J Booij

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. doi request reprint Imaging as tool to investigate psychoses and antipsychotics
    Jan Booij
    Department of Nuclear Medicine, University of Amsterdam, Amsterdam, The Netherlands
    Handb Exp Pharmacol . 2012
  2. pmc SERT-to-DAT ratios in early Parkinson's disease do not correlate with the development of dyskinesias
    Sven R Suwijn
    Department of Neurology, H2 225, Academic Medical Center, University of Amsterdam, PO Box 22660, Amsterdam 1100 DD, The Netherlands
    EJNMMI Res 3:44. 2013
  3. pmc No difference in striatal dopamine transporter availability between active smokers, ex-smokers and non-smokers using [123I]FP-CIT (DaTSCAN) and SPECT
    Gerda Thomsen
    Neurobiology Research Unit 9201, Rigshospitalet and Copenhagen University Hospital, Blegdamsvej 9, Copenhagen 2100, Denmark
    EJNMMI Res 3:39. 2013
  4. pmc Imaging of serotonin transporters with [123I]FP-CIT SPECT in the human hypothalamus
    Anke J Borgers
    Department of Endocrinology and Metabolism, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, Room F5 168, Amsterdam, 1105 AZ, The Netherlands
    EJNMMI Res 3:34. 2013
  5. pmc Lower striatal dopamine D2/3 receptor availability in obese compared with non-obese subjects
    Barbara A de Weijer
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam, 1105 AZ, The Netherlands
    EJNMMI Res 1:37. 2011
  6. ncbi request reprint The role of molecular imaging in the differential diagnosis of parkinsonism
    J Booij
    Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Q J Nucl Med Mol Imaging 56:17-26. 2012
  7. pmc The SPECT tracer [123I]ADAM binds selectively to serotonin transporters: a double-blind, placebo-controlled study in healthy young men
    Elsmarieke van de Giessen
    Graduate School Neurosciences Amsterdam, Department of Nuclear Medicine, University of Amsterdam, Academic Medical Center, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 37:1507-11. 2010
  8. ncbi request reprint Imaging of dopamine transporters with [123I]FP-CIT SPECT does not suggest a significant effect of age on the symptomatic threshold of disease in Parkinson's disease
    J Booij
    Graduate School of Neurosciences, Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    Synapse 39:101-8. 2001
  9. ncbi request reprint The clinical benefit of imaging striatal dopamine transporters with [123I]FP-CIT SPET in differentiating patients with presynaptic parkinsonism from those with other forms of parkinsonism
    J Booij
    Graduate School of Neurosciences, Department of Nuclear Medicine, F2 N, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Eur J Nucl Med 28:266-72. 2001
  10. ncbi request reprint Imaging of dopamine transporters in rats using high-resolution pinhole single-photon emission tomography
    Jan Booij
    Department of Nuclear Medicine, F2N, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 29:1221-4. 2002

Detail Information

Publications102 found, 100 shown here

  1. doi request reprint Imaging as tool to investigate psychoses and antipsychotics
    Jan Booij
    Department of Nuclear Medicine, University of Amsterdam, Amsterdam, The Netherlands
    Handb Exp Pharmacol . 2012
    ....
  2. pmc SERT-to-DAT ratios in early Parkinson's disease do not correlate with the development of dyskinesias
    Sven R Suwijn
    Department of Neurology, H2 225, Academic Medical Center, University of Amsterdam, PO Box 22660, Amsterdam 1100 DD, The Netherlands
    EJNMMI Res 3:44. 2013
    ..Based on this model, we hypothesized that dyskinesias will develop predominantly in PD patients with a relatively preserved serotonergic system...
  3. pmc No difference in striatal dopamine transporter availability between active smokers, ex-smokers and non-smokers using [123I]FP-CIT (DaTSCAN) and SPECT
    Gerda Thomsen
    Neurobiology Research Unit 9201, Rigshospitalet and Copenhagen University Hospital, Blegdamsvej 9, Copenhagen 2100, Denmark
    EJNMMI Res 3:39. 2013
    ..We used the database to test the hypothesis that striatal DAT availability is changed in active smokers compared to non-smokers and ex-smokers...
  4. pmc Imaging of serotonin transporters with [123I]FP-CIT SPECT in the human hypothalamus
    Anke J Borgers
    Department of Endocrinology and Metabolism, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, Room F5 168, Amsterdam, 1105 AZ, The Netherlands
    EJNMMI Res 3:34. 2013
    ..Additionally, we tested the hypothesis that hypothalamic SERT binding ratios are different between patients with hypothalamic impairment (HI), pituitary insufficiency (PI), and control subjects (C)...
  5. pmc Lower striatal dopamine D2/3 receptor availability in obese compared with non-obese subjects
    Barbara A de Weijer
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam, 1105 AZ, The Netherlands
    EJNMMI Res 1:37. 2011
    ..One of the factors involved in the regulation of food intake and satiety is dopaminergic signalling. A small number of studies have reported that striatal dopamine D2/D3 receptor [D2/3R] availability is lower in morbidly obese subjects...
  6. ncbi request reprint The role of molecular imaging in the differential diagnosis of parkinsonism
    J Booij
    Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Q J Nucl Med Mol Imaging 56:17-26. 2012
    ..Finally, both brain [18F]FDG PET and cardiac sympathetic imaging are very promising tools to differentiate different parkinsonian syndromes from each other in routine clinical studies...
