J C de Jongste

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. pmc Ceramides: a potential therapeutic target in pulmonary emphysema
    Jeroen Tibboel
    Physiology and Experimental Medicine Program, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Respir Res 14:96. 2013
  2. pmc Early life microbial exposure and fractional exhaled nitric oxide in school-age children: a prospective birth cohort study
    Lidia Casas
    Centre for Research in Environmental Epidemiology CREAL, Barcelona, Spain
    Environ Health 12:103. 2013
  3. pmc Urinary eosinophil protein X in childhood asthma: relation with changes in disease control and eosinophilic airway inflammation
    Marianne Nuijsink
    Department of Pediatric Respiratory Medicine, Juliana Children s Hospital, Haga Teaching Hospital, P O Box 60605, 2506 LP, The Hague, The Netherlands
    Mediators Inflamm 2013:532619. 2013
  4. pmc Exhaled nitric oxide measurements in the first 2 years of life: methodological issues, clinical and epidemiological applications
    Carmelo Gabriele
    Department of Pediatrics, Salesi Children s Hospital, Azienda Ospedaliero Universitaria Ospedali Riuniti, Ancona, Italy
    Ital J Pediatr 35:21. 2009
  5. pmc Air pollution, fetal and infant tobacco smoke exposure, and wheezing in preschool children: a population-based prospective birth cohort
    Agnes M M Sonnenschein-van der Voort
    Department of Pediatrics, Division of Respiratory Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Environ Health 11:91. 2012
  6. pmc Predicting asthma in preschool children with asthma symptoms: study rationale and design
    Esther Hafkamp-de Groen
    The Generation R Study Group, Erasmus MC, Rotterdam, The Netherlands
    BMC Pulm Med 12:65. 2012
  7. pmc Early respiratory morbidity in a multicultural birth cohort: the Generation R Study
    Carmelo Gabriele
    The Generation R Study Group, Erasmus University Medical Centre, Sophia Children s Hospital, Rotterdam, The Netherlands
    Eur J Epidemiol 27:453-62. 2012
  8. doi request reprint Exhaled nitric oxide and the risk of wheezing in infancy: the Generation R Study
    C Gabriele
    Dept of Paediatrics Respiratory Medicine, Erasmus University Medical Center, Rotterdam 3000 CB, The Netherlands
    Eur Respir J 39:567-72. 2012
  9. pmc Quantification of the energy gap in young overweight children. The PIAMA birth cohort study
    Saskia W van den Berg
    National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    BMC Public Health 11:326. 2011
  10. pmc Comorbidities of obesity in school children: a cross-sectional study in the PIAMA birth cohort
    Alet H Wijga
    Centre for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    BMC Public Health 10:184. 2010

Detail Information

Publications117 found, 100 shown here

  1. pmc Ceramides: a potential therapeutic target in pulmonary emphysema
    Jeroen Tibboel
    Physiology and Experimental Medicine Program, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Respir Res 14:96. 2013
    ..The aim of this manuscript was to characterize airway ceramide profiles in a rodent model of elastase-induced emphysema and to examine the effect of pharmacological intervention directed towards ceramide metabolism...
  2. pmc Early life microbial exposure and fractional exhaled nitric oxide in school-age children: a prospective birth cohort study
    Lidia Casas
    Centre for Research in Environmental Epidemiology CREAL, Barcelona, Spain
    Environ Health 12:103. 2013
    ..In the present work we aimed to evaluate the associations between early life microbial exposures, and fractional exhaled nitric oxide (FeNO) at school age...
  3. pmc Urinary eosinophil protein X in childhood asthma: relation with changes in disease control and eosinophilic airway inflammation
    Marianne Nuijsink
    Department of Pediatric Respiratory Medicine, Juliana Children s Hospital, Haga Teaching Hospital, P O Box 60605, 2506 LP, The Hague, The Netherlands
    Mediators Inflamm 2013:532619. 2013
    ..As the associations were weak and the scatter of uEPX wide, it seems unlikely that uEPX will be useful as a biomarker for monitoring asthma control in the individual child...
  4. pmc Exhaled nitric oxide measurements in the first 2 years of life: methodological issues, clinical and epidemiological applications
    Carmelo Gabriele
    Department of Pediatrics, Salesi Children s Hospital, Azienda Ospedaliero Universitaria Ospedali Riuniti, Ancona, Italy
    Ital J Pediatr 35:21. 2009
    ....
  5. pmc Air pollution, fetal and infant tobacco smoke exposure, and wheezing in preschool children: a population-based prospective birth cohort
    Agnes M M Sonnenschein-van der Voort
    Department of Pediatrics, Division of Respiratory Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Environ Health 11:91. 2012
    ..We examined the associations of exposure to ambient particulate matter (PM10) and nitrogen dioxide (NO2) with the risk of wheezing in preschool children, and assessed whether these associations were modified by tobacco smoke exposure...
  6. pmc Predicting asthma in preschool children with asthma symptoms: study rationale and design
    Esther Hafkamp-de Groen
    The Generation R Study Group, Erasmus MC, Rotterdam, The Netherlands
    BMC Pulm Med 12:65. 2012
    ....
  7. pmc Early respiratory morbidity in a multicultural birth cohort: the Generation R Study
    Carmelo Gabriele
    The Generation R Study Group, Erasmus University Medical Centre, Sophia Children s Hospital, Rotterdam, The Netherlands
    Eur J Epidemiol 27:453-62. 2012
    ..Hence, ethnic background was associated with respiratory symptoms during the first 2 years of life and this association was largely explained by mediating effects of known pre and postnatal risk factors for respiratory morbidity...
  8. doi request reprint Exhaled nitric oxide and the risk of wheezing in infancy: the Generation R Study
    C Gabriele
    Dept of Paediatrics Respiratory Medicine, Erasmus University Medical Center, Rotterdam 3000 CB, The Netherlands
    Eur Respir J 39:567-72. 2012
    ..We conclude that F(eNO) at 6 months is positively associated with the risk of wheezing, but has limited added value in predicting wheezing in the second year of life in individual children...
  9. pmc Quantification of the energy gap in young overweight children. The PIAMA birth cohort study
    Saskia W van den Berg
    National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    BMC Public Health 11:326. 2011
    ..Aim of this study was to quantify the positive energy balance responsible for excess body weight gain (energy gap) in young overweight children...
  10. pmc Comorbidities of obesity in school children: a cross-sectional study in the PIAMA birth cohort
    Alet H Wijga
    Centre for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    BMC Public Health 10:184. 2010
    ..There is ample evidence that childhood overweight is associated with increased risk of chronic disease in adulthood. The aim of this study was to investigate associations between childhood overweight and common childhood health problems...
  11. pmc Early detection and counselling intervention of asthma symptoms in preschool children: study design of a cluster randomised controlled trial
    Esther Hafkamp-de Groen
    The Generation R Study Group, Erasmus MC, Rotterdam, The Netherlands
    BMC Public Health 10:555. 2010
    ..Early detection and counselling is expected to reduce the prevalence of asthma symptoms and improve health-related quality of life at age 6 years...
  12. pmc Do parents who smoke underutilize health care services for their children? A cross sectional study within the longitudinal PIAMA study
    Monique A M Jacobs-van der Bruggen
    National Institute of Public Health and the Environment RIVM, Bilthoven, The Netherlands
    BMC Health Serv Res 7:83. 2007
    ..This study explores the validity and generalizability of the previous assumption...
  13. pmc Randomized double-blind placebo-controlled trial of sublingual immunotherapy in children with house dust mite allergy in primary care: study design and recruitment
    Cindy M A de Bot
    Department of General Practice, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    BMC Fam Pract 9:59. 2008
    ..Described here are the methodology, recruitment phases, and main characteristics of the recruited children...
  14. doi request reprint Daily telemonitoring of exhaled nitric oxide and symptoms in the treatment of childhood asthma
    Johan C de Jongste
    Division of Pediatric Respiratory Medicine, Department of Pediatrics, Erasmus University Medical Center Sophia Children s Hospital, P O Box 2060, 3000 CB Rotterdam, The Netherlands
    Am J Respir Crit Care Med 179:93-7. 2009
    ..Asthma treatment might improve when inhaled steroids are titrated on airway inflammation. Fractional exhaled nitric oxide (FeNO0.05), a marker of eosinophilic airway inflammation, can be measured at home...
  15. pmc Cough . 2: Chronic cough in children
    J C de Jongste
    Department of Pediatric Respiratory Medicine, Sophia Children s Hospital Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Thorax 58:998-1003. 2003
    ..More or less specific diagnoses in children include cystic fibrosis, aspirated foreign body, congenital anatomic abnormalities and primary ciliary dyskinesia...
  16. ncbi request reprint [The practice guideline 'Asthma in children' (second revision) from the Dutch College of General Practitioners; a response from the perspective of paediatric pulmonology]
    J C de Jongste
    Erasmus MC Sophia Kinderziekenhuis, afd Kindergeneeskunde, Postbus 2060, 3000 CB Rotterdam
    Ned Tijdschr Geneeskd 152:543-5. 2008
    ....
  17. ncbi request reprint Comparison of maximal bronchoconstriction in vivo and airway smooth muscle responses in vitro in nonasthmatic humans
    J C de Jongste
    Department of Paediatric Respiratory Diseases, University Hospital Sophia Children s Hospital, Rotterdam, The Netherlands
    Am Rev Respir Dis 138:321-6. 1988
    ..The severity of SAD was significantly correlated with the degree of baseline airflow limitation (p less than 0.05), but not with in vivo or in vitro responses to methacholine.(ABSTRACT TRUNCATED AT 250 WORDS)..
  18. ncbi request reprint Effects of changes in osmolarity on isolated human airways
    R C Jongejan
    Department of Pediatric Respiratory Medicine, Erasmus University, Rotterdam, The Netherlands
    J Appl Physiol (1985) 68:1568-75. 1990
    ....
  19. ncbi request reprint Physiological and morphological determinants of maximal expiratory flow in chronic obstructive lung disease
    H A Tiddens
    Dept of Pediatrics, Erasmus University, Rotterdam, The Netherlands
    Eur Respir J 9:1785-94. 1996
    ..We conclude that the maximal flow-static recoil model does not adequately reflect the collapsibility of the flow-limiting segment...
  20. ncbi request reprint Relaxation of human peripheral airway smooth muscle in vitro does not correlate with severity of chronic airflow limitation in vivo
    J C de Jongste
    Department of Paediatric Pulmonology, Erasmus University, Rotterdam, The Netherlands
    Pulm Pharmacol 2:75-9. 1989
    ..These results suggest that airflow limitation in COPD is not associated with an impaired relaxability of peripheral airway smooth muscle...
  21. ncbi request reprint Effects of inflammatory mediators on the responsiveness of isolated human airways to methacholine
    R C Jongejan
    Division of Pediatric Respiratory Medicine, Erasmus University, Rotterdam, The Netherlands
    Am Rev Respir Dis 142:1129-32. 1990
    ..05, ANOVA). These data indicate that mediator-induced muscle hypersensitivity can explain a small part of the leftward shift of the dose-response curve to inhaled MCh as observed in asthma...
