Henriette J Scherpbier
Affiliation: Academic Medical Center
Country: The Netherlands
- Liver failure in a child receiving highly active antiretroviral therapy and voriconazoleHenriette J Scherpbier
Emma Children s Hospital, Academic Medical Centre, Amsterdam, The Netherlands
Clin Infect Dis 37:828-30. 2003..We describe a 10-year-old child with vertically transmitted acquired immunodeficiency syndrome who was receiving antiretroviral combination therapy and died of liver failure after beginning voriconazole therapy...
- Long-term experience with combination antiretroviral therapy that contains nelfinavir for up to 7 years in a pediatric cohortHenriette J Scherpbier
Emma Children s Hospital, Academic Medical Center, Amsterdam, The Netherlands
Pediatrics 117:e528-36. 2006..We sought to provide long-term data on the clinical, immunologic, and virologic response to highly active antiretroviral therapy in infants and children who are naive to protease inhibitors...
- Once-daily highly active antiretroviral therapy for HIV-infected children: safety and efficacy of an efavirenz-containing regimenHenriette J Scherpbier
Emma Children s Hospital, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Pediatrics 119:e705-15. 2007....
- A pharmacokinetic and pharmacogenetic study of efavirenz in children: dosing guidelines can result in subtherapeutic concentrationsRob ter Heine
Department of Pharmacy and Pharmacology, Slotervaart Hospital, Amsterdam, The Netherlands
Antivir Ther 13:779-87. 2008..Our main objectives were to study the population pharmacokinetics of efavirenz and to explore the adequacy of dosing guidelines...
- Cytomegalovirus rather than HIV triggers the outgrowth of effector CD8+CD45RA+CD27- T cells in HIV-1-infected childrenVincent Bekker
Emma Children s Hospital, Sanquin Research and Landsteiner Laboratory, Academic Medical Center fInternational Antiviral Therapy Evaluation Center, Amsterdam, The Netherlands
AIDS 19:1025-34. 2005..To analyse the effect of viral coinfections on immune reconstitution in HIV-1-infected children (< 18 years) taking highly active antiretroviral therapy (HAART)...
- Population pharmacokinetics and pharmacodynamics of nelfinavir and its active metabolite M8 in HIV-1-infected childrenKristel M L Crommentuyn
Department of Pharmacy and Pharmacology, Slotervaart Hospital, Amsterdam, The Netherlands
Pediatr Infect Dis J 25:538-43. 2006....
- Neurologic abnormalities in HIV-1 infected children in the era of combination antiretroviral therapyLotus A van Arnhem
Department of Pediatric Hematology, Immunology and Infectious Diseases, Emma Children s Hospital, Academic Medical Centre AMC, Amsterdam, The Netherlands
PLoS ONE 8:e64398. 2013..In recent years, the neurological outcome of HIV-1 infected children has substantially improved with combination antiretroviral therapy (cART). However, data regarding the long-term effect of cART and neurologic outcome are limited...
- Viral dynamics after starting first-line HAART in HIV-1-infected childrenVincent Bekker
Emma Children s Hospital, Academic Medical Center, The Netherlands
AIDS 20:517-23. 2006..Therefore viral decay and time to reach a pVL of < 400 copies/ml during the first weeks after starting HAART were studied in a cohort of HIV-1-infected children...
- Long-Term Changes of Subcutaneous Fat Mass in HIV-Infected Children on Antiretroviral Therapy: A Retrospective Analysis of Longitudinal Data from Two Pediatric HIV-CohortsSophie Cohen
Department of Paediatric Haematology, Immunology, and Infectious Diseases, Emma Children s Hospital, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
PLoS ONE 10:e0120927. 2015....
- A neonate with macrosomia, cardiomyopathy and hepatomegaly born to an HIV-infected motherMieke H Godfried
Department of Internal Medicine, AMC, Amsterdam, The Netherlands
Eur J Pediatr 164:190-2. 2005
- The pharmacokinetics of nelfinavir in HIV-1-infected childrenRolf P G van Heeswijk
Dept of Pharmacy and Pharmacology, Slotervaart Hospital, Amsterdam, The Netherlands
Ther Drug Monit 24:487-91. 2002..However, due to a large interpatient variability in the exposure, individual dosage adjustments based on plasma concentrations may be necessary for both dosing regimens to ensure optimal treatment...
- Haematological parameters of HIV-1-uninfected infants born to HIV-1-infected mothersMadeleine J Bunders
Department of Paediatric Haematology, Immunology and Infectious Diseases, Emma Children s Hospital, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
Acta Paediatr 94:1571-7. 2005..To investigate haematological parameters in infants born to HIV-1-infected mothers and exposed to combination antiretroviral therapy (ART) used to prevent mother-to-child transmission (MTCT)...
- Cerebral injury in perinatally HIV-infected children compared to matched healthy controlsSophie Cohen
From the Department of Pediatric Hematology, Immunology and Infectious Diseases S C, H J S, T W K, D P, Emma Children s Hospital AMC, Amsterdam the Department of Radiology M W A C, H J M, C B L M M, the Department of Global Health and Amsterdam Institute of Global Health and Development P R, and the Department of Internal Medicine, Division of Infectious Diseases, Center for Infection and Immunity Amsterdam CINIMA P R, Academic Medical Centre, University of Amsterdam and HIV Monitoring Foundation P R, Amsterdam, The Netherlands
Neurology 86:19-27. 2016..The current study aims to evaluate the neurologic state of perinatally HIV-infected children on combination antiretroviral therapy and to attain a better insight into the pathogenesis of their persistent neurologic and cognitive deficits...
