Ronald Oude-Elferink

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Yin Zhi Huang and other plant-derived preparations: where herbal and molecular medicine meet
    Ronald Oude Elferink
    Department of Gastrointest Liver Dis, Academic Medical Ctr FO 116, Meibergdreef 9, 1105 AZ, Amsterdam, Netherlands
    J Hepatol 41:691-3. 2004
  2. doi request reprint Lysophosphatidic acid and signaling in sensory neurons
    Ronald P J Oude Elferink
    Tytgat Institute for Liver and Intestinal Research, Academic Medical Center Amsterdam, Meibergdreef 69 71, 1105 BK Amsterdam, The Netherlands Electronic address
    Biochim Biophys Acta 1851:61-5. 2015
  3. pmc P4 ATPases: flippases in health and disease
    Vincent A van der Mark
    Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Meibergdreef 69 71, 1105 BK Amsterdam, The Netherlands
    Int J Mol Sci 14:7897-922. 2013
  4. ncbi request reprint Are pigs more human than mice?
    Ronald Oude Elferink
    Liver Center, Academic Medical Center, Meibergdreef 69 71, 1105BK Amsterdam, The Netherlands
    J Hepatol 50:838-41. 2009
  5. pmc Alteration of viral lipid composition by expression of the phospholipid floppase ABCB4 reduces HIV vector infectivity
    Niek P van Til
    AMC Liver Center, Meibergdreef 69, 1105 BK, Amsterdam, The Netherlands
    Retrovirology 5:14. 2008
  6. pmc Insulin-like growth factor binding protein 5 enhances survival of LX2 human hepatic stellate cells
    Aleksandar Sokolovic
    Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Fibrogenesis Tissue Repair 3:3. 2010
  7. pmc A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol
    Eric L Klett
    Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, Charleston, SC 29403, USA
    BMC Med 2:5. 2004
  8. pmc Reduction of liver macrophage transduction by pseudotyping lentiviral vectors with a fusion envelope from Autographa californica GP64 and Sendai virus F2 domain
    David M Markusic
    AMC Liver Center, Amsterdam, The Netherlands
    BMC Biotechnol 9:85. 2009
  9. pmc Novel immortalized human fetal liver cell line, cBAL111, has the potential to differentiate into functional hepatocytes
    Tanja Deurholt
    AMC Liver Center, Meibergdreef 69 71, 1105 BK Amsterdam, The Netherlands
    BMC Biotechnol 9:89. 2009
  10. doi request reprint Mediators of pruritus during cholestasis
    Ronald P J Oude Elferink
    Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands
    Curr Opin Gastroenterol 27:289-93. 2011

Collaborators

  • Ulrich Beuers
  • Albert K Groen
  • Atze T Das
  • David Markusic
  • Gert Fricker
  • P Borst
  • James Boyer
  • J Seppen
  • Andreas E Kremer
  • Willem Boers
  • H-U Marschall
  • C C Paulusma
  • Jose E Manautou
  • M Pinzani
  • NED BALLATORI
  • Ronald P J Oude Elferink
  • Ronald Oude Elferink
  • Ronald Pj Oude Elferink
  • Niek P van Til
  • Vincent A van der Mark
  • Aleksandar Sokolovic
  • Tanja Deurholt
  • R P J Oude Elferink
  • Noam Zelcer
  • Eric L Klett
  • R Oude Elferink
  • Ruth Bolier
  • Job J W W Martens
  • Piter J Bosma
  • Milka Sokolovic
  • R P Oude Elferink
  • Catherine Payne
  • Igor M Sauer
  • Lysbeth ten Bloemendaal
  • Aniska A Chhatta
  • Ruurdtje Hoekstra
  • Ruth Schwartlander
  • John N Plevris
  • Robert Afm Chamuleau
  • Michel van Wijland
  • Roos van der Rijt
  • Kirstin M Heutinck
  • R de Waart
  • Jan Wijnholds
  • R P Elferink
  • Rudi de Waart
  • Koen van de Wetering
  • Annemieke Kuil
  • George L Scheffer
  • Peter R Wielinga
  • Alexander Smith
  • Martin van der Valk
  • Cindy Kunne
  • Hongwei Yu
  • Sarah Shefer
  • Mi Hye Lee
  • Gerald Salen
  • Ashok K Batta
  • Roelof Ottenhoff
  • Shailendra B Patel
  • Nobuyo Maeda
  • Michael Altenburg
  • Kangmo Lu
  • Astrid Kosters
  • Norbert Looije
  • Edwin Vink
  • David J Seward
  • Richard Klein
  • Jianliang Chen
  • C M Frijters
  • R Ottenhoff
  • A J Smith
  • J Van Marle

Detail Information

Publications32

  1. ncbi request reprint Yin Zhi Huang and other plant-derived preparations: where herbal and molecular medicine meet
    Ronald Oude Elferink
    Department of Gastrointest Liver Dis, Academic Medical Ctr FO 116, Meibergdreef 9, 1105 AZ, Amsterdam, Netherlands
    J Hepatol 41:691-3. 2004
    ..CAR is a potential target for the development of new drugs to treat neonatal, genetic, or acquired forms of jaundice. [Abstract reproduced by permission of J Clin Invest 2004;113:137-143]...
