George Hsiao

Summary

Affiliation: Taipei Medical University
Country: Taiwan

Publications

  1. doi Histone Deacetylase Inhibitor Impairs Plasminogen Activator Inhibitor-1 Expression via Inhibiting TNF- α -Activated MAPK/AP-1 Signaling Cascade
    Wei Lin Chen
    Graduate Institute of Medical Sciences and Department of Pharmacology, College of Medicine, Taipei Medical University, 250 Wu Hsing Street, Taipei 110 31, Taiwan
    Biomed Res Int 2014:231012. 2014
  2. doi Histone deacetylase inhibitor m-carboxycinnamic acid bis-hydroxamide attenuates plasminogen activator inhibitor-1 expression in human pleural mesothelial cells
    Chi Li Chung
    Division of Pulmonary Medicine, Department of Internal Medicine, Taipei Medical University Hospital, Taiwan
    Am J Respir Cell Mol Biol 46:437-45. 2012
  3. pmc Neuroprotective mechanisms of puerarin in middle cerebral artery occlusion-induced brain infarction in rats
    Yi Chang
    Department of Anesthesiology, Shin Kong Wu Ho Su Memorial Hospital and School of Medicine, Fu Jen Catholic University, Taipei, Taiwan
    J Biomed Sci 16:9. 2009
  4. ncbi Protective mechanisms of inosine in platelet activation and cerebral ischemic damage
    George Hsiao
    Graduate Institute of Medical Sciences, Taipei Medical University, No 250, Wu Hsing Street, Taipei 110, Taiwan
    Arterioscler Thromb Vasc Biol 25:1998-2004. 2005
  5. ncbi Inhibitory mechanisms of resveratrol in platelet activation: pivotal roles of p38 MAPK and NO/cyclic GMP
    Ming Y Shen
    Graduate Institute of Medical Sciences and Topnotch Stroke Research Centre, Taipei Medical University, Taipei, Taiwan
    Br J Haematol 139:475-85. 2007
  6. ncbi Inhibitory effects of lycopene on in vitro platelet activation and in vivo prevention of thrombus formation
    George Hsiao
    Graduate Institute of Pharmacology, Taipei Medical University, Taipei, Taiwan
    J Lab Clin Med 146:216-26. 2005
  7. pmc Cyclic nucleotides and mitogen-activated protein kinases: regulation of simvastatin in platelet activation
    Ye Ming Lee
    Department of Pharmacology, Taipei Medical University, Taipei, Taiwan
    J Biomed Sci 17:45. 2010
  8. ncbi alpha-Naphthoflavone, a potent antiplatelet flavonoid, is mediated through inhibition of phospholipase C activity and stimulation of cyclic GMP formation
    George Hsiao
    Graduate Institute of Pharmacology and Graduate Institute of Medical Sciences, Taipei Medical University, Taiwan
    J Agric Food Chem 53:5179-86. 2005
  9. doi Potent antiplatelet activity of sesamol in an in vitro and in vivo model: pivotal roles of cyclic AMP and p38 mitogen-activated protein kinase
    Chao C Chang
    Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei 110, Taiwan
    J Nutr Biochem 21:1214-21. 2010
  10. doi A novel role of andrographolide, an NF-kappa B inhibitor, on inhibition of platelet activation: the pivotal mechanisms of endothelial nitric oxide synthase/cyclic GMP
    Wan Jung Lu
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
    J Mol Med (Berl) 89:1261-73. 2011

Collaborators

  • Joen Rong Sheu
  • Chien Huang Lin
  • Yi Chang
  • Tzong Huei Lee
  • Yu Wen Cheng
  • Ying Wang
  • Yueh Hsiung Kuo
  • Yen Mei Lee
  • Geng Chang Yeh
  • Wen Sen Lee
  • Duen Suey Chou
  • Chi Li Chung
  • Kuan H Lin
  • Yung Chen Chou
  • Thanasekaran Jayakumar
  • Duen S Chou
  • Wei Lin Chen
  • Che Jen Hsiao
  • Ming Yi Shen
  • Wan J Lu
  • Cheng Ying Hsieh
  • Tsorng H Fong
  • Ming Y Shen
  • Shih hsin Hsiao
  • Yan Jyu Tsai
  • Wan Jung Lu
  • Ming Jen Hsu
  • Tzeng Fu Chen
  • Sy Ping Chen
  • Tsorng Harn Fong
  • Chia Chun Yu
  • Ting Lin Yen
  • Ming J Hsu
  • Cheng Y Hsieh