  7. pmc The SPECT tracer [123I]ADAM binds selectively to serotonin transporters: a double-blind, placebo-controlled study in healthy young men
    Elsmarieke van de Giessen
    Graduate School Neurosciences Amsterdam, Department of Nuclear Medicine, University of Amsterdam, Academic Medical Center, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 37:1507-11. 2010
    ..Moreover, initial human studies have shown that [(123)I]ADAM binding could be blocked by selective serotonin reuptake inhibitors (SSRIs). However, in humans it has not been proven that [(123)I]ADAM binds selectively to SERTs...
  8. ncbi request reprint Imaging of dopamine transporters with [123I]FP-CIT SPECT does not suggest a significant effect of age on the symptomatic threshold of disease in Parkinson's disease
    J Booij
    Graduate School of Neurosciences, Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    Synapse 39:101-8. 2001
    ..By using age-corrected data, we estimated that in our particular patient group motor signs started when the loss of [123I]FP-CIT binding ratios in the putamen was 46-64%...
  9. ncbi request reprint The clinical benefit of imaging striatal dopamine transporters with [123I]FP-CIT SPET in differentiating patients with presynaptic parkinsonism from those with other forms of parkinsonism
    J Booij
    Graduate School of Neurosciences, Department of Nuclear Medicine, F2 N, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Eur J Nucl Med 28:266-72. 2001
    ....
  10. ncbi request reprint Imaging of dopamine transporters in rats using high-resolution pinhole single-photon emission tomography
    Jan Booij
    Department of Nuclear Medicine, F2N, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 29:1221-4. 2002
    ..4) side. The preliminary results of this study indicate that semi-quantitative assessment of striatal dopamine transporter density using our recently developed high-resolution single-pinhole SPET system is feasible in living rat brain...
  11. ncbi request reprint Imaging of striatal dopamine transporters in rat brain with single pinhole SPECT and co-aligned MRI is highly reproducible
    Jan Booij
    Department of Nuclear Medicine, University of Amsterdam, Academic Medical Center, Amsterdam, The Netherlands
    Nucl Med Biol 30:643-9. 2003
    ..7 +/- 0.2 and 1.6 +/- 0.2, respectively. The test/retest variability was approximately 9%. We conclude that the assessment of striatal [(123)I]FP-CIT binding ratios in rats is highly reproducible...
  12. ncbi request reprint Brain kinetics of the new selective serotonin transporter tracer [(123)I]ADAM in healthy young adults
    Jan Booij
    Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Nucl Med Biol 33:185-91. 2006
    ..The purpose of this study was to develop an [(123)I]ADAM SPECT protocol for clinical studies in young adults...
  13. ncbi request reprint Repeated administration of D-amphetamine induces loss of [123I]FP-CIT binding to striatal dopamine transporters in rat brain: a validation study
    Jan Booij
    Department of Nuclear Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands
    Nucl Med Biol 33:409-11. 2006
    ..We therefore examined if repeated administration of D-AMPH or methamphetamine (METH) may induce loss of binding to striatal DATs in rats by using an experimental biodistribution study design and a SPECT tracer for the DAT ([123I]FP-CIT)...
  14. ncbi request reprint Quantification of striatal dopamine transporters with 123I-FP-CIT SPECT is influenced by the selective serotonin reuptake inhibitor paroxetine: a double-blind, placebo-controlled, crossover study in healthy control subjects
    Jan Booij
    Department of Nuclear Medicine, University of Amsterdam, Academic Medical Center, Amsterdam, The Netherlands
    J Nucl Med 48:359-66. 2007
    ..Moreover, we hypothesized that (123)I-FP-CIT in humans binds not only to DATs but also to central and peripheral SERTs...
  15. ncbi request reprint Dopamine transporter imaging with [(123)I]FP-CIT SPECT: potential effects of drugs
    Jan Booij
    Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 35:424-38. 2008
    ..Moreover, in preclinical studies, animals will be anesthetized. Prescribed drugs, drugs of abuse, and anesthetics may influence the visual interpretation and/or quantification of [(123)I]FP-CIT SPECT scans...
  16. doi request reprint SPECT imaging of the dopaminergic system in (premotor) Parkinson's disease
    Jan Booij
    Department of Nuclear Medicine, Academic Medical Centre, University of Amsterdam Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Parkinsonism Relat Disord 13:S425-8. 2007
    ....
  17. doi request reprint Unexpected detection of nodular melanoma of the skin on the scalp by I-123 IBZM brain SPECT
    Jan Booij
    Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Clin Nucl Med 36:148-9. 2011
    ..Melanoma should be considered when one is confronted with atypical focal uptake of benzamide derivatives like IBZM, in or outside the brain...
  18. doi request reprint Monitoring therapeutic effects in Parkinson's disease by serial imaging of the nigrostriatal dopaminergic pathway
    Jan Booij
    Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    J Neurol Sci 310:40-3. 2011
    ....
  19. ncbi request reprint Dopamine transporter density in young patients with schizophrenia assessed with [123]FP-CIT SPECT
    J Lavalaye
    Department of Psychiatry, Academic Medical Center, Tafelbergweg 25, 1105 BC Amsterdam, The Netherlands
    Schizophr Res 47:59-67. 2001
    ..56, p=0.014).Concluding, functional changes in the dopaminergic system in schizophrenia are not likely to be reflected in a change in DA transporter density. Moreover, DA transporter density does not seem to be altered by AP medication...
  20. ncbi request reprint Comparative in vivo study of iodine-123-labeled beta-CIT and nor-beta-CIT binding to serotonin transporters in rat brain
    L Reneman
    Graduate School of Neurosciences, Department of Nuclear Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Synapse 34:77-80. 1999
    ....
