Toshiaki Tanaka

Summary

Publications

  1. ncbi Growth hormone treatment in Japan: past, present, and future
    Toshiaki Tanaka
    Tanaka Grdwth Clinic, Famille Yoga 1F, 2 36 7 Yoga, Setagaya Ku, Tokyo 158 0097, Japan
    Pediatr Endocrinol Rev 10:89-97. 2012
  2. ncbi XI International Congress of AUXOLOGY, September 9-12, 2007, Tokyo, Japan
    Toshiaki Tanaka
    Tanaka Growth Clinic, Tokyo, Japan
    Pediatr Endocrinol Rev 5:804-9. 2008
  3. ncbi The 41st Annual Meeting of the Japanese Society for Pediatric Endocrinology (JSPE), Yokohama, Japan, 7-9 November 2007
    Toshiaki Tanaka
    Tanaka Growth Clinic, National Center for Child Health and Development, Tokyo, Japan
    Pediatr Endocrinol Rev 5:912-4. 2008
  4. ncbi Gene expression of mesenchyme forkhead 1 (FOXC2) significantly correlates with the degree of lymph node metastasis in colorectal cancer
    Toshiaki Watanabe
    Department of Surgery, Teikyo University School of Medicine, Itabashi ku, Tokyo, Japan
    Int Surg 96:207-16. 2011
  5. doi Chromosome 18q deletion as a novel molecular predictor for colorectal cancer with simultaneous hepatic metastasis
    Toshiaki Tanaka
    Department of Surgical Oncology, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Diagn Mol Pathol 18:219-25. 2009
  6. ncbi Poorly differentiated colorectal adenocarcinomas show higher rates of microsatellite instability and promoter methylation of p16 and hMLH1: a study matched for T classification and tumor location
    Yoshihiro Kazama
    Department of Surgical Oncology, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    J Surg Oncol 97:278-83. 2008
  7. doi Paradoxical Reductions in Serum Anti-p53 Autoantibody Levels by Chemotherapy in Unresectable Colorectal Cancer: An Observational Study
    Hiroaki Nozawa
    Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan
    Oncology 91:127-34. 2016
  8. ncbi Anatomy of the middle rectal artery: a review of the historical literature
    Tomomichi Kiyomatsu
    Department of Surgical Oncology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Surg Today 47:14-19. 2017
  9. doi Clinicopathological Features of Colorectal Cancer Patients Under the Age of 50: Recent Experience and Case-Control Study of Prognosis in a Japanese Cohort
    Yuzo Nagai
    Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    Digestion 93:272-9. 2016
  10. doi Prognostic impact of lymph node dissection is different for male and female colon cancer patients: a propensity score analysis in a multicenter retrospective study
    Soichiro Ishihara
    Department of Surgical Oncology, The University of Tokyo Hospital, 7 3 1, Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Int J Colorectal Dis 31:1149-55. 2016

Detail Information

Publications90

  1. ncbi Growth hormone treatment in Japan: past, present, and future
    Toshiaki Tanaka
    Tanaka Grdwth Clinic, Famille Yoga 1F, 2 36 7 Yoga, Setagaya Ku, Tokyo 158 0097, Japan
    Pediatr Endocrinol Rev 10:89-97. 2012
    ..With early diagnosis, early high-dose treatment, and low-dose estrogen replacement therapy, both adult height and quality of life (QOL) of the patients with Turner syndrome have been improved...
  2. ncbi XI International Congress of AUXOLOGY, September 9-12, 2007, Tokyo, Japan
    Toshiaki Tanaka
    Tanaka Growth Clinic, Tokyo, Japan
    Pediatr Endocrinol Rev 5:804-9. 2008
  3. ncbi The 41st Annual Meeting of the Japanese Society for Pediatric Endocrinology (JSPE), Yokohama, Japan, 7-9 November 2007
    Toshiaki Tanaka
    Tanaka Growth Clinic, National Center for Child Health and Development, Tokyo, Japan
    Pediatr Endocrinol Rev 5:912-4. 2008
  4. ncbi Gene expression of mesenchyme forkhead 1 (FOXC2) significantly correlates with the degree of lymph node metastasis in colorectal cancer
    Toshiaki Watanabe
    Department of Surgery, Teikyo University School of Medicine, Itabashi ku, Tokyo, Japan
    Int Surg 96:207-16. 2011
    ..FOXC2 appears to be involved in determining the aggressiveness of lymph node metastasis in colorectal cancer...
  5. doi Chromosome 18q deletion as a novel molecular predictor for colorectal cancer with simultaneous hepatic metastasis
    Toshiaki Tanaka
    Department of Surgical Oncology, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Diagn Mol Pathol 18:219-25. 2009
    ..This novel molecular predictor is helpful in identifying patients who would benefit from surgical resection...