- Establishment of the CD4+ T-cell pool in healthy children and untreated children infected with HIV-1Mette D Hazenberg
Department of Clinical Viro Immunology, Sanquin Research at CLB, Amsterdam, The Netherlands
Blood 104:3513-9. 2004..We postulate that in children infected with HIV, similar to adults infected with HIV, continuous activation of naive T cells leads to erosion of the naive T-cell pool and may be a major factor in lowering CD4(+) T-cell numbers...
- Health-related quality of life in perinatally HIV-infected children in the NetherlandsSophie Cohen
a Department of Paediatric Hematology, Immunology, and Infectious Diseases, Emma Children s Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
AIDS Care 27:1279-88. 2015..However, the HIV-infected group did contain more children with HRQoL impairment, suggesting that HIV-infected children in the Netherlands are still more vulnerable to a compromised HRQoL. ..
- Neurometabolite Alterations Associated With Cognitive Performance in Perinatally HIV-Infected ChildrenYvonne W Van Dalen
From the Department of Pediatric Hematology, Immunology and Infectious Diseases, YWVD, CB, SC, JATS, HJS, TWK, DP Psychosocial Department JATS, Emma Children s Hospital Academic Medical Center Neurochemistry Laboratory and Biobank CET, Department of Clinical Chemistry, VU University Medical Center and Neurocampus Amsterdam, the Netherlands Neurology JK, Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, Basel, Switzerland Department of Experimental Immunology NAK Department of Global Health and Amsterdam Institute of Global Health and Development PR, Academic Medical Center HIV Monitoring Foundation PR Department of Internal Medicine PR, Division of Infectious Diseases, Center for Infection and Immunity Amsterdam CINIMA and Department of Radiology CBLMM, MWAC, Academic Medical Center, Amsterdam, The Netherlands
Medicine (Baltimore) 95:e3093. 2016..Levels of several neurometabolites were associated with cognitive performance, suggesting that MRS may be a useful method to assess cerebral changes potentially linked to cognitive outcomes. ..
- Mannose-binding lectin and the risk of HIV transmission and disease progression in children: a systematic reviewJoël Israëls
Department of Pediatric Immunology, Hematology and Infectiology, Emma Children s Hospital, Academic Medical Centre, H7 228, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Pediatr Infect Dis J 31:1272-8. 2012..It is unclear whether genetically determined MBL deficiency is related to vertical HIV transmission and disease progression in HIV-infected children...
- Bone mineral density increases in HIV-infected children treated with long-term combination antiretroviral therapyMadeleine J Bunders
Department of Paediatric Immunology, Haematology, and Infectious Diseases, Emma Children Hospital, Amsterdam, The Netherlands
Clin Infect Dis 56:583-6. 2013..Longitudinal data on bone mineral density (BMD) in HIV-infected children showed that cumulative treatment with cART had a positive impact on BMD over time...
- Noncirrhotic Portal Hypertension in Perinatally HIV-infected Adolescents Treated With Didanosine-containing Antiretroviral Regimens in ChildhoodHenriette J Scherpbier
From the Department of Pediatric Hematology, Immunology and Infectious Diseases, and Department of Pathology, Emma Children s Hospital, Academic Medical Center AMC, Amsterdam, The Netherlands Department of Pathology, MCH Bronovo Hospital, The Hague, The Netherlands Faculty of Medicine, Chulalongkorn University and HIVNAT, Thai Red Cross AIDS Research Center, Bangkok, Thailand U S Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, and Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, Department of Infectious Diseases, Imperial College Healthcare NHS Trust, London, United Kingdom Department of Radiodiagnostics and Infectious Diseases, AMC and Department of Pediatric Gastroenterology, Emma Children s Hospital, AMC, Amsterdam, The Netherlands
Pediatr Infect Dis J 35:e248-52. 2016..Noncirrhotic portal hypertension (NCPH) has been reported in HIV-infected adults. Antiretroviral drugs, as well as genetic and thrombophilic predisposition, have been suggested as possible etiologic factors...
- Country of birth does not influence long-term clinical, virologic, and immunological outcome of HIV-infected children living in the Netherlands: a cohort study comparing children born in the Netherlands with children born in Sub-Saharan AfricaSophie Cohen
Department of Pediatric Haematology, Immunology and Infectious Diseases, Emma Children s Hospital, Academic Medical Center, Amsterdam, the Netherlands Dutch HIV Monitoring Foundation, Amsterdam, The Netherlands Department of Pediatrics, Division of Infectious Diseases, Immunology and Rheumatology, Erasmus MC University Hospital Rotterdam Sophia Children s Hospital, Rotterdam, the Netherlands Erasmus MC Viroscience Lab, Erasmus MC, Rotterdam, the Netherlands The Nijmegen Institute for Infection, Inflammation and Immunity, Radboud University Medical Center, Nijmegen, the Netherlands and Department of Pediatric Infectious Diseases and Immunology, Wilhelmina Children s Hospital University Medical Center, Utrecht, The Netherlands
J Acquir Immune Defic Syndr 68:178-85. 2015..We aimed to investigate potential differences in clinical, immunological, and virologic outcome in Dutch HIV-infected children born in the Netherlands (NL) versus born in Sub-Saharan Africa (SSA) in a national cohort analysis...