Yuh Min Chen

Summary

Affiliation: Taipei Veterans General Hospital
Country: Taiwan

Publications

  1. ncbi request reprint Gefitinib treatment is highly effective in non-small-cell lung cancer patients failing previous chemotherapy in Taiwan: a prospective phase II study
    Yuh Min Chen
    Chest Department, Taipei Veterans General Hospital, School of Medicine, National Yang Ming University, Taipei 112, Taiwan, ROC
    J Chemother 17:679-84. 2005
  2. ncbi request reprint A phase II trial of gemcitabine plus UFUR combination chemotherapy in non-small-cell lung cancer patients failing previous chemotherapy
    Yuh Min Chen
    Chest Department, Taipei Veterans General Hospital, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Lung Cancer 52:333-8. 2006
  3. ncbi request reprint Gefitinib as front-line treatment in Chinese patients with advanced non-small-cell lung cancer
    Wei Chun Lin
    Chest Department, Taipei Veterans General Hospital, Taipei, Taiwan
    Lung Cancer 54:193-9. 2006
  4. ncbi request reprint A phase II study of oral vinorelbine in combination with cisