Frank J H Gijsen

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. ncbi Shear stress, vascular remodeling and neointimal formation
    Jolanda J Wentzel
    Department of Cardiology, Thoraxcentre EE2322, Erasmus Medical Centre Rotterdam, Erasmus University Rotterdam, P O Box 1738, 3000 DR Rotterdam, Netherlands
    J Biomech 36:681-8. 2003
  2. ncbi A new imaging technique to study 3-D plaque and shear stress distribution in human coronary artery bifurcations in vivo
    Frank J H Gijsen
    Department of Biomedical Engineering, Thoraxcenter, Ee2322, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    J Biomech 40:2349-57. 2007
  3. doi Carotid Plaque Morphological Classification Compared With Biomechanical Cap Stress: Implications for a Magnetic Resonance Imaging-Based Assessment
    Frank J H Gijsen
    From the Departments of Biomedical Engineering Thoraxcenter F J H G, H A N, J J W, A F W v d S, Vascular Surgery H J M V, and Radiology A v d L, Erasmus MC, Rotterdam, The Netherlands and Department of Applied Sciences, Delft University of Technology, Delft, The Netherlands A F W v d S
    Stroke 46:2124-8. 2015
  4. doi 3D reconstruction techniques of human coronary bifurcations for shear stress computations
    Frank J H Gijsen
    Biomedical Engineering, Department of Cardiology, Erasmus MC, PO Box 2040, 3000 CA, Rotterdam, The Netherlands Electronic address
    J Biomech 47:39-43. 2014
  5. doi Shear stress and advanced atherosclerosis in human coronary arteries
    Frank Gijsen
    Department of Biomedical Engineering, Erasmus MC, Rotterdam, The Netherlands
    J Biomech 46:240-7. 2013
  6. pmc Effects of intima stiffness and plaque morphology on peak cap stress
    Ali C Akyildiz
    Department of Biomedical Engineering, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands
    Biomed Eng Online 10:25. 2011
  7. doi High shear stress induces a strain increase in human coronary plaques over a 6-month period
    Frank J H Gijsen
    Department of Biomedical Engineering, Thoraxcenter, ErasmusMC, Rotterdam, The Netherlands
    EuroIntervention 7:121-7. 2011
  8. pmc Simulation of stent deployment in a realistic human coronary artery
    Frank J H Gijsen
    Department of Biomedical Engineering, Thoraxcentre EE2322, Erasmus Medical Center Rotterdam, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Biomed Eng Online 7:23. 2008
  9. doi Strain distribution over plaques in human coronary arteries relates to shear stress
    Frank J H Gijsen
    Department of Biomedical Engineering, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 295:H1608-14. 2008
  10. ncbi Usefulness of shear stress pattern in predicting neointima distribution in sirolimus-eluting stents in coronary arteries
    Frank J H Gijsen
    Department of Cardiology, Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands
    Am J Cardiol 92:1325-8. 2003

Collaborators

Detail Information

Publications43

  1. ncbi Shear stress, vascular remodeling and neointimal formation
    Jolanda J Wentzel
    Department of Cardiology, Thoraxcentre EE2322, Erasmus Medical Centre Rotterdam, Erasmus University Rotterdam, P O Box 1738, 3000 DR Rotterdam, Netherlands
    J Biomech 36:681-8. 2003
    ..Attempts to locally increase shear stress by a newly developed flow divider indicate that shear stress reduce in-stent neointimal formation by 50%...
  2. ncbi A new imaging technique to study 3-D plaque and shear stress distribution in human coronary artery bifurcations in vivo
    Frank J H Gijsen
    Department of Biomedical Engineering, Thoraxcenter, Ee2322, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    J Biomech 40:2349-57. 2007
    ..Both are related to blood flow-induced shear stress (SS). We present a new approach to generate 3-D reconstructions of coronary artery bifurcations in vivo and investigate the relationship between SS, wall thickness (WT) and remodeling...
  3. doi Carotid Plaque Morphological Classification Compared With Biomechanical Cap Stress: Implications for a Magnetic Resonance Imaging-Based Assessment
    Frank J H Gijsen
    From the Departments of Biomedical Engineering Thoraxcenter F J H G, H A N, J J W, A F W v d S, Vascular Surgery H J M V, and Radiology A v d L, Erasmus MC, Rotterdam, The Netherlands and Department of Applied Sciences, Delft University of Technology, Delft, The Netherlands A F W v d S
    Stroke 46:2124-8. 2015
    ....
  4. doi 3D reconstruction techniques of human coronary bifurcations for shear stress computations
    Frank J H Gijsen
    Biomedical Engineering, Department of Cardiology, Erasmus MC, PO Box 2040, 3000 CA, Rotterdam, The Netherlands Electronic address
    J Biomech 47:39-43. 2014
    ..Shear stress is generally determined by combing 3D lumen data and computational fluid dynamics (CFD). We investigated two new procedures to generate 3D lumen reconstructions of coronary artery bifurcations for shear stress computations...
  5. doi Shear stress and advanced atherosclerosis in human coronary arteries
    Frank Gijsen
    Department of Biomedical Engineering, Erasmus MC, Rotterdam, The Netherlands
    J Biomech 46:240-7. 2013
    ..The distal plaque regions are exposed to low shear stress, are stiffer and have a stable plaque phenotype. The regions exposed to high shear stress are softer, and are associated with vulnerable plaque features...
  6. pmc Effects of intima stiffness and plaque morphology on peak cap stress
    Ali C Akyildiz
    Department of Biomedical Engineering, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands
    Biomed Eng Online 10:25. 2011
    ..A parametric study was conducted to assess the effect of intima stiffness and plaque morphology on peak cap stress...
  7. doi High shear stress induces a strain increase in human coronary plaques over a 6-month period
    Frank J H Gijsen
    Department of Biomedical Engineering, Thoraxcenter, ErasmusMC, Rotterdam, The Netherlands
    EuroIntervention 7:121-7. 2011
    ..We investigated changes in plaque composition in human coronary arteries over a 6-month period and how these changes are related to shear stress...
  8. pmc Simulation of stent deployment in a realistic human coronary artery
    Frank J H Gijsen
    Department of Biomedical Engineering, Thoraxcentre EE2322, Erasmus Medical Center Rotterdam, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Biomed Eng Online 7:23. 2008
    ..The knowledge of these parameters after stent deployment in a patient derived 3D reconstruction of a diseased coronary artery might give insights in the understanding of the process of restenosis...
  9. doi Strain distribution over plaques in human coronary arteries relates to shear stress
    Frank J H Gijsen
    Department of Biomedical Engineering, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 295:H1608-14. 2008
    ..Higher strain can be found in all other plaque regions, with the highest strain found in regions exposed to the highest shear stresses. This indicates that high shear stress might destabilize plaques, which could lead to plaque rupture...
  10. ncbi Usefulness of shear stress pattern in predicting neointima distribution in sirolimus-eluting stents in coronary arteries
    Frank J H Gijsen
    Department of Cardiology, Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands
    Am J Cardiol 92:1325-8. 2003
    ....
  11. ncbi Geometry guided data averaging enables the interpretation of shear stress related plaque development in human coronary arteries
    Jolanda J Wentzel
    Hemodynamics Laboratory, Department of Cardiology, P O Box 1738, Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands
    J Biomech 38:1551-5. 2005
    ..70+/-0.46 mm/Pa. These data suggest that using a geometry guided way of data averaging may reveal history related effects of SS, which in part explains localization of atherosclerotic plaques...
  12. ncbi Images in Cardiovascular Medicine. True three-dimensional reconstructed images showing lumen enlargement after sirolimus-eluting stent implantation
    Kengo Tanabe
    Division of Cardiology, Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands
    Circulation 106:e179-80. 2002
  13. doi MRI-based quantification of outflow boundary conditions for computational fluid dynamics of stenosed human carotid arteries
    Harald C Groen
    Biomechanics Laboratory, Biomedical Engineering, Ee2322, Erasmus MC, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    J Biomech 43:2332-8. 2010
    ..If patient-specific flow measurements of the carotid bifurcation are unavailable, estimation of the outflow ratio by the presented empirical relation will result in a good approximation of calculated WSS using CFD...