  6. ncbi Poorly differentiated colorectal adenocarcinomas show higher rates of microsatellite instability and promoter methylation of p16 and hMLH1: a study matched for T classification and tumor location
    Yoshihiro Kazama
    Department of Surgical Oncology, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    J Surg Oncol 97:278-83. 2008
    ..Extensive genetic and epigenetic analysis of poorly differentiated colorectal adenocarcinomas (Por) has been difficult, as the number of cases is too small...
  7. doi Paradoxical Reductions in Serum Anti-p53 Autoantibody Levels by Chemotherapy in Unresectable Colorectal Cancer: An Observational Study
    Hiroaki Nozawa
    Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan
    Oncology 91:127-34. 2016
    ..The usefulness of this antibody has been suggested in screening for and the monitoring of recurrence in colorectal cancer; however, its significance as a marker during chemotherapy remains largely unknown...
  8. ncbi Anatomy of the middle rectal artery: a review of the historical literature
    Tomomichi Kiyomatsu
    Department of Surgical Oncology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Surg Today 47:14-19. 2017
    ..With advancements in endoscopic surgery, the knowledge of the precise anatomy of this structure is becoming more crucial for optimal rectal cancer surgery...
  9. doi Clinicopathological Features of Colorectal Cancer Patients Under the Age of 50: Recent Experience and Case-Control Study of Prognosis in a Japanese Cohort
    Yuzo Nagai
    Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    Digestion 93:272-9. 2016
    ..The incidence of colorectal cancer (CRC) in young people is increasing, indicating an urgent need for understanding young-onset CRC. This study serves to clarify the characteristics and prognosis of young CRC patients...
  10. doi Prognostic impact of lymph node dissection is different for male and female colon cancer patients: a propensity score analysis in a multicenter retrospective study
    Soichiro Ishihara
    Department of Surgical Oncology, The University of Tokyo Hospital, 7 3 1, Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Int J Colorectal Dis 31:1149-55. 2016
    ..Colon cancers in male and female patients are suggested to be oncologically different. The aim of this study is to elucidate the prognostic impact of lymph node dissection (LND) in male and female colon cancer patients...
  11. ncbi A high preoperative carbohydrate antigen 19-9 level is a risk factor for recurrence in stage II colorectal cancer
    Hiroaki Nozawa
    a Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan
    Acta Oncol . 2016
    ..This study aimed to identify risk factors for tumor recurrence and assess whether they are related to the benefits of adjuvant chemotherapy in stage II CRC...
  12. ncbi Adiponectin and colorectal cancer
    Kensuke Otani
    Department of Surgical Oncology, The University of Tokyo, Hongo7 3 1, Bunkyo ku, Tokyo, 113 8655, Japan
    Surg Today . 2016
    ..In this report, we summarize recent findings of the correlation between adiponectin and colorectal cancer and investigate the effect of adiponectin on colorectal cancer...
  13. doi Evaluation of the vascular anatomy of the right-sided colon using three-dimensional computed tomography angiography: a single-center study of 536 patients and a review of the literature
    Koji Murono
    Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Int J Colorectal Dis 31:1633-8. 2016
    ..Three-dimensional (3D)-computed tomography (CT) angiography is a less-invasive modality than traditional angiographic examination. Therefore, we aimed to evaluate branching patterns of the superior mesenteric artery (SMA)...
  14. pmc Level of arterial ligation in sigmoid colon and rectal cancer surgery
    Koji Yasuda
    Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo Hospital, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    World J Surg Oncol 14:99. 2016
    ..The aim of this study was to assess the utility of "low tie with LND" on survival in patients with sigmoid colon or rectal cancer...
  15. ncbi Survival Impact of Extracolorectal Malignancies in Colorectal Cancer Patients
    Kazushige Kawai
    Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    Digestion 94:92-99. 2016
    ..Although development of a second primary cancer and deaths thereof are included as events of disease-free survival (DFS) and overall survival (OS), the role of EMs in these survival end points has not been fully investigated...
  16. ncbi Laparoscopic versus open surgery for obese patients with rectal cancer: a retrospective cohort study
    Hiroyuki Matsuzaki
    Department of Surgical Oncology, The University of Tokyo Hospital, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Surg Today . 2016
    ..To evaluate the advantages of laparoscopic surgery for rectal cancer in obese patients...
  17. doi Hereditary gastrointestinal cancer
    Keisuke Hata
    Department of Surgical Oncology, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    Surg Today 46:1115-22. 2016
    ....
  18. ncbi Short-term outcomes of open versus laparoscopic surgery in elderly patients with colorectal cancer
    Takeshi Nishikawa
    Department of Surgical Oncology, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Surg Endosc 30:5550-5557. 2016
    ..Our purpose is to verify the safety and effectiveness of laparoscopic surgery for the treatment of colorectal cancer in elderly patients...
