Marc Engelen

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. pmc High prevalence of primary adrenal insufficiency in Zellweger spectrum disorders
    Kevin Berendse
    Department of Paediatric Neurology, Emma Children s Hospital Academic Medical Centre, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands
    Orphanet J Rare Dis 9:133. 2014
  2. doi request reprint X-linked adrenoleukodystrophy: pathogenesis and treatment
    Marc Engelen
    Department of Pediatric Neurology Emma Children s Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, 1100 DD, The Netherlands
    Curr Neurol Neurosci Rep 14:486. 2014
  3. pmc X-linked adrenoleukodystrophy (X-ALD): clinical presentation and guidelines for diagnosis, follow-up and management
    Marc Engelen
    Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Orphanet J Rare Dis 7:51. 2012
  4. pmc A 64-year old man presenting with carotid artery occlusion and corticobasal syndrome: a case report
    Marc Engelen
    Department of Neurology, H2, 216, Academic Medical Center, University of Amsterdam, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    J Med Case Reports 5:357. 2011
  5. pmc Bezafibrate lowers very long-chain fatty acids in X-linked adrenoleukodystrophy fibroblasts by inhibiting fatty acid elongation
    Marc Engelen
    Department of Clinical Chemistry, Laboratory Genetic Metabolic Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Inherit Metab Dis 35:1137-45. 2012
  6. pmc Zellweger spectrum disorders: clinical manifestations in patients surviving into adulthood
    Kevin Berendse
    Department of Paediatric Neurology, Emma Children s Hospital, Academic Medical Centre AMC, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    J Inherit Metab Dis 39:93-106. 2016
  7. doi request reprint X-linked adrenoleukodystrophy in women: a cross-sectional cohort study
    Marc Engelen
    1 Department of Neurology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Brain 137:693-706. 2014
  8. pmc Bezafibrate for X-linked adrenoleukodystrophy
    Marc Engelen
    Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 7:e41013. 2012
  9. doi request reprint Hematopoietic cell transplantation does not prevent myelopathy in X-linked adrenoleukodystrophy: a retrospective study
    Bjorn M Van Geel
    Department of Neurology, Medical Center Alkmaar, Alkmaar, The Netherlands
    J Inherit Metab Dis 38:359-61. 2015
  10. pmc Zellweger spectrum disorders: clinical overview and management approach
    Femke C C Klouwer
    Department of Paediatric Neurology, Emma Children s Hospital, Academic Medical Center, University of Amsterdam, Meibergdreef 9, PO Box 22660, 1105 AZ, Amsterdam, The Netherlands
    Orphanet J Rare Dis 10:151. 2015

