Hsin Hou Chang

Summary

Affiliation: Tzu Chi University
Country: Taiwan

Publications

  1. doi request reprint Dengue virus and antiplatelet autoantibodies synergistically induce haemorrhage through Nlrp3-inflammasome and FcγRIII
    Te Sheng Lien
    Hsin Hou Chang, PhD, Department of Molecular Biology and Human Genetics, Tzu Chi University, Hualien 970, Taiwan, Republic of China, Tel 886 3 8565301 ext 2667, Fax 886 3 8578386, E mail
    Thromb Haemost 113:1060-70. 2015
  2. pmc The use of nanoscale visible light-responsive photocatalyst TiO2-Pt for the elimination of soil-borne pathogens
    Ya Lei Chen
    Department of Biotechnology, National Kaohsiung Normal University, Kaohsiung, Taiwan
    PLoS ONE 7:e31212. 2012
  3. ncbi request reprint Facilitation of cell adhesion by immobilized dengue viral nonstructural protein 1 (NS1): arginine-glycine-aspartic acid structural mimicry within the dengue viral NS1 antigen
    Hsin Hou Chang
    Institute of Molecular and Cellular Biology, Tzu Chi University, Hualien, and Institute of Preventive Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China
    J Infect Dis 186:743-51. 2002
  4. ncbi request reprint Cell-adhesion and morphological changes are not sufficient to support anchorage-dependent cell growth via non-integrin-mediated attachment
    Hsin Hou Chang
    Institute of Molecular and Cellular Biology, Tzu Chi University, Hualien 970, Taiwan, ROC
    Cell Biol Int 27:123-33. 2003
  5. ncbi request reprint Calcium oscillation and phosphatidylinositol 3-kinase positively regulate integrin alpha(IIb)beta3-mediated outside-in signaling
    Der Shan Sun
    Institute of Molecular and Cellular Biology, Tzu Chi University, Hualien, Taiwan
    J Biomed Sci 12:321-33. 2005
  6. pmc Visible-light-induced bactericidal activity of a nitrogen-doped titanium photocatalyst against human pathogens
    Ming Show Wong
    Department of Materials Science and Engineering, National Dong Hwa University, Hualien, Taiwan
    Appl Environ Microbiol 72:6111-6. 2006
  7. ncbi request reprint Single-step purification of recombinant anthrax lethal factor from periplasm of Escherichia coli
    Hsin Hou Chang
    Institute of Human Genetics, Tzu Chi University, No 701, Section 3, Chung Yang Road, Hualien 970, Taiwan, ROC
    J Biotechnol 126:277-85. 2006
  8. doi request reprint Visible light-responsive core-shell structured In₂O₃@CaIn₂O₄ photocatalyst with superior bactericidal properties and biocompatibility
    Wen Ku Chang
    Department of Materials Science and Engineering, National Dong Hwa University, Hualien, Taiwan, Republic of China
    Nanomedicine 8:609-17. 2012
  9. ncbi request reprint Antiplatelet activities of anthrax lethal toxin are associated with suppressed p42/44 and p38 mitogen-activated protein kinase pathways in the platelets
    Jyh Hwa Kau
    Institute of Preventive Medicine, National Defense Medical Center, Taipei, Taiwan
    J Infect Dis 192:1465-74. 2005
  10. ncbi request reprint PI3-kinase is essential for ADP-stimulated integrin alpha(IIb)beta3-mediated platelet calcium oscillation, implications for P2Y receptor pathways in integrin alpha(IIb)beta3-initiated signaling cross-talks
    Der Shan Sun
    Institute of Human Genetics, Tzu Chi University, Hualien 970, Taiwan, Republic of China
    J Biomed Sci 12:937-48. 2005

