Erik N T P Bakker

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. doi request reprint Blood flow-dependent arterial remodelling is facilitated by inflammation but directed by vascular tone
    Erik N T P Bakker
    Department of Medical Physics, Academic Medical Center, Amsterdam, The Netherlands
    Cardiovasc Res 78:341-8. 2008
  2. ncbi request reprint Remodeling of resistance arteries in organoid culture is modulated by pressure and pressure pulsation and depends on vasomotion
    Erik N T P Bakker
    Dept of Medical Physics, Academic Medical Center, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 286:H2052-6. 2004
  3. ncbi request reprint Activation of resistance arteries with endothelin-1: from vasoconstriction to functional adaptation and remodeling
    Erik N T P Bakker
    Department of Pharmacology, University of Aarhus, Aarhus, Denmark
    J Vasc Res 41:174-82. 2004
  4. ncbi request reprint Small artery remodeling depends on tissue-type transglutaminase
    Erik N T P Bakker
    Department of Medical Physics, Academic Medical Center and Cardiovascular Research Institute Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Circ Res 96:119-26. 2005
  5. doi request reprint Transglutaminases in vascular biology: relevance for vascular remodeling and atherosclerosis
    Erik N T P Bakker
    Department of Medical Physics, Academic Medical Center, Amsterdam, The Netherlands
    J Vasc Res 45:271-8. 2008
  6. ncbi request reprint Flow-dependent remodeling of small arteries in mice deficient for tissue-type transglutaminase: possible compensation by macrophage-derived factor XIII
    Erik N T P Bakker
    Department of Medical Physics, Academic Medical Center and Cardiovascular Research Institute Amsterdam, Amsterdam, The Netherlands
    Circ Res 99:86-92. 2006
  7. ncbi request reprint Small artery remodeling and erythrocyte deformability in L-NAME-induced hypertension: role of transglutaminases
    Adrian Pistea
    Department of Medical Physics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Vasc Res 45:10-8. 2008
  8. doi request reprint Transglutaminase activity regulates atherosclerotic plaque composition at locations exposed to oscillatory shear stress
    Hanke L Matlung
    Department of Biomedical Engineering and Physics, Academic Medical Center, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Atherosclerosis 224:355-62. 2012
  9. ncbi request reprint Calcium channel blockade prevents pressure-dependent inward remodeling in isolated subendocardial resistance vessels
    Oana Sorop
    Department of Medical Physics, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 291:H1236-45. 2006
  10. doi request reprint Nuclear receptor Nur77 inhibits vascular outward remodelling and reduces macrophage accumulation and matrix metalloproteinase levels
    Peter I Bonta
    Department of Medical Biochemistry, Academic Medical Center K1 113, University of Amsterdam, Meibergdreef 15, Amsterdam 1105 AZ, The Netherlands
    Cardiovasc Res 87:561-8. 2010

Collaborators

Detail Information

Publications38

  1. doi request reprint Blood flow-dependent arterial remodelling is facilitated by inflammation but directed by vascular tone
    Erik N T P Bakker
    Department of Medical Physics, Academic Medical Center, Amsterdam, The Netherlands
    Cardiovasc Res 78:341-8. 2008
    ..We tested the hypothesis that inflammation facilitates the remodelling response, but that vascular tone determines its direction (inward or outward)...
  2. ncbi request reprint Remodeling of resistance arteries in organoid culture is modulated by pressure and pressure pulsation and depends on vasomotion
    Erik N T P Bakker
    Dept of Medical Physics, Academic Medical Center, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 286:H2052-6. 2004
    ..In conclusion, these results indicate that remodeling is not enhanced by high pressure. Pressure pulsation causes partial dilation and reduces inward remodeling. The appearance of vasomotion is associated with enhanced inward remodeling...
  3. ncbi request reprint Activation of resistance arteries with endothelin-1: from vasoconstriction to functional adaptation and remodeling
    Erik N T P Bakker
    Department of Pharmacology, University of Aarhus, Aarhus, Denmark
    J Vasc Res 41:174-82. 2004
    ..5 to 68 +/- 1.5% of the initial gel diameter. In conclusion, these data show that inward eutrophic remodeling is a response to sustained contraction, which may involve collagen reorganization through beta(3)-integrins...