  19. pmc Incidence of neoplasias and effectiveness of postoperative surveillance endoscopy for patients with ulcerative colitis: comparison of ileorectal anastomosis and ileal pouch-anal anastomosis
    Hiroaki Ishii
    Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, Tokyo, 113 0033, Japan
    World J Surg Oncol 14:75. 2016
    ....
  20. doi 'Deepness of Response' Is Associated with Overall Survival in Standard Systemic Chemotherapy for Metastatic Colorectal Cancer
    Hiroaki Nozawa
    Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan
    Chemotherapy 60:360-7. 2014
    ..We determined whether this concept was universally applicable to diverse standard chemotherapeutic regimens for mCRC...
  21. ncbi Large Colorectal Carcinoma Is Predictive of Recurrence After Adjuvant Chemotherapy Using Oxaliplatin
    Hiroaki Nozawa
    Department of Surgical Oncology, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Anticancer Res 35:5073-8. 2015
    ..However, factors associated with recurrence despite adjuvant therapy are largely unknown...
  22. doi Laparoscopic surgery for ulcerative colitis: a review of the literature
    Keisuke Hata
    Department of Surgical Oncology, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Surg Today 45:933-8. 2015
    ..Some surgeons favor laparoscopic surgery even for severe acute colitis. More efforts are being made to develop newer laparoscopic methods, such as reduced port surgery, including single incision laparoscopic surgery and robotic surgery. ..
  23. doi The preoperative platelet to lymphocyte ratio is a prognostic marker in patients with stage II colorectal cancer
    Tsuyoshi Ozawa
    Department of Surgical Oncology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo Bunkyo ku, Tokyo, 113 8655, Japan
    Int J Colorectal Dis 30:1165-71. 2015
    ..The aim of this study was to evaluate the prognostic impact of the PLR in patients with stage II colorectal cancer (CRC) who have undergone curative resection but not adjuvant chemotherapy...
  24. doi New reference growth charts for Japanese girls with Turner syndrome
    Tsuyoshi Isojima
    Clinical Research Center, National Center for Child Health and Development, Ohkura, Setagaya Ku, Tokyo, 157 8535, Japan
    Pediatr Int 51:709-14. 2009
    ..These charts were published in 1992 and may no longer be valid for the evaluation of stature and growth in girls with TS in clinical settings. Thus, we need to establish new clinical growth charts...
  25. doi Predicting ulcerative colitis-associated colorectal cancer using reverse-transcription polymerase chain reaction analysis
    Toshiaki Watanabe
    Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan
    Clin Colorectal Cancer 10:134-41. 2011
    ..This study aimed to build a predictive model for the development of UC-Ca based on gene expression levels measured by reverse-transcription polymerase chain reaction (RT-PCR) analysis in nonneoplastic rectal mucosa...
  26. doi Intraoperative colonoscopy in patients with colorectal cancer: Review of recent developments
    Kazushige Kawai
    Department of Surgical Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Dig Endosc 28:633-40. 2016
    ....
  27. doi Surveillance colonoscopy for colitis-associated dysplasia and cancer in ulcerative colitis patients
    Keisuke Hata
    Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan
    Dig Endosc 28:260-5. 2016
    ..In the present review, we focus on the current detection methods and characterization of dysplasia/cancer and discuss the appropriate intervals of colonoscopy according to the stratified risks. ..
  28. pmc Giant mucocele of the colon at the distal stump due to low-grade mucinous neoplasia
    Toshiaki Tanaka
    Department of Surgical Oncology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Surg Case Rep 2:117. 2016
    ..With reference to low-grade mucinous neoplasia, we propose that complete surgical resection be performed for diagnosis and a favorable outcome...
  29. doi Pouchitis after ileal pouch-anal anastomosis in ulcerative colitis: diagnosis, management, risk factors, and incidence
    Keisuke Hata
    Department of Surgical Oncology, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Dig Endosc . 2016
    ..This article is protected by copyright. All rights reserved...
  30. pmc Successful endoscopic treatment of stapled J-pouch ileoanal canal anastomotic hemorrhage by argon plasma coagulation: a case report
    Takeshi Nishikawa
    Department of Surgical Oncology, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    J Med Case Rep 10:309. 2016
    ..We report a case of a patient with gastrointestinal hemorrhage 18 years after stapled J-pouch ileoanal canal anastomosis who was successfully treated with argon plasma coagulation...
  31. ncbi Clinical significance of mucinous components in rectal cancer after preoperative chemoradiotherapy
    Kensuke Kaneko
    Department of Surgical Oncology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Surg Today . 2016
    ..The clinical implications of mucinous components in rectal tumors, especially with regard to the efficacy of neoadjuvant chemoradiotherapy, remain unclear...