  14. pmc Small coronary calcifications are not detectable by 64-slice contrast enhanced computed tomography
    Alina G van der Giessen
    Biomedical Engineering, Department of Cardiology, Erasmus MC, Biomechanics Laborator, Rotterdam, CA, 3000, The Netherlands
    Int J Cardiovasc Imaging 27:143-52. 2011
    ..Half of the calcifications seen on the IVUS images cannot be detected on contrast enhanced 64-slice MSCT angiography images because of their size. The limited resolution of MSCT is the main reason for missing small calcifications...
  15. doi 3D fusion of intravascular ultrasound and coronary computed tomography for in-vivo wall shear stress analysis: a feasibility study
    Alina G van der Giessen
    Department of Biomedical Engineering, Erasmus MC, Biomechanics Laboratory Ee2322, Rotterdam, The Netherlands
    Int J Cardiovasc Imaging 26:781-96. 2010
    ..This new framework can therefore successfully be applied for shear stress analysis in human coronary arteries...
  16. ncbi Images in cardiovascular medicine. Focal in-stent restenosis near step-up: roles of low and oscillating shear stress?
    Attila Thury
    Department of Cardiology, Thoraxcenter, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands
    Circulation 105:e185-7. 2002
  17. ncbi Plaque and shear stress distribution in human coronary bifurcations: a multislice computed tomography study
    Alina G van der Giessen
    Department of Cardiology and Biomedical Engineering, ErasmusMC, Biomechanics Laboratory Ee2322, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    EuroIntervention 4:654-61. 2009
    ..We assessed the plaque distribution and morphology near bifurcations non-invasively with 64-slice computed tomography in relation to the WSS distribution...
  18. doi In vivo validation of CAAS QCA-3D coronary reconstruction using fusion of angiography and intravascular ultrasound (ANGUS)
    Johan C H Schuurbiers
    Biomedical Engineering, ErasmusMC, Rotterdam, The Netherlands
    Catheter Cardiovasc Interv 73:620-6. 2009
    ....
  19. doi The influence of boundary conditions on wall shear stress distribution in patients specific coronary trees
    Alina G van der Giessen
    Department of Biomedical Engineering, Erasmus Erasmus MC, Biomechanics Laboratory Ee2322, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    J Biomech 44:1089-95. 2011
    ..Especially near side branches, the regions where atherosclerotic plaques preferentially develop, the differences are significant and application of Murray's law underestimates the size of the low WSS region...
  20. doi Local anisotropic mechanical properties of human carotid atherosclerotic plaques - characterisation by micro-indentation and inverse finite element analysis
    Chen Ket Chai
    Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, GEM Z 4 11, 5600 MB Eindhoven, The Netherlands Electronic address
    J Mech Behav Biomed Mater 43:59-68. 2015
    ..There were no significant differences between the different indentation locations for the fibre stiffness (total median 80.6kPa, 25th-75th percentile 17.7-157.0kPa), and fibre dispersion. ..
  21. doi Impact of plaque type and side branch geometry on side branch compromise after provisional stent implantation. A simulation study
    Francesco Iannaccone
    Department of Cardiology, Biomedical Engineering, Erasmus MC, Rotterdam, The Netherlands
    EuroIntervention . 2016
    ..Mechanisms of lumen compromise after provisional side-branch (SB) stenting are poorly understood. In this study we investigated the impact of bifurcation angle, plaque composition, and procedural strategy on SB compromise...
  22. doi The effects of plaque morphology and material properties on peak cap stress in human coronary arteries
    Ali C Akyildiz
    a Department of Biomedical Engineering, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands
    Comput Methods Biomech Biomed Engin 19:771-9. 2016
    ..66). The results of this study imply that not only accurate assessment of plaque geometry, but also of intima properties is essential for cap stress analyses in atherosclerotic plaques in human coronary arteries...
  23. doi In vivo assessment of the relationship between shear stress and necrotic core in early and advanced coronary artery disease
    Jolanda J Wentzel
    Biomedical Engineering, ErasmusMC, Rotterdam, The Netherlands
    EuroIntervention 9:989-95; discussion 995. 2013
    ..We investigated in human coronary arteries in vivo the frequency with which the necrotic core and necrotic core in contact with the lumen are located at either low or high WSS regions in early and advanced plaques...
