Marcel J C Bijvelds
Affiliation: Erasmus MC
Country: The Netherlands
- Fat absorption in cystic fibrosis mice is impeded by defective lipolysis and post-lipolytic eventsMarcel J C Bijvelds
Dept of Biochemistry, Erasmus MC, Postbus 1738, NL 3000 DR Rotterdam, The Netherlands
Am J Physiol Gastrointest Liver Physiol 288:G646-53. 2005..We conclude that fat malabsorption in cftr null mice is caused by impairment of lipolysis, which may result from aberrant duodenal pH regulation...
- Activation of CFTR by ASBT-mediated bile salt absorptionMarcel J C Bijvelds
Dept of Biochemistry, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, The Netherlands
Am J Physiol Gastrointest Liver Physiol 289:G870-9. 2005..We conclude that active BS absorption in the ileum triggers CFTR activation and, consequently, local salt and water secretion, which may serve to prevent intestinal obstruction in the postprandial state...
- Activation of intestinal Cl- secretion by lubiprostone requires the cystic fibrosis transmembrane conductance regulatorMarcel J C Bijvelds
Department of Biochemistry, Sophia Children s Hospital, Erasmus MC, Rotterdam, The Netherlands
Gastroenterology 137:976-85. 2009..Because ClC-2 recruitment might be beneficial to CF patients, we investigated lubiprostone's mode of action...
- Guanylin and uroguanylin are produced by mouse intestinal epithelial cells of columnar and secretory lineagePauline T Ikpa
Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
Histochem Cell Biol 146:445-55. 2016..Our study reveals novel aspects of the cellular localization of the GCC signaling axis that, apart from its role in the regulation of fluid balance, link it to pH regulation, cell cycle control, and host defense. ..
- Inhibition of Heat-Stable Toxin-Induced Intestinal Salt and Water Secretion by a Novel Class of Guanylyl Cyclase C InhibitorsMarcel J C Bijvelds
Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
J Infect Dis 212:1806-15. 2015..We set out to identify GCC inhibitors that may be of benefit for the treatment of infectious diarrheal disease...