P Singhasivanon

Summary

Affiliation: Mahidol University
Country: Thailand

Publications

  1. pmc Artemisinin resistance containment project in Thailand. (I): Implementation of electronic-based malaria information system for early case detection and individual case management in provinces along the Thai-Cambodian border
    Amnat Khamsiriwatchara
    Center of Excellence for Biomedical and Public Health Informatics BIOPHICS, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 11:247. 2012
  2. pmc Artemisinin resistance containment project in Thailand. II: Responses to mefloquine-artesunate combination therapy among falciparum malaria patients in provinces bordering Cambodia
    Wichai Satimai
    Center of Excellence for Biomedical and Public Health Informatics BIOPHICS, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 11:300. 2012
  3. pmc An analysis of health system resources in relation to pandemic response capacity in the Greater Mekong Subregion
    Piya Hanvoravongchai
    Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    Int J Health Geogr 11:53. 2012
  4. pmc Chloroquine resistant vivax malaria in a pregnant woman on the western border of Thailand
    Marcus J Rijken
    Shoklo Malaria Research Unit, PO Box 46 Mae Sot, Tak 63110, Thailand
    Malar J 10:113. 2011
  5. pmc Spatio-temporal patterns of malaria infection in Bhutan: a country embarking on malaria elimination
    Kinley Wangdi
    Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 10:89. 2011
  6. pmc Development of temporal modelling for forecasting and prediction of malaria infections using time-series and ARIMAX analyses: a case study in endemic districts of Bhutan
    Kinley Wangdi
    Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 9:251. 2010
  7. pmc Application of mobile-technology for disease and treatment monitoring of malaria in the "Better Border Healthcare Programme"
    Pongthep Meankaew
    Center of Excellence for Biomedical and Public Health Informatics BIOPHICS, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 9:237. 2010
  8. pmc Directly-observed therapy (DOT) for the radical 14-day primaquine treatment of Plasmodium vivax malaria on the Thai-Myanmar border
    Rie Takeuchi
    Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 9:308. 2010
  9. pmc The impact of human reservoir of malaria at a community-level on individual malaria occurrence in a low malaria transmission setting along the Thai-Myanmar border
    Saranath Lawpoolsri
    Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 9:143. 2010
  10. pmc Auditory assessment of patients with acute uncomplicated Plasmodium falciparum malaria treated with three-day mefloquine-artesunate on the north-western border of Thailand
    Verena I Carrara
    Shoklo Malaria Research Unit, Mae Sot, Thailand
    Malar J 7:233. 2008

Detail Information

Publications90

  1. pmc Artemisinin resistance containment project in Thailand. (I): Implementation of electronic-based malaria information system for early case detection and individual case management in provinces along the Thai-Cambodian border
    Amnat Khamsiriwatchara
    Center of Excellence for Biomedical and Public Health Informatics BIOPHICS, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 11:247. 2012
    ..The main objective of this study was to demonstrate the eMIS' functionality and outputs after implementation for use in the Thailand artemisinin-resistance containment project...
  2. pmc Artemisinin resistance containment project in Thailand. II: Responses to mefloquine-artesunate combination therapy among falciparum malaria patients in provinces bordering Cambodia
    Wichai Satimai
    Center of Excellence for Biomedical and Public Health Informatics BIOPHICS, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 11:300. 2012
    ..This study describes the response to artemisinin-based therapy among falciparum malaria patients in the area, using data from the malaria surveillance programmed under the containment project...
  3. pmc An analysis of health system resources in relation to pandemic response capacity in the Greater Mekong Subregion
    Piya Hanvoravongchai
    Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    Int J Health Geogr 11:53. 2012
    ..Investigation of healthcare resource distribution and inequalities can help determine the need for, and inform decisions regarding, resource sharing and mobilisation...
  4. pmc Chloroquine resistant vivax malaria in a pregnant woman on the western border of Thailand
    Marcus J Rijken
    Shoklo Malaria Research Unit, PO Box 46 Mae Sot, Tak 63110, Thailand
    Malar J 10:113. 2011
    ..vivax. This is the first clinically and laboratory confirmed case of two high-grade CQ resistant vivax parasite strains from Thailand...
  5. pmc Spatio-temporal patterns of malaria infection in Bhutan: a country embarking on malaria elimination
    Kinley Wangdi
    Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 10:89. 2011
    ..Poisson regression was performed to study the trend of malaria incidences at district level from 1994 to 2008. Spatial Empirical Bayesian smoothing was deployed to identify clusters of malaria at the sub-district level from 2004 to 2008...
  6. pmc Development of temporal modelling for forecasting and prediction of malaria infections using time-series and ARIMAX analyses: a case study in endemic districts of Bhutan
    Kinley Wangdi
    Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 9:251. 2010
    ..To strengthen the country's prevention and control measures, this study was carried out to develop forecasting and prediction models of malaria incidence in the endemic districts of Bhutan using time series and ARIMAX...