  22. doi request reprint Interaction of a 17q12 variant with both fetal and infant smoke exposure in the development of childhood asthma-like symptoms
    R J P van der Valk
    The Generation R Study Group, Erasmus University Medical Center, Rotterdam, The Netherlands
    Allergy 67:767-74. 2012
    ..Gene variants on chromosome 17q12-21 are associated with an increased risk of childhood-onset asthma, a risk known to be modified by environmental tobacco smoke (ETS)...
  23. doi request reprint Childhood wheezing phenotypes and FeNO in atopic children at age 8
    R J P van der Valk
    Department of Pediatrics, Erasmus University Medical Center, Sophia Children s Hospital, Rotterdam, The Netherlands
    Clin Exp Allergy 42:1329-36. 2012
    ..Using longitudinal latent class analysis, five wheezing phenotypes have been identified, characterized by different ages of onset and prognosis...
  24. ncbi request reprint Interrupter resistance in preschool children: measurement characteristics and reference values
    P J Merkus
    Department of Paediatrics, Subdivision of Respiratory Medicine, Sophia Children s Hospital, Erasmus University and University Hospital, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands
    Am J Respir Crit Care Med 163:1350-5. 2001
    ..The same applied to interobserver agreement (intraclass correlation 0.98). The interrupter technique proves to be a reliable and practical test of airway function, suitable for clinical and epidemiologic studies in preschool children...
  25. ncbi request reprint Flow-dependency of exhaled nitric oxide in children with asthma and cystic fibrosis
    A Kroesbergen
    Erasmus Medical Center Sophia Children s Hospital, Dept of Paediatrics, Rotterdam, The Netherlands
    Eur Respir J 14:871-5. 1999
    ..Assessment of the nitric oxide/flow relationship may help in separating asthmatics from normal children...
  26. ncbi request reprint Activated human granulocytes contract isolated human airways
    R C Jongejan
    Department of Pediatrics, Erasmus University Sophia Children s Hospital, Rotterdam, The Netherlands
    Agents Actions Suppl 31:127-31. 1990
    ..This suggests that eosinophils rather than neutrophils are implicated in this response, which seems to be caused by LTC4/D4...
  27. doi request reprint Perinatal risk factors for wheezing phenotypes in the first 8 years of life
    D Caudri
    Department of Pediatrics Respiratory Medicine, Erasmus University Medical Center Sophia Children s Hospital, Rotterdam, The Netherlands
    Clin Exp Allergy 43:1395-405. 2013
    ..Five phenotypes were identified: never/infrequent wheeze, transient early wheeze, intermediate onset wheeze, persistent wheeze and late onset wheeze. It is unknown which perinatal risk factors drive development of these phenotypes...
  28. pmc Exhaled nitric oxide predicts asthma relapse in children with clinical asthma remission
    M W Pijnenburg
    Department of Paediatrics Paediatric Respiratory Medicine, Erasmus Medical Centre Sophia Children s Hospital, P O Box 2060, 3000 CB Rotterdam, The Netherlands
    Thorax 60:215-8. 2005
    ..A study was undertaken to determine whether FE(NO) predicts asthma relapse in asymptomatic asthmatic children in whom inhaled corticosteroids are discontinued...
  29. ncbi request reprint Nonneural components in the response of fresh human airways to electric field stimulation
    J C de Jongste
    Department of Pediatric Respiratory Diseases, Erasmus University, Rotterdam, The Netherlands
    J Appl Physiol 63:1558-66. 1987
    ....
  30. ncbi request reprint Respiratory infections in infants: interaction of parental allergy, child care, and siblings-- The PIAMA study
    L P Koopman
    Department of Pediatrics, Sophia Children s Hospital, Erasmus University, Rotterdam, The Netherlands
    Pediatrics 108:943-8. 2001
    ..To investigate the association between contacts with other children and the development of respiratory infections in the first year of life in children with or without genetic predisposition for allergy...
  31. pmc Controlled low flow off line sampling of exhaled nitric oxide in children
    Q Jöbsis
    Department of Paediatrics, Division of Paediatric Respiratory Medicine, Erasmus University Medical Center Sophia Children s Hospital, Rotterdam, The Netherlands
    Thorax 56:285-9. 2001
    ....
  32. pmc Urinary eosinophil protein X in children with atopic asthma
    M Nuijsink
    Department of Paediatric Respiratory Medicine, Juliana Children s Hospital, P O Box 60605, 2506 LP The Hague, The Netherlands
    Mediators Inflamm 2007:49240. 2007
    ..The aim of this study was to investigate the relationship between urinary eosinophil protein X (uEPX) and asthma symptoms, lung function, and other markers of eosinophilic airway inflammation in asthmatic school children...
  33. ncbi request reprint Nasal nitric oxide in cystic fibrosis with and without humming
    V M D Struben
    Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Clin Invest 37:140-4. 2007
    ..Humming nNO values have not been reported in CF patients yet. Our aim was to explore humming nNO values in CF patients and assess whether nNO during humming is a better discriminator than silent nNO measurements in this patient group...
  34. ncbi request reprint Effect of cooling on responses of isolated human airways to pharmacologic and electrical stimulation
    R C Jongejan
    Department of Pediatric Pulmonary Medicine, Erasmus University, Rotterdam, The Netherlands
    Am Rev Respir Dis 143:369-74. 1991
    ..However, cooling increases the sensitivity to EFS-induced relaxation and might facilitate the accumulation of leukotriene C4/D4 in the airway wall.(ABSTRACT TRUNCATED AT 250 WORDS)..