  2. doi request reprint Lysophosphatidic acid and signaling in sensory neurons
    Ronald P J Oude Elferink
    Tytgat Institute for Liver and Intestinal Research, Academic Medical Center Amsterdam, Meibergdreef 69 71, 1105 BK Amsterdam, The Netherlands Electronic address
    Biochim Biophys Acta 1851:61-5. 2015
    ..The mechanism by which this occurs remains to be elucidated. This article is part of a Special Issue entitled Linking transcription to physiology in lipodomics. ..
  3. pmc P4 ATPases: flippases in health and disease
    Vincent A van der Mark
    Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Meibergdreef 69 71, 1105 BK Amsterdam, The Netherlands
    Int J Mol Sci 14:7897-922. 2013
    ..This review summarizes current knowledge on the basic function of these phospholipid translocating proteins, their proposed action in intracellular vesicle transport and their physiological role...
  4. ncbi request reprint Are pigs more human than mice?
    Ronald Oude Elferink
    Liver Center, Academic Medical Center, Meibergdreef 69 71, 1105BK Amsterdam, The Netherlands
    J Hepatol 50:838-41. 2009
  5. pmc Alteration of viral lipid composition by expression of the phospholipid floppase ABCB4 reduces HIV vector infectivity
    Niek P van Til
    AMC Liver Center, Meibergdreef 69, 1105 BK, Amsterdam, The Netherlands
    Retrovirology 5:14. 2008
    ..This property enabled us to modulate the lipid composition of HIV vectors and study the effects on membrane composition and infection efficiency...
  6. pmc Insulin-like growth factor binding protein 5 enhances survival of LX2 human hepatic stellate cells
    Aleksandar Sokolovic
    Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Fibrogenesis Tissue Repair 3:3. 2010
    ..This was confirmed in vivo in an animal model of liver fibrosis. Since IGFBP5 has been shown to promote fibrosis in other tissues, the aim of this study was to investigate its role in the progression of liver fibrosis...
  7. pmc A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol
    Eric L Klett
    Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, Charleston, SC 29403, USA
    BMC Med 2:5. 2004
    ..No phenotypic difference has yet been described in humans with complete defects in either ABCG5 or ABCG8. These proteins, based upon the defects in humans, are responsible for regulating dietary sterol entry and biliary sterol secretion...
  8. pmc Reduction of liver macrophage transduction by pseudotyping lentiviral vectors with a fusion envelope from Autographa californica GP64 and Sendai virus F2 domain
    David M Markusic
    AMC Liver Center, Amsterdam, The Netherlands
    BMC Biotechnol 9:85. 2009
    ..This results in a reduction of available virus and might also increase the immune response to the vector and vector products.Reduction of macrophage sequestration is therefore essential for efficient lentiviral liver gene therapy...
  9. pmc Novel immortalized human fetal liver cell line, cBAL111, has the potential to differentiate into functional hepatocytes
    Tanja Deurholt
    AMC Liver Center, Meibergdreef 69 71, 1105 BK Amsterdam, The Netherlands
    BMC Biotechnol 9:89. 2009
    ..Here we describe the generation and characterization of a clonal human cell line for in vitro hepatocyte applications...
  10. doi request reprint Mediators of pruritus during cholestasis
    Ronald P J Oude Elferink
    Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands
    Curr Opin Gastroenterol 27:289-93. 2011
    ..Pruritus is a frequent symptom in patients with cholestatic liver diseases. Itching may be excruciating, may seriously impair quality of life and even induce suicidal ideation in the most severe cases...