  7. pmc Application of mobile-technology for disease and treatment monitoring of malaria in the "Better Border Healthcare Programme"
    Pongthep Meankaew
    Center of Excellence for Biomedical and Public Health Informatics BIOPHICS, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 9:237. 2010
    ..The module for disease and treatment monitoring of malaria (DTMM) consisted of case investigation and case follow-up for treatment compliance and patients' symptoms...
  8. pmc Directly-observed therapy (DOT) for the radical 14-day primaquine treatment of Plasmodium vivax malaria on the Thai-Myanmar border
    Rie Takeuchi
    Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 9:308. 2010
    ..vivax malaria infection, to prevent reappearance of the parasite within the 90-day follow-up period. Other potential risk factors for the reappearance of P. vivax were also explored...
  9. pmc The impact of human reservoir of malaria at a community-level on individual malaria occurrence in a low malaria transmission setting along the Thai-Myanmar border
    Saranath Lawpoolsri
    Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 9:143. 2010
    ..This is essential for planning effective intervention strategies specifically for each location...
  10. pmc Auditory assessment of patients with acute uncomplicated Plasmodium falciparum malaria treated with three-day mefloquine-artesunate on the north-western border of Thailand
    Verena I Carrara
    Shoklo Malaria Research Unit, Mae Sot, Thailand
    Malar J 7:233. 2008
    ..The debate remains as to whether artemisinin derivatives induce similar toxicity in humans...
  11. pmc Optimally timing primaquine treatment to reduce Plasmodium falciparum transmission in low endemicity Thai-Myanmar border populations
    Saranath Lawpoolsri
    Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Malar J 8:159. 2009
    ....
  12. pmc Spatio-temporal effects of estimated pollutants released from an industrial estate on the occurrence of respiratory disease in Maptaphut Municipality, Thailand
    Somchai Jadsri
    Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Rajvithi Road, Bangkok, Thailand
    Int J Health Geogr 5:48. 2006
    ....
  13. pmc Application of smart phone in "Better Border Healthcare Program": a module for mother and child care
    Jaranit Kaewkungwal
    Center of Excellence for Biomedical and Public Health Informatics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    BMC Med Inform Decis Mak 10:69. 2010
    ..To assess the application of cell phone integrating into the healthcare system to improve antenatal care (ANC) and expanded programme on immunization (EPI) services for the under-served population in border area...
  14. ncbi request reprint Malaria in tree crop plantations in south-eastern and western provinces of Thailand
    P Singhasivanon
    Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Southeast Asian J Trop Med Public Health 30:399-404. 1999
    ..dirus and An. minimus are prevalent and have adapted to such changed ecosystems...
  15. pmc Longitudinal study of Plasmodium falciparum and Plasmodium vivax in a Karen population in Thailand
    Waraphon Phimpraphi
    Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 7:99. 2008
    ..falciparum prevalence and incidence rates, but has been less successful for P. vivax. The high transmissibility of P. vivax and its capacity to relapse have been suggested to make it a harder parasite species to control...
  16. ncbi request reprint Mekong malaria. Malaria, multi-drug resistance and economic development in the greater Mekong subregion of Southeast Asia
    P Singhasivanon
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Southeast Asian J Trop Med Public Health 30:i-iv, 1-101. 1999
    ..This beginning can form a basis for the development of an effective regional malaria surveillance system in the context of rapidly evolving social and infrastructural change, leading eventually to a multi-disease surveillance network...
  17. pmc Can treatment of P. vivax lead to a unexpected appearance of falciparum malaria?
    D P Mason
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Southeast Asian J Trop Med Public Health 32:57-63. 2001
    ..Both clinical results and features of the model suggest that such "hidden infections" may be quite common, and that the appearance of P. falciparum may be stimulated by treatment of P. vivax...
  18. ncbi request reprint Chloroquine sensitivity of Plasmodium vivax in Thailand
    S Looareesuwan
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Ann Trop Med Parasitol 93:225-30. 1999
    ..These data indicate that virtually all acute (i.e. blood-stage) P. vivax infections acquired in Thailand can still be successfully treated with chloroquine...
  19. ncbi request reprint The Asian center of international parasite control (ACIPAC): five years of achievement. I. Introduction
    Somei Kojima
    Asian Center of International Parasite Control, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    Southeast Asian J Trop Med Public Health 36:1-12. 2005
    ..As described in the Joint Evaluation Report, ACIPAC is expected to further contribute to human resource development and to strengthening human resource and information networking at regional and global levels...
  20. doi request reprint Development and validation of a high-throughput zwitterionic hydrophilic interaction liquid chromatography solid-phase extraction-liquid chromatography-tandem mass spectrometry method for determination of the anti-influenza drug peramivir in plasma
    N Lindegardh
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    J Chromatogr A 1215:145-51. 2008
    ..Validation of over-curve samples ensured that it would be possible with dilution if samples went outside the calibration range...
