Shih Chieh Hung

Summary

Affiliation: Taipei Veterans General Hospital
Country: Taiwan

Publications

  1. pmc RB maintains quiescence and prevents premature senescence through upregulation of DNMT1 in mesenchymal stromal cells
    Shih Pei Lin
    Institute of Clinical Medicine, National Yang Ming University, Taipei 112, Taiwan, ROC
    Stem Cell Reports 3:975-86. 2014
  2. pmc cAMP/PKA regulates osteogenesis, adipogenesis and ratio of RANKL/OPG mRNA expression in mesenchymal stem cells by suppressing leptin
    Der Chih Yang
    Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan
    PLoS ONE 3:e1540. 2008
  3. pmc Functional roles of pluripotency transcription factors in mesenchymal stem cells
    Chih Chien Tsai
    Institute of Clinical Medicine National Yang Ming University Taipei, Taiwan
    Cell Cycle 11:3711-2. 2012
  4. ncbi request reprint Influence of femoral lengthening on hip joint space in posttraumatic femoral shortening
    S C Hung
    Department of Orthopaedic Surgery, Faculty of Medicine, University of Tokyo, Japan
    Acta Orthop Scand 68:541-4. 1997
  5. ncbi request reprint Lineage differentiation-associated loss of adenoviral susceptibility and Coxsackie-adenovirus receptor expression in human mesenchymal stem cells
    Shih Chieh Hung
    Department of Orthopedics and Traumatology, Veterans General Hospital Taipei, Taipei, Taiwan
    Stem Cells 22:1321-9. 2004
  6. ncbi request reprint Gene expression profiles of early adipogenesis in human mesenchymal stem cells
    Shih Chieh Hung
    Department of Orthopaedics and Traumatology, Veterans General Hospital Taipei, 201, Sec 2, Shih Pai Road, Taipei 11217, Taiwan, ROC
    Gene 340:141-50. 2004
  7. ncbi request reprint Alpha-smooth muscle actin expression and structure integrity in chondrogenesis of human mesenchymal stem cells
    Shih Chieh Hung
    Department of Orthopaedics and Traumatology, Veterans General Hospital Taipei, 201 Sec 2, Shih Pai Road, 11217 Taipei, Taiwan, Republic of China
    Cell Tissue Res 324:457-66. 2006
  8. ncbi request reprint Immortalization without neoplastic transformation of human mesenchymal stem cells by transduction with HPV16 E6/E7 genes
    Shih Chieh Hung
    Department of Orthopedics and Traumatology, Veterans General Hospital Taipei, Taipei, Taiwan, ROC
    Int J Cancer 110:313-9. 2004
  9. pmc Short-term exposure of multipotent stromal cells to low oxygen increases their expression of CX3CR1 and CXCR4 and their engraftment in vivo
    Shih Chieh Hung
    Center for Gene Therapy, Tulane University Health Science Center, New Orleans, Louisiana, United States of America
    PLoS ONE 2:e416. 2007
  10. ncbi request reprint In vitro differentiation of size-sieved stem cells into electrically active neural cells
    Shih Chieh Hung
    Department of Orthopaedics, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Stem Cells 20:522-9. 2002

Detail Information

Publications87

  1. pmc RB maintains quiescence and prevents premature senescence through upregulation of DNMT1 in mesenchymal stromal cells
    Shih Pei Lin
    Institute of Clinical Medicine, National Yang Ming University, Taipei 112, Taiwan, ROC
    Stem Cell Reports 3:975-86. 2014
    ..These results demonstrate that RB expressed in early-passage MSCs upregulates DNMT1 expression and inhibits senescence in MSCs. Therefore, genetic modification of RB could be a way to improve the efficiency of MSCs in clinical use. ..
  2. pmc cAMP/PKA regulates osteogenesis, adipogenesis and ratio of RANKL/OPG mRNA expression in mesenchymal stem cells by suppressing leptin
    Der Chih Yang
    Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan
    PLoS ONE 3:e1540. 2008
    ..The reciprocal relationship between adipogenesis and osteogenesis was previously demonstrated; however, the mechanisms remain largely unknown...
  3. pmc Functional roles of pluripotency transcription factors in mesenchymal stem cells
    Chih Chien Tsai
    Institute of Clinical Medicine National Yang Ming University Taipei, Taiwan
    Cell Cycle 11:3711-2. 2012
    ..Comment on: Tsai CC, et al. Mol Cell 2012; 47:169-82...
  4. ncbi request reprint Influence of femoral lengthening on hip joint space in posttraumatic femoral shortening
    S C Hung
    Department of Orthopaedic Surgery, Faculty of Medicine, University of Tokyo, Japan
    Acta Orthop Scand 68:541-4. 1997
    ..03). Our findings indicate that femoral lengthening for posttraumatic femoral shortening should be done as early as possible to prevent the development of joint space narrowing during the lengthening procedure...
  5. ncbi request reprint Lineage differentiation-associated loss of adenoviral susceptibility and Coxsackie-adenovirus receptor expression in human mesenchymal stem cells
    Shih Chieh Hung
    Department of Orthopedics and Traumatology, Veterans General Hospital Taipei, Taipei, Taiwan
    Stem Cells 22:1321-9. 2004
    ..According to the present investigation, undifferentiated hMSCs can serve as a gene-delivering system, and gene transfer into hMSCs before differentiation can resolve the difficulties in transduction of their differentiated progeny...