Collaborators

  • Chia Liang Cheng
  • Der Shan Sun
  • Jyh Hwa Kau
  • Chi Hung Lin
  • Nien Tsung Lin
  • Pei Jane Tsai
  • Jiann Hwa Chen
  • Wen sheng Wu
  • H Chan
  • C M Chang
  • Ya Lei Chen
  • Wun Ju Shieh
  • Chwan Chuen King
  • Ming Show Wong
  • Je Wen Liou
  • Hsuan Shun Huang
  • Po Kong Chen
  • Yao Hsuan Tseng
  • Chun Chieh Tseng
  • Te Sheng Lien
  • Hsin I Hu
  • Guan Ling Lin
  • Wen Ku Chang
  • Yu Chung Lin
  • Shu Rung Chang
  • Shih Lien Wang
  • Jui Chin Chang
  • Yun Hsuan Tsai
  • Kai Chih Chang
  • Anren Hu
  • Ming Shen Dai
  • Cheng Yeu Wu
  • Chia Chun Hsieh
  • Shu Hui Su
  • Chun Wei Chen
  • Shih Che Hung
  • You Yen Lin
  • Yi Ling Lai
  • Ming Chun Hsieh
  • Chi Yuan Liao
  • Ting Kai Lin
  • Han Chen Ho
  • Tsung Pao Wang
  • Ming Syuan Syue
  • Hsin Hsien Huang
  • Hui Ling Hsu
  • Lin Wei Tsai
  • Pai Tsang Huang
  • Elena Perevedentseva
  • Alexander Priezzhev
  • Andrei E Lugovtsov
  • Yi Hung Cheng
  • Jani Mona
  • Ming Hui Gu
  • Wen Yi Chen
  • Yu Jiun Hung
  • Lii Jia Yang
  • Yan Feng Lu
  • Yu Hsiang Lin
  • Kung Jiun Wang
  • Wei Jie Chen
  • Mei Shiuan Yu
  • Shang Feng Hsu
  • Wen Chen Chu
  • Szecheng J Lo

