Chin Wen Chi

Summary

Affiliation: Taipei Veterans General Hospital
Country: Taiwan

Publications

  1. pmc Reduced circulating endothelial progenitor cells in reversible cerebral vasoconstriction syndrome
    Shih Pin Chen
    Faculty of Medicine, School of Medicine, National Yang Ming University, Taipei, Taiwan
    J Headache Pain 15:82. 2014
  2. pmc Alteration of the copy number and deletion of mitochondrial DNA in human hepatocellular carcinoma
    P H Yin
    Institute of Pharmacology, National Yang Ming University, Taiwan, Republic of China
    Br J Cancer 90:2390-6. 2004
  3. pmc Reversal of Taxol resistance in hepatoma by cyclosporin A: involvement of the PI-3 kinase-AKT 1 pathway
    H L Lin
    Institute of Pharmacology, National Yang Ming University, Taipei, Taiwan
    Br J Cancer 88:973-80. 2003
  4. pmc Curcumin induces the apoptosis of human monocytic leukemia THP-1 cells via the activation of JNK/ERK pathways
    Chu Wen Yang
    Department of Microbiology, Soochow University, Shih Lin, Taipei 111, Taiwan, ROC
    BMC Complement Altern Med 12:22. 2012
  5. ncbi request reprint The antitumor effect of a novel differentiation inducer, 2, 2-Bis (4-(4-amino-3-hydroxyphenoxy) phenyl) adamantane (DPA), in combinatory therapy on human colon cancer
    Jane Jen Wang
    National Taipei College of Nursing, Taipei, Taiwan
    Int J Oncol 28:1003-12. 2006
  6. ncbi request reprint The anti-inflammatory potential of berberine in vitro and in vivo
    Chi Li Kuo
    Institute of Pharmacology, National Yang Ming University, Taipei, Taiwan, ROC
    Cancer Lett 203:127-37. 2004
  7. ncbi request reprint Anticancer effects of low-dose 10-hydroxycamptothecin in human colon cancer
    Yueh Hsin Ping
    Department and Institute of Pharmacology, School of Medicine, National Yang Ming University, Taipei 112, Taiwan
    Oncol Rep 15:1273-9. 2006
  8. doi request reprint Somatic mutations in mitochondrial genome and their potential roles in the progression of human gastric cancer
    Wen Yi Hung
    Department and Institute of Pharmacology, School of Medicine, National Yang Ming University, Taipei, Taiwan 112, ROC
    Biochim Biophys Acta 1800:264-70. 2010
  9. ncbi request reprint Enhanced oxidative stress and aberrant mitochondrial biogenesis in human neuroblastoma SH-SY5Y cells during methamphetamine induced apoptosis
    Chi Wei Wu
    Department and Institute of Pharmacology, School of Medicine, National Yang Ming University, Taipei, Taiwan 112, ROC
    Toxicol Appl Pharmacol 220:243-51. 2007
  10. ncbi request reprint Gene expression profiling predicts liver responses to a herbal remedy after partial hepatectomy in mice
    Jir You Wang
    Institute of Traditional Medicine, School of Medicine, National Yang Ming University, 155, Sec 2, Li Nong Street, Peitou, Taipei, 112 Taiwan, R O C
    Int J Mol Med 16:221-31. 2005

Collaborators

Detail Information

Publications67

  1. pmc Reduced circulating endothelial progenitor cells in reversible cerebral vasoconstriction syndrome
    Shih Pin Chen
    Faculty of Medicine, School of Medicine, National Yang Ming University, Taipei, Taiwan
    J Headache Pain 15:82. 2014
    ..This study aimed to explore whether patients with RCVS have a reduced level of circulating circulating endothelial progenitor cells (EPCs) to repair the dysfunctional endothelial vasomotor control...
  2. pmc Alteration of the copy number and deletion of mitochondrial DNA in human hepatocellular carcinoma
    P H Yin
    Institute of Pharmacology, National Yang Ming University, Taiwan, Republic of China
    Br J Cancer 90:2390-6. 2004
    ....