  6. ncbi request reprint Gene expression profiles of early adipogenesis in human mesenchymal stem cells
    Shih Chieh Hung
    Department of Orthopaedics and Traumatology, Veterans General Hospital Taipei, 201, Sec 2, Shih Pai Road, Taipei 11217, Taiwan, ROC
    Gene 340:141-50. 2004
    ..Among them, 55 genes were not previously examined to associate with adipogenesis or have not been determined in hMSCs, therefore, these data provide novel information on the genes involved in adipogenesis of hMSCs...
  7. ncbi request reprint Alpha-smooth muscle actin expression and structure integrity in chondrogenesis of human mesenchymal stem cells
    Shih Chieh Hung
    Department of Orthopaedics and Traumatology, Veterans General Hospital Taipei, 201 Sec 2, Shih Pai Road, 11217 Taipei, Taiwan, Republic of China
    Cell Tissue Res 324:457-66. 2006
    ..The SMA-positive cells in the peripheral layers of the chondrogenic pellets mimic those within the superficial layer of articular cartilage and are speculated to play a major role in cartilage development and maintenance...
  8. ncbi request reprint Immortalization without neoplastic transformation of human mesenchymal stem cells by transduction with HPV16 E6/E7 genes
    Shih Chieh Hung
    Department of Orthopedics and Traumatology, Veterans General Hospital Taipei, Taipei, Taiwan, ROC
    Int J Cancer 110:313-9. 2004
    ..Our results indicated that hMSCs could be immortalized by transduction with HPV16 E6/E7, maintained without neoplastic transformation by careful culture procedures and thus useful for stem cell research and clinical application...
  9. pmc Short-term exposure of multipotent stromal cells to low oxygen increases their expression of CX3CR1 and CXCR4 and their engraftment in vivo
    Shih Chieh Hung
    Center for Gene Therapy, Tulane University Health Science Center, New Orleans, Louisiana, United States of America
    PLoS ONE 2:e416. 2007
    ..The results suggest that short-term culture of MSCs under hypoxic conditions may provide a general method of enhancing their engraftment in vivo into a variety of tissues...
  10. ncbi request reprint In vitro differentiation of size-sieved stem cells into electrically active neural cells
    Shih Chieh Hung
    Department of Orthopaedics, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Stem Cells 20:522-9. 2002
    ..These findings suggest that SS cells may be an alternative source of undifferentiated cells for cell therapy and gene therapy in neural dysfunction...
  11. ncbi request reprint Isolation and characterization of size-sieved stem cells from human bone marrow
    Shih Chieh Hung
    Department of Orthopaedics and Traumatology, Veterans General Hospital Taipei, Taiwan
    Stem Cells 20:249-58. 2002
    ..This technically simple method leads to an efficient isolation and purification of cells with the characteristics of MSCs...
  12. pmc Recapitulation of fibromatosis nodule by multipotential stem cells in immunodeficient mice
    Jung Pan Wang
    Institute of Clinical Medicine, School of Medicine, National Yang Ming University, Taipei, Taiwan
    PLoS ONE 6:e24050. 2011
    ..These results suggest that FSCs are the cellular origin of fibromatosis and that these cells may provide a promising model for developing new therapeutic interventions...
  13. doi request reprint Isolation of mesenchymal stem cells from human ligamentum flavum: implicating etiology of ligamentum flavum hypertrophy
    Yi Te Chen
    Department of Orthopedics, National Yang Ming University, Taipei, Taiwan
    Spine (Phila Pa 1976) 36:E1193-200. 2011
    ..To demonstrate the existence of mesenchymal stem cells (MSCs) in ligamentum flavum (LF) and their pathogenic role in LF hypertrophy...
  14. doi request reprint Fibromatosis stem cells rather than bone-marrow mesenchymal stem cells recapitulate a murine model of fibromatosis
    Jung Pan Wang
    Institute of Clinical Medicine, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Biochem Biophys Res Commun 408:269-75. 2011
    ..In summary, their myofibroblastic differentiation both in vivo and in vitro makes FSCs a potential cell source for future applications in murine models of fibromatosis or fibrogenesis...
  15. doi request reprint Cucurbitacin I inhibits tumorigenic ability and enhances radiochemosensitivity in nonsmall cell lung cancer-derived CD133-positive cells
    Han Shui Hsu
    Institute of Emergency and Critical Care Medicine, National Yang Ming University, Taipei, Taiwan, Republic of China
    Cancer 117:2970-85. 2011
    ..The objective of the current study was to investigate the effect of the strong STAT3 inhibitor, cucurbitacin I, in prominin-1 (CD133)-positive lung cancer cells...
  16. ncbi request reprint The internalized CdSe/ZnS quantum dots impair the chondrogenesis of bone marrow mesenchymal stem cells
    Shu Chen Hsieh
    Institute of Biomedical Engineering, National Yang Ming University, Shih Pai, Taipei, Taiwan, Republic of China
    J Biomed Mater Res B Appl Biomater 79:95-101. 2006
    ..Our results that the presence of QDs interferes with the chondrogenic differentiation of MSCs raise concerns in using the QDs as fluorescence tracers for stem cells...
