Abbas Dehghan

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. doi Comparison of prognosis in unrecognized versus recognized myocardial infarction in men versus women >55 years of age (from the Rotterdam Study)
    Abbas Dehghan
    Department of Epidemiology, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, The Netherlands Electronic address
    Am J Cardiol 113:1-6. 2014
  2. pmc Lack of association of two common polymorphisms on 9p21 with risk of coronary heart disease and myocardial infarction; results from a prospective cohort study
    Abbas Dehghan
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    BMC Med 6:30. 2008
  3. doi Risk scores of common genetic variants for lipid levels influence atherosclerosis and incident coronary heart disease
    Aaron Isaacs
    Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 33:2233-9. 2013
  4. pmc Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study
    Mandy van Hoek
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    Diabetes 57:3122-8. 2008
  5. doi SIRT1 genetic variation and mortality in type 2 diabetes: interaction with smoking and dietary niacin
    M Carola Zillikens
    Department of Internal Medicine, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    Free Radic Biol Med 46:836-41. 2009
  6. ncbi ADAMTS13 activity as a novel risk factor for incident type 2 diabetes mellitus: a population-based cohort study
    Paul S de Vries
    Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Diabetologia . 2016
  7. pmc Serum uric acid and chronic kidney disease: the role of hypertension
    Sanaz Sedaghat
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS ONE 8:e76827. 2013
  8. pmc Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study
    Abbas Dehghan
    Department of Epidemiology, Erasmus Medical Centre, Rotterdam, Netherlands
    Lancet 372:1953-61. 2008
  9. ncbi Risk of type 2 diabetes attributable to C-reactive protein and other risk factors
    Abbas Dehghan
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Diabetes Care 30:2695-9. 2007
  10. doi von Willebrand Factor, ADAMTS13 Activity, and Decline in Kidney Function: A Population-Based Cohort Study
    Sanaz Sedaghat
    Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Am J Kidney Dis 68:726-732. 2016

Detail Information

Publications62

  1. doi Comparison of prognosis in unrecognized versus recognized myocardial infarction in men versus women >55 years of age (from the Rotterdam Study)
    Abbas Dehghan
    Department of Epidemiology, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, The Netherlands Electronic address
    Am J Cardiol 113:1-6. 2014
    ..In men, the prognosis is as unfavorable as that of patients with recognized MIs. ..
  2. pmc Lack of association of two common polymorphisms on 9p21 with risk of coronary heart disease and myocardial infarction; results from a prospective cohort study
    Abbas Dehghan
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    BMC Med 6:30. 2008
    ..We examined the SNPs in relation to the risk of CHD and MI in a large population based study of elderly population...
  3. doi Risk scores of common genetic variants for lipid levels influence atherosclerosis and incident coronary heart disease
    Aaron Isaacs
    Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 33:2233-9. 2013
    ..We tested the hypothesis that the cumulative effects of common genetic variants for lipids are collectively associated with subclinical atherosclerosis and incident coronary heart disease...
  4. pmc Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study
    Mandy van Hoek
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    Diabetes 57:3122-8. 2008
    ..Genome-wide association (GWA) studies identified multiple new genetic variants that associate with type 2 diabetes. The predictive value of genetic testing for prediction of type 2 diabetes in the general population is unclear...
  5. doi SIRT1 genetic variation and mortality in type 2 diabetes: interaction with smoking and dietary niacin
    M Carola Zillikens
    Department of Internal Medicine, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    Free Radic Biol Med 46:836-41. 2009
    ..Correction of niacin deficiency and SIRT1 modulators may prolong the life span of patients with diabetes...
  6. ncbi ADAMTS13 activity as a novel risk factor for incident type 2 diabetes mellitus: a population-based cohort study
    Paul S de Vries
    Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Diabetologia . 2016
    ..VWF has been associated with an increased risk of incident type 2 diabetes mellitus. Here, we determine whether ADAMTS13 activity and VWF antigen are associated with incident diabetes...
  7. pmc Serum uric acid and chronic kidney disease: the role of hypertension
    Sanaz Sedaghat
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS ONE 8:e76827. 2013
    ..In this population-based study we investigated the association between serum uric acid and decline in renal function and tested whether hypertension moderates this association...
  8. pmc Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study
    Abbas Dehghan
    Department of Epidemiology, Erasmus Medical Centre, Rotterdam, Netherlands
    Lancet 372:1953-61. 2008
    ..Hyperuricaemia, a highly heritable trait, is a key risk factor for gout. We aimed to identify novel genes associated with serum uric acid concentration and gout...