  32. pmc Asynchronous bilateral anastomosis site sigmoid colon cancer after ureterosigmoidostomy: a case report
    Keiichi Arakawa
    Department of Surgical Oncology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    World J Surg Oncol 14:180. 2016
    ..We present a case of asynchronously occurring adenocarcinomas 29 and 36 years after ureterosigmoidostomy for bladder cancer, respectively, at both anastomosis sites...
  33. doi LINE-1 hypomethylation status of circulating cell-free DNA in plasma as a biomarker for colorectal cancer
    Yuzo Nagai
    Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Oncotarget . 2017
    ..79 and 0.83 in stage I/II and stage III/IV CRC patients, respectively. The present study demonstrated for the first time the potential of plasma cfDNA LHI as a novel biomarker for CRC, particularly for early stage detection...
  34. doi Oncological benefit of lateral pelvic lymph node dissection for rectal cancer treated without preoperative chemoradiotherapy: a multicenter retrospective study using propensity score analysis
    Soichiro Ishihara
    Department of Surgical Oncology, The University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Int J Colorectal Dis 31:1315-21. 2016
    ..We aimed to clarify the prognostic impact of lateral pelvic lymph node (LPN) dissection (LPND) for rectal cancer through a multicenter retrospective study using propensity score analysis...
  35. pmc A case of disseminated carcinomatosis of the bone marrow originating from gastric cancer 3 years after intraperitoneal chemotherapy against peritoneal carcinomatosis
    Takayuki Okuno
    Department of Surgical Oncology, The University of Tokyo, 7 3 1 Bunkyo ku, Tokyo, 113 8655, Japan
    World J Surg Oncol 14:107. 2016
    ..Disseminated carcinomatosis of the bone marrow is highly rare in gastric cancer and associated with a poor prognosis...
  36. doi Prognostic Impact of Histologic Type in Curatively Resected Stage IV Colorectal Cancer: A Japanese Multicenter Retrospective Study
    Junichi Shibata
    Department of Surgical Oncology, University of Tokyo Hospital, The University of Tokyo, Tokyo, Japan
    Ann Surg Oncol 22:S621-9. 2015
    ..This study aimed to clarify differences in prognostic factors, metastatic features, and recurrence rates between histologic types in patients with stage 4 colorectal cancer (CRC) who had undergone curative resection...
  37. pmc Alpha-fetoprotein-producing early rectal carcinoma: a rare case report and review
    Hiroyuki Anzai
    Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    World J Surg Oncol 13:180. 2015
    ..Alpha-fetoprotein (AFP)-producing rectal cancer is very rare, and this type of cancer frequently metastasizes to the liver with a poor prognosis. To date, only 11 cases of AFP-producing colorectal cancer have been reported...
  38. doi Benefit of primary tumor resection in stage IV colorectal cancer with unresectable metastasis: a multicenter retrospective study using a propensity score analysis
    Soichiro Ishihara
    Department of Surgical Oncology, The University of Tokyo Hospital, 7 3 1, Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Int J Colorectal Dis 30:807-12. 2015
    ..The aim of this study was to investigate the prognostic impact of primary tumor resection in various subgroups of mCRC patients...
  39. doi Recent advances in robotic surgery for rectal cancer
    Soichiro Ishihara
    Department of Surgical Oncology, The University of Tokyo Hospital, 7 3 1, Bunkyo ku, Hongo, Tokyo, 113 8655, Japan
    Int J Clin Oncol 20:633-40. 2015
    ..However, long-term outcomes and the cost-effectiveness of robotic surgery for rectal cancer have not been fully evaluated yet; therefore, large-scale clinical studies are required to evaluate the efficacy of this new technology. ..
  40. ncbi CD133 Expression in Lymph Node Metastases Is Associated with Tumor Aggressiveness During Lymph Node Metastasis in Colorectal Cancer
    Shinsuke Kazama
    Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Anticancer Res 35:6599-605. 2015
    ..However, the expression of CD133 in lymph node metastases as well as in primary tumors in CRC remains to be elucidated...
  41. doi Patient factors predisposing to complications following laparoscopic surgery for colorectal cancers
    Soichiro Ishihara
    Department of Surgical Oncology, The University of Tokyo Hospital, Hongo, Bunkyo ku Department of Surgery, Teikyo University, Kaga, Itabashi ku, Tokyo, Japan
    Surg Laparosc Endosc Percutan Tech 25:168-72. 2015
    ..91, P=0.0102) and cancer stage (stage 2/stage 4: OR=0.17, P=0.0247) were risk factors for noninfectious complications. This study shows that different patient factors are associated with the risk of different types of complications. ..
  42. doi Long-term efficacy and safety of two doses of growth hormone in short Japanese children born small for gestational age
    Toshiaki Tanaka
    Tanaka Growth Clinic, Tokyo, Japan
    Horm Res Paediatr 76:411-8. 2011
    ..To investigate the long-term efficacy and safety of two doses (33 and 67 μg/kg/day) of growth hormone (GH) in short Japanese children born small for gestational age (SGA)...
