Chien Huang Lin

Summary

Affiliation: Taipei Medical University
Country: Taiwan

Publications

  1. pmc NF-κB repressing factor downregulates basal expression and mycobacterium tuberculosis induced IP-10 and IL-8 synthesis via interference with NF-κB in monocytes
    Kuo Hsiung Huang
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, 250 Wu Hsing Street, Taipei 110, Taiwan
    J Biomed Sci 21:71. 2014
  2. ncbi request reprint Lipoteichoic acid-induced cyclooxygenase-2 expression requires activations of p44/42 and p38 mitogen-activated protein kinase signal pathways
    Chien Huang Lin
    Graduate Institute of Biomedical Technology, Taipei Medical University, Taipei, Taiwan, ROC
    Eur J Pharmacol 450:1-9. 2002
  3. pmc Induction of cyclooxygenase-2 protein by lipoteichoic acid from Staphylococcus aureus in human pulmonary epithelial cells: involvement of a nuclear factor-kappa B-dependent pathway
    C H Lin
    Graduate Institute of Biomedical Technology, Taipei Medical University, Taipei, Taiwan
    Br J Pharmacol 134:543-52. 2001
  4. ncbi request reprint YC-1-induced cyclooxygenase-2 expression is mediated by cGMP-dependent activations of Ras, phosphoinositide-3-OH-kinase, Akt, and nuclear factor-kappaB in human pulmonary epithelial cells
    Ming Shyan Chang
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, 250 Wu Hsing Street, Taipei 110, Taiwan
    Mol Pharmacol 66:561-71. 2004
  5. ncbi request reprint Mechanisms involved in the antiplatelet activity of ketamine in human platelets
    Yi Chang
    Department of Anesthesiology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan, ROC
    J Biomed Sci 11:764-72. 2004
  6. pmc YC-1 increases cyclo-oxygenase-2 expression through protein kinase G- and p44/42 mitogen-activated protein kinase-dependent pathways in A549 cells
    Ming Shyan Chang
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan
    Br J Pharmacol 136:558-67. 2002
  7. ncbi request reprint Bradykinin B2 receptor mediates NF-kappaB activation and cyclooxygenase-2 expression via the Ras/Raf-1/ERK pathway in human airway epithelial cells
    Bing Chang Chen
    School of Respiratory Therapy, Taipei Medical University, Taiwan
    J Immunol 173:5219-28. 2004
  8. ncbi request reprint Mechanisms of antiplatelet and antithrombotic activity of midazolam in in vitro and in vivo studies
    George Hsiao
    Graduate Institute of Pharmacology, Taipei Medical University, Taipei, Taiwan
    Eur J Pharmacol 487:159-66. 2004
  9. pmc Lipoteichoic acid induces nuclear factor-kappaB activation and nitric oxide synthase expression via phosphatidylinositol 3-kinase, Akt, and p38 MAPK in RAW 264.7 macrophages
    Shang Jyh Kao
    Department of Chest Medicine, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Immunology 115:366-74. 2005
  10. ncbi request reprint Role of protein kinase C in BSA-AGE-mediated inducible nitric oxide synthase expression in RAW 264.7 macrophages
    Chih Hsiung Wu
    School of Medicine, Taipei Medical University, Taipei, Taiwan, ROC
    Biochem Pharmacol 66:203-12. 2003

Collaborators

Detail Information

Publications94

  1. pmc NF-κB repressing factor downregulates basal expression and mycobacterium tuberculosis induced IP-10 and IL-8 synthesis via interference with NF-κB in monocytes
    Kuo Hsiung Huang
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, 250 Wu Hsing Street, Taipei 110, Taiwan
    J Biomed Sci 21:71. 2014
    ..However, the mechanism underlying the repressive effect of NKRF is not fully understood...
  2. ncbi request reprint Lipoteichoic acid-induced cyclooxygenase-2 expression requires activations of p44/42 and p38 mitogen-activated protein kinase signal pathways
    Chien Huang Lin
    Graduate Institute of Biomedical Technology, Taipei Medical University, Taipei, Taiwan, ROC
    Eur J Pharmacol 450:1-9. 2002
    ..Both events required activation of upstream tyrosine kinase and PKC...
  3. pmc Induction of cyclooxygenase-2 protein by lipoteichoic acid from Staphylococcus aureus in human pulmonary epithelial cells: involvement of a nuclear factor-kappa B-dependent pathway
    C H Lin
    Graduate Institute of Biomedical Technology, Taipei Medical University, Taipei, Taiwan
    Br J Pharmacol 134:543-52. 2001
    ....
  4. ncbi request reprint YC-1-induced cyclooxygenase-2 expression is mediated by cGMP-dependent activations of Ras, phosphoinositide-3-OH-kinase, Akt, and nuclear factor-kappaB in human pulmonary epithelial cells
    Ming Shyan Chang
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, 250 Wu Hsing Street, Taipei 110, Taiwan
    Mol Pharmacol 66:561-71. 2004
    ....
  5. ncbi request reprint Mechanisms involved in the antiplatelet activity of ketamine in human platelets
    Yi Chang
    Department of Anesthesiology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan, ROC
    J Biomed Sci 11:764-72. 2004
    ....
  6. pmc YC-1 increases cyclo-oxygenase-2 expression through protein kinase G- and p44/42 mitogen-activated protein kinase-dependent pathways in A549 cells
    Ming Shyan Chang
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan
    Br J Pharmacol 136:558-67. 2002
    ....