  24. pmc A computer-simulation study on the effects of MRI voxel dimensions on carotid plaque lipid-core and fibrous cap segmentation and stress modeling
    Harm A Nieuwstadt
    Department of Biomedical Engineering, Erasmus MC, Rotterdam, The Netherlands
    PLoS ONE 10:e0123031. 2015
    ....
  25. ncbi Plaque rupture in the carotid artery is localized at the high shear stress region: a case report
    Harald C Groen
    Biomedical Engineering, Biomechanics Laboratory, Erasmus MC, CA Rotterdam, The Netherlands
    Stroke 38:2379-81. 2007
    ..Our data suggest that high WSS influences plaque vulnerability and therefore may become a potential parameter for predicting future events...
  26. doi Functional and anatomical measures for outflow boundary conditions in atherosclerotic coronary bifurcations
    Jelle T C Schrauwen
    Department of Biomedical Engineering, Thorax Center, Erasmus Medical Center, Gravendijkwal 230, Faculty Building, Ee 2302, 3000 CA Rotterdam, The Netherlands Electronic address
    J Biomech 49:2127-34. 2016
    ..FFR and normalized WSS were unaffected by the variations in outflow ratios. In order to compute absolute WSS a functional measure to set the outflow ratio might be of added value in this type of vessels. ..
  27. pmc A Framework for Local Mechanical Characterization of Atherosclerotic Plaques: Combination of Ultrasound Displacement Imaging and Inverse Finite Element Analysis
    Ali C Akyildiz
    Biomechanics Lab, Department of Biomedical Engineering, Thoraxcenter, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Ann Biomed Eng 44:968-79. 2016
    ....
  28. pmc Peak cap stress calculations in coronary atherosclerotic plaques with an incomplete necrotic core geometry
    Annette M Kok
    Department of Cardiology, Biomedical Engineering, Erasmus MC, Rotterdam, The Netherlands
    Biomed Eng Online 15:48. 2016
    ..The goal of this study was to investigate whether peak cap stresses can be approximated by reconstructing the backside of the NC...
  29. doi Three-dimensional registration of histology of human atherosclerotic carotid plaques to in-vivo imaging
    Harald C Groen
    Biomedical Engineering, ErasmusMC, 3000 CA Rotterdam, The Netherlands
    J Biomech 43:2087-92. 2010
    ..This new 3D-reconstruction technique of atherosclerotic plaque tissue opens new avenues in the field of biomechanics as well as in the field of image processing, where it can be used for validation purposes of segmentation algorithms...
  30. doi Numerical simulations of carotid MRI quantify the accuracy in measuring atherosclerotic plaque components in vivo
    Harm A Nieuwstadt
    Department of Biomedical Engineering, Erasmus Medical Center, Rotterdam, The Netherlands
    Magn Reson Med 72:188-201. 2014
    ..However, the accuracy in segmentation and quantification of components such as the thin fibrous cap (FC) and lipid-rich necrotic core (LRNC) remains unknown due to the lack of a submillimeter scale ground truth...
  31. ncbi Influence of catheter design on lumen wall temperature distribution in intracoronary thermography
    Anna G ten Have
    Department of Biomedical Engineering, Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands
    J Biomech 40:281-8. 2007
    ..Catheter design can contribute to enhanced temperature readings and thus can enable more optimal vulnerable plaque detection...
  32. doi Positive remodeling at 3 year follow up is associated with plaque-free coronary wall segment at baseline: a serial IVUS study
    Jolanda J Wentzel
    Department of Biomedical Engineering, ErasmusMC, Rotterdam, The Netherlands The Interuniversity Cardiology Institute the Netherlands, Utrecht, The Netherlands Electronic address
    Atherosclerosis 236:82-90. 2014
    ..As endothelium at the plaque site is assumed to be dysfunctional, we tested the hypothesis that plaque free wall (PFW) determines vascular remodeling during atherosclerotic plaque build-up...
  33. doi The effects of stenting on shear stress: relevance to endothelial injury and repair
    Kim Van der Heiden
    Biomedical Engineering, Department Cardiology, ErasmusMC, Rotterdam, The Netherlands
    Cardiovasc Res 99:269-75. 2013
    ....