  11. doi request reprint The molecular mechanism of cholestatic pruritus
    Ronald P J Oude Elferink
    Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands
    Dig Dis 29:66-71. 2011
    ..LPA then activates these neurons through one of the LPA receptors, which in turn potentiates action potentials along itch fibers...
  12. doi request reprint Targeting the ABCB4 gene to control cholesterol homeostasis
    Ronald Pj Oude Elferink
    Tytgat Institute for Liver and Intestinal Research, Amsterdam, The Netherlands
    Expert Opin Ther Targets 15:1173-82. 2011
    ..This deficiency leads to the destruction of hepatocytes and cholangiocytes by bile salts, because their cytolytic action is not reduced by formation of mixed micelles with phospholipid...
  13. ncbi request reprint Transporters in the intestine limiting drug and toxin absorption
    R P J Oude Elferink
    AMC Liver Center, Academic Medical Center S1 162, Meibergdreef 69 71, 1105BK Amsterdam, The Netherlands
    J Physiol Biochem 63:75-81. 2007
    ..This combined activity strongly determines whether drugs have access to the systemic circulation...
  14. ncbi request reprint Increased serum concentrations of secondary bile salts during cholate feeding are due to coprophagy. A study with wild-type and Atp8b1-deficient mice
    Annemiek Groen
    AMC Liver Center, Academic Medical Center, Amsterdam, The Netherlands
    Mol Pharm 3:756-61. 2006
    ..Whether housed in conventional cages or in metabolic cages, wild-type and Atp8b1-deficient mice had similar concentrations in portal blood, suggesting that intestinal bile salt absorption is not altered in Atp8b1-deficient mice...
  15. ncbi request reprint Function and pathophysiological importance of ABCB4 (MDR3 P-glycoprotein)
    Ronald P J Oude Elferink
    AMC Liver Center, Academic Medical Center, Amsterdam, The Netherlands
    Pflugers Arch 453:601-10. 2007
    ..In this review, we will discuss the functional aspects of ABCB4 and the regulation of its expression. Furthermore, we will describe the clinical and biochemical consequences of complete and partial deficiency of ABCB4 function...
  16. pmc Class III P-glycoproteins mediate the formation of lipoprotein X in the mouse
    R P Elferink
    Department of Gastrointestinal and Liver Diseases, Academic Medical Center, Amsterdam, The Netherlands
    J Clin Invest 102:1749-57. 1998
    ..The concentration of this lipoprotein is determined by the activity of the canalicular phospholipid translocator...
  17. ncbi request reprint Hepatocanalicular transport defects: pathophysiologic mechanisms of rare diseases
    Ronald P J Oude Elferink
    AMC Liver Center, Academic Medical Center, Amsterdam, The Netherlands
    Gastroenterology 130:908-25. 2006
    ..In this review we only briefly discuss the inherited defects in transporter function, and we focus on the pathophysiologic concepts that these diseases have generated...
  18. ncbi request reprint Mechanisms of biliary lipid secretion and their role in lipid homeostasis
    R P Oude Elferink
    Lab Exp Hepatology, Academic Medical Center F0 116, Amsterdam, The Netherlands
    Semin Liver Dis 20:293-305. 2000
    ..In this review we discuss our current understanding of hepatocanalicular lipid secretion in this context. The pathologic consequences of defects in biliary lipid secretion are discussed in another review in this issue...
  19. ncbi request reprint Genetic defects in hepatobiliary transport
    Ronald Oude Elferink
    Laboratory for Experimental Hepatology, Academic Medical Center Amsterdam F0 116, Meibergdreef 9, 1105 AZ, Netherlands
    Biochim Biophys Acta 1586:129-45. 2002
    ..Four of these transporter genes are associated with inherited diseases. In this minireview we will shortly describe our present understanding of bile formation and the associated inherited defects...
  20. pmc Cholestasis
    R Oude Elferink
    Laboratory Experimental Hepatology, Academic Medical Centre, Amsterdam, The Netherlands
    Gut 52:ii42-8. 2003
    ..Indeed, it is now becoming clear that impaired or downregulated transporter function is also involved in the pathogenesis of acquired cholestatic syndromes...