  • Chao C Chang
  • Tsorng Han Fong
  • Kwok Keung Lam
  • Jie Jen Lee
  • Chi Feng Pan
  • Ching Kuo Lee
  • Hwa Wen Yin
  • Gong Jhe Wu
  • Meng Lun Chang
  • Jih Hwa Guh
  • Chung King Hsu
  • Pi Yu Chen
  • Yen Ju Chan
  • Ching Ruey Hsieh
  • Po Jen Hsueh
  • Shiuan W Chen
  • Pei T Chiu
  • Chi W Huang
  • Yi H Chiu
  • Fan Li Lin
  • Chien Liang Liu
  • Jie J Lee
  • Cheng W Chiang
  • Chung Yung Chen
  • Eng T Ong
  • Chiao Y Fan
  • Shu Ying Chen
  • Hsiu C Chou
  • Huai C Chang
  • Hsin Hsueh Shen
  • Yan An Lai
  • Shi Chuan Chang
  • Pao Yun Cheng
  • Chwen M Shih
  • Mao Hsiung Yen
  • Hsiang Erh Liu
  • Chung Y Hsu
  • Hui M Chen
  • Chang L Liu
  • Chih Jen Wu
  • Kuang H Lin
  • Chih Hsiang Chan
  • Tzu Yung Lin
  • Ching Yuan Lai
  • Aming Chor Ming Lin

Detail Information

Publications49

  1. doi Histone Deacetylase Inhibitor Impairs Plasminogen Activator Inhibitor-1 Expression via Inhibiting TNF- α -Activated MAPK/AP-1 Signaling Cascade
    Wei Lin Chen
    Graduate Institute of Medical Sciences and Department of Pharmacology, College of Medicine, Taipei Medical University, 250 Wu Hsing Street, Taipei 110 31, Taiwan
    Biomed Res Int 2014:231012. 2014
    ..Given the antifibrotic effect through PAI-1 abrogation, CBHA may be utilized as a novel agent in the treatment of fibrotic diseases. ..
  2. doi Histone deacetylase inhibitor m-carboxycinnamic acid bis-hydroxamide attenuates plasminogen activator inhibitor-1 expression in human pleural mesothelial cells
    Chi Li Chung
    Division of Pulmonary Medicine, Department of Internal Medicine, Taipei Medical University Hospital, Taiwan
    Am J Respir Cell Mol Biol 46:437-45. 2012
    ..Given the down-regulating effect of CBHA on PAI-1 expression, HDAC inhibitors should be tested further in animal models as potential therapeutic agents for pleural fibrosis...
  3. pmc Neuroprotective mechanisms of puerarin in middle cerebral artery occlusion-induced brain infarction in rats
    Yi Chang
    Department of Anesthesiology, Shin Kong Wu Ho Su Memorial Hospital and School of Medicine, Fu Jen Catholic University, Taipei, Taiwan
    J Biomed Sci 16:9. 2009
    ..Thus, puerarin treatment may represent a novel approach to lowering the risk of or improving function in ischemia-reperfusion brain injury-related disorders...
  4. ncbi Protective mechanisms of inosine in platelet activation and cerebral ischemic damage
    George Hsiao
    Graduate Institute of Medical Sciences, Taipei Medical University, No 250, Wu Hsing Street, Taipei 110, Taiwan
    Arterioscler Thromb Vasc Biol 25:1998-2004. 2005
    ..In the present study, we further investigated the inhibitory effects of inosine on platelet activation in vitro and in vivo, as well as in attenuating middle cerebral artery occlusion (MCAO)-induced focal cerebral ischemia in rats...
  5. ncbi Inhibitory mechanisms of resveratrol in platelet activation: pivotal roles of p38 MAPK and NO/cyclic GMP
    Ming Y Shen
    Graduate Institute of Medical Sciences and Topnotch Stroke Research Centre, Taipei Medical University, Taipei, Taiwan
    Br J Haematol 139:475-85. 2007
    ..Resveratrol is likely to exert significant protective effects in thromboembolic-related disorders by inhibiting platelet aggregation...
  6. ncbi Inhibitory effects of lycopene on in vitro platelet activation and in vivo prevention of thrombus formation
    George Hsiao
    Graduate Institute of Pharmacology, Taipei Medical University, Taipei, Taiwan
    J Lab Clin Med 146:216-26. 2005
    ..The results may imply that tomato-based foods are especially beneficial in the prevention of platelet aggregation and thrombosis...
  7. pmc Cyclic nucleotides and mitogen-activated protein kinases: regulation of simvastatin in platelet activation
    Ye Ming Lee
    Department of Pharmacology, Taipei Medical University, Taipei, Taiwan
    J Biomed Sci 17:45. 2010
    ..Although the inhibitory effect of simvastatin in platelet activation has been studied; the detailed signal transductions by which simvastatin inhibit platelet activation has not yet been completely resolved...
  8. ncbi alpha-Naphthoflavone, a potent antiplatelet flavonoid, is mediated through inhibition of phospholipase C activity and stimulation of cyclic GMP formation
    George Hsiao
    Graduate Institute of Pharmacology and Graduate Institute of Medical Sciences, Taipei Medical University, Taiwan
    J Agric Food Chem 53:5179-86. 2005
    ..These results strongly indicate that alpha-NF appears to represent a novel and potent antiplatelet agent for treatment of arterial thromboembolism...
  9. doi Potent antiplatelet activity of sesamol in an in vitro and in vivo model: pivotal roles of cyclic AMP and p38 mitogen-activated protein kinase
    Chao C Chang
    Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei 110, Taiwan
    J Nutr Biochem 21:1214-21. 2010
    ..Sesamol treatment may represent a novel approach to lowering the risk of or improving function in thromboembolism-related disorders...
  10. doi A novel role of andrographolide, an NF-kappa B inhibitor, on inhibition of platelet activation: the pivotal mechanisms of endothelial nitric oxide synthase/cyclic GMP
    Wan Jung Lu
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
    J Mol Med (Berl) 89:1261-73. 2011
    ....
  11. doi Arsenic trioxide-mediated antiplatelet activity: pivotal role of the phospholipase C gamma 2-protein kinase C-p38 MAPK cascade
    Kuan H Lin
    Graduate Institute of Medical Sciences, Department of Pharmacology, Taipei Medical University, Taipei, Taiwan
    Transl Res 155:97-108. 2010
    ....
  12. doi Expression of amyloid beta peptide in human platelets: pivotal role of the phospholipase Cgamma2-protein kinase C pathway in platelet activation
    Ming Yi Shen
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan
    Pharmacol Res 57:151-8. 2008
    ....
  13. ncbi Inhibitory mechanisms of low concentrations of oxidized low-density lipoprotein on platelet aggregation
    Duen Suey Chou
    Graduate Institute of Medical Sciences, Taipei Medical University, Taiwan, ROC
    J Biomed Sci 13:333-43. 2006
    ..This study further provides new insights concerning the effects of low concentrations of oxLDL on platelet aggregation...
  14. ncbi C-phycocyanin, a very potent and novel platelet aggregation inhibitor from Spirulina platensis
    George Hsiao
    Graduate Institute of Pharmacology, and Graduate Institute of Medical Sciences, Taipei Medical University, Taipei 110, Taiwan
    J Agric Food Chem 53:7734-40. 2005
    ..These results strongly indicate that C-PC appears to represent a novel and potential antiplatelet agent for treatment of arterial thromboembolism...
  15. doi Suppression of matrix metalloproteinase-9 expression by andrographolide in human monocytic THP-1 cells via inhibition of NF-κB activation
    Woan Ruoh Lee
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Department of Dermatology, Taipei Medical University Hospital and Department of Dermatology, Taipei Medical University Shuang Ho Hospital, Taipei 11031, Taiwan
    Phytomedicine 19:270-7. 2012
    ..These results provide new opportunities for the development of new anti-inflammatory and leukemic therapies...
  16. doi Suppression of NF-κB signaling by andrographolide with a novel mechanism in human platelets: regulatory roles of the p38 MAPK-hydroxyl radical-ERK2 cascade
    Wan J Lu
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
    Biochem Pharmacol 84:914-24. 2012
    ..Therefore, andrographolide may have a high therapeutic potential to treat thromboembolic disorders and may also be considered for treating various inflammatory diseases...
  17. ncbi Inhibitory mechanisms of gabapentin, an antiseizure drug, on platelet aggregation
    Chi Feng Pan
    Graduate Institute of Medical Sciences and Topnotch Stroke Research Center, Taipei Medical University, Taipei, Taiwan
    J Pharm Pharmacol 59:1255-61. 2007
    ..Thus, it is possible that gabapentin treatment, alone or in combination with other antiplatelet drugs, may induce or potentiate inhibition of platelet aggregation, which may affect haemostasis in-vivo...
