Peter L M Jansen

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint [Consequences of non-alcoholic fatty liver disease still unclear]
    Peter L M Jansen
    Academisch Medisch Centrum, afd Maag, Darm, leverziekten, Amsterdam, The Netherlands
    Ned Tijdschr Geneeskd 156:A4568. 2012
  2. doi request reprint Alterations of hormonally active fibroblast growth factors after Roux-en-Y gastric bypass surgery
    Peter L M Jansen
    Department of Gastrointestinal and Liver Disease, Academic Medical Center, Amsterdam, The Netherlands
    Dig Dis 29:48-51. 2011
  3. ncbi request reprint [Nonalcoholic steatohepatitis: diagnosis, pathogenesis, treatment and prognosis]
    P L M Jansen
    Academisch Medisch Centrum Universiteit van Amsterdam, afd Maag, Darm en Leverziekten, Levercentrum, Meibergdreefg, 1105 AZ Amsterdam
    Ned Tijdschr Geneeskd 149:289-94. 2005
  4. ncbi request reprint [Improved survival and less hepatocellar carcinoma following the successful treatment of chornic hepatitis B]
    P L M Jansen
    Academisch Medisch Centrum Universiteit van Amsterdam, afd Maag, Darm en Leverziekten, Levercentrum, Meibergdreef 9, 1105 AZ Amsterdam
    Ned Tijdschr Geneeskd 149:1495-7. 2005
  5. doi request reprint A new life for bile acids
    Peter L M Jansen
    Department of Gastrointestinal and Liver Disease, Academic Medical Center, Amsterdam, The Netherlands
    J Hepatol 52:937-8. 2010
  6. doi request reprint Controlled-release interferon alpha 2b, a new member of the interferon family for the treatment of chronic hepatitis C
    Peter L M Jansen
    Academic Medical Center, Department of Gastroenterology and Hepatology, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Expert Opin Investig Drugs 21:111-8. 2012
  7. doi request reprint Hepatocellular carcinoma in cirrhotic versus noncirrhotic livers: results from a large cohort in the Netherlands
    Suzanne van Meer
    aDepartment of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht Departments of bGastroenterology and Hepatology cSurgery, Erasmus Medical Center, Rotterdam dDepartment of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden Departments of eMedical Oncology fGastroenterology and Hepatology gPathology, Academic Medical Center Amsterdam hDepartment of Gastroenterology and Hepatology, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Gastroenterol Hepatol 28:352-9. 2016
  8. doi request reprint Up-regulation and cytoprotective role of epithelial multidrug resistance-associated protein 1 in inflammatory bowel disease
    Hans Blokzijl
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, 9700 RB, Groningen, The Netherlands
    J Biol Chem 283:35630-7. 2008
  9. doi request reprint US cannot be used to predict the presence or severity of hepatic steatosis in severely obese adolescents
    Anneloes E Bohte
    Department of Radiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, The Netherlands
    Radiology 262:327-34. 2012
  10. doi request reprint Hepatocellular carcinoma in noncirrhotic livers is associated with steatosis rather than steatohepatitis: potential implications for pathogenesis
    Suzanne van Meer
    aDepartment of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht bDepartment of Gastroenterology and Hepatology cDepartment of Surgery, Erasmus Medical Center, Rotterdam dDepartment of Medical Oncology eDepartment of Gastroenterology and Hepatology fDepartment of Pathology, Academic Medical Center Amsterdam, Amsterdam, The Netherlands
    Eur J Gastroenterol Hepatol 28:955-62. 2016

Detail Information

Publications50

  1. ncbi request reprint [Consequences of non-alcoholic fatty liver disease still unclear]
    Peter L M Jansen
    Academisch Medisch Centrum, afd Maag, Darm, leverziekten, Amsterdam, The Netherlands
    Ned Tijdschr Geneeskd 156:A4568. 2012
    ..But questions arise about the diagnostic methods in this study and the consequences for daily practice. Is NAFLD really a disease, and what is the diagnostic method of choice?..
