Caroline C W Klaver

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. pmc Clinical course of cone dystrophy caused by mutations in the RPGR gene
    Alberta A H J Thiadens
    Department of Ophthalmology, Erasmus Medical Center, PO Box 2040, 3000, CA, Rotterdam, The Netherlands
    Graefes Arch Clin Exp Ophthalmol 249:1527-35. 2011
  2. pmc Education influences the role of genetics in myopia
    Virginie J M Verhoeven
    Department of Ophthalmology, Erasmus Medical Center, Room Na 2808, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Epidemiol 28:973-80. 2013
  3. doi request reprint Comprehensive analysis of the achromatopsia genes CNGA3 and CNGB3 in progressive cone dystrophy
    Alberta A H J Thiadens
    Department of Ophthalmology, Erasmus Medical Centre, Rotterdam, The Netherlands
    Ophthalmology 117:825-30.e1. 2010
  4. ncbi request reprint Usefulness of combining complement factor H and C-reactive protein genetic profiles for predicting myocardial infarction (from the Rotterdam Study)
    Isabella Kardys
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Cardiol 100:646-8. 2007
  5. doi request reprint Clinical course, genetic etiology, and visual outcome in cone and cone-rod dystrophy
    Alberta A H J Thiadens
    Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands
    Ophthalmology 119:819-26. 2012
  6. doi request reprint Clinical implications of old and new genes for open-angle glaucoma
    Wishal D Ramdas
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Ophthalmology 118:2389-97. 2011
  7. doi request reprint Reducing the genetic risk of age-related macular degeneration with dietary antioxidants, zinc, and ω-3 fatty acids: the Rotterdam study
    Lintje Ho
    Department of Ophthalmology, Erasmus Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands
    Arch Ophthalmol 129:758-66. 2011
  8. ncbi request reprint Complement factor H polymorphism, complement activators, and risk of age-related macular degeneration
    Dominiek D G Despriet
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    JAMA 296:301-9. 2006
  9. ncbi request reprint Complement component C3 and risk of age-related macular degeneration
    Dominiek D G Despriet
    Department of Epidemiology and Biostatistics, Rotterdam, Erasmus Medical Centre, The Netherlands
    Ophthalmology 116:474-480.e2. 2009
  10. doi request reprint Risk alleles in CFH and ARMS2 are independently associated with systemic complement activation in age-related macular degeneration
    Dzenita Smailhodzic
    Department of Ophthalmology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Ophthalmology 119:339-46. 2012

Detail Information

Publications43

  1. pmc Clinical course of cone dystrophy caused by mutations in the RPGR gene
    Alberta A H J Thiadens
    Department of Ophthalmology, Erasmus Medical Center, PO Box 2040, 3000, CA, Rotterdam, The Netherlands
    Graefes Arch Clin Exp Ophthalmol 249:1527-35. 2011
    ..Mutations in the RPGR gene predominantly cause rod photoreceptor disorders with a large variability in clinical course. In this report, we describe two families with mutations in this gene and cone involvement...
  2. pmc Education influences the role of genetics in myopia
    Virginie J M Verhoeven
    Department of Ophthalmology, Erasmus Medical Center, Room Na 2808, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Epidemiol 28:973-80. 2013
    ..2, 95 % CI 1.9-9.5). This epidemiological study provides evidence of a gene-environment interaction in which an individual's genetic risk of myopia is significantly affected by his or her educational level...
  3. doi request reprint Comprehensive analysis of the achromatopsia genes CNGA3 and CNGB3 in progressive cone dystrophy
    Alberta A H J Thiadens
    Department of Ophthalmology, Erasmus Medical Centre, Rotterdam, The Netherlands
    Ophthalmology 117:825-30.e1. 2010
    ..To investigate whether the major achromatopsia genes (CNGA3 and CNGB3) play a role in the cause of progressive cone dystrophy (CD)...
  4. ncbi request reprint Usefulness of combining complement factor H and C-reactive protein genetic profiles for predicting myocardial infarction (from the Rotterdam Study)
    Isabella Kardys
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Cardiol 100:646-8. 2007
    ..1 to 16.5) to develop MI compared with the reference group. In conclusion, this population-based study suggests that the combined presence of unfavorable CFH and CRP genetic profiles is associated with risk of MI...
  5. doi request reprint Clinical course, genetic etiology, and visual outcome in cone and cone-rod dystrophy
    Alberta A H J Thiadens
    Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands
    Ophthalmology 119:819-26. 2012
    ..To evaluate the clinical course, genetic etiology, and visual prognosis in patients with cone dystrophy (CD) and cone-rod dystrophy (CRD)...