  9. ncbi Risk of type 2 diabetes attributable to C-reactive protein and other risk factors
    Abbas Dehghan
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Diabetes Care 30:2695-9. 2007
    ..To calculate the population-attributable risk (PAR) of C-reactive protein (CRP) and other risk factors for type 2 diabetes...
  10. doi von Willebrand Factor, ADAMTS13 Activity, and Decline in Kidney Function: A Population-Based Cohort Study
    Sanaz Sedaghat
    Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Am J Kidney Dis 68:726-732. 2016
    ..Altered levels of von Willebrand factor (vWF) and ADAMTS13 can promote thrombosis and disturb blood flow in kidney microcirculations. We investigated the association of serum vWF:ADAMTS13 ratio in relation to decline in kidney function...
  11. doi The Influence of Serum Uric Acid on Bone Mineral Density, Hip Geometry, and Fracture Risk: The Rotterdam Study
    Taulant Muka
    Departments of Epidemiology T M, E A L d J, J C K d J, A G U, A H, A D, O H F, F R and Internal Medicine E A L d J, A G U, M C Z, F R, Erasmus Medical Center, Rotterdam CA 3000, The Netherlands Netherlands Consortium for Healthy Ageing A G U, A H, A D, M C Z, O H F, F R, Netherlands Genomics Initiative, The Hague 2593 CE, The Netherlands and Leiden University College J C K d J, The Hague 3595 DG, The Netherlands
    J Clin Endocrinol Metab 101:1113-22. 2016
    ..The role of uric acid (UA) in skeletal metabolism remains to be unraveled...
  12. pmc Tobacco smoking is associated with DNA methylation of diabetes susceptibility genes
    Symen Ligthart
    Department of Epidemiology, Erasmus University Medical Center, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Diabetologia 59:998-1006. 2016
    ..Tobacco smoking, a risk factor for diabetes, is an established modifier of DNA methylation. We hypothesised that tobacco smoking modifies DNA methylation of genes previously identified for diabetes...
  13. doi Thyroid Function Characteristics and Determinants: The Rotterdam Study
    Layal Chaker
    1 Rotterdam Thyroid Center, Erasmus University Medical Center, Rotterdam, The Netherlands
    Thyroid 26:1195-204. 2016
    ....
  14. doi Lifetime risk of developing impaired glucose metabolism and eventual progression from prediabetes to type 2 diabetes: a prospective cohort study
    Symen Ligthart
    Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands
    Lancet Diabetes Endocrinol 4:44-51. 2016
    ..We aimed to calculate the lifetime risk of the full range of glucose impairments, from normoglycaemia to prediabetes, type 2 diabetes, and eventual insulin use...
  15. doi Kidney function and microstructural integrity of brain white matter
    Sanaz Sedaghat
    From the Departments of Epidemiology S S, L G M C, M D G, A H, O H F, M W V, A D, M A I, Radiology L G M C, M D G, A v d L, M W V, M A I, Medical informatics M d G, Internal Medicine E J H, and Neurology M A I, Erasmus University Medical Center, Rotterdam, The Netherlands
    Neurology 85:154-61. 2015
    ..To investigate the association of kidney function with white matter microstructural integrity...
  16. ncbi High serum uric acid as a novel risk factor for type 2 diabetes
    Abbas Dehghan
    Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, P O Box 2040, 3000 CA Rotterdam, Netherlands
    Diabetes Care 31:361-2. 2008
    ..To investigate the association between serum uric acid level and risk of type 2 diabetes...
  17. pmc Genome-wide identification of microRNA-related variants associated with risk of Alzheimer's disease
    Mohsen Ghanbari
    Department of Epidemiology, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands
    Sci Rep 6:28387. 2016
    ..Collectively, this study shows that miRNA-related variants are associated with AD and suggests miRNA-dependent regulation of several AD genes. ..
  18. pmc The clinical value of metabolic syndrome and risks of cardiometabolic events and mortality in the elderly: the Rotterdam study
    Thijs T W van Herpt
    Department of Epidemiology, Erasmus Medical Center Rotterdam, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Cardiovasc Diabetol 15:69. 2016
    ....
