Diahn Warng Perng

Summary

Affiliation: Taipei Veterans General Hospital
Country: Taiwan

Publications

  1. ncbi request reprint Inhaled fluticasone and salmeterol suppress eosinophilic airway inflammation in chronic obstructive pulmonary disease: relations with lung function and bronchodilator reversibility
    Diahn Warng Perng
    Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Lung 184:217-22. 2006
  2. doi request reprint Matrix metalloprotease-9 induces transforming growth factor-β(1) production in airway epithelium via activation of epidermal growth factor receptors
    Diahn Warng Perng
    Department of Chest Medicine, Taipei Veterans General Hospital, Taiwan
    Life Sci 89:204-12. 2011
  3. pmc miRNA-146a expression positively regulates tumor necrosis factor-α-induced interleukin-8 production in mesenchymal stem cells and differentiated lung epithelial-like cells
    Diahn Warng Perng
    Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Tissue Eng Part A 18:2259-67. 2012
  4. doi request reprint Long-acting β2 agonists and corticosteroids restore the reduction of histone deacetylase activity and inhibit H2O2-induced mediator release from alveolar macrophages
    Diahn Warng Perng
    Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    Pulm Pharmacol Ther 25:312-8. 2012
  5. ncbi request reprint Neutrophil elastase stimulates human airway epithelial cells to produce PGE2 through activation of p44/42 MAPK and upregulation of cyclooxygenase-2
    Diahn Warng Perng
    Dept of Chest Medicine, Taipei Veterans General Hospital, 201, Section 2, Shih Pai Rd, Taipei 11217, Taiwan
    Am J Physiol Lung Cell Mol Physiol 285:L925-30. 2003
  6. doi request reprint Anti-inflammatory effects of salmeterol/fluticasone, tiotropium/fluticasone or tiotropium in COPD
    D W Perng
    Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Eur Respir J 33:778-84. 2009
  7. doi request reprint Bile acids induce CCN2 production through p38 MAP kinase activation in human bronchial epithelial cells: a factor contributing to airway fibrosis
    Diahn Warng Perng
    1Department of Chest Medicine, 3School of Medicine, National Yang Ming University, Taipei, Taiwan
    Respirology 13:983-9. 2008
  8. ncbi request reprint Exposure of airway epithelium to bile acids associated with gastroesophageal reflux symptoms: a relation to transforming growth factor-beta1 production and fibroblast proliferation
    Diahn Warng Perng
    Department of Chest Medicine, Taipei Veterans General Hospital and School of Medicine, Nathional Yang Ming University, 201, Section 2, Shih Pai Rd, Taipei 11217, Taiwan
    Chest 132:1548-56. 2007
  9. ncbi request reprint Additive benefits of tiotropium in COPD patients treated with long-acting beta agonists and corticosteroids
    Diahn Warng Perng
    Department of Chest Medicine, Taipei Veterans General Hospital, 201 Shih Pai Road Section 2, Taipei 11217, Taiwan
    Respirology 11:598-602. 2006
  10. ncbi request reprint Leukotriene C4 induces TGF-beta1 production in airway epithelium via p38 kinase pathway
    Diahn Warng Perng
    Department of Chest Medicine, Taipei Veterans General Hospital, 201, Section 2, Shih Pai Road, Taipei 11217, Taiwan
    Am J Respir Cell Mol Biol 34:101-7. 2006

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Inhaled fluticasone and salmeterol suppress eosinophilic airway inflammation in chronic obstructive pulmonary disease: relations with lung function and bronchodilator reversibility
    Diahn Warng Perng
    Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Lung 184:217-22. 2006
    ..Suppression of eosinophilic inflammation and bronchodilator responsiveness indices were not correlated with clinical outcomes in COPD patients treated with inhaled corticosteroids/long-acting beta(2) agonists...
  2. doi request reprint Matrix metalloprotease-9 induces transforming growth factor-β(1) production in airway epithelium via activation of epidermal growth factor receptors
    Diahn Warng Perng
    Department of Chest Medicine, Taipei Veterans General Hospital, Taiwan
    Life Sci 89:204-12. 2011
    ..We hypothesized that MMP-9 may stimulate the airway epithelium to produce fibrogenic mediators through activation of membrane-bound receptors...
  3. pmc miRNA-146a expression positively regulates tumor necrosis factor-α-induced interleukin-8 production in mesenchymal stem cells and differentiated lung epithelial-like cells
    Diahn Warng Perng
    Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Tissue Eng Part A 18:2259-67. 2012
    ..The expression of miRNA-146a and the response to stimuli may be modulated through mature differentiation of BM-MSC...