  21. doi request reprint A liquid chromatographic-tandem mass spectrometric method for determination of artesunate and its metabolite dihydroartemisinin in human plasma
    W Hanpithakpong
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    J Chromatogr B Analyt Technol Biomed Life Sci 876:61-8. 2008
    ..The method was free from matrix effects as demonstrated both graphically and quantitatively...
  22. ncbi request reprint Clinical trial of halofantrine with modified doses for treatment of malaria in the hospital for tropical diseases
    S Krudsood
    Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Southeast Asian J Trop Med Public Health 32:255-61. 2001
    ..Thus, halofantrine has high efficacy in the recommended treatment dose of 500 mg three times after meals on the first day followed by 500 mg once a day after a meal for 7 days (total dose: 4,500 mg)...
  23. doi request reprint Major pitfalls in the measurement of artemisinin derivatives in plasma in clinical studies
    N Lindegardh
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    J Chromatogr B Analyt Technol Biomed Life Sci 876:54-60. 2008
    ..These various pitfalls have undoubtedly contributed to the large inter-subject variation in plasma concentration profiles and derived pharmacokinetic parameters for these important antimalarial drugs...
  24. pmc Quantification of artemisinin in human plasma using liquid chromatography coupled to tandem mass spectrometry
    N Lindegardh
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    J Pharm Biomed Anal 49:768-73. 2009
    ..The limit of detection was 0.257 ng/mL for artemisinin and the calibration range was 1.03-762 ng/mL using 50 microL plasma. The method was free from matrix effects as demonstrated both graphically and quantitatively...
  25. ncbi request reprint The Asian Center of International Parasite Control (ACIPAC): five years of achievement. II. ACIPAC human resources development
    Jitra Waikagul
    Asian Center of International Parasite Control, Department of Helminthology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Southeast Asian J Trop Med Public Health 36:13-6. 2005
  26. ncbi request reprint Directly observed therapy with primaquine to reduce the recurrence rate of plasmodium vivax infection along the Thai-Myanmar border
    Wanchai Maneeboonyang
    Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Southeast Asian J Trop Med Public Health 42:9-18. 2011
    ..Survival analysis also showed significant differences between the SAT and DOT groups (p <0.05). The study suggests patient compliance with the 14-day primaquine treatment with DOT improve the outcome of .vivax malaria treatment...
  27. ncbi request reprint Causal relationship between health promoting behavior and quality of life in cervical cancer patients undergoing radiotherapy
    Pimsurang Taechaboonsermsak
    Department of Social and Environmental Medicine, Faculty of Tropical Medicine, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    Southeast Asian J Trop Med Public Health 36:1568-75. 2005
    ..A longitudinal study and experimental study are recommended for further study...
  28. doi request reprint Dengue is a major global health problem. Foreword
    Pratap Singhasivanon
    Regional Centre for Tropical Medicine, Mahidol University, Thailand
    J Clin Virol 46:S1-2. 2009
    ..Accurate disease surveillance and carefully monitored clinical trials will provide essential evidence concerning the efficacy of candidate dengue vaccines, which will hopefully herald a new era in dengue disease prevention...
  29. ncbi request reprint A human volunteer challenge model using frozen bacteria of the new epidemic serotype, V. cholerae O139 in Thai volunteers
    P Pitisuttithum
    Vaccine Trial Centre VTC, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Vaccine 20:920-5. 2001
    ..Cholera O139 in a human experimental challenge model to assess cholera vaccine efficacy (VE) in a cholera endemic area but with 4 days observation period before initiation of tetracycline to allow assessment of severity...
  30. pmc A comparison of two short-course primaquine regimens for the treatment and radical cure of Plasmodium vivax malaria in Thailand
    Sasithon Pukrittayakamee
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 82:542-7. 2010
    ..A 1 week course of primaquine 60 mg daily is an effective treatment of vivax malaria in this region...
  31. doi request reprint Chloroquine pharmacokinetics in pregnant and nonpregnant women with vivax malaria
    Sue Jean Lee
    Mahidol Oxford Tropical Medicine Research Unit, MORU, Mahidol University, Bangkok, Thailand
    Eur J Clin Pharmacol 64:987-92. 2008
    ..We compared the pharmacokinetics of chloroquine in pregnant and nonpregnant women treated for Plasmodium vivax malaria...
  32. ncbi request reprint Temporal patterns and forecast of dengue infection in Northeastern Thailand
    Tassanee Silawan
    Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok
    Southeast Asian J Trop Med Public Health 39:90-8. 2008
    ..27 to 17.89 per 100,000 population. The peak for 2006 should be much higher than the peak for 2005. The highest peaks in 2006 should be in Loei, Buri Ram, Surin, Nakhon Phanom, and Ubon Ratchathani Provinces...