  17. doi request reprint Enhancement of wound healing by human multipotent stromal cell conditioned medium: the paracrine factors and p38 MAPK activation
    Tu Lai Yew
    Institute of Oral Biology, Department of Dentistry, National Yang Ming University, Taipei, Taiwan
    Cell Transplant 20:693-706. 2011
    ..Thus, our data suggest MSCs promote wound healing through releasing a repertoire of paracrine factors via activation of p38 MAPK, and the CM-MSC may be applied to enhance wound healing...
  18. doi request reprint Knockdown of p21(Cip1/Waf1) enhances proliferation, the expression of stemness markers, and osteogenic potential in human mesenchymal stem cells
    Tu Lai Yew
    Department of Dentistry, Institute of Oral Biology, National Yang Ming University, Taipei 112, Taiwan
    Aging Cell 10:349-61. 2011
    ..Therefore, these data successfully demonstrate the involvement of senescence gene in the expression of stemness markers and osteogenic potential of MSCs...
  19. doi request reprint Scale-up of MSC under hypoxic conditions for allogeneic transplantation and enhancing bony regeneration in a rabbit calvarial defect model
    Tu Lai Yew
    Faculty of Dentistry, Institute of Oral Biology, National Yang Ming University, Taipei 112, Taiwan
    J Orthop Res 30:1213-20. 2012
    ....
  20. ncbi request reprint Fibronectin and pellet suspension culture promote differentiation of human mesenchymal stem cells into insulin producing cells
    Ching Fang Chang
    Stem Cell Laboratory, Department of Medical Research and Education, Veterans General Hospital Taipei, Taiwan
    J Biomed Mater Res A 86:1097-105. 2008
    ..Our data suggest that MSCs in the monolayer do not undergo IPC differentiation and pellet suspension culture with fibronectin promotes IPCs derived from MSCs...
  21. doi request reprint Colon cancer stem cells resist antiangiogenesis therapy-induced apoptosis
    Shih Pei Lin
    Institute of Clinical Medicine, Faculty of Medicine, National Yang Ming University, Taipei 112, Taiwan
    Cancer Lett 328:226-34. 2013
    ..Additionally, we identified an anti-apoptotic signaling pathway responsible for this resistance involving PP2A, p38MAPK, MAPKAPK2, and Hsp27. Thus, this pathway may offer a new avenue to develop target therapy for colorectal cancer...
  22. pmc Hypoxia enhances chondrogenesis and prevents terminal differentiation through PI3K/Akt/FoxO dependent anti-apoptotic effect
    Hsieh Hsing Lee
    1 Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei 100, Taiwan 2 Department of Orthopedics, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan 3 Department of Orthopedics, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan
    Sci Rep 3:2683. 2013
    ..These results suggest that the PI3K/Akt/FoxO survival pathway activated by hypoxia in MSCs enhances chondrogenesis and plays an important role in preventing endochondral ossification. ..
  23. doi request reprint Mesenchymal stem cells from a hypoxic culture improve and engraft Achilles tendon repair
    Tung Fu Huang
    Department of Surgery, Faculty of Medicine, National Yang Ming University, Taipei, Taiwan
    Am J Sports Med 41:1117-25. 2013
    ..Bone marrow-derived mesenchymal stem cells (MSCs) from humans cultured under hypoxic conditions increase bone healing capacity...
  24. ncbi request reprint Chondrogenesis of human mesenchymal stem cells encapsulated in alginate beads
    Hsiao Li Ma
    Department of Orthopaedics and Traumatology, Veterans General Hospital Taipei, 201, Sec 2, Shih Pai Road, Taipei, Taiwan
    J Biomed Mater Res A 64:273-81. 2003
    ..These results indicate MSCs in alginate can form cartilage and the MSCs-alginate system represents a relevant model for the study of the molecular mechanisms involved in the chondrogenesis and endochondral ossification...
  25. pmc Survival of cancer stem cells under hypoxia and serum depletion via decrease in PP2A activity and activation of p38-MAPKAPK2-Hsp27
    Shih Pei Lin
    Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan
    PLoS ONE 7:e49605. 2012
    ..Thus, activation of PP2A or inactivation of the p38MAPK-MAPKAPK2-Hsp27 pathway may develop new strategies for cancer therapy by suppression of their TIC population...
  26. ncbi request reprint Mesenchymal stem cells in the Wharton's jelly of the human umbilical cord
    Hwai Shi Wang
    Institute of Anatomy and Cell Biology, Yang Ming University, Taipei, Taiwan, Republic of China
    Stem Cells 22:1330-7. 2004
    ....
  27. pmc Fibronectin and laminin promote differentiation of human mesenchymal stem cells into insulin producing cells through activating Akt and ERK
    Hsiao Yun Lin
    Stem Cell Laboratory, Department of Medical Research and Education, Veterans General Hospital Taipei, Taiwan
    J Biomed Sci 17:56. 2010
    ..Bone marrow-derived multipotent mesenchymal stem cells (MSCs) offer renewable cells for generating insulin-producing cells (IPCs)...