  35. ncbi request reprint Effects of cooling on in vitro responses of human peripheral airways to inflammatory mediators and neurotransmitters
    R C Jongejan
    Department of Paediatric Respiratory Diseases, Erasmus University, Rotterdam, The Netherlands
    Agents Actions 26:73-4. 1989
    ..We conclude that cooling does not sensitize human airways to any of these agonists and that cold-induced bronchoconstriction in vivo is not due to a direct effect of cooling on airway smooth muscle...
  36. ncbi request reprint Electrically stimulated Krebs-Henseleit buffer does not relax precontracted human bronchi in vitro
    R C Jongejan
    Department of Paediatric Respiratory Diseases, Erasmus University, Rotterdam, The Netherlands
    Agents Actions 26:75-6. 1989
    ..We conclude that in oxygenated Krebs buffer EFS does not cause generation of substances that change the contractile state of prestimulated human airways...
  37. ncbi request reprint Measurement of human small airway smooth muscle function in vitro. Comparison of bronchiolar strips and segments
    R C Jongejan
    Department of Paediatric Respiratory Diseases, Erasmus University, Rotterdam, The Netherlands
    J Pharmacol Methods 20:135-42. 1988
    ..We concluded that, although human bronchiolar strips and segments are functionally comparable, bronchiolar segments are preferable because of their practical and theoretical advantages over bronchiolar strips...
  38. ncbi request reprint Off-line sampling of exhaled air for nitric oxide measurement in children: methodological aspects
    Q Jöbsis
    Dept of Paediatrics, Erasmus University and University Hospital, Rotterdam, The Netherlands
    Eur Respir J 17:898-903. 2001
    ..Wearing a noseclip and breath-holding affected measured values and should, therefore be standardized or, preferably, avoided...
  39. doi request reprint Neonatal folate, homocysteine, vitamin B12 levels and methylenetetrahydrofolate reductase variants in childhood asthma and eczema
    R J P van der Valk
    The Generation R Study Group, Erasmus MC, Rotterdam, The Netherlands
    Allergy 68:788-95. 2013
    ..To assess the associations of folate, homocysteine and vitamin B12 levels of children at birth and their methylenetetrahydrofolate reductase (MTHFR) variants with asthma and eczema in childhood...
  40. ncbi request reprint High fractional concentration of nitric oxide in exhaled air despite steroid treatment in asthmatic children
    M W H Pijnenburg
    Department of Paediatric Respiratory Medicine, Erasmus University Medical Centre Rotterdam Sophia Children s Hospital, Rotterdam, The Netherlands
    Clin Exp Allergy 35:920-5. 2005
    ..However, some patients have persistently high FENO levels despite treatment...
  41. ncbi request reprint Adolescents in clinical remission of atopic asthma have elevated exhaled nitric oxide levels and bronchial hyperresponsiveness
    L M van den Toorn
    Departments of Paediatrics Paediatric Respiratory Medicine and Pulmonary Medicine, Sophia Children s Hospital and Erasmus University University Hospital, Rotterdam, The Netherlands
    Am J Respir Crit Care Med 162:953-7. 2000
    ..We speculate that subclinical inflammation is a risk factor for asthma relapse later in life, and that eNO and responsiveness to both AMP and MCh can be used as different, noninvasive indices of the inflammatory process of the airways...
  42. ncbi request reprint Exhaled nitric oxide in infants--what is a nice test like FENO doing in a place like this?
    Esther van Mastrigt
    Department of Pediatrics Respiratory Medicine, Erasmus University Medical Centre Sophia Children s Hospital, Rotterdam, The Netherlands
    Semin Respir Crit Care Med 28:264-71. 2007
    ..There is a need for clinical studies showing the merits and limitations of different methodologies, to standardize FENO measurements in infants, and to obtain normal reference values for this age group...
  43. doi request reprint Maternal fish consumption during pregnancy and risks of wheezing and eczema in childhood: the Generation R Study
    E T M Leermakers
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Clin Nutr 67:353-9. 2013
    ..In Generation R, a prospective cohort study in the Netherlands, we examined the associations of first trimester fish consumption with childhood wheezing and eczema in the first 4 years of life...
  44. ncbi request reprint Compliance, hysteresis, and collapsibility of human small airways
    H A Tiddens
    Department of Pediatrics, Division of Respiratory Medicine, Sophia Children s Hospital, Rotterdam, The Netherlands
    Am J Respir Crit Care Med 160:1110-8. 1999
    ..5, p = 0.05). We conclude that, in this study, smooth muscle area and smooth muscle tone, but not total wall area, are determinants for compliance, hysteresis, and collapsibility of isolated airways obtained from smokers...
  45. ncbi request reprint Additive effect of epithelial denudation and low levels of inflammatory mediators on the sensitivity of isolated human airways to methacholine
    R C Jongejan
    Department of Pediatrics, Erasmus University Sophia Children s Hospital, Rotterdam, The Netherlands
    Agents Actions Suppl 31:279-82. 1990
    ..This raises the possibility that these factors play a role in the pathogenesis of bronchial hyperresponsiveness to inhaled methacholine in asthma...
  46. doi request reprint Smoke exposure, airway symptoms and exhaled nitric oxide in infants: the Generation R study
    C Gabriele
    Dept of Paediatric Respiratory Medicine, Erasmus University Medical Center, Sophia Children s Hospital, The Netherlands
    Eur Respir J 32:307-13. 2008
    ..The occurrence and the severity of respiratory symptoms in the first 2 months of life are associated with lower exhaled nitric oxide fraction...
  47. ncbi request reprint Long-term asthma treatment guided by airway hyperresponsiveness in children: a randomised controlled trial
    M Nuijsink
    Department of Paediatric Respiratory Medicine, Juliana Children s Hospital, The Hague, The Netherlands
    Eur Respir J 30:457-66. 2007
    ....