  7. ncbi request reprint Bradykinin B2 receptor mediates NF-kappaB activation and cyclooxygenase-2 expression via the Ras/Raf-1/ERK pathway in human airway epithelial cells
    Bing Chang Chen
    School of Respiratory Therapy, Taipei Medical University, Taiwan
    J Immunol 173:5219-28. 2004
    ....
  8. ncbi request reprint Mechanisms of antiplatelet and antithrombotic activity of midazolam in in vitro and in vivo studies
    George Hsiao
    Graduate Institute of Pharmacology, Taipei Medical University, Taipei, Taiwan
    Eur J Pharmacol 487:159-66. 2004
    ..These lead to lower intracellular Ca(+2) mobilization and phosphorylation of P47...
  9. pmc Lipoteichoic acid induces nuclear factor-kappaB activation and nitric oxide synthase expression via phosphatidylinositol 3-kinase, Akt, and p38 MAPK in RAW 264.7 macrophages
    Shang Jyh Kao
    Department of Chest Medicine, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Immunology 115:366-74. 2005
    ..7 macrophages...
  10. ncbi request reprint Role of protein kinase C in BSA-AGE-mediated inducible nitric oxide synthase expression in RAW 264.7 macrophages
    Chih Hsiung Wu
    School of Medicine, Taipei Medical University, Taipei, Taiwan, ROC
    Biochem Pharmacol 66:203-12. 2003
    ..Taken together, these data suggest that BSA-AGEs might activate PKC and subsequently induce iNOS expression and NO release...
  11. ncbi request reprint Induction of nitric oxide synthase in RAW 264.7 macrophages by lipoteichoic acid from Staphylococcus aureus: involvement of protein kinase C- and nuclear factor-kB-dependent mechanisms
    Chen Tzu Kuo
    Graduate Institute of Biomedical Technology, Taipei Medical University, Taipei, Taiwan
    J Biomed Sci 10:136-45. 2003
    ..These results suggest that LTA might activate PC-PLC and PI-PLC to induce PKC activation, which in turn initiates NF-kappaB activation, and finally induces iNOS expression and NO release in RAW 264.7 macrophages...
  12. ncbi request reprint Peptidoglycan induces nuclear factor-kappaB activation and cyclooxygenase-2 expression via Ras, Raf-1, and ERK in RAW 264.7 macrophages
    Bing Chang Chen
    School of Respiratory Therapy, Taipei Medical University, 250 Wu Hsing Street, Taipei 110, Taiwan
    J Biol Chem 279:20889-97. 2004
    ..Our data demonstrate for the first time that PGN activates the Ras/Raf-1/ERK pathway, which in turn initiates IKKalpha/beta and NF-kappaB activation, and ultimately induces COX-2 expression in RAW 264.7 macrophages...
  13. ncbi request reprint Peptidoglycan-induced IL-6 production in RAW 264.7 macrophages is mediated by cyclooxygenase-2, PGE2/PGE4 receptors, protein kinase A, I kappa B kinase, and NF-kappa B
    Bing Chang Chen
    School of Respiratory Therapy, Graduate Institute of Biomedical Technology, College of Medicine, Taipei Medical University, 250 Wu Hsing Street, Taipei 110, Taiwan
    J Immunol 177:681-93. 2006
    ..However, PGN-induced NO release is not involved in the signaling pathway of PGN-induced IL-6 production...
  14. ncbi request reprint Magnolol suppresses proliferation of cultured human colon and liver cancer cells by inhibiting DNA synthesis and activating apoptosis
    Shyr Yi Lin
    Department of Physiology, Graduate Institute of Medical Sciences, Taipei Medical University, Taipei 110, Taiwan
    J Cell Biochem 84:532-44. 2002
    ..These findings demonstrate for the first time that magnolol can inhibit the proliferation of tumor cells in vitro and in vivo...
  15. ncbi request reprint Phorbol 12-myristate 13-acetate upregulates cyclooxygenase-2 expression in human pulmonary epithelial cells via Ras, Raf-1, ERK, and NF-kappaB, but not p38 MAPK, pathways
    Ming Shyan Chang
    Graduate Institute of Biomedical Technology, Taipei Medical University, Taipei, Taiwan
    Cell Signal 17:299-310. 2005
    ..Taken together, these results indicate that PMA might activate PKC to elicit activation of the Ras/Raf-1/ERK1/2 pathway, which in turn initiates NF-kappaB activation, and finally induces COX-2 expression and PGE2 release in A549 cells...
  16. doi request reprint Thrombin-induced CCN2 expression in human lung fibroblasts requires the c-Src/JAK2/STAT3 pathway
    Kua Jen Bai
    College of Medicine, Taipei Medical University, 250 Wu Hsing St, Taipei, Taiwan
    J Leukoc Biol 93:101-12. 2013
    ..Taken together, these results indicate that thrombin might activate c-Src to induce JAK2 activation, which in turn, causes STAT3 activation, and finally induces CCN2 expression in human lung fibroblasts...
  17. ncbi request reprint Involvement of the antiplatelet activity of magnesium sulfate in suppression of protein kinase C and the Na+/H+ exchanger
    George Hsiao
    Graduate Institute of Pharmacology, Taipei Medical University, No 250 Wu Hsing Street, Taipei 110, Taiwan
    J Biomed Sci 11:19-26. 2004
    ..2) On the other hand, magnesium sulfate inhibits the Na+/H+ exchanger, leading to reduced intracellular Ca+2 mobilization, and ultimately to inhibition of platelet aggregation and the ATP-release reaction...