  6. doi request reprint Clinical implications of old and new genes for open-angle glaucoma
    Wishal D Ramdas
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Ophthalmology 118:2389-97. 2011
    ..This study was performed to determine to what extent variants within established genes (MYOC, OPTN, and WDR36) and newly identified common genetic variants (ATOH7, CDKN2B, and SIX1) contribute to the risk of OAG...
  7. doi request reprint Reducing the genetic risk of age-related macular degeneration with dietary antioxidants, zinc, and ω-3 fatty acids: the Rotterdam study
    Lintje Ho
    Department of Ophthalmology, Erasmus Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands
    Arch Ophthalmol 129:758-66. 2011
    ..To investigate whether dietary nutrients can reduce the genetic risk of early age-related macular degeneration (AMD) conferred by the genetic variants CFH Y402H and LOC387715 A69S in a nested case-control study...
  8. ncbi request reprint Complement factor H polymorphism, complement activators, and risk of age-related macular degeneration
    Dominiek D G Despriet
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    JAMA 296:301-9. 2006
    ..Recent case-control studies demonstrated an association between the complement factor H (CFH) gene, a regulator of complement, and AMD...
  9. ncbi request reprint Complement component C3 and risk of age-related macular degeneration
    Dominiek D G Despriet
    Department of Epidemiology and Biostatistics, Rotterdam, Erasmus Medical Centre, The Netherlands
    Ophthalmology 116:474-480.e2. 2009
    ..To explore the association between polymorphisms in the complement component 3 (C3) gene and age-related macular degeneration (AMD), and to investigate the modifying effect of complement factor H (CFH) Y402H, LOC387715 A69S and smoking...
  10. doi request reprint Risk alleles in CFH and ARMS2 are independently associated with systemic complement activation in age-related macular degeneration
    Dzenita Smailhodzic
    Department of Ophthalmology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Ophthalmology 119:339-46. 2012
    ....
  11. pmc Cone-rod dystrophy can be a manifestation of Danon disease
    Alberta A H J Thiadens
    Department of Ophthalmology, Erasmus Medical Center, P O Box 2040, NL 3000 CA, Rotterdam, Netherlands
    Graefes Arch Clin Exp Ophthalmol 250:769-74. 2012
    ..Danon disease is a neuromuscular disorder with variable expression in the eye. We describe a family with Danon disease and cone-rod dystrophy (CRD)...
  12. doi request reprint A novel nonsense mutation in CEP290 induces exon skipping and leads to a relatively mild retinal phenotype
    Karin W Littink
    Rotterdam Eye Hospital, Rotterdam, The Netherlands
    Invest Ophthalmol Vis Sci 51:3646-52. 2010
    ..The additional heterozygous mutation in MERTK may clarify the more severe phenotype in the proband. This study extends the phenotypic spectrum of CEP290-associated diseases at the mild end...
  13. ncbi request reprint Clinical evaluation of 3 families with basal laminar drusen caused by novel mutations in the complement factor H gene
    Johannes P H van de Ven
    Department of Ophthalmology, Radboud University Medical Center, Philips van Leydenlaan, 6525 EX Nijmegen, The Netherlands
    Arch Ophthalmol 130:1038-47. 2012
    ..To identify novel complement factor H (CFH) gene mutations and to specify the clinical characteristics in patients with basal laminar drusen (BLD), a clinical subtype of age-related macular degeneration...
  14. doi request reprint The Rotterdam Study: 2014 objectives and design update
    Albert Hofman
    Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Epidemiol 28:889-926. 2013
    ..erasmus-epidemiology.nl/rotterdamstudy ). This article gives the rationale of the study and its design. It also presents a summary of the major findings and an update of the objectives and methods...
  15. doi request reprint Genetic etiology and clinical consequences of complete and incomplete achromatopsia
    Alberta A H J Thiadens
    Department of Ophthalmology, Erasmus Medical Centre, Rotterdam, The Netherlands
    Ophthalmology 116:1984-9.e1. 2009
    ..To investigate the genetic causes of complete and incomplete achromatopsia (ACHM) and assess the association between disease-causing mutations, phenotype at diagnosis, and visual prognosis...
  16. doi request reprint Common genetic variants associated with open-angle glaucoma
    Wishal D Ramdas
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Hum Mol Genet 20:2464-71. 2011
    ..These findings may shed new light on the pathophysiological protein pathways leading to glaucoma, and point to pathways involved in the growth and development of the optic nerve...
  17. ncbi request reprint A common polymorphism in the complement factor H gene is associated with increased risk of myocardial infarction: the Rotterdam Study
    Isabella Kardys
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    J Am Coll Cardiol 47:1568-75. 2006
    ..This study was designed to investigate the association between a common polymorphism (Tyr402His, rs1061170) in the complement factor H (CFH) gene and risk of coronary heart disease...