  2. doi request reprint Alterations of hormonally active fibroblast growth factors after Roux-en-Y gastric bypass surgery
    Peter L M Jansen
    Department of Gastrointestinal and Liver Disease, Academic Medical Center, Amsterdam, The Netherlands
    Dig Dis 29:48-51. 2011
    ..Bile salts may play a key role in the improvement of metabolism after RYGB. Why serum bile salt concentrations are elevated after RYGB needs to be investigated...
  3. ncbi request reprint [Nonalcoholic steatohepatitis: diagnosis, pathogenesis, treatment and prognosis]
    P L M Jansen
    Academisch Medisch Centrum Universiteit van Amsterdam, afd Maag, Darm en Leverziekten, Levercentrum, Meibergdreefg, 1105 AZ Amsterdam
    Ned Tijdschr Geneeskd 149:289-94. 2005
    ..Drugs against insulin resistance can ameliorate nonalcoholic steatohepatitis. Gradual weight loss, a diet including polyunsaturated fatty acids and exercise are other important treatment components of this condition...
  4. ncbi request reprint [Improved survival and less hepatocellar carcinoma following the successful treatment of chornic hepatitis B]
    P L M Jansen
    Academisch Medisch Centrum Universiteit van Amsterdam, afd Maag, Darm en Leverziekten, Levercentrum, Meibergdreef 9, 1105 AZ Amsterdam
    Ned Tijdschr Geneeskd 149:1495-7. 2005
    ....
  5. doi request reprint A new life for bile acids
    Peter L M Jansen
    Department of Gastrointestinal and Liver Disease, Academic Medical Center, Amsterdam, The Netherlands
    J Hepatol 52:937-8. 2010
    ....
  6. doi request reprint Controlled-release interferon alpha 2b, a new member of the interferon family for the treatment of chronic hepatitis C
    Peter L M Jansen
    Academic Medical Center, Department of Gastroenterology and Hepatology, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Expert Opin Investig Drugs 21:111-8. 2012
    ..The side effects of Peg-interferon are a main disadvantage and represent a stumbling block for many patients to enter and continue therapy...
  7. doi request reprint Hepatocellular carcinoma in cirrhotic versus noncirrhotic livers: results from a large cohort in the Netherlands
    Suzanne van Meer
    aDepartment of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht Departments of bGastroenterology and Hepatology cSurgery, Erasmus Medical Center, Rotterdam dDepartment of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden Departments of eMedical Oncology fGastroenterology and Hepatology gPathology, Academic Medical Center Amsterdam hDepartment of Gastroenterology and Hepatology, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Gastroenterol Hepatol 28:352-9. 2016
    ..In the present study we explored associated risk factors for HCC without cirrhosis and compared patient and tumor characteristics and outcomes in HCC patients with and without underlying cirrhosis...
  8. doi request reprint Up-regulation and cytoprotective role of epithelial multidrug resistance-associated protein 1 in inflammatory bowel disease
    Hans Blokzijl
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, 9700 RB, Groningen, The Netherlands
    J Biol Chem 283:35630-7. 2008
    ..These data show that MRP1 protects intestinal epithelial cells against inflammation-induced apoptotic cell death and provides a functional role for MRP1 in the inflamed intestinal epithelium of IBD patients...
  9. doi request reprint US cannot be used to predict the presence or severity of hepatic steatosis in severely obese adolescents
    Anneloes E Bohte
    Department of Radiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, The Netherlands
    Radiology 262:327-34. 2012
    ....
  10. doi request reprint Hepatocellular carcinoma in noncirrhotic livers is associated with steatosis rather than steatohepatitis: potential implications for pathogenesis
    Suzanne van Meer
    aDepartment of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht bDepartment of Gastroenterology and Hepatology cDepartment of Surgery, Erasmus Medical Center, Rotterdam dDepartment of Medical Oncology eDepartment of Gastroenterology and Hepatology fDepartment of Pathology, Academic Medical Center Amsterdam, Amsterdam, The Netherlands
    Eur J Gastroenterol Hepatol 28:955-62. 2016
    ..As histological features of NAFLD may regress in cirrhosis, we compared steatosis versus steatohepatitis in the nontumoral liver of noncirrhotic HCC patients...
