G Koopman

Summary

Affiliation: Biomedical Primate Research Centre
Country: The Netherlands

Publications

  1. pmc Clearance of genotype 1b hepatitis C virus in chimpanzees in the presence of vaccine-induced E1-neutralizing antibodies
    Babs E Verstrepen
    Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    J Infect Dis 204:837-44. 2011
  2. pmc Strong vaccine-induced CD8 T-cell responses have cytolytic function in a chimpanzee clearing HCV infection
    Babs E Verstrepen
    Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    PLoS ONE 9:e95103. 2014
  3. ncbi Vaccine protection from CD4+ T-cell loss caused by simian immunodeficiency virus (SIV) mac251 is afforded by sequential immunization with three unrelated vaccine vectors encoding multiple SIV antigens
    Gerrit Koopman
    Department of Virology, Biomedical Primate Research Centre, Lange Kleiweg 139, 2288 GJ Rijswijk, The Netherlands
    J Gen Virol 85:2915-24. 2004
  4. ncbi Increase in plasmacytoid and myeloid dendritic cells by progenipoietin-1, a chimeric Flt-3 and G-CSF receptor agonist, in SIV-Infected rhesus macaques
    Gerrit Koopman
    BPRC, Rijswijk, The Netherlands
    Hum Immunol 65:303-16. 2004
  5. ncbi Systemic mobilization of antigen presenting cells, with a chimeric Flt-3 and G-CSF receptor agonist, during immunization of Macaca mulatta with HIV-1 antigens is insufficient to modulate immune responses or vaccine efficacy
    Gerrit Koopman
    Biomedical Primate Research Center, Department of Virology, Lange Kleiweg 139, 2288 GJ Rijswijk, The Netherlands
    Vaccine 23:4195-202. 2005
  6. ncbi Decreased expression of IL-2 in central and effector CD4 memory cells during progression to AIDS in rhesus macaques
    G Koopman
    Biomedical Primate Research Centre, Department of Virology, Rijswijk, The Netherlands
    AIDS 15:2359-69. 2001
  7. doi Acute-phase CD4+ T-cell proliferation and CD152 upregulation predict set-point virus replication in vaccinated simian-human immunodeficiency virus strain 89.6p-infected macaques
    Gerrit Koopman
    Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    J Gen Virol 90:915-26. 2009
  8. ncbi Changes in dendritic cell subsets in the lymph nodes of rhesus macaques after application of glucocorticoids
    G Koopman
    Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    Hum Immunol 62:208-14. 2001
  9. doi Immune-response profiles induced by human immunodeficiency virus type 1 vaccine DNA, protein or mixed-modality immunization: increased protection from pathogenic simian-human immunodeficiency virus viraemia with protein/DNA combination
    Gerrit Koopman
    Department of Virology, Biomedical Primate Research Center BPRC, 2288 GH Rijswijk, The Netherlands
    J Gen Virol 89:540-53. 2008
  10. ncbi CD44 isoforms, including the CD44 V3 variant, are expressed on endothelium, suggesting a role for CD44 in the immobilization of growth factors and the regulation of the local immune response
    G Koopman
    Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands
    Biochem Biophys Res Commun 245:172-6. 1998

Collaborators

Detail Information

Publications39

  1. pmc Clearance of genotype 1b hepatitis C virus in chimpanzees in the presence of vaccine-induced E1-neutralizing antibodies
    Babs E Verstrepen
    Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    J Infect Dis 204:837-44. 2011
    ..Unexpectedly, the capacity to neutralize HCV was observed in E1 but not in animals immunized with E2 devoid of HVR-1. Furthermore, in vivo only E1-vaccinated animals exposed to the heterologous HCV-1b inoculum cleared HCV infection...
  2. pmc Strong vaccine-induced CD8 T-cell responses have cytolytic function in a chimpanzee clearing HCV infection
    Babs E Verstrepen
    Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    PLoS ONE 9:e95103. 2014
    ..In conclusion, in the animal that was able to clear HCV infection not only cytokine production was observed but also cytolytic potential against specific MHC class I/peptide-combinations...
