Tim J Schuijt

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. doi request reprint The intestinal microbiota and host immune interactions in the critically ill
    Tim J Schuijt
    Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam, 1105 AZ, The Netherlands
    Trends Microbiol 21:221-9. 2013
  2. pmc Identification and characterization of Ixodes scapularis antigens that elicit tick immunity using yeast surface display
    Tim J Schuijt
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 6:e15926. 2011
  3. pmc A tick mannose-binding lectin inhibitor interferes with the vertebrate complement cascade to enhance transmission of the lyme disease agent
    Tim J Schuijt
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06420, USA
    Cell Host Microbe 10:136-46. 2011
  4. pmc Factor Xa activation of factor V is of paramount importance in initiating the coagulation system: lessons from a tick salivary protein
    Tim J Schuijt
    Center for Experimental and Molecular Medicine, University of Amsterdam, Meibergdreef 9, Room L01 145, 1105 AZ, Amsterdam, The Netherlands
    Circulation 128:254-66. 2013
  5. doi request reprint An Ixodes ricinus Tick Salivary Lectin Pathway Inhibitor Protects Borrelia burgdorferi sensu lato from Human Complement
    Alex Wagemakers
    1 Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Vector Borne Zoonotic Dis 16:223-8. 2016
  6. pmc A tick gut protein with fibronectin III domains aids Borrelia burgdorferi congregation to the gut during transmission
    Sukanya Narasimhan
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS Pathog 10:e1004278. 2014
  7. doi request reprint Complement evasion by Borrelia burgdorferi: it takes three to tango
    Steven W de Taeye
    Center for Experimental and Molecular Medicine, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Trends Parasitol 29:119-28. 2013
  8. pmc The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia
    Tim J Schuijt
    Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands Department of Medicine, Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Department of Clinical Chemistry, Hematology and Immunology, Diakonessenhuis Utrecht, The Netherlands
    Gut 65:575-83. 2016

Collaborators

Detail Information

Publications8

  1. doi request reprint The intestinal microbiota and host immune interactions in the critically ill
    Tim J Schuijt
    Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam, 1105 AZ, The Netherlands
    Trends Microbiol 21:221-9. 2013
    ..In this review, we highlight these aspects and focus on recent key findings addressing the role of intestinal microbiota in antimicrobial defense mechanisms and its impact on intestinal homeostasis in the critically ill...
  2. pmc Identification and characterization of Ixodes scapularis antigens that elicit tick immunity using yeast surface display
    Tim J Schuijt
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 6:e15926. 2011
    ..These studies also suggest that these antigens may serve as potential vaccine candidates to thwart tick feeding...
  3. pmc A tick mannose-binding lectin inhibitor interferes with the vertebrate complement cascade to enhance transmission of the lyme disease agent
    Tim J Schuijt
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06420, USA
    Cell Host Microbe 10:136-46. 2011
    ....
  4. pmc Factor Xa activation of factor V is of paramount importance in initiating the coagulation system: lessons from a tick salivary protein
    Tim J Schuijt
    Center for Experimental and Molecular Medicine, University of Amsterdam, Meibergdreef 9, Room L01 145, 1105 AZ, Amsterdam, The Netherlands
    Circulation 128:254-66. 2013
    ..The current paradigm assumes that FV activation is initiated by limited proteolysis by traces of (meizo) thrombin...
  5. doi request reprint An Ixodes ricinus Tick Salivary Lectin Pathway Inhibitor Protects Borrelia burgdorferi sensu lato from Human Complement
    Alex Wagemakers
    1 Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Vector Borne Zoonotic Dis 16:223-8. 2016
    ..burgdorferi sensu lato (s.l.) strains, we aimed to identify, describe, and characterize the I. ricinus ortholog of TSLPI...
  6. pmc A tick gut protein with fibronectin III domains aids Borrelia burgdorferi congregation to the gut during transmission
    Sukanya Narasimhan
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS Pathog 10:e1004278. 2014
    ..Our observations suggest that the interaction between Borrelia and Ixofin3D facilitates spirochete congregation to the gut during transmission, and provides a "molecular exit" direction for spirochete egress from the gut. ..
  7. doi request reprint Complement evasion by Borrelia burgdorferi: it takes three to tango
    Steven W de Taeye
    Center for Experimental and Molecular Medicine, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Trends Parasitol 29:119-28. 2013
    ..These interactions with complement can be host species-specific. This review provides an overview of interactions between Borrelia, tick, and host leading to evasion of complement-mediated killing...
  8. pmc The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia
    Tim J Schuijt
    Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands Department of Medicine, Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Department of Clinical Chemistry, Hematology and Immunology, Diakonessenhuis Utrecht, The Netherlands
    Gut 65:575-83. 2016
    ..The precise role of the gut microbiota in bacterial pneumonia, however, is unknown. Here, we investigate the function of the gut microbiota in the host defence against Streptococcus pneumoniae infections...