  43. pmc Secondary metastasis in the lymph node of the bowel invaded by colon cancer: a report of three cases
    Aki Takiyama
    Department of Surgical Oncology, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    World J Surg Oncol 14:273. 2016
    ..Secondary metastasis to regional lymph nodes for adjacent bowel invaded by colorectal cancers (CRCs) has not been extensively reviewed. We herein present three such cases...
  44. doi Perforation of jejunal diverticulum with ectopic pancreas
    Hiroshi Shiratori
    Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, 3 1 Hongo 7 chome, Bunkyo ku, Tokyo, 113 8655, Japan
    Clin J Gastroenterol . 2017
    ..This rare case shows that the ectopic pancreas might have caused penetration of jejunal diverticulum owing to the pancreatic duct opening through the diverticulum...
  45. ncbi Survival and Prognostic Factors for Metachronous Peritoneal Metastasis in Patients with Colon Cancer
    Hiroshi Nagata
    Department of Surgical Oncology, The University of Tokyo, Bunkyo, Tokyo, Japan
    Ann Surg Oncol . 2016
    ..The clinical course of metachronous peritoneal metastasis of colorectal origin is poorly understood. In this retrospective study, we aimed to elucidate survival and prognostic factors for metachronous peritoneal metastasis...
  46. ncbi Anal metastasis from rectal adenocarcinoma
    Takeshi Nishikawa
    Department of Surgical Oncology, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Clin J Gastroenterol 9:379-383. 2016
    ..In the next procedure, she had the liver lesions resected. This case suggested the importance of the careful examination of the anus during colonoscopy, or digital examination for the detection of anal metastasis...
  47. pmc Late sacral recurrence of rectal cancer treated by heavy ion radiotherapy: a case report
    Hiroyuki Matsuzaki
    Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Surg Case Rep 2:109. 2016
    ..The need for surveillance of rare late recurrence of rectal cancer has not yet been established. Local control of unresectable skeletal metastasis is important for palliation of symptoms and support for systemic chemotherapy...
  48. ncbi Prognostic Value of Pre- and Postoperative Anti-p53 Antibody Levels in Colorectal Cancer Patients: A Retrospective Study
    Shinya Abe
    Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo Hospital, Tokyo, Japan
    Oncology . 2016
    ..To determine the utility of the post-/preoperative anti-p53 antibody (p53 Ab) ratio as a prognostic factor for colorectal cancer (CRC) recurrence...
  49. pmc High RAD54B expression: an independent predictor of postoperative distant recurrence in colorectal cancer patients
    Yuzo Nagai
    Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, Hongo, Bunkyo ku, Tokyo, Japan
    Oncotarget 6:21064-73. 2015
    ..This study first demonstrated RAD54B expression has potential to serve as a novel prognostic biomarker, particularly for distant recurrence in CRC patients. ..
  50. pmc A patient with gastric cancer with peritoneal carcinomatosis treated with intraperitoneal chemotherapy who survived more than 5 years receiving repeated laparoscopic examinations: a case report
    Hironori Yamaguchi
    Department of Surgical Oncology, The University of Tokyo, 7 3 1 Bunkyo ku, Hongo, Tokyo, 113 8655, Japan
    J Med Case Rep 10:14. 2016
    ..This is the first report of a case of a patient with gastric cancer with massive peritoneal metastasis treated with intraperitoneal administration of paclitaxel and repeated laparoscopic examinations who survived more than 5 years...
  51. doi Comparison of Functional Outcomes of Patients Who Underwent Hand-Sewn or Stapled Ileal Pouch-Anal Anastomosis for Ulcerative Colitis
    Hiroaki Ishii
    1 Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    Int Surg 100:1169-76. 2015
    ..Postoperative complications, functional outcomes, and long-term QOL were similar in patients who had received hand-sewn or stapled IPAA. ..
  52. doi Incidence and prognostic significance of positive peritoneal lavage in colorectal cancer
    Takeshi Nishikawa
    Department of Surgical Oncology, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Surg Today 45:1073-81. 2015
    ..However, the meaning of positive peritoneal lavage cytology in colorectal cancer is still controversial. The aim of this review is to evaluate the prognostic significance of positive peritoneal lavage cytology in colorectal cancer...
  53. doi Prognostic significance of the lymph node ratio in stage IV colorectal cancer patients who have undergone curative resection
    Tsuyoshi Ozawa
    Department of Surgical Oncology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo Bunkyo ku, Tokyo, 113 8655, Japan
    Ann Surg Oncol 22:1513-9. 2015
    ..The purpose of this study was to evaluate the prognostic impact of the LNR in Stage IV CRC patients who have undergone curative resection...