  3. pmc Reversal of Taxol resistance in hepatoma by cyclosporin A: involvement of the PI-3 kinase-AKT 1 pathway
    H L Lin
    Institute of Pharmacology, National Yang Ming University, Taipei, Taiwan
    Br J Cancer 88:973-80. 2003
    ..Our results indicate that the combination of cyclosporin A and Taxol is effective in the reversal of Taxol resistance through the inhibition of PI3 kinase-AKT1 pathway...
  4. pmc Curcumin induces the apoptosis of human monocytic leukemia THP-1 cells via the activation of JNK/ERK pathways
    Chu Wen Yang
    Department of Microbiology, Soochow University, Shih Lin, Taipei 111, Taiwan, ROC
    BMC Complement Altern Med 12:22. 2012
    ..However, its anti-cancer activity in human acute monocytic leukemia THP-1 cells is not clear. This study aimed to study the anti-cancer effect and action of curcumin on THP-1 cells...
  5. ncbi request reprint The antitumor effect of a novel differentiation inducer, 2, 2-Bis (4-(4-amino-3-hydroxyphenoxy) phenyl) adamantane (DPA), in combinatory therapy on human colon cancer
    Jane Jen Wang
    National Taipei College of Nursing, Taipei, Taiwan
    Int J Oncol 28:1003-12. 2006
    ..Our results suggest that DPA appears to be a new potentially less toxic modality of cancer combinatory therapy...
  6. ncbi request reprint The anti-inflammatory potential of berberine in vitro and in vivo
    Chi Li Kuo
    Institute of Pharmacology, National Yang Ming University, Taipei, Taiwan, ROC
    Cancer Lett 203:127-37. 2004
    ..These anti-inflammatory effects paralleled to the in vivo results where berberine pretreatment of Wistar rat inhibited the production of exudates and PGE2 in carrageenan induced air pouch...
  7. ncbi request reprint Anticancer effects of low-dose 10-hydroxycamptothecin in human colon cancer
    Yueh Hsin Ping
    Department and Institute of Pharmacology, School of Medicine, National Yang Ming University, Taipei 112, Taiwan
    Oncol Rep 15:1273-9. 2006
    ..The results of this study suggest that a relatively low dose of 10-HCPT (p.o.) is able to inhibit the growth of colon cancer, facilitating the development of a new protocol of human trials with this anticancer drug...
  8. doi request reprint Somatic mutations in mitochondrial genome and their potential roles in the progression of human gastric cancer
    Wen Yi Hung
    Department and Institute of Pharmacology, School of Medicine, National Yang Ming University, Taipei, Taiwan 112, ROC
    Biochim Biophys Acta 1800:264-70. 2010
    ..In our previous study, high frequency of somatic mutations was found in the D-loop region of mtDNA of gastric cancers. However, it is unclear whether somatic mutations occur in the coding region of mtDNA of gastric cancers...
  9. ncbi request reprint Enhanced oxidative stress and aberrant mitochondrial biogenesis in human neuroblastoma SH-SY5Y cells during methamphetamine induced apoptosis
    Chi Wei Wu
    Department and Institute of Pharmacology, School of Medicine, National Yang Ming University, Taipei, Taiwan 112, ROC
    Toxicol Appl Pharmacol 220:243-51. 2007
    ..Our observations suggest that enhanced oxidative stress and aberrant mitochondrial biogenesis may play critical roles in METH-induced neurotoxic effects...
  10. ncbi request reprint Gene expression profiling predicts liver responses to a herbal remedy after partial hepatectomy in mice
    Jir You Wang
    Institute of Traditional Medicine, School of Medicine, National Yang Ming University, 155, Sec 2, Li Nong Street, Peitou, Taipei, 112 Taiwan, R O C
    Int J Mol Med 16:221-31. 2005
    ..We conclude that in vivo gene expression profiling correlates with liver responses to a herbal remedy, which provides a new direction for pharmaceutical studies on human diseases...
  11. doi request reprint Mitochondrial dysfunction promotes cell migration via reactive oxygen species-enhanced β5-integrin expression in human gastric cancer SC-M1 cells
    Wen Yi Hung
    Department and Institute of Pharmacology, School of Medicine, National Yang Ming University, and Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan
    Biochim Biophys Acta 1820:1102-10. 2012
    ..Mitochondrial dysfunction has been shown to promote cancer cell migration. However, molecular mechanism by which mitochondrial dysfunction enhances gastric cancer (GC) cell migration remains unclear...