  28. doi request reprint Clinical outcome and imaging of arthroscopic single-row and double-row rotator cuff repair: a prospective randomized trial
    Hsiao Li Ma
    National Yang Ming University School of Medicine, Taipei, Taiwan
    Arthroscopy 28:16-24. 2012
    ....
  29. doi request reprint Trichostatin A inhibits TGF-β1 induced in vitro chondrogenesis of hMSCs through Sp1 suppression
    Jung Pan Wang
    Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan
    Differentiation 81:119-26. 2011
    ..Furthermore, Sp1 could be a useful tool in future studies looking into biological mechanisms by which chondrogenesis of hMSCs can be augmented, especially in the area of clinical application...
  30. ncbi request reprint Angiogenic effects of human multipotent stromal cell conditioned medium activate the PI3K-Akt pathway in hypoxic endothelial cells to inhibit apoptosis, increase survival, and stimulate angiogenesis
    Shih Chieh Hung
    Center for Gene Therapy, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, Louisiana 70112, USA
    Stem Cells 25:2363-70. 2007
    ..The results are consistent with suggestions that administration of MSCs or factors secreted by MSCs may provide a therapeutic method of decreasing apoptosis and enhancing angiogenesis...
  31. doi request reprint Hypoxia inhibits senescence and maintains mesenchymal stem cell properties through down-regulation of E2A-p21 by HIF-TWIST
    Chih Chien Tsai
    Institute of Pharmacology, National Yang Ming University, Taipei, Taiwan
    Blood 117:459-69. 2011
    ..These results support low-density hypoxic culture as a method for efficiently expanding MSCs without losing stem cell properties or increasing tumorigenicity...
  32. ncbi request reprint Development of a new method in promoting fracture healing: multiple cryopreserved bone marrow injections using a rabbit model
    Hsiao Li Ma
    Department of Orthopaedics and Traumatology, Veterans General Hospital, 201, Sec 2, Shih Pai Road, Taipei, Taiwan
    Arch Orthop Trauma Surg 124:448-54. 2004
    ..It was hypothesized that multiple injections of cryopreserved bone marrow (BM) would promote fracture healing...
  33. ncbi request reprint Analysis of silibinin in rat plasma and bile for hepatobiliary excretion and oral bioavailability application
    Jhy Wen Wu
    Institute of Traditional Medicine, School of Medicine, National Yang Ming University, Taipei 112, Taiwan
    J Pharm Biomed Anal 45:635-41. 2007
    ..The oral bioavailability of silibinin in rats was estimated to be 0.73%...
  34. doi request reprint Isolation of mesenchymal stem cells from shoulder rotator cuff: a potential source for muscle and tendon repair
    Chih Chien Tsai
    Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan
    Cell Transplant 22:413-22. 2013
    ..These results demonstrate the successful isolation of MSCs from human rotator cuffs and encourage the application of RC-MSCs in myogenic regeneration...
  35. doi request reprint Oct4 and Nanog directly regulate Dnmt1 to maintain self-renewal and undifferentiated state in mesenchymal stem cells
    Chih Chien Tsai
    Institute of Pharmacology, Faculty of Medicine, National Yang Ming University, Taipei 112, Taiwan
    Mol Cell 47:169-82. 2012
    ..These data demonstrate the important roles of Oct4 and Nanog in maintaining MSC properties...
  36. doi request reprint Cationic polyurethanes-short branch PEI-mediated delivery of Mir145 inhibited epithelial-mesenchymal transdifferentiation and cancer stem-like properties and in lung adenocarcinoma
    Guang Yuh Chiou
    Institute of Pharmacology, National Yang Ming University, Taiwan
    J Control Release 159:240-50. 2012
    ..Our results demonstrated that miR145 acts as a switch regulating lung CSC-like and EMT properties, and provide insights into the clinical prospect of miR145-based therapies for malignant lung cancers...
  37. doi request reprint In vitro stage-specific chondrogenesis of mesenchymal stem cells committed to chondrocytes
    Wei Hong Chen
    Taipei Medical University, Taipei, Taiwan, Republic of China
    Arthritis Rheum 60:450-9. 2009
    ..This study was undertaken to establish a model for preconditioning of MSCs toward chondrogenesis as a more effective clinical tool for cartilage regeneration...
  38. doi request reprint Type I collagen promotes proliferation and osteogenesis of human mesenchymal stem cells via activation of ERK and Akt pathways
    Kuo Shu Tsai
    Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan
    J Biomed Mater Res A 94:673-82. 2010
    ..These data demonstrate that collagen I promotes proliferation and osteogenesis of hMSCs via activation of ERK and Akt pathways...
  39. doi request reprint Apoptosis in chondrogenesis of human mesenchymal stem cells: effect of serum and medium supplements
    Chien Yuan Wang
    Institute of Biomedical Engineering, National Yang Ming University, Taipei, Taiwan
    Apoptosis 15:439-49. 2010
    ..These data suggest apoptosis occurs during chondrogenesis by MSCs by cell death intrinsic pathway activation and this process may be modulated by culture conditions...