  3. ncbi Vaccine protection from CD4+ T-cell loss caused by simian immunodeficiency virus (SIV) mac251 is afforded by sequential immunization with three unrelated vaccine vectors encoding multiple SIV antigens
    Gerrit Koopman
    Department of Virology, Biomedical Primate Research Centre, Lange Kleiweg 139, 2288 GJ Rijswijk, The Netherlands
    J Gen Virol 85:2915-24. 2004
    ..Although limited in the number of animals, this study provides important proof of the efficacy of the triple-vector vaccine strategy against chronic, progressive CD4+ T-cell loss in the rigorous SIVmac/rhesus macaque model of AIDS...
  4. ncbi Increase in plasmacytoid and myeloid dendritic cells by progenipoietin-1, a chimeric Flt-3 and G-CSF receptor agonist, in SIV-Infected rhesus macaques
    Gerrit Koopman
    BPRC, Rijswijk, The Netherlands
    Hum Immunol 65:303-16. 2004
    ..In conclusion, ProGP-1 may be used to generate a transient increase in DC as well as CD4 T-cell numbers, thereby creating a window of opportunity for immunotherapeutic intervention...
  5. ncbi Systemic mobilization of antigen presenting cells, with a chimeric Flt-3 and G-CSF receptor agonist, during immunization of Macaca mulatta with HIV-1 antigens is insufficient to modulate immune responses or vaccine efficacy
    Gerrit Koopman
    Biomedical Primate Research Center, Department of Virology, Lange Kleiweg 139, 2288 GJ Rijswijk, The Netherlands
    Vaccine 23:4195-202. 2005
    ..We conclude that besides mobilization of dendritic cells additional stimuli to induce dendritic cell maturation may be needed for avid boosting of antigen specific immune activation...
  6. ncbi Decreased expression of IL-2 in central and effector CD4 memory cells during progression to AIDS in rhesus macaques
    G Koopman
    Biomedical Primate Research Centre, Department of Virology, Rijswijk, The Netherlands
    AIDS 15:2359-69. 2001
    ....
  7. doi Acute-phase CD4+ T-cell proliferation and CD152 upregulation predict set-point virus replication in vaccinated simian-human immunodeficiency virus strain 89.6p-infected macaques
    Gerrit Koopman
    Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    J Gen Virol 90:915-26. 2009
    ..These data highlight a central role for an acute but transient CD4 decrease, as well as CD4(+) T-cell activation, as independent factors for prediction of set-point levels of virus replication...
  8. ncbi Changes in dendritic cell subsets in the lymph nodes of rhesus macaques after application of glucocorticoids
    G Koopman
    Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    Hum Immunol 62:208-14. 2001
    ..These findings suggest that GCC treatment results in the presence of phenotypically more mature APC...
  9. doi Immune-response profiles induced by human immunodeficiency virus type 1 vaccine DNA, protein or mixed-modality immunization: increased protection from pathogenic simian-human immunodeficiency virus viraemia with protein/DNA combination
    Gerrit Koopman
    Department of Virology, Biomedical Primate Research Center BPRC, 2288 GH Rijswijk, The Netherlands
    J Gen Virol 89:540-53. 2008
    ..Interestingly, control of virus replication was associated with increased SIV Nef- and Gag-specific gamma interferon responses observed immediately following challenge...
  10. ncbi CD44 isoforms, including the CD44 V3 variant, are expressed on endothelium, suggesting a role for CD44 in the immobilization of growth factors and the regulation of the local immune response
    G Koopman
    Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands
    Biochem Biophys Res Commun 245:172-6. 1998
    ..Expression of CD44 variants was unaffected by IL-1beta, IL-8, TNFalpha, IFNgamma or IL-4 treatment, indicating either constitutive expression of these variants or involvement of other cytokines in their regulation...
  11. ncbi Comparison of intranasal with targeted lymph node immunization using PR8-Flu ISCOM adjuvanted HIV antigens in macaques
    G Koopman
    Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    J Med Virol 79:474-82. 2007
    ..In conclusion, in contrast to what has been demonstrated in mice, the IN application of PR8-Flu ISCOM did not induce strong immune responses in rhesus macaques unlike those immunized by the TLNI route...
