Niels van Royen

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. ncbi Exogenous application of transforming growth factor beta 1 stimulates arteriogenesis in the peripheral circulation
    Niels van Royen
    Max Planck Institute for Physiological and Clinical Research, Department of Experimental Cardiology, Bad Nauheim, Germany
    FASEB J 16:432-4. 2002
  2. doi A critical review of clinical arteriogenesis research
    Niels van Royen
    Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Am Coll Cardiol 55:17-25. 2009
  3. ncbi START Trial: a pilot study on STimulation of ARTeriogenesis using subcutaneous application of granulocyte-macrophage colony-stimulating factor as a new treatment for peripheral vascular disease
    Niels van Royen
    Department of Cardiology, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Circulation 112:1040-6. 2005
  4. ncbi Local monocyte chemoattractant protein-1 therapy increases collateral artery formation in apolipoprotein E-deficient mice but induces systemic monocytic CD11b expression, neointimal formation, and plaque progression
    N van Royen
    Department of Cardiology, University of Amsterdam, Amsterdam, The Netherlands
    Circ Res 92:218-25. 2003
  5. ncbi Design of the START-trial: STimulation of ARTeriogenesis using subcutaneous application of GM-CSF as a new treatment for peripheral vascular disease. A randomized, double-blind, placebo-controlled trial
    Niels van Royen
    Department of Cardiology, University of Amsterdam, The Netherlands
    Vasc Med 8:191-6. 2003
  6. ncbi CD44 regulates arteriogenesis in mice and is differentially expressed in patients with poor and good collateralization
    N van Royen
    Department of Cardiology, Room B2 114, Academic Medical Center, University of Amsterdam, Meibergdreef 9 1105 AZ, Amsterdam, The Netherlands
    Circulation 109:1647-52. 2004
  7. pmc Expression of a retinoic acid signature in circulating CD34 cells from coronary artery disease patients
    Tineke C T M van der Pouw Kraan
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Van der Boechorststraat, 1081BT Amsterdam, The Netherlands
    BMC Genomics 11:388. 2010
  8. ncbi Abnormal monocyte recruitment and collateral artery formation in monocyte chemoattractant protein-1 deficient mice
    Michiel Voskuil
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Vasc Med 9:287-92. 2004
  9. ncbi Leukocyte subpopulations and arteriogenesis: specific role of monocytes, lymphocytes and granulocytes
    Imo E Hoefer
    Research Group for Experimental and Clinical Arteriogenesis, Department of Cardiology, University of Freiburg, Germany
    Atherosclerosis 181:285-93. 2005
  10. ncbi Modulation of collateral artery growth in a porcine hindlimb ligation model using MCP-1
    Michiel Voskuil
    Department of Cardiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 284:H1422-8. 2003

Collaborators

Detail Information

Publications43

  1. ncbi Exogenous application of transforming growth factor beta 1 stimulates arteriogenesis in the peripheral circulation
    Niels van Royen
    Max Planck Institute for Physiological and Clinical Research, Department of Experimental Cardiology, Bad Nauheim, Germany
    FASEB J 16:432-4. 2002
    ..10.11 +/- 0.04 x 10(5), P<0.05). TGF-beta1 had no direct pro-angiogenic effect on human umbilical vein endothelial cells in a spheroid model of angiogenesis and inhibited the angiogenic effects of vascular endothelial growth factor...
  2. doi A critical review of clinical arteriogenesis research
    Niels van Royen
    Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Am Coll Cardiol 55:17-25. 2009
    ..In a reversed bedside-to-bench approach, the characterization of ribonucleic acid and protein expression patterns in these patients generated new targets for therapeutic arteriogenesis...