  11. doi request reprint Safety and antiviral activity of JTK-652: a novel HCV infection inhibitor
    Joep de Bruijne
    Department of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, The Netherlands
    Antivir Ther 15:765-73. 2010
    ..This study describes the in vitro and in vivo development of JTK-652, a novel pyrrolopyridazin-derived HCV infection inhibitor...
  12. doi request reprint High expression of the bile salt-homeostatic hormone fibroblast growth factor 19 in the liver of patients with extrahepatic cholestasis
    Frank G Schaap
    AMC Liver Center, Amsterdam, The Netherlands
    Hepatology 49:1228-35. 2009
    ....
  13. doi request reprint Hepatic steatosis in morbidly obese patients undergoing gastric bypass surgery: assessment with open-system 1H-MR spectroscopy
    Jochem R van Werven
    Department of Radiology, Academic Medical Center, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands
    AJR Am J Roentgenol 196:W736-42. 2011
    ..The purpose of this study was to assess, with histopathologic control, the use of open-system 1-T (1)H MR spectroscopy for the evaluation of hepatic steatosis in morbidly obese patients undergoing gastric bypass surgery...
  14. doi request reprint The hepatic response to FGF19 is impaired in patients with nonalcoholic fatty liver disease and insulin resistance
    Tim C M A Schreuder
    Academic Medical Center, Department of Gastroenterology, Amsterdam
    Am J Physiol Gastrointest Liver Physiol 298:G440-5. 2010
    ..However, the hepatic response to FGF19 is impaired in NAFLD patients with insulin resistance (HOMA score > or =2.5). This impaired hepatic response to FGF19 may contribute to the dysregulation of lipid homeostasis in NAFLD...
  15. doi request reprint Comparison of interobserver agreement of magnetic resonance elastography with histopathological staging of liver fibrosis
    Jurgen H Runge
    Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Abdom Imaging 39:283-90. 2014
    ..The objective of this study was to perform a head-to-head comparison of the interobserver agreements of MRE and liver fibrosis staging on biopsy in a single cohort of hepatitis patients...
  16. ncbi request reprint Monocyte-derived dendritic cells from chronic HCV patients are not infected but show an immature phenotype and aberrant cytokine profile
    Huub C Gelderblom
    Department of Gastroenterology and Hepatology, AMC Liver Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Liver Int 27:944-53. 2007
    ..Therefore, we studied the presence of HCV RNA in monocytes and monocyte-derived DCs from chronic HCV patients...
  17. ncbi request reprint Decreased P-glycoprotein (P-gp/MDR1) expression in inflamed human intestinal epithelium is independent of PXR protein levels
    Hans Blokzijl
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Inflamm Bowel Dis 13:710-20. 2007
    ..Here we compared intestinal MDR1 mRNA and protein expression in uninflamed and inflamed intestinal epithelium (IE) of patients with gastrointestinal inflammatory disorders to healthy controls...
  18. doi request reprint Nonalcoholic fatty liver disease and cardiovascular risk in children with obesity
    Bart G P Koot
    Department of Pediatric Gastroenterology and Nutrition, Emma Children s Hospital Academic Medical Center, Amsterdam, The Netherlands
    Obesity (Silver Spring) 23:1239-43. 2015
    ..Nonalcoholic fatty liver disease (NAFLD) has been recognized as an independent risk factor for cardiovascular disease in adults. It has not been established whether NAFLD is related to early atherosclerotic changes in children...
  19. pmc Liver fibrosis in type I Gaucher disease: magnetic resonance imaging, transient elastography and parameters of iron storage
    Anneloes E Bohte
    Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 8:e57507. 2013
    ..We recommend that all splenectomized patients, especially those with evidence of substantial liver fibrosis undergo regular screening for HCC, according to current guidelines...
  20. ncbi request reprint High incidence of type 1 diabetes mellitus during or shortly after treatment with pegylated interferon alpha for chronic hepatitis C virus infection
    Tim C M A Schreuder
    Department of Gastroenterology and Hepatology, AMC Liver Centre, University of Amsterdam, Amsterdam, The Netherlands
    Liver Int 28:39-46. 2008
    ..We prospectively screened for DM during and after IFN-alpha therapy for chronic HCV infection...