  12. ncbi request reprint Hydroxychavicol modulates benzo[a]pyrene-induced genotoxicity through induction of dihydrodiol dehydrogenase
    Deh Wei Tang
    Institutes of Pharmacology, National Yang Ming University, Taipei, Taiwan, ROC
    Toxicol Lett 152:235-43. 2004
    ..Furthermore, DDH-mediated oxidative DNA damage and not B[a]P-DNA adduct formation may be involved in the HC and B[a]P-induced toxic effects...
  13. ncbi request reprint Mitochondrial DNA mutations and mitochondrial DNA depletion in gastric cancer
    Chew Wun Wu
    Department of Surgery, Taipei Veterans General Hospital, Taiwan, Republic of China
    Genes Chromosomes Cancer 44:19-28. 2005
    ..018). Our results suggest that somatic mtDNA mutations and mtDNA depletion occur in gastric cancer and that mtDNA depletion is involved in carcinogenesis and/or cancer progression of gastric carcinoma...
  14. doi request reprint Quercetin induces oxidative stress and potentiates the apoptotic action of 2-methoxyestradiol in human hepatoma cells
    Yuh Fang Chang
    Taipei Veterans General Hospital, Taipei, Taiwan
    Nutr Cancer 61:735-45. 2009
    ..These results provided a basis for further study of the potential usage of quercetin combination with hormonal agents for the treatment of human hepatoma...
  15. ncbi request reprint Effects of Scutellaria baicalensis Georgi on macrophage-hepatocyte interaction through cytokines related to growth control of murine hepatocytes
    Jir You Wang
    Institute of Traditional Medicine, School of Medicine, National Yang Ming University, Taipei, 112 Taiwan, R O C
    Exp Biol Med (Maywood) 231:444-55. 2006
    ....
  16. ncbi request reprint Polymorphisms of estrogen-metabolizing genes and risk of hepatocellular carcinoma in Taiwan females
    Pen Hui Yin
    Institute of Pharmacology, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Cancer Lett 212:195-201. 2004
    ..63 (1.50, 106.37), and the OR for three putative high-risk genotypes was 16.67 (1.82, 152.77). These findings strongly suggest that estrogen play a critical role in female hepatocarcinogenesis...
  17. ncbi request reprint Mitochondrial DNA mutations and mitochondrial DNA depletion in breast cancer
    Ling Ming Tseng
    Department of Surgery, Taipei Veterans General Hospital, and National Yang Ming University, Taiwan, Republic of China
    Genes Chromosomes Cancer 45:629-38. 2006
    ..Our findings suggest that somatic mutations in mtDNA D-loop can be used as a new molecular prognostic indicator in breast cancer...
  18. ncbi request reprint Elevated expression of cyclooxygenase (COX)-2 in oral squamous cell carcinoma--evidence for COX-2 induction by areca quid ingredients in oral keratinocytes
    Deh Wei Tang
    Institute of Pharmacology, National Yang Ming University, Taipei, Taiwan
    J Oral Pathol Med 32:522-9. 2003
    ..Whether COX-2 is up-regulated in areca quid (AQ) related oral squamous cell carcinoma (OSCC) is unknown and the potential of AQ ingredients to induce COX-2 expression has not been studied...
  19. ncbi request reprint The predictive ability of serum alpha-fetoprotein for hepatocellular carcinoma is linked with the characteristics of the target population at surveillance
    Teh Ia Huo
    Institute of Pharmacology, National Yang Ming University School of Medicine, Taipei, Taiwan
    J Surg Oncol 95:645-51. 2007
    ..The reported predictive accuracy of AFP for HCC widely varied. This study investigated the factors contributory to the heterogeneity of the ability of AFP to detect HCC...
  20. doi request reprint Leptin enhances migration of human papillary thyroid cancer cells through the PI3K/AKT and MEK/ERK signaling pathways
    Shih Ping Cheng
    Department of Surgery, Mackay Memorial Hospital, Taipei, Taiwan, ROC
    Oncol Rep 26:1265-71. 2011
    ..Taken together, this study provides new mechanistic evidence for a role of leptin in the regulation of papillary thyroid cancer progression by stimulating tumor cell migration...