  48. doi request reprint Daily exhaled nitric oxide measurements and asthma exacerbations in children
    R J P van der Valk
    Department of Pediatrics, Erasmus University Medical Center Sophia Children s Hospital, Rotterdam, The Netherlands
    Allergy 67:265-71. 2012
    ..Fractional exhaled Nitric Oxide (FeNO) is a biomarker for eosinophilic airway inflammation and can be measured at home on a daily basis. A short-term increase in FeNO may indicate a higher risk of future asthma exacerbations...
  49. ncbi request reprint Nasal NO measurement by direct sampling from the nose during breathhold: Aspiration flow, nasal resistance and reproducibility
    V M D Struben
    Department of Oto Rhino Laryngology, Erasmus Medical Centre, University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Eur Arch Otorhinolaryngol 263:723-8. 2006
    ..nNO can be measured in either nostril and shows no diurnal variation. The measurement is quick, reproducible, feasible and best accepted with an aspiration flow of 700 ml/min during breathhold for 10 s...
  50. ncbi request reprint Leukotriene generation and small airway smooth muscle responsiveness in human lung
    J C de Jongste
    Department of Paediatric Pulmonology, Erasmus University, Rotterdam Sophia Children s Hospital, Rotterdam, The Netherlands
    Prostaglandins Leukot Essent Fatty Acids 34:31-6. 1988
    ..These findings suggest that the responsiveness of human peripheral airway smooth muscle to LT is not related to the capacity of the lung tissue to synthetize LT...
  51. doi request reprint Maternal fatty acid levels during pregnancy, childhood lung function and atopic diseases. The Generation R Study
    E Rucci
    The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Clin Exp Allergy 46:461-71. 2016
    ..Maternal fatty acid status during pregnancy might influence foetal immunological development and subsequently the risk of childhood atopic diseases...
  52. ncbi request reprint Recombinant human deoxyribonuclease for the treatment of acute asthma in children
    R Boogaard
    Department of Pediatric Pulmonology, Erasmus MC Sophia Children s Hospital, Rotterdam, P O Box 2060, 3000 CB Rotterdam, The Netherlands
    Thorax 63:141-6. 2008
    ..The aim of this study was to determine the efficacy of the mucolytic drug recombinant human deoxyribonuclease (rhDNase) in addition to standard treatment at the emergency department in children with an asthma exacerbation...
  53. ncbi request reprint Effects of zymosan-activated human granulocytes on isolated human airways
    R C Jongejan
    Department of Pediatrics, Erasmus University and University Hospital Rotterdam Sophia Children s Hospital, The Netherlands
    Am Rev Respir Dis 143:553-60. 1991
    ..66, p less than 0.01). The sensitivity of the airways to methacholine was unchanged in the presence of 1, 2, or 5 x 10(6) ZAG and decreased with 10 or 20 x 10(6) ZAG (p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)..
  54. ncbi request reprint Exhaled nitric oxide in childhood asthma: a review
    M W H Pijnenburg
    Department of Paediatrics Paediatric Respiratory Medicine, Erasmus University Medical Centre Sophia Children s Hospital, Rotterdam, The Netherlands
    Clin Exp Allergy 38:246-59. 2008
    ..In pre-school children Fe(NO) may be of help in the differential diagnosis of respiratory symptoms, and may potentially allow for better targeting and monitoring of anti-inflammatory treatment...
  55. pmc Helicobacter pylori in children with asthmatic conditions at school age, and their mothers
    W J den Hollander
    Department of Gastroenterology and Hepatology, Erasmus University Medical Centre, Rotterdam, The Netherlands
    Aliment Pharmacol Ther . 2016
    ..Helicobacter pylori prevalence in Western countries has been declining simultaneously with increases in childhood asthma and allergic diseases; prior studies have linked these phenomena...
  56. pmc Effects of hyperosmolarity on human isolated central airways
    R C Jongejan
    Department of Pediatrics, Erasmus University, Rotterdam, The Netherlands
    Br J Pharmacol 102:931-7. 1991
    ..The mechanism of the relaxation phase may be an unknown smooth muscle relaxing substance or a direct effect on the airway muscle, related to ion fluxes...
  57. pmc Adverse health effects of prenatal and postnatal tobacco smoke exposure on children
    W Hofhuis
    Erasmus MC, University Medical Centre Rotterdam, Sophia Children s Hospital, Rotterdam, Netherlands
    Arch Dis Child 88:1086-90. 2003
    ..It offers paediatricians, obstetricians, specialists in preventive child health care, general practitioners, and midwives an approach to promote smoking cessation in smoking parents before, during, and after pregnancy...
  58. doi request reprint Exercise capacity, daily activity, and severity of fatigue in term born young adults after neonatal respiratory failure
    M H M van der Cammen-van Zijp
    Intensive Care and Department of Pediatric Surgery, and Department of Rehabilitation Medicine and Physical Therapy, ErasmusMC Sophia Children s Hospital, Rotterdam, The Netherlands
    Scand J Med Sci Sports 24:144-51. 2014
    ..There were no significant associations between exercise capacity and perinatal characteristics. Future studies need to elucidate whether exercise capacity is impaired in patients with more severe lung hypoplasia who nowadays survive...
  59. pmc Bronchodilation in infants with malacia or recurrent wheeze
    W Hofhuis
    Department of Paediatrics, Division of Respiratory Medicine, Erasmus University Medical Centre, Sophia Children s Hospital, Rotterdam, Netherlands
    Arch Dis Child 88:246-9. 2003
    ..Controversy remains regarding the effectiveness of bronchodilators in wheezy infants...