  54. doi Identification and functional characterization of two novel NPR2 mutations in Japanese patients with short stature
    Naoko Amano
    Department of Pediatrics N A, S N, T H, Keio University School of Medicine, Tokyo 160 8582, Japan Department of Pediatrics T M, Asahikawa Kosei General Hospital, Asahikawa 078 8211, Japan Department of Basic Sciences Y I, The Japanese Red Cross Hokkaido College of Nursing, Kitami 090 0011, Japan Tanaka Growth Clinic T T, Tokyo 158 0097, Japan Department of Medical Subspecialties S Y, National Center for Child Health and Development, Tokyo 157 0074, Japan Department of Pediatrics T O, Hamamatsu University School of Medicine, Hamamatsu 431 3125, Japan and Japan Growth Genome Consortium T M, Y I, T T, S Y, T O, T H
    J Clin Endocrinol Metab 99:E713-8. 2014
    ..Biallelic NPR2 mutations cause acromesomelic dysplasia, type Maroteaux, which is bone dysplasia characterized by severe short stature and short limbs. A monoallelic NPR2 mutation has been suggested to mildly impair long bone growth...
  55. doi Determination of biotin (vitamin H) by the high-performance affinity chromatography with a trypsin-treated avidin-bound column
    Kou Hayakawa
    Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Tokyo, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 869:93-100. 2008
    ..This affinity-chromatographic method for biotin determination was shown to be a robust and reliable and is well suited for biochemical and nutritional research...
  56. ncbi A nationwide attempt to standardize growth hormone assays
    Toshiaki Tanaka
    The GH and Its Related Factors Study Committee, The Foundation for Growth Science, Tokyo, Japan
    Horm Res 64:6-11. 2005
    ..As a result the diagnostic cut-off peak GH has changed from 10 to 6 ng/ml...
  57. ncbi Efficacy and safety of growth hormone treatment in children born small for gestational age in Japan
    Toshiaki Tanaka
    Tanaka Growth Clinic, Tokyo, Japan
    J Pediatr Endocrinol Metab 21:423-31. 2008
    ..Oral glucose tolerance tests indicated a mostly normal pattern of plasma glucose before and after 12-month GH treatment. The growth-promoting effect was significantly higher with GH treatment at 0.067 mg/kg/day...
  58. ncbi Trends in age and anthropometric data at start of growth hormone treatment for girls with Turner syndrome in Japan
    Tsuyoshi Isojima
    Clinical Research Center, National Center for Child Health and Development, Setagaya Ku, Tokyo, Japan
    Endocr J 55:1065-70. 2008
    ..25). We concluded that age and shortness at initiation of GH treatment had been improving over time. However, these favorable trends have not fully met the conditions recommended by international clinical guidelines for TS...
  59. pmc Perianal and Vulvar Extramammary Paget Disease: A Report of Six Cases and Mapping Biopsy of the Anal Canal
    Yuzo Nagai
    Department of Surgical Oncology, The University of Tokyo Hospital, Tokyo, Japan
    Ann Dermatol 28:624-628. 2016
    ..During the median follow-up period of 37.3 months, no local recurrence was observed in all patients. Our small case series suggest the usefulness of mapping biopsy of the anal canal for the treatment of perianal and vulvar EMPD...
  60. ncbi Continuing efforts to standardize measured serum growth hormone values in Japan
    Noriyuki Katsumata
    The Study Committee for GH and Its Related Factors, The Foundation for Growth Science, Tokyo, Japan
    Endocr J 63:933-936. 2016
    ..To deal with the discrepancies, we established a formula using a linear structural relationship model and were able to standardize the GH values. We propose to use the formula to diagnose GH deficiency and excess in Japan...
  61. pmc Metachronous tubulovillous and tubular adenomas of the anal canal
    Hiroaki Nozawa
    Department of Surgical Oncology, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Diagn Pathol 10:139. 2015
    ..Our case report underscores the importance of careful observations throughout colonoscopy to detect precancerous lesions, particularly in anatomically narrow segments. ..
  62. ncbi Phospholipase A2 Group III and Group X Have Opposing Associations with Prognosis in Colorectal Cancer
    Shinsuke Kazama
    Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Anticancer Res 35:2983-90. 2015
    ..Although secretory phospholipase A2 (sPLA2) has been shown to be involved in various biological processes, its specific roles in sub-types of cancer development remain to be elucidated...
  63. doi Prognostic impact of primary tumor resection and lymph node dissection in stage IV colorectal cancer with unresectable metastasis: a propensity score analysis in a multicenter retrospective study
    Soichiro Ishihara
    Department of Surgical Oncology, The University of Tokyo Hospital, Tokyo, Japan
    Ann Surg Oncol 21:2949-55. 2014
    ..Prognostic significance of lymph node dissection (LND) in mCRC has not been examined previously. The aim of this study was to investigate the prognostic impact of primary tumor resection and LND in mCRC...
