Henrich Cheng

Summary

Affiliation: Taipei Veterans General Hospital
Country: Taiwan

Publications

  1. pmc Cytoprotective and anti-inflammatory effects of PAL31 overexpression in glial cells
    Fan Wei Tseng
    Department and Institute of Pharmacology, School of Medicine, National Yang Ming University, Taipei, Taiwan
    J Biomed Sci 21:60. 2014
  2. pmc Vitamin D status in non-supplemented postmenopausal Taiwanese women with osteoporosis and fragility fracture
    Jawl Shan Hwang
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University, 123, Ta Pei Road, Niao Sung Hsiang, Kaohsiung, Taiwan
    BMC Musculoskelet Disord 15:257. 2014
  3. pmc Comparative effects of bone marrow mesenchymal stem cells on lipopolysaccharide-induced microglial activation
    Fan Wei Tseng
    Department and Institute of Pharmacology, School of Medicine, National Yang Ming University, Taipei 11221, Taiwan
    Oxid Med Cell Longev 2013:234179. 2013
  4. pmc Recovery of neurological function of ischemic stroke by application of conditioned medium of bone marrow mesenchymal stem cells derived from normal and cerebral ischemia rats
    May Jywan Tsai
    Neural Regeneration Laboratory, Center for Neural Regeneration, Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, NO, 322, Section 2, Shih Pai Road, Taipei City, Beitou District 112, Taiwan
    J Biomed Sci 21:5. 2014
  5. ncbi request reprint Ability of GDNF to diminish free radical production leads to protection against kainate-induced excitotoxicity in hippocampus
    Henrich Cheng
    Neural Regeneration Laboratory, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
    Hippocampus 14:77-86. 2004
  6. doi request reprint Functional recovery after the repair of transected cervical roots in the chronic stage of injury
    Ming Chao Huang
    Center for Neural Regeneration, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
    J Neurotrauma 26:1795-804. 2009
  7. doi request reprint Acid fibroblast growth factor and peripheral nerve grafts regulate Th2 cytokine expression, macrophage activation, polyamine synthesis, and neurotrophin expression in transected rat spinal cords
    Huai Sheng Kuo
    Neural Regeneration Laboratory and Center for Neural Regeneration, Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China
    J Neurosci 31:4137-47. 2011
  8. ncbi request reprint Sensory and motor recovery after repairing transected cervical roots
    Ming Chao Huang
    Department of Neurosurgery, Neural Regeneration Laboratory, Taipei Veterans General Hospital, Taipei 11217, Taiwan
    Surg Neurol 68:S17-24; discussion S24. 2007
  9. doi request reprint Treatment with nerve grafts and aFGF attenuates allodynia caused by cervical root transection injuries
    Yi Lo Lin
    Neural Regeneration Laboratory, Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
    Restor Neurol Neurosci 29:265-74. 2011
  10. doi request reprint Adeno-associated virus-mediated human acidic fibroblast growth factor expression promotes functional recovery of spinal cord-contused rats
    Wen Cheng Huang
    Centre for Neural Regeneration, Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
    J Gene Med 13:283-9. 2011

Collaborators

Detail Information

Publications97

  1. pmc Cytoprotective and anti-inflammatory effects of PAL31 overexpression in glial cells
    Fan Wei Tseng
    Department and Institute of Pharmacology, School of Medicine, National Yang Ming University, Taipei, Taiwan
    J Biomed Sci 21:60. 2014
    ..Because PAL31 participates in cell cycle progression and reactive astroglia often appears in the injured cord, we aim to examine whether PAL31 is involved in glial modulation after injury...
  2. pmc Vitamin D status in non-supplemented postmenopausal Taiwanese women with osteoporosis and fragility fracture
    Jawl Shan Hwang
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University, 123, Ta Pei Road, Niao Sung Hsiang, Kaohsiung, Taiwan
    BMC Musculoskelet Disord 15:257. 2014
    ..The aim of this study was to assess the prevalence of vitamin D inadequacy among non-supplemented postmenopausal women with osteoporosis and fragility fractures of the hip or vertebrae in Taiwan...
  3. pmc Comparative effects of bone marrow mesenchymal stem cells on lipopolysaccharide-induced microglial activation
    Fan Wei Tseng
    Department and Institute of Pharmacology, School of Medicine, National Yang Ming University, Taipei 11221, Taiwan
    Oxid Med Cell Longev 2013:234179. 2013
    ..The downregulated MMP-9 mRNA may be caused by TIMP-1 secretion from BMMSC. Our cell culture system provides a powerful tool for investigating the molecular and cellular changes in microglia-BMMSC cocultures...
  4. pmc Recovery of neurological function of ischemic stroke by application of conditioned medium of bone marrow mesenchymal stem cells derived from normal and cerebral ischemia rats
    May Jywan Tsai
    Neural Regeneration Laboratory, Center for Neural Regeneration, Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, NO, 322, Section 2, Shih Pai Road, Taipei City, Beitou District 112, Taiwan
    J Biomed Sci 21:5. 2014
    ..The present work aims to characterize BM-MSC prepared from normal healthy rats (NormBM-MSC) and cerebral ischemia rats (IschBM-MSC), and examine the effects of their conditioned medium (Cm) on ischemic stroke animal model...
  5. ncbi request reprint Ability of GDNF to diminish free radical production leads to protection against kainate-induced excitotoxicity in hippocampus
    Henrich Cheng
    Neural Regeneration Laboratory, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
    Hippocampus 14:77-86. 2004
    ..We suggest that mechanisms including a decrease in free radical generation and scavenging of free radicals might be involved in GDNF protection against kainate-induced excitotoxicity...