  40. doi request reprint Chondrogenesis from immortalized human mesenchymal stem cells: comparison between collagen gel and pellet culture methods
    Chih Hung Chang
    Department of Surgery, Division of Orthopedics, Far Eastern Memorial Hospital, Taipei, Taiwan
    Artif Organs 32:561-6. 2008
    ..These results indicate that the immortalized hMSC line is a promising tool for further in vitro chondrogenic studies...
  41. ncbi request reprint Three-dimensional collagen fiber remodeling by mesenchymal stem cells requires the integrin-matrix interaction
    Ching Fang Chang
    Stem Cell Laboratory, Medical Research and Education, Veterans General Hospital Taipei, 201, Sec 2, Shih Pai Road, 112 Taipei, Taiwan, Republic of China
    J Biomed Mater Res A 80:466-74. 2007
    ..This method for three-dimensional fabricating collagen fibers may generally be applied to other biomaterials, when combined with surface modification or ligand addition for cell adhesion...
  42. pmc Oct-4 expression maintained cancer stem-like properties in lung cancer-derived CD133-positive cells
    Yu Chih Chen
    Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan
    PLoS ONE 3:e2637. 2008
    ..Future research is warranted regarding the up-regulated expression of Oct-4 in LC-CD133(+) and malignant lung cancer...
  43. doi request reprint Mesenchymal stem cell-conditioned medium facilitates angiogenesis and fracture healing in diabetic rats
    Chien Yuan Wang
    Institute of Biomedical Engineering, National Yang Ming University, Taiwan, Republic of China
    J Tissue Eng Regen Med 6:559-69. 2012
    ..Together, these results indicated that gelatin sponges used to deliver MSC-CM promote angiogenesis and fracture healing in a diabetic model and may be an alternative strategy for treating fracture non-union in patients with diabetes...
  44. doi request reprint Silibinin suppresses the maintenance of colorectal cancer stem-like cells by inhibiting PP2A/AKT/mTOR pathways
    Jir You Wang
    Institute of Clinical Medicine, School of Medicine, National Yang Ming University, Taipei, Taiwan
    J Cell Biochem 113:1733-43. 2012
    ..Silibinin, which inhibits colon CSLCs self-renewal and sphere formation by suppressing the PP2Ac/AKT Ser473/mTOR pathway, may be a compound for developing new strategies in modulating CSLCs in cancer therapy...
  45. ncbi request reprint The reoperation of failed rotator cuff repairs
    Hsiao Li Ma
    Division of Sports Medicine, Department of Orthopedics, and Traumatology, Taipei Veterans General Hospital, and National Yang Ming University School of Medicine, Taipei, Taiwan, ROC
    J Chin Med Assoc 66:96-102. 2003
    ..In order to identify which factors are responsible for the failure of the initial surgery and which factors are correctable with reoperation, the results of surgical treatment for failed initial rotator cuff repair were analyzed...
  46. pmc Hypoxia inhibits osteogenesis in human mesenchymal stem cells through direct regulation of RUNX2 by TWIST
    Der Chih Yang
    Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan
    PLoS ONE 6:e23965. 2011
    ....
  47. pmc Twist controls skeletal development and dorsoventral patterning by regulating runx2 in zebrafish
    Der Chih Yang
    Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan
    PLoS ONE 6:e27324. 2011
    ....
  48. doi request reprint Repair of naphthalene-induced acute tracheal injury by basal cells depends on β-catenin
    Han Shui Hsu
    Institute of Emergency and Critical Care Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan Division of Thoracic Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan Electronic address
    J Thorac Cardiovasc Surg 148:322-32. 2014
    ..This study aimed to investigate the role of Wnt signaling in the self-renewal of basal cells and the involvement of β-catenin in tracheal repair after naphthalene-induced injury...
  49. doi request reprint Mesenchymal stem cells promote formation of colorectal tumors in mice
    Kuo Shu Tsai
    Institute of Anatomy and Cell Biology, National Yang Ming University, Taipei, Taiwan
    Gastroenterology 141:1046-56. 2011
    ..001% of the cells in colorectal or other types of tumors. Mesenchymal stem cells (MSCs) integrate into the colorectal tumor stroma; we investigated their involvement in tumor initiation...
  50. doi request reprint Docosahexaenoic acid promotes dopaminergic differentiation in induced pluripotent stem cells and inhibits teratoma formation in rats with Parkinson-like pathology
    Yuh Lih Chang
    Institute of Pharmacology, Faculty of Medicine, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Cell Transplant 21:313-32. 2012
    ..Therefore, our data suggest that DHA plays a crucial role in iPS differentiation into functional DA neurons and that this approach could provide a novel therapeutic approach for PD treatment...
  51. doi request reprint Arthroscopic pancapsular plication for multidirectional shoulder instability in overhead athletes
    Hsiao Li Ma
    Department of Orthopaedics, Taipei Veterans General Hospital, Taipei, Taiwan
    Orthopedics 35:e497-502. 2012
    ..However, the low rate of return to a full level of overhead sports is a problem. Further evaluation of the benefits of this procedure for overhead athletes with symptomatic multidirectional instability is needed...
