Kasia Stepniewska

Summary

Affiliation: Mahidol University
Country: Thailand

Publications

  1. pmc An open-label crossover study to evaluate potential pharmacokinetic interactions between oral oseltamivir and intravenous zanamivir in healthy Thai adults
    Sasithon Pukrittayakamee
    Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Rd, Bangkok 10400, Thailand
    Antimicrob Agents Chemother 55:4050-7. 2011
  2. pmc Prognostic indicators in adults hospitalized with falciparum malaria in Western Thailand
    Paul N Newton
    Lao Oxford Mahosot Hospital Wellcome Trust Research Unit, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR
    Malar J 12:229. 2013
  3. pmc Studying the effectiveness of activated carbon R95 respirators in reducing the inhalation of combustion by-products in Hanoi, Vietnam: a demonstration study
    Heiman F L Wertheim
    Oxford University Clinical Research Unit and Wellcome Trust Major Overseas Programme, Hanoi, Vietnam
    Environ Health 11:72. 2012
  4. pmc Comparability of tympanic and oral mercury thermometers at high ambient temperatures
    Amy L Chue
    Shoklo Malaria Research Unit, Mae Sot, Tak, Thailand
    BMC Res Notes 5:356. 2012
  5. pmc Poor quality vital anti-malarials in Africa - an urgent neglected public health priority
    Paul N Newton
    Wellcome Trust Mahosot Hospital Oxford University Tropical Medicine Research Collaboration, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR
    Malar J 10:352. 2011
  6. pmc World Antimalarial Resistance Network I: clinical efficacy of antimalarial drugs
    Ric N Price
    International Health Program, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia
    Malar J 6:119. 2007
  7. pmc Population pharmacokinetics of artesunate and amodiaquine in African children
    Kasia Stepniewska
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    Malar J 8:200. 2009
  8. pmc Some considerations in the design and interpretation of antimalarial drug trials in uncomplicated falciparum malaria
    Kasia Stepniewska
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    Malar J 5:127. 2006
  9. pmc Overestimating resistance in field testing of malaria parasites: simple methods for estimating high EC50 values using a Bayesian approach
    Kasia Stepniewska
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    Malar J 6:4. 2007
  10. pmc Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity
    Kasia Stepniewska
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    Malar J 7:249. 2008

Detail Information

Publications47

  1. pmc An open-label crossover study to evaluate potential pharmacokinetic interactions between oral oseltamivir and intravenous zanamivir in healthy Thai adults
    Sasithon Pukrittayakamee
    Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Rd, Bangkok 10400, Thailand
    Antimicrob Agents Chemother 55:4050-7. 2011
    ..720, P = 0.002, n = 16) but not with the oseltamivir AUC (r(p) = 0.121, n = 16). There is no clinically significant pharmacokinetic interaction between oseltamivir and zanamivir...
  2. pmc Prognostic indicators in adults hospitalized with falciparum malaria in Western Thailand
    Paul N Newton
    Lao Oxford Mahosot Hospital Wellcome Trust Research Unit, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR
    Malar J 12:229. 2013
    ..Severe malaria remains a major cause of death and morbidity amongst adults in the Asiatic tropics...
  3. pmc Studying the effectiveness of activated carbon R95 respirators in reducing the inhalation of combustion by-products in Hanoi, Vietnam: a demonstration study
    Heiman F L Wertheim
    Oxford University Clinical Research Unit and Wellcome Trust Major Overseas Programme, Hanoi, Vietnam
    Environ Health 11:72. 2012
    ..In this demonstration study we set out to establish methods to assess whether wearing an R95 activated carbon respirator could reduce intake of polycyclic aromatic hydrocarbons (PAH) in street workers in Hanoi, Vietnam...
  4. pmc Comparability of tympanic and oral mercury thermometers at high ambient temperatures
    Amy L Chue
    Shoklo Malaria Research Unit, Mae Sot, Tak, Thailand
    BMC Res Notes 5:356. 2012
    ..Body temperature can be measured in seconds with tympanic thermometers as opposed to minutes with mercury ones. The aim of this study was to compare tympanic and oral mercury thermometer measurements under high ambient field temperatures...