  60. ncbi request reprint Definition of respiratory symptoms and disease in early childhood in large prospective birth cohort studies that predict the development of asthma
    L P Koopman
    Erasmus University and University Hospital/Sophia Children's Hospital, Department of Pediatrics, 3000 CB Rotterdam, The Netherlands
    Pediatr Allergy Immunol 12:118-24. 2001
    ..This is an important observation because it implies that comparisons between studies can be markedly improved by data sharing among investigators...
  61. ncbi request reprint Perinatal characteristics and obstetric complications as risk factors for asthma, allergy and eczema at the age of 6 years
    R M D Bernsen
    The Netherlands Department of General Practice, Erasmus MC University Medical Center Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Clin Exp Allergy 35:1135-40. 2005
    ..Considerable effort has been put into identifying early determinants for atopic disorders. Many studies have evaluated the role of fetal development and obstetric complications. However, the results are not unequivocal...
  62. ncbi request reprint Lower risk of atopic disorders in whole cell pertussis-vaccinated children
    R M D Bernsen
    Dept of General Practice, Erasmus MC University Medical Center Rotterdam, The Netherlands
    Eur Respir J 22:962-4. 2003
    ..Whole cell pertussis vaccination is associated with a lower risk of atopic disorders, though other vaccine components (diphtheria, tetanus, poliomyelitis) or other vaccinations may also be involved...
  63. ncbi request reprint [Negative effects of passive smoking on the (unborn) child]
    W Hofhuis
    Erasmus Medisch Centrum, Sophia Kinderziekenhuis, afd Longziekten, Postbus 2060, 3000 CB Rotterdam
    Ned Tijdschr Geneeskd 146:356-9. 2002
    ..This extensive knowledge about the adverse health effects of smoke exposure in (unborn) children deserves greater attention in the counselling of pregnant women, and in anti-smoking campaigns...
  64. ncbi request reprint Responsiveness, longitudinal- and cross-sectional construct validity of the Pediatric Asthma Quality of Life Questionnaire (PAQLQ) in Dutch children with asthma
    H Raat
    Department of Public Health, Erasmus MC University Medical Center Rotterdam, The Netherlands
    Qual Life Res 14:265-72. 2005
    ..In this study, we assessed psychometric properties, responsiveness, and longitudinal and cross-sectional construct validity of the Dutch version of the 23-item Pediatric Asthma Quality of Life Questionnaire (PAQLQ)...
  65. ncbi request reprint Influenza vaccination in asthmatic children: effects on quality of life and symptoms
    H J Bueving
    Dept of General Practice, room Ff305, Erasmus MC University Medical Center Rotterdam, PO Box, 1738, The Netherlands
    Eur Respir J 24:925-31. 2004
    ..Influenza vaccination was found to have a moderately beneficial effect on quality of life in influenza-positive weeks of illness in children with asthma...
  66. ncbi request reprint [Airway malacia: not uncommon in children with atypical respiratory symptoms]
    R Boogaard
    Erasmus MC Sophia Kinderziekenhuis, afd Kindergeneeskunde, sub afd Kinderlongziekten, Rotterdam
    Ned Tijdschr Geneeskd 150:2037-42. 2006
    ..To estimate the prevalence of primary airway malacia at birth, determine the predictive value of a clinical diagnosis of airway malacia compared with bronchoscopy results and describe the presenting symptoms...
  67. doi request reprint Associations of maternal and fetal 25-hydroxyvitamin D levels with childhood lung function and asthma: the Generation R Study
    T Gazibara
    The Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Clin Exp Allergy 46:337-46. 2016
    ..Exposure to low levels of vitamin D in fetal life might be a risk factor for childhood asthma...
  68. doi request reprint Duration and exclusiveness of breastfeeding and childhood asthma-related symptoms
    A M M Sonnenschein-van der Voort
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur Respir J 39:81-9. 2012
    ..These associations seemed, at least partly, to be explained by infectious, but not by atopic, mechanisms...
  69. doi request reprint Skin tests, T cell responses and self-reported symptoms in children with allergic rhinitis and asthma due to house dust mite allergy
    H Moed
    Department of General Practice, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Clin Exp Allergy 39:222-7. 2009
    ..During the late phase, eosinophils and T cells infiltrate the mucosa and play an important role in inflammation...
  70. ncbi request reprint Exhaled nitric oxide measurements with dynamic flow restriction in children aged 4-8 yrs
    M W H Pijnenburg
    Dept of Paediatrics Respiratory Medicine, Erasmus MC University Medical Center Sophia Children s Hospital, Rotterdam, The Netherlands
    Eur Respir J 20:919-24. 2002
    ..6+/-1.1 ppb for female children. It can be concluded that off-line fraction of exhaled nitric oxide measurements with dynamic flow restriction are feasible in young children and correspond to on-line values...
  71. doi request reprint Deterioration of exercise capacity after neonatal extracorporeal membrane oxygenation
    M H M van der Cammen-van Zijp
    Depts of Intensive Care, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Eur Respir J 38:1098-104. 2011
    ..We therefore propose prolonged follow-up. Proactive advice on sports participation or referral to a physical therapist is recommended, especially when either the parents or the children themselves report impaired exercise capacity...
  72. doi request reprint Exhaled breath profiling using broadband quantum cascade laser-based spectroscopy in healthy children and children with asthma and cystic fibrosis
    E van Mastrigt
    Department of Pediatrics, Division Pediatric Respiratory Medicine, Erasmus University Medical Center Sophia Children s Hospital, Sp 3435, PO Box 2060, 3000 CB, Rotterdam, The Netherlands
    J Breath Res 10:026003. 2016
    ....