  21. doi request reprint Low retinol levels differentially modulate bile salt-induced expression of human and mouse hepatic bile salt transporters
    Martijn O Hoeke
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Hepatology 49:151-9. 2009
    ..Ntcp protein expression was strongly reduced in CA-fed VAD mice, whereas mRNA levels were normal. CA-fed control and VAD mice had similarly increased serum bile salt levels...
  22. doi request reprint Detection of hepatitis B virus covalently closed circular DNA in paraffin-embedded and cryo-preserved liver biopsies of chronic hepatitis B patients
    R Bart Takkenberg
    Department of Gastroenterology and Hepatology, AMC Liver Center, Center for Infectious Disease and Immunology CINIMA, University of Amsterdam and Royal Tropical Institute, KIT Biomedical Research, Amsterdam, The Netherlands
    Eur J Gastroenterol Hepatol 22:952-60. 2010
    ..Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) may become an important predictor for treatment outcome or long-term follow-up...
  23. doi request reprint Fibroblast growth factor 21 is induced by endoplasmic reticulum stress
    Frank G Schaap
    Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Meibergdreef 69 71, 1105 BK Amsterdam, The Netherlands
    Biochimie 95:692-9. 2013
    ..Our findings suggest that increased cellular stress in fatty livers may underlie the elevated FGF21 levels observed in patients with NAFLD...
  24. doi request reprint The human gallbladder secretes fibroblast growth factor 19 into bile: towards defining the role of fibroblast growth factor 19 in the enterobiliary tract
    Serge J L B Zweers
    Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands
    Hepatology 55:575-83. 2012
    ..e., FGFR4 and βKlotho) are expressed in mucosal epithelial cells of the gallbladder and small intestine. FGF19 was found to activate signaling pathways in cell lines of cholangiocytic, enteroendocrine, and enterocytic origin...
  25. doi request reprint Non-invasive evaluation of liver fibrosis: a comparison of ultrasound-based transient elastography and MR elastography in patients with viral hepatitis B and C
    Anneloes E Bohte
    Department of Radiology, Academic Medical Center, Amsterdam, The Netherlands
    Eur Radiol 24:638-48. 2014
    ..To compare the diagnostic accuracy of TE and MRE and establish cutoff levels and diagnostic strategies for both techniques, enabling selection of patients for liver biopsy...
  26. doi request reprint Lifestyle intervention for non-alcoholic fatty liver disease: prospective cohort study of its efficacy and factors related to improvement
    Bart G P Koot
    Department of Paediatric Gastroenterology and Nutrition, Emma Children s Hospital Academic Medical Centre, Amsterdam, The Netherlands
    Arch Dis Child 96:669-74. 2011
    ..Non-alcoholic fatty liver disease (NAFLD) has a high prevalence in obese children. Lifestyle intervention is the primary treatment for NAFLD. However, limited data are available regarding the efficacy of lifestyle interventions...
  27. doi request reprint Progressive familial intrahepatic cholestasis type 1
    Coen C Paulusma
    Tytgat Institute of Liver and Gastrointestinal Research and Department of Gastroenterology and Liver Disease, Academic Medical Center, Amsterdam, The Netherlands
    Semin Liver Dis 30:117-24. 2010
    ..The onset and resolution of the cholestatic episodes in these patients is still not well understood...
  28. doi request reprint Prediction of virologic response in difficult-to-treat chronic hepatitis C patients during high-dose interferon induction therapy
    Huub C Gelderblom
    AMC Liver Center, Department of Gastroenterology and Hepatology
    Scand J Gastroenterol 43:857-69. 2008
    ....
  29. ncbi request reprint Rapid decline of viral RNA in hepatitis C patients treated with VX-950: a phase Ib, placebo-controlled, randomized study
    Hendrik W Reesink
    Department of Gastroenterology and Hepatology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Gastroenterology 131:997-1002. 2006
    ..4A protease of hepatitis C and has antiviral activity in vitro. This phase I, placebo-controlled, double-blind study evaluated the antiviral activity, pharmacokinetics, and safety of VX-950 in patients with chronic hepatitis C (CHC)...