  4. ncbi request reprint Small artery remodeling depends on tissue-type transglutaminase
    Erik N T P Bakker
    Department of Medical Physics, Academic Medical Center and Cardiovascular Research Institute Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Circ Res 96:119-26. 2005
    ..This mechanism may reveal a novel therapeutic target for pathologies associated with inward remodeling of the resistance arteries...
  5. doi request reprint Transglutaminases in vascular biology: relevance for vascular remodeling and atherosclerosis
    Erik N T P Bakker
    Department of Medical Physics, Academic Medical Center, Amsterdam, The Netherlands
    J Vasc Res 45:271-8. 2008
    ..However, recent data suggest that Tgases play a role in several other processes in vascular biology. These newly discovered areas include endothelial barrier function, small artery remodeling, and atherosclerosis...
  6. ncbi request reprint Flow-dependent remodeling of small arteries in mice deficient for tissue-type transglutaminase: possible compensation by macrophage-derived factor XIII
    Erik N T P Bakker
    Department of Medical Physics, Academic Medical Center and Cardiovascular Research Institute Amsterdam, Amsterdam, The Netherlands
    Circ Res 99:86-92. 2006
    ..Adventitial monocytes/macrophages are a source of factor XIII in tTG-null mice and contribute to an alternative, delayed mechanism of inward remodeling when tTG is absent...
  7. ncbi request reprint Small artery remodeling and erythrocyte deformability in L-NAME-induced hypertension: role of transglutaminases
    Adrian Pistea
    Department of Medical Physics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Vasc Res 45:10-8. 2008
    ..We hypothesized that these alterations depend on transglutaminases, cross-linking enzymes present in the vascular wall, monocytes/macrophages and erythrocytes...
  8. doi request reprint Transglutaminase activity regulates atherosclerotic plaque composition at locations exposed to oscillatory shear stress
    Hanke L Matlung
    Department of Biomedical Engineering and Physics, Academic Medical Center, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Atherosclerosis 224:355-62. 2012
    ..Atherosclerosis preferentially develops at sites of disturbed blood flow. We tested the hypothesis that transglutaminase activity plays a role in plaque development at these locations...
  9. ncbi request reprint Calcium channel blockade prevents pressure-dependent inward remodeling in isolated subendocardial resistance vessels
    Oana Sorop
    Department of Medical Physics, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 291:H1236-45. 2006
    ..Although microvascular pressure profiles distal to stenoses are poorly defined, these data suggest that vasodilator therapy could improve subendocardial microvascular function and structure in coronary artery disease...
  10. doi request reprint Nuclear receptor Nur77 inhibits vascular outward remodelling and reduces macrophage accumulation and matrix metalloproteinase levels
    Peter I Bonta
    Department of Medical Biochemistry, Academic Medical Center K1 113, University of Amsterdam, Meibergdreef 15, Amsterdam 1105 AZ, The Netherlands
    Cardiovasc Res 87:561-8. 2010
    ..Detailed knowledge on the mechanism underlying this vascular response is limited, and we aimed to study the function of Nur77 in smooth muscle cells (SMCs) in arterial remodelling...
  11. doi request reprint Testosterone and β-oestradiol prevent inward remodelling of rat small mesenteric arteries: role of NO and transglutaminase
    Lara del Campo
    Department of Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, The Netherlands
    Clin Sci (Lond) 124:719-28. 2013
    ..Inward remodelling, both in males and females, depends on NO and TG activity. In females, inhibition of inward remodelling could be mediated by NO-mediated inhibition of TG activity...
  12. ncbi request reprint Inward remodeling follows chronic vasoconstriction in isolated resistance arteries
    Erik N T P Bakker
    Academic Medical Center, University of Amsterdam, Department of Medical Physics and Cardiovascular Research, Institute Amsterdam CRIA, The Netherlands
    J Vasc Res 39:12-20. 2002
    ..These data show that a persistent active reduction in lumen diameter is followed by inward remodeling of arterioles...
  13. doi request reprint Strain-dependent susceptibility for hypertension in mice resides in the natural killer gene complex
    Zhila Taherzadeh
    Dept of Biomedical Engineering and Physics, Academic Medical Ctr, Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 298:H1273-82. 2010
    ..In conclusion, we have identified the NK gene complex as an important determinant in the genetically determined sensitivity to develop l-NAME-induced hypertension in mice...
  14. doi request reprint Smooth muscle contractile plasticity in rat mesenteric small arteries: sensitivity to specific vasoconstrictors, distension and inflammatory cytokines
    Bilge Guvenc Tuna
    Department of Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Vasc Res 50:249-62. 2013
    ....
  15. doi request reprint Activation of extracellular transglutaminase 2 by mechanical force in the arterial wall
    Guizela Huelsz-Prince
    Department of Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, The Netherlands
    J Vasc Res 50:383-95. 2013
    ....
  16. ncbi request reprint Flow inhibits inward remodeling in cannulated porcine small coronary arteries
    Adrian Pistea
    Department of Medical Physics, Academic Medical Center, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 289:H2632-40. 2005
    ..Vessels cultured under flow conditions remained more dilated when NO synthesis was blocked. Inward remodeling occurred in vessels cultured under no-flow conditions and was inhibited by flow-dependent NO synthesis...
  17. doi request reprint Small artery remodeling: current concepts and questions
    Jeroen van den Akker
    Department of Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Vasc Res 47:183-202. 2010
    ....
  18. doi request reprint Role of transglutaminases in cuff-induced atherosclerotic lesion formation in femoral arteries of ApoE3 Leiden mice
    Hanke L Matlung
    Department of Biomedical Engineering and Physics, Academic Medical Center, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Atherosclerosis 213:77-84. 2010
    ..In this study we investigate the influence of combined inhibition of both tissue-type transglutaminase (TG2) and the plasma transglutaminase FXIIIA on early lesion development...
  19. doi request reprint Relation between active and passive biomechanics of small mesenteric arteries during remodeling
    Bilge Guvenc Tuna
    Department of Biomedical Engineering and Physics, Academic Medical Center, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    J Biomech 46:1420-6. 2013
    ....
  20. doi request reprint Smooth muscle biomechanics and plasticity: relevance for vascular calibre and remodelling
    Bilge Guvenc Tuna
    Department of Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Basic Clin Pharmacol Toxicol 110:35-41. 2012
    ..This may contribute to structural inward remodelling as seen in hypertension and flow reduction...
  21. pmc Decomposition cross-correlation for analysis of collagen matrix deformation by single smooth muscle cells
    Jeroen van den Akker
    Department of Medical Physics, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Med Biol Eng Comput 46:443-50. 2008
    ..Thus, the current setup offers a tool to systematically study different components active in matrix remodeling...
  22. pmc The redox state of transglutaminase 2 controls arterial remodeling
    Jeroen van den Akker
    Department of Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 6:e23067. 2011
    ..In conclusion, these results show that a reduced state induces smooth muscle membrane-bound TG2 activity. Inward remodeling results from the cross-linking of vicinal matrix proteins, causing a stiffening of the arterial wall...
  23. pmc Vascular smooth muscle cells remodel collagen matrices by long-distance action and anisotropic interaction
    Jeroen van den Akker
    Department of Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Med Biol Eng Comput 50:701-15. 2012
    ..This process could add to the 3D organization and remodeling of blood vessels based on the orientation and contraction of SMCs...
  24. ncbi request reprint Mechanics of microvascular remodeling
    Ed Vanbavel
    Department of Medical Physics, Academic Medical Center, University of Amsterdam, The Netherlands
    Clin Hemorheol Microcirc 34:35-41. 2006
    ..Finally, the role of transglutaminases in remodeling is described...
  25. doi request reprint Shear stress, reactive oxygen species, and arterial structure and function
    Hanke L Matlung
    Department of Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Antioxid Redox Signal 11:1699-709. 2009
    ..We conclude that future work should address the role of H(2)O(2) as an endothelium-derived factor mediating tone and influencing structure of small arteries over the long term...
  26. pmc Gene Expression and MicroRNA Expression Analysis in Small Arteries of Spontaneously Hypertensive Rats. Evidence for ER Stress
    Teresa Palao
    Department of Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, The Netherlands
    PLoS ONE 10:e0137027. 2015
    ..The most prominent of these, Thbs4, is related to vascular ER stress that is associated with hypertension. ..
  27. doi request reprint Thrombospondin-4 knockout in hypertension protects small-artery endothelial function but induces aortic aneurysms
    Teresa Palao
    Departments of Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 310:H1486-93. 2016
    ..We conclude that TSP-4 plays a role in hypertension, affecting cardiac hypertrophy, aortic aneurysm formation, as well as endothelial-dependent relaxation in resistance arteries. ..