  18. ncbi Characterization of a novel and potent collagen antagonist, caffeic acid phenethyl ester, in human platelets: in vitro and in vivo studies
    George Hsiao
    Graduate Institute of Pharmacology, Taipei Medical University, Taipei, Taiwan
    Cardiovasc Res 75:782-92. 2007
    ..In the present study, CAPE (6-25 microM) specifically inhibited collagen-induced platelet aggregation and the ATP release reaction in platelet suspensions...
  19. doi Comparison of the relative activities of inducing platelet apoptosis stimulated by various platelet-activating agents
    Kuan H Lin
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei 110, Taiwan
    Platelets 20:575-81. 2009
    ..The in vivo physiological function of the apoptotic machinery in platelets is not yet clearly understood, and needs to be further investigated in the future...
  20. ncbi Neuroprotective effects of PMC, a potent alpha-tocopherol derivative, in brain ischemia-reperfusion: reduced neutrophil activation and anti-oxidant actions
    George Hsiao
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan
    Biochem Pharmacol 73:682-93. 2007
    ..Thus, PMC treatment may represent a novel approach to lowering the risk or improving function in ischemia-reperfusion brain injury-related disorders...
  21. ncbi Baicalein induction of hydroxyl radical formation via 12-lipoxygenase in human platelets: an ESR study
    Duen Suey Chou
    Graduate Institutes of Pharmacology and Medical Sciences, Taipei Medical University, No 250 Wu Hsing Street, Taipei 110, Taiwan
    J Agric Food Chem 55:649-55. 2007
    ..The results of this study led to the proposal that baicalein induces hydroxyl radical formation via 12-lipoxygenase and induces semiquinone radical formation via PGHS-peroxidase in human platelets...
  22. ncbi Decline in titin content in rat skeletal muscle after denervation
    Sy Ping Chen
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan
    Muscle Nerve 32:798-807. 2005
    ..Our study provides evidence that titin is more sensitive to degradation than MHC and actin after denervation. Moreover, the titin decline results in the loss of titin-based sarcomeric integrity in atrophic muscle...
  23. doi Inhibition of vascular smooth muscle cell proliferation by the vitamin E derivative pentamethylhydroxychromane in an in vitro and in vivo study: pivotal role of hydroxyl radical-mediated PLCgamma1 and JAK2 phosphorylation
    Cheng Ying Hsieh
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei 110, Taiwan
    Free Radic Biol Med 49:881-93. 2010
    ..PMC treatment may represent a novel approach for lowering the risk of or improving function in abnormal VSMC proliferation-related vascular diseases...
  24. doi Amyloid beta peptide-activated signal pathways in human platelets
    Ming Y Shen
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
    Eur J Pharmacol 588:259-66. 2008
    ..Further studies are needed to define the specific role of amyloid-beta activation of platelets in the pathogenesis of vasculopathy including cerebral amyloid angiopathy...
  25. doi Mechanisms of resveratrol-induced platelet apoptosis
    Kuan H Lin
    Graduate Institute of Medical Sciences, Taipei Medical University, 250 Wu Hsing Street, Taipei 110, Taiwan
    Cardiovasc Res 83:575-85. 2009
    ..In the present study, we demonstrate that resveratrol also markedly stimulates apoptosis in washed human platelets...
  26. doi Pycnidione, a fungus-derived agent, induces cell cycle arrest and apoptosis in A549 human lung cancer cells
    Che Jen Hsiao
    School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan
    Chem Biol Interact 197:23-30. 2012
    ..Therefore, testing of its effects in vivo is warranted to evaluate its potential as a therapeutic agent against lung cancer...
  27. ncbi Low concentration of oxidized low density lipoprotein suppresses platelet reactivity in vitro: an intracellular study
    Duen Suey Chou
    Graduate Institutes of Medical Sciences and Pharmacology, Taipei Medical University, Taipei 110, Taiwan
    Lipids 39:433-40. 2004
    ..This study provides new insights concerning the effect of oxLDL in platelet aggregation...
  28. doi Dynasore, a dynamin inhibitor, induces PAI-1 expression in MeT-5A human pleural mesothelial cells
    Chi Li Chung
    Department of Chest Medicine, Taipei Medical University Hospital and School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan
    Am J Respir Cell Mol Biol 40:692-700. 2009
    ..Given the profibrotic effect of dynasore, further in vivo studies may be conducted to evaluate its potential as a pleurodesing agent...