  52. pmc Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells
    Chen Chi Liu
    Institute of Clinical Medicine, National Yang Ming University, Taipei 112, Taiwan
    Nat Commun 7:11798. 2016
    ..Finally, this signalling axis enhances the ability of TIC to form tumours in mouse models of malignant lung cancer pleural effusion and spontaneous colon cancer metastasis. ..
  53. doi request reprint IL-6 enriched lung cancer stem-like cell population by inhibition of cell cycle regulators via DNMT1 upregulation
    Chen Chi Liu
    Institute of Clinical Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan Department of Emergency, Taipei Veterans General Hospital, Taipei, Taiwan
    Int J Cancer 136:547-59. 2015
    ..These data suggest that targeting of the IL-6/JAK2/STAT3 signaling pathway and DNMT1 may become important strategies for treating lung cancer. ..
  54. pmc Manipulation under anaesthesia for frozen shoulder in patients with and without non-insulin dependent diabetes mellitus
    Jung Pan Wang
    Department of Orthopaedics and Traumatology, Taipei Veterans General Hospital and National Yang Ming University, Taiwan, Republic of China
    Int Orthop 34:1227-32. 2010
    ..Even though DM is a predisposing factor to frozen shoulder, non-insulin dependent DM alone does not influence both the short- and long-term outcomes of frozen shoulder...
  55. doi request reprint Surgical treatment for septic arthritis of the knee joint in elderly patients: a 10-year retrospective clinical study
    Chao Ming Chen
    epartment of Orthopedics and Traumatology, Taipei Veterans General Hospital, Taiwan, Republic of China
    Orthopedics 36:e434-43. 2013
    ..These findings shed new light on the management of septic arthritis. Accurate diagnoses and effective treatments are important for the clinical outcome of knee joint bacterial infection in elderly patients...
  56. ncbi request reprint Osteochondral autografts transfer for post-traumatic osteochondral defect of the knee-2 to 5 years follow-up
    Hsiao Li Ma
    Department of Orthopaedics and Traumatology, Division of Sports Medicine, Taipei Veteran General Hospital, National Yang Ming University, No 201, Section 2, Shih Pai Road, Taipei 112, Taiwan
    Injury 35:1286-92. 2004
    ..The biopsy revealed survival of hyaline cartilage. For small to medium osteochondral lesion over the femoral condyle of the knee in selected patients, osteochondral autografting yielded promising short to mid-term results...
  57. ncbi request reprint Signalling pathway in the induction of neurite outgrowth in human mesenchymal stem cells
    Mien Sheng Chu
    Stem Cell Laboratory, Medical Research and Education, Veterans General Hospital Taipei, Taipei, Taiwan, ROC
    Cell Signal 18:519-30. 2006
    ....
  58. ncbi request reprint Neocartilage from human mesenchymal stem cells in alginate: implied timing of transplantation
    Hsiao Li Ma
    Department of Orthopaedics and Traumatology, Veterans General Hospital Taipei, Taipei, 11217, Taiwan
    J Biomed Mater Res A 74:439-46. 2005
    ..These findings suggested that regeneration using cell therapy or tissue engineering should assist in ascertaining the optimal timing of transplantation...
  59. ncbi request reprint Sodium butyrate activates ERK to regulate differentiation of mesenchymal stem cells
    Tain Hsiung Chen
    Orthopaedics and Traumatology, Veterans General Hospital, Taipei, Taiwan
    Biochem Biophys Res Commun 355:913-8. 2007
    ..Our results suggest that sodium butyrate modulates MSC differentiation and the RANKL/OPG ratio via activating ERK, and could be applied for in vivo bone growth using MSCs...
  60. doi request reprint c-Jun N-terminal kinase 1 negatively regulates osteoblastic differentiation induced by BMP2 via phosphorylation of Runx2 at Ser104
    Yi feng Huang
    Department of Life Sciences, Institute of Biopharmaceutical Sciences, National Yang Ming University, Taipei 112, Taiwan
    J Bone Miner Res 27:1093-105. 2012
    ..In addition, unraveling these mechanisms may help to develop new strategies in enhancing osteoblastic differentiation and bone formation...
  61. doi request reprint Collagen IV significantly enhances migration and transplantation of embryonic stem cells: involvement of α2β1 integrin-mediated actin remodeling
    Hsin Yang Li
    Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan
    Cell Transplant 20:893-907. 2011
    ....
  62. ncbi request reprint Open Bankart repair with suture anchors for traumatic recurrent anterior shoulder instability: comparison of results between small and large Bankart lesions
    Davy Lai
    Department of Orthopaedics and Traumatology, Taipei Veterans General Hospital, No 201, Sec 2, Shih Pai Road, Taipei, 11217, Taiwan
    Knee Surg Sports Traumatol Arthrosc 14:82-7. 2006
    ..The size of the Bankart lesion was a factor affecting surgical outcome. Small Bankart lesions usually got better results than large Bankart lesions...
  63. doi request reprint Collagen XVII/laminin-5 activates epithelial-to-mesenchymal transition and is associated with poor prognosis in lung cancer
    Chen Chi Liu
    Institute of Clinical Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan
    Oncotarget . 2016
    ..Our findings suggested that targeting Col XVII and laminin-5 could be novel therapeutic strategies for treating lung cancer patients, and warrant further investigation...