  18. doi request reprint A genetic epidemiologic study of candidate genes involved in the optic nerve head morphology
    Andrea C Gasten
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Invest Ophthalmol Vis Sci 53:1485-91. 2012
    ..The purpose of the present study was to investigate whether genes encoding protein known to interact with protein encoded by SALL1 and SIX1 are also associated with either DA or VCDR...
  19. doi request reprint Progressive loss of cones in achromatopsia: an imaging study using spectral-domain optical coherence tomography
    Alberta A H J Thiadens
    Department of Ophthalmology, Erasmus Medical Centre, Rotterdam, The Netherlands
    Invest Ophthalmol Vis Sci 51:5952-7. 2010
    ..Future implementation of this therapy in humans requires the presence of viable cone cells in the retina. In this study the presence of cone cells in ACHM was determined, as a function of age...
  20. pmc Optimizing the information yield of 3-D OCT in glaucoma
    Henriët Springelkamp
    Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands
    Invest Ophthalmol Vis Sci 53:8162-71. 2012
    ....
  21. doi request reprint Accuracy of four commonly used color vision tests in the identification of cone disorders
    Alberta A H J Thiadens
    Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands
    Ophthalmic Epidemiol 20:114-21. 2013
    ..To determine which color vision test is most appropriate for the identification of cone disorders...
  22. doi request reprint Association of cognitive functioning with retinal nerve fiber layer thickness
    Leonieke M E van Koolwijk
    Glaucoma Service, The Rotterdam Eye Hospital, Rotterdam, The Netherlands
    Invest Ophthalmol Vis Sci 50:4576-80. 2009
    ..The association between cognitive functioning and retinal nerve fiber layer (RNFL) thickness was assessed in a large, population-based sample...
  23. doi request reprint Genetic architecture of open angle glaucoma and related determinants
    Wishal D Ramdas
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Med Genet 48:190-6. 2011
    ..We evaluated whether the same genes that determine VCDR and IOP also predict OAG...
  24. ncbi request reprint Dietary intake of antioxidants and risk of age-related macular degeneration
    Redmer van Leeuwen
    Department of Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands
    JAMA 294:3101-7. 2005
    ..Recently, high-dose supplementation with beta carotene, vitamins C and E, and zinc was shown to slow the progression of AMD...
  25. pmc Common genetic determinants of intraocular pressure and primary open-angle glaucoma
    Leonieke M E van Koolwijk
    Glaucoma Service, The Rotterdam Eye Hospital, Rotterdam, The Netherlands
    PLoS Genet 8:e1002611. 2012
    ..Both genes functionally interact with known glaucoma disease genes. These data suggest that we have identified two clinically relevant genes involved in IOP regulation...
  26. doi request reprint A functional variant in the CFI gene confers a high risk of age-related macular degeneration
    Johannes P H van de Ven
    Department of Ophthalmology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Nat Genet 45:813-7. 2013
    ..Taken together, these findings demonstrate that rare, highly penetrant mutations contribute to the genetic burden of AMD...
  27. pmc Homozygosity mapping reveals PDE6C mutations in patients with early-onset cone photoreceptor disorders
    Alberta A H J Thiadens
    Department of Ophthalmology, Erasmus Medical Centre, Rotterdam, The Netherlands
    Am J Hum Genet 85:240-7. 2009
    ..Our findings identify PDE6C as a gene for cone photoreceptor disorders and show that arCD and ACHM constitute genetically and clinically overlapping phenotypes...
  28. ncbi request reprint Genetic contributions to glaucoma: heritability of intraocular pressure, retinal nerve fiber layer thickness, and optic disc morphology
    Leonieke M E van Koolwijk
    Glaucoma Service, The Rotterdam Eye Hospital, Rotterdam, The Netherlands
    Invest Ophthalmol Vis Sci 48:3669-76. 2007
    ....
  29. pmc Prediction of age-related macular degeneration in the general population: the Three Continent AMD Consortium
    Gabriëlle H S Buitendijk
    Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Ophthalmology 120:2644-55. 2013
    ..The aim of this study is to develop a prediction model for late AMD based on data from population-based studies...
  30. doi request reprint The spectrum of phenotypes caused by variants in the CFH gene
    Camiel J F Boon
    Department of Ophthalmology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Mol Immunol 46:1573-94. 2009
    ..The phenotypic outcome of these CFH variants depends on their differential impact on plasma- and surface-bound CFH function. Consequently, distinct genotype-phenotype correlations may be observed...