  21. ncbi request reprint One step further towards real high-throughput functional genomics
    Ronald Oude Elferink
    AMC Liver Center, Academic Medical Center S2 162, Meibergdreef 69 71, Amsterdam, The Netherlands
    Trends Biotechnol 21:146-7; discussion 147-8. 2003
    ..This library can be used for arrayed transduction of cell lines in phenotypic assays and to screen for genes involved in the induction of any phenotype for which a robust high-throughput assay can be designed...
  22. ncbi request reprint Elucidation of the biliary secretion machinery
    Ronald Oude Elferink
    AMC Liver Center, Academic Medical Center, S1 162, Meibergdreef 69 71, 1105BK Amsterdam, The Netherlands
    Curr Gastroenterol Rep 5:439-40. 2003
  23. ncbi request reprint Lack of biliary lipid excretion in the little skate, Raja erinacea, indicates the absence of functional Mdr2, Abcg5, and Abcg8 transporters
    Ronald P J Oude Elferink
    AMC Liver Center, Academic Medical Center S1 162, Meibergdreef 69 71, 1105 BK Amsterdam
    Am J Physiol Gastrointest Liver Physiol 286:G762-8. 2004
    ..Little skate plasma membranes may be protected against bile salt micelles mainly by their high sphingomyelin content...
  24. ncbi request reprint The start of a new era in bile physiology
    Ronald Oude Elferink
    Department of Gastrointestinal Liver Disease, Academic Medical Ctr FO 116, Meibergdreef 69 71, 1105 BK Amsterdam, The Netherlands
    J Hepatol 41:902-4. 2004
  25. ncbi request reprint Manipulation of biliary lipids by gene therapy: potential consequences for patients with progressive familial intrahepatic cholestasis
    Ronald P J Oude Elferink
    Amsterdam Liver Center, Academic Medical Center, Amsterdam, The Netherlands
    Curr Drug Targets Immune Endocr Metabol Disord 5:199-202. 2005
    ..Problems and possibilities are discussed with the inherited disease, Progressive Familial Intrahepatic Cholestasis, as an example...
  26. ncbi request reprint Mammalian ABC transporters in health and disease
    P Borst
    Division of Molecular Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands
    Annu Rev Biochem 71:537-92. 2002
    ..c) A rapidly increasing number of ABC transporters are found to play a role in lipid transport. Defects in each of these transporters are involved in human inborn or acquired diseases...
  27. ncbi request reprint Transcriptional profiling reveals novel markers of liver fibrogenesis: gremlin and insulin-like growth factor-binding proteins
    Willem Boers
    AMC Liver Center, Academic Medical Center, University of Amsterdam, Meibergdreef 69 71, 1105 BK Amsterdam, The Netherlands
    J Biol Chem 281:16289-95. 2006
    ..In conclusion, the comparison of the three transcriptomes of (activated) stellate cells reveals novel genes involved in fibrogenesis and provides an appreciation of the sequence and timing of the fibrotic process in liver...
  28. pmc Comparison of single regulated lentiviral vectors with rtTA expression driven by an autoregulatory loop or a constitutive promoter
    David Markusic
    AMC Liver Center S1 172, Meibergdreef 69, 1105BK Amsterdam, The Netherlands
    Nucleic Acids Res 33:e63. 2005
    ..This lentiviral vector with doxycycline-regulated transgene expression may be useful for gene therapy applications and in experimental settings where strict temporal expression of a transgene is required...
  29. doi request reprint Small animal models of hepatocyte transplantation
    Jurgen Seppen
    AMC Liver Center, Amsterdam, The Netherlands
    Methods Mol Biol 481:75-82. 2009
    ..Protocols for the collection of bile in rats and mice are described, and we have also detailed the detection of green fluorescent protein (GFP)-labelled human hepatocytes in immunodeficient mice in this chapter...
  30. ncbi request reprint Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but altered hepatic transport of endogenous glucuronides
    Noam Zelcer
    Division of Molecular Biology, H8, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Hepatol 44:768-75. 2006
    ..Multidrug Resistance Protein 3 (MRP3) transports bile salts and glucuronide conjugates in vitro and is postulated to protect the liver in cholestasis. Whether the absence of Mrp3 affects these processes in vivo is tested...
  31. ncbi request reprint Altered disposition of acetaminophen in mice with a disruption of the Mrp3 gene
    Jose E Manautou
    Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, USA
    Hepatology 42:1091-8. 2005
    ..In its absence, sufficient hepatic accumulation occurs to redirect some of the APAP-GLUC to bile. This altered disposition in Mrp3-/- mice is associated with reduced hepatotoxicity...