Detail Information

Publications36

  1. doi request reprint Dengue virus and antiplatelet autoantibodies synergistically induce haemorrhage through Nlrp3-inflammasome and FcγRIII
    Te Sheng Lien
    Hsin Hou Chang, PhD, Department of Molecular Biology and Human Genetics, Tzu Chi University, Hualien 970, Taiwan, Republic of China, Tel 886 3 8565301 ext 2667, Fax 886 3 8578386, E mail
    Thromb Haemost 113:1060-70. 2015
    ..These findings may provide new perspectives for developing feasible approaches to treat patients with DHF...
  2. pmc The use of nanoscale visible light-responsive photocatalyst TiO2-Pt for the elimination of soil-borne pathogens
    Ya Lei Chen
    Department of Biotechnology, National Kaohsiung Normal University, Kaohsiung, Taiwan
    PLoS ONE 7:e31212. 2012
    ..These findings suggest that the TiO(2)-Pt photocatalyst may have potential applications in the development of bactericides for soil-borne pathogens...
  3. ncbi request reprint Facilitation of cell adhesion by immobilized dengue viral nonstructural protein 1 (NS1): arginine-glycine-aspartic acid structural mimicry within the dengue viral NS1 antigen
    Hsin Hou Chang
    Institute of Molecular and Cellular Biology, Tzu Chi University, Hualien, and Institute of Preventive Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China
    J Infect Dis 186:743-51. 2002
    ..In addition, anti-NS1 antibodies blocked RGD-mediated cell adhesion. Although there is no RGD motif in the NS1 protein sequence, these data indicate that RGD structural mimicry exists within the NS1 antigen...
  4. ncbi request reprint Cell-adhesion and morphological changes are not sufficient to support anchorage-dependent cell growth via non-integrin-mediated attachment
    Hsin Hou Chang
    Institute of Molecular and Cellular Biology, Tzu Chi University, Hualien 970, Taiwan, ROC
    Cell Biol Int 27:123-33. 2003
    ..This provides a different perspective for the study of the relationships between the cell-morphological change and the cell-survival signal...
  5. ncbi request reprint Calcium oscillation and phosphatidylinositol 3-kinase positively regulate integrin alpha(IIb)beta3-mediated outside-in signaling
    Der Shan Sun
    Institute of Molecular and Cellular Biology, Tzu Chi University, Hualien, Taiwan
    J Biomed Sci 12:321-33. 2005
    ....
  6. pmc Visible-light-induced bactericidal activity of a nitrogen-doped titanium photocatalyst against human pathogens
    Ming Show Wong
    Department of Materials Science and Engineering, National Dong Hwa University, Hualien, Taiwan
    Appl Environ Microbiol 72:6111-6. 2006
    ..These findings suggest that nitrogen-doped TiO(2) has potential application in the development of alternative disinfectants for environmental and medical usages...
  7. ncbi request reprint Single-step purification of recombinant anthrax lethal factor from periplasm of Escherichia coli
    Hsin Hou Chang
    Institute of Human Genetics, Tzu Chi University, No 701, Section 3, Chung Yang Road, Hualien 970, Taiwan, ROC
    J Biotechnol 126:277-85. 2006
    ..These findings suggested that the purification protocol herein is a user-friendly method that allows researchers to obtain the functional rLF by single-step purification...
  8. doi request reprint Visible light-responsive core-shell structured In₂O₃@CaIn₂O₄ photocatalyst with superior bactericidal properties and biocompatibility
    Wen Ku Chang
    Department of Materials Science and Engineering, National Dong Hwa University, Hualien, Taiwan, Republic of China
    Nanomedicine 8:609-17. 2012
    ..These findings suggest that In(2)O(3)@CaIn(2)O(4) may have potential application in the development of a safer and highly bactericidal photocatalyst...
  9. ncbi request reprint Antiplatelet activities of anthrax lethal toxin are associated with suppressed p42/44 and p38 mitogen-activated protein kinase pathways in the platelets
    Jyh Hwa Kau
    Institute of Preventive Medicine, National Defense Medical Center, Taipei, Taiwan
    J Infect Dis 192:1465-74. 2005
    ..Combined treatments with LT and antiplatelet agents such as aspirin and the RGD-containing disintegrin rhodostomin significantly increased mortality in mice. Our data suggest that platelets are a pathogenic target for anthrax LT...
  10. ncbi request reprint PI3-kinase is essential for ADP-stimulated integrin alpha(IIb)beta3-mediated platelet calcium oscillation, implications for P2Y receptor pathways in integrin alpha(IIb)beta3-initiated signaling cross-talks
    Der Shan Sun
    Institute of Human Genetics, Tzu Chi University, Hualien 970, Taiwan, Republic of China
    J Biomed Sci 12:937-48. 2005
    ..Our data indicates the important roles of PI3K and granular released ADP in coordinating the feedback regulations in integrin alpha(IIb)beta3-mediated platelet activation...
  11. pmc Erythrocytic mobilization enhanced by the granulocyte colony-stimulating factor is associated with reduced anthrax-lethal-toxin-induced mortality in mice
    Hsin Hou Chang
    Department of Molecular Biology and Human Genetics, Tzu Chi University, Hualien, Taiwan Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan
    PLoS ONE 9:e111149. 2014
    ..anthracis-spore-elicited mortality in mice. Although specific treatments against LT-mediated pathogenesis remain elusive, these results may be useful in developing feasible strategies to treat anthrax. ..
  12. pmc Sublethal doses of anthrax lethal toxin on the suppression of macrophage phagocytosis
    Jyh Hwa Kau
    Institute of Preventive Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China
    PLoS ONE 5:e14289. 2010
    ..Determining whether LT exerts any pathological effects before being enriched to an MEK inhibitory level is an important next step in the furtherance of this field...