  64. pmc Allogeneic Mesenchymal Stem Cells in Combination with Hyaluronic Acid for the Treatment of Osteoarthritis in Rabbits
    En Rung Chiang
    Institute of Clinical Medicine, National Yang Ming University, Taipei 112, Taiwan
    PLoS ONE 11:e0149835. 2016
    ..Furthermore, engraftment of allogenic MSCs were evident in surface cartilage. Thus, injection of the allogeneic MSCs reduced the progression of osteoarthritis in vivo. ..
  65. doi request reprint Multi-lineage differentiation and angiogenesis potentials of pigmented villonodular synovitis derived mesenchymal stem cells--pathological implication
    En Rung Chiang
    Institute of Clinical Medicine, School of Medicine, National Yang Ming University, Taipei, Taiwan
    J Orthop Res 34:395-403. 2016
    ..In summary, the identification of PVNS-SCs in PVNS tissue and their distinct angiogenic potential may help elucidate the underlying etiology of this disease...
  66. pmc Comparison of idiopathic, post-trauma and post-surgery frozen shoulder after manipulation under anesthesia
    Jung Pan Wang
    Department of Orthopaedics and Traumatology, Veterans General Hospital Taipei and National Yang Ming University, Taipei, Taiwan, Republic of China
    Int Orthop 31:333-7. 2007
    ..Although less improvement in pain and ROM was noted, manipulation is still a good and simple way to treat post-surgery frozen shoulders...
  67. doi request reprint Efficient expansion of mesenchymal stem cells from mouse bone marrow under hypoxic conditions
    Tu Lai Yew
    Institute of Oral Biology, National Yang Ming University, Taipei, Taiwan Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan Institute of Anatomy and Cell Biology, National Yang Ming University, Taipei, Taiwan
    J Tissue Eng Regen Med 7:984-93. 2013
    ..In conclusion, we have developed a robust method for isolation and expansion of mMSCs by combining low-density culture with hypoxic culture...
  68. ncbi request reprint Imaging evaluation of meniscal injury of the knee joint: a comparative MR imaging and arthroscopic study
    Cheng Yen Chang
    Department of Radiology, Taipei Veterans General Hospital, Taipei 11217, Taiwan
    Clin Imaging 28:372-6. 2004
    ..Type VI meniscal tear was the most common type, especially in displaced meniscal tear. MR is a reliable diagnostic tool for meniscal tears and associated cruciate ligament injury...
  69. ncbi request reprint The inhibition of osteogenesis with human bone marrow mesenchymal stem cells by CdSe/ZnS quantum dot labels
    Shu Chen Hsieh
    Institute of Biomedical Engineering, National Yang Ming University, Taipei 112, Taiwan
    Biomaterials 27:1656-64. 2006
    ..Together our results show that the presence of QDs in hBMSCs prevents the full response of the cells to induced osteogenic differentiation...
  70. ncbi request reprint Thermal effects after anterior cruciate ligament shrinkage using radiofrequency technology: a porcine cadaver study
    Hsiao Li Ma
    Department of Orthopaedics and Traumatology, Veterans General Hospital Taipei, 201, Sec 2, Shih Pai Road, Taipei, 11217, Taiwan
    Knee Surg Sports Traumatol Arthrosc 13:619-24. 2005
    ..RF-generated thermocoagulation resulted in ACL shortening with significant changes on histological findings but not on initial biomechanical properties...
  71. doi request reprint Chemoresistance of lung cancer stemlike cells depends on activation of Hsp27
    Han Shui Hsu
    Institute of Emergency and Critical Care Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan
    Cancer 117:1516-28. 2011
    ..In the current study, the authors sought to identify the molecular mechanisms underlying the chemoresistance of lung cancer stem or initiation cells (cancer stem cells)...
  72. ncbi request reprint Rotator cuff tears in patients younger than 50 years of age
    Yi Pin Lin
    Department of Orthopaedics and Traumatology, Taipei Veterans General Hospital and National Yang Ming University, Taiwan
    Acta Orthop Belg 78:592-6. 2012
    ..The findings suggest that a good outcome after early repair in younger patients with traumatic rotator cuff tears can be expected...
  73. doi request reprint Hamstring graft sizes differ between Chinese and Caucasians
    En Rung Chiang
    Departments of Orthopaedics and Traumatology, Taipei Veterans General Hospital, No 201, Sec 2, Shih Pai Road, Shih Pai, Taipei, 112, Taiwan
    Knee Surg Sports Traumatol Arthrosc 20:916-21. 2012
    ..The purposes of this study were to determine whether anthropomorphic measurement correlated with tendon sizes in Chinese patient group and whether tendon sizes in Chinese and Caucasian patient groups differed...
  74. pmc Overexpression of hTERT increases stem-like properties and decreases spontaneous differentiation in human mesenchymal stem cell lines
    Chih Chien Tsai
    Stem Cell Laboratory, Department of Medical Research and Education and Orthopaedics and Traumatology, Veterans General Hospital, Taipei, Taiwan
    J Biomed Sci 17:64. 2010
    ....