  29. ncbi Tetramethylpyrazine suppresses HIF-1alpha, TNF-alpha, and activated caspase-3 expression in middle cerebral artery occlusion-induced brain ischemia in rats
    Yi Chang
    Department of Anesthesiology, Shin Kong Wu Ho Su Memorial Hospital, Taipei 110, Taiwan, China
    Acta Pharmacol Sin 28:327-33. 2007
    ..To examine the detailed mechanisms underlying the inhibitory effect of tetramethylpyrazine (TMPZ) in inflammatory and apoptotic responses induced by middle cerebral artery occlusion (MCAO) in rats...
  30. ncbi Inhibitory mechanisms of tetramethylpyrazine in middle cerebral artery occlusion (MCAO)-induced focal cerebral ischemia in rats
    George Hsiao
    Graduate Institute of Pharmacology, Taipei Medical University, Taiwan, Republic of China
    Planta Med 72:411-7. 2006
    ..Thus, TMPZ treatment may represent an ideal approach to lowering the risk of or improving function in ischemia-reperfusion brain injury-related disorders...
  31. doi Neuroprotective effects of xanthohumol, a prenylated flavonoid from hops (Humulus lupulus), in ischemic stroke of rats
    Ting Lin Yen
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan
    J Agric Food Chem 60:1937-44. 2012
    ..Therefore, this novel role of xanthohumol may represent high therapeutic potential for treatment or prevention of ischemia-reperfusion injury-related disorders...
  32. doi Nuclear-targeted inhibition of NF-kappaB on MMP-9 production by N-2-(4-bromophenyl) ethyl caffeamide in human monocytic cells
    Yung Chen Chou
    Graduate Institute of Medical Sciences and Department of Pharmacology, Taipei Medical University, 250 Wu Hsing Street, Taipei 110 31, Taiwan
    Chem Biol Interact 184:403-12. 2010
    ..Further studies are needed to verify its anti-inflammatory effects...
  33. doi Hypertonicity-enhanced TNF-α release from activated human monocytic THP-1 cells requires ERK activation
    Yung Chen Chou
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan corrected
    Biochim Biophys Acta 1810:475-84. 2011
    ..As hypertonicity inhibits endocytosis, we evaluated the mechanism of hypertonicity-induced TNF-α release from activated human monocytic THP-1 cells...
  34. ncbi ESR spin trapping of a carbon-centered free radical from agonist-stimulated human platelets
    Duen Suey Chou
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei 110, Taiwan
    Free Radic Biol Med 39:237-48. 2005
    ..005 radical but could not restore platelet aggregatory activity. These results suggest that the carbon-centered radical is a self-destructing free radical formed during peroxide-mediated deactivation of PGHS in human platelets...
  35. doi Baicalein induces proliferation inhibition in B16F10 melanoma cells by generating reactive oxygen species via 12-lipoxygenase
    Duen Suey Chou
    Department of Pharmacology, Taipei Medical University, Taipei, Taiwan
    Free Radic Biol Med 46:1197-203. 2009
    ..On the basis of these data, we conclude that ROS formation catalyzed by 12-LOX is one possible mechanism of growth inhibition by baicalein in B16F10 melanoma cells...
  36. pmc Andrographolide enhances nuclear factor-kappaB subunit p65 Ser536 dephosphorylation through activation of protein phosphatase 2A in vascular smooth muscle cells
    Cheng Y Hsieh
    Graduate Institute of Medical Sciences, Department of Pharmacology, Taipei Medical University, Taipei 11031, Taiwan
    J Biol Chem 286:5942-55. 2011
    ....
  37. ncbi Detection of myofibrillar proteins using a step gradient minigel with an ambiguous interface
    Sy Ping Chen
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan
    Anal Biochem 338:270-7. 2005
    ..This gel system is simple to prepare and easy to use, and it is a reliable method for analyzing myofibrillar proteins or other protein mixtures with broad molecular masses...
  38. ncbi Inhibitory mechanisms of metallothionein on platelet aggregation in in vitro and platelet plug formation in in vivo experiments
    Joen R Sheu
    Department of Pharmacology, Graduate Institute of Medical Sciences, Taipei Medical University, Taipei 110, Taiwan
    Exp Biol Med (Maywood) 228:1321-8. 2003
    ..The results strongly indicate that metallothionein provides protection against thromboembolism...
