Hsiu Chih Liu

Summary

Affiliation: Taipei Veterans General Hospital
Country: Taiwan

Publications

  1. ncbi request reprint The Alzheimer's Disease Assessment Scale: findings from a low-education population
    Hsiu Chih Liu
    Neurological Institute, Taipei Veterans General Hospital, and National Yang Ming University School of Medicine, Taipei, Taiwan
    Dement Geriatr Cogn Disord 13:21-6. 2002
  2. ncbi request reprint ApoE genotype in relation to AD and cholesterol: a study of 2,326 Chinese adults
    H C Liu
    The Neurological Institute, Veterans General Hospital Taipei and National Yang Ming University School of Medicine, Taiwan
    Neurology 53:962-6. 1999
  3. ncbi request reprint Association analysis of the 5-HT6 receptor polymorphism C267T with depression in patients with Alzheimer's disease
    H C Liu
    Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
    Psychiatry Clin Neurosci 55:427-9. 2001
  4. ncbi request reprint Conversion to dementia from questionable dementia in an ethnic Chinese population
    Hsiu Chih Liu
    Department of Neurology, National Yang Ming University School of Medicine, Taipei
    J Geriatr Psychiatry Neurol 20:76-83. 2007
  5. ncbi request reprint Performance on the cognitive abilities screening instrument at different stages of Alzheimer's disease
    Hsiu Chih Liu
    Neurological Institute, Taipei Veterans General Hospital and National Yang Ming University School of Medicine, Taipei, Taiwan, ROC
    Dement Geriatr Cogn Disord 13:244-8. 2002
  6. ncbi request reprint Cutoff scores of the cognitive abilities screening instrument, Chinese version in screening of dementia
    Ker Neng Lin
    Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    Dement Geriatr Cogn Disord 14:176-82. 2002
  7. ncbi request reprint Brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms in Parkinson's disease and age of onset
    Chen Jee Hong
    Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    Neurosci Lett 353:75-7. 2003
  8. doi request reprint APOE ε4 increases the risk of progression from amnestic mild cognitive impairment to Alzheimer's disease among ethnic Chinese in Taiwan
    Pei ning Wang
    Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan
    J Neurol Neurosurg Psychiatry 82:165-9. 2011
  9. ncbi request reprint Survival of ethnic Chinese with Alzheimer's disease: a 5-year longitudinal study in Taiwan
    Ping Huang Tsai
    Department of Neurology, National Yang Ming University School of Medicine, Taiwan
    J Geriatr Psychiatry Neurol 20:172-7. 2007
  10. ncbi request reprint Study of the association between Alzheimer's disease and angiotensin-converting enzyme gene polymorphism using DNA from lymphocytes
    Chih Ya Cheng
    Department of Psychiatry, Veterans General Hospital Taipei, Taipei, Taiwan, ROC
    Eur Neurol 47:26-9. 2002

Collaborators

Detail Information

Publications44

  1. ncbi request reprint The Alzheimer's Disease Assessment Scale: findings from a low-education population
    Hsiu Chih Liu
    Neurological Institute, Taipei Veterans General Hospital, and National Yang Ming University School of Medicine, Taipei, Taiwan
    Dement Geriatr Cogn Disord 13:21-6. 2002
    ..Its memory items were best for early detection of dementia; its language items were best for monitoring the progression of dementia. This study found that the Chinese ADAS-Cog is a good instrument for use with Chinese AD patients...
  2. ncbi request reprint ApoE genotype in relation to AD and cholesterol: a study of 2,326 Chinese adults
    H C Liu
    The Neurological Institute, Veterans General Hospital Taipei and National Yang Ming University School of Medicine, Taiwan
    Neurology 53:962-6. 1999
    ..To calculate the frequencies of apolipoprotein E (apoE) alleles in a large Chinese community sample and to compare the serum cholesterol levels of epsilon2, epsilon3, and epsilon4 carriers...
  3. ncbi request reprint Association analysis of the 5-HT6 receptor polymorphism C267T with depression in patients with Alzheimer's disease
    H C Liu
    Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
    Psychiatry Clin Neurosci 55:427-9. 2001
    ..The difference in the 5-HT(6) genotype or allele distributions between the AD patients with depressive disorders (n = 25) and those without (n = 120) was not significant...
  4. ncbi request reprint Conversion to dementia from questionable dementia in an ethnic Chinese population
    Hsiu Chih Liu
    Department of Neurology, National Yang Ming University School of Medicine, Taipei
    J Geriatr Psychiatry Neurol 20:76-83. 2007
    ..Cox regression analysis revealed that the Alzheimer's disease converters had lower scores for orientation, short-term memory, and anxiety, and a higher frequency of the apolipoprotein E epsilon4 allele than the nonconverters...
  5. ncbi request reprint Performance on the cognitive abilities screening instrument at different stages of Alzheimer's disease
    Hsiu Chih Liu
    Neurological Institute, Taipei Veterans General Hospital and National Yang Ming University School of Medicine, Taipei, Taiwan, ROC
    Dement Geriatr Cogn Disord 13:244-8. 2002
    ..This study validates the usefulness of the CASI for assessing the severity of dementia. The domain scores differed in their relative usefulness for detecting dementia and for distinguishing in different levels of dementia...
  6. ncbi request reprint Cutoff scores of the cognitive abilities screening instrument, Chinese version in screening of dementia
    Ker Neng Lin
    Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    Dement Geriatr Cogn Disord 14:176-82. 2002
    ..83; specificity = 0.85); Edu = 1-5: 67/68 (sensitivity = 0.83; specificity = 0.91), and Edu >/=6: 79/80 (sensitivity = 0.89; specificity = 0.90)...
  7. ncbi request reprint Brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms in Parkinson's disease and age of onset
    Chen Jee Hong
    Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    Neurosci Lett 353:75-7. 2003
    ..Other BDNF genetic variants, and the association of these variants with PD symptomatology or treatment response, may merit further investigation...
  8. doi request reprint APOE ε4 increases the risk of progression from amnestic mild cognitive impairment to Alzheimer's disease among ethnic Chinese in Taiwan
    Pei ning Wang
    Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan
    J Neurol Neurosurg Psychiatry 82:165-9. 2011
    ..To evaluate the effect of the apolipoprotein E (APOE) ε4 in the progression from mild cognitive impairment (MCI) to Alzheimer's disease (AD) in ethnic Chinese people in Taiwan...
  9. ncbi request reprint Survival of ethnic Chinese with Alzheimer's disease: a 5-year longitudinal study in Taiwan
    Ping Huang Tsai
    Department of Neurology, National Yang Ming University School of Medicine, Taiwan
    J Geriatr Psychiatry Neurol 20:172-7. 2007
    ..As expected, AD shortened life expectancy in these patients. The factors found to correlate with a shorter life span may suggest effective health care strategies for AD patients...
  10. ncbi request reprint Study of the association between Alzheimer's disease and angiotensin-converting enzyme gene polymorphism using DNA from lymphocytes
    Chih Ya Cheng
    Department of Psychiatry, Veterans General Hospital Taipei, Taipei, Taiwan, ROC
    Eur Neurol 47:26-9. 2002
    ..88. Our findings further support previous reports of an association between ACE polymorphism and AD. The implication of the ACE I/D polymorphism in the pathogenesis of AD warrants further exploration...
  11. ncbi request reprint Association analysis for the muscarinic M1 receptor genetic polymorphisms and Alzheimer's disease
    Hsiu Chih Liu
    Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    Dement Geriatr Cogn Disord 19:42-5. 2005
    ..We propose that other genetic variations of CHRM1, relating either to AD or to the therapeutic response for AD, may need further investigation...
  12. ncbi request reprint Cognitive reserve: a SPECT study of 132 Alzheimer's disease patients with an education range of 0-19 years
    Yi Chu Liao
    Department of Neurology, National Yang Ming University School of Medicine and Department of Nuclear Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Dement Geriatr Cogn Disord 20:8-14. 2005
    ..They also suggest that the main effect of more education is a more facile use of alternative brain circuits instead of locally increased synaptic connections...
  13. ncbi request reprint Lack of association between the interleukin-1alpha gene C(-889)T polymorphism and Alzheimer's disease in a Chinese population
    Shih Jen Tsai
    Department of Psychiatry, Veterans General Hospital Taipei, Taipei, Taiwan, ROC
    Neurosci Lett 343:93-6. 2003
    ..Further studies of the associations between other IL-1A genetic polymorphisms and AD are needed to fully elaborate the involvement of this gene in AD...