  33. ncbi request reprint Risk factors for Plasmodium vivax gametocyte carriage in Thailand
    Mathieu Nacher
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 71:693-5. 2004
    ..97-0.99, P = 0.006), albumin (AOR = 0.67 per 10 g/mL increase, 95% CI = 0.5-0.9, P = 0.007), and anion gap (AOR = 1.1 per unit increase, 95% CI = 1.02-1.14, P = 0.009). The possible significance of these observations is discussed...
  34. ncbi request reprint Use of GIS-based spatial modeling approach to characterize the spatial patterns of malaria mosquito vector breeding habitats in northwestern Thailand
    Ratana Sithiprasasna
    Department of Entomology, US Army Medical Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
    Southeast Asian J Trop Med Public Health 34:517-28. 2003
    ..These associations permit real-time monitoring and possibly forecasting of the distributions of these four species, enabling public health agencies to institute control measures before the mosquitos emerge as adults and transmit disease...
  35. ncbi request reprint Association of intestinal helminths with decreased liver size and sCD23 concentration during falciparum malaria
    Mathieu Nacher
    Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Southeast Asian J Trop Med Public Health 35:31-4. 2004
    ..40, p < 0.0001). All the above results remained significant after controlling for potential confounders. These results are compatible with a CD23/NO-mediated decrease in liver size in helminth-infected patients...
  36. pmc Spatio-temporal patterns of leptospirosis in Thailand: is flooding a risk factor?
    S Suwanpakdee
    Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Thailand
    Epidemiol Infect 143:2106-15. 2015
    ..We conclude that leptospirosis remains an occupational disease in Thailand. ..
  37. ncbi request reprint Risk factors of multidrug resistant tuberculosis in central Nepal: a pilot study
    S B Marahatta
    Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Thailand
    Kathmandu Univ Med J (KUMJ) 8:392-7. 2010
    ..Incidences of drug resistant tuberculosis in Nepal are increasing and this tuberculosis a major threat to successfully controlling tuberculosis...
  38. ncbi request reprint Effect of primaquine standard dose (15 mg/day for 14 days) in the treatment of vivax malaria patients in Thailand
    K Buchachart
    Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Southeast Asian J Trop Med Public Health 32:720-6. 2001
    ..Daily doses of 15 mg of primaquine for 14 days following a full course of chloroquine when prescribed to Thai G6PD deficient patients where Mahidol variant is predominant, are relatively safe...
  39. ncbi request reprint Hepatitis B among pregnant women attending health care facilities in rural Bangladesh
    Md Shamsuzzaman
    Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Southeast Asian J Trop Med Public Health 42:1410-3. 2011
    ..Hepatitis B has a low prevalence among pregnant women in rural Bangladesh. Existing hepatitis B vaccination schedule in the Expanded Program on Immunization (EPI) to vaccinate the children in rural Bangladesh is appropriate...
  40. doi request reprint Adherence and efficacy of supervised versus non-supervised treatment with artemether/lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Bangladesh: a randomised controlled trial
    Md Mushfiqur Rahman
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    Trans R Soc Trop Med Hyg 102:861-7. 2008
    ..62; P=0.027). The efficacy of artemether/lumefantrine for the treatment of uncomplicated falciparum malaria in Bangladesh is high and is similar for DOT and NDOT. Adherence to therapy is high...
  41. ncbi request reprint A survey of the Th2R and Th3R allelic variants in the circumsporozoite protein gene of P. falciparum parasites from western Thailand
    Chutima Kumkhaek
    Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Southeast Asian J Trop Med Public Health 35:281-7. 2004
    ..However, the Th2R*05 and the Th3R*01 allelic variants predominated, as they were found in more than 70% of the 101 sequences obtained...
  42. pmc Dihydroartemisinin-piperaquine versus chloroquine to treat vivax malaria in Afghanistan: an open randomized, non-inferiority, trial
    Ghulam Rahim Awab
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 9:105. 2010
    ..Chloroquine resistance in P. vivax is emerging in Asia. Therapeutic responses across Afghanistan have not been evaluated in detail...
  43. ncbi request reprint Effects of different antimalarial drugs on gametocyte carriage in P. vivax malaria
    Sasithon Pukrittayakamee
    Department of Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 79:378-84. 2008
    ..4% versus 14.1%, P = 0.002). Sexual stage activities corresponded with asexual stage activity for all tested regimens. Treatment with potent antimalarial drugs reduces the transmission potential of P. vivax...
  44. pmc Artemisinin resistance in Plasmodium falciparum malaria
    Arjen M Dondorp
    Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    N Engl J Med 361:455-67. 2009
    ..There are recent concerns that the efficacy of such therapies has declined on the Thai-Cambodian border, historically a site of emerging antimalarial-drug resistance...