  21. ncbi request reprint Dopamine D2 receptor occupancy by olanzapine or risperidone in young patients with schizophrenia
    J Lavalaye
    Department of Psychiatry, Academic Medical Centre, Amsterdam, The Netherlands
    Psychiatry Res 92:33-44. 1999
    ..The lower incidence of prolactin elevation with olanzapine, compared to risperidone, may not be attributed to a lower D2 receptor occupancy...
  22. ncbi request reprint Addition of a 5-HT receptor agonist to methylphenidate potentiates the reduction of [123I]FP-CIT binding to dopamine transporters in rat frontal cortex and hippocampus
    L Reneman
    Graduate School of Neurosciences, Department of Nuclear Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands
    Synapse 39:193-200. 2001
    ..These findings suggest potential harmful effects of concomitant use of drugs directly activating 5-HT2 receptors in patients using methylphenidate...
  23. ncbi request reprint Subjective experience and striatal dopamine D(2) receptor occupancy in patients with schizophrenia stabilized by olanzapine or risperidone
    L de Haan
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, The Netherlands
    Am J Psychiatry 157:1019-20. 2000
    ..The authors' goal was to study the relationship between subjective experience during treatment with olanzapine or risperidone and dopamine D(2) receptor occupancy in stabilized patients with schizophrenia...
  24. ncbi request reprint Effect of age and gender on dopamine transporter imaging with [123I]FP-CIT SPET in healthy volunteers
    J Lavalaye
    Graduate School of Neurosciences Amsterdam, Department of Nuclear Medicine, Academic Medical Center, The Netherlands
    Eur J Nucl Med 27:867-9. 2000
    ..The intriguing finding of a higher dopamine transporter density in females than in males is in line with findings from animal studies...
  25. ncbi request reprint [123I]FP-CIT SPECT is a useful method to monitor the rate of dopaminergic degeneration in early-stage Parkinson's disease
    A Winogrodzka
    Graduate School for Neurosciences, Amsterdam, The Netherlands
    J Neural Transm (Vienna) 108:1011-9. 2001
    ..Our findings indicate that [123I]FP-CIT SPECT seems to be a useful tool to investigate the progression of dopaminergic degeneration in PD and may provide an objective method of measuring the effectiveness of neuroprotective therapies...
  26. doi request reprint Monoaminergic dysfunction in recreational users of dexamphetamine
    M L J Schouw
    Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Brain Imaging Center at the Academic Medical Centre, Amsterdam, The Netherlands Electronic address
    Eur Neuropsychopharmacol 23:1491-502. 2013
    ....
  27. doi request reprint Mapping serotonergic dysfunction in MDMA (ecstasy) users using pharmacological MRI
    M L J Schouw
    Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Eur Neuropsychopharmacol 22:537-45. 2012
    ..MDMA users had higher impulsivity scores and felt more uncomfortable after citalopram infusion, compared with control subjects. Our findings indicate that phMRI is very well suited for in-vivo assessment of 5-HT dysfunction...
  28. doi request reprint Quantitative agreement between [(15)O]H2O PET and model free QUASAR MRI-derived cerebral blood flow and arterial blood volume
    D F R Heijtel
    Department of Radiology, Academic Medical Center, Amsterdam, The Netherlands
    NMR Biomed 29:519-26. 2016
    ..In conclusion, the results of this study demonstrate that QUASAR MRI and [(15)O]H2O PET provide similar CBF and CBVA information, but with systematic quantitative discrepancies...
  29. doi request reprint Striatal D₂ receptor binding in 22q11 deletion syndrome: an [¹²³I]IBZM SPECT study
    E Boot
    Department of Psychiatry, Academic Medical Centre, University of Amsterdam, The Netherlands, Ipse de Bruggen, Centre for People with Intellectual Disability, Zwammerdam, The Netherlands
    J Psychopharmacol 24:1525-31. 2010
    ..However, the disturbed relationship between D₂R BP(ND) and pPRL values suggests DAergic dysfunction at a different level. Further studies on DAergic function in extra-striatal brain regions and under challenged conditions are needed...
  30. ncbi request reprint Dopamine transporter density in patients with tardive dyskinesia: a single photon emission computed tomography study
    J Lavalaye
    Department of Nuclear Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Psychopharmacology (Berl) 155:107-9. 2001
    ..Tardive dyskinesia occurs frequently in schizophrenic patients chronically treated with classical antipsychotic medication. It may be caused by loss of dopaminergic cells, due to free radicals as a product of high synaptic dopamine levels...
  31. ncbi request reprint Cortical serotonin transporter density and verbal memory in individuals who stopped using 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy"): preliminary findings
    L Reneman
    Department of Nuclear Medicine, F2 210, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Arch Gen Psychiatry 58:901-6. 2001
    ..We investigated the long-term effects of MDMA use on cortical 5-HT neurons in humans and memory function, because brain 5-HT has been implicated in memory function...
  32. ncbi request reprint Rigidity decreases resting tremor intensity in Parkinson's disease: A [(123)I]beta-CIT SPECT study in early, nonmedicated patients
    A Winogrodzka
    Department of Neurology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    Mov Disord 16:1033-40. 2001
    ..Other pathophysiological mechanisms should be similarly investigated in order to further our understanding of the origin of resting tremor in PD...
  33. doi request reprint High fat/carbohydrate ratio but not total energy intake induces lower striatal dopamine D2/3 receptor availability in diet-induced obesity
    E van de Giessen
    Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Int J Obes (Lond) 37:754-7. 2013
    ....