  12. ncbi HIV-1 vaccine-induced immune responses which correlate with protection from SHIV infection: compiled preclinical efficacy data from trials with ten different HIV-1 vaccine candidates
    J Heeney
    Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    Immunol Lett 66:189-95. 1999
    ..Immunity correlated with the magnitude of Nab responses, beta-chemokines and as well as balanced, qualitative T-helper responses...
  13. pmc Adhesion of human B cells to follicular dendritic cells involves both the lymphocyte function-associated antigen 1/intercellular adhesion molecule 1 and very late antigen 4/vascular cell adhesion molecule 1 pathways
    G Koopman
    Department of Pathology, Free University Hospital, Amsterdam, The Netherlands
    J Exp Med 173:1297-304. 1991
    ....
  14. doi Improved HIV-1 specific T-cell responses by short-interval DNA tattooing as compared to intramuscular immunization in non-human primates
    Babs E Verstrepen
    Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    Vaccine 26:3346-51. 2008
    ..These findings in non-human primates suggest that similar results may be observed in humans. Clinical trials are planned to validate tattooing as an optimal method of DNA vaccine delivery in humans...
  15. ncbi The VLA-4/VCAM-1 pathway is involved in lymphocyte adhesion to endothelium in rheumatoid synovium
    A C van Dinther Janssen
    Department of Pathology, Free University Hospital, Amsterdam, The Netherlands
    J Immunol 147:4207-10. 1991
    ..Thus, the VLA-4/VCAM-1 pathway may be of primary importance in mediating lymphocyte adhesion to inflamed endothelium and in lymphocyte homing to rheumatoid synovium...
  16. ncbi A vaccine strategy utilizing a combination of three different chimeric vectors which share specific vaccine antigens
    J L Heeney
    Biomedical Primate Research Centre, Department of Virology, Rijswijk, The Netherlands
    J Med Primatol 29:268-73. 2000
    ....
  17. ncbi Adhesion through the LFA-1 (CD11a/CD18)-ICAM-1 (CD54) and the VLA-4 (CD49d)-VCAM-1 (CD106) pathways prevents apoptosis of germinal center B cells
    G Koopman
    Department of Pathology, University of Amsterdam, The Netherlands
    J Immunol 152:3760-7. 1994
    ..Together, our data strongly suggest that adhesion of B cells via the LFA-1 (CD11a/CD18)-ICAM-1 (CD54) pathway and VLA-4 (CD49d)-VCAM-1 (CD106) pathway contributes to B cell selection...
  18. doi No difference in Gag and Env immune-response profiles between vaccinated and non-vaccinated rhesus macaques that control immunodeficiency virus replication
    Ivonne Nieuwenhuis
    Department of Virology, Biomedical Primate Research Centre BPRC, Rijswijk, The Netherlands
    J Gen Virol 91:2974-84. 2010
    ..Hence, vaccinated animals that become infected, but control infection, appear to establish immune responses that are similar to those elicited by long-term non-progressors...
  19. doi TRIM5 allelic polymorphism in macaque species/populations of different geographic origins: its impact on SIV vaccine studies
    N G de Groot
    Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    Tissue Antigens 78:256-62. 2011
    ..In addition, we have re-evaluated historical samples of rhesus macaques challenged with SIV(mac251), a virus that has been reported to be partially suppressed by particular rhesus macaque TRIM5 variants...
  20. pmc Whole blood stimulation with Toll-like receptor (TLR)-7/8 and TLR-9 agonists induces interleukin-12p40 expression in plasmacytoid dendritic cells in rhesus macaques but not in humans
    G Koopman
    Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    Clin Exp Immunol 174:161-71. 2013
    ..The data show that, in contrast to humans, pDC in macaques are able to express IL-12p40, which could have consequences for evaluation of human vaccine candidates and viral infection...