  30. ncbi request reprint Nonalcoholic steatohepatitis
    P L M Jansen
    Department of Gastroenterology and Hepatology, Academic Medical Centre, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    Neth J Med 62:217-24. 2004
    ..Insulin resistance is a major aetiological factor in NASH. Gradual weight loss, physical exercise and drugs that improve insulin sensitivity are potential therapies...
  31. doi request reprint Hepatic unsaturated fatty acids in patients with non-alcoholic fatty liver disease assessed by 3.0T MR spectroscopy
    J R van Werven
    Department of Radiology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Eur J Radiol 75:e102-7. 2010
    ..There is increasing evidence that hepatic UFA are associated with the development of NAFLD. Therefore the objective of this study was to assess hepatic UFA in patients with NAFLD using (1)H MRS...
  32. pmc Cholic acid therapy in Zellweger spectrum disorders
    Kevin Berendse
    Department of Pediatric Neurology, Emma Children s Hospital Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    J Inherit Metab Dis 39:859-868. 2016
    ..We investigated whether cholic acid supplementation can suppress bile acid synthesis, reduce accumulation of toxic bile acid intermediates and improve liver function in these patients...
  33. doi request reprint Adenosine triphosphate-binding cassette transporter genes up-regulation in untreated hepatocellular carcinoma is mediated by cellular microRNAs
    Florie Borel
    Department of Research and Development, Amsterdam Molecular Therapeutics, Amsterdam, The Netherlands
    Hepatology 55:821-32. 2012
    ..Correlation analysis between ABC and miRNA expression in individual patients revealed an inverse relationship, providing an indication for miRNA regulation of ABC genes in HCC...
  34. doi request reprint Using mass media and the Internet as tools to diagnose hepatitis C infections in the general population
    Freke R Zuure
    Cluster Infectious Diseases, Public Health Service of Amsterdam, Amsterdam, The Netherlands
    Am J Prev Med 40:345-52. 2011
    ..Many individuals with hepatitis C virus (HCV) infection are undiagnosed...
  35. doi request reprint PDGF-receptor beta-targeted adenovirus redirects gene transfer from hepatocytes to activated stellate cells
    Marieke H Schoemaker
    Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands
    Mol Pharm 5:399-406. 2008
    ..Our novel approach demonstrates that therapeutic genes can be selectively directed to stellate cells. This opens new possibilities for the treatment of liver fibrosis...
  36. ncbi request reprint Non-alcoholic steatohepatitis
    Peter L M Jansen
    Department of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, The Netherlands
    Eur J Gastroenterol Hepatol 16:1079-85. 2004
    ..In NASH the liver is programmed to lipogenesis rather than to glycogenesis and herein insulin-resistance plays a major role. Gradual weight loss, physical exercise and drugs that improve insulin sensitivity are potential therapies...
  37. ncbi request reprint Absence of association between the multidrug resistance (MDR1) gene and inflammatory bowel disease
    Liekele E Oostenbrug
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, The Netherlands
    Scand J Gastroenterol 41:1174-82. 2006
    ..The purpose of this study was to examine the involvement of this gene in IBD in a large population of Dutch patients with IBD and family-based controls...
  38. doi request reprint New developments in the antiviral treatment of hepatitis C
    J de Bruijne
    AMC Liver Center, Department of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Vox Sang 97:1-12. 2009
    ..These new antiviral agents are expected to improve treatment significantly with potentially shorter treatment duration. The most promising antiviral agents will be reviewed...
  39. doi request reprint The biliary HCO(3)(-) umbrella: a unifying hypothesis on pathogenetic and therapeutic aspects of fibrosing cholangiopathies
    Ulrich Beuers
    Department of Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Hepatology 52:1489-96. 2010
    ..Genetic and acquired functional defects leading to destabilization of the biliary HCO(3)(-) umbrella may contribute to development and progression of various forms of fibrosing/sclerosing cholangitis...
  40. ncbi request reprint Low-level HCV viraemia after initial response during antiviral therapy: transcription-mediated amplification predicts treatment failure
    Huub C Gelderblom
    Section of Clinical Virology, Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Antivir Ther 12:423-7. 2007
    ..We studied this phenomenon in subsets of patients...
