Mervyn D I Vergouwen

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Plasminogen activator inhibitor-1 4G allele in the 4G/5G promoter polymorphism increases the occurrence of cerebral ischemia after aneurysmal subarachnoid hemorrhage
    M D I Vergouwen
    Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands
    Stroke 35:1280-3. 2004
  2. pmc Lower incidence of cerebral infarction correlates with improved functional outcome after aneurysmal subarachnoid hemorrhage
    Mervyn D I Vergouwen
    Department of Experimental Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Cereb Blood Flow Metab 31:1545-53. 2011
  3. pmc Magnesium sulfate for aneurysmal subarachnoid hemorrhage: the end of the road or more trials?
    Mervyn D I Vergouwen
    Department of Experimental Vascular Medicine, University of Amsterdam, Academic Medical Center, Meibergdreef 9, G1 145, 1105 AZ Amsterdam, The Netherlands
    Crit Care 15:140. 2011
  4. doi request reprint Subtherapeutic warfarin is not associated with increased hemorrhage rates in ischemic strokes treated with tissue plasminogen activator
    Mervyn D I Vergouwen
    University of Toronto, Toronto Western Hospital, Department of Medicine, Division of Neurology, 399 Bathurst Street, 5th Floor, West Wing, Room 443, Toronto, Ontario M5T 2S8, Canada
    Stroke 42:1041-5. 2011
  5. doi request reprint Definition of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage as an outcome event in clinical trials and observational studies: proposal of a multidisciplinary research group
    Mervyn D I Vergouwen
    Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands
    Stroke 41:2391-5. 2010
  6. doi request reprint Increased cortisol levels are associated with delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage
    Mervyn D I Vergouwen
    Department of Neurology, H2 234, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Neurocrit Care 12:342-5. 2010
  7. doi request reprint Reduced ADAMTS13 activity in delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage
    Mervyn D I Vergouwen
    Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Cereb Blood Flow Metab 29:1734-41. 2009
  8. doi request reprint Biologic effects of simvastatin in patients with aneurysmal subarachnoid hemorrhage: a double-blind, placebo-controlled randomized trial
    Mervyn D I Vergouwen
    Department of Neurology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands
    J Cereb Blood Flow Metab 29:1444-53. 2009
  9. ncbi request reprint Effect of nimodipine on outcome in patients with traumatic subarachnoid haemorrhage: a systematic review
    Mervyn D I Vergouwen
    Department of Neurology, Academic Medical Centre, Meibergdreef 9, Amsterdam, Netherlands
    Lancet Neurol 5:1029-32. 2006
  10. ncbi request reprint Dihydropyridine calcium antagonists increase fibrinolytic activity: a systematic review
    Mervyn D I Vergouwen
    Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Cereb Blood Flow Metab 27:1293-308. 2007

Detail Information

Publications31

  1. ncbi request reprint Plasminogen activator inhibitor-1 4G allele in the 4G/5G promoter polymorphism increases the occurrence of cerebral ischemia after aneurysmal subarachnoid hemorrhage
    M D I Vergouwen
    Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands
    Stroke 35:1280-3. 2004
    ..The aim of the present study was to investigate whether the PAI-1 4G/5G polymorphism is associated with the occurrence of cerebral ischemia, rebleeding, and other events, and clinical outcome after aneurysmal subarachnoid hemorrhage...
  2. pmc Lower incidence of cerebral infarction correlates with improved functional outcome after aneurysmal subarachnoid hemorrhage
    Mervyn D I Vergouwen
    Department of Experimental Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Cereb Blood Flow Metab 31:1545-53. 2011
    ....
  3. pmc Magnesium sulfate for aneurysmal subarachnoid hemorrhage: the end of the road or more trials?
    Mervyn D I Vergouwen
    Department of Experimental Vascular Medicine, University of Amsterdam, Academic Medical Center, Meibergdreef 9, G1 145, 1105 AZ Amsterdam, The Netherlands
    Crit Care 15:140. 2011
    ..The Magnesium in Aneurysmal Subarachnoid Hemorrhage-II (MASH-II: ISRCTN68742385) phase III clinical trial nears completion. It aims to include 1,200 patients, and its results are urgently awaited...