  18. ncbi request reprint In vitro and in vivo studies of the anticancer action of terbinafine in human cancer cell lines: G0/G1 p53-associated cell cycle arrest
    Wen Sen Lee
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan
    Int J Cancer 106:125-37. 2003
    ..These findings demonstrate for the first time that TB can inhibit the proliferation of tumor cells in vitro and in vivo...
  19. ncbi request reprint Inhibitory mechanisms of YC-1 and PMC in the induction of iNOS expression by lipoteichoic acid in RAW 264.7 macrophages
    George Hsiao
    Graduate Institute of Pharmacology, Taipei Medical University, 250 Wu Shing Street, Taipei 110, Taiwan, ROC
    Biochem Pharmacol 67:1411-9. 2004
    ..YC-1 may be mediated by increasing cyclic GMP, followed by, at least partly, inhibition of JNK/SAPK and NF-kappaB activations, thereby leading to inhibition of iNOS expression...
  20. ncbi request reprint Involvement of p38 mitogen-activated protein kinase in PLL-AGE-induced cyclooxgenase-2 expression
    Chien Huang Lin
    Graduate Institute of Biomedical Technology and School of Medical Technology, 250, Wu Hsing Street, 110, Taipei, Taiwan
    Eur J Pharmacol 438:143-52. 2002
    ..Taken together, our results suggest that activation of protein tyrosine kinase and p38 MAPK is involved in AGE-induced cyclooxygenase-2 expression in RAW 264.7 macrophages...
  21. doi request reprint Denbinobin induces human glioblastoma multiforme cell apoptosis through the IKKα-Akt-FKHR signaling cascade
    Hsing Yu Weng
    Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, No 250, Wu Hsing Street, Taipei 11031, Taiwan
    Eur J Pharmacol 698:103-9. 2013
    ..These results suggest that IKKα inactivation, followed by Akt and FKHR dephosphorylation and caspase-3 activation, contributes to denbinobin-induced GBM cell apoptosis...
  22. pmc Thrombin induces NF-kappaB activation and IL-8/CXCL8 expression in lung epithelial cells by a Rac1-dependent PI3K/Akt pathway
    Chien Huang Lin
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
    J Biol Chem 286:10483-94. 2011
    ....
  23. ncbi request reprint Neutrophil elastase induces IL-8 synthesis by lung epithelial cells via the mitogen-activated protein kinase pathway
    Hao Cheng Chen
    Department of Thoracic Medicine II, Chang Gung Memorial Hospital, 199 Tun Hwa N Road, Taipei 10507, Taiwan, ROC
    J Biomed Sci 11:49-58. 2004
    ..Tyrosine kinase and PKC are implicated in neutrophil elastase activation of the MAPK pathway...
  24. ncbi request reprint Lipoteichoic acid-induced nitric oxide synthase expression in RAW 264.7 macrophages is mediated by cyclooxygenase-2, prostaglandin E2, protein kinase A, p38 MAPK, and nuclear factor-kappaB pathways
    Yau Chong Chang
    Department of Cardiac Surgery, Taipei Medical University, Wang Fang Hospital, Taipei, Taiwan Graduate Institute of Injury Prevention, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan
    Cell Signal 18:1235-43. 2006
    ..These results suggest that LTA-induced iNOS expression and NO release involve COX-2-generated PGE2 production, and AC, PKA, p38 MAPK, and NF-kappaB activation in RAW 264.7 macrophages...
  25. ncbi request reprint c-Src mediates thrombin-induced NF-kappaB activation and IL-8/CXCL8 expression in lung epithelial cells
    Chien Huang Lin
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taiwan
    J Immunol 177:3427-38. 2006
    ....
  26. ncbi request reprint Morphine-potentiated platelet aggregation in in vitro and platelet plug formation in in vivo experiments
    George Hsiao
    Department of Pharmacology, Taipei Medical University, No 250 Wu Hsing Street, Taipei 110, Taiwan
    J Biomed Sci 10:292-301. 2003
    ..This leads to increased intracellular Ca(2+) mobilization, and finally potentiation of platelet aggregation and of the ATP release reaction...
  27. doi request reprint Connective tissue growth factor induces collagen I expression in human lung fibroblasts through the Rac1/MLK3/JNK/AP-1 pathway
    Chien Huang Lin
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
    Biochim Biophys Acta 1833:2823-33. 2013
    ....
  28. ncbi request reprint C-phycocyanin, a very potent and novel platelet aggregation inhibitor from Spirulina platensis
    George Hsiao
    Graduate Institute of Pharmacology, and Graduate Institute of Medical Sciences, Taipei Medical University, Taipei 110, Taiwan
    J Agric Food Chem 53:7734-40. 2005
    ..These results strongly indicate that C-PC appears to represent a novel and potential antiplatelet agent for treatment of arterial thromboembolism...
  29. doi request reprint Denbinobin induces apoptosis in human lung adenocarcinoma cells via Akt inactivation, Bad activation, and mitochondrial dysfunction
    Chen Tzu Kuo
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
    Toxicol Lett 177:48-58. 2008
    ..These results suggest that Akt inactivation, followed by Bad activation, mitochondrial dysfunction, caspase 3 activation, and AIF release, contributes to denbinobin-induced cell apoptosis...