  34. doi request reprint Incidental head and neck findings on MRI in young healthy volunteers: prevalence and clinical implications
    L Reneman
    Department of Neuroradiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    AJNR Am J Neuroradiol 33:1971-4. 2012
    ..2%). These findings suggest that a high prevalence of incidental findings is common in healthy young volunteers, though the clinical implications are negligible...
  35. doi request reprint Mapping the hemodynamic response in human subjects to a dopaminergic challenge with dextroamphetamine using ASL-based pharmacological MRI
    M L J Schouw
    Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Neuroimage 72:1-9. 2013
    ..Our observations are in line with literature and provide further evidence that ASL-based phMRI with dAMPH is a promising technique to assess DAergic function in human subjects...
  36. doi request reprint Varenicline increases striatal dopamine D(2/3) receptor binding in rats
    Cleo L Crunelle
    Amsterdam Institute for Addiction Research and Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Addict Biol 14:500-2. 2009
    ..Varenicline increases dopamine D(2/3) receptor availability in drug-naïve rats. Therefore, varenicline may be an effective treatment for addictions other than smoking...
  37. ncbi request reprint Preclinical (premotor) Parkinson's disease
    E C Wolters
    Department of Neurology, Academisch Ziekenhuis Vrije Universiteit, Amsterdam, The Netherlands
    J Neurol 247:II103-9. 2000
    ..In this report, the study design and initial data from this ongoing study will be presented...
  38. ncbi request reprint Early-stage [123I]beta-CIT SPECT and long-term clinical follow-up in patients with an initial diagnosis of Parkinson's disease
    Diederick Stoffers
    Department of Neurology, Institute for Clinical and Experimental Neurosciences, VU University Medical Center, P O Box 7057, 1007, MB, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 32:689-95. 2005
    ..We hypothesized that distinguishing SPECT features might be most pronounced at an early disease stage, and the purpose of the present study was to investigate this hypothesis...
  39. ncbi request reprint Striatal dopamine D2 receptor binding and dopamine release during cue-elicited craving in recently abstinent opiate-dependent males
    Fleur Zijlstra
    Department of Nuclear Medicine, Academic Medical Centre, Amsterdam, The Netherlands
    Eur Neuropsychopharmacol 18:262-70. 2008
    ..Chronic craving and anhedonia were positively correlated with DA release. Treatment strategies that increase D2Rs may, therefore, be an interesting approach to prevent relapse in opiate addiction...
  40. ncbi request reprint Leads for the development of neuroprotective treatment in Parkinson's disease and brain imaging methods for estimating treatment efficacy
    J C Stoof
    Department of Neurology, Research Institute for Neurosciences, Vrije Universiteit, Amsterdam, The Netherlands
    Eur J Pharmacol 375:75-86. 1999
    ....
  41. pmc Loss of thalamic serotonin transporters in early drug-naïve Parkinson's disease patients is associated with tremor: an [(123)I]beta-CIT SPECT study
    V Caretti
    Department of Neurology, Vrije University Medical Center, Amsterdam, The Netherlands
    J Neural Transm (Vienna) 115:721-9. 2008
    ..No correlation was found between BDI scores and thalamic binding ratios. Our findings show decline of [(123)I]beta-CIT binding to thalamic 5-HTT in PD and its possible contribution to tremor onset...
  42. ncbi request reprint Lack of perfusion enhancement after administration of nicotinamide and carbogen in patients with glioblastoma: a 99mTc-HMPAO SPECT study
    M C Hulshof
    Department of Radiotherapy, Academic Medical Center, University of Amsterdam, The Netherlands
    Radiother Oncol 48:135-42. 1998
    ..These agents have demonstrated to act against hypoxia and one of their underlying mechanisms could be an increase of tumour blood perfusion...
  43. ncbi request reprint Subclinical dopaminergic dysfunction in asymptomatic Parkinson's disease patients' relatives with a decreased sense of smell
    H W Berendse
    Department of Neurology, Research Institute Neurosciences, Vrije Universiteit, Amsterdam, The Netherlands
    Ann Neurol 50:34-41. 2001
    ..The results further indicate that olfactory deficits may precede clinical motor signs in PD...
  44. ncbi request reprint Higher occupancy of muscarinic receptors by olanzapine than risperidone in patients with schizophrenia. A[123I]-IDEX SPECT study
    J Lavalaye
    Department of Psychiatry, Academic Medical Center, Amsterdam, The Netherlands
    Psychopharmacology (Berl) 156:53-7. 2001
    ..Substantial occupancy of muscarinic receptors may be an explanation for the low incidence of extrapyramidal side effects induced by olanzapine...
  45. doi request reprint Functional MR imaging on an open 1T MR imaging system: exploiting the advantages of an open MR imaging system for functional MR imaging
    E van de Giessen
    Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    AJNR Am J Neuroradiol 32:903-7. 2011
    ..The optimal TE was also determined...
  46. ncbi request reprint Demonstration of a reduction in muscarinic receptor binding in early Alzheimer's disease using iodine-123 dexetimide single-photon emission tomography
    J J Claus
    Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands
    Eur J Nucl Med 24:602-8. 1997
    ..Using an MRI-SPET matching technique, we conclude that [123I]4-iododexetimide binding is reduced in patients with mild probable Alzheimer's disease in areas of temporal and temporo-parietal cortex...