  13. doi request reprint Antibacterial performance of nanoscaled visible-light responsive platinum-containing titania photocatalyst in vitro and in vivo
    Yao Hsuan Tseng
    Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan
    Biochim Biophys Acta 1830:3787-95. 2013
    ..However, its physical and photocatalytic properties, and the application in vivo have not been well-characterized...
  14. doi request reprint Dendritic cells modulate platelet activity in IVIg-mediated amelioration of ITP in mice
    Hsuan Shun Huang
    Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan, Republic of China
    Blood 116:5002-9. 2010
    ..As platelets are a component of DC regulatory circuits, these findings may suggest an alternative perspective for the use of IVIg treatment...
  15. pmc Activated protein C ameliorates Bacillus anthracis lethal toxin-induced lethal pathogenesis in rats
    Jyh Hwa Kau
    Institute of Preventive Medicine, National Defense Medical Center, Taipei, Taiwan, ROC
    J Biomed Sci 19:98. 2012
    ..Coagulopathy may contribute to circulatory failure and lung injury. However, the effect of LT on coagulation-induced lung dysfunction is unclear...
  16. doi request reprint Bactericidal effects and mechanisms of visible light-responsive titanium dioxide photocatalysts on pathogenic bacteria
    Je Wen Liou
    Department of Biochemistry, School of Medicine, Tzu Chi University, Hualien, Taiwan, ROC
    Arch Immunol Ther Exp (Warsz) 60:267-75. 2012
    ..These photocatalysts, thus, provide a promising and feasible approach for disinfection of pathogenic bacteria; facilitating the prevention of infectious diseases...
  17. pmc Bactericidal performance of visible-light responsive titania photocatalyst with silver nanostructures
    Ming Show Wong
    Department of Materials Science and Engineering, National Dong Hwa University, Hualien, Taiwan
    PLoS ONE 5:e10394. 2010
    ..The antibacterial efficiency, however, remains to be further improved...
  18. pmc Erythropoiesis suppression is associated with anthrax lethal toxin-mediated pathogenic progression
    Hsin Hou Chang
    Department of Molecular Biology and Human Genetics, Tzu Chi University, Hualien, Taiwan Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan
    PLoS ONE 8:e71718. 2013
    ..Because specific treatments to overcome LT-mediated pathogenesis are still lacking, these efforts may help the development of effective treatments against anthrax. ..
  19. doi request reprint Endothelial Cell Sensitization by Death Receptor Fractions of an Anti-Dengue Nonstructural Protein 1 Antibody Induced Plasma Leakage, Coagulopathy, and Mortality in Mice
    Der Shan Sun
    Department of Molecular Biology and Human Genetics, Tzu Chi University, Hualien 970, Taiwan
    J Immunol 195:2743-53. 2015
    ..Detecting and blocking anti-DR Igs in patients may be novel strategies for managing severe DENV infection. ..
  20. pmc Visible light responsive photocatalyst induces progressive and apical-terminus preferential damages on Escherichia coli surfaces
    Je Wen Liou
    Department of Biochemistry, Tzu Chi University, Hualien, Taiwan, Republic of China
    PLoS ONE 6:e19982. 2011
    ..Recent research shows that visible-light responsive photocatalysts have potential usage in antimicrobial applications. However, the dynamic changes in the damage to photocatalyzed bacteria remain unclear...
  21. doi request reprint Cell adhesion as a novel approach to determining the cellular binding motif on the severe acute respiratory syndrome coronavirus spike protein
    Hsin Hou Chang
    Department of Molecular Biology and Human Genetics, Tzu Chi University, Hualien, Taiwan Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan
    J Virol Methods 201:1-6. 2014
    ..Following analyses, 2 peptides spanning the 436-445 and 437-461 amino acids of the spike protein were identified as peptide inhibitor or peptide vaccine candidates against SARS-CoV. ..
  22. doi request reprint The influence of nanodiamond on the oxygenation states and micro rheological properties of human red blood cells in vitro
    Yu Chung Lin
    Department of Physics, National Dong Hwa University, Hualien 97401, Taiwan
    J Biomed Opt 17:101512. 2012
    ..However, controlling the blood properties including deformability of RBCs and rheological properties of blood is necessary during treatment...
  23. doi request reprint Soluble P-selectin rescues mice from anthrax lethal toxin-induced mortality through PSGL-1 pathway-mediated correction of hemostasis
    Der Shan Sun
    a Department of Molecular Biology and Human Genetics, Tzu Chi University, Hualien 970, Taiwan
    Virulence . 2017
    ..These results suggest that the administration of sP-sel is likely to be useful in the development of a new strategy to treat anthrax...
  24. doi request reprint Megakaryocytic differentiation of mouse embryonic stem cells via coculture with immortalized OP9 stromal cells
    Po Kong Chen
    Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan
    Exp Cell Res 339:44-50. 2015
    ....
  25. pmc The effects of the bacterial interaction with visible-light responsive titania photocatalyst on the bactericidal performance
    Chia Liang Cheng
    Department of Physics, National Dong Hwa University, Hualien, Taiwan
    J Biomed Sci 16:7. 2009
    ..These findings suggest the created materials with high bacterial interaction ability might be a useful strategy to improve the antimicrobial activity of visible-light-activated TiO2...
  26. doi request reprint Platelets in inflammation and immune modulations: functions beyond hemostasis
    Hsuan Shun Huang
    Department of Molecular Biology and Human Genetics, Tzu Chi University, 701 Sec 3, Chung Yang Rd, Hualien, 970, Taiwan, ROC