  30. doi request reprint Involvement of phosphatidylcholine-phospholipase C and protein kinase C in peptidoglycan-induced nuclear factor-kappaB activation and cyclooxygenase-2 expression in RAW 264.7 macrophages
    Jam Inn Tzeng
    Department of Anesthesiology, Chi Mei Medical Center, Tainan, Taiwan, ROC
    Pharmacol Res 61:162-6. 2010
    ..Our data demonstrate that PGN activates PC-PLC which induces PKC activation; this in turn initiates NF-kappaB activation, and ultimately induces COX-2 expression in RAW 264.7 macrophages...
  31. doi request reprint Thrombin induces inducible nitric oxide synthase expression via the MAPK, MSK1, and NF-κB signaling pathways in alveolar macrophages
    Chen Chun Lin
    Department of Chest Medicine, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Eur J Pharmacol 672:180-7. 2011
    ..Taken together, these results suggest that the signaling pathways of MAPK, MSK1, and NF-κB play important roles in thrombin-induced iNOS expression in alveolar macrophages...
  32. pmc Impact of VEGF-C gene polymorphisms and environmental factors on oral cancer susceptibility in Taiwan
    Ming Hsien Chien
    Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
    PLoS ONE 8:e60283. 2013
    ..This study was designed to examine associations of five VEGF-C gene polymorphisms with the susceptibility to and clinicopathological characteristics of oral squamous cell carcinoma...
  33. ncbi request reprint Effects of sphondin, isolated from Heracleum laciniatum, on IL-1beta-induced cyclooxygenase-2 expression in human pulmonary epithelial cells
    Ling Ling Yang
    Graduate Institute of Pharmacognosy Science, Taipei Medical University, Taipei, Taiwan
    Life Sci 72:199-213. 2002
    ..We conclude that sphondin may have the therapeutic potential as an anti-inflammatory drug on airway inflammation...
  34. ncbi request reprint Low concentration of oxidized low density lipoprotein suppresses platelet reactivity in vitro: an intracellular study
    Duen Suey Chou
    Graduate Institutes of Medical Sciences and Pharmacology, Taipei Medical University, Taipei 110, Taiwan
    Lipids 39:433-40. 2004
    ..This study provides new insights concerning the effect of oxLDL in platelet aggregation...
  35. doi request reprint Apoptosis signal-regulating kinase 1 in peptidoglycan-induced COX-2 expression in macrophages
    Ming Jen Hsu
    Graduate Institute of Medical Sciences, Department of Pharmacology, College of Medicine, Taipei Medical University, 250 Wu Hsing Street, Taipei 110, Taiwan
    J Leukoc Biol 87:1069-82. 2010
    ..7 macrophages. Our data demonstrate that PGN might activate the TLR2-mediated PP2A-ASK1-JNK-AP-1-C/EBPbeta cascade and subsequent COX-2 expression in RAW 264.7 macrophages...
  36. doi request reprint Trichostatin A and sirtinol suppressed survivin expression through AMPK and p38MAPK in HT29 colon cancer cells
    Ya Fen Hsu
    Division of General Surgery, Department of Surgery, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Biochim Biophys Acta 1820:104-15. 2012
    ..HDAC inhibition induces growth arrest and cell death in various transformed cell; however, the mechanisms by which this reduces cell viability in colorectal cancer cells remain unexplained...
  37. doi request reprint Ghrelin induces colon cancer cell proliferation through the GHS-R, Ras, PI3K, Akt, and mTOR signaling pathways
    Gi Shih Lien
    Division of Gastroenterology, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei 110, Taiwan
    Eur J Pharmacol 776:124-31. 2016
    ..These results indicate that the Ras/PI3K/Akt/mTOR cascade plays a critical role in ghrelin-induced colon cancer cell proliferation. ..
  38. doi request reprint Thrombin-induced NF-κB activation and IL-8/CXCL8 release is mediated by c-Src-dependent Shc, Raf-1, and ERK pathways in lung epithelial cells
    Chien Huang Lin
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
    Cell Signal 25:1166-75. 2013
    ....
  39. ncbi request reprint Apoptotic neutrophils undergoing secondary necrosis induce human lung epithelial cell detachment
    Chien Ying Liu
    Department of Thoracic Medicine II, Chang Gung Memorial Hospital, Chang Gung University, 199 Tunhwa N Road, Taipei 105, Taiwan, ROC
    J Biomed Sci 10:746-56. 2003
    ..Furthermore, the rapidity of the transition emphasizes the importance of the prompt clearance of apoptotic neutrophils before they progress to secondary necrosis at the site of lung inflammation...
  40. doi request reprint Thrombin-induced connective tissue growth factor expression in human lung fibroblasts requires the ASK1/JNK/AP-1 pathway
    Chung Chi Yu
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
    J Immunol 182:7916-27. 2009
    ....
  41. doi request reprint Interleukin-23 receptor polymorphism as a risk factor for oral cancer susceptibility
    Ming Hsien Chien
    Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
    Head Neck 34:551-6. 2012
    ..The purpose of this study was to evaluate the influence of genetic polymorphisms of interleukin (IL)-23 and the IL-23 receptor (IL-23R) on the susceptibility to oral cancer...
  42. doi request reprint Mitochondrial mechanisms in amyloid beta peptide-induced cerebrovascular degeneration
    Ming Jen Hsu
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
    Biochim Biophys Acta 1800:290-6. 2010
    ..Understanding these death signaling processes will aid in the development of more effective strategies to slow down age-dependent cerebrovascular degeneration caused by progressive cerebrovascular Abeta deposition...
  43. doi request reprint The endothelin A receptor mediates fibrocyte differentiation in chronic obstructive asthma. The involvement of connective tissue growth factor
    Chih Ming Weng
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
    Am J Respir Crit Care Med 188:298-308. 2013
    ..Endothelin-1 (ET-1) induces matrix-associated gene expression through the ETA receptor (ETAR) and promotes fibroblast differentiation. However, the mechanism of fibrocyte differentiation remains unclear...
  44. ncbi request reprint Inhibitory activity of kinetin on free radical formation of activated platelets in vitro and on thrombus formation in vivo
    George Hsiao
    Department of Pharmacology, Taipei Medical University, Taipei, Taiwan, ROC
    Eur J Pharmacol 465:281-7. 2003
    ..Treatment with kinetin may lower the risk of thromboembolic-related disorders. Therefore, kinetin may be a potential therapeutic agent for arterial thrombosis, but its toxicity must be further assessed...
  45. ncbi request reprint Advanced glycosylation end products induce NF-kappaB dependent iNOS expression in RAW 264.7 cells
    Chih Hsiung Wu
    School of Medicine, Taipei Medical University, Taipei, Taiwan, ROC
    Mol Cell Endocrinol 194:9-17. 2002
    ..These results suggest that AGEs may activate NF-kappaB via an upstream signaling cascade composed of tyrosine kinase, PI 3-K, PKC, and p38 MAPK, resulting in the induction of iNOS expression in RAW 264.7 macrophages...
  46. ncbi request reprint Mechanisms involved in agonist-induced hyperaggregability of platelets from normal pregnancy
    Joen Rong Sheu
    Graduate Institute of Medical Sciences, Department of Pharmacology, Taipei Medical University, Taipei, Taiwan, ROC
    J Biomed Sci 9:17-25. 2002
    ....
  47. pmc Impacts of CA9 gene polymorphisms and environmental factors on oral-cancer susceptibility and clinicopathologic characteristics in Taiwan
    Ming Hsien Chien
    Wan Fan Hospital, Taipei Medical University, Taipei, Taiwan
    PLoS ONE 7:e51051. 2012
    ....
  48. doi request reprint MAPK phosphatase-1 contributes to trichostatin A inhibition of cyclooxygenase-2 expression in human umbilical vascular endothelial cells exposed to lipopolysaccharide
    Ya Fen Hsu
    Department of Surgery, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Biochim Biophys Acta 1810:1160-9. 2011
    ..In the present study, we explored the actions of trichostatin A (TSA), a potent HDAC inhibitor, on lipopolysaccharide (LPS)-induced cyclooxygenase (COX)-2 expression in human umbilical vascular endothelial cells (HUVECs)...
  49. doi request reprint Endothelin-1 induces connective tissue growth factor expression in human lung fibroblasts by ETAR-dependent JNK/AP-1 pathway
    Chih Ming Weng
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan
    Biochem Pharmacol 88:402-11. 2014
    ..These results suggest that ET-1 stimulates expressions of CTGF and α-SMA through ETAR/JNK/AP-1 signaling pathway, and CTGF is required for ET-1-induced α-SMA expression in human lung fibroblasts...
  50. doi request reprint Thrombin-induced CCAAT/enhancer-binding protein β activation and IL-8/CXCL8 expression via MEKK1, ERK, and p90 ribosomal S6 kinase 1 in lung epithelial cells
    Chien Huang Lin
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
    J Immunol 192:338-48. 2014
    ....
  51. ncbi request reprint Antioxidative and hepatoprotective effects of Antrodia camphorata extract
    George Hsiao
    Department of Pharmacology and Graduate Institute of Medical Sciences, Taipei Medical University, 250 Wu Hsing Street, Taipei 110, Taiwan
    J Agric Food Chem 51:3302-8. 2003
    ..These results suggest that A. camphorata extract exerts effective protection against chronic chemical-induced hepatic injury in vivo, by mediating antioxidative and free radical scavenging activities...
  52. ncbi request reprint YC-1 inhibits proliferation of human vascular endothelial cells through a cyclic GMP-independent pathway
    Hun Kung Hsu
    Graduate Institute of Medical Sciences, Taipei Medical University, 250 Wu Hsing Street, Taipei 110, Taiwan, ROC
    Biochem Pharmacol 66:263-71. 2003
    ..This YC-1-induced antiproliferation effect in HUVEC is via a cyclic GMP-independent pathway...
  53. ncbi request reprint Antitumor effects of miconazole on human colon carcinoma xenografts in nude mice through induction of apoptosis and G0/G1 cell cycle arrest
    Chih Hsiung Wu
    School of Medicine, Taipei Medical University, Taipei, Taiwan
    Toxicol Appl Pharmacol 180:22-35. 2002
    ..Our study provides the novel mechanisms of antitumor effects of MIC and such results may have significant applications for cancer chemotherapy...
  54. ncbi request reprint Morphine-potentiated agonist-induced platelet aggregation through alpha2-adrenoceptors in human platelets
    Joen Rong Sheu
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan
    J Cardiovasc Pharmacol 40:743-50. 2002
    ....
  55. pmc Zerumbone suppresses IKKα, Akt, and FOXO1 activation, resulting in apoptosis of GBM 8401 cells
    Hsing Yu Weng
    Graduate Institute of Clinical Medicine, Taipei Medical University, NO, 250, Wu Hsing Street, 11031 Taipei, Taiwan
    J Biomed Sci 19:86. 2012
    ..In this study, we demonstrate that zerumbone induces apoptosis in human glioblastoma multiforme (GBM8401) cells and investigate the apoptotic mechanism...