  14. ncbi request reprint Smoking and cognitive performance in the community elderly: a longitudinal study
    Wei Ta Chen
    Neuralogical Institute, Taipei Veterans General Hospital, Taipei, Taiwan
    J Geriatr Psychiatry Neurol 16:18-22. 2003
    ..The lifetime cigarette exposure was not predictive of the cognitive status. At a 3-year follow-up, neither the smoking status nor the lifetime cigarette exposure predicted the declination of cognition...
  15. ncbi request reprint Association analysis for the genetic variants of the NMDA receptor subunit 2b and Alzheimer's disease
    Shih Jen Tsai
    School of Medicine, National Yang Ming University, Taipei, Taiwan, ROC
    Dement Geriatr Cogn Disord 13:91-4. 2002
    ..We propose that other genetic variations of the NMDA subunits, relating either to AD or to the therapeutic response for NMDA partial agonists, may need further investigation...
  16. ncbi request reprint Association analysis of brain-derived neurotrophic factor Val66Met polymorphisms with Alzheimer's disease and age of onset
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    Neuropsychobiology 49:10-2. 2004
    ..Further studies with genetic variations in BDNF relating either to AD-associated depression or to the AD treatment response are suggested...
  17. ncbi request reprint Selective hypoperfusion of anterior cingulate gyrus in depressed AD patients: a brain SPECT finding by statistical parametric mapping
    Yi Chu Liao
    Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
    Dement Geriatr Cogn Disord 16:238-44. 2003
    ..The right anterior cingulate gyrus demonstrated a most significant reduction in perfusion. These locations are akin to the imaging findings in patients with primary depression, indicating a specific pathogenesis for depression in AD...
  18. ncbi request reprint Statistical parametric mapping of brain SPECT perfusion abnormalities in patients with Alzheimer's disease
    Yi Chung Lee
    Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
    Eur Neurol 49:142-5. 2003
    ..In moderate AD patients, significant cerebral hypoperfusion was located in bilateral posterior parietotemporal cortices, contiguous anterior occipital lobes, posterior cingulate gyri and, to a lesser extent, in frontal areas...
  19. ncbi request reprint The three-item clock-drawing test: a simplified screening test for Alzheimer's disease
    Ker Neng Lin
    Neurological Institute, Taipei Veterans General Hospital and Department of Neurology, National Yang Ming University School of Medicine, Taipei, Taiwan
    Eur Neurol 49:53-8. 2003
    ..7%; CDT-C: 51.4%) and specificity (CDT-D: 74.5%; CDT-C: 74.1%). The simplified 3-item CDT scoring system, with a cutoff score of 2/3, has a sensitivity of 72.9% and a specificity of 65.6%; it can be used as a quick test for AD screening...
  20. ncbi request reprint Association study for Parkinson's disease and a dopamine transporter gene polymorphism (1215A/G)
    Chien Nan Lin
    Provisional Chia Nan Psychiatric Center, Tainan, Taiwan, ROC
    Eur Neurol 48:207-9. 2002
    ..Other DAT genetic variants, and the association of these variants with PD symptomatology or treatment response, may merit further investigation...
  21. ncbi request reprint Correlation between platelet amyloid precursor protein isoform ratio and cognition in Alzheimer's disease
    Hsiu Chih Liu
    Department of Neurology, National Yang Ming University School of Medicine, Taipei, Taiwan
    J Alzheimers Dis 11:77-84. 2007
    ..These findings indicate that AbetaPP isoform ratio correlates with cognition, and reduction in this ratio may be a marker for cognitive decline in AD patients...
  22. ncbi request reprint Association analysis of adenosine A2a receptor 1976T>C polymorphisms and Alzheimer's disease
    Hsiu Chih Liu
    Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    Eur Neurol 53:99-100. 2005
  23. ncbi request reprint Evaluating the uses of the total score and the domain scores in the Cognitive Abilities Screening Instrument, Chinese version (CASI C-2.0): results of confirmatory factor analysis
    Rung Ching Tsai
    Department of Mathematics, National Taiwan Normal University, Taipei, Taiwan
    Int Psychogeriatr 19:1051-63. 2007
    ..This study aimed to evaluate the justification of the uses of the all-domain-total-score as an overall cognitive measure and the domain scores as measures of designated individual cognitive ability...