  64. ncbi Growth hormone treatment in short Japanese children born small for gestational age
    Reiko Horikawa
    Division of Endocrinology and Metabolism, National Center for Child Health and Development, Tokyo, Japan
    Horm Res 62:128-36. 2004
    ..Careful observation is also necessary to assess the metabolic effects of high-dose GH, especially on carbohydrate metabolism...
  65. ncbi Loss of Smad4 protein expression and 18qLOH as molecular markers indicating lymph node metastasis in colorectal cancer--a study matched for tumor depth and pathology
    Toshiaki Tanaka
    Department of Surgical Oncology, University of Tokyo, 7 3 1 Hongo, Tokyo, Japan
    J Surg Oncol 97:69-73. 2008
    ..In this report, we studied the significance of chromosome 18q deletion and loss of Smad4 protein expression in association with lymph node metastasis...
  66. doi Inconsistent determination of overweight by two anthropometric indices in girls with Turner syndrome
    Tsuyoshi Isojima
    Clinical Research Center, National Center for Child Health and Development, Ohkura, Setagaya Ku, Tokyo, Japan
    Acta Paediatr 98:513-8. 2009
    ....
  67. doi Gene expression signature and the prediction of lymph node metastasis in colorectal cancer by DNA microarray
    Toshiaki Watanabe
    Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan
    Dis Colon Rectum 52:1941-8. 2009
    ..Our objective here was to identify a set of discriminating genes that can be used for characterization and prediction of lymph node metastasis...
  68. ncbi Hearing loss in Turner syndrome
    Noriko Morimoto
    Department of Otolaryngology, National Center for Child Health and Development, Tokyo, Japan
    J Pediatr 149:697-701. 2006
    ..To address the characteristics of hearing loss in patients with Turner syndrome (TS), we evaluated hearing levels of patients with TS and analyzed causative factors...
  69. ncbi The Third International Congress of the GRS and the IGF Society, November 11-15, 2006, Kobe, Japan
    Toshiaki Tanaka
    Department of Clinical Laboratory Medicine, National Center for Child Health and Development, Tokyo, Japan
    Pediatr Endocrinol Rev 4:362-5. 2007
  70. ncbi Nonclassic steroid 21-hydroxylase deficiency due to a homozygous V281L mutation in CYP21A2 detected by the neonatal mass-screening program in Japan
    Takashi Shinagawa
    Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Tokyo, Japan
    Endocr J 54:1021-5. 2007
    ....
  71. doi Analysis of weight at birth and at diagnosis of childhood-onset type 2 diabetes mellitus in Japan
    Shigetaka Sugihara
    Department of Pediatrics, Tokyo Women s Medical University Medical Center East, Tokyo, Japan
    Pediatr Diabetes 9:285-90. 2008
    ..We examined the associations of weight at birth, weight at diagnosis of T2DM, and clinical characteristics of childhood-onset T2DM...
  72. ncbi The 40th Annual Meeting of the Japanese Society for Pediatric Endocrinology (JSPE), Hamamatsu, Japan, 27-29 September 2006
    Toshiaki Tanaka
    Department of Clinical Laboratory Medicine, National Center for Child Health and Development, Tokyo, Japan
    Pediatr Endocrinol Rev 4:237-8. 2007
  73. ncbi Novel compound heterozygous AIRE mutations in a Japanese patient with APECED
    Utako Sato
    Division of Endocrinology and Metabolism, Department of Medicine, National Center for Child Health and Development, Tokyo, Japan
    J Pediatr Endocrinol Metab 17:917-21. 2004
    ..The other was a G-->A transition at IVS11+1. Her mother was heterozygous for 1471 delCinsTT and was normal homozygous for IVS11+1. We found novel compound heterozygous mutations in the AIRE gene of a Japanese female with APECED...
  74. doi Solid-phase total synthesis of the chitinase inhibitor Argadin using a supported acetal resin
    Tomoyasu Hirose
    The Kitasato Institute, Kitasato Institute for Life Science and Graduate School of Infection Control Sciences, Kitasato University, Minato ku, Tokyo, Japan
    J Antibiot (Tokyo) 62:495-500. 2009
    ....
  75. ncbi Results of long-term follow-up after treatment of central precocious puberty with leuprorelin acetate: evaluation of effectiveness of treatment and recovery of gonadal function. The TAP-144-SR Japanese Study Group on Central Precocious Puberty
    Toshiaki Tanaka
    Department of Endocrinology and Metabolism, National Center for Child Health and Development, 2 10 1, Okura, Setagaya, Tokyo, 157 8535, Japan
    J Clin Endocrinol Metab 90:1371-6. 2005
    ..Serum testosterone levels reached normal adult level in all boys. In conclusion, long-term leuprorelin treatment for children with CPP improved AH and had no adverse effects on recovery of reproductive function...