  56. pmc Thrombin induced connective tissue growth factor expression in rat vascular smooth muscle cells via the PAR-1/JNK/AP-1 pathway
    Wen Chin Ko
    Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taiwan, China
    Acta Pharmacol Sin 33:49-56. 2012
    ..To investigate the signaling pathways involved in thrombin-induced connective tissue growth factor (CTGF) expression in rat vascular smooth muscle cells (VSMCs)...
  57. doi request reprint p53 in trichostatin A induced C6 glioma cell death
    Ya Fen Hsu
    Department of Surgery, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Biochim Biophys Acta 1810:504-13. 2011
    ..HDAC inhibitors have thus emerged as a new class of anti-tumor agents for various types of tumors. However, the mechanisms by which HDAC inhibition-induced cell death remain to be fully defined...
  58. doi request reprint Rac1 regulates peptidoglycan-induced nuclear factor-kappaB activation and cyclooxygenase-2 expression in RAW 264.7 macrophages by activating the phosphatidylinositol 3-kinase/Akt pathway
    Bing Chang Chen
    School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan
    Mol Immunol 46:1179-88. 2009
    ..7 macrophages...
  59. ncbi request reprint Antiplatelet activity of Staphylococcus aureus lipoteichoic acid is mediated through a cyclic AMP pathway
    J R Sheu
    Graduate Institute of Medical Sciences, Department of Pharmacology, Taipei Medical College, Taipei, Taiwan
    Thromb Res 99:249-58. 2000
    ..Therefore, LTA-mediated alteration of platelet function may contribute to bleeding diathesis in septicemic and endotoxemic patients...
  60. pmc NF-κB repressing factor inhibits chemokine synthesis by peripheral blood mononuclear cells and alveolar macrophages in active pulmonary tuberculosis
    Kuo Hsiung Huang
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
    PLoS ONE 8:e77789. 2013
    ..NRF may serve as an endogenous repressor to prevent robust increase in IP-10/CXCL10 and IL-8/CXCL8 when TB bacterial load is high. ..
  61. pmc Effect of theophylline and specific phosphodiesterase IV inhibition on proliferation and apoptosis of progenitor cells in bronchial asthma
    Chun Hua Wang
    Department of Thoracic Medicine II, Chang Gung Memorial Hospital, Taipei, Taiwan
    Br J Pharmacol 138:1147-55. 2003
    ..The anti-inflammatory properties of theophylline include an inhibition of circulating progenitor cells...
  62. ncbi request reprint Inhibitory mechanisms of tetramethylpyrazine in middle cerebral artery occlusion (MCAO)-induced focal cerebral ischemia in rats
    George Hsiao
    Graduate Institute of Pharmacology, Taipei Medical University, Taiwan, Republic of China
    Planta Med 72:411-7. 2006
    ..Thus, TMPZ treatment may represent an ideal approach to lowering the risk of or improving function in ischemia-reperfusion brain injury-related disorders...
  63. ncbi request reprint Platonin, a photosensitizing dye, improves circulatory failure and mortality in rat models of endotoxemia
    George Hsiao
    Department of Pharmacology, Taipei Medical University, Taiwan
    Biol Pharm Bull 25:995-9. 2002
    ..This protective effect of platonin may be mediated, at least partly, by the reduced drop in MAP and the inhibition of NO and free radical formation in rat models of endotoxemia...
  64. pmc Inhibition of mitochondria- and endoplasmic reticulum stress-mediated autophagy augments temozolomide-induced apoptosis in glioma cells
    Chien Ju Lin
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
    PLoS ONE 7:e38706. 2012
    ..This study provides evidence that agents targeting mitochondria or ER may be potential anticancer strategies...
  65. pmc Peptidoglycan induces cyclooxygenase-2 expression in macrophages by activating the neutral sphingomyelinase-ceramide pathway
    Bing Chang Chen
    School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
    J Biol Chem 284:20562-73. 2009
    ..The nSMase/ceramide pathway is required but might not be sufficient for COX-2 expression induced by PGN...
  66. ncbi request reprint Involvement of protein kinase C-gamma in IL-1beta-induced cyclooxygenase-2 expression in human pulmonary epithelial cells
    C H Lin
    Graduate Institutes of Biomedical Technology, Taipei Medical College, Taipei, Taiwan
    Mol Pharmacol 57:36-43. 2000
    ..Of the PKC isoforms present in A549 cells, only activation of PKC-gamma is involved in regulating IL-1beta-induced responses...
  67. doi request reprint Involvement of Ras/Raf-1/p44/42 MAPK in YC-1-induced cyclooxygenase-2 expression in human pulmonary epithelial cells
    Ming Shyan Chang
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
    Pharmacol Res 60:247-53. 2009
    ..Moreover, PKC-alpha and PI3K signal might be involved in YC-1-induced Raf-1 activation...
  68. doi request reprint Effects of E-cadherin (CDH1) gene promoter polymorphisms on the risk and clinicopathologic development of oral cancer
    Ming Hsien Chien
    Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan
    Head Neck 34:405-11. 2012
    ..This study investigates the association between polymorphism in the E-cadherin/CDH1 promoter region and the risk and progression of oral cancer...
  69. doi request reprint Tumor-associated carbonic anhydrase XII is linked to the growth of primary oral squamous cell carcinoma and its poor prognosis
    Ming Hsien Chien
    Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan
    Oral Oncol 48:417-23. 2012
    ..034, log-rank test) survival analysis. According to our results, the expression of CA XII in OSCC samples can predict the progression of OSCC and survival of OSCC patients...
