Affiliation: Erasmus University
Country: The Netherlands
- The G-protein gamma subunit gpc-1 of the nematode C.elegans is involved in taste adaptationGert Jansen
MGC Department of Cell Biology and Genetics and Centre for Biomedical Genetics, Erasmus University Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
EMBO J 21:986-94. 2002..Our finding that G proteins, OSM-9 and ADP-1 are involved in taste adaptation offer the first molecular insight into this process...
- Noncell- and cell-autonomous G-protein-signaling converges with Ca2+/mitogen-activated protein kinase signaling to regulate str-2 receptor gene expression in Caenorhabditis elegansHannes Lans
MGC Department of Cell Biology and Genetics, Center for Biomedical Genetics, Erasmus MC, 3000 DR Rotterdam, The Netherlands
Genetics 173:1287-99. 2006..Our results reveal a complex signaling network, encompassing signals from multiple cells, that controls the level of receptor gene expression at different developmental stages...
- A network of stimulatory and inhibitory Galpha-subunits regulates olfaction in Caenorhabditis elegansHannes Lans
MGC Department of Cell Biology and Genetics, Center for Biomedical Genetics, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands
Genetics 167:1677-87. 2004..Defects in this process are, however, independent of olfactory behavior. Our findings reveal the existence of a complex signaling network that controls odorant detection by C. elegans...
- Antagonistic sensory cues generate gustatory plasticity in Caenorhabditis elegansRenate K Hukema
MGC Department of Cell Biology and Genetics, Centre for Biomedical Genetics, Erasmus MC, Rotterdam, The Netherlands
EMBO J 25:312-22. 2006..Finally, the response to NaCl is modulated by G-protein signalling in the ASI and ADF neurons, a second G-protein pathway in ASH and cGMP signalling in neurons exposed to the body fluid...
- Multiple sensory G proteins in the olfactory, gustatory and nociceptive neurons modulate longevity in Caenorhabditis elegansHannes Lans
MGC Department of Cell Biology and Genetics, Center for Biomedical Genetics, Erasmus MC, 3000 CA Rotterdam, The Netherlands
Dev Biol 303:474-82. 2007..We expect that the implication of specific G proteins will eventually contribute to the identification of the sensory cues that determine the rate of aging in C. elegans...
- Expression of mammalian GPCRs in C. elegans generates novel behavioural responses to human ligandsMichelle S Teng
Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK
BMC Biol 4:22. 2006..We sought to test this by functionally expressing two medically important mammalian GPCRs, somatostatin receptor 2 (Sstr2) and chemokine receptor 5 (CCR5) in the gustatory neurons of C. elegans...
- G protein-coupled receptor kinase function is essential for chemosensation in C. elegansHana S Fukuto
Department of Biology, University of California, San Diego, La Jolla, CA 92093 USA
Neuron 42:581-93. 2004..These results demonstrate that loss of GRK function can lead to reduced GPCR signal transduction and suggest an important role for RGS proteins in the regulation of chemosensation...
- Mutation of the MAP kinase DYF-5 affects docking and undocking of kinesin-2 motors and reduces their speed in the cilia of Caenorhabditis elegansJan Burghoorn
Department of Cell Biology and Genetics, and Center for Biomedical Genetics, Erasmus Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands
Proc Natl Acad Sci U S A 104:7157-62. 2007..We propose that DYF-5 plays a role in the undocking of kinesin II from IFT particles and in the docking of OSM-3 onto IFT particles...
- Functional characterization of three G protein-coupled receptors for pigment dispersing factors in Caenorhabditis elegansTom Janssen
Functional Genomics and Proteomics Unit, Department of Biology, K U Leuven, Naamsestraat 59, Leuven, Belgium
J Biol Chem 283:15241-9. 2008..Our findings strengthen the hypothesis that the PDF signaling system, which imposes the circadian clock rhythm on behavior in Drosophila, has been functionally conserved throughout the protostomian evolutionary lineage...
- Control of feeding behavior in C. elegans by human G protein-coupled receptors permits screening for agonist-expressing bacteriaMichelle S Teng
Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire CB10 1HH, United Kingdom
Proc Natl Acad Sci U S A 105:14826-31. 2008..This approach serves not only for structure/function studies as demonstrated, but may be used to facilitate the discovery of agonists within bacterial libraries...