  3. ncbi START Trial: a pilot study on STimulation of ARTeriogenesis using subcutaneous application of granulocyte-macrophage colony-stimulating factor as a new treatment for peripheral vascular disease
    Niels van Royen
    Department of Cardiology, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Circulation 112:1040-6. 2005
    ..Experimental models showed beneficial effects of GM-CSF on collateral artery growth in the peripheral circulation. Thus, in the present study, we evaluated the effects of GM-CSF in patients with peripheral artery disease...
  4. ncbi Local monocyte chemoattractant protein-1 therapy increases collateral artery formation in apolipoprotein E-deficient mice but induces systemic monocytic CD11b expression, neointimal formation, and plaque progression
    N van Royen
    Department of Cardiology, University of Amsterdam, Amsterdam, The Netherlands
    Circ Res 92:218-25. 2003
    ..However, the local treatment did not preclude systemic effects on atherogenesis, leading to increased atherosclerotic plaque formation and changes in cellular content of plaques...
  5. ncbi Design of the START-trial: STimulation of ARTeriogenesis using subcutaneous application of GM-CSF as a new treatment for peripheral vascular disease. A randomized, double-blind, placebo-controlled trial
    Niels van Royen
    Department of Cardiology, University of Amsterdam, The Netherlands
    Vasc Med 8:191-6. 2003
    ..Iliac flow reserve and conductance will be measured by magnetic resonance imaging...
  6. ncbi CD44 regulates arteriogenesis in mice and is differentially expressed in patients with poor and good collateralization
    N van Royen
    Department of Cardiology, Room B2 114, Academic Medical Center, University of Amsterdam, Meibergdreef 9 1105 AZ, Amsterdam, The Netherlands
    Circulation 109:1647-52. 2004
    ..CD44 glycoproteins are involved in leukocyte extravasation but also in the regulation of growth factor activation, stability, and signaling. Here, we explored the role of CD44 during arteriogenesis...
  7. pmc Expression of a retinoic acid signature in circulating CD34 cells from coronary artery disease patients
    Tineke C T M van der Pouw Kraan
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Van der Boechorststraat, 1081BT Amsterdam, The Netherlands
    BMC Genomics 11:388. 2010
    ..Knowledge is still scarce about the transcriptional programs used by CD34+ cells from peripheral blood, and how these are affected in coronary artery disease (CAD) patients...
  8. ncbi Abnormal monocyte recruitment and collateral artery formation in monocyte chemoattractant protein-1 deficient mice
    Michiel Voskuil
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Vasc Med 9:287-92. 2004
    ....
  9. ncbi Leukocyte subpopulations and arteriogenesis: specific role of monocytes, lymphocytes and granulocytes
    Imo E Hoefer
    Research Group for Experimental and Clinical Arteriogenesis, Department of Cardiology, University of Freiburg, Germany
    Atherosclerosis 181:285-93. 2005
    ..The role of these two cell types in arteriogenesis remains yet to be clarified, which was the aim of the current study...
  10. ncbi Modulation of collateral artery growth in a porcine hindlimb ligation model using MCP-1
    Michiel Voskuil
    Department of Cardiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 284:H1422-8. 2003
    ..05). Modulation of the process of arteriogenesis is feasible in this large animal model via intra-arterial infusion of the Cys-Cys-chemokine MCP-1...
  11. doi Suppression of inflammatory signaling in monocytes from patients with coronary artery disease
    Stephan H Schirmer
    Department of Cardiology, Academic Medical Center, University of Amsterdam, 1105AZ Amsterdam, The Netherlands
    J Mol Cell Cardiol 46:177-85. 2009
    ..Transcriptome differences of circulating cells possibly play less of a role than hitherto thought in the individual patient's susceptibility to atherosclerotic CAD, when appropriately matched for clinical symptoms and medication taken...
  12. pmc Blocking interferon {beta} stimulates vascular smooth muscle cell proliferation and arteriogenesis
    Stephan H Schirmer
    Department of Cardiology, Saarland University Hospital, 66421 Homburg Saar, Germany
    J Biol Chem 285:34677-85. 2010
    ..Inhibition of IFNβ stimulates VSMC proliferation and collateral artery growth...