  45. pmc Pharmacokinetics of high-dose oseltamivir in healthy volunteers
    Y Wattanagoon
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Antimicrob Agents Chemother 53:945-52. 2009
    ..Probenecid coadministration may allow considerable dose saving for oseltamivir, but more information on OC penetration into respiratory secretions is needed to devise appropriate dose regimens...
  46. pmc Population pharmacokinetics of lumefantrine in pregnant women treated with artemether-lumefantrine for uncomplicated Plasmodium falciparum malaria
    Joel Tarning
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Antimicrob Agents Chemother 53:3837-46. 2009
    ..In conclusion, altered pharmacokinetic properties of lumefantrine contribute to the high rates of failure of artemether-lumefantrine treatment in later pregnancy. Dose optimization is urgently needed...
  47. ncbi request reprint Sexual behaviors of alcohol drinkers and non-drinkers among adolescents and young adults in Nha Trang, Vietnam
    Le Huu Tho
    Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, 420 6 Ratchawithi Road, Bangkok 10400, Thailand
    Southeast Asian J Trop Med Public Health 38:152-60. 2007
    ..8% and 1.6% of non-drinkers, respectively. These significant findings will be baseline data for integrating and adapting into intervention programs for alcohol and HIV among Vietnamese youth...
  48. ncbi request reprint Gender differences in epidemiological factors associated with treatment completion status of leprosy patients in the most hyperendemic district of Nepal
    Rajendra B C Kumar
    Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Southeast Asian J Trop Med Public Health 35:334-9. 2004
    ..37, 95% CI: 1.12-4.99), disability grade I (adjusted OR 3.14, 95% CI: 1.23-8.04), and disability grade 0 (adjusted OR 2.92, 95% CI: 1.14-7.47) after adjustment for all other leprosy/demographic factors...
  49. ncbi request reprint A simple and rapid liquid chromatographic assay for evaluation of potentially counterfeit Tamiflu
    N Lindegardh
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    J Pharm Biomed Anal 42:430-3. 2006
    ..5; 0.1M) (50:50, v/v) at a flow rate of 1.0mL/min. The assay was implemented for the analysis of Tamiflu purchased over the Internet and at local pharmacies in Thailand and Vietnam...
  50. ncbi request reprint Validation and application of a liquid chromatographic-mass spectrometric method for determination of artesunate in pharmaceutical samples
    N Lindegardh
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    J Pharm Biomed Anal 45:149-53. 2007
    ..3 (70:30, v/v) at a flow rate of 1 mL/min. The assay was implemented for the analysis of artesunate for injection purchased from Guilin Pharmaceutical Company in China...
  51. ncbi request reprint Primary verification: is the TRISS appropriate for Thailand?
    J Podang
    Department of Epidemiology, Faculty of Public Health, Mahidol University, Bangkok
    Southeast Asian J Trop Med Public Health 35:188-94. 2004
    ..By applying TRISS, the survival prediction of Thai road traffic injuries resulted in a high number of false positives...
  52. ncbi request reprint Melioidosis in 6 tsunami survivors in southern Thailand
    Wirongrong Chierakul
    Department of Clinical Tropical Medicine, Wellcome TrustMahidol UniversityOxford Tropical Medicine Research Programme, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Clin Infect Dis 41:982-90. 2005
    ..All 6 cases were associated with aspiration, and 4 were also associated with laceration...
  53. ncbi request reprint Are extensive T cell epitope polymorphisms in the Plasmodium falciparum circumsporozoite antigen, a leading sporozoite vaccine candidate, selected by immune pressure?
    Chutima Kumkhaek
    Department of Microbiology and Immunology, Mahidol University, Bangkok, Thailand
    J Immunol 175:3935-9. 2005
    ..We provide evidence that polymorphisms in the T cell epitopes of a malaria vaccine candidate are unlikely to have been selected by immune pressure in the human host...
  54. ncbi request reprint Molecular characterization of hereditary persistence of fetal hemoglobin in the Karen people of Thailand
    Objoon Trachoo
    Department of Medicine, Division of Medical Genetics and Molecular Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    Hemoglobin 27:97-104. 2003
    ..Hence, genetic counseling for hereditary persistence of Hb F carriers is needed for family planning...
  55. ncbi request reprint Potential association of dengue hemorrhagic fever incidence and remote senses land surface temperature, Thailand, 1998
    Narong Nitatpattana
    Center for Vaccine Development, Research Center for Emerging Viral Disease, Institute of Science and Technology for Research and Development, Mahidol University, Nakhon Pathom, Thailand
    Southeast Asian J Trop Med Public Health 38:427-33. 2007
    ..Non-climatic factors are supposed to be at the origin of this discrepancy between seasonality in climate (LST) and DHF incidence during epidemics...
  56. ncbi request reprint Trend of malaria incidence in highly endemic provinces along the Thai borders, 1991-2001
    Supawadee Konchom
    Bureau of Vector Borne Disease, Ministry of Public Health, Nonthaburi, Thailand
    Southeast Asian J Trop Med Public Health 34:486-94. 2003
    ....
