hospital, Rotterdam, the Netherlands Department of Pediatric Endocrinology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Pediatr Blood Cancer 61:1313-8. 2014
    ..Randomized controlled trials with neuropsychological function as the primary or secondary outcome did not show clinically meaningful differences between dexamethasone and prednisone on cognition, mood or behavior...
  60. pmc T-cell receptor Vβ skewing frequently occurs in refractory cytopenia of childhood and is associated with an expansion of effector cytotoxic T cells: a prospective study by EWOG-MDS
    A M Aalbers
    1 Department of Pediatric Oncology Hematology, Sophia Children s Hospital Erasmus University Medical Center, Rotterdam, The Netherlands 2 Department of Immunology, Erasmus MC, Erasmus University Medical Center, Rotterdam, The Netherlands
    Blood Cancer J 4:e209. 2014
    ..These data suggest that T lymphocytes contribute to RCC pathogenesis in a proportion of patients, and provide a rationale for treatment with IST in selected patients with RCC. ..
  61. ncbi request reprint Renin-induced hypertension in Wilms tumor patients
    M H Maas
    Department of Pediatric Oncology Hematology, Erasmus MC, Sophia Children s Hospital, Rotterdam, The Netherlands
    Pediatr Blood Cancer 48:500-3. 2007
    ..The purpose of this study was to investigate the correlation between plasma renin levels and blood pressure in a larger cohort of WT patients...
  62. ncbi request reprint The clinical value of follow-up examinations in childhood T-cell acute lymphoblastic leukemia and T-cell non-Hodgkin's lymphoma
    L Huang
    Department of Pediatric Hemato Oncology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Pediatr Blood Cancer 48:468-72. 2007
    ....
  63. ncbi request reprint L-asparaginase-induced severe necrotizing pancreatitis successfully treated with percutaneous drainage
    P C Top
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Pediatr Blood Cancer 44:95-7. 2005
    ..We present a pediatric patient with leukemia and a severe, L-asparaginase-induced necrotizing pancreatitis, treated successfully with percutaneous drainage used to flush the infected necrotic parts...
  64. ncbi request reprint Multidrug resistance genes in infant acute lymphoblastic leukemia: Ara-C is not a substrate for the breast cancer resistance protein
    R W Stam
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Leukemia 18:78-83. 2004
    ..8/T6400, also did not modulate Ara-C cytotoxicity. Therefore, we conclude that Ara-C is not a substrate for BCRP and that MDR proteins do not play a significant role in drug resistance in infant ALL...