  31. pmc A genome-wide association study of optic disc parameters
    Wishal D Ramdas
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS Genet 6:e1000978. 2010
    ..Three of the loci were marginally associated with open-angle glaucoma. The protein pathways in which the loci of optic disc area are involved overlap with those identified for VCDR, suggesting a common genetic origin...
  32. doi request reprint A genome-wide association study identifies a susceptibility locus for refractive errors and myopia at 15q14
    Abbas M Solouki
    Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands
    Nat Genet 42:897-901. 2010
    ..Our data suggest that common variants at 15q14 influence susceptibility for refractive errors in the general population...
  33. ncbi request reprint Cholesterol and age-related macular degeneration: is there a link?
    Redmer van Leeuwen
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Ophthalmol 137:750-2. 2004
    ..To examine the relation among serum cholesterol, apolipoprotein E genotype (APOE), and the risk of early and late age-related macular degeneration (AMD)...
  34. pmc The Rotterdam Study: 2012 objectives and design update
    Albert Hofman
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Epidemiol 26:657-86. 2011
    ..erasmus-epidemiology.nl/rotterdamstudy ). This article gives the rationale of the study and its design. It also presents a summary of the major findings and an update of the objectives and methods...
  35. ncbi request reprint Epidemiology of age-related maculopathy: a review
    Redmer van Leeuwen
    Department of Epidemiology and Biostatistics, Erasmus Medical Centre, Rotterdam, The Netherlands
    Eur J Epidemiol 18:845-54. 2003
    ..Future studies, both observational and experimental, will hopefully identify more risk factors that are amenable to prevention...
  36. pmc Large scale international replication and meta-analysis study confirms association of the 15q14 locus with myopia. The CREAM consortium
    Virginie J M Verhoeven
    Department of Ophthalmology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    Hum Genet 131:1467-80. 2012
    ..SNPs at locus 15q25 did not replicate significantly (P value 5.81 × 10(-2) for top SNP rs939661). We conclude that common variants at chromosome 15q14 influence susceptibility for myopia in Caucasian and Asian populations world-wide...
  37. pmc Analysis of rare variants in the C3 gene in patients with age-related macular degeneration
    Maheswara R Duvvari
    Department of Ophthalmology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 9:e94165. 2014
    ..The Lys65Gln variant was only identified in patients from Nijmegen, the Netherlands, and thus may represent a region-specific AMD risk variant...
  38. pmc Three genome-wide association studies and a linkage analysis identify HERC2 as a human iris color gene
    Manfred Kayser
    Department of Forensic Molecular Biology, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands
    Am J Hum Genet 82:411-23. 2008
    ..Testing markers in the HERC2-OCA2 region may be useful in forensic applications to predict eye color phenotypes of unknown persons of European genetic origin...
  39. ncbi request reprint IMPG2-Associated Retinitis Pigmentosa Displays Relatively Early Macular Involvement
    Ramon A C van Huet
    Department of Ophthalmology, Radboud University Medical Center, Nijmegen, The Netherlands
    Invest Ophthalmol Vis Sci 55:3939-53. 2014
    ..To provide the first detailed clinical description in patients with RP caused by recessive mutations in IMPG2...
  40. ncbi request reprint Prevalence of amblyopia and refractive errors in an unscreened population of children
    Jan Roelof Polling
    Department of Ophthalmology, Erasmus MC, Rotterdam, The Netherlands
    Optom Vis Sci 89:e44-9. 2012
    ..To describe the frequency of refractive errors and amblyopia in unscreened children aged 2 months to 12 years from a rural town in Poland...
  41. ncbi request reprint The risk and natural course of age-related maculopathy: follow-up at 6 1/2 years in the Rotterdam study
    Redmer van Leeuwen
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Arch Ophthalmol 121:519-26. 2003
    ..To evaluate the natural course of age-related maculopathy (ARM) and to assess the incidence and absolute risk of its final stage, age-related macular degeneration (AMD)...
  42. ncbi request reprint Genetic risk of rhegmatogenous retinal detachment: a familial aggregation study
    Sioe Lie Go
    Department of Ophthalmology, University Medical Centre Nijmegen, 6500 HB Nijmegen, The Netherlands
    Arch Ophthalmol 123:1237-41. 2005
    ..To investigate the magnitude of the genetic risk of nonsyndromic rhegmatogenous retinal detachments (RRDs) in a familial aggregation study...
  43. pmc Macrophages feel their age in macular degeneration
    Martine J Jager
    Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
    J Clin Invest 117:3182-4. 2007
    ..These data provide insight into the effect of senescence on macrophage function and angiogenesis and have important implications for age-related diseases such as macular degeneration...