  28. pmc Heterogeneity in arterial remodeling among sublines of spontaneously hypertensive rats
    Erik N T P Bakker
    Department of Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, The Netherlands
    PLoS ONE 9:e107998. 2014
    ..We tested the hypothesis that the pathophysiology of vascular remodeling in hypertension differs among rat sublines...
  29. pmc Calcification locates to transglutaminases in advanced human atherosclerotic lesions
    Hanke L Matlung
    Department of Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, The Netherlands
    Am J Pathol 175:1374-9. 2009
    ..These results are consistent with the hypothesis that transglutaminases participate in the calcification process of human atherosclerotic arteries...
  30. pmc TR3 nuclear orphan receptor prevents cyclic stretch-induced proliferation of venous smooth muscle cells
    Vivian De Waard
    Department of Medical Biochemistry, Academic Medical Center, K1 116, Meibergdreef 15, 1105 AZ Amsterdam
    Am J Pathol 168:2027-35. 2006
    ..In conclusion, TR3 represents inhibitory mechanisms to restrict venous SMC proliferation and may contribute to prevention of vein-graft disease...
  31. pmc Transglutaminase 2 is secreted from smooth muscle cells by transamidation-dependent microparticle formation
    Jeroen van den Akker
    Departmentt of Biomedical Engineering and Physics, Academic Medical Center L0 120, University of Amsterdam, PO Box 22660, 1100 DD, Amsterdam, The Netherlands
    Amino Acids 42:961-73. 2012
    ..In conclusion, the current data suggest that TG2 is secreted from the cell via microparticles through a process regulated by TG2 cross-linking...
  32. pmc Clearance from the mouse brain by convection of interstitial fluid towards the ventricular system
    Beatrice Bedussi
    Department of Biomedical Engineering and Physics, Academic Medical Center, Room L0 119 Meibergdreef 9, PO Box 22660, 1105 AZ, Amsterdam, The Netherlands
    Fluids Barriers CNS 12:23. 2015
    ..Suggested mechanisms for clearance implicate a role for brain interstitial and cerebrospinal fluids. However, the proposed direction of flow, the anatomical structures involved, and the driving forces are controversial...
  33. doi request reprint Tissue transglutaminase activity is involved in the differentiation of oligodendrocyte precursor cells into myelin-forming oligodendrocytes during CNS remyelination
    Miriam E van Strien
    VU University Medical Center, Neuroscience Campus Amsterdam, Department of Anatomy and Neurosciences, Amsterdam, The Netherlands
    Glia 59:1622-34. 2011
    ..Therefore, manipulating TG2 activity may represent an interesting new target for remyelination in demyelinating diseases...
  34. pmc Lymphatic Clearance of the Brain: Perivascular, Paravascular and Significance for Neurodegenerative Diseases
    Erik N T P Bakker
    Department of Biomedical Engineering and Physics, Academic Medical Center, 1105 AZ, Amsterdam, The Netherlands
    Cell Mol Neurobiol 36:181-94. 2016
    ..The different views on the possible routes for ISF drainage of the brain are discussed in the context of pathological significance. ..
  35. doi request reprint Tissue transglutaminase in Alzheimer's disease: involvement in pathogenesis and its potential as a therapeutic target
    Micha M M Wilhelmus
    Department of Anatomy and Neurosciences, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands
    J Alzheimers Dis 42:S289-303. 2014
    ..Here, we review these data on the role of tTG in the initiation and development of protein aggregates in AD, and discuss the possibility to use inhibitors of the cross-linking activity of tTG as a new therapeutic approach for AD. ..
  36. doi request reprint A vascular bone collector: arterial calcification requires tissue-type transglutaminase
    Ed Vanbavel
    Circ Res 102:507-9. 2008
  37. ncbi request reprint Downregulation of bone morphogenetic protein 4 expression in coronary arterial endothelial cells: role of shear stress and the cAMP/protein kinase A pathway
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
    Arterioscler Thromb Vasc Biol 27:776-82. 2007
    ..Recent studies suggested that atheroprotective levels of shear stress control endothelial BMP-4 expression; however, the underlying mechanisms remained unknown...
  38. doi request reprint MBEC special issue on microcirculation "engineering principles of vascular networks"
    Axel R Pries
    Med Biol Eng Comput 46:407-9. 2008