  73. ncbi request reprint Bacteria and mould components in house dust and children's allergic sensitisation
    U Gehring
    Utrecht University, Institute for Risk Assessment Sciences, PO Box 80178, 3508 TD Utrecht, and Sophia Children s Hospital, Rotterdam, The Netherlands
    Eur Respir J 29:1144-53. 2007
    ..It is not possible to distinguish with certainty which component relates to the effect, since their levels are highly correlated...
  74. doi request reprint Internet-based self-management compared with usual care in adolescents with asthma: a randomized controlled trial
    E R V M Rikkers-Mutsaerts
    Department of Pediatrics, Leiden University Medical Centre, Leiden, The Netherlands
    Pediatr Pulmonol 47:1170-9. 2012
    ..Internet-based self-management (IBSM) improves asthma-related quality of life in adults. We hypothesized that IBSM improves asthma-related quality of life in adolescents...
  75. ncbi request reprint Measurements of interrupter resistance: reference values for children 3-13 yrs of age
    P J F M Merkus
    Dept of Paediatrics, Sophia Children s Hospital, Erasmus University Medical Centre Rotterdam, The Netherlands
    Eur Respir J 20:907-11. 2002
    ..645-0.00668x standing height (cm) kPa x L(-1) x s(-1) and residual SD (0.093 kPa x L(-1) x s(-1)). Expiratory interrupter resistance provides a tool for clinical and epidemiological assessment of airway function in a large age range...
  76. pmc Is there an association between wheezing and constipation in preschool children? Explanations from a longitudinal birth cohort
    J C Kiefte-de Jong
    The Generation R Study Group, Erasmus Medical Centre, Rotterdam, The Netherlands
    BMJ Open 1:e000237. 2011
    ..Therefore, an independent association between respiratory symptoms and functional bowel disorders as suggested in previous studies is questionable...
  77. ncbi request reprint Studies of human airways in vitro: a review of the methodology
    A R Hulsmann
    Department of Pediatrics, Sophia Children s Hospital Rotterdam, The Netherlands
    J Pharmacol Toxicol Methods 30:117-32. 1993
    ..Commonly used physiological salt solutions which bath the tissue contain osmotic molecules, ions important for contractility, glucose as a substrate, and a bicarbonate-carbon dioxide buffer.(ABSTRACT TRUNCATED AT 400 WORDS)..
  78. ncbi request reprint Computed critiquing integrated into daily clinical practice affects physicians' behavior--a randomized clinical trial with AsthmaCritic
    M M Kuilboer
    Department of Medical Informatics, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Methods Inf Med 45:447-54. 2006
    ..This paper assesses the effect of AsthmaCritic on monitoring and treatment of asthma and COPD by Dutch general practitioners in daily practice...
  79. ncbi request reprint Epidemiological aspects of paediatric asthma
    J Hess
    Department of Paediatrics, Division of Paediatric Respiratory Medicine, Sophia Children s Hospital, Erasmus Medical Centre, Rotterdam, The Netherlands
    Clin Exp Allergy 34:680-5. 2004
  80. doi request reprint Real life data on incidence and risk factors of severe asthma exacerbations in children in primary care
    M Engelkes
    Department of Medical Informatics, Erasmus MC, Rotterdam, The Netherlands
    Respir Med 119:48-54. 2016
    ..25% of the patients with an exacerbation will experience a next exacerbation within 1 year. More severe asthma is a predictor of subsequent and future exacerbations...
  81. doi request reprint The analysis of volatile organic compounds in exhaled breath and biomarkers in exhaled breath condensate in children - clinical tools or scientific toys?
    E van Mastrigt
    Department of Paediatric Respiratory Medicine, Erasmus University Medical Centre Sophia Children s Hospital, Rotterdam, The Netherlands
    Clin Exp Allergy 45:1170-88. 2015
    ..In conclusion, the use of VOCs in EB and biomarkers in EBC as markers of inflammatory airway diseases in children is still a research tool and not validated for clinical use. ..
  82. ncbi request reprint Effect of a facemask leak on aerosol delivery from a pMDI-spacer system
    J E Esposito-Festen
    Department of Pediatrics, Division of Respiratory Medicine, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    J Aerosol Med 17:1-6. 2004
    ..5 cm(2). Efficiency of a pMDI-spacer facemask strongly depends on the size of a facemask leak. Spacer output did not depend on the position of the leak. Lung dose was higher for leaks near the chin than for leaks near the nose...
  83. doi request reprint Asthma control questionnaires in the management of asthma in children: A review
    S Voorend-van Bergen
    Erasmus University Medical Center, Sophia Children s Hospital, Rotterdam, The Netherlands
    Pediatr Pulmonol 50:202-8. 2015
    ....
  84. ncbi request reprint Effectiveness of pharmacotherapy in asthmatic preschool children
    J C de Jongste
    Department of Pediatrics, Division Pediatric Respiratory Medicine, Erasmus University and University Hospital Sophia Children s Hospital, Rotterdam, The Netherlands
    Allergy 57:42-7. 2002
    ..Also, we need methods to separate the different phenotypes within the group of recurrently wheezing preschool children to optimize targeting of asthma treatment to those who have ongoing airway inflammation...
  85. ncbi request reprint Nasal nitric oxide and nasal allergy
    V M D Struben
    Department of Otorhinolaryngology, Erasmus Medical Centre, Rotterdam, The Netherlands
    Allergy 61:665-70. 2006
    ..Subsequently, we examine published data on allergic rhinitis and nNO, and summarize the effect of treatment of rhinitis on nNO. Finally, we discuss the potential future role for nNO in the diagnosis and management of allergic rhinitis...