  57. ncbi request reprint Malaria education from school to community in Oudomxay province, Lao PDR
    Daisuke Nonaka
    Department of International Community Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Parasitol Int 57:76-82. 2008
    ..In conclusion, our results suggest that school children can act as health information messengers from schools to communities for malaria control in Lao PDR...
  58. ncbi request reprint Chronicle of malaria epidemics in Thailand, 1980-2000
    Supawadee Konchom
    Bureau of Vector Borne Disease, Department of Disease Control, Ministry of Public Health, Nonthaburi 11000, Thailand
    Southeast Asian J Trop Med Public Health 36:64-7. 2005
    ..Evidence related to the burden of malaria epidemics was also reviewed to identify causal factors that will be helpful in future research...
  59. ncbi request reprint Gender difference in socio-epidemiological factors for leprosy in the most hyper-endemic district of Nepal
    Rajendra Kumar
    Health Research Section, Nepal Health Research Council, Ramshah Path, Kathmandu, Nepal
    Nepal Med Coll J 6:98-105. 2004
    ....
  60. pmc Deployment of early diagnosis and mefloquine-artesunate treatment of falciparum malaria in Thailand: the Tak Malaria Initiative
    Verena Ilona Carrara
    Shoklo Malaria Research Unit, Tak, Thailand
    PLoS Med 3:e183. 2006
    ..We extended the same combination drug strategy to all other communities (estimated population 450,000) living in five border districts of Tak province in northwestern Thailand...
  61. ncbi request reprint Mekong malaria. II. Update of malaria, multi-drug resistance and economic development in the Mekong region of Southeast Asia
    Doung Socheat
    Center for National Malaria Control CNM, Phnom Penh, Cambodia
    Southeast Asian J Trop Med Public Health 34:1-102. 2003
    ....
  62. ncbi request reprint Ikonos-derived malaria transmission risk in northwestern Thailand
    Ratana Sithiprasasna
    Department of Entomology, US Army Medical Component, Armed Forces Research Institute of Medical Sciences, Bangkok
    Southeast Asian J Trop Med Public Health 36:14-22. 2005
    ..5 km. The An. minimus larval habitat deserves more detailed investigation. Further studies on human behavior contrary to that required for adequate malaria control among these three villages are also recommended...
  63. ncbi request reprint An open label randomized comparison of mefloquine-artesunate as separate tablets vs. a new co-formulated combination for the treatment of uncomplicated multidrug-resistant falciparum malaria in Thailand
    Elizabeth A Ashley
    Shoklo Malaria Research Unit, Tak, Thailand
    Trop Med Int Health 11:1653-60. 2006
    ..A new fixed combination of mefloquine plus artesunate has been developed. This was compared with the conventional regimen of separate tablets for the treatment of uncomplicated multidrug-resistant falciparum malaria...
  64. ncbi request reprint Beyond deworming: the promotion of school-health-based interventions by Japan
    Jun Kobayashi
    Bureau of International Cooperation, International Medical Centre of Japan IMCJ, Ministry of Health, Labor and Welfare, 1 21 1 Toyama, Shinjuku ku, Tokyo 162 8655, Japan
    Trends Parasitol 23:25-9. 2007
    ..Implementing "beyond-deworming" efforts is now a practical challenge in the subregion...
  65. ncbi request reprint Application of real-time polymerase chain reaction (PCR) analysis for detection and discrimination of malaria parasite species in Thai patients
    Yuko Katakai
    Department of Appropriate Technology Development and Transfer, Research Institute, International Medical Center of Japan, Tokyo, Japan
    Southeast Asian J Trop Med Public Health 35:10-4. 2004
    ..Real-time PCR analysis was shown to be more sensitive and accurate than routine diagnostic methods. Application and extension of the PCR method reported here will provide a powerful tool for further studies of malaria...
  66. ncbi request reprint Beyond deworming
    Masamine Jimba
    Lancet 365:751. 2005
  67. ncbi request reprint Gender difference in treatment seeking behaviors of tuberculosis cases in rural communities of Bangladesh
    Giasuddin Ahsan
    DGHS, Ministry of Health and FW, Dhaka, Bangladesh
    Southeast Asian J Trop Med Public Health 35:126-35. 2004
    ....
  68. ncbi request reprint Effects of mefloquine usage on genetic polymorphism of Plasmodium falciparum in Thai-Myanmarese border
    Toshiaki Matsuo
    International Center for Medical Research, Kobe University School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Kobe J Med Sci 49:143-51. 2003
    ..Our study strongly suggests that the antigenic diversity of Plasmodium falciparum is retained during mefloquine therapy in low-transmission areas...