  4. doi request reprint Subtherapeutic warfarin is not associated with increased hemorrhage rates in ischemic strokes treated with tissue plasminogen activator
    Mervyn D I Vergouwen
    University of Toronto, Toronto Western Hospital, Department of Medicine, Division of Neurology, 399 Bathurst Street, 5th Floor, West Wing, Room 443, Toronto, Ontario M5T 2S8, Canada
    Stroke 42:1041-5. 2011
    ..7. However, evidence to date has been derived from a small single-center cohort of patients...
  5. doi request reprint Definition of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage as an outcome event in clinical trials and observational studies: proposal of a multidisciplinary research group
    Mervyn D I Vergouwen
    Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands
    Stroke 41:2391-5. 2010
    ..The second issue is the variability and overlap of terms used to describe each phenomenon. This makes comparisons among studies difficult...
  6. doi request reprint Increased cortisol levels are associated with delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage
    Mervyn D I Vergouwen
    Department of Neurology, H2 234, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Neurocrit Care 12:342-5. 2010
    ..Therefore, the purpose of the present study was to investigate whether increased serum cortisol levels after aneurysmal SAH are associated with DCI occurrence...
  7. doi request reprint Reduced ADAMTS13 activity in delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage
    Mervyn D I Vergouwen
    Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Cereb Blood Flow Metab 29:1734-41. 2009
    ..027, P=0.736). Our results suggest that microthrombosis has a role in the pathogenesis of DCI, as a result of decreased ADAMTS13 activity and endothelium dysfunction...
  8. doi request reprint Biologic effects of simvastatin in patients with aneurysmal subarachnoid hemorrhage: a double-blind, placebo-controlled randomized trial
    Mervyn D I Vergouwen
    Department of Neurology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands
    J Cereb Blood Flow Metab 29:1444-53. 2009
    ..We conclude that both the primary and secondary outcome results of this study do not support a beneficial effect of simvastatin in patients with SAH...
  9. ncbi request reprint Effect of nimodipine on outcome in patients with traumatic subarachnoid haemorrhage: a systematic review
    Mervyn D I Vergouwen
    Department of Neurology, Academic Medical Centre, Meibergdreef 9, Amsterdam, Netherlands
    Lancet Neurol 5:1029-32. 2006
    ..Here, we present data from all head-injury trials, including previously unpublished results from HIT 4...
  10. ncbi request reprint Dihydropyridine calcium antagonists increase fibrinolytic activity: a systematic review
    Mervyn D I Vergouwen
    Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Cereb Blood Flow Metab 27:1293-308. 2007
    ..In conclusions, calcium antagonists increase fibrinolytic activity. This may add to the beneficial pharmacological effect of calcium antagonists to prevent ischemic events in patients with hypertension and subarachnoid hemorrhage...
  11. doi request reprint Microthrombosis after aneurysmal subarachnoid hemorrhage: an additional explanation for delayed cerebral ischemia
    Mervyn D I Vergouwen
    Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Cereb Blood Flow Metab 28:1761-70. 2008
    ..Insight in the pathophysiology of DCI is crucial for the development of effective therapies against this complication. Because multiple pathways are involved, future research should focus on drugs with pleiotropic effects...
  12. doi request reprint Statin treatment and the occurrence of hemorrhagic stroke in patients with a history of cerebrovascular disease
    Mervyn D I Vergouwen
    Department of Neurology, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Stroke 39:497-502. 2008
    ..The purpose of this systematic review was therefore to investigate the effect of statin treatment on the occurrence of ischemic and hemorrhagic strokes in patients with a history of cerebrovascular disease...
  13. doi request reprint SAHIT Investigators--on the outcome of some subarachnoid hemorrhage clinical trials
    R Loch MacDonald
    St Michael s Hospital, University of Toronto, Toronto, ON, Canada
    Transl Stroke Res 4:286-96. 2013
    ..Key issues moving forward will be to use common definitions (common data elements), outcomes analysis, and to prioritize research questions, among others...