  24. ncbi request reprint Improving the screening power of the cognitive abilities screening instrument, Chinese version
    Rung Ching Tsai
    Department of Mathematics, National Taiwan Normal University, Taipei, Taiwan, ROC
    Dement Geriatr Cogn Disord 18:314-20. 2004
    ..With the weighted scoring system of the 9 domains for patients from the targeted population, we hope to make the CASI a clinically more powerful tool in screening dementia...
  25. ncbi request reprint The MCI study in Taiwan
    Pei ning Wang
    Neurological Institutes, Taipei Veterans General Hospital, Department of Neurology, National Yang Ming University School of Medicine, Fu Jen Catholic University, Taipei, Taiwan
    Acta Neurol Taiwan 15:66-8. 2006
    ..With rapidly expanding research on dementia and MCI worldwide, we are looking forward to seeing the integration in neurobiology, neuroimaging, and neurobehavior fields to establish a multidisciplinary approach to MCI and dementia...
  26. ncbi request reprint The brain-derived neurotrophic factor gene as a possible susceptibility candidate for Alzheimer's disease in a chinese population
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    Dement Geriatr Cogn Disord 21:139-43. 2006
    ..002). These results suggest that BDNF genetic variation may possibly affect the risk for AD, particularly in subjects who are negative for APOE4...
  27. ncbi request reprint [Cognitive Abilities Screening Instrument, Chinese Version 2.0 (CASI C-2.0): administration and clinical application]
    Ker Neng Lin
    Department of Neurology, Taipei Veterans General Hospital, Taiwan
    Acta Neurol Taiwan 21:180-9. 2012
    ..In clinical practice, the cut-off scores in differentiating between dementia and normal are suggested to be: 49/50 for Education year = 0; 67/68 for Education years = 1-5; and 79/80 for Education years more than 6...
  28. ncbi request reprint Polymorphisms of estrogen-metabolizing genes and risk of hepatocellular carcinoma in Taiwan females
    Pen Hui Yin
    Institute of Pharmacology, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Cancer Lett 212:195-201. 2004
    ..63 (1.50, 106.37), and the OR for three putative high-risk genotypes was 16.67 (1.82, 152.77). These findings strongly suggest that estrogen play a critical role in female hepatocarcinogenesis...
  29. ncbi request reprint Midlife risk factors for subtypes of dementia: a nested case-control study in Taiwan
    Chun Ju Chiang
    Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
    Am J Geriatr Psychiatry 15:762-71. 2007
    ..To identify the midlife risk factors for subtypes of dementia newly developed later in life...
  30. ncbi request reprint Longitudinal cerebral perfusion decrease in mild alzheimer's disease revealed by SPECT with statistical parametric mapping method
    Yi Chung Lee
    The Neurological Institute, Taipei Veterans General Hospital, Section of Neurology, 201 Section 2 Shih Pai Road, Shih Pai, Taipei 11217, Taiwan
    Eur Neurol 52:42-9. 2004
    ..The visual construction sub-score was significantly correlated with perfusion of the right superior and medial frontal gyri...
  31. ncbi request reprint Accelerated hippocampal atrophy rates in stable and progressive amnestic mild cognitive impairment
    Pei ning Wang
    Department of Neurology, National Yang Ming University School of Medicine, Taipei, Taiwan
    Psychiatry Res 171:221-31. 2009
    ..Therefore, accelerated hippocampal atrophy rates may be an early and important presentation in MCI subjects...
  32. ncbi request reprint Weight loss, nutritional status and physical activity in patients with Alzheimer's disease. A controlled study
    Pei ning Wang
    Neurological Institute, Taipei Veterans General Hospital and Dept of Neurology, National Yang Ming University School of Medicine, Taipei, Taiwan
    J Neurol 251:314-20. 2004
    ..We suggest that the pathophysiological process in AD gives rise to the changes of appetite and metabolic state in AD patients, and that these changes contribute to the weight loss...