  19. doi Metabolic syndrome is related to polyneuropathy and impaired peripheral nerve function: a prospective population-based cohort study
    Rens Hanewinckel
    Department of Epidemiology, Erasmus University Medical Centre Rotterdam, Rotterdam, The Netherlands Department of Neurology, Erasmus University Medical Centre Rotterdam, Rotterdam, The Netherlands
    J Neurol Neurosurg Psychiatry . 2016
    ..Diabetes mellitus is a known risk factor for polyneuropathy, but the role of pre-diabetes and metabolic syndrome remains unclear. We aimed to investigate the role of these factors in a community-dwelling middle-aged and elderly population...
  20. doi Serum Levels of Apolipoproteins and Incident Type 2 Diabetes: A Prospective Cohort Study
    Adela Brahimaj
    Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Diabetes Care . 2016
    ..We aimed to investigate the role of serum levels of various apolipoproteins on the risk for type 2 diabetes (T2D)...
  21. pmc Gait patterns associated with thyroid function: The Rotterdam Study
    Arjola Bano
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    Sci Rep 6:38912. 2016
    ..In euthyroid participants, higher thyroid function was associated with worse gait patterns. In conclusion, both low and high thyroid function are associated with alterations in Global gait, Tandem, Base of support and velocity...
  22. pmc Thyroid function and risk of type 2 diabetes: a population-based prospective cohort study
    Layal Chaker
    Rotterdam Thyroid Center, Erasmus University Medical Center, Rotterdam, The Netherlands
    BMC Med 14:150. 2016
    ..We aimed to investigate the association of thyroid function with incident diabetes and progression from prediabetes to diabetes in a population-based prospective cohort study...
  23. pmc Vitamin D and C-Reactive Protein: A Mendelian Randomization Study
    Marte C Liefaard
    Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands Netherlands Institute for Health Sciences, Rotterdam, The Netherlands
    PLoS ONE 10:e0131740. 2015
    ..001; p = 0.998). In conclusion, higher levels of Vitamin D are associated with lower levels of C-reactive protein. In this study we did not find evidence for this to be the result of a causal relationship. ..
  24. doi Genetic Variants in MicroRNAs and Their Binding Sites Are Associated with the Risk of Parkinson Disease
    Mohsen Ghanbari
    Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3000, CA, The Netherlands
    Hum Mutat 37:292-300. 2016
    ..We provide evidence supporting the potential impact of the identified miRNA-binding site variants on miRNA-mediated regulation of their host genes. ..
  25. pmc The Association between Metabolic Syndrome, Bone Mineral Density, Hip Bone Geometry and Fracture Risk: The Rotterdam Study
    Taulant Muka
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS ONE 10:e0129116. 2015
    ..In conclusion, women with MS had higher FN-BMD independent of BMI. The glucose component of MS was associated with high FN-BMD in both genders, highlighting the need to preserve glycemic control to prevent skeletal complications. ..
  26. doi Incremental predictive value of 152 single nucleotide polymorphisms in the 10-year risk prediction of incident coronary heart disease: the Rotterdam Study
    Paul S de Vries
    Department of Epidemiology, and Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Int J Epidemiol 44:682-8. 2015
    ..To examine the incremental predictive value of genetic risk scores of coronary heart disease (CHD) in the 10-year risk prediction of incident CHD...
  27. pmc Pleiotropy among common genetic loci identified for cardiometabolic disorders and C-reactive protein
    Symen Ligthart
    Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
    PLoS ONE 10:e0118859. 2015
    ..In addition to reverse causation, our data suggests that pleiotropic genetic variants partially underlie the association between CRP and cardiometabolic phenotypes. ..
  28. doi Association of renal function with vascular stiffness in older adults: the Rotterdam study
    Sanaz Sedaghat
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Age Ageing 43:827-33. 2014
    ..A potential mechanism linking cardiovascular disease to chronic kidney disease might be the change in arterial elasticity. We aim to determine the association between renal function and arterial stiffness in older subjects...
  29. pmc Thyroid function and age-related macular degeneration: a prospective population-based cohort study--the Rotterdam Study
    Layal Chaker
    Rotterdam Thyroid Center, Erasmus University Medical Center, Rotterdam, The Netherlands
    BMC Med 13:94. 2015
    ..The association between thyroid function and age-related macular degeneration (AMD) has not been investigated in the general population...
  30. pmc Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels
    Abbas Dehghan
    Erasmus Medical Center, Dr Molewaterplein 50, Rotterdam, Netherlands
    Circulation 123:731-8. 2011
    ..C-reactive protein (CRP) is a heritable marker of chronic inflammation that is strongly associated with cardiovascular disease. We sought to identify genetic variants that are associated with CRP levels...
  31. doi Thyroid Function and the Risk of Nonalcoholic Fatty Liver Disease: The Rotterdam Study
    Arjola Bano
    Department of Internal Medicine A B, L C, R P P, Erasmus University Medical Center, 3015 GE, Rotterdam, The Netherlands Rotterdam Thyroid Center A B, L C, R P P, Erasmus University Medical Center, 3015 GE, Rotterdam, The Netherlands Department of Epidemiology A B, L C, E P C P, A H, A D, O H F, S d M, R P P, Erasmus University Medical Center, 3015 GE, Rotterdam, The Netherlands Department of Gastroenterology and Hepatology E P C P, H L A J, S d M, Erasmus University Medical Center, 3015 GE, Rotterdam, The Netherlands and Toronto Centre for Liver Disease H L A J, Toronto Western and General Hospital, University Health Network, Toronto, Ontario, M5G 2C4 Canada
    J Clin Endocrinol Metab 101:3204-11. 2016
    ..Although thyroid function is associated with several risk factors of nonalcoholic fatty liver disease (NAFLD), its role in NAFLD development remains unclear...
  32. doi The role of epigenetic modifications in cardiovascular disease: A systematic review
    Taulant Muka
    Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands Electronic address
    Int J Cardiol 212:174-83. 2016
    ....
  33. pmc Heritabilities, proportions of heritabilities explained by GWAS findings, and implications of cross-phenotype effects on PR interval
    Claudia Tamar Silva
    Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Hum Genet 134:1211-9. 2015
    ..In addition, larger GWAS for PR are likely to detect loci already identified, particularly those observed for QRS and 12-lead sum...
  34. doi Association of uric acid genetic risk score with blood pressure: the Rotterdam study
    Sanaz Sedaghat
    Departments of Epidemiology S S, R P, A G U, A H, B H Ch S, O H F, A D, M A I, Internal Medicine A G U, Radiology M A I, and Neurology M A I, Erasmus University Medical Center, Rotterdam, The Netherlands
    Hypertension 64:1061-6. 2014
    ..Our study suggests that genome wide association study's findings can be associated with an intermediate factor or have a pleiotropic role and, therefore, should be applied for Mendelian Randomization with caution. ..
  35. ncbi Genetic variation, C-reactive protein levels, and incidence of diabetes
    Abbas Dehghan
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    Diabetes 56:872-8. 2007
    ..45, 95% CI 1.08-1.96). These findings support the hypothesis that serum CRP enhances the development of diabetes...
  36. pmc Obesity and Life Expectancy with and without Diabetes in Adults Aged 55 Years and Older in the Netherlands: A Prospective Cohort Study
    Klodian Dhana
    Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    PLoS Med 13:e1002086. 2016
    ..We aimed to determine the association of overweight and obesity with the number of years lived with and without diabetes in a middle-aged and elderly population...
  37. pmc Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation
    Symen Ligthart
    Department of Epidemiology, Erasmus University Medical Center, PO Box 2040, 3000CA, Rotterdam, The Netherlands
    BMC Genomics 17:443. 2016
    ..We aimed to identify genetic pleiotropy among CRP and lipids in order to better understand the shared biology of chronic inflammation and lipid metabolism...
  38. ncbi Serum dehydroepiandrosterone levels are associated with lower risk of type 2 diabetes: the Rotterdam Study
    Adela Brahimaj
    Department of Epidemiology, Erasmus University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Diabetologia 60:98-106. 2017
    ..We aimed to assess the associations between serum levels of DHEA and its main derivatives DHEA sulphate (DHEAS) and androstenedione, as well as the ratio of DHEAS to DHEA, and risk of type 2 diabetes...
  39. doi Gait characteristics in older adults with diabetes and impaired fasting glucose: The Rotterdam Study
    Ana Maksimovic
    Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Diabetes Complications 30:61-6. 2016
    ..To investigate the association of diabetes mellitus and impaired fasting glucose with gait in the general middle-aged and elderly population...
  40. doi EN-RAGE: a novel inflammatory marker for incident coronary heart disease
    Symen Ligthart
    From the Department of Epidemiology S L, S S, M A I, A H, O H F, A D, Department of Neurology M A I, and Department of Radiology M A I, Erasmus University Medical Center, Rotterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 34:2695-9. 2014
    ..Inflammation plays a key role in atherosclerosis. We hypothesized that novel inflammatory markers may predict the risk of coronary heart disease (CHD)...