  34. doi Detection and quantification of coronary atherosclerotic plaque by 64-slice multidetector CT: a systematic head-to-head comparison with intravascular ultrasound
    Stella Lida Papadopoulou
    Department of Cardiology, Erasmus University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Atherosclerosis 219:163-70. 2011
    ..We evaluated the ability of 64-slice multidetector computed tomography (MDCT)-derived plaque parameters to detect and quantify coronary atherosclerosis, using intravascular ultrasound (IVUS) as the reference standard...
  35. pmc Coronary fractional flow reserve measurements of a stenosed side branch: a computational study investigating the influence of the bifurcation angle
    Claudio Chiastra
    Department of Cardiology, Biomedical Engineering, Erasmus MC, Rotterdam, The Netherlands
    Biomed Eng Online 15:91. 2016
    ..To investigate the influence of the bifurcation angle on the intracoronary hemodynamics of side branch (SB) lesions computational fluid dynamics simulations were performed...
  36. doi The impact of scaled boundary conditions on wall shear stress computations in atherosclerotic human coronary bifurcations
    Jelle T C Schrauwen
    Department of Biomedical Engineering, Thorax Center, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 310:H1304-12. 2016
    ..Caution should be taken when absolute WSS is assessed from computations using scaled boundary conditions. ..
  37. pmc Influence of the Accuracy of Angiography-Based Reconstructions on Velocity and Wall Shear Stress Computations in Coronary Bifurcations: A Phantom Study
    Jelle T C Schrauwen
    Department of Biomedical Engineering, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS ONE 10:e0145114. 2015
    ..It is essential to evaluate how reconstruction errors influence WSS computations in mildly-diseased coronary bifurcations. In mildly-diseased lesions WSS could potentially provide more insight in plaque progression...
  38. doi Fast and accurate pressure-drop prediction in straightened atherosclerotic coronary arteries
    Jelle T C Schrauwen
    Department of Biomedical Engineering, Erasmus Medical Center, s Gravendijkwal 230, Faculty Building, Ee 2302, 3000 CA, Rotterdam, The Netherlands
    Ann Biomed Eng 43:59-67. 2015
    ..9 ± 4.9% difference at Re = 150. We showed that this method can quickly and accurately predict pressure-drop on the basis of geometry and flow in straightened coronary arteries that are mildly diseased...
  39. doi Endothelial shear stress in the evolution of coronary atherosclerotic plaque and vascular remodelling: current understanding and remaining questions
    Jolanda J Wentzel
    Biomedical Engineering, Department Cardiology, ErasmusMC, Rotterdam, The Netherlands
    Cardiovasc Res 96:234-43. 2012
    ....
  40. doi Wall shear stress calculations based on 3D cine phase contrast MRI and computational fluid dynamics: a comparison study in healthy carotid arteries
    Merih Cibis
    Department of Biomedical Engineering, Erasmus MC Rotterdam, The Netherlands
    NMR Biomed 27:826-34. 2014
    ..PC-MRI-based WSS has potential to be used in the clinic to indicate regions of low and high WSS and the direction of WSS, especially in regions of high WSS...
  41. doi Mechanical properties of human atherosclerotic intima tissue
    Ali C Akyildiz
    Department of Biomedical Engineering, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands
    J Biomech 47:773-83. 2014
    ..With this understanding, biomechanical plaque modeling may eventually provide essential support for clinical plaque risk stratification. ..
  42. doi Local axial compressive mechanical properties of human carotid atherosclerotic plaques-characterisation by indentation test and inverse finite element analysis
    Chen Ket Chai
    Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    J Biomech 46:1759-66. 2013
    ....
  43. doi Animal models for plaque rupture: a biomechanical assessment
    Kim Van der Heiden
    K van der Heiden, P O Box 2040, 3000 CA Rotterdam, The Netherlands, Tel 31 10 703 81 66, E mail
    Thromb Haemost 115:501-8. 2016
    ..In this review we describe the role of the biomechanical environment in plaque rupture and assess this environment in animal models that present with plaque rupture. ..