  4. doi request reprint Long-acting β2 agonists and corticosteroids restore the reduction of histone deacetylase activity and inhibit H2O2-induced mediator release from alveolar macrophages
    Diahn Warng Perng
    Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    Pulm Pharmacol Ther 25:312-8. 2012
    ..The mechanisms of the anti-inflammatory effects and their associations with histone deacetylase (HDAC) activity remain unclear...
  5. ncbi request reprint Neutrophil elastase stimulates human airway epithelial cells to produce PGE2 through activation of p44/42 MAPK and upregulation of cyclooxygenase-2
    Diahn Warng Perng
    Dept of Chest Medicine, Taipei Veterans General Hospital, 201, Section 2, Shih Pai Rd, Taipei 11217, Taiwan
    Am J Physiol Lung Cell Mol Physiol 285:L925-30. 2003
    ..The airway epithelium may play important bronchoprotective and immunomodulatory roles in chronic neutrophilic inflammation...
  6. doi request reprint Anti-inflammatory effects of salmeterol/fluticasone, tiotropium/fluticasone or tiotropium in COPD
    D W Perng
    Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Eur Respir J 33:778-84. 2009
    ..The anti-inflammatory effects of salmeterol/fluticasone probably contribute to the clinical benefits seen in chronic obstructive pulmonary disease patients...
  7. doi request reprint Bile acids induce CCN2 production through p38 MAP kinase activation in human bronchial epithelial cells: a factor contributing to airway fibrosis
    Diahn Warng Perng
    1Department of Chest Medicine, 3School of Medicine, National Yang Ming University, Taipei, Taiwan
    Respirology 13:983-9. 2008
    ....
  8. ncbi request reprint Exposure of airway epithelium to bile acids associated with gastroesophageal reflux symptoms: a relation to transforming growth factor-beta1 production and fibroblast proliferation
    Diahn Warng Perng
    Department of Chest Medicine, Taipei Veterans General Hospital and School of Medicine, Nathional Yang Ming University, 201, Section 2, Shih Pai Rd, Taipei 11217, Taiwan
    Chest 132:1548-56. 2007
    ..Airway epithelial cells can release growth factors that promote fibroblast proliferation. Exposure of airway epithelium to bile acids may induce a fibrotic response...
  9. ncbi request reprint Additive benefits of tiotropium in COPD patients treated with long-acting beta agonists and corticosteroids
    Diahn Warng Perng
    Department of Chest Medicine, Taipei Veterans General Hospital, 201 Shih Pai Road Section 2, Taipei 11217, Taiwan
    Respirology 11:598-602. 2006
    ....
  10. ncbi request reprint Leukotriene C4 induces TGF-beta1 production in airway epithelium via p38 kinase pathway
    Diahn Warng Perng
    Department of Chest Medicine, Taipei Veterans General Hospital, 201, Section 2, Shih Pai Road, Taipei 11217, Taiwan
    Am J Respir Cell Mol Biol 34:101-7. 2006
    ..Early intervention to stop these processes may be useful in preventing airway fibrosis in chronic allergic inflammation...
  11. ncbi request reprint Pulmonary infiltrates with eosinophilia induced by nimesulide in an asthmatic patient
    Diahn Warng Perng
    Department of Chest Medicine, Taipei Veterans General Hospital, 201 Section 2 Shih Pai Road, Taipei 11217, Taiwan, ROC
    Respiration 72:651-3. 2005
    ..Nimesulide, though it is a relatively safe drug to use in aspirin-sensitive asthmatics, may (like other nonsteroidal anti-inflammatory drugs) cause PIE in asthmatic patients and thus should be used cautiously...
  12. ncbi request reprint Characteristics of airway inflammation and bronchodilator reversibility in COPD: a potential guide to treatment
    Diahn Warng Perng
    School of Medicine, National Yang Ming University, Taipei, Taiwan
    Chest 126:375-81. 2004
    ..Factors related to airway inflammation and bronchodilator reversibility may be important in the management of stable COPD patients...
  13. ncbi request reprint Leukotriene modifier vs inhaled corticosteroid in mild-to-moderate asthma: clinical and anti-inflammatory effects
    Diahn Warng Perng
    Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Chest 125:1693-9. 2004
    ....
  14. doi request reprint The suppression effects of thalidomide on human lung fibroblasts: cell proliferation, vascular endothelial growth factor release, and collagen production
    Ching Min Tseng
    Department of Chest Medicine, Taipei Veterans General Hospital, 201, Section 2, Shih Pai Road, Taipei, 11217, Taiwan
    Lung 191:361-8. 2013
    ....
  15. doi request reprint Bile acids increase alveolar epithelial permeability via mitogen-activated protein kinase, cytosolic phospholipase A2 , cyclooxygenase-2, prostaglandin E2 and junctional proteins
    Kang Cheng Su
    Institute of Emergency and Critical Care Medicine, School of Medicine, Taipei, Taiwan
    Respirology 18:848-56. 2013
    ..Bile acid (BA) aspiration is associated with various lung diseases. It was hypothesized that BA may induce changes in alveolar epithelium permeability and contribute to the pathogenesis of lung injury...
  16. doi request reprint Hospital outcomes for patients with stage III and IV lung cancer admitted to the intensive care unit for sepsis-related acute respiratory failure
    Kun Ta Chou
    Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    J Palliat Med 15:1234-9. 2012
    ..However, not all cancer patients would benefit from aggressive care, especially those with late-stage cancer...
  17. doi request reprint Bile acid aspiration in suspected ventilator-associated pneumonia
    Yu Chung Wu
    Division of Thoracic Surgery, Taipei Veterans General Hospital, Taipei, Taiwan
    Chest 136:118-24. 2009
    ....
  18. pmc Sleep Apnea and Risk of Panic Disorder
    Vincent Yi Fong Su
    Center of Sleep Medicine, Taipei Veterans General Hospital, Taipei, Taiwan Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan School of Medicine, National Yang Ming University, Taipei, Taiwan Institute of Clinical Medicine, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Ann Fam Med 13:325-30. 2015
    ..Epidemiological studies have identified a trend in the development of depressive and anxiety disorders following a diagnosis of sleep apnea. The relationship between sleep apnea and subsequent panic disorder, however, remains unclear...
  19. doi request reprint Adult narcoleptic patients have increased risk of cancer: A nationwide population-based study
    Ching Min Tseng
    Division of Respiratory Therapy, Department of Medicine, Cheng Hsin General Hospital, Taipei, Taiwan School of Medicine, National Yang Ming University, Taipei, Taiwan
    Cancer Epidemiol 39:793-7. 2015
    ..The comorbidity profile, especially cancer risk, of narcoleptic patients has seldom been explored. We used a nationwide database to evaluate the risk of cancer among adult narcoleptic patients...
  20. pmc Sleep disorders and increased risk of autoimmune diseases in individuals without sleep apnea
    Yi Han Hsiao
    Center of Sleep Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Sleep 38:581-6. 2015
    ..To explore the association between the non-apnea sleep disorder (NSD) and autoimmune diseases...
  21. doi request reprint Spontaneous breathing trial needs to be prolonged in critically ill and older patients requiring mechanical ventilation
    Kang Cheng Su
    Department of Chest Medicine, Taipei Veterans General Hospital, Taipei City, 112 Taiwan
    J Crit Care 27:324.e1-7. 2012
    ..To investigate a modified weaning procedure to predict extubation outcome in critically older and ventilated patients...
  22. doi request reprint The roles of transforming growth factor-β₁ and vascular endothelial growth factor in the tracheal granulation formation
    Yu Chin Lee
    Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan School of Medicine, National Yang Ming University, Taipei, Taiwan
    Pulm Pharmacol Ther 24:23-31. 2011
    ..The aim of this study was to investigate the mechanisms of tracheal granulation formation and find the potential therapeutic targets to prevent the granulation formation...
  23. doi request reprint Amyloidosis and the risk of cancer: a nationwide population-based study
    Vincent Yi Fong Su
    Department of Chest Medicine, Taipei Veterans General Hospital, No 201, Sec 2, Shih Pai Road, Taipei, 112, Taiwan
    Int J Clin Oncol 20:1244-51. 2015
    ..The association between amyloidosis and cancer remains unclear...
  24. doi request reprint Sleep apnoea patients have higher mortality when confronting sepsis
    Chien Yu Huang
    Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan Department of Medicine, Taipei Hospital, Ministry of Health and Welfare, Taipei, Taiwan
    Eur J Clin Invest 44:38-45. 2014
    ..This case-control study aimed to compare the outcomes of sepsis patients with and without sleep apnoea...
  25. doi request reprint Budesonide/formoterol combination as a maintenance and rescue therapy: physicians' perspectives
    Kang Cheng Su
    Chest Department, Taipei Veterans General Hospital, Taipei, Taiwan
    J Asthma 46:647-51. 2009
    ..To investigate the rationale of clinicians when treating asthmatics with combined budesonide/formoterol in a single inhaler as a maintenance and rescue therapy (BFMRT)...