  6. doi request reprint Functional recovery after the repair of transected cervical roots in the chronic stage of injury
    Ming Chao Huang
    Center for Neural Regeneration, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
    J Neurotrauma 26:1795-804. 2009
    ....
  7. doi request reprint Acid fibroblast growth factor and peripheral nerve grafts regulate Th2 cytokine expression, macrophage activation, polyamine synthesis, and neurotrophin expression in transected rat spinal cords
    Huai Sheng Kuo
    Neural Regeneration Laboratory and Center for Neural Regeneration, Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China
    J Neurosci 31:4137-47. 2011
    ..These results indicate that aFGF and nerve grafts regulate different macrophage responses, and M2 macrophages may play an important role in axonal regeneration after spinal cord injury in rats...
  8. ncbi request reprint Sensory and motor recovery after repairing transected cervical roots
    Ming Chao Huang
    Department of Neurosurgery, Neural Regeneration Laboratory, Taipei Veterans General Hospital, Taipei 11217, Taiwan
    Surg Neurol 68:S17-24; discussion S24. 2007
    ....
  9. doi request reprint Treatment with nerve grafts and aFGF attenuates allodynia caused by cervical root transection injuries
    Yi Lo Lin
    Neural Regeneration Laboratory, Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
    Restor Neurol Neurosci 29:265-74. 2011
    ..Nerve root traction injuries induce spinal cord inflammation and lead to neuronal death within days. In the present study, we examined the inflammatory response one week after multiple cervical root transections...
  10. doi request reprint Adeno-associated virus-mediated human acidic fibroblast growth factor expression promotes functional recovery of spinal cord-contused rats
    Wen Cheng Huang
    Centre for Neural Regeneration, Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
    J Gene Med 13:283-9. 2011
    ..In previous studies, we showed that acidic fibroblast growth factor (aFGF) is a potent neurotrophic factor that promotes the regeneration of axotomized spinal cord or dorsal root ganglion neurones...
  11. doi request reprint Dynamic stabilization for degenerative spondylolisthesis: evaluation of radiographic and clinical outcomes
    Li Yu Fay
    Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taiwan
    Clin Neurol Neurosurg 115:535-41. 2013
    ..To evaluate the dynamic stabilization system in degenerative lumbar spondylolisthesis...
  12. doi request reprint Younger boys have a higher risk of inguinal hernia after ventriculo-peritoneal shunt: a 13-year nationwide cohort study
    Jau Ching Wu
    Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
    J Am Coll Surg 214:845-51. 2012
    ..These institutional-based data have small numbers and provided little information about the effects of age and sex. This study aims to examine the incidences and risk factors of IH in children with hydrocephalus treated with VPS...
  13. doi request reprint A novel strategy for repairing preganglionic cervical root avulsion in brachial plexus injury by sural nerve grafting
    Jau Ching Wu
    Department of Neurosurgery, Taipei Veterans General Hospital, Taipei, Taiwan
    J Neurosurg 110:775-85. 2009
    ....
  14. pmc Enhanced prostacyclin synthesis by adenoviral gene transfer reduced glial activation and ameliorated dopaminergic dysfunction in hemiparkinsonian rats
    May Jywan Tsai
    Neural Regeneration Laboratory, Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei 11221, Taiwan
    Oxid Med Cell Longev 2013:649809. 2013
    ..Prostacyclin may have a neuroprotective role in modulating the inflammatory response in degenerating nigra-striatal pathway...
  15. pmc Lumbar spine fusion surgery and stroke: a national cohort study
    Jau Ching Wu
    Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
    Eur Spine J 21:2680-7. 2012
    ..To investigate the incidence and risk of stroke after lumbar spinal fusion surgery...
  16. doi request reprint The incidence of adjacent segment disease requiring surgery after anterior cervical diskectomy and fusion: estimation using an 11-year comprehensive nationwide database in Taiwan
    Jau Ching Wu
    Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
    Neurosurgery 70:594-601. 2012
    ..9%/y in a previous cohort of 374 patients. Few other data corroborate the incidence and natural history of ASD...
  17. doi request reprint Epidemiology of cervical spondylotic myelopathy and its risk of causing spinal cord injury: a national cohort study
    Jau Ching Wu
    Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
    Neurosurg Focus 35:E10. 2013
    ..This study aimed to determine the age- and sex-specific incidence of cervical spondylotic myelopathy (CSM) and its associated risk of causing subsequent spinal cord injury (SCI)...
  18. doi request reprint Silymarin protects spinal cord and cortical cells against oxidative stress and lipopolysaccharide stimulation
    May Jywan Tsai
    Neural Regeneration Laboratory, Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taiwan
    Neurochem Int 57:867-75. 2010
    ..Taken together, silymarin or silybin shows promise in protecting the CNS cells from toxin- or injury-induced damages and might be used to treat head- or spinal cord-injuries related to free radical assault...
  19. doi request reprint Conservatively treated ossification of the posterior longitudinal ligament increases the risk of spinal cord injury: a nationwide cohort study
    Jau Ching Wu
    Institute of Pharmacology, National Yang Ming University, Taipei, Taiwan
    J Neurotrauma 29:462-8. 2012
    ..72, adjusted HR=104.78; p<0.001) for the OPLL group. Therefore, cervical SCI and related disabilities are more likely to happen in OPLL patients, who should be cautioned for subsequent SCI if treated conservatively...