    Arch Immunol Ther Exp (Warsz) 60:443-51. 2012
    ..The cross-talks between these two systems implicate that platelet therapy may have application beyond thrombosis, and immune interventions may have potentials to treat thrombosis diseases...
  27. pmc Suppressive effects of anthrax lethal toxin on megakaryopoiesis
    Po Kong Chen
    Institute of Medical Science, Tzu Chi University, Hualien, Taiwan
    PLoS ONE 8:e59512. 2013
    ..These results suggest that megakaryocytic suppression is one of the mechanisms by which LT induces thrombocytopenia. These findings may provide new insights for developing feasible approaches against anthrax...
  28. ncbi request reprint Differential regulation of JNK in caspase-3-mediated apoptosis of MPP(+)-treated primary cortical neurons
    Der Shan Sun
    Institute of Human Genetics, Tzu Chi University, 970 Hualien, Taiwan, ROC
    Cell Biol Int 27:769-77. 2003
    ..Interestingly, JNK activity increased in untreated cultures over time, whereas it was down-regulated after MPP(+)treatment. This indicates that the JNK pathways could be differentially regulated in different apoptotic processes...
  29. doi request reprint Altered susceptibility to the bactericidal effect of photocatalytic oxidation by TiO2 is related to colistin resistance development in Acinetobacter baumannii
    Chun Chieh Tseng
    Department and Graduate Institute of Public Health, Tzu Chi University, Hualien, Taiwan
    Appl Microbiol Biotechnol 100:8549-61. 2016
    ..Therefore, the antibiotic resistance profiles of bacterial strains should be considered before the use of strains as indicators to represent sanitary quality after TiO2 photocatalysis. ..
  30. pmc Soluble P-selectin rescues viper venom-induced mortality through anti-inflammatory properties and PSGL-1 pathway-mediated correction of hemostasis
    Der Shan Sun
    Department of Molecular Biology and Human Genetics, Tzu Chi University, Hualien 970, Taiwan
    Sci Rep 6:35868. 2016
    ..Our data suggest that the elevation of endogenous sP-sel level is a self-protective response against venom-suppressed coagulation. The administration of recombinant sP-sel may be developed as a new strategy to treat Viperidae snakebites...
  31. pmc Antibacterial property of Ag nanoparticle-impregnated N-doped titania films under visible light
    Ming Show Wong
    1 Department of Materials Science and Engineering, National Dong Hwa University, Hualien, Taiwan 2 Nanotechnology Research Center, National Dong Hwa University, Hualien, Taiwan
    Sci Rep 5:11978. 2015
    ..This study demonstrated a feasible approach to improve the visible-light responsiveness and durability of antibacterial materials that contain silver nanoparticles impregnated in TiO2(N) films. ..
  32. doi request reprint Differential regulation of caspase-2 in MPP⁺-induced apoptosis in primary cortical neurons
    Hsin I Hu
    Department of Molecular Biology and Human Genetics, Tzu Chi University, No 701, Section 3, Zhong Yang Road, 97004 Hualien, Taiwan, ROC
    Exp Cell Res 332:60-6. 2015
    ..We demonstrated that caspase-2 activation is specific to MPP(+)-induced apoptosis and occurs before Bax translocation to the mitochondria. Caspase-2 activation is one of the few early molecular events identified in PD models...
  33. ncbi request reprint The integrin alpha6beta1 modulation of PI3K and Cdc42 activities induces dynamic filopodium formation in human platelets
    Jui Chin Chang
    Institute of Microbiology and Immunology, National Yang Ming University, Taipei, 112, Taiwan
    J Biomed Sci 12:881-98. 2005
    ..Taken together, this study demonstrates that the signals induced by integrin alpha6beta1 modulate at the level of PI3K and Cdc42 activity to allow platelets to actively form filopodia...
  34. pmc Alteration of the phenotypic and pathogenic patterns of Burkholderia pseudomallei that persist in a soil environment
    Yao Shen Chen
    Division of Infectious Diseases, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan Graduate Institute of Science Education and Environmental Education, National Kaohsiung Normal University, Kaohsiung Taiwan Department of Internal Medicine, National Yang Ming University, Taipei, Taiwan Infectious Diseases Pathology Branch, Centers for Disease Control and Prevention, Atlanta, Georgia Department of Molecular Biology and Human Genetics, Tzu Chi University, Hualien, Taiwan Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan Department of Biotechnology, National Kaohsiung Normal University, Kaoshiung, Taiwan
    Am J Trop Med Hyg 90:469-79. 2014
    ..We suggest that specific phenotypic and pathogenic patterns can be induced through infection with B. pseudomallei that has been cultured in different (soil versus mouse) environments...
  35. pmc Role of visible light-activated photocatalyst on the reduction of anthrax spore-induced mortality in mice
    Jyh Hwa Kau
    Institute of Preventive Medicine, National Defense Medical Center, Taipei, Taiwan
    PLoS ONE 4:e4167. 2009
    ..Their anti-spore activity against Bacillus anthracis, however, remains to be investigated. We evaluated these visible-light activated photocatalysts on the reduction of anthrax spore-induced pathogenesis...
  36. pmc Characterization of early gamma interferon (IFN-gamma) expression during murine listeriosis: identification of NK1.1+ CD11c+ cells as the primary IFN-gamma-expressing cells
    Shu Rung Chang
    Department of Public Health, Tzu Chi University, Hualien 970, Taiwan
    Infect Immun 75:1167-76. 2007
    ..monocytogenes. Our findings not only provide an insight into IFN-gamma expression after in vivo infection but may also change the current perceptions of DC and natural killer cells...