  26. pmc Carvedilol, Bisoprolol, and Metoprolol Use in Patients With Coexistent Heart Failure and Chronic Obstructive Pulmonary Disease
    Vincent Yi Fong Su
    From the Department of Chest Medicine VY FS, K TC, K YY, D WP Cancer Center Y WH Division of Hematology and Oncology M HH, C JL Division of Nephrology S MO Division of Gastroenterology, Department of Medicine F YL Department of Family Medicine, Taipei Veterans General Hospital, Taipei T JC Division of Allergy, Immunology and Rheumatology, Department of Medicine, Taipei Medical University Shuang Ho Hospital, New Taipei City Y SC School of Medicine VY FS, Y SC, Y WH, M HH, S MO, F YL, K TC, K YY, D WP, T JC, C JL Institute of Public Health M HH, C JL and Institute of Clinical Medicine VY FS, K TC, National Yang Ming University, Taipei, Taiwan
    Medicine (Baltimore) 95:e2427. 2016
    ..001) and bisoprolol (57.9 vs 70.8 DDDs/person-year, P < 0.001). In patients with coexisting HF and COPD, this study demonstrated a dose-response survival benefit of bisoprolol use, but not of carvedilol or metoprolol use. ..
  27. doi request reprint Nocturnal stem cell mobilization in patients with obstructive sleep apnoea: a pilot study
    Kun Ta Chou
    Institute of Clinical Medicine, School of Medicine, National Yang Ming University, Taipei, Taiwan Faculty of Medicine, School of Medicine, National Yang Ming University, Taipei, Taiwan Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Eur J Clin Invest 44:1189-96. 2014
    ..These insults may damage the vasculature and provoke the corresponding repair response, such as stem cell mobilization to peripheral blood. This study aimed to investigate nocturnal mobilization of stem cells in OSA...
  28. doi request reprint Exhaled nitric oxide predicts eosinophilic airway inflammation in COPD
    Kun Ta Chou
    Department of Chest Medicine, Taipei Veterans General Hospital, No 201, Sec 2, Shi Pai Road, Taipei, 112, Taiwan
    Lung 192:499-504. 2014
    ..The role of exhaled nitric oxide (eNO) in identifying COPD patients with sputum eosinophilia was examined in this study...
  29. ncbi request reprint Mold allergen, pen C 13, induces IL-8 expression in human airway epithelial cells by activating protease-activated receptor 1 and 2
    Li Li Chiu
    Graduate Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Immunol 178:5237-44. 2007
    ..These finding show that Pen c 13 induces IL-8 release in airway epithelial cells and that this is dependent on PAR-1 and PAR-2 activation and intracellular calcium...
  30. doi request reprint Inflammatory role of AMP-activated protein kinase signaling in an experimental model of toxic smoke inhalation injury
    Diahn Warng Perng
    Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Crit Care Med 41:120-32. 2013
    ..We investigated the signaling pathway responsible for the induction of interleukin 8 by wood smoke extract in lung epithelial cells and lung inflammation induced by wood smoke exposure in mice...
  31. pmc Lung Epithelial TRPA1 Transduces the Extracellular ROS into Transcriptional Regulation of Lung Inflammation Induced by Cigarette Smoke: The Role of Influxed Ca²⁺
    An Hsuan Lin
    Department of Physiology, School of Medicine, National Yang Ming University, Taipei 11221, Taiwan
    Mediators Inflamm 2015:148367. 2015
    ..This mechanism may possibly be at work in mice chronically exposed to CS. ..
  32. pmc The effect of cold temperature on increased exacerbation of chronic obstructive pulmonary disease: a nationwide study
    Ching Min Tseng
    Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    PLoS ONE 8:e57066. 2013
    ..Seasonal variations in the acute exacerbation of chronic obstructive pulmonary disease (COPD) have been reported. However, the influence of air temperature and other meteorological factors on COPD exacerbation remains unclear...
  33. doi request reprint Sleep apnea and risk of retinal vein occlusion: a nationwide population-based study of Taiwanese
    Kun Ta Chou
    Department of Chest, Taipei Veterans General Hospital, Taipei, Taiwan
    Am J Ophthalmol 154:200-205.e1. 2012
    ..To explore the relationship of sleep apnea and the subsequent development of retinal vein occlusion (RVO)...
  34. doi request reprint Analysis of prescription pattern and guideline adherence in the management of asthma among medical institutions and physician specialties in Taiwan between 2000 and 2010
    Chia Lin Chou
    Department of Pharmacy, Taipei Veterans General Hospital, Taipei, Taiwan
    Clin Ther 37:2275-85. 2015
    ....
  35. ncbi request reprint Tryptase-stimulated human airway smooth muscle cells induce cytokine synthesis and mast cell chemotaxis
    Patrick Berger
    Laboratoire de Physiologie Cellulaire Respiratoire, INSERM E0356, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    FASEB J 17:2139-41. 2003
    ..HASMCs may thus be able to stimulate the accumulation of mast cells, and these cells may, in turn, stimulate the secretion of chemotactic factors by HASMCs...