  14. doi request reprint Higher incidence of in-hospital complications in patients with clipped versus coiled ruptured intracranial aneurysms
    Mervyn D I Vergouwen
    Department of Medicine, Division of Neurology, University Health Network, University of Toronto, Toronto, Canada
    Stroke 42:3093-8. 2011
    ..It remains unknown if patients with clipped aneurysms also have a higher incidence of other in-hospital complications...
  15. doi request reprint Subarachnoid Hemorrhage International Trialists data repository (SAHIT)
    R Loch MacDonald
    St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    World Neurosurg 79:418-22. 2013
    ..We welcome collaboration with other investigators...
  16. doi request reprint Effect of statin treatment on vasospasm, delayed cerebral ischemia, and functional outcome in patients with aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis update
    Mervyn D I Vergouwen
    Division of Neurology, Toronto Western Hospital, 5th Floor West Wing, RM 425, 399 Bathurst St, Toronto, ON M5T2S8, Canada
    Stroke 41:e47-52. 2010
    ..Effect sizes were expressed in (pooled) risk ratio estimates. Data were pooled using random-effects models...
  17. doi request reprint The Subarachnoid Hemorrhage International Trialists (SAHIT) Repository: advancing clinical research in subarachnoid hemorrhage
    Blessing N R Jaja
    Division of Neurosurgery, Department of Surgery, St Michael s Hospital, Labatt Family Centre of Excellence in Brain Injury and Trauma Research, Keenan Research Centre of the Li Ka Shing Knowledge Institute of St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, ON, M5B 1W8, Canada
    Neurocrit Care 21:551-9. 2014
    ..We have compiled the largest known dataset of patients with SAH. The SAHIT repository may be an important resource for advancing clinical research in SAH and will benefit from contributions of additional datasets. ..
  18. doi request reprint Cerebral infarction after subarachnoid hemorrhage contributes to poor outcome by vasospasm-dependent and -independent effects
    Mervyn D I Vergouwen
    Department of Medicine, Division of Neurology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    Stroke 42:924-9. 2011
    ....
  19. doi request reprint Short-term outcomes after symptomatic internal carotid artery occlusion
    Matthew J Burke
    Toronto Western Hospital, 399 Bathurst Street, West Wing 5 448, Toronto, Ontario, M5T 2S8, Canada
    Stroke 42:2419-24. 2011
    ..Previous studies concerning internal carotid artery (ICA) occlusion have focused on long-term prognosis. The purpose of the present study was to evaluate short-term outcomes of patients with symptomatic ICA occlusion...
  20. pmc Effect of pharmaceutical treatment on vasospasm, delayed cerebral ischemia, and clinical outcome in patients with aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis
    Nima Etminan
    Division of Neurosurgery, St Michael s Hospital, Toronto, Ontario, Canada
    J Cereb Blood Flow Metab 31:1443-51. 2011
    ..This dissociation between vasospasm and clinical outcome could result from methodological problems, sample size, insensitivity of clinical outcome measures, or from mechanisms other than vasospasm that also contribute to poor outcome...
  21. doi request reprint Cerebral infarction in adults with bacterial meningitis
    Ewout S Schut
    Department of Neurology, Center of Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, PO Box 22660, 1100 Amsterdam, The Netherlands
    Neurocrit Care 16:421-7. 2012
    ..To evaluate clinical features and prognostic factors of cerebral infarctions in adults with community-acquired bacterial meningitis...
  22. doi request reprint Eccentric narrowing and enhancement of symptomatic middle cerebral artery stenoses in patients with recent ischemic stroke
    Mervyn D I Vergouwen
    Division of Neurology, Department of Medicine, Toronto Western Hospital, and University of Toronto, 2075 Bayview Ave, Room A442, Toronto, ON M4N 3M5, Canada
    Arch Neurol 68:338-42. 2011
    ..To characterize the vessel wall imaging findings and enhancement patterns in the middle cerebral artery of patients with presumed atherosclerotic disease and recent infarction in the territory of the affected artery...