Collaborators

Detail Information

Publications14

  1. pmc High prevalence of primary adrenal insufficiency in Zellweger spectrum disorders
    Kevin Berendse
    Department of Paediatric Neurology, Emma Children s Hospital Academic Medical Centre, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands
    Orphanet J Rare Dis 9:133. 2014
    ..Primary adrenal insufficiency was found in 7/24 patients examined, with 4/7 being asymptomatic. Systematic evaluation of adrenal function, through a Synacthen test, should be included in the clinical management of these patients. ..
  2. doi request reprint X-linked adrenoleukodystrophy: pathogenesis and treatment
    Marc Engelen
    Department of Pediatric Neurology Emma Children s Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, 1100 DD, The Netherlands
    Curr Neurol Neurosci Rep 14:486. 2014
    ..This review proposes to simplify the classification of the clinical spectrum of X-ALD and reviews the largely unresolved pathophysiological mechanisms and the current treatment options. ..
  3. pmc X-linked adrenoleukodystrophy (X-ALD): clinical presentation and guidelines for diagnosis, follow-up and management
    Marc Engelen
    Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Orphanet J Rare Dis 7:51. 2012
    ..This review focuses on the diagnosis and management of patients with X-ALD and provides a guideline for clinicians that encounter patients with this highly complex disorder...
  4. pmc A 64-year old man presenting with carotid artery occlusion and corticobasal syndrome: a case report
    Marc Engelen
    Department of Neurology, H2, 216, Academic Medical Center, University of Amsterdam, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    J Med Case Reports 5:357. 2011
    ..abstract:..
  5. pmc Bezafibrate lowers very long-chain fatty acids in X-linked adrenoleukodystrophy fibroblasts by inhibiting fatty acid elongation
    Marc Engelen
    Department of Clinical Chemistry, Laboratory Genetic Metabolic Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Inherit Metab Dis 35:1137-45. 2012
    ..Taken together, our data indicate bezafibrate as a potential pharmacotherapeutic treatment for X-ALD. A clinical trial is currently ongoing to evaluate the effect in patients with X-ALD...
  6. pmc Zellweger spectrum disorders: clinical manifestations in patients surviving into adulthood
    Kevin Berendse
    Department of Paediatric Neurology, Emma Children s Hospital, Academic Medical Centre AMC, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    J Inherit Metab Dis 39:93-106. 2016
    ..We describe the natural history of patients with a Zellweger spectrum disorder (ZSD) surviving into adulthood...
  7. doi request reprint X-linked adrenoleukodystrophy in women: a cross-sectional cohort study
    Marc Engelen
    1 Department of Neurology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Brain 137:693-706. 2014
    ..ABCD1 mutation analysis deserves a place in diagnostic protocols for chronic non-compressive myelopathy. ..
  8. pmc Bezafibrate for X-linked adrenoleukodystrophy
    Marc Engelen
    Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 7:e41013. 2012
    ..Our future work is aimed at the identification of highly-specific inhibitors of ELOVL1 that act at much lower concentrations than BF and are well tolerated. BF appears to have no therapeutic utility in X-ALD...
  9. doi request reprint Hematopoietic cell transplantation does not prevent myelopathy in X-linked adrenoleukodystrophy: a retrospective study
    Bjorn M Van Geel
    Department of Neurology, Medical Center Alkmaar, Alkmaar, The Netherlands
    J Inherit Metab Dis 38:359-61. 2015
    ..Cerebral ALD is treated with haematopoetic cell transplantation (HCT). It is unknown if AMN still develops in patients with X-ALD that underwent HCT for cerebral ALD in childhood...
  10. pmc Zellweger spectrum disorders: clinical overview and management approach
    Femke C C Klouwer
    Department of Paediatric Neurology, Emma Children s Hospital, Academic Medical Center, University of Amsterdam, Meibergdreef 9, PO Box 22660, 1105 AZ, Amsterdam, The Netherlands
    Orphanet J Rare Dis 10:151. 2015
    ..This review focuses on the management of patients with a ZSD and provides recommendations for supportive therapeutic options for all those involved in the care for ZSD patients. ..
  11. doi request reprint Frequent occurrence of cerebral demyelination in adrenomyeloneuropathy
    Marlijn de Beer
    From the Department of Neurology M d B, Haga Hospital, The Hague the Department of Pediatric Neurology M E, Emma Children s Hospital, Amsterdam the Department of Neurology M E, B M v G, Academic Medical Center, University of Amsterdam and the Department of Neurology B M v G, Medical Center Alkmaar, The Netherlands
    Neurology 83:2227-31. 2014
    ..To study the frequency of additional cerebral demyelination in Dutch patients with adrenomyeloneuropathy (AMN)...
  12. doi request reprint Strokelike episodes and cutis marmorata telangiectatica congenita
    Sander M van Schaik
    Department of Pediatric Neurology, Academic Medical Center, Amsterdam, The Netherlands Department of Neurology, Saint Lucas Andreas Hospital, Amsterdam, The Netherlands
    J Child Neurol 30:129-32. 2015
    ..To our knowledge, this is the first report of a stenosis of an intracranial artery in a patient with cutis marmorata telangiectatica congenita. ..
  13. doi request reprint Peroxisomal leukoencephalopathy
    Bwee Tien Poll-The
    Department of Pediatric Neurology Pediatrics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Semin Neurol 32:42-50. 2012
    ....