  21. pmc Activated human lymphocytes and aggressive non-Hodgkin's lymphomas express a homologue of the rat metastasis-associated variant of CD44
    G Koopman
    Department of Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Exp Med 177:897-904. 1993
    ..It is interesting that overexpression of v6 was also found in several aggressive, but not low-grade, non-Hodgkin's lymphomas...
  22. pmc Characteristics of a pathogenic molecular clone of an end-stage serum-derived variant of simian immunodeficiency virus (SIV(F359))
    L Holterman
    Department of Virology, Biomedical Primate Research Centre, 2280 GH Rijswijk, The Netherlands
    J Virol 75:9328-38. 2001
    ....
  23. ncbi Triple check for antigen specificity of B cells during germinal centre reactions
    E Lindhout
    Dept of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, The Netherlands
    Immunol Today 18:573-7. 1997
    ....
  24. pmc Differential CD4+ versus CD8+ T-cell responses elicited by different poxvirus-based human immunodeficiency virus type 1 vaccine candidates provide comparable efficacies in primates
    Petra Mooij
    Department of Virology, Biomedical Primate Research Centre BPRC, P O Box 3306, 2280 GH Rijswijk, The Netherlands
    J Virol 82:2975-88. 2008
    ..In contrast, in this setting, animals with strong vaccine-induced polyfunctional CD4(+) T-cell responses showed efficacies similar to those with stronger CD8(+) T-cell responses...
  25. doi Chimpanzee CD4+ T cells are relatively insensitive to HIV-1 envelope-mediated inhibition of CD154 up-regulation
    Erik Rutjens
    Biomedical Primate Research Centre, Department of Virology, Rijswijk, The Netherlands
    Eur J Immunol 38:1164-72. 2008
    ..Chimpanzee CD4+ T cells are thus less sensitive to the immune-suppressive effect of low-dose HIV-1 envelope protein than human CD4+ T cells...
  26. pmc Systemic neutralizing antibodies induced by long interval mucosally primed systemically boosted immunization correlate with protection from mucosal SHIV challenge
    Willy M J M Bogers
    Department of Virology, Biomedical Primate Research Centre BPRC, P O Box 3306, 2280 GH Rijswijk, The Netherlands
    Virology 382:217-25. 2008
    ..Vaccine induced protection did not correlate with the type of boost nor T-cell responses, but rather with the Nab titer prior to exposure...
  27. doi CD8+ NK cells are predominant in chimpanzees, characterized by high NCR expression and cytokine production, and preserved in chronic HIV-1 infection
    Erik Rutjens
    Biomedical Primate Research Centre, Rijswijk, The Netherlands
    Eur J Immunol 40:1440-50. 2010
    ..In contrast to HIV-1-infected humans, infected chimpanzees maintained their dominant CD8+ NK cell population, with high expression of natural cytotoxicity receptors...
  28. ncbi Protection from secondary human immunodeficiency virus type 1 infection in chimpanzees suggests the importance of antigenic boosting and a possible role for cytotoxic T cells
    S S Balla-Jhagjhoorsingh
    Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    J Infect Dis 184:136-43. 2001
    ..Data suggested that immunologic boosting by HIV-1 antigens or exposure to subinfectious doses of virus may be important events in sustaining sufficient immunity to prevent secondary infections from occurring...
  29. pmc Spontaneous and natural cytotoxicity receptor-mediated cytotoxicity are effector functions of distinct natural killer subsets in hepatitis C virus-infected chimpanzees
    B E Verstrepen
    Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    Clin Exp Immunol 185:42-9. 2016
    ..Our findings suggest that spontaneous and NCR-mediated cytotoxicity are effector functions of distinct NK subsets in HCV-infected chimpanzees. ..
  30. ncbi Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis
    G Koopman
    Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands
    Blood 84:1415-20. 1994
    ..Importantly, it precedes membrane damage that might lead to release from the cells of enzymes that are harmful to the surrounding tissues. Annexin V may prove important in further unravelling the regulation of apoptosis...