  70. doi request reprint Zinc protoporphyrin inhibition of lipopolysaccharide-, lipoteichoic acid-, and peptidoglycan-induced nitric oxide production through stimulating iNOS protein ubiquitination
    Jyh Ming Chow
    Section of Hematology Oncology, Department of Internal Medicine, Taipei Municipal Wan Fang Hospital, Taipei Medical University, Taipei 110, Taiwan
    Toxicol Appl Pharmacol 237:357-65. 2009
    ..Data of the present study provide the first evidence to support ZnPP effectively inhibiting inflammatory iNOS/NO production through activation of protein ubiquitination in a HO-1-independent manner in macrophages...
  71. doi request reprint Thrombin induces cyclooxygenase-2 expression via the ERK and NF-kappaB pathways in human lung fibroblasts
    Chung Huang Shih
    Department of Respiratory Therapy, Taipei Medical University Hospital, Taipei, Taiwan
    Eur J Pharmacol 618:70-5. 2009
    ..Taken together, these results suggest that the ERK-dependent IKKalpha/beta/NF-kappaB signaling pathway plays an important role in thrombin-induced COX-2 expression in human lung fibroblasts...
  72. ncbi request reprint Involvement of nuclear factor-kappaB in lipoteichoic acid-induced cyclooxygenase-2 expression in RAW 264.7 macrophages
    L L Chiang
    School of Respiratory Therapy, Taipei Medical University, Taipei, Taiwan
    J Pharm Pharmacol 55:115-23. 2003
    ..The results suggested that lipoteichoic acid might have activated PC-PLC and PI-PLC to induce PKC activation, which in turn initiated NF-kappaB activation, and finally induced COX-2 expression in RAW 264.7 macrophages...
  73. ncbi request reprint Apoptosis signal-regulating kinase 1 in amyloid beta peptide-induced cerebral endothelial cell apoptosis
    Ming Jen Hsu
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei 110, Taiwan
    J Neurosci 27:5719-29. 2007
    ..Bax knockdown using a bax small interfering RNA strategy also reduced Bax expression and subsequent CEC death. These results suggest that Abeta activates the ASK1-p38MAPK-p53-Bax cascade to cause CEC death in a PP2A-dependent manner...
  74. doi request reprint Symptom clusters and relationships to symptom interference with daily life in Taiwanese lung cancer patients
    Shu Yi Wang
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan
    J Pain Symptom Manage 35:258-66. 2008
    ..These results provide an important basis for developing novel strategies to manage multiple symptoms in lung cancer patients and thereby improve their well-being...
  75. ncbi request reprint Inhibitory mechanisms of kinetin, a plant growth-promoting hormone, in platelet aggregation
    J R Sheu
    Graduate Institute of Medical Sciences, Taipei Medical University, Taiwan
    Platelets 14:189-96. 2003
    ..These results suggest that kinetin has an effective anti-platelet effect and that it may be a potential therapeutic agent for arterial thrombosis...
  76. pmc Apoptosis signal-regulating kinase 1 mediates denbinobin-induced apoptosis in human lung adenocarcinoma cells
    Chen Tzu Kuo
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan, ROC
    J Biomed Sci 16:43. 2009
    ..These results suggest that denbinobin might activate ASK1 through ROS production to cause JNK/AP-1 activation, which in turn induces Bim expression, and ultimately results in A549 cell apoptosis...
  77. ncbi request reprint Elevated expression of connective tissue growth factor in human atrial fibrillation and angiotensin II-treated cardiomyocytes
    Wen Chin Ko
    Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taiwan
    Circ J 75:1592-600. 2011
    ..Atrial fibrosis is a feature of structural remodeling in atrial fibrillation (AF). Connective tissue growth factor (CTGF) is a potent profibrotic factor, but its role of CTGF in AF is not yet fully understood...
  78. ncbi request reprint Mechanisms involved in the antiplatelet activity of magnesium in human platelets
    Joen Rong Sheu
    Graduate Institute of Medical Sciences and Department of Pharmacology, Taipei Medical University, Taipei, Taiwan
    Br J Haematol 119:1033-41. 2002
    ..2) Magnesium sulphate might also trigger the formation of cyclic AM, ultimately resulting in inhibition of the phosphorylation of P47 and intracellular Ca+2 mobilization...
  79. doi request reprint Neutrophil elastase represses IL-8/CXCL8 synthesis in human airway smooth muscle cells through induction of NF-kappa B repressing factor
    Shu Chuan Ho
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
    J Immunol 183:411-20. 2009
    ..Hence, we describe a novel negative regulatory mechanism of NE-induced NRF, which is restricted to hASM and mediates the suppression of IL-8/CXCL8 expression...
  80. doi request reprint Effects of E-cadherin (CDH1) gene promoter polymorphisms on the risk and clinicopathological development of hepatocellular carcinoma
    Ming Hsien Chien
    Taipei Medical University Wan Fang Hospital, Taipei, Taiwan
    J Surg Oncol 104:299-304. 2011
    ..Genetic polymorphisms of CDH1-160 and -347 were analyzed by PCR-RFLP genotyping analysis...
  81. ncbi request reprint Adolescent Internet usage in Taiwan: exploring gender differences
    Chien Huang Lin
    Department of Business Administration, National Central University, Taiwan, ROC
    Adolescence 43:317-31. 2008
    ..However, while girls tended to view the Internet more as a means of searching for information and e-mailing friends, boys tended to use it more for playing games and down-loading software...