  41. doi request reprint The ascending pathophysiology of cholestatic liver disease
    Peter L M Jansen
    Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Hepatology 65:722-738. 2017
    ..This review is meant to serve as a call to prioritize the development of biomarkers that help to obtain a better stratification of these diseases. (Hepatology 2017;65:722-738)...
  42. pmc Prolonged fibroblast growth factor 19 response in patients with primary sclerosing cholangitis after an oral chenodeoxycholic acid challenge
    Serge J Zweers
    Tytgat Institute for Liver and Intestinal Research, Amsterdam, The Netherlands
    Hepatol Int 11:132-140. 2017
    ..Here, we evaluated the bile salt receptor FXR/FGF19 gut-liver axis in PSC and PBC patients...
  43. doi request reprint Surveillance for hepatocellular carcinoma is associated with increased survival: Results from a large cohort in the Netherlands
    Suzanne van Meer
    Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Hepatol 63:1156-63. 2015
    ..Effectiveness of surveillance for hepatocellular carcinoma is controversial. We here explore its effects in "real life" clinical practice...
  44. ncbi request reprint [Bariatric surgery: part of a systematic approach to obesity]
    Peter L M Jansen
    Academisch Medisch Centrum, afd Maag, Darm en Leverziekten, Amsterdam
    Ned Tijdschr Geneeskd 156:A4754. 2013
    ..There is a new Dutch practice guideline on the treatment of morbid obesity in which conservative treatment is hardly covered. There is little evidence of the highest level to support the recommendations in this guideline. ..
  45. ncbi request reprint Clinical outcome of Crohn's disease according to the Vienna classification: disease location is a useful predictor of disease course
    Liekele E Oostenbrug
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, The Netherlands
    Eur J Gastroenterol Hepatol 18:255-61. 2006
    ..The aim of this study was to determine the usefulness of the Vienna classification in patient care and clinical studies...
  46. ncbi request reprint Human and rat bile acid-CoA:amino acid N-acyltransferase are liver-specific peroxisomal enzymes: implications for intracellular bile salt transport
    Antonella Pellicoro
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Hepatology 45:340-8. 2007
    ..When expressed in fibroblasts, GFP-tagged hBAAT localized to the cytosol, confirming earlier observations...
  47. doi request reprint Liver adenomatosis: re-evaluation of aetiology and management
    Reeta Vetelainen
    Department of Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Liver Int 28:499-508. 2008
    ..In recent reports, LA has been associated with hepatic steatosis, with potential implications for the management of this disease. The aim of this study was to determine prognosis and optimal management of patients with LA...
  48. doi request reprint Glycosylation of fibroblast growth factor receptor 4 is a key regulator of fibroblast growth factor 19-mediated down-regulation of cytochrome P450 7A1
    Vassilis Triantis
    Tytgat Institute for Liver and Intestinal Research, Amsterdam, The Netherlands
    Hepatology 52:656-66. 2010
    ..Only the terminal FGFR4 glycoform is phosphorylated upon FGF19 treatment of HepG2 cells, and this shows that only fully glycosylated FGFR4 is active in CYP7A1 down-regulation...
  49. doi request reprint Validation of a sensitive and specific real-time PCR for detection and quantitation of hepatitis B virus covalently closed circular DNA in plasma of chronic hepatitis B patients
    R B Takkenberg
    AMC Liver Center, Department of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Med Virol 81:988-95. 2009
    ..ALT levels and HAI-score were not correlated with plasma cccDNA levels. These findings suggest that cccDNA levels in plasma are not the result of increased hepatocyte degeneration, but indicate that other mechanisms might be responsible...
  50. pmc Expression of apoptosis related proteins during malignant progression in chronic ulcerative colitis
    C J van der Woude
    Departments of Gastroenterology and Hepatology, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    J Clin Pathol 58:811-4. 2005
    ..Chronic ulcerative colitis (CUC) is associated with increased risk of developing colon cancer through a dysplasia (intraepithelial neoplasia)-carcinoma sequence...