  20. doi request reprint Acidic fibroblast growth factor for repair of human spinal cord injury: a clinical trial
    Jau Ching Wu
    Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
    J Neurosurg Spine 15:216-27. 2011
    ..The study aimed to verify the safety and feasibility of applying acidic fibroblast growth factor (aFGF) with fibrin glue in combination with surgical neurolysis for nonacute spinal cord injury...
  21. ncbi request reprint Dual effect of adenovirus-mediated transfer of BMP7 in mixed neuron-glial cultures: neuroprotection and cellular differentiation
    May Jywan Tsai
    Neural Regeneration Laboratory, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
    J Neurosci Res 85:2950-9. 2007
    ..Concurrently, it profoundly reduces microglial numbers, but increases oligodendroglial and endothelial cells. Together, low-dose and continuously expressed BMP7 is both neuroprotective and differentiation-inductive...
  22. doi request reprint Pedicle screw loosening in dynamic stabilization: incidence, risk, and outcome in 126 patients
    Jau Ching Wu
    Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
    Neurosurg Focus 31:E9. 2011
    ..The long-term outcome of lumbar dynamic stabilization is uncertain. This study aimed to investigate the incidence, risk factors, and outcomes associated with screw loosening in a dynamic stabilization system...
  23. doi request reprint Evaluation of the antiangiogenic effect of Kringle 1-5 in a rat glioma model
    Yi Lo Lin
    Neural Regeneration Laboratory, Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
    Neurosurgery 70:479-89; discussion 489-90. 2012
    ..Kringle 1-5 (K1-5) is a potent antiangiogenesis factor for treating breast cancer and hepatocellular carcinoma. However, its use in treating brain tumors has not been studied...
  24. doi request reprint Enhanced expression of glycine N-methyltransferase by adenovirus-mediated gene transfer in CNS culture is neuroprotective
    May Jywan Tsai
    Neural Regeneration Laboratory, Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
    Ann N Y Acad Sci 1199:194-203. 2010
    ..Taken together, enhanced GNMT expression in mixed neuronal-glial cultures is neuroprotective, most likely mediated through non-neuronal cells...
  25. doi request reprint The risk of stroke after spinal fusion surgery: a national cohort study
    Jau Ching Wu
    Institute of Pharmacology, National Yang Ming University, 2F, No 322, Shih Pai Rd, Sec 2, Peitou, Taipei 11217, Taiwan
    Spine J 12:492-9. 2012
    ..Postoperative stroke is a rare complication of spinal fusion surgery, but its relevant risk and incidence remain unclear...
  26. doi request reprint Outcomes of common peroneal nerve lesions after surgical repair with acidic fibroblast growth factor
    Po Yi Tsai
    Department of Physical Medicine and Rehabilitation, Taipei Veterans General Hospital, Taipei, Taiwan
    J Trauma 66:1379-84. 2009
    ..Our interest was focused on the question of whether a repair strategy incorporating growth factors could be applied to repair of common peroneal nerve lesions...
  27. doi request reprint One-stage posterior resection is feasible for a holovertebral aneurysmal bone cyst of the axis: a case report and literature review
    Li Yu Fay
    Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    Surg Neurol 72:S80-5. 2009
    ..For cervical spine ABC, staged surgery and the combination of both anterior and posterior approaches are usually necessary for lesions involving all 3 (anterior, middle, and posterior) columns of the spine (holovertebral)...
  28. doi request reprint PAL31 may play an important role as inflammatory modulator in the repair process of the spinal cord injury rat
    Li Fen Shen
    The Institute of Biochemistry and Molecular Biology, National Yang Ming University, Taipei, Taiwan
    J Neurochem 108:1187-97. 2009
    ..These experimental results suggest that PAL31 may involve in the modulation of the inflammatory response and, at the same time, prevent apoptosis process of macrophage after SCI...
  29. ncbi request reprint The neuroprotective effect of glial cell line-derived neurotrophic factor in fibrin glue against chronic focal cerebral ischemia in conscious rats
    Henrich Cheng
    Center for Neural Regeneration, Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan ROC
    Brain Res 1033:28-33. 2005
    ..We concluded GDNF-fibrin glue could facilitate delivery of GDNF to the damaged brain tissue with subsequent reduction of ischemic brain injury accompanied by enhancing functional recovery in rats with chronic FCI injury...
  30. ncbi request reprint The combination of peripheral nerve grafts and acidic fibroblast growth factor enhances arginase I and polyamine spermine expression in transected rat spinal cords
    Huai Sheng Kuo
    Neural Regeneration Laboratory, Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
    Biochem Biophys Res Commun 357:1-7. 2007
    ..Thus, in addition to enhancing the expression of Arg I and spermine in repaired spinal cords, our treatment may recruit activated macrophages and create a more favorable environment for axonal regrowth...
  31. doi request reprint Use of screw-rod system in occipitocervical fixation
    Yu Hone Hsu
    Division of Neurosurgery, Department of Surgery, Far Eastern Memorial Hospital, Taipei, Taiwan, R O C
    J Chin Med Assoc 72:20-8. 2009
    ..The objective was to evaluate the clinical result of occipitocervical fixation with the screw-rod fixation system, including symptom relief, fusion rate and complications...
  32. doi request reprint Gait analysis of spinal cord injured rats after delivery of chondroitinase ABC and adult olfactory mucosa progenitor cell transplantation
    Wen Cheng Huang
    Center for Neural Regeneration, Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    Neurosci Lett 472:79-84. 2010
    ..The gait characteristics of treated rats on a treadmill were consistent and approached that of intact rats. In future, the mechanism of restoring the injured spinal cord will be further investigated...
  33. ncbi request reprint Multilevel arthroplasty for cervical spondylosis: more heterotopic ossification at 3 years of follow-up
    Jau Ching Wu
    Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
    Spine (Phila Pa 1976) 37:E1251-9. 2012
    ..Retrospective cohort study...
  34. doi request reprint The effects of carpentry on heterotopic ossification and mobility in cervical arthroplasty: determination by computed tomography with a minimum 2-year follow-up: Clinical article
    Tsung Hsi Tu
    Department of Neurosurgery, Taipei Veterans General Hospital, Taipei, Tawan
    J Neurosurg Spine 16:601-9. 2012
    ..In this study the authors used CT scanning to assess the formation of HO with the goal of investigating the correlation between the carpentry of arthroplasty, formation of HO, mobility, and clinical outcomes...
  35. doi request reprint Vertebral body split fracture after a single-level cervical total disc replacement
    Tsung Hsi Tu
    Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
    J Neurosurg Spine 16:231-5. 2012
    ..Although the linear fracture caused no neurological symptoms or device migration, the authors advocate prudence in selection and installation of keel-design prostheses, even in a single-level cervical TDR scenario...
  36. doi request reprint Differences between 1- and 2-level cervical arthroplasty: more heterotopic ossification in 2-level disc replacement: Clinical article
    Jau Ching Wu
    Departmentsof Neurosurgery, Taipei Veterans General Hospital, Taipei, Taiwan
    J Neurosurg Spine 16:594-600. 2012
    ..This study aimed to investigate the differences between 1- and 2-level cervical arthroplasty...
  37. doi request reprint Should Cervical Disc Arthroplasty Be Done on Patients with Increased Intramedullary Signal Intensity on Magnetic Resonance Imaging?
    Hsuan Kan Chang
    Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan School of Medicine, National Yang Ming University, Taipei, Taiwan
    World Neurosurg 89:489-96. 2016
    ..This study aimed to evaluate the outcomes of CDA for patients with IISI on preoperative MRI...
  38. doi request reprint Dynesys dynamic stabilization-related facet arthrodesis
    Li Yu Fay
    Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital
    Neurosurg Focus 40:E4. 2016
    ..However, unintended facet arthrodesis did not affect the clinical outcomes during the study period. Further evaluations are needed to clarify the actual significance of this phenomenon. ..
  39. pmc Cervical Arthroplasty for Traumatic Disc Herniation: An Age- and Sex-matched Comparison with Anterior Cervical Discectomy and Fusion
    Hsuan Kan Chang
    Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Room 508, 17F, No 201, Shih Pai Road, Sec 2, Beitou, Taipei, 11217, Taiwan
    BMC Musculoskelet Disord 16:228. 2015
    ..However, there are scant data on using cervical arthroplasty for traumatic disc herniation. Therefore, this study aimed to investigate the outcomes of patients who underwent cervical arthroplasty for traumatic disc herniation...
  40. pmc Tetramethylpyrazine inhibits activities of glioma cells and glutamate neuro-excitotoxicity: potential therapeutic application for treatment of gliomas
    Yu Show Fu
    Department of Anatomy, School of Medicine, National Yang Ming University, 155 Sec 2 Li Nung Street, Taipei, Taiwan
    Neuro Oncol 10:139-52. 2008
    ..The results indicate that TMP can suppress glioma activity, including growth, and protect neurons against glioma-induced excitotoxicity, suggesting that TMP may have therapeutic potential in the treatment of malignant gliomas...
  41. pmc Involvement of acidic fibroblast growth factor in spinal cord injury repair processes revealed by a proteomics approach
    Ming Chu Tsai
    Institute of Biochemistry and Molecular Biology, School of Life Sciences, National Yang Ming University, Taipei 11221, Taiwan
    Mol Cell Proteomics 7:1668-87. 2008
    ..Thus, our results could have a remarkable impact on clinical developments in the area of spinal cord injury therapy...
  42. ncbi request reprint Resveratrol neuroprotective effects during focal cerebral ischemia injury via nitric oxide mechanism in rats
    Shen Kou Tsai
    Department of Anesthesiology, College of Medicine, Buddhist Tzu Chi University and Hospital, Taipei, Taiwan
    J Vasc Surg 46:346-53. 2007
    ..Therefore, this study was designed to investigate the role of nitric oxide on the neuroprotective mechanisms of resveratrol on rats after FCI injury...
  43. pmc The risk of stroke after percutaneous vertebroplasty for osteoporosis: a population-based cohort study
    Ching Lan Wu
    Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan
    PLoS ONE 7:e31405. 2012
    ..To investigate the incidence and risk of stroke after percutaneous vertebroplasty in patients with osteoporosis...
  44. doi request reprint Differences between soft-disc herniation and spondylosis in cervical arthroplasty: CT-documented heterotopic ossification with minimum 2 years of follow-up
    Jau Ching Wu
    Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Beitou, Taipei 11217, Taiwan
    J Neurosurg Spine 16:163-71. 2012
    ....
  45. ncbi request reprint Repair of multiple cervical root avulsion with sural nerve graft
    Sanford P C Hsu
    Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, National Yang Ming University, Taipei, Taiwan, ROC
    Injury 35:896-907. 2004
    ..0313). We were impressed that the initial significant statistical results of differences in pre- and post-operative severity of the injuries and muscle power grading, demonstrated that regeneration does occur with this repair strategy...