  69. ncbi request reprint Helminth infections are associated with protection from cerebral malaria and increased nitrogen derivatives concentrations in Thailand
    Mathieu Nacher
    Unité INSERM 511 Immunobiologie Cellulaire et Moléculaire des Infections Parasitaires, Faculté de Médecine Pitié Salpêtrière, Paris, France
    Am J Trop Med Hyg 66:304-9. 2002
    ..Helminths increasing both the CD23 receptor and its ligand may have a role in the establishment of malaria tolerance through the CD23/NO pathway...
  70. pmc A randomized trial of artemether-lumefantrine versus mefloquine-artesunate for the treatment of uncomplicated multi-drug resistant Plasmodium falciparum on the western border of Thailand
    Robert Hutagalung
    Shoklo Malaria Research Unit, Mae Sod, Tak Province, Thailand
    Malar J 4:46. 2005
    ..The trial presented here was conducted to monitor the efficacy of the six-dose regimen of artemether-lumefantrine (ALN) in an area of multi-drug resistance, along the Thai-Myanmar border...
  71. ncbi request reprint Relationship between reactive nitrogen intermediates and total immunoglobulin E, soluble CD21 and soluble CD23: comparison between cerebral malaria and nonsevere malaria
    Mathieu Nacher
    Unité INSERM 511, Immunobiologie Cellulaire et Moleculaire des Infections Parasitaires, Faculté de Médecine Pitié Salpêtrière, Paris, France
    Parasite Immunol 24:395-9. 2002
    ....
  72. ncbi request reprint Some entomological observations on temporal and spatial distribution of malaria vectors in three villages in northwestern Thailand using a geographic information system
    Ratana Sithiprasasna
    Department of Entomology, US Army Medical Component, Armed Forces Research Institute of Medical Sciences, Thailand
    Southeast Asian J Trop Med Public Health 34:505-16. 2003
    ....
  73. ncbi request reprint Water quality and breeding habitats of anopheline mosquito in northwestern Thailand
    Ampornpan Kengluecha
    Department of Entomology, US Army Medical Component, Armed Forces Research Institute of Medical Sciences, Bangkok
    Southeast Asian J Trop Med Public Health 36:46-53. 2005
    ..campestris larvae (p < 0.001); and pH and silica concentration for An. vagus larvae (p < 0.001). We could not identify key environmental variables for An. maculatus, An. sawadwongporni, An. peditaeniatus, and An. barbirostris...
  74. pmc Comparison of artesunate and chloroquine activities against Plasmodium vivax gametocytes
    Mathieu Nacher
    Centre Hospitalier de Cayenne, Avenue des Flamboyants, 97300 Cayenne, French Guiana
    Antimicrob Agents Chemother 48:2751-2. 2004
    ..0001). The duration and magnitude of gametocyte carriage were also lower for artesunate than chloroquine. By reducing the transmission of Plasmodium vivax to the vector, artesunate could therefore reduce the incidence of P. vivax malaria...
  75. ncbi request reprint Dihydroartemisinin-piperaquine rescue treatment of multidrug-resistant Plasmodium falciparum malaria in pregnancy: a preliminary report
    Marcus J Rijken
    Shoklo Malaria Research Unit, Mae Sot, Tak, Thailand
    Am J Trop Med Hyg 78:543-5. 2008
    ..This rescue treatment was effective and well tolerated and there was no evidence of toxicity for the mothers or the fetus. The PCR adjusted cure rate by Kaplan Meier analysis at day 63 was 92.2% (95% CI: 76.9-97.4)...
  76. ncbi request reprint In vitro susceptibility and genetic variations for chloroquine and mefloquine in Plasmodium falciparum isolates from Thai-Myanmar border
    Toshimitsu Hatabu
    Research Institute, International Medical Center of Japan, Tokyo, Japan
    Southeast Asian J Trop Med Public Health 36:73-9. 2005
    ..A pfmdr1 D1042 mutation was also present in 7 isolates, while no pfmdr1 Y1246 mutation was observed. These results indicated a correlation between CQ resistance and the pfcrt T76 and pfmdr1 Y86 mutations...
  77. ncbi request reprint Electrocardiographic safety evaluation of dihydroartemisinin piperaquine in the treatment of uncomplicated falciparum malaria
    Oliver T Mytton
    Shoklo Malaria Research Unit, Mae Sot, Thailand
    Am J Trop Med Hyg 77:447-50. 2007
    ..At therapeutic doses, DP does not have clinically significant effects on the electrocardiogram...
  78. pmc In vitro activity of ferroquine (SSR 97193) against Plasmodium falciparum isolates from the Thai-Burmese border
    Marion Barends
    Shoklo Malaria Research Unit, Mae Sot, Tak, Thailand
    Malar J 6:81. 2007
    ..The aim of the present study was to investigate the activity of ferroquine against P. falciparum isolates from an area with a known high multi-drug resistance rate...