  39. ncbi Mechanisms involved in agonist-induced hyperaggregability of platelets from normal pregnancy
    Joen Rong Sheu
    Graduate Institute of Medical Sciences, Department of Pharmacology, Taipei Medical University, Taipei, Taiwan, ROC
    J Biomed Sci 9:17-25. 2002
    ....
  40. ncbi Morphine-potentiated agonist-induced platelet aggregation through alpha2-adrenoceptors in human platelets
    Joen Rong Sheu
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan
    J Cardiovasc Pharmacol 40:743-50. 2002
    ....
  41. ncbi Mechanisms involved in the antiplatelet activity of magnesium in human platelets
    Joen Rong Sheu
    Graduate Institute of Medical Sciences and Department of Pharmacology, Taipei Medical University, Taipei, Taiwan
    Br J Haematol 119:1033-41. 2002
    ..2) Magnesium sulphate might also trigger the formation of cyclic AM, ultimately resulting in inhibition of the phosphorylation of P47 and intracellular Ca+2 mobilization...
  42. ncbi Mechanisms involved in the antiplatelet activity of midazolam in human platelets
    Joen R Sheu
    Graduate Institute of Medical Sciences and Department of Pharmacology, Taipei Medical University, Taipei, Taiwan
    Anesthesiology 96:651-8. 2002
    ..Midazolam is widely used as a sedative and anesthetic induction agent. The aim of this study was to systematically examine the inhibitory mechanisms of midazolam in platelet aggregation...
  43. ncbi Lipoteichoic acid-induced cyclooxygenase-2 expression requires activations of p44/42 and p38 mitogen-activated protein kinase signal pathways
    Chien Huang Lin
    Graduate Institute of Biomedical Technology, Taipei Medical University, Taipei, Taiwan, ROC
    Eur J Pharmacol 450:1-9. 2002
    ..Both events required activation of upstream tyrosine kinase and PKC...
  44. ncbi Antithrombotic effects of magnesium sulfate in in vivo experiments
    Joen R Sheu
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan
    Int J Hematol 77:414-9. 2003
    ..In conclusion, these results suggest that magnesium sulfate has an effective antithrombotic activity in vivo, and treatment with magnesium sulfate may lower the risk of thromboembolic-related disorders...
  45. pmc Expression of matrix metalloproteinase-9 in human platelets: regulation of platelet activation in in vitro and in vivo studies
    Joen R Sheu
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei 110, Taiwan
    Br J Pharmacol 143:193-201. 2004
    ..These results strongly indicate that MMP-9 is a potent inhibitor of aggregation. It may play an important role as a negative feedback regulator during platelet activation...
  46. doi Regulated expressions of MMP-2, -9 by diterpenoids from Euphorbia formosana Hayata
    Chia Chun Yu
    Graduate Institute of Pharmacognosy, Taipei Medical University, 250 Wu Xin Street, Taipei 110, Taiwan
    Molecules 17:2082-90. 2012
    ..Further biological tests by gelatin zymographic analysis revealed that 3-5 significantly up-regulated the expressions and activation of MMP-2 and -9 in human fibrosarcoma cell line HT1080...
  47. ncbi A potent antioxidant, lycopene, affords neuroprotection against microglia activation and focal cerebral ischemia in rats
    George Hsiao
    Graduate Institute of Pharmacology, Taipei Medical University, Taipei, Taiwan
    In Vivo 18:351-6. 2004
    ..Lycopene, through its antioxidative property, mediates at least a portion of free radical-scavenging activity and inhibits microglia activation, resulting in a reduction in infarct volume in ischemia/reperfusion brain injury...
  48. doi Estrogen deficiency-induced alterations of vascular MMP-2, MT1-MMP, and TIMP-2 in ovariectomized rats
    Kwok Keung Lam
    Department of Pharmacology, Taipei Medical University, Taipei, Taiwan
    Am J Hypertens 22:27-34. 2009
    ....
  49. ncbi Mechanisms involved in the antiplatelet activity of rutin, a glycoside of the flavonol quercetin, in human platelets
    Joen Rong Sheu
    Graduate Institutes of Medical Sciences and Pharmacology, Taipei Medical University, No 250 Wu Hsing Street, Taipei 110, Taiwan
    J Agric Food Chem 52:4414-8. 2004
    ....