  47. ncbi request reprint Memory disturbances in "Ecstasy" users are correlated with an altered brain serotonin neurotransmission
    L Reneman
    Graduate School of Neurosciences, Department of Nuclear Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Psychopharmacology (Berl) 148:322-4. 2000
    ..Since loss of 5-HT neurons has been implicated in memory loss, it is important to establish whether MDMA use may produce changes in postsynaptic 5-HT receptors and memory function in humans...
  48. ncbi request reprint Evaluation of high-resolution pinhole SPECT using a small rotating animal
    J B Habraken
    Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Nucl Med 42:1863-9. 2001
    ..This mechanism permits pinhole SPECT to replace many ex vivo animal experiments...
  49. ncbi request reprint No significant effects of single intravenous, single oral and subchronic oral administration of acetylcholinesterase inhibitors on striatal [123I]FP-CIT binding in rats
    R J J Knol
    Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 15 F2N, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 35:598-604. 2008
    ..The aim of this study was to investigate effects of single intravenous, single oral and subchronic oral administration of AChEIs on DAT availability in the rat brain as measured by [(123)I]FP-CIT...
  50. doi request reprint Serotonin and dopamine transporters in relation to neuropsychological functioning, personality traits and mood in young adult healthy subjects
    S M Burke
    Department of Medical Psychology, VU University Medical Center, Amsterdam, The Netherlands
    Psychol Med 41:419-29. 2011
    ....
  51. ncbi request reprint Effects of psychotherapy on regional cerebral blood flow during trauma imagery in patients with post-traumatic stress disorder: a randomized clinical trial
    R J L Lindauer
    Department of Psychiatry, Academic Medical Centre, Amsterdam, The Netherlands
    Psychol Med 38:543-54. 2008
    ..Functional brain-imaging studies in post-traumatic stress disorder (PTSD) have suggested functional alterations in temporal and prefrontal cortical regions. Effects of psychotherapy on these brain regions have not yet been examined...
  52. ncbi request reprint [Dose-escalation of SSRIS in major depressive disorder. Should not be recommended in current guidelines]
    H G Ruhé
    Universiteit van Amsterdam, Amsterdam
    Tijdschr Psychiatr 52:615-25. 2010
    ..A systematic review of the literature revealed uncertainty about the efficacy of dose escalation and pointed to methodological weaknesses in earlier research...
  53. ncbi request reprint The acute and chronic effects of MDMA ("ecstasy") on cortical 5-HT2A receptors in rat and human brain
    Liesbeth Reneman
    Graduate School of Neurosciences, Department of Nuclear Medicine Academic Medical Center, 1105 AZ Amsterdam, The Netherlands
    Neuropsychopharmacology 26:387-96. 2002
    ..The combined results of this study suggest a compensatory upregulation of post-synaptic 5-HT(2A) receptors in the occipital cortex of ex-MDMA users due to low synaptic 5-HT levels...
  54. ncbi request reprint Use of amphetamine by recreational users of ecstasy (MDMA) is associated with reduced striatal dopamine transporter densities: a [123I]beta-CIT SPECT study--preliminary report
    Liesbeth Reneman
    Department of Nuclear Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Psychopharmacology (Berl) 159:335-40. 2002
    ..However, little is known about the effects of ecstasy use or the combination of ecstasy and amphetamine use on dopamine (DA) neurones in the human brain...
  55. ncbi request reprint Validity of [123I]beta-CIT SPECT in detecting MDMA-induced serotonergic neurotoxicity
    Liesbeth Reneman
    Department of Nuclear Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands
    Synapse 46:199-205. 2002
    ....
  56. ncbi request reprint Subjective experience and D2 receptor occupancy in patients with recent-onset schizophrenia treated with low-dose olanzapine or haloperidol: a randomized, double-blind study
    Lieuwe De Haan
    Academic Medical Center, University of Amsterdam Department of Psychiatry, The Netherlands
    Am J Psychiatry 160:303-9. 2003
    ..In addition, they sought preliminary evidence on whether subjective experience is better with low-dose olanzapine than with low-dose haloperidol...
  57. ncbi request reprint Mood disorders and serotonin transporter density in ecstasy users--the influence of long-term abstention, dose, and gender
    Maartje M L de Win
    Department of Radiology G1 229, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Psychopharmacology (Berl) 173:376-82. 2004
    ..Neurotoxic effects of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") on the serotonin (5-HT) system have been described in animals and humans, but little is known about long-term effects of ecstasy use on mood...
  58. ncbi request reprint Synthesis and evaluation of iodinated TZTP-derivatives as potential radioligands for imaging of muscarinic M2 receptors with SPET
    Remco J J Knol
    Graduate School of Neurosciences, Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Nucl Med Biol 31:111-23. 2004
    ..The usefulness of this tracer in human SPET imaging may therefore be limited...
  59. ncbi request reprint Validity of in vivo [123I]beta-CIT SPECT in detecting MDMA-induced neurotoxicity in rats
    Maartje M L de Win
    Department of Radiology, University of Amsterdam, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Eur Neuropsychopharmacol 14:185-9. 2004
    ..These data show that [(123)I]beta-CIT SPECT may be able to detect MDMA-induced loss of SERTs. Therefore, this may be a promising technique to perform serial studies on MDMA-induced serotonergic neurotoxicity in living small animals...
  60. ncbi request reprint Subjective experience and dopamine D2 receptor occupancy in patients treated with antipsychotics: clinical implications
    Lieuwe De Haan
    Adolescent Clinic, Academic Medical Center, Department of Psychiatry, University of Amsterdam, Amsterdam, The Netherlands
    Can J Psychiatry 49:290-6. 2004
    ..This paper gives an overview of studies on the association between dopaminergic neurotransmission and the subjective experience of patients with schizophrenia...