  21. ncbi request reprint PGC-1α mediates differentiation of mesenchymal stem cells to brown adipose cells
    Pin I Huang
    Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan
    J Atheroscler Thromb 18:966-80. 2011
    ..Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) controls several aspects of mitochondrial biogenesis. In this study, we hypothesized that PGC-1α plays a role in brown fat differentiation of MSCs...
  22. pmc CD133-expressing thyroid cancer cells are undifferentiated, radioresistant and survive radioiodide therapy
    Chien Chih Ke
    Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan
    Eur J Nucl Med Mol Imaging 40:61-71. 2013
    ..The aim of this study was to investigate whether CD133(+) cells contribute to the radioresistance of thyroid cancer and thus potentiate future recurrence and metastasis...
  23. doi request reprint Norcantharidin suppresses cell growth and migration with enhanced anticancer activity of gefitinib and cisplatin in human non-small cell lung cancer cells
    Ya Chun Lee
    Department and Institute of Pharmacology, School of Medicine, National Yang Ming University, Taipei, Taiwan, ROC
    Oncol Rep 29:237-43. 2013
    ....
  24. ncbi request reprint Combretastatin A4-induced differential cytotoxicity and reduced metastatic ability by inhibition of AKT function in human gastric cancer cells
    Heng Liang Lin
    Institute of Pharmacology, National Yang Ming University, Taipei, Taiwan
    J Pharmacol Exp Ther 323:365-73. 2007
    ..Further investigation on drugs targeting the PI3 kinase-AKT pathway may provide a new approach for the treatment of human gastric cancer...
  25. ncbi request reprint The HIV RNA Levels of Plasma and Ocular Fluids in AIDS Patients with Ophthalmic Infections
    Wen Ming Hsu
    Department of Ophthalmology, Taipei Veterans General Hospital and National Yang Ming University and Institutes of Clinical Medicine, Taipei, Taiwan, ROC
    Ophthalmologica 218:328-32. 2004
    ..HIV virus levels in the plasma of AIDS patients were significantly decreased, and the CD4 counts of these patients were significantly increased (Wilcoxon test) after initiation of HAART...
  26. ncbi request reprint Modulation of apoptosis by berberine through inhibition of cyclooxygenase-2 and Mcl-1 expression in oral cancer cells
    Chi Li Kuo
    Institute of Pharmacology, National Yang Ming University, Taipei, Taiwan, Republic of China
    In Vivo 19:247-52. 2005
    ..We have previously shown that berberine exerts its anti-inflammatory effects through inhibition of cyclooxygenase-2 (COX-2) expression. In this study, we explored the biochemical influence of berberine-induced COX-2 reduction and apoptosis...
  27. doi request reprint Rab5A is associated with axillary lymph node metastasis in breast cancer patients
    Po Sheng Yang
    Institute of Pharmacology, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Cancer Sci 102:2172-8. 2011
    ..043). Among 218 axillary LNs of more than 10 breast cancer patients with node metastases, 167 metastatic LNs were found to have increased Rab5A expression. Rab5A is associated with axillary LN metastasis in breast cancer patients...
  28. ncbi request reprint Differential roles of leptin in regulating cell migration in thyroid cancer cells
    Shih Ping Cheng
    Department and Institute of Pharmacology, School of Medicine, National Yang Ming University, Taipei, Taiwan, ROC
    Oncol Rep 23:1721-7. 2010
    ..In summary, our study suggests that leptin modulates cell migration of thyroid cancer cells in a cell type-specific manner...
  29. doi request reprint Role of p21 as a determinant of 1,6-Bis[4-(4-amino-3-hydroxyphenoxy)phenyl] diamantane response in human HCT-116 colon carcinoma cells
    Jane Jen Wang
    Center of General Education, National Taipei University of Nursing and Health Sciences, and Department of Medical Research and Educaiton, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    Oncol Rep 27:529-34. 2012
    ..Our results clearly demonstrate that DPD-induced in vitro and in vivo anticancer effects through the activation of p21 in HCT-116 cells...
  30. ncbi request reprint Increase in mitochondrial mass in human fibroblasts under oxidative stress and during replicative cell senescence
    Hsin Chen Lee
    Department of Biochemistry and Center for Cellular and Molecular Biology, National Yang Ming University, Taipei, Taiwan, ROC
    J Biomed Sci 9:517-26. 2002
    ....
  31. doi request reprint SOCS6, down-regulated in gastric cancer, inhibits cell proliferation and colony formation
    Rai Hua Lai
    Institute of Pharmacology, National Yang Ming University, Taiwan, ROC
    Cancer Lett 288:75-85. 2010
    ..Taken together, this study provides molecular and functional data supporting the importance of loss-of-function of SOCS6 as a frequent event in gastric tumorigenesis...
  32. doi request reprint Advanced gastric cancer patients with lymphoid stroma have better survival than those without
    Kuo Hung Huang
    Division of General Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan
    J Surg Oncol 107:523-8. 2013
    ..Lymphoid stroma is a specific pathologic appearance in gastric cancer. This study aims to compare the clinicopathological characteristics of gastric cancer patients with and without lymphoid stroma...
  33. ncbi request reprint Safrole-DNA adducts in human peripheral blood--an association with areca quid chewing and CYP2E1 polymorphisms
    Tsung Yun Liu
    Institute of Pharmacology, National Yang Ming University, Taipei, Taiwan, ROC
    Mutat Res 559:59-66. 2004
    ..In addition, the CYP2E1 would seem to play an important role in the modulation of safrole-DNA adduct formation...
  34. pmc Investigation of a potential scintigraphic tracer for imaging apoptosis: radioiodinated annexin V-Kunitz protease inhibitor fusion protein
    Mei Hsiu Liao
    Institute of Pharmacology, School of Medicine, National Yang Ming University, Taipei 112, Taiwan
    J Biomed Biotechnol 2011:675701. 2011
    ..High uptake in the liver and the kidneys may limit the evaluation of apoptosis in abdominal regions. Our data suggest that radiolabeled ANV-6L15 may be a better scintigraphic tracer than native ANV for apoptosis detection...
  35. doi request reprint The oxidative metabolism of dimemorfan by human cytochrome P450 enzymes
    Yueh Ching Chou
    Pharmacy Department, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    J Pharm Sci 99:1063-77. 2010
    ..02 mM in forming M1. CYP2B6, CYP2C9, and CYP2C19 had the K(m) or S(50) values smaller than those (1 mM) of CYP2D6 and CYP3A4 in forming M2. These results indicated the participation of multiple P450 forms in DFO...
  36. ncbi request reprint 2-Methoxyestradiol attenuates phosphatidylinositol 3-kinase/Akt pathway-mediated metastasis of gastric cancer
    Heng Liang Lin
    Department of Medical Research and Education, Taipei Veterans General Hospital, National Yang Ming University, Taipei, Taiwan
    Int J Cancer 121:2547-55. 2007
    ..We conclude that the activation of PI3K/Akt pathway is involved in the late-stage progression and metastasis of gastric cancer, and attenuation of p-Akt by 2-ME suppresses metastasis...
  37. doi request reprint Mitochondrial dysfunction represses HIF-1α protein synthesis through AMPK activation in human hepatoma HepG2 cells
    Chia Chi Hsu
    Department and Institute of Pharmacology, National Yang Ming University, Taiwan
    Biochim Biophys Acta 1830:4743-51. 2013
    ..However, the effects and mechanisms of mitochondrial dysfunction on HIF-1α function are not fully understood. This study aims to explore the underlying mechanism by which mitochondrial dysfunction regulates HIF-1α expression...
  38. doi request reprint Somatic mutations of the mitochondrial genome in human breast cancers
    Ling Ming Tseng
    Department of Surgery, Taipei Veterans General Hospital, and National Yang Ming University, Taipei, Taiwan
    Genes Chromosomes Cancer 50:800-11. 2011
    ..In conclusion, our results suggest that somatic mtDNA mutations may play a critical role in the progression of breast cancer...
  39. ncbi request reprint Effects of pH on nicotine-induced DNA damage and oxidative stress
    Hui Ju Wu
    Institute of Pharmacology, School of Medicine, National Yang Ming University, Taipei, Taiwan, Republic of China
    J Toxicol Environ Health A 68:1511-23. 2005
    ..Thus, alkaline saliva generated by chewing betel quid plays an important role in cigarette-related nicotine-induced DNA damage, and reactive oxygen species may be involved in generating this DNA damage...
  40. doi request reprint Notch2-induced COX-2 expression enhancing gastric cancer progression
    Yun Chien Tseng
    Department of Anatomy and Cell Biology, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Mol Carcinog 51:939-51. 2012
    ..Taken together, this study is the first to demonstrate that the Notch2-COX-2 signaling axis plays an important role in controlling gastric cancer progression...
  41. ncbi request reprint Mitochondrial genome instability and mtDNA depletion in human cancers
    Hsin Chen Lee
    Department of Pharmacology, School of Medicine, National Yang Ming University, Taipei, Taiwan 112, Republic of China
    Ann N Y Acad Sci 1042:109-22. 2005
    ..Taken together, our findings suggest that instability in the D-loop region of mtDNA, together with the decrease in mtDNA copy number, is involved in the carcinogenesis of human cancers...
  42. ncbi request reprint In vivo and in vitro growth stimulation of murine hepatoma cells by glucocorticoid
    Wing Yiu Lui
    Department of Surgery, Veterans General Hospital Taipei, Taiwan, Republic of China
    Anticancer Res 22:1413-22. 2002
    ..In conclusion, our results indicated that glucocorticoid directly stimulated hepatoma growth and this stimulation was not the result of immune suppression. Glucocorticoids may play an important role in regulating the growth of hepatoma...
  43. ncbi request reprint Survival impact of delayed treatment in patients with hepatocellular carcinoma undergoing locoregional therapy: is there a lead-time bias?
    Teh Ia Huo
    Institute of Pharmacology, National Yang Ming University School of Medicine, Taipei, Taiwan
    Scand J Gastroenterol 42:485-92. 2007
    ..The objective of this study was to investigate whether patients with delayed locoregional therapy for HCC truly have a shortened survival from the time of diagnosis...
  44. doi request reprint SIRT3 expression as a biomarker for better prognosis in gastric cancer
    Kuo Hung Huang
    Division of General Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan
    World J Surg 38:910-7. 2014
    ..SIRT3-mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase sirtuin-3-plays an important role in regulating cell metabolism and carcinogenesis. The role of SIRT3 in gastric cancer has not yet been investigated...
  45. ncbi request reprint Mitochondria are an essential mediator of nitric oxide/cyclic guanosine 3',5'-monophosphate blocking of glucose depletion induced cytotoxicity in human HepG2 cells
    Yi Chiung Hsu
    Institute of Pharmacology, School of Medicine, National Yang Ming University, and Department of Medical Research and Education, Taipei Veterans General Hospital, Taiwan
    Mol Cancer Res 5:923-32. 2007
    ..Taken together, our results indicated that the mitochondria serve as an important cellular mediator of NO during protection against glucose deprivation-induced damage...
  46. ncbi request reprint Analysis of silibinin in rat plasma and bile for hepatobiliary excretion and oral bioavailability application
    Jhy Wen Wu
    Institute of Traditional Medicine, School of Medicine, National Yang Ming University, Taipei 112, Taiwan
    J Pharm Biomed Anal 45:635-41. 2007
    ..The oral bioavailability of silibinin in rats was estimated to be 0.73%...
  47. ncbi request reprint Overexpression of rho effector rhotekin confers increased survival in gastric adenocarcinoma
    Ching Ann Liu
    Graduate Institute of Life Sciences, National Defense Medical Center, Veterans General Hospital, Taipei, Taiwan, ROC
    J Biomed Sci 11:661-70. 2004
    ..This study provides original documentation for the overrepresentation of the Rho GTPase effector rhotekin in human cancer and its links to cancer formation...
  48. pmc The reciprocal regulation loop of Notch2 pathway and miR-23b in controlling gastric carcinogenesis
    Tzu Ting Huang
    Department and Institute of Pharmacology, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Oncotarget 6:18012-26. 2015
    ..Our results suggest that Notch2 pathway and miR-23b interplay in a reciprocal regulation loop in gastric cancer cells and this axis plays an important role in gastric carcinogenesis...
  49. doi request reprint The role of estrogen in the survival of ovarian tumors--a study of the human ovarian adenocarcinoma cell lines OC-117-VGH and OVCAR3
    Kuan Chong Chao
    Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    J Chin Med Assoc 76:63-70. 2013
    ..In this study, we investigated the changes in cell-cycle regulatory proteins in ovarian cancer cell lines after estrogen treatment to explore the role of estrogen in ovarian cancers...
  50. ncbi request reprint Clinical significance of AXL kinase family in gastric cancer
    Chew Wun Wu
    Departments of Surgery, Taipei Veterans General Hospital and School of Medicine, National Yang Ming University, Taiwan
    Anticancer Res 22:1071-8. 2002
    ..In previous studies, we have shown the clinical significance of two tyrosine kinases identified in gastric cancer, tie-1 and mkk4...
  51. doi request reprint Heteroplasmy of mitochondrial D310 mononucleotide repeat region in the blood of patients with Alzheimer's disease
    Pei ning Wang
    Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan
    J Alzheimers Dis 18:345-53. 2009
    ..The results suggest that mutations of mtDNA 310 region are frequently present in the peripheral blood of AD patients. Further prospective investigations to determine if MCI subjects with D310 mutations develop AD is warranted...
  52. ncbi request reprint Protein tyrosine-phosphatase expression profiling in gastric cancer tissues
    Chew Wun Wu
    Department of Surgery, Veterans General Hospital, Taipei, Taiwan, ROC
    Cancer Lett 242:95-103. 2006
    ....
  53. ncbi request reprint The model for end-stage liver disease based cancer staging systems are better prognostic models for hepatocellular carcinoma: a prospective sequential survey
    Teh Ia Huo
    Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Am J Gastroenterol 102:1920-30. 2007
    ....
  54. ncbi request reprint Hydroxyl radical formation and oxidative DNA damage induced by areca quid in vivo
    Chiu Lan Chen
    Department of Pharmacy, Chia Nan University of Pharmacy and Science, Tainan Hsien, Taiwan, Republic of China
    J Toxicol Environ Health A 65:327-36. 2002
    ..These findings demonstrate that ROS, such as hydroxyl radical, are formed in the human oral cavity during AQ chewing, and chewing such prepared AQ might cause oxidative DNA damage to the surrounding tissues...
  55. ncbi request reprint Heteroplasmic mutation of mitochondrial DNA D-loop and 4977-bp deletion in human cancer cells during mitochondrial DNA depletion
    Hsin Chen Lee
    Department and Institute of Pharmacology, School of Medicine, National Yang Ming University, Taipei, Taiwan 112, Republic of China
    Mitochondrion 7:157-63. 2007
    ..Mitochondrial genome instability and reduced mtDNA copy number may independently occur in human cancer...
  56. pmc MBP-1 suppresses growth and metastasis of gastric cancer cells through COX-2
    Kai Wen Hsu
    Department of Anatomy and Cell Biology, National Yang Ming University, Taipei, Taiwan
    Mol Biol Cell 20:5127-37. 2009
    ..Taken together, these results suggest that MBP-1-suppressed COX-2 expression plays an important role in the inhibition of growth and progression of gastric cancer...
  57. doi request reprint Anti-proliferative effects of evodiamine on human thyroid cancer cell line ARO
    Meng Ching Chen
    Department of Physiology, School of Medicine, National Yang Ming University, Taipei City 11221, Taiwan, Republic of China
    J Cell Biochem 110:1495-503. 2010
    ..These results suggested that evodiamine inhibited the growth of the ARO cells, arrested them at M phase, and induced apoptosis through caspases signaling...
  58. ncbi request reprint Baicalein attenuates methamphetamine-induced loss of dopamine transporter in mouse striatum
    Ping Ho Wu
    Institute of Pharmacology, School of Medicine, National Yang Ming University, Taipei 112, Taiwan, ROC
    Toxicology 226:238-45. 2006
    ..These results suggested that baicalein may attenuate methamphetamine-induced DAT loss by inhibiting the neutrophil increase and the lipid peroxidation caused by neutrophil-derived reactive oxygen species in striatum...