  46. ncbi request reprint Spinal cord repair with acidic fibroblast growth factor as a treatment for a patient with chronic paraplegia
    Henrich Cheng
    Department of Neurosurgery, Taipei Veterans General Hospital and National Yang Ming University School of Medicine, Taipei, Taiwan
    Spine (Phila Pa 1976) 29:E284-8. 2004
    ..We present a case of a patient with chronic paraplegia with a complete spinal cord gap resulting from a stabbing injury 4 years ago recovering after an innovative surgical strategy...
  47. doi request reprint Primary Endoscopic Transnasal Transsphenoidal Surgery for Giant Pituitary Adenoma
    Chao Hung Kuo
    Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan Faculty of Medicine, School of Medicine, National Yang Ming University, Taipei, Taiwan
    World Neurosurg 91:121-8. 2016
    ..Giant pituitary adenoma (>4 cm) remains challenging because the optimal surgical approach is uncertain...
  48. pmc The Effect of Lumbar Lordosis on Screw Loosening in Dynesys Dynamic Stabilization: Four-Year Follow-Up with Computed Tomography
    Chao Hung Kuo
    Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, 17F, No 201, Shih Pai Road, Sec 2, Beitou, Taipei 11217, Taiwan School of Medicine, National Yang Ming University, Taiwan
    Biomed Res Int 2015:152435. 2015
    ..This study aimed to evaluate the effects of Dynesys dynamic stabilization (DDS) on clinical and radiographic outcomes, including spinal pelvic alignment...
  49. doi request reprint Dynamic stabilization for L4-5 spondylolisthesis: comparison with minimally invasive transforaminal lumbar interbody fusion with more than 2 years of follow-up
    Chao Hung Kuo
    Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital
    Neurosurg Focus 40:E3. 2016
    ..However, unlike fusion, dynamic implants have issues of wearing and loosening in the long term. Thus, the comparable results between the 2 groups in this study require longer follow-up to corroborate. ..
  50. pmc Local Delivery of High-Dose Chondroitinase ABC in the Sub-Acute Stage Promotes Axonal Outgrowth and Functional Recovery after Complete Spinal Cord Transection
    Chu Hsun Cheng
    Program in Molecular Medicine, National Yang Ming University and Academia Sinica, Taipei, Taiwan Institute of Pharmacology, School of Medicine, National Yang Ming University, Taipei, Taiwan Neural Regeneration Laboratory, Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
    PLoS ONE 10:e0138705. 2015
    ..Thus, our results will aid in the treatment of spinal cord injury. ..
  51. pmc Transplantation of human umbilical mesenchymal stem cells from Wharton's jelly after complete transection of the rat spinal cord
    Chang Ching Yang
    Institute of Anatomy and Cell Biology, School of Medicine, National Yang Ming University, Taipei, Taiwan, Republic of China
    PLoS ONE 3:e3336. 2008
    ..These cells may be a valuable source in the repair of spinal cord injury...
  52. doi request reprint Endoscope-assisted minimally invasive transforaminal thoracic interbody fusion
    Chih Hsiang Liao
    Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    Neurosurg Focus 35:Video 11. 2013
    ..Thoracic interbody fusion can be achieved through a minimally invasive approach from the back. The video can be found here: http://youtu.be/54rRMtvSyCM...
  53. pmc Differences between arthroplasty and anterior cervical fusion in two-level cervical degenerative disc disease
    Li Yu Fay
    Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Room 509, 17F, No 201, Shih Pai Road, Sec 2, Beitou, Taipei, 11217, Taiwan
    Eur Spine J 23:627-34. 2014
    ..The current study was designed to determine differences between two-level cervical arthroplasty and anterior fusion...
  54. doi request reprint Quantitative measures of functional outcomes and quality of life in patients with C5 palsy
    Po Yao Chang
    Department of Physical Medicine and Rehabilitation, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    J Chin Med Assoc 76:378-84. 2013
    ....
  55. doi request reprint Nerve repair using acidic fibroblast growth factor in human cervical spinal cord injury: a preliminary Phase I clinical study
    Jau Ching Wu
    Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taiwan
    J Neurosurg Spine 8:208-14. 2008
    ..The aim of this study was to assess functional outcomes of nerve repair using acidic fibroblast growth factor (FGF) in patients with cervical spinal cord injury (SCI)...
  56. doi request reprint Increased risk of stroke after spinal cord injury: a nationwide 4-year follow-up cohort study
    Jau Ching Wu
    Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
    Neurology 78:1051-7. 2012
    ..This study aimed to evaluate the incidence of stroke in patients with disability caused by SCI...
  57. doi request reprint Endoscopic transnasal transclival odontoidectomy: a new approach to decompression: technical case report
    Jau Ching Wu
    Neural Regeneration Laboratory, Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, National Yang Ming University, Taipei, Taiwan, Republic of China
    Neurosurgery 63:ONSE92-4; discussion ONSE94. 2008
    ..Endoscopic transnasal transclival resection of the odontoid process is less invasive than the standard transoral odontoidectomy. In this article, we describe our techniques, which are less invasive but provide successful decompression...
  58. doi request reprint Screw loosening in the Dynesys stabilization system: radiographic evidence and effect on outcomes
    Chin Chu Ko
    Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
    Neurosurg Focus 28:E10. 2010
    ..Loosening of the pedicle screws in such nonfusion implants is predictable. This retrospective study evaluated the incidence of screw loosening and its effect on clinical outcomes...
  59. doi request reprint Stepwise illustration of teeth-fixation semi-constrained cervical disc arthroplasty
    Chih Chang Chang
    Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital
    Neurosurg Focus 42:V4. 2017
    ..The follow-up images demonstrated preservation of motion at the indexed level. The video can be found here: https://youtu.be/4DSES1xgvQU ...
  60. doi request reprint Hydrocephalus Caused by Fat Embolism: A Rare Complication of Atlanto-Axial Fixation for Odontoid Fractures
    Chun Hao Wang
    Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan School of Medicine, National Yang Ming University, Taipei, Taiwan
    World Neurosurg 90:700.e7-700.e12. 2016
    ..This is the first report of delayed hydrocephalus due to subarachnoid fat migration as a complication of posterior atlanto-axial (AA) fixation...
  61. doi request reprint Endoscopic transnasal odontoidectomy without resection of nasal turbinates: clinical outcomes of 13 patients
    Yu Shu Yen
    Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital and
    J Neurosurg Spine 21:929-37. 2014
    ..This approach is minimally invasive and causes little velopharyngeal insufficiency. The pitfall of this approach is the difficulty in repairing dural defects and subsequent CSF leakage. ..
  62. doi request reprint Postoperative nonsteroidal antiinflammatory drugs and the prevention of heterotopic ossification after cervical arthroplasty: analysis using CT and a minimum 2-year follow-up
    Tsung Hsi Tu
    Department of Neurosurgery, Neurological Institute, and
    J Neurosurg Spine 22:447-53. 2015
    ..However, the study was limited by the number of patients included, and the efficacy of NSAIDs in the prevention of HO after cervical arthroplasty may need further investigation to confirm these results. ..
  63. ncbi request reprint Effect of enhanced prostacyclin synthesis by adenovirus-mediated transfer on lipopolysaccharide stimulation in neuron-glia cultures
    May Jywan Tsai
    Neural Regeneration Laboratory, Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Shih Pai Road, Sec 2, Taipei, Taiwan 11217
    Ann N Y Acad Sci 1042:338-48. 2005
    ..Taken together, enhanced prostacyclin synthesis in neuron-glial cultures reduced microglia number and suppressed LPS stimulation...
  64. doi request reprint New nerve regeneration strategy combining laminin-coated chitosan conduits and stem cell therapy
    Sung Hao Hsu
    Institute of Zoology, College of Life Science, National Taiwan University, Taipei, Taiwan, ROC
    Acta Biomater 9:6606-15. 2013
    ..In summary, this study suggests that LN-modified chitosan multi-walled nerve conduit combined with BMSCs is an efficient and safe conduit matrix for nerve regeneration...
  65. pmc Intervertebral disc rehydration after lumbar dynamic stabilization: magnetic resonance image evaluation with a mean followup of four years
    Li Yu Fay
    Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei 11217, Taiwan School of Medicine, National Yang Ming University, Taipei 11221, Taiwan Institute of Pharmacology, National Yang Ming University, Taipei 11221, Taiwan
    Adv Orthop 2013:437570. 2013
    ..Conclusions. There is significant clinical improvement after laminectomy and dynamic stabilization for symptomatic lumbar spinal stenosis. Intervertebral disc rehydration was seen in younger patients...
  66. doi request reprint Heterotopic ossification after cervical total disc replacement: determination by CT and effects on clinical outcomes
    Tsung Hsi Tu
    Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Beitou, Taipei, Taiwan
    J Neurosurg Spine 14:457-65. 2011
    ..The aims of this study were to assess the actual incidence of HO and its effect on outcome in a cohort of patients undergoing cervical TDR with the Bryan disc and to compare HO detection by means of plain radiographs and CT...
  67. doi request reprint Stabilization of subaxial cervical spines by lateral mass screw fixation with modified Magerl's technique
    Jau Ching Wu
    Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, School of Medicine, National Yang Ming University, Taipei 11217, Taiwan, ROC
    Surg Neurol 70:S1:25-33; discussion S1:33. 2008
    ..We have applied this modified technique on a large series of patients and obtained satisfactory results...
  68. ncbi request reprint Concordance and discrepancy between electrodiagnosis and magnetic resonance imaging in cervical root avulsion injuries
    Po Yi Tsai
    Department of Physical Medicine and Rehabilitation, Taipei Veterans General Hospital, Taipei, Taiwan
    J Neurotrauma 23:1274-81. 2006
    ..Both EMG and the MRI play crucial roles in preoperative assessment, and they may complement each other...
  69. ncbi request reprint Conversion of human umbilical cord mesenchymal stem cells in Wharton's jelly to dopaminergic neurons in vitro: potential therapeutic application for Parkinsonism
    Yu Show Fu
    155 Sec 2, Li Nung Street, 112, Department of Anatomy, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Stem Cells 24:115-24. 2006
    ..4 mm both rostrally and caudally. These results suggest that human umbilical mesenchymal stem cells have the potential for treatment of Parkinson's disease...
  70. doi request reprint Repairing the ventral root is sufficient for simultaneous motor and sensory recovery in multiple complete cervical root transection injuries
    Yi Lo Lin
    Graduate Institute of Veterinary Pathobiology, College of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan Neural Regeneration Laboratory, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
    Life Sci 109:44-9. 2014
    ..In this study, the authors evaluated whether repairing ventral root alone is sufficient for simultaneous sensory and motor function recovery...
  71. doi request reprint Remote cerebellar hemorrhage after cervical spinal surgery
    Po Hsien Huang
    Division of Neurosurgery, Department of Surgery, Taoyuan Branch, Taipei Veterans General Hospital, Taoyuan, Taiwan, ROC National Yang Miing University School of Medicine, Taipei, Taiwan, ROC
    J Chin Med Assoc 76:593-8. 2013
    ..We also underline the importance of early diagnosis and CSF expansion in the early treatment of RCH. ..
  72. doi request reprint Intracranial subdural hematoma coexisting with improvement in spontaneous intracranial hypotension after an epidural blood patch
    Cheng Hsi Chang
    Department of Anesthesiology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan, ROC
    J Chin Med Assoc 75:610-3. 2012
    ..In summary, intracranial SDH can be a complication of inadequately treated SIH (i.e. persistent minor CSF leakage). Management of SDH should focus on correction of the underlying SIH rather than craniotomy for hematoma evacuation...
  73. ncbi request reprint Acidic FGF enhances functional regeneration of adult dorsal roots
    Liang Ming Lee
    Department of Urology, Taipei Medical University, Taipei Municipal Wan Fang Hospital, Taipei, Taiwan
    Life Sci 74:1937-43. 2004
    ..Cortical SEPs is considered a useful tool in evaluating such regeneration. These results may offer therapeutic potential in the treatment of dorsal root injuries...
  74. ncbi request reprint Chondroitinase ABC promotes axonal re-growth and behavior recovery in spinal cord injury
    Wen Cheng Huang
    Center for Neural Regeneration, Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, No 201 Shih Pai Road, Taipei 11217, Taiwan, ROC
    Biochem Biophys Res Commun 349:963-8. 2006
    ....
  75. ncbi request reprint Spinal cord implantation with acidic fibroblast growth factor as a treatment for root avulsion in obstetric brachial plexus palsy
    Pei Hsin Lin
    Division of Nerve Repair, Department of Neurosurgery, Neurological Institute, Taipei, Taiwan
    J Chin Med Assoc 68:392-6. 2005
    ..After 2 years of follow-up, there has been significant improvement in motor function and in electrophysiologic studies over the left upper limb...
  76. ncbi request reprint Laminin-incorporated nerve conduits made by plasma treatment for repairing spinal cord injury
    Henrich Cheng
    Neurosurgery Neurological Institute, Taipei Veterans General Hospital, National Taiwan University, Taipei 10617, Taiwan
    Biochem Biophys Res Commun 357:938-44. 2007
    ..These results suggest a new possible approach to repairing SCI and, in general, a model which will be useful for other multidisciplinary procedures for complex neurological situations...
  77. ncbi request reprint Kainic acid-induced oxidative injury is attenuated by hypoxic preconditioning
    Cheng Hao Wang
    Department of Physiology, National Yang Ming University, Taipei, Taiwan
    Ann N Y Acad Sci 1042:314-24. 2005
    ..Our data suggest that hypoxic preconditioning exerts its neuroprotection of KA-induced oxidative injury via enhancing NF-kappaB activation, upregulating the antioxidative defense system, and attenuating the apoptotic process...
  78. doi request reprint Intermittent theta burst stimulation over ipsilesional primary motor cortex of subacute ischemic stroke patients: a pilot study
    Ya Fang Hsu
    Institute of Brain Science, National Yang Ming University, Taipei, Taiwan
    Brain Stimul 6:166-74. 2013
    ....
  79. doi request reprint Ossification of the posterior longitudinal ligament in the cervical spine: an 11-year comprehensive national epidemiology study
    Jau Ching Wu
    Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
    Neurosurg Focus 30:E5. 2011
    ..This study aimed to calculate the incidence and prevalence of ossification of the posterior longitudinal ligament (OPLL) in the cervical spine with its comorbid disability...
  80. ncbi request reprint Malignancy of intracerebral lesions evaluated with 11C-methionine-PET
    Ming Chao Huang
    Neural Regeneration Laboratory, Department of Neurosurgery, Taipei Veterans General Hospital, Taipei, Taiwan
    J Clin Neurosci 12:775-80. 2005
    ..We conclude that met-PET may be a reliable and effective preoperative evaluation to determine the type and malignancy of intraparenchymal brain lesions...
  81. doi request reprint Herpes zoster cervical myelitis in a young adult
    Cheng Chia Lee
    Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    J Chin Med Assoc 73:605-10. 2010
    ..We therefore propose that early medical intervention is necessary for better and earlier recovery...
  82. ncbi request reprint Cervical spinal stenosis and myelopathy due to atlas hypoplasia
    Yu Hone Hsu
    Division of Neurosurgery, Department of Surgery, Far Eastern Memorial Hospital, Taipei, Taiwan, R O C
    J Chin Med Assoc 70:339-44. 2007
    ..Current treatment is surgical decompression, and all reported patients receiving surgical treatment improved to some degree...
  83. ncbi request reprint The comparison of electrophysiologic findings of traumatic brachial plexopathies in a tertiary care center
    Tien Yow Chuang
    Department of Physical Medicine and Rehabilitation, Taipei Veterans General Hospital, National Yang Ming University, 201 Shih Pai Road, Sec 2, Peitou, 11217, ROC, Taipei, Taiwan
    Injury 33:591-5. 2002
    ..Moreover, the majority of patients in the motorcycle, fall, and pedestrian groups suffered from severe, incomplete lesions, while the neurophysiological results of the other groups varied...
  84. ncbi request reprint A virtual reality-based system for hand function analysis
    Tien Yow Chuang
    Department of Physical Medicine and Rehabilitation, Veterans General Hospital Taipei and National Yang Ming University, No 201 Shih Pai Rd, Sec 2, 11217, Taipei, Taiwan
    Comput Methods Programs Biomed 69:189-96. 2002
    ..Although rehabilitation clinics routinely carry out peg-moving exercises for disabled patients, our model provides a valuable quantitative real time and off-line measure of whole hand functions...
  85. ncbi request reprint Loss of interhemispheric inhibition on the ipsilateral primary sensorimotor cortex in patients with brachial plexus injury: fMRI study
    Jen Chuen Hsieh
    Integrated Brain Research Laboratory, Department of Medical Research and Education, Taipei Veterans General Hospital, Taiwan
    Ann Neurol 51:381-5. 2002
    ..We propose that the disappearance of the antagonistic pattern of SM1 activities in the patients with brachial plexus injury reflects a reduction of interhemispheric inhibition, which may mirror an adaptive mechanism to functional status...
  86. ncbi request reprint Gene transfer into human keloid tissue with adeno-associated virus vector
    Hsu Ma
    School of Medicine, NationalYang Ming University and Department of Neurosurgery, Veterans General Hospital Taipei, Taiwan
    J Trauma 54:569-73. 2003
    ..CONCLUSION Our results showed that AAV vector could transduce human keloid tissue effectively. Replacement of the reporter gene with a functioning gene might be feasible for keloid treatment...
  87. ncbi request reprint Posterior transarticular screw fixation for chronic atlanto-axial instability
    Muh Lii Liang
    Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    J Clin Neurosci 11:368-72. 2004
    ..It allows good neurological recovery in cases of chronic atlanto-axial instability. Judicious pre-surgical planning and meticulous operative technique may avoid neurological complications and vertebral artery injury...
  88. doi request reprint Occult occipital condyle fracture with normal neurological function and torticollis
    Chiang Wei Chou
    Department of Neurosurgery, Neurological Institute, Veteran s General Hospital Taipei, Taiwan
    J Clin Neurosci 15:920-2. 2008
    ..The patient recovered well without adverse sequelae. We conclude that physicians should be alert to the possibility of occipital condyle fracture in trauma patients...
  89. doi request reprint Magnetic resonance imaging guided biopsy of musculoskeletal lesions
    Hung Ta H Wu
    Department of Radiology, Taipei Veterans General Hospital, National Yang Ming University School of Medicine, Taipei, Taiwan, ROC
    J Chin Med Assoc 75:160-6. 2012
    ..The purpose of this study was to clinically test and evaluate the efficacy of the magnetic resonance imaging (MRI)-guidance techniques for obtaining musculoskeletal biopsies using the appropriate imaging modalities and instruments...
  90. ncbi request reprint In vitro differentiation of size-sieved stem cells into electrically active neural cells
    Shih Chieh Hung
    Department of Orthopaedics, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Stem Cells 20:522-9. 2002
    ..These findings suggest that SS cells may be an alternative source of undifferentiated cells for cell therapy and gene therapy in neural dysfunction...
  91. doi request reprint The correlation between ventricular repolarization and clinical severity of spinal cord injuries
    Fa Po Chung
    Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Heart Rhythm 8:879-84. 2011
    ..Alteration in ventricular repolarization has been reported in patients with spinal cord injuries (SCIs). However, its clinical impact remains unclear...
  92. ncbi request reprint Cervical root repair in adult rats after transection: recovery of forelimb motor function
    Ming Chao Huang
    Neural Regeneration Laboratory, Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, No 201 Shih Pai Road, Section 2, Taipei, Taiwan 11217
    Exp Neurol 180:101-9. 2003
    ..It is our belief that this novel treatment strategy may help patients with similar injuries in the future...
  93. ncbi request reprint Neuroprotection of glial cell line-derived neurotrophic factor in damaged spinal cords following contusive injury
    Henrich Cheng
    Neural Regeneration Laboratory, Neurological Institute, Taipei Veterans General Hospital, Taiwan
    J Neurosci Res 69:397-405. 2002
    ..Together our results show that GDNF exerts behavioral and anatomic neuroprotection following SCI. Additionally, GDNF-activated MAP kinase and Bcl-2 signaling may contribute to neuronal survival after spinal cord contusion...
  94. ncbi request reprint Quantification of electroacupuncture-induced neural activity by analysis of functional neural imaging with monocrystalline iron oxide nanocolloid enhancement
    Shao Chang Ho
    Institute of Traditional Chinese Medicine, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Am J Chin Med 36:493-504. 2008
    ..This study suggests that fMRI with AFNI is a good approach to quantifying brain activities. This innovative method brings new perspective into the mechanisms of acupuncture...
  95. ncbi request reprint Gene transfer of glial cell line-derived neurotrophic factor promotes functional recovery following spinal cord contusion
    Ming Hong Tai
    Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
    Exp Neurol 183:508-15. 2003
    ..This research should provide information for developing a clinical strategy for GDNF gene therapy...
  96. ncbi request reprint Neuronal morphological change of size-sieved stem cells induced by neurotrophic stimuli
    Shun Fen Tzeng
    Department of Biology, National Cheng Kung University, Tainan City, Taiwan ROC
    Neurosci Lett 367:23-8. 2004
    ..The findings indicate that neurotrophic signaling and cAMP-dependent signaling might promote the neuronal differentiation of SSCs...
  97. ncbi request reprint Forelimb muscle activity following nerve graft repair of ventral roots in the rat cervical spinal cord
    Tien Yow Chuang
    Neurophysiologic Laboratory, Department of Physical Medicine and Rehabilitation, Taipei Veterans General Hospital and National Yang Ming University, Taiwan
    Life Sci 71:487-96. 2002
    ..8316, G3 = 57.4262, generalized estimating equation). We conclude that several cervical roots can regenerate through intercostal nerve grafts applied using fibrin glue. Adding aFGF may increase the efficacy of sprouting...