  41. doi The association of common polymorphisms in miR-196a2 with waist to hip ratio and miR-1908 with serum lipid and glucose
    Mohsen Ghanbari
    Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
    Obesity (Silver Spring) 23:495-503. 2015
    ..Given the crucial role of miRNAs in gene expression, genetic variation within miRNA genes is expected to affect miRNA function and substantially contribute to disease risk...
  42. pmc Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease
    Joyce B J van Meurs
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    Am J Clin Nutr 98:668-76. 2013
    ....
  43. doi The relation of uric acid to brain atrophy and cognition: the Rotterdam Scan Study
    Benjamin F J Verhaaren
    Department of Epidemiology, Erasmus MC University Medical Center, NL 3000 CA Rotterdam, The Netherlands
    Neuroepidemiology 41:29-34. 2013
    ..However, it is unknown whether uric acid also relates to global brain changes such as brain atrophy. We therefore studied the relation of uric acid to brain atrophy and whether this is accompanied by worse cognitive function...
  44. pmc Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts
    Abbas Dehghan
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Circ Cardiovasc Genet 2:125-33. 2009
    ..Fibrinogen is both central to blood coagulation and an acute-phase reactant. We aimed to identify common variants influencing circulation fibrinogen levels...
  45. pmc Comparison of HapMap and 1000 Genomes Reference Panels in a Large-Scale Genome-Wide Association Study
    Paul S de Vries
    Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands
    PLoS ONE 12:e0167742. 2017
    ..More generally, our results provide insights that are applicable to the implementation of other dense reference panels that are under development...
  46. pmc Genome-Wide Association Study for Incident Myocardial Infarction and Coronary Heart Disease in Prospective Cohort Studies: The CHARGE Consortium
    Abbas Dehghan
    Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
    PLoS ONE 11:e0144997. 2016
    ..Data are limited on genome-wide association studies (GWAS) for incident coronary heart disease (CHD). Moreover, it is not known whether genetic variants identified to date also associate with risk of CHD in a prospective setting...
  47. doi LDL cholesterol still a problem in old age? A Mendelian randomization study
    Iris Postmus
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands, Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands, Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands, Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands, Leyden Academy of Vitality and Ageing, Leiden, The Netherlands, Faculty of Health and Medical Sciences, Department of Public Health, University of Copenhagen, Copenhagen, Denmark, Durrer Center for Cardiogenetic Research, Amsterdam, The Netherlands and Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands, Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands, Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands, Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands, Leyden Academy of Vitality and Ageing, Leiden, The Netherlands, Faculty of Health and Medical Sciences, Department of Public Health, University of Copenhagen, Copenhagen, Denmark, Laboratory of Tropical and Subtropical Agriculture and Ethnobotany
    Int J Epidemiol 44:604-12. 2015
    ..In the current study, we used an LDL genetic risk score (GRS) to overcome this problem...
  48. doi Subclinical thyroid dysfunction and the risk of stroke: a systematic review and meta-analysis
    Layal Chaker
    Department of Internal Medicine, Thyroid Center, Erasmus University Medical Center, Room Ee502, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Epidemiol 29:791-800. 2014
    ..Also, there were insufficient events to exclude clinically significant risk from subclinical hyperthyroidism, and more data are required for subgroup analyses...
  49. pmc Low-risk susceptibility alleles in 40 human breast cancer cell lines
    Muhammad Riaz
    Department of Medical Oncology, Josephine Nefkens Institute, Erasmus University Medical Center, Rotterdam, The Netherlands
    BMC Cancer 9:236. 2009
    ..The mechanism by which the low-risk SNPs confer breast cancer risks is currently unclear. The breast cancer association consortium BCAC has hypothesized that the low-risk SNPs modulate expression levels of nearby located genes...
  50. doi The role of DNA methylation in dyslipidaemia: A systematic review
    Kim V E Braun
    Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands Electronic address
    Prog Lipid Res 64:178-191. 2016
    ....
  51. pmc Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels
    Elisabeth M van Leeuwen
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Med Genet 53:441-9. 2016
    ..In this study we aimed to identify more new rare and low-frequency functional variants associated with circulating lipid levels...