  75. ncbi request reprint Monteggia type I equivalent lesion: diaphyseal ulna and radius fractures with a posterior elbow dislocation in an adult
    Shih Chieh Hung
    Department of Orthopaedics and Traumatology, Veterans General Hospital, Taipei, Taiwan
    Arch Orthop Trauma Surg 123:311-3. 2003
    ..The probable mechanisms of injury are speculated to include flexion of the elbow and pronation of the forearm...
  76. doi request reprint Arthroscopic treatment for pigmented villonodular synovitis of the shoulder associated with massive rotator cuff tear
    En Rung Chiang
    Department of Orthopaedics, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China
    Arthroscopy 25:716-21. 2009
    ..Our purpose was to investigate arthroscopic treatment of patients diagnosed with pigmented villonodular synovitis (PVNS) of the shoulder and massive rotator cuff tear with the initial presentation of large, recurrent joint effusion...
  77. doi request reprint Bilateral stress fractures of the ulna in a young adolescent
    Hsi Hsien Lin
    Department of Orthopaedics and Traumatology, Taipei Veterans General Hospital, School of Medicine, National Yang Ming University, Taiwan, ROC
    J Pediatr Orthop B 21:520-4. 2012
    ..Thus, such fractures are best managed by avoiding overloading. In addition, we review the literature on stress fractures of the ulnar shaft to map this special kind of fracture...
  78. ncbi request reprint Hepatobiliary excretion of silibinin in normal and liver cirrhotic rats
    Jhy Wen Wu
    Institute of Traditional Medicine, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Drug Metab Dispos 36:589-96. 2008
    ..These results together suggest that the phase II conjugative reaction of silibinin was blocked by treatment with DNM...
  79. pmc Identification of CD133-positive radioresistant cells in atypical teratoid/rhabdoid tumor
    Shih Hwa Chiou
    Department of Medical Research and Education, Taipei Veterans General Hospital and National Yang Ming University, Taipei, Taiwan
    PLoS ONE 3:e2090. 2008
    ....
  80. pmc Benefits of hypoxic culture on bone marrow multipotent stromal cells
    Chih Chien Tsai
    Institute of Clinical Medicine, National Yang Ming University Taipei 112, Taiwan Stem Cell Laboratory, Department of Medical Research and Education, Taipei Veterans General Hospital Taipei 112, Taiwan
    Am J Blood Res 2:148-59. 2012
    ..This review emphasizes that hypoxia is an important factor in all major aspects of stem cell biology, and the mechanism involved in the hypoxic inducible factor-1signaling pathway behind these responses is also discussed...
  81. ncbi request reprint Accumulation of mitochondrial DNA with 4977-bp deletion in knee cartilage--an association with idiopathic osteoarthritis
    Ming Chau Chang
    Department of Orthopedics and Traumatology, Taipei Veterans General Hospital, and Department of Surgery, National Yang Ming University, Taipei, Taiwan 112, Republic of China
    Osteoarthritis Cartilage 13:1004-11. 2005
    ..Since mitochondrial DNA (mtDNA) mutations have been established to associate with the aging process and some degenerative diseases, we investigated the correlation between idiopathic osteoarthritis (OA) and the 4977-bp mtDNA deletion...
  82. doi request reprint Cardiac myocyte progenitors from adult hearts for myocardial regenerative therapy
    Chia Feng Yang
    Department of Pediatrics, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    J Chin Med Assoc 71:79-85. 2008
    ..Proposed experimental reparative strategies include harvesting potent cells followed by direct injection into ischemic myocardium to achieve myogenesis and angiogenesis...
  83. doi request reprint Correlations among mineral components, progressive calcification process and clinical symptoms of calcific tendonitis
    Hong Jen Chiou
    Department of Biotechnology, Yuanpei University, Taiwan, Republic of China
    Rheumatology (Oxford) 49:548-55. 2010
    ..To establish the correlations among the mineral components, progressive calcification process and clinical symptoms of calcific tendonitis...
  84. doi request reprint The therapeutic potential of human umbilical mesenchymal stem cells from Wharton's jelly in the treatment of rat liver fibrosis
    Pei Chun Tsai
    Institute of Anatomy and Cell Biology, School of Medicine, National Yang Ming University, Taipei, Taiwan, Republic of China
    Liver Transpl 15:484-95. 2009
    ..Our findings suggest that xenogeneic transplantation of HUMSCs is a novel approach for treating liver fibrosis and may be a promising therapeutic intervention in the future...
  85. ncbi request reprint Mesenchymal stem cell targeting of microscopic tumors and tumor stroma development monitored by noninvasive in vivo positron emission tomography imaging
    Shih Chieh Hung
    Institute of Biomedical Sciences, Academia Sinica, Nankang, Taiwan
    Clin Cancer Res 11:7749-56. 2005
    ....
  86. ncbi request reprint Neuronal morphological change of size-sieved stem cells induced by neurotrophic stimuli
    Shun Fen Tzeng
    Department of Biology, National Cheng Kung University, Tainan City, Taiwan ROC
    Neurosci Lett 367:23-8. 2004
    ..The findings indicate that neurotrophic signaling and cAMP-dependent signaling might promote the neuronal differentiation of SSCs...