  23. ncbi request reprint [Limited benefit of diagnostic second opinions in a neurology department]
    Luuk Wieske
    Academisch Medisch Centrum, Amsterdam, afd Neurologie, The Netherlands
    Ned Tijdschr Geneeskd 155:A3542. 2011
    ..To describe the short and long term results of neurological second opinions with regard to medical aspects and patient satisfaction...
  24. doi request reprint Clinical prediction models for aneurysmal subarachnoid hemorrhage: a systematic review
    Blessing N R Jaja
    St Michael s Hospital, University of Toronto, Toronto, ON, Canada
    Neurocrit Care 18:143-53. 2013
    ..We evaluated the methodological validity of SAH prediction models and the relevance of the main predictors to identify potentially reliable models and to guide future attempts at model development...
  25. doi request reprint Diffuse cerebral intravascular coagulation and cerebral infarction in pneumococcal meningitis
    Mervyn D I Vergouwen
    Department of Neurology, H2 259, Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam, 1105 AZ, The Netherlands
    Neurocrit Care 13:217-27. 2010
    ..We hypothesized that diffuse cerebral intravascular coagulation is an additional explanation of cerebral infarction in patients with pneumococcal meningitis...
  26. doi request reprint Prevalence and characterization of ECG abnormalities after intracerebral hemorrhage
    Maurits D R van Bree
    Department of Neurology, Academic Medical Centre Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Neurocrit Care 12:50-5. 2010
    ..The purpose of this study is to investigate the prevalence and type of ECG abnormalities in a consecutive series of ICH patients, and their possible association with pre-defined neurological and radiological parameters...
  27. doi request reprint Vasospasm versus delayed cerebral ischemia as an outcome event in clinical trials and observational studies
    Mervyn D I Vergouwen
    Utrecht Stroke Center, Department of Neurology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    Neurocrit Care 15:308-11. 2011
    ..Cerebral infarction was supported as the most appropriate definition for delayed cerebral ischemia in the context of clinical trials...
  28. doi request reprint Venous thromboembolism prophylaxis and treatment in patients with acute stroke and traumatic brain injury
    Mervyn D I Vergouwen
    Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Curr Opin Crit Care 14:149-55. 2008
    ..This review analyzes the available literature to propose guidelines for the prevention and treatment of venous thromboembolism in these groups of patients...
  29. doi request reprint PHASES Score for Prediction of Intracranial Aneurysm Growth
    Daan Bäckes
    From the Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus D B, M D I V, A T T G, A S E B, A A, G J E R, Department of Radiology B K V, and Julius Center for Health Sciences and Primary Care J P G, A A, University Medical Center Utrecht, Utrecht, the Netherlands Departments of Neurology M J H W and Radiology M A A v W, Leiden University Medical Center, Leiden, the Netherlands and Division of Neuroradiology, Department of Medical Imaging, Toronto Western Hospital, Toronto, Canada K G t B, R A
    Stroke 46:1221-6. 2015
    ..We investigated whether PHASES, a score providing absolute risks of aneurysm rupture based on 6 easily retrievable risk factors, also predicts aneurysm growth...
  30. ncbi request reprint [Limited benefit of diagnostic second opinions in a neurology department]
    Luuk Wieske
    Academisch Medisch Centrum, Amsterdam, afd Neurologie, The Netherlands
    Ned Tijdschr Geneeskd 155:A3542. 2011
    ..To describe the short and long term results of neurological second opinions with regard to medical aspects and patient satisfaction...
  31. doi request reprint Safety and functional outcome of thrombolysis in dissection-related ischemic stroke: a meta-analysis of individual patient data
    Sanne M Zinkstok
    Department of Neurology, H2 216, Academic Medical Center, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    Stroke 42:2515-20. 2011
    ..The safety and efficacy of thrombolysis in cervical artery dissection (CAD) are controversial. The aim of this meta-analysis was to pool all individual patient data and provide a valid estimate of safety and outcome of thrombolysis in CAD...