  52. pmc Genome-wide association studies identify genetic loci for low von Willebrand factor levels
    Janine van Loon
    Department of Hematology, Erasmus University Medical Centre, Rotterdam, The Netherlands
    Eur J Hum Genet 24:1035-40. 2016
    ..These findings point to novel mechanisms for the occurrence of low VWF levels. ..
  53. pmc Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis
    Frank J A van Rooij
    Department of Epidemiology, Erasmus MC, 3000 CA Rotterdam, The Netherlands
    Am J Hum Genet . 2016
    ..Our findings show the utility of trans-ethnic GWASs for discovery and characterization of genetic loci influencing hematologic traits...
  54. pmc Adiposity as a cause of cardiovascular disease: a Mendelian randomization study
    Sara Hägg
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden, Molecular Epidemiology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Estonian Genome Center, University of Tartu, Tartu, Estonia, Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands, EMGO Institute for Health and Care Research, Amsterdam, The Netherlands, Institute of Mathematical Statistics, University of Tartu, Tartu, Estonia, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, Leiden, The Netherlands, Department of Genetic Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland, National Institute for Health and Welfare, Helsinki, Finland, Department of Neurology, and Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands, Inspectorate for Health Care, The Hague, The Netherlands, Queensland Brain Institute, University of Queensland, Department of Biochemistry
    Int J Epidemiol 44:578-86. 2015
    ..Adiposity, as indicated by body mass index (BMI), has been associated with risk of cardiovascular diseases in epidemiological studies. We aimed to investigate if these associations are causal, using Mendelian randomization (MR) methods...
  55. doi Blood pressure parameters and carotid intraplaque hemorrhage as measured by magnetic resonance imaging: The Rotterdam Study
    Mariana Selwaness
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Hypertension 61:76-81. 2013
    ..The association between pulsatile flow and IPH may provide novel insights in the development of the vulnerable plaque...
  56. pmc High bone mineral density and fracture risk in type 2 diabetes as skeletal complications of inadequate glucose control: the Rotterdam Study
    Ling Oei
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Diabetes Care 36:1619-28. 2013
    ..Individuals with type 2 diabetes have increased fracture risk despite higher bone mineral density (BMD). Our aim was to examine the influence of glucose control on skeletal complications...
  57. pmc Renal function is related to severity of coronary artery calcification in elderly persons: the Rotterdam study
    Abdelilah El Barzouhi
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS ONE 6:e16738. 2011
    ..Since renal function diminishes with aging we examined the association between GFR and CAC in the Rotterdam Study, a population-based study of elderly individuals...
  58. pmc DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases
    Symen Ligthart
    Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Genome Biol 17:255. 2016
    ..Identifying genetic loci where DNA methylation is associated with chronic low-grade inflammation may reveal novel pathways or therapeutic targets for inflammation...
  59. pmc LOng-term follow-up after liVE kidney donation (LOVE) study: a longitudinal comparison study protocol
    Shiromani Janki
    Department of Surgery, division of HPB and Transplant Surgery, Erasmus University Medical Center, s Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands
    BMC Nephrol 17:14. 2016
    ..The benefits of live donor kidney transplantation must be balanced against the potential harm to the donor. Well-designed prospective studies are needed to study the long-term consequences of kidney donation...
  60. pmc Identifying genetic risk variants for coronary heart disease in familial hypercholesterolemia: an extreme genetics approach
    Jorie Versmissen
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    Eur J Hum Genet 23:381-7. 2015
    ..Most likely, this method is not as effective in leveraging effect size as anticipated, and may, therefore, not lead to significant gains in statistical power...
  61. doi A genetic variant in the seed region of miR-4513 shows pleiotropic effects on lipid and glucose homeostasis, blood pressure, and coronary artery disease
    Mohsen Ghanbari
    Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
    Hum Mutat 35:1524-31. 2014
    ..Our findings indicate a pleiotropic effect of miR-4513 on cardiometabolic phenotypes and may improve our understanding of the pathophysiology of cardiometabolic diseases. ..
  62. pmc Variance heterogeneity analysis for detection of potentially interacting genetic loci: method and its limitations
    Maksim V Struchalin
    Department of Epidemiology, Erasmus MC, Rotterdam, 3000 CA, The Netherlands
    BMC Genet 11:92. 2010
    ..In this work, we evaluated statistical properties of variance heterogeneity analysis in respect to the detection of potentially interacting SNPs in a case when an interaction variable is unknown...