  33. ncbi request reprint Family members favor disclosing the diagnosis of Alzheimer's disease
    Ker Neng Lin
    Department of Neurology, National Yang Ming University School of Medicine and The Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
    Int Psychogeriatr 17:679-88. 2005
    ..In this study, we surveyed the family members of neurological patients in Taiwan for the purpose of assessing their attitudes towards the disclosure of AD diagnosis...
  34. ncbi request reprint Wernicke's encephalopathy in a patient with multiple symmetrical lipomatosis and the A8344G mutation of mitochondrial DNA
    Yi Chung Lee
    Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
    Eur Neurol 47:126-8. 2002
  35. pmc Amyloid-beta (Aβ) D7H mutation increases oligomeric Aβ42 and alters properties of Aβ-zinc/copper assemblies
    Wei Ting Chen
    Institute of Brain Science, National Yang Ming University, Taipei, Taiwan
    PLoS ONE 7:e35807. 2012
    ....
  36. ncbi request reprint Isolated oculomotor nerve palsy due to head injury
    Yo Tsen Liu
    The Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    J Chin Med Assoc 67:149-51. 2004
    ..Further case collections with modern imaging studies are needed to clarify the mechanisms and clinical characteristics associated with this phenomenon...
  37. ncbi request reprint Getting lost: directed attention and executive functions in early Alzheimer's disease patients
    Yi Chen Chiu
    Chang Gung University, Department and Graduate Institute of Nursing, Taoyuan, Taiwan
    Dement Geriatr Cogn Disord 17:174-80. 2004
    ....
  38. ncbi request reprint Lack of association between the apolipoprotein E genotype and depression in Alzheimer's disease
    Chia Yih Liu
    Department of Psychiatry, Chang Gung University School of Medicine and Chang Gung Memorial Hospital, Taoyuan, Taiwan
    J Geriatr Psychiatry Neurol 15:20-3. 2002
    ..The HDRS scores were not different in patients with AD with the epsilon4 or epsilon2 allele or in those patients without them. Our study did not find an association between depression and the apo E epsilon4 or epsilon2 allele in AD...
  39. ncbi request reprint No association between the neuronal nitric oxide synthase gene polymorphism and Alzheimer Disease
    Ying Jay Liou
    Section of Psychiatry, Yu Li Veterans Hospital, Hualien, Taiwan, Republic of China
    Am J Med Genet 114:687-8. 2002
    ..No association was demonstrated for AD and this particular nNOS polymorphism...
  40. ncbi request reprint Conceptualization and measurement of getting lost behavior in persons with early dementia
    Yi Chen Chiu
    Chung Gang University, School of Nursing, Taiwan
    Int J Geriatr Psychiatry 20:760-8. 2005
    ..The ESQD-P is a measure for the phenomenon of 'getting lost behavior' (GLB) reported by early Alzheimer's disease sufferers, based on the concept of spatial problem-solving...
  41. ncbi request reprint Behavioral and psychological symptoms in Taiwanese patients with Alzheimer's disease
    Chia Yih Liu
    Department of Psychiatry, Chang Gung Memorial Hospital and Institute of Clinical Behavioral Sciences, Chang Gung University, Taiwan
    Int Psychogeriatr 19:605-13. 2007
    ..To investigate the prevalence of and risk factors for behavioral and psychological symptoms in Taiwanese Alzheimer's disease (AD) patients...
  42. ncbi request reprint Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: two novel mutations in the NOTCH3 gene in Chinese
    Yi Chung Lee
    Section of Neurology, Taichung Veterans General Hospital, Taichung, Taiwan
    J Neurol Sci 246:111-5. 2006
    ..So far, there has been only limited information about CADASIL in Chinese population...
  43. ncbi request reprint Multiple sclerosis: an emerging diagnosis in Taiwan?
    Hsiu Chih Liu
    J Chin Med Assoc 67:494-5. 2004
  44. ncbi request reprint Magnetic resonance imaging segmentation techniques using batch-type learning vector quantization algorithms
    Miin Shen Yang
    Department of Applied Mathematics, Chung Yuan Christian University, Chung Li 32023, Taiwan
    Magn Reson Imaging 25:265-77. 2007
    ..Specifically, the proposed fuzzy-soft LVQ algorithm works well in segmenting AD MRI data set to accurately measure the hippocampus volume in AD MR images...