  31. ncbi Differential NKp30 inducibility in chimpanzee NK cells and conserved NK cell phenotype and function in long-term HIV-1-infected animals
    Erik Rutjens
    Biomedical Primate Research Centre, Rijswijk, The Netherlands
    J Immunol 178:1702-12. 2007
    ..These data suggest that one of the keys to successful lentivirus control may reside in part in a different regulation of NK cell-triggering receptor expression...
  32. ncbi Long-term persistence of HIV-1 vaccine-induced CD4+CD45RA-CD62L-CCR7- memory T-helper cells
    Sunita S Balla-Jhagjhoorsingh
    Department of Virology, Biomedical Primate Research Centre, 2280 GH Rijswijk, The Netherlands
    AIDS 18:837-48. 2004
    ..To determine in chimpanzees if candidate HIV-1 subunit protein vaccines were capable of eliciting long-lasting T-cell memory responses in the absence of viral infection, and to determine the specific characteristics of these responses...
  33. ncbi Lentivirus infections and mechanisms of disease resistance in chimpanzees
    Erik Rutjens
    Department of Virology, the Biomedical Primate Research Centre, Lange Kleiweg 139, 2288 GJ, Rijswijk, The Netherlands
    Front Biosci 8:d1134-45. 2003
    ..Here we review the history of HIV-1 infection in this species as well as the observations that have led to some of the current leading hypotheses regarding the resistance to AIDS in naturally infected African primates...
  34. ncbi Chronic hepatitis C virus infection established and maintained in chimpanzees independent of dendritic cell impairment
    Christine Rollier
    Department of Virology, Biomedical Primate Research Centre, 2280 GH Rijswijk, The Netherlands
    Hepatology 38:851-8. 2003
    ..Indeed, the maturation and allostimulatory impairment, as described in patient studies, are not necessary prerequisites but rather possible consequences of persistent and active HCV infection associated with disease progression...
  35. ncbi Molecular and functional characterization of NKG2D, NKp80, and NKG2C triggering NK cell receptors in rhesus and cynomolgus macaques: monitoring of NK cell function during simian HIV infection
    Roberto Biassoni
    Istituto Giannina Gaslini, Genova, Italy
    J Immunol 174:5695-705. 2005
    ....
  36. pmc Direct inoculation of simian immunodeficiency virus from sooty mangabeys in black mangabeys (Lophocebus aterrimus): first evidence of AIDS in a heterologous African species and different pathologic outcomes of experimental infection
    Cristian Apetrei
    Division of Microbiology and Immunology, Tulane National Primate Research Center, 18703 Three Rivers Rd, Covington, LA 70433, USA
    J Virol 78:11506-18. 2004
    ..Finally, this case of AIDS in an African monkey suggests that the dogma of SIV nonpathogenicity in African NHP hosts should be reconsidered...
  37. ncbi Human naive CD4 T-cell clones specific for HIV envelope persist for years in vivo in the absence of antigenic challenge
    Giuseppina Li Pira
    Laboratory of Clinical and Experimental Immunology, G Gaslini Institute, Genoa, Italy
    J Acquir Immune Defic Syndr 40:132-9. 2005
    ..An extended lifespan, homeostatic proliferation, or the ability of the thymus to issue the same CD4 T-cell clone reiteratively might account for the phenomenon...
  38. ncbi Helper function of cytolytic lymphocytes: switching roles in the immune response
    Giuseppina Li Pira
    Advanced Biotechnology Center, Genoa, Italy
    Eur J Immunol 37:66-77. 2007
    ..If this possibility is proven also in vivo, we should revise some of our views on the pathogenesis of diseases in which CD8 cells are key players, such as in viral infections, graft rejection and GVHD...
  39. pmc Aerosol immunization with NYVAC and MVA vectored vaccines is safe, simple, and immunogenic
    Max Corbett
    EuroVacc Foundation, Institut Swisse de Recherche Expérimentale sur la Cancer, CH 1066, Epalinges, Switzerland
    Proc Natl Acad Sci U S A 105:2046-51. 2008
    ..Thus, aerosol vaccination with NYVAC and MVA vectored vaccines constitutes a tool for large-scale vaccine efforts against mucosally transmitted pathogens...