  76. ncbi Molecular genetic analysis of MODY candidate genes in Japanese patients with non-obese juvenile onset diabetes mellitus
    Masayo Kagami-Takasugi
    Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Tokyo, Japan
    J Pediatr Endocrinol Metab 19:143-8. 2006
    ..5%. The significance of the new promoter variant in the development of DM is unclear; however, a promoter mutation in the HNF-1alpha gene could be diabetogenic...
  77. doi Nuclear Notch3 expression is associated with tumor recurrence in patients with stage II and III colorectal cancer
    Tsuyoshi Ozawa
    Department of Surgical Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Ann Surg Oncol 21:2650-8. 2014
    ..In the present study, we investigated Notch1 and Notch3 expression in Stage II and III CRC to assess their association with clinicopathological characteristics...
  78. ncbi Replacement of alanine with asparagic acid at position 203 in human steroidogenic acute regulatory protein impairs the ability to enhance steroidogenesis in vitro
    Noriyuki Katsumata
    Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Tokyo, Japan
    Endocr J 53:427-31. 2006
    ..Together, these results indicate that the alanine at position 203 in human StAR is functionally important and that the D203 StAR is extremely unlikely to be a polymorphism...
  79. doi Salivary cortisol monitoring: determination of reference values in healthy children and application in asthmatic children
    Toshikazu Nagakura
    Yoga Allergy Clinic, Tokyo, Japan
    Allergy Asthma Proc 33:362-9. 2012
    ..Longer-term studies that incorporate testing of the hypothalamic-pituitary-adrenal axis are warranted to confirm our findings...
  80. ncbi Novel missense mutation in the P-box of androgen receptor in a patient with androgen insensitivity syndrome
    Noriyuki Katsumata
    Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Tokyo, Japan
    Endocr J 55:225-8. 2008
    ....
  81. ncbi Determination of specific activities and kinetic constants of biotinidase and lipoamidase in LEW rat and Lactobacillus casei (Shirota)
    Kou Hayakawa
    Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, 2 10 1 Okura, Setagaya Ku, Tokyo 157 8535, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 844:240-50. 2006
    ..Therefore, this HPLC determination method for the enzyme kinetic parameters in tissues is expected to be an indispensable tool for the investigation of the various diseases in humans...
  82. doi Critical role of farnesoid X receptor for hepatocellular carcinoma cell proliferation
    Tomofumi Fujino
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, Tokyo, Japan
    J Biochem 152:577-86. 2012
    ....
  83. ncbi Diagnosis and management of growth hormone deficiency in childhood and adolescence--part 2: growth hormone treatment in growth hormone deficient children
    Toshiaki Tanaka
    Department of Endocrinology and Metabolism, National Children s Medical Research Center, Tokyo, Japan
    Growth Horm IGF Res 12:323-41. 2002
  84. doi Novel functional hepatocyte cell line derived from spontaneous dwarf rat: model of growth hormone function in vitro
    Mayumi Ishikawa
    Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan
    Hum Cell 23:164-72. 2010
    ..In summary, we established a novel hepatocyte cell line (SDRL-1), that appears to display normal function, which we propose can serve as a good in vitro model for studying GH-target organ interactions...
  85. doi Total synthesis and determination of the absolute configuration of guadinomines B and C2
    Tomoyasu Hirose
    Kitasato Institute for Life Science, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo, 108 8641, Japan
    Chemistry 14:8220-38. 2008
    ..The novel feature of our method is an intramolecular S(N)2 cyclization that uses PPh(3) and I(2) to construct the unique 5-membered cyclic guanidine substructure...
  86. ncbi Left-Sided microsatellite unstable colorectal cancers show less frequent methylation of hMLH1 and CpG island methylator phenotype than right-sided ones
    Junichiro Tanaka
    Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan
    J Surg Oncol 96:611-8. 2007
    ..To the best of our knowledge, this is the first to report that left-sided CRCs show significantly less frequent methylation at several loci and CpG island methylator phenotype (CIMP) than right-sided ones...
  87. ncbi Genitourinary phenotype in XX patients with distal 9p monosomy
    Yoko Fujimoto
    Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Tokyo, Japan
    Mol Genet Metab 82:173-9. 2004
    ..In addition, it is possible that a gene(s) for anoperineal and renal development also maps distal to D9S168 and that for external genital development maps distal to D9S285 at the position approximately 16 Mb from the 9p telomere...
  88. ncbi Statural growth in 31 Japanese patients with SHOX haploinsufficiency: support for a disadvantageous effect of gonadal estrogens
    Maki Fukami
    Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Tokyo, Japan
    Endocr J 51:197-200. 2004
    ..8, P = 0.0060). The results imply that gonadal estrogens have a deleterious effect on pubertal growth in SHOX haploinsufficiency, and that the growth disadvantage is recognizable by longitudinal rather than cross-sectional growth studies...