  59. pmc Notch1 pathway-mediated microRNA-151-5p promotes gastric cancer progression
    Kai Wen Hsu
    Institute of Anatomy and Cell Biology, School of Medicine, National Yang Ming University, Taipei 112, Taiwan
    Oncotarget 7:38036-38051. 2016
    ..Taken together, these results suggest that Notch1 pathway and miR-151-5p interplay with p53 in a reciprocal regulation loop in controlling gastric carcinogenesis...
  60. ncbi request reprint Arg tyrosine kinase expression in human gastric adenocarcinoma is associated with vessel invasion
    Chew Wun Wu
    Department of Surgery, Veterans General Hospital, Taipei, Taiwan, Republic of China
    Anticancer Res 23:205-10. 2003
    ..In previous studies, we have shown the clinical significance of arg tyrosine kinases in a colorectal cancer progression model...
  61. ncbi request reprint Clinical implications of chromosomal abnormalities in gastric adenocarcinomas
    Chew Wun Wu
    Department of Surgery, Veterans General Hospital Taipei, Taipei, Taiwan
    Genes Chromosomes Cancer 35:219-31. 2002
    ..Metastatic tumors were also associated with specific genetic changes. These regions may harbor candidate genes involved in the pathogenesis of this malignancy...
  62. ncbi request reprint Effects of clodronate on cancer growth and Ca2+ signaling of human thyroid carcinoma cell lines
    De Ming Yang
    Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China
    Anticancer Res 24:1617-23. 2004
    ..The results from this study implied that clodronate-mediated cell growth inhibition in slow growing thyroid cancer cells might correlate with a Ca2+ signaling pathway...
  63. doi request reprint Effects of Areca catechu L. containing procyanidins on cyclooxygenase-2 expression in vitro and in vivo
    Pei Ling Huang
    Institute of Pharmacology, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Food Chem Toxicol 48:306-13. 2010
    ..In conclusion, ANE, which contains catechins based oligomeric and polymeric procyanidins, regulates COX-2 expression in vitro and possess anti-inflammatory potential in vivo...
  64. doi request reprint Targeting signal transducer and activator of transcription 3 pathway by cucurbitacin I diminishes self-renewing and radiochemoresistant abilities in thyroid cancer-derived CD133+ cells
    Ling Ming Tseng
    Institute of Clinical Medicine, School of Medicine, National Yang Ming University, Taipei, Taiwan
    J Pharmacol Exp Ther 341:410-23. 2012
    ..In summary, these results show that the STAT3 pathway plays a key role in mediating CSC properties in ATC-CD133+ cells. Targeting STAT3 with cucurbitacin I in ATC may provide a new approach for therapeutic treatment in the future...
  65. ncbi request reprint Identification of a novel cell cycle regulated gene, HURP, overexpressed in human hepatocellular carcinoma
    Ann Ping Tsou
    Institute of Biotechnology in Medicine, National Yang Ming University, Taipei, Taiwan
    Oncogene 22:298-307. 2003
    ..Taken together, these results strongly suggest that HURP is a potential novel cell cycle regulator that may play a role in the carcinogenesis of human cancer cells...
  66. pmc Targeting protective autophagy exacerbates UV-triggered apoptotic cell death
    Li Hsin Chen
    Institute of Pharmacology, School of Medicine, National Yang Ming University, Taipei 11221, Taiwan E Mails L H C C W C
    Int J Mol Sci 13:1209-24. 2012
    ..In conclusion, this study demonstrated that autophagy acts as a cytoprotective mechanism against UV-induced apoptosis and that autophagy induction accompanied with apoptosis at late stages is independent of ATR activation...
  67. doi request reprint Autophagy inhibition enhances apoptosis triggered by BO-1051, an N-mustard derivative, and involves the ATM signaling pathway
    Li Hsin Chen
    Department and Institute of Pharmacology, School of Medicine, National Yang Ming University, 155, Sec 2, Linong Street, Taipei 112, Taiwan
    Biochem Pharmacol 81:594-605. 2011
    ..Autophagy contributes to the remarkable drug resistance ability of liver cancer...