  61. ncbi request reprint Cerebral blood flow changes during script-driven imagery in police officers with posttraumatic stress disorder
    Ramón J L Lindauer
    Centre for Psychological Trauma, Department of Psychiatry, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Biol Psychiatry 56:853-61. 2004
    ..The aim of this study was to examine the neuronal circuitry underlying responses to script-driven imagery in traumatized police officers with and without PTSD and with low comorbidity rates...
  62. ncbi request reprint Validation of [(123)I]beta-CIT SPECT to assess serotonin transporters in vivo in humans: a double-blind, placebo-controlled, crossover study with the selective serotonin reuptake inhibitor citalopram
    Maartje M L de Win
    Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Neuropsychopharmacology 30:996-1005. 2005
    ..Although we provide some evidence that [(123)I]beta-CIT SPECT may be used to measure SERTs in SERT-low cortical areas, these measurements must be interpreted with caution...
  63. ncbi request reprint Occupancy of dopamine D2 receptors by antipsychotic drugs is related to nicotine addiction in young patients with schizophrenia
    Lieuwe De Haan
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Psychopharmacology (Berl) 183:500-5. 2006
    ..It has been suggested that a low availability of these receptors may increase the risk for addictive behavior...
  64. ncbi request reprint The Netherlands XTC Toxicity (NeXT) study: objectives and methods of a study investigating causality, course, and clinical relevance
    Maartje M L de Win
    Department of Radiology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Int J Methods Psychiatr Res 14:167-85. 2005
    ..The combined results will lead to conclusions that can be used in prevention messages, clinical decision making, and the development of an (inter)national ecstasy policy...
  65. ncbi request reprint No-carrier-added versus carrier-added123I-metaiodobenzylguanidine for the assessment of cardiac sympathetic nerve activity
    Hein J Verberne
    Department of Nuclear Medicine, University of Amsterdam, F2 238, Academic Medical Center, PO Box 22700, 1100 DE, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 33:483-90. 2006
    ..e. uptake-1 mechanism). We evaluated the hypothesis that nca MIBG will be less influenced by changes in extra-neuronal uptake (i.e. uptake-2 mechanism) compared with carrier-added (ca) MIBG...
  66. ncbi request reprint Neuroimaging findings with MDMA/ecstasy: technical aspects, conceptual issues and future prospects
    Liesbeth Reneman
    Graduate School of Neurosciences, Department of Radiology, Academic Medical Centre, University of Amsterdam, The Netherlands
    J Psychopharmacol 20:164-75. 2006
    ..Because most studies have had a retrospective design, in which evidence is indirect and differs in the degree to which any causal links can be implied, longitudinal studies in human ecstasy users are needed to draw definite conclusions...
  67. ncbi request reprint Ecstasy use and self-reported depression, impulsivity, and sensation seeking: a prospective cohort study
    Maartje M L de Win
    Department of Radiology, University of Amsterdam, Academic Medical Center, The Netherlands
    J Psychopharmacol 20:226-35. 2006
    ..However, low level ecstasy use may increase (certain aspects of) sensation seeking...
  68. ncbi request reprint Memory function and serotonin transporter promoter gene polymorphism in ecstasy (MDMA) users
    Liesbeth Reneman
    Graduate School of Neurosciences, Department of Radiology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Psychopharmacol 20:389-99. 2006
    ..No effect of 5-HTTLPR or gender on memory function or MDMA use was observed...
  69. ncbi request reprint A prospective cohort study on sustained effects of low-dose ecstasy use on the brain in new ecstasy users
    Maartje M L de Win
    Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Neuropsychopharmacology 32:458-70. 2007
    ..Additional studies are needed to replicate these findings...
  70. ncbi request reprint Disrupted dopaminergic neurotransmission in 22q11 deletion syndrome
    Erik Boot
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Neuropsychopharmacology 33:1252-8. 2008
    ..Our results suggest that adults with 22q11DS have disrupted dopaminergic neurotransmission, which might explain their susceptibility for psychiatric disorders...
  71. doi request reprint In vitro and ex vivo storage phosphor imaging of short-living radioisotopes
    Remco J J Knol
    Department of Nuclear Medicine, University of Amsterdam, Academic Medical Center, Amsterdam, The Netherlands
    J Neurosci Methods 168:341-57. 2008
    ..In conclusion, phosphor imaging is an attractive alternative for biodistribution studies of short-living radiotracers in small animals...
  72. pmc AMPT-induced monoamine depletion in humans: evaluation of two alternative [123I]IBZM SPECT procedures
    Erik Boot
    Department of Psychiatry, Academic Medical Centre, University of Amsterdam, Meibergdreef 5, 1070 AW Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 35:1350-6. 2008
    ..However, severe side effects due to relatively high doses (4,500 to 8,000 mg) of AMPT have been reasons for study withdrawal. Thus, we assessed the effectiveness and tolerability of two alternative procedures, using lower doses of AMPT...
  73. doi request reprint Cerebral impairment in chronic solvent-induced encephalopathy
    Ieke Visser
    Academic Psychiatric Center AMC, Amsterdam, The Netherlands
    Ann Neurol 63:572-80. 2008
    ..To detect preclinical, solvent-related effects, we also studied the FST circuitry in solvent-exposed, but asymptomatic workers...
  74. doi request reprint Somatostatin receptor scintigraphy in nasopharyngeal carcinoma
    Roelof J Bennink
    Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Clin Nucl Med 33:558-61. 2008
  75. doi request reprint Neurobiological substrates of cue-elicited craving and anhedonia in recently abstinent opioid-dependent males
    Fleur Zijlstra
    Department of Nuclear Medicine, Academic Medical Centre, 1105 AZ, Amsterdam, The Netherlands
    Drug Alcohol Depend 99:183-92. 2009
    ..The neural correlates of cue-induced craving and anhedonia in opioid-dependent patients are, however, not well understood. We studied brain activation patterns following visual presentation of neutral, pleasant and heroin-related cues...
  76. doi request reprint Neurotoxic effects of ecstasy on the thalamus
    Maartje M L de Win
    Department of Radiology, University of Amsterdam, Academic Medical Center, Amsterdam, The Netherlands
    Br J Psychiatry 193:289-96. 2008
    ..Neurotoxic effects of ecstasy have been reported, although it remains unclear whether effects can be attributed to ecstasy, other recreational drugs or a combination of these...
  77. doi request reprint Evidence why paroxetine dose escalation is not effective in major depressive disorder: a randomized controlled trial with assessment of serotonin transporter occupancy
    Henricus G Ruhe
    Program for Mood Disorders, Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Neuropsychopharmacology 34:999-1010. 2009
    ..This is explained by the absence of significant increases of SERT occupancy by paroxetine dose escalation, despite increased paroxetine serum concentrations (ISRCTN44111488)...
  78. doi request reprint Sustained effects of ecstasy on the human brain: a prospective neuroimaging study in novel users
    Maartje M L de Win
    Department of Radiology, University of Amsterdam, Academic Medical Center, Amsterdam, The Netherlands
    Brain 131:2936-45. 2008
    ..Although we do not know yet whether these effects are reversible or not, we cannot exclude that ecstasy even in low doses is neurotoxic to the brain...
  79. doi request reprint Serotonin transporter gene promoter polymorphisms modify the association between paroxetine serotonin transporter occupancy and clinical response in major depressive disorder
    Henricus G Ruhe
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Pharmacogenet Genomics 19:67-76. 2009
    ..In major depressive disorder, selective serotonin reuptake inhibitors target the serotonin transporter (SERT). Their response rates (30-50%) are modified by SERT promotor polymorphisms (5-HTTLPR)...
  80. doi request reprint Striatal dopamine transporter availability associated with polymorphisms in the dopamine transporter gene SLC6A3
    Elisabeth M van de Giessen
    Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Nucl Med 50:45-52. 2009
    ..Other polymorphisms in the DAT gene were not extensively studied. Therefore, we investigated whether polymorphisms in both 3' and 5' ends of the DAT gene show association with in vivo striatal DAT expression...
  81. doi request reprint Serotonin transporter binding with [123I]beta-CIT SPECT in major depressive disorder versus controls: effect of season and gender
    Henricus G Ruhe
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 36:841-9. 2009
    ..We aimed to measure SERT availability and study the effects of age, gender and season of scanning in MDD patients in comparison to healthy controls...
  82. doi request reprint The nicotinic acetylcholine receptor partial agonist varenicline and the treatment of drug dependence: a review
    Cleo L Crunelle
    Amsterdam Institute for Addiction Research and Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Eur Neuropsychopharmacol 20:69-79. 2010
    ..Based on a review of the available literature, we hypothesize a potential role for varenicline in the prevention of relapse in patients recovering from drug dependence other than nicotine dependence...
  83. doi request reprint Dose-dependent and sustained effects of varenicline on dopamine D2/3 receptor availability in rats
    Cleo L Crunelle
    Amsterdam Institute for Addiction Research and Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Eur Neuropsychopharmacol 21:205-10. 2011
    ..These observations suggest that increased DRD2/3 availability may contribute to varenicline's efficacy for smoking cessation and show promise for varenicline as a treatment of other types of drug dependence...
  84. doi request reprint Reduced striatal D2 receptor binding in myoclonus-dystonia
    R J Beukers
    Department of Neurology, Academic Medical Centre, University of Amsterdam, P O Box 22660, 1100 DD, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 36:269-74. 2009
    ..To study striatal dopamine D(2) receptor availability in DYT11 mutation carriers of the autosomal dominantly inherited disorder myoclonus-dystonia (M-D)...
  85. ncbi request reprint Disease-related and drug-induced changes in dopamine transporter expression might undermine the reliability of imaging studies of disease progression in Parkinson's disease
    A Winogrodzka
    Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Parkinsonism Relat Disord 11:475-84. 2005
    ..In this paper we review the evidence on the utility of DAT imaging with SPECT in early PD detection as well as in monitoring neurprotection...
  86. ncbi request reprint Effects of dose, sex, and long-term abstention from use on toxic effects of MDMA (ecstasy) on brain serotonin neurons
    L Reneman
    Departments of Nuclear Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, Netherlands
    Lancet 358:1864-9. 2001
    ..We investigated the effects of moderate and heavy MDMA use, sex differences, and long-term effects of MDMA use on serotonin neurons in different brain regions...
  87. doi request reprint Accuracy and precision of pseudo-continuous arterial spin labeling perfusion during baseline and hypercapnia: a head-to-head comparison with ¹⁵O H₂O positron emission tomography
    D F R Heijtel
    Department of Radiology, Academic Medical Center, Amsterdam, The Netherlands Electronic address
    Neuroimage 92:182-92. 2014
    ..These results pave the way for quantitative usage of pCASL MRI in both clinical and research settings...
  88. ncbi request reprint Movies of dopamine transporter occupancy with ultra-high resolution focusing pinhole SPECT
    B Vastenhouw
    Department of Nuclear Medicine, Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
    Mol Psychiatry 12:984-7. 2007
    ..Applied to the midbrain dopamine system of different models of disease, this will aid the understanding of dynamic processes of this neurotransmitter that underlie brain functions and human brain pathology...
  89. doi request reprint Structural, functional and molecular imaging of the brain in primary focal dystonia--a review
    E Zoons
    Department of Neurology, Academic Medical Centre, Amsterdam, The Netherlands
    Neuroimage 56:1011-20. 2011
    ..Imaging techniques have clearly enhanced current knowledge on the pathophysiology of primary focal dystonia and will continue to do so in the future...
  90. doi request reprint In vivo [(123)I]CNS-1261 binding to D-serine-activated and MK801-blocked NMDA receptors: A storage phosphor imaging study in rats
    Remco J J Knol
    Department of Nuclear Medicine, University of Amsterdam, Academic Medical Center, Amsterdam, The Netherlands
    Synapse 63:557-64. 2009
    ..In conclusion, our study has shown that [(123)I]CNS-1261 binding is influenced by NMDA receptor availability. However, high nonspecific binding limits quantification and small changes in receptor availability are unlikely to be detected...
  91. doi request reprint Brain dopamine and serotonin transporter binding are associated with visual attention bias for food in lean men
    K E Koopman
    Department of Endocrinology and Metabolism, Academic Medical Center Amsterdam, University of Amsterdam, The Netherlands
    Psychol Med 46:1707-17. 2016
    ..We studied the relationship between striatal DA transporters (DAT) and diencephalic 5-HT transporters (SERT), behavioral tasks and questionnaires, and food intake...
  92. pmc Bromocriptine and insulin sensitivity in lean and obese subjects
    L Bähler
    Internal MedicineAcademic Medical Center, Amsterdam, The Netherlands
    Endocr Connect 5:44-52. 2016
    ..In lean subjects, this effect only occurred when bromocriptine was administrated in the evening, whereas in the obese, insulin sensitivity increased independent of the timing of bromocriptine administration...
  93. ncbi request reprint Sepiapterin reductase deficiency an autosomal recessive DOPA-responsive dystonia
    Nico G Abeling
    Academic Medical Center, Laboratory Genetic Metabolic Diseases, University of Amsterdam, Amsterdam, The Netherlands
    Mol Genet Metab 89:116-20. 2006
    ....
  94. ncbi request reprint Idiopathic hyposmia as a preclinical sign of Parkinson's disease
    Mirthe M Ponsen
    Research Institute Neurosciences Vrije Universiteit, Department of Neurology, VU University Medical Center Amsterdam, The Netherlands
    Ann Neurol 56:173-81. 2004
    ..These results indicate that idiopathic olfactory dysfunction is associated with an increased risk of developing PD of at least 10%...
  95. ncbi request reprint Pinhole SPECT imaging of dopamine transporters correlates with dopamine transporter immunohistochemical analysis in the MPTP mouse model of Parkinson's disease
    Gerda Andringa
    Department of Medical Pharmacology, VU University Medical Center, Institute for Clinical and Experimental Neurosciences ICEN, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Neuroimage 26:1150-8. 2005
    ..e., not any protection) effect. Whether this method is also useful for analyzing more subtle effects of neuroprotective treatment (partial protection) remains to be established, by studying mice with small dopaminergic lesions...
  96. ncbi request reprint Comfort, self-confidence, safety, and dopamine D2 receptor occupancy by antipsychotics
    Lieuwe De Haan
    Am J Psychiatry 162:1544-5. 2005
  97. ncbi request reprint Subjective experiences during dopamine depletion
    Lieuwe De Haan
    Am J Psychiatry 162:1755. 2005
  98. ncbi request reprint The role of dopamine in human addiction: from reward to motivated attention
    Ingmar H A Franken
    Institute of Psychology, Erasmus University Rotterdam, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Eur J Pharmacol 526:199-206. 2005
    ..Although there is some preliminary support for the role of dopamine in these attention processes, more studies have to be carried out in order to test the validity of these theories in human subjects...
  99. ncbi request reprint Sensitivity and specificity of dopamine transporter imaging with 123I-FP-CIT SPECT in dementia with Lewy bodies: a phase III, multicentre study
    Ian McKeith
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Lancet Neurol 6:305-13. 2007
    ..Diagnostic accuracy, positive and negative predictive values, and inter-reader agreement were the secondary endpoints and a subgroup of possible DLB patients was also included...
  100. ncbi request reprint Posttraumatic tremor without parkinsonism in a patient with complete contralateral loss of the nigrostriatal pathway
    Jan Zijlmans
    Department of Neurology, The National Institute of Neurology and Neurosurgery, Queen Square, London, United Kingdom
    Mov Disord 17:1086-8. 2002
    ..An explanation, therefore, could be that the lesion in the subthalamic nucleus in our patient prevented the onset of a Parkinson syndrome...
  101. ncbi request reprint Rigidity and bradykinesia reduce interlimb coordination in Parkinsonian gait
    Ania Winogrodzka
    Graduate School of Neurosciences Amsterdam, The Netherlands
    Arch Phys Med Rehabil 86:183-9. 2005
    ..To assess the influence of rigidity and bradykinesia and the extent of dopaminergic degeneration on interlimb coordination during walking in early, drug-naive patients with Parkinsons disease (PD)...