  86. pmc Hydrogen peroxide in breath condensate during a common cold
    R Q Jöbsis
    Department of Paediatrics, Division of Paediatric Respiratory Medicine, Erasmus University Medical Center Sophia Children s Hospital, Rotterdam, The Netherlands
    Mediators Inflamm 10:351-4. 2001
    ..Hydrogen peroxide (H2O2) in exhaled air condensate is elevated in inflammatory disorders of the lower respiratory tract. It is unknown whether viral colds contribute to exhaled H2O2...
  87. ncbi request reprint Early life circumstances and atopic disorders in childhood
    R M D Bernsen
    Department of General Practice, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Clin Exp Allergy 36:858-65. 2006
    ..Risk factors for the development of these disorders have been studied extensively. This review focuses on the role of early life risk factors such as pre-natal development, perinatal circumstances, birth order and childhood vaccinations...
  88. ncbi request reprint Dyspnoea perception during clinical remission of atopic asthma
    L M van den Toorn
    Dept of Paediatrics Paediatric Respiratory Medicine, Erasmus University Medical Centre, Rotterdam, The Netherlands
    Eur Respir J 19:1047-50. 2002
    ..Other factors, including both physical and psychological ones, may play a role in the apparent absence of symptoms, thereby potentially leading to undertreatment...
  89. pmc Early respiratory and skin symptoms in relation to ethnic background: the importance of socioeconomic status; the PIAMA study
    L P Koopman
    Erasmus University Medical Center Sophia Children s Hospital Rotterdam, Department of Pediatrics National Institute of Public Health and the Environment, Rotterdam, Netherlands
    Arch Dis Child 87:482-8. 2002
    ..To evaluate ethnic differences in the prevalence of respiratory and skin symptoms in the first two years of life...
  90. ncbi request reprint Measurement of exhaled nitric oxide in children, 2001
    E Baraldi
    Dept of Paediatrics, Padova, Italy
    Eur Respir J 20:223-37. 2002
    ..Evidence for clinically-useful applications is accumulating, and the merits of this new technique must now be demonstrated in larger studies, using standardised methodology in an appropriate setting...
  91. pmc Inhaled sodium cromoglycate in children with asthma
    M J A Tasche
    Thorax 57:751-2. 2002
  92. ncbi request reprint Annual lung function changes in young patients with chronic lung disease
    P J F M Merkus
    Dept of Paediatrics, Erasmus Medical Centre Rotterdam, Children s Hospital, The Netherlands
    Eur Respir J 19:886-91. 2002
    ..These findings have implications for patient care and clinical research...
  93. ncbi request reprint Yes to NO: the first studies on exhaled nitric oxide-driven asthma treatment
    J C de Jongste
    Eur Respir J 26:379-81. 2005
  94. ncbi request reprint ['Inflammometry' with nitric oxide in exhaled air: a new test for lung diseases]
    M W Pijnenburg
    Academisch Ziekenhuis Rotterdam-Sophia Kinderziekenhuis, afd. Kindergeneeskunde/Kinderlongziekten, Dr. Molewaterplein 60, 3015 GJ Rotterdam
    Ned Tijdschr Geneeskd 145:946-50. 2001
    ....
  95. ncbi request reprint [New target populations for influenza vaccination; recommendations of the Health Council of the Netherlands]
    H J Bueving
    Ned Tijdschr Geneeskd 151:2749; author reply 2749-50. 2007
  96. pmc Inhaled corticosteroids and long term outcome in adults with asthma
    P J F M Merkus
    Thorax 61:1011. 2006
  97. pmc Exhaled nitric oxide measurements: clinical application and interpretation
    D R Taylor
    Department of Medical and Surgical Sciences, Dunedin School of Medicine, University of Otago, P O Box 913, Dunedin, New Zealand
    Thorax 61:817-27. 2006
    ..However, a number of issues still need to be resolved, including the diagnostic role of F(E)NO in preschool children and the use of reference values versus individual F(E)NO profiles in managing patients with difficult or severe asthma...
  98. ncbi request reprint Exhaled nitric oxide in 4-year-old children: relationship with asthma and atopy
    J E Brussee
    National Institute for Public Health and the Environment, Centre for Prevention and Health Services Research, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Eur Respir J 25:455-61. 2005
    ..This study is one of the few large-scale epidemiological studies among 4-yr-old children from the general population showing that children with symptoms of asthma and atopy have higher levels of exhaled nitric oxide than those without...
  99. ncbi request reprint Airway responsiveness to hypertonic saline: dose-response slope or PD15?
    G de Meer
    Institute for Risk Assessment Sciences, Environmental and Occupational Health, Utrecht University, P Box 80176, 3508 TD Utrecht, The Netherlands
    Eur Respir J 25:153-8. 2005
    ..In conclusion, the continuous relationship between airway responsiveness and asthma symptoms is in favour of a noncensored measure of airway responsiveness, such as the dose-response slope...
  100. ncbi request reprint Nasal NO: normal values in children age 6 through to 17 years
    V M D Struben
    Erasmus Medical Centre Sophia Children s Hospital, Dept Paediatric Respiratory Medicine, Dr Molewaterplein 60, 3015 GD Rotterdam, The Netherlands
    Eur Respir J 26:453-7. 2005
    ..In conclusion, the current study presents normal values for nasal nitric oxide in children, which can be used to assess the value of nasal nitric oxide in respiratory illnesses...
  101. ncbi request reprint Bronchial hyper-responsiveness to hypertonic saline and blood eosinophilic markers in 8-13-year-old schoolchildren
    G de Meer
    Institute for Risk Assessment Sciences, Environmental and Occupational Health, Utrecht University, The Netherlands
    Clin Exp Allergy 34:1226-31. 2004
    ..In adult asthma, bronchial hyper-responsiveness (BHR) to indirect stimuli reflects eosinophilic activation more closely than BHR to stimuli that directly cause smooth muscle contraction...