Carina L Bos
Affiliation: Academic Medical Center
Country: The Netherlands
- Farnesyl protein transferase inhibition interferes with activation of MAP kinase family members in human peripheral blood monocytesWalter L Vervenne
Department of Medical Oncology, Academic Medical Center, Amsterdam, The Netherlands
Mol Med 8:857-62. 2002..Nevertheless, the importance for farnesyl protein transferase enzymatic activity for cellular physiology of untransformed cells remains poorly investigated...
- Prostanoids and prostanoid receptors in signal transductionCarina L Bos
Laboratory for Experimental Internal Medicine, G2 130, Academic Medical Center, Meibergdreef 9, NL 1105 AZ Amsterdam, The Netherlands
Int J Biochem Cell Biol 36:1187-205. 2004..The final cellular reaction to prostaglandin stimulation will most likely depend on combined effects of the above-mentioned levels of interaction between prostaglandins and their cellular receptors...
- Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemiaJudith Branger
Department of Infectious Diseases, Tropical Medicine, and AIDS, Academic Medical Center, and CLB and Laboratory for Clinical and Experimental Immunology, University of Amsterdam, Amsterdam, The Netherlands
J Immunol 168:4070-7. 2002..Furthermore, the anti-inflammatory potential of an oral p38 MAPK inhibitor in humans in vivo suggests that p38 MAPK inhibitors may provide a new therapeutic option in the treatment of inflammatory diseases...
- 5-Aminosalicylic acid inhibits cell cycle progression in a phospholipase D dependent manner in colorectal cancerBart Baan
Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands
Gut 61:1708-15. 2012..In vitro data suggest that, in colorectal cancer cells, 5-ASA induces cell cycle arrest, but the molecular mechanism leading to this arrest remains to be determined...
- Violacein synergistically increases 5-fluorouracil cytotoxicity, induces apoptosis and inhibits Akt-mediated signal transduction in human colorectal cancer cellsLiudmila L Kodach
Laboratory for Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
Carcinogenesis 27:508-16. 2006..Taken together, our findings suggest that violacein will be active in the treatment of colorectal tumors and offers new prospects for overcoming 5-FU resistance...
- Molecular mechanism of violacein-mediated human leukemia cell deathCarmen Verissima Ferreira
Departamento de Bioquimica, Universidade Estadual de Campinas, Sao Paulo, Brazil
Blood 104:1459-64. 2004..Hence, violacein represents the first member of a novel class of cytotoxic drugs mediating apoptosis of HL60 cells by way of the specific activation of TNF receptor 1...
- Tetrahydroxyquinone induces apoptosis of leukemia cells through diminished survival signalingAlexandre D Martins Cavagis
Departamento de Bioquimica, Instituto de Biologia, Universidade Estadual de Campinas, UNICAMP, Campinas, Sao Paulo, Brasil
Exp Hematol 34:188-96. 2006..Its potential as an anticancer drug has not been investigated...
- Protein phosphatase 2A is required for mesalazine-dependent inhibition of Wnt/beta-catenin pathway activityCarina L Bos
Laboratory of Experimental Oncology and Radiobiology, Department of Oncology, University of Amsterdam, The Netherlands
Carcinogenesis 27:2371-82. 2006..This study shows, using concentrations of mesalazine identical to concentrations seen in patients with inflammatory bowel disease, that mesalazine inhibits the Wnt/beta-catenin pathway via inhibition of PP2A...
- A promising action of riboflavin as a mediator of leukaemia cell deathAna Carolina Santos de Souza
Department of Biochemistry, State University of Campinas, Brazil
Apoptosis 11:1761-71. 2006....