  13. ncbi Aspirin, but not clopidogrel, reduces collateral conductance in a rabbit model of femoral artery occlusion
    Imo E Hoefer
    Research Group for Arteriogenesis, Department of Cardiology, University of Freiburg, Freiburg, Germany
    J Am Coll Cardiol 46:994-1001. 2005
    ..The objective of this study was to test the potential of aspirin and clopidogrel to influence collateral artery growth (arteriogenesis)...
  14. doi Impact of anatomical and functional severity of coronary atherosclerotic plaques on the transmural perfusion gradient: a [15O]H2O PET study
    Ibrahim Danad
    Department of Cardiology, VU University Medical Center, Amsterdam, De Boelelaan 1117, 1081 HV, The Netherlands
    Eur Heart J 35:2094-105. 2014
    ....
  15. doi Galectin-2 expression is dependent on the rs7291467 polymorphism and acts as an inhibitor of arteriogenesis
    Anja M van der Laan
    Department of Cardiology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Eur Heart J 33:1076-84. 2012
    ..Knowledge on factors involved in human arteriogenesis is scarce. Thus, the aim of the present study is to identify targets in monocytes that are critical for arteriogenesis in patients with CAD...
  16. pmc Endothelial glycocalyx dimensions are reduced in growing collateral arteries and modulate leucocyte adhesion in arteriogenesis
    Sebastian Grundmann
    Department of Cardiology, AMC, University of Amsterdam, The Netherlands
    J Cell Mol Med 13:3463-74. 2009
    ..5 +/- 3.5;..
  17. doi Local cytokine concentrations and oxygen pressure are related to maturation of the collateral circulation in humans
    Stephan H Schirmer
    Department of Cardiology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Am Coll Cardiol 53:2141-7. 2009
    ..Our aim was to determine cytokine and oxygen gradients over the collateral circulation in humans...
  18. doi Interferon-beta signaling is enhanced in patients with insufficient coronary collateral artery development and inhibits arteriogenesis in mice
    Stephan H Schirmer
    Department of Cardiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands
    Circ Res 102:1286-94. 2008
    ..Inhibition of IFN-beta signaling may serve as a novel approach for the stimulation of collateral artery growth...
  19. ncbi A new intra-arterial delivery platform for pro-arteriogenic compounds to stimulate collateral artery growth via transforming growth factor-beta1 release
    Sebastian Grundmann
    Department of Cardiology, AMC, University of Amsterdam, Amsterdam, The Netherlands
    J Am Coll Cardiol 50:351-8. 2007
    ..The purpose of this study was to develop a cytokine-eluting stent to stimulate collateral artery growth (arteriogenesis) in the peripheral circulation of the rabbit via local transforming growth factor (TGF)-beta1 release...
  20. doi Changes in Coronary Blood Flow After Acute Myocardial Infarction: Insights From a Patient Study and an Experimental Porcine Model
    Guus A de Waard
    Department of Cardiology, ICaR VU, VU University Medical Center, Amsterdam, The Netherlands
    JACC Cardiovasc Interv 9:602-13. 2016
    ..The aim of this study was to determine the effects of an acute myocardial infarction (AMI) on baseline and hyperemic flow in both culprit and nonculprit arteries...
  21. ncbi Direct evidence for tumor necrosis factor-alpha signaling in arteriogenesis
    Imo E Hoefer
    Department of Cardiology, University of Freiburg, Germany
    Circulation 105:1639-41. 2002
    ..We hypothesized that arteriogenesis is reduced in mice lacking functional TNF-alpha or p55 receptor. To test this hypothesis, we developed a novel microsphere-based murine model of hindlimb perfusion measurement...