  79. ncbi request reprint Early detection of malaria in an endemic area: model development
    Supawadee Konchom
    Bureau of Vector Borne Disease, Ministry of Public Health, Nonthaburi 11000, Thailand
    Southeast Asian J Trop Med Public Health 37:1067-71. 2006
    ..The model may be helpful in the decision making process, planning and budget allocation for the Malaria Control Program. The software for early malaria detection is currently implemented in several endemic areas throughout Thailand...
  80. ncbi request reprint Pharmacokinetic study of artemether-lumefantrine given once daily for the treatment of uncomplicated multidrug-resistant falciparum malaria
    Elizabeth A Ashley
    Shoklo Malaria Research Unit, Mae Sot, Thailand
    Trop Med Int Health 12:201-8. 2007
    ..If the fixed antimalarial drug combination artemether-lumefantrine (AL) could be given once daily, this should improve adherence and thus effectiveness and lower the risk of selecting for resistance...
  81. ncbi request reprint Meteorological, environmental remote sensing and neural network analysis of the epidemiology of malaria transmission in Thailand
    Richard Kiang
    NASA Goddard Space Flight Center, Greenbelt, Maryland 20771, USA
    Geospat Health 1:71-84. 2006
    ..When other contextual determinants do not vary significantly, using neural network analysis along with remote sensing variables to predict malaria endemicity should be feasible...
  82. ncbi request reprint How much fat is necessary to optimize lumefantrine oral bioavailability?
    Elizabeth A Ashley
    Shoklo Malaria Research Unit, Mae Sot, Thailand
    Trop Med Int Health 12:195-200. 2007
    ..The aim of this study was to describe the dose-response relationship between coadministration of fat and relative lumefantrine bioavailability, in order to determine the minimum amount of fat necessary to optimize absorption...
  83. ncbi request reprint In vivo sensitivity monitoring of mefloquine monotherapy and artesunate-mefloquine combinations for the treatment of uncomplicated falciparum malaria in Thailand in 2003
    Elizabeth Ashley
    Trop Med Int Health 11:1898-9; author reply 1899. 2006
  84. pmc Intrahost selection of Plasmodium falciparum pfmdr1 alleles after antimalarial treatment on the northwestern border of Thailand
    Anne Catrin Uhlemann
    Centre for Infection, Division of Cellular and Molecular Medicine, St George s, University of London, London, United Kingdom
    J Infect Dis 195:134-41. 2007
    ..We assessed how administration of different antimalarial drugs altered pfmdr1 polymorphism in parasites from patients who experienced treatment failure...
  85. ncbi request reprint The pharmacokinetics of artemether and lumefantrine in pregnant women with uncomplicated falciparum malaria
    Rose McGready
    Shoklo Malaria Research Unit, P O Box 46, Mae Sot, Tak, Thailand
    Eur J Clin Pharmacol 62:1021-31. 2006
    ..To determine the pharmacokinetic properties of artemether and lumefantrine (AL) in pregnant women with recrudescent uncomplicated multi-drug resistant falciparum malaria...
  86. pmc Population pharmacokinetic assessment of a new regimen of mefloquine used in combination treatment of uncomplicated falciparum malaria
    Elizabeth A Ashley
    Shoklo Malaria Research Unit, P O Box 46, Mae Sot, Tak 63110, Thailand
    Antimicrob Agents Chemother 50:2281-5. 2006
    ..This new regimen is well tolerated and results in an equivalent therapeutic response...
  87. pmc Manslaughter by fake artesunate in Asia--will Africa be next?
    Paul N Newton
    Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Churchill Hospital, Oxford, United Kingdom
    PLoS Med 3:e197. 2006
  88. pmc Molecular and pharmacological determinants of the therapeutic response to artemether-lumefantrine in multidrug-resistant Plasmodium falciparum malaria
    Ric N Price
    Centre for Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom
    Clin Infect Dis 42:1570-7. 2006
    ..Our study examined the relative contributions of host, pharmacokinetic, and parasitological factors in determining the therapeutic response to artemether-lumefantrine (AL)...
  89. ncbi request reprint A case-control auditory evaluation of patients treated with artemether-lumefantrine
    Robert Hutagalung
    Shoklo Malaria Research Unit, Mae Sot, Tak Province, Thailand
    Am J Trop Med Hyg 74:211-4. 2006
    ..There were no differences in the test results between cases and controls. There was no neurophysiologic evidence of auditory brainstem toxicity that could be attributed to artemether-lumefantrine in this study population...
  90. ncbi request reprint Decreased hemoglobin concentrations, hyperparasitemia, and severe malaria are associated with increased Plasmodium falciparum gametocyte carriage
    Mathieu Nacher
    Unité INSERM 511, Immunobiologie Cellulaire et Moleculaire des Infections Parasitaires, Faculté de Médecine Pitié Salpêtrière, Paris, France
    J Parasitol 88:97-101. 2002
    ..0001). These findings suggest that events surrounding anemia and tissue hypoxia stimulate Plasmodium falciparum gametocytogenesis...