  5. pmc Poor quality vital anti-malarials in Africa - an urgent neglected public health priority
    Paul N Newton
    Wellcome Trust Mahosot Hospital Oxford University Tropical Medicine Research Collaboration, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR
    Malar J 10:352. 2011
    ..A vital component of malaria control rests on the availability of good quality artemisinin-derivative based combination therapy (ACT) at the correct dose. However, there are increasing reports of poor quality anti-malarials in Africa...
  6. pmc World Antimalarial Resistance Network I: clinical efficacy of antimalarial drugs
    Ric N Price
    International Health Program, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia
    Malar J 6:119. 2007
    ..This resource will help guide rational drug policies that optimize antimalarial drug use, in the hope that the emergence and spread of resistance to new drugs can be, if not prevented, at least delayed...
  7. pmc Population pharmacokinetics of artesunate and amodiaquine in African children
    Kasia Stepniewska
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    Malar J 8:200. 2009
    ..The aim of this study was to evaluate the PK properties of a newly developed and registered fixed dose combination (FDC) of artesunate and amodiaquine...
  8. pmc Some considerations in the design and interpretation of antimalarial drug trials in uncomplicated falciparum malaria
    Kasia Stepniewska
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    Malar J 5:127. 2006
    ....
  9. pmc Overestimating resistance in field testing of malaria parasites: simple methods for estimating high EC50 values using a Bayesian approach
    Kasia Stepniewska
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    Malar J 6:4. 2007
    ..If isolates cannot be stored for re-testing, more accurate estimations of the degree of resistance can be obtained using a Bayesian approach to data analysis which is described here...
  10. pmc Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity
    Kasia Stepniewska
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    Malar J 7:249. 2008
    ..The aim of this study was to identify and compare factors associated with Plasmodium falciparum gametocyte carriage in three regions of differing malaria endemicity...
  11. pmc In vivo parasitological measures of artemisinin susceptibility
    Kasia Stepniewska
    Mahidol Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand
    J Infect Dis 201:570-9. 2010
    ....
  12. pmc Entomological determinants of insecticide-treated bed net effectiveness in Western Myanmar
    Frank M Smithuis
    Mahidol Oxford Tropical Medicine Research Unit MORU, Mahidol University, Faculty of Tropical Medicine, 3rd Floor, 60th Anniversary Chalermprakiat Building, 420 6 Rajvithi Rd, Ratchathewi District, Bangkok 10400, Thailand
    Malar J 12:364. 2013
    ..A coincident entomological investigation measured malaria vector abundance and biting behaviour and the human population sleeping habits, factors relevant to ITN effectiveness...
  13. pmc The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria
    Sue J Lee
    Mahidol Oxford Tropical Medicine Research Unit MORU, Mahidol University, Faculty of Tropical Medicine, 3rd Floor, 60th Anniversary Chalermprakiat Building, 420 6 Ratchawithi Rd, Ratchathewi District, Bangkok 10400, Thailand
    Malar J 7:149. 2008
    ..Anaemia is assessed either by measurement of the haematocrit or the haemoglobin concentration. For comparisons across studies, it is often necessary to derive one measure from the other...
  14. pmc Effect of high-dose or split-dose artesunate on parasite clearance in artemisinin-resistant falciparum malaria
    Debashish Das
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Clin Infect Dis 56:e48-58. 2013
    ..We investigated whether increasing or splitting the dose of the short-half-life drug artesunate improves parasite clearance in falciparum malaria in the 2 regions...
  15. pmc Hyperparasitaemia and low dosing are an important source of anti-malarial drug resistance
    Nicholas J White
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    Malar J 8:253. 2009
    ..The importance of anti-malarial treatment dosing has been underappreciated. Treatment recommendations are often for the lowest doses that produce "satisfactory" results...
  16. doi request reprint Chloroquine pharmacokinetics in pregnant and nonpregnant women with vivax malaria
    Sue Jean Lee
    Mahidol Oxford Tropical Medicine Research Unit, MORU, Mahidol University, Bangkok, Thailand
    Eur J Clin Pharmacol 64:987-92. 2008
    ..We compared the pharmacokinetics of chloroquine in pregnant and nonpregnant women treated for Plasmodium vivax malaria...
  17. doi request reprint Simplified antimalarial therapeutic monitoring: using the day-7 drug level?
    Nicholas J White
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    Trends Parasitol 24:159-63. 2008
    ..Measurement of the day-7 drug level should be considered as a routine part of antimalarial drug trials...
  18. pmc In vivo assessment of drug efficacy against Plasmodium falciparum malaria: duration of follow-up
    Kasia Stepniewska
    Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Rd, Bangkok 10400, Thailand
    Antimicrob Agents Chemother 48:4271-80. 2004
    ..94) or if the entomological inoculation rate was known. In the assessment of drug efficacy against falciparum malaria, 28 days should be the minimum period of follow-up...
  19. pmc Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study
    Aung Pyae Phyo
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Lancet 379:1960-6. 2012
    ..We aimed to establish whether artemisinin resistance has spread or emerged on the Thailand-Myanmar (Burma) border...
  20. pmc Population pharmacokinetics of lumefantrine in pregnant women treated with artemether-lumefantrine for uncomplicated Plasmodium falciparum malaria
    Joel Tarning
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Antimicrob Agents Chemother 53:3837-46. 2009
    ..In conclusion, altered pharmacokinetic properties of lumefantrine contribute to the high rates of failure of artemether-lumefantrine treatment in later pregnancy. Dose optimization is urgently needed...
  21. ncbi request reprint Effects of different antimalarial drugs on gametocyte carriage in P. vivax malaria
    Sasithon Pukrittayakamee
    Department of Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 79:378-84. 2008
    ..4% versus 14.1%, P = 0.002). Sexual stage activities corresponded with asexual stage activity for all tested regimens. Treatment with potent antimalarial drugs reduces the transmission potential of P. vivax...
  22. ncbi request reprint Haematinic treatment of anaemia increases the risk of Plasmodium vivax malaria in pregnancy
    Mathieu Nacher
    Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    Trans R Soc Trop Med Hyg 97:273-6. 2003
    ..vivax malaria. In P. vivax-endemic areas, systematic iron and folate supplementation confers both benefit and risk in pregnancy...
  23. pmc Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial
    Arjen M Dondorp
    Mahidol Oxford Tropical Medicine Research Unit MORU, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Lancet 376:1647-57. 2010
    ..We compared parenteral treatment with either artesunate or quinine in African children with severe malaria...
  24. ncbi request reprint Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial
    Arjen Dondorp
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    Lancet 366:717-25. 2005
    ..In the treatment of severe malaria, intravenous artesunate is more rapidly acting than intravenous quinine in terms of parasite clearance, is safer, and is simpler to administer, but whether it can reduce mortality is uncertain...
  25. ncbi request reprint Risk factors for recurrent melioidosis in northeast Thailand
    Direk Limmathurotsakul
    Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand
    Clin Infect Dis 43:979-86. 2006
    ..A recent study revealed that 25% of patients with recurrence had reinfection rather than a relapse resulting from a failure to cure. The aim of this study was to reevaluate these 2 patient groups to define their individual risk factors...
  26. pmc Defining the in vivo phenotype of artemisinin-resistant falciparum malaria: a modelling approach
    Lisa J White
    Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS Med 12:e1001823. 2015
    ..We here explore the parasite clearance distributions in an area of artemisinin resistance with the aim refining the in vivo phenotypic definitions...
  27. ncbi request reprint An ultrastructural study of the brain in fatal Plasmodium falciparum malaria
    Emsri Pongponratn
    Department of Tropical Pathology, and Wellcome Trust Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 69:345-59. 2003
    ..7) than in NCM patients (median = 6.9) (P = 0.042). The degree of sequestration of P. falciparum-infected erythrocytes in cerebral microvessels is quantitatively associated with pre-mortem coma...
  28. pmc A phase III, randomized, non-inferiority trial to assess the efficacy and safety of dihydroartemisinin-piperaquine in comparison with artesunate-mefloquine in patients with uncomplicated Plasmodium falciparum malaria in southern Laos
    Mayfong Mayxay
    Wellcome Trust, Mahosot Hospital, Oxford University Tropical Medicine Research Collaboration, Mahosot Hospital, Vientiane, Laos
    Am J Trop Med Hyg 83:1221-9. 2010
    ..falciparum malaria in Laos and is associated with fewer adverse effects. The results of this study were similar to those of the larger multicentre study...
  29. ncbi request reprint Pharmacokinetic study of artemether-lumefantrine given once daily for the treatment of uncomplicated multidrug-resistant falciparum malaria
    Elizabeth A Ashley
    Shoklo Malaria Research Unit, Mae Sot, Thailand
    Trop Med Int Health 12:201-8. 2007
    ..If the fixed antimalarial drug combination artemether-lumefantrine (AL) could be given once daily, this should improve adherence and thus effectiveness and lower the risk of selecting for resistance...
  30. ncbi request reprint How much fat is necessary to optimize lumefantrine oral bioavailability?
    Elizabeth A Ashley
    Shoklo Malaria Research Unit, Mae Sot, Thailand
    Trop Med Int Health 12:195-200. 2007
    ..The aim of this study was to describe the dose-response relationship between coadministration of fat and relative lumefantrine bioavailability, in order to determine the minimum amount of fat necessary to optimize absorption...
  31. pmc Population pharmacokinetic assessment of a new regimen of mefloquine used in combination treatment of uncomplicated falciparum malaria
    Elizabeth A Ashley
    Shoklo Malaria Research Unit, P O Box 46, Mae Sot, Tak 63110, Thailand
    Antimicrob Agents Chemother 50:2281-5. 2006
    ..This new regimen is well tolerated and results in an equivalent therapeutic response...
  32. pmc Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria
    Nicholas J White
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 13:483. 2014
    ..In choosing doses of transmission-blocking drugs there is no substitute yet for mosquito-feeding studies. ..
  33. ncbi request reprint Two randomized controlled trials of ceftazidime alone versus ceftazidime in combination with trimethoprim-sulfamethoxazole for the treatment of severe melioidosis
    Wirongrong Chierakul
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Clin Infect Dis 41:1105-13. 2005
    ..It is not known whether TMP-SMX provides an additional benefit...
  34. pmc The effect of insecticide-treated bed nets on the incidence and prevalence of malaria in children in an area of unstable seasonal transmission in western Myanmar
    Frank M Smithuis
    Mahidol Oxford Tropical Medicine Research Unit MORU, Faculty of Tropical Medicine, Mahidol University, 3rd Floor, 60th Anniversary Chalermprakiat Building, 420 6 Rajvithi Rd, Ratchathewi District, Bangkok 10400, Thailand
    Malar J 12:363. 2013
    ..This study's objective was to evaluate the malaria protective efficacy of village-wide usage of ITN in Western Myanmar and estimate the cost-effectiveness of ITN compared with extending early diagnosis and treatment services...
  35. ncbi request reprint The effects of Plasmodium falciparum and P. vivax infections on placental histopathology in an area of low malaria transmission
    Rose McGready
    Shoklo Malaria Research Unit, Mae Sot, Thailand
    Am J Trop Med Hyg 70:398-407. 2004
    ..These findings emphasize the importance of treating malaria in pregnancy promptly with effective antimalarial drugs...
  36. ncbi request reprint Dihydroartemisinin-piperaquine against multidrug-resistant Plasmodium falciparum malaria in Vietnam: randomised clinical trial
    Tinh Hien Tran
    Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam
    Lancet 363:18-22. 2004
    ..There is general acceptance that to combat resistance, combinations of antimalarial drugs that include an artemisinin derivative should be used, and, if possible, these should be formulated in a single tablet...
  37. pmc Open-label randomized trial of oral trimethoprim-sulfamethoxazole, doxycycline, and chloramphenicol compared with trimethoprim-sulfamethoxazole and doxycycline for maintenance therapy of melioidosis
    Wipada Chaowagul
    Medical Department, Sappasithiprasong Hospital, Ubon Ratchathani, Thailand
    Antimicrob Agents Chemother 49:4020-5. 2005
    ..7-fold increase of relapse or death. A combination of TMP-SMX and doxycycline is as effective as and better tolerated than the conventional four-drug regimen for the oral treatment phase of melioidosis...
  38. ncbi request reprint The influence of HIV infection on clinical presentation, response to treatment, and outcome in adults with Tuberculous meningitis
    Guy E Thwaites
    Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam
    J Infect Dis 192:2134-41. 2005
    ..Tuberculous meningitis occurs more commonly in human immunodeficiency virus (HIV)-infected individuals than in HIV-uninfected individuals, but whether HIV infection alters the presentation and outcome of tuberculous meningitis is unknown...
  39. ncbi request reprint An open label randomized comparison of mefloquine-artesunate as separate tablets vs. a new co-formulated combination for the treatment of uncomplicated multidrug-resistant falciparum malaria in Thailand
    Elizabeth A Ashley
    Shoklo Malaria Research Unit, Tak, Thailand
    Trop Med Int Health 11:1653-60. 2006
    ..A new fixed combination of mefloquine plus artesunate has been developed. This was compared with the conventional regimen of separate tablets for the treatment of uncomplicated multidrug-resistant falciparum malaria...
  40. ncbi request reprint The pharmacokinetics of artemether and lumefantrine in pregnant women with uncomplicated falciparum malaria
    Rose McGready
    Shoklo Malaria Research Unit, P O Box 46, Mae Sot, Tak, Thailand
    Eur J Clin Pharmacol 62:1021-31. 2006
    ..To determine the pharmacokinetic properties of artemether and lumefantrine (AL) in pregnant women with recrudescent uncomplicated multi-drug resistant falciparum malaria...
  41. ncbi request reprint Efficacy and effectiveness of dihydroartemisinin-piperaquine versus artesunate-mefloquine in falciparum malaria: an open-label randomised comparison
    Frank Smithuis
    Medecins Sans Frontieres Holland, Yangon, Myanmar
    Lancet 367:2075-85. 2006
    ....
  42. ncbi request reprint Dexamethasone for the treatment of tuberculous meningitis in adolescents and adults
    Guy E Thwaites
    Oxford University Clinical Research Unit at the Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    N Engl J Med 351:1741-51. 2004
    ....
  43. ncbi request reprint Effect of antituberculosis drug resistance on response to treatment and outcome in adults with tuberculous meningitis
    Guy E Thwaites
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    J Infect Dis 192:79-88. 2005
    ..Tuberculous meningitis (TBM) caused by Mycobacterium tuberculosis resistant to 1 or more antituberculosis drugs is an increasingly common clinical problem, although the impact on outcome is uncertain...
  44. pmc Evaluation of the Wayson stain for the rapid diagnosis of melioidosis
    Elizabeth A Sheridan
    J Clin Microbiol 45:1669-70. 2007
  45. ncbi request reprint Dexamethasone in Vietnamese adolescents and adults with bacterial meningitis
    Thi Hoang Mai Nguyen
    Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    N Engl J Med 357:2431-40. 2007
    ..It is uncertain whether all adults with bacterial meningitis benefit from treatment with adjunctive dexamethasone...
  46. ncbi request reprint Validation of a diagnostic algorithm for adult tuberculous meningitis
    M Estee Torok
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam
    Am J Trop Med Hyg 77:555-9. 2007
    ..Validation in an HIV-endemic setting is required...
  47. pmc A multi-center randomised controlled trial of gatifloxacin versus azithromycin for the treatment of uncomplicated typhoid fever in children and adults in Vietnam
    Christiane Dolecek
    Oxford University Clinical Research Unit, The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    PLoS ONE 3:e2188. 2008
    ..Drug resistant typhoid fever is a major clinical problem globally. Many of the first line antibiotics, including the older generation fluoroquinolones, ciprofloxacin and ofloxacin, are failing...