  22. doi Acute haemodynamic effects of accelerated idioventricular rhythm in primary percutaneous coronary intervention
    Ronak Delewi
    Department of Cardiology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    EuroIntervention 7:467-71. 2011
    ..Accelerated idioventricular rhythm (AIVR) is very frequently observed in primary percutaneous coronary intervention (PCI), however knowledge of the haemodynamic effects is lacking...
  23. doi Kinetics of coagulation in ST-elevation myocardial infarction following successful primary percutaneous coronary intervention
    Paul F A Teunissen
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    Thromb Res 137:64-71. 2016
    ..We aimed to investigate kinetics of important coagulation markers in percutaneous coronary intervention (PCI)-treated STEMI patients...
  24. doi Coronary vasomotor function in infarcted and remote myocardium after primary percutaneous coronary intervention
    Paul F A Teunissen
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    Heart 101:1577-83. 2015
    ..The aim was to investigate the temporal evolution of coronary vasodilatory reserve in patients with AMI by use of [(15)O]H2O positron emission tomography, after successful percutaneous coronary intervention...
  25. doi Invasive measurement of coronary microvascular resistance in patients with acute myocardial infarction treated by primary PCI
    Raquel P Amier
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    Heart 100:13-20. 2014
    ....
  26. ncbi Differential expression of GAPDH and beta3-actin in growing collateral arteries
    Elisabeth Deindl
    Max Planck Institute, Department of Experimental Cardiology, Bad Nauheim, Germany
    Mol Cell Biochem 236:139-46. 2002
    ..From these results we conclude that the 18S rRNA, but not the GAPDH- or beta-actin mRNA is an appropriate internal control for relative quantitation of gene expression under conditions of cell proliferation in growing vessels...
  27. ncbi Experimental models of arteriogenesis: differences and implications
    Imo E Hoefer
    Department of Experimental Cardiology, UMC, University of Utrecht, The Netherlands
    Lab Anim (NY) 35:36-44. 2006
    ....
  28. pmc Circulating MicroRNAs Characterizing Patients with Insufficient Coronary Collateral Artery Function
    Nazanin Hakimzadeh
    Department of Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 10:e0137035. 2015
    ..We sought to identify miRNAs that are differentially expressed in chronic total occlusion (CTO) patients with well or poorly developed collateral arteries...
  29. doi Forkhead box protein P1 as a downstream target of transforming growth factor-β induces collagen synthesis and correlates with a more stable plaque phenotype
    Pieter T Bot
    Department of Cardiology, AMC Amsterdam, The Netherlands
    Atherosclerosis 218:33-43. 2011
    ..We studied FoxP1 expression in atherosclerotic tissue, correlated FoxP1 expression with plaque characteristics and identified associations between FoxP1 and plaque proteins...
  30. doi Prevalence and impact of a chronic total occlusion in a non-infarct-related artery on long-term mortality in diabetic patients with ST elevation myocardial infarction
    Bimmer E P M Claessen
    Department of Cardiology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Heart 96:1968-72. 2010
    ..The prevalence of CTO in a non-IRA was studied and its impact on long-term mortality in STEMI patients with DM was investigated...
  31. doi Fluoroscopy Assisted Scoring of Myocardial Hypoperfusion (FLASH) ratio as a novel predictor of mortality after primary PCI in STEMI patients
    P Stefan Biesbroek
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands Interuniversity Cardiology Institute of the Netherlands ICIN, Utrecht, The Netherlands
    Int J Cardiol 202:639-45. 2016
    ....
  32. doi The coronary collateral circulation: genetic and environmental determinants in experimental models and humans
    Paul F A Teunissen
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    J Mol Cell Cardiol 52:897-904. 2012
    ..The present review focuses on this heterogeneity of genetic as well as non-genetic determinants of the coronary collateral circulation. This article is part of a Special Issue entitled "Coronary Blood Flow"...
  33. doi Targeting angiogenesis to restore the microcirculation after reperfused MI
    Anja M van der Laan
    Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Nat Rev Cardiol 6:515-23. 2009
    ....
  34. ncbi Therapeutic manipulation of the collateral circulation--future directions
    Niels van Royen
    Department of Cardiology, University of Amsterdam, Amsterdam, The Netherlands
    Coron Artery Dis 15:399-403. 2004
    ..Future studies in this field will have to cope with problems of substance choice, clinical detection methods and unwanted side-effects...
  35. doi Interferon-Beta, a Decisive Factor in Angiogenesis and Arteriogenesis
    Cansu Yildirim
    1 Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    J Interferon Cytokine Res 35:411-20. 2015
    ....
  36. doi Evaluating the optimal timing of revascularisation in patients with transient ST-segment elevation myocardial infarction: rationale and design of the TRANSIENT Trial
    Jorrit Lemkes
    Department of Cardiology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    J Cardiovasc Transl Res 7:590-6. 2014
    ..The TRANSIENT Trial evaluates whether a delayed invasive strategy (according to NSTEMI-guidelines) is superior to an immediate invasive strategy (according to STEMI-guidelines) in patients with a transient STEMI. ..
  37. pmc Additional value of transluminal attenuation gradient in CT angiography to predict hemodynamic significance of coronary artery stenosis
    Wynand J Stuijfzand
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    JACC Cardiovasc Imaging 7:374-86. 2014
    ....
  38. doi Magnetic resonance imaging-defined areas of microvascular obstruction after acute myocardial infarction represent microvascular destruction and haemorrhage
    Lourens F H J Robbers
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    Eur Heart J 34:2346-53. 2013
    ..However, the exact histopathological correlate of the contrast-devoid core and its relation to IMH is unknown...
  39. pmc Galectin-2 induces a proinflammatory, anti-arteriogenic phenotype in monocytes and macrophages
    Cansu Yildirim
    Dept of Molecular Cell Biology and Immunology, VU University Medical Centre, Amsterdam, The Netherlands
    PLoS ONE 10:e0124347. 2015
    ..Interference with CD14-Galectin-2 interaction may provide a new intervention strategy to stimulate growth of collateral arteries in genetically compromised cardiovascular patients. ..
  40. pmc Cellular and pharmacological targets to induce coronary arteriogenesis
    Maurits R Hollander
    VU University Medical Center, Department of Cardiology, Room 4D 36, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Curr Cardiol Rev 10:29-37. 2014
    ..Further research to the exact mechanisms is needed in order to develop a pharmalogical stimulant. This review gives an overview of recent data in the field of arteriogenesis. ..
  41. doi Effect of cardiac hybrid ¹⁵O-water PET/CT imaging on downstream referral for invasive coronary angiography and revascularization rate
    Ibrahim Danad
    Department of Cardiology, VU University Medical Center, De Boelelaan 1117, Amsterdam 1081 HV, The Netherlands
    Eur Heart J Cardiovasc Imaging 15:170-9. 2014
    ..This study evaluates the impact of hybrid imaging on referral for invasive coronary angiography (ICA) and revascularization rates...
  42. doi MAb therapy against the IFN-α/β receptor subunit 1 stimulates arteriogenesis in a murine hindlimb ischaemia model without enhancing atherosclerotic burden
    Paul F A Teunissen
    Department of Cardiology, VU University Medical Center, De Boelelaan 1117, 1081HV Amsterdam, The Netherlands
    Cardiovasc Res 107:255-66. 2015
    ..We therefore hypothesized that mAb therapy to inhibit IFNβ signalling would stimulate arteriogenesis and simultaneously attenuate-rather than aggravate-atherosclerosis...
  43. pmc Effect of additional treatment with EXenatide in patients with an Acute Myocardial Infarction (EXAMI): study protocol for a randomized controlled trial
    Martijn Scholte
    Department of Cardiology, VU University Medical Center, De Boelelaan 11171081 HV Amsterdam, The Netherlands
    Trials 12:240. 2011
    ....