  82. ncbi request reprint Byakangelicol, isolated from Angelica dahurica, inhibits both the activity and induction of cyclooxygenase-2 in human pulmonary epithelial cells
    C H Lin
    Graduate Institute of Biomedical Technology, Taipei Medical University, Taiwan
    J Pharm Pharmacol 54:1271-8. 2002
    ..Therefore, byakangelicol may have therapeutic potential as an anti-inflammatory drug on airway inflammation...
  83. ncbi request reprint Mechanisms in the inhibition of neointimal hyperplasia with triflavin in a rat model of balloon angioplasty
    J R Sheu
    Graduate Institute of Medical Sciences and Department of Pharmacology, Taipei Medical University, Taipei, Taiwan
    J Lab Clin Med 137:270-8. 2001
    ..These results provide new insights into the mechanisms of neointimal hyperplasia and have significant implications for disintegrin therapy for the treatment of restenosis and atherosclerosis...
  84. ncbi request reprint Griseofulvin potentiates antitumorigenesis effects of nocodazole through induction of apoptosis and G2/M cell cycle arrest in human colorectal cancer cells
    Y S Ho
    Institute of Biomedical Technology, Taipei Medical College, Taipei, Taiwan
    Int J Cancer 91:393-401. 2001
    ..These results suggest that chemotherapeutic agents (such as ND) administered in the presence of GF might provide a novel therapy for colorectal cancer...
  85. ncbi request reprint The effects of early postnatal dexamethasone therapy on pulmonary outcome in premature infants with respiratory distress syndrome: a two-year follow-up study
    Y J Lin
    Department of Paediatrics, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC
    Acta Paediatr 94:310-6. 2005
    ..To evaluate the pulmonary outcome at corrected age of 2 y on preterm infants who participated in a double-blind trial of early postnatal dexamethasone therapy (< 12 h after birth) for the prevention of chronic lung disease...
  86. ncbi request reprint Advanced glycosylation end products induce nitric oxide synthase expression in C6 glioma cells: involvement of a p38 MAP kinase-dependent mechanism
    C H Lin
    Graduate Institute of Biomedical Technology, Taipei Medical University, Taiwan, ROC
    Life Sci 69:2503-15. 2001
    ..Taken together, our data suggest that AGEs may activate the pathways of tyrosine kinase and Ras to induce p38 MAPK activation, which in turn induces iNOS expression and NO production in C6 glioma cells...
  87. pmc Pharmacological characteristics of liriodenine, isolated from Fissistigma glaucescens, a novel muscarinic receptor antagonist in guinea-pigs
    C H Lin
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei
    Br J Pharmacol 113:275-81. 1994
    ..It also acts as a blocker of voltage-dependent Ca2+ channels at a high concentration (300 microM).Keywords: Muscarinic receptor antagonist; Ca2+ channel blocker; guinea-pig trachea; liriodenine; Fissistigma glaucescens..
  88. ncbi request reprint Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo
    M G Wathelet
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Mol Cell 1:507-18. 1998
    ..These observations provide a unique example of the coordinate activation of multiple transcriptional activator proteins and their highly cooperative assembly into a transcriptional enhancer complex in vivo...
  89. ncbi request reprint A role for the PI-3 kinase signaling pathway in fear conditioning and synaptic plasticity in the amygdala
    C H Lin
    Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan City, Taiwan
    Neuron 31:841-51. 2001
    ..These results provide novel evidence of a requirement of PI-3 kinase activation in the amygdala for synaptic plasticity and memory consolidation, and this activation may occur at a point upstream of MAPK activation...
  90. ncbi request reprint Substrate-induced exposure of an energy-coupling motif of a membrane transporter
    H J Merianos
    Department of Chemistry and Biophysics Program, University of Virginia, Charlottesville 22901, USA
    Nat Struct Biol 7:205-9. 2000
    ..These data suggest that the TonB box extends into the periplasm and interacts with TonB only in..
  91. ncbi request reprint Modulation of voltage-dependent calcium currents by serotonin in acutely isolated rat amygdala neurons
    C H Lin
    Department of Pharmacology, College of Medicine, National Cheng-Kung University, Tainan City, Taiwan 701
    Synapse 41:351-9. 2001
    ..These results provide the first evidence showing a dominant effect of 5-HT-mediated inhibition over Iso-mediated enhancement of I(Ca)...
  92. ncbi request reprint Identification of a mouse thiamine transporter gene as a direct transcriptional target for p53
    P K Lo
    Institute of Biochemistry, National Yang Ming University, Shih Pai, Taipei 112, Taiwan
    J Biol Chem 276:37186-93. 2001
    ..Our findings indicate that p53 may be involved in maintaining thiamine homeostasis through transactivation of THTR-1...
  93. ncbi request reprint Genome-wide hypomethylation in hepatocellular carcinogenesis
    C H Lin
    Liver Research Unit, Chang Gung Memorial Hospital, 199 Tung-Hua North Road, Taipei, Taiwan 155
    Cancer Res 61:4238-43. 2001
    ..In addition, our results did not support the hypothesis of activation of transposable elements in HCC via genome-wide hypomethylation...
  94. ncbi request reprint Effect of antenatal dexamethasone on the expression of endothelial nitric oxide synthase in the lungs of postnatal pups
    C H Lin
    Department of Pediatrics and Physiology, Medical College National Cheng Kung University, Tainan, Taiwan
    Semin Perinatol 25:94-9. 2001
    ..We conclude that antenatal Dex therapy enhances the abundance of eNOS protein expression in the lung at birth and could be a factor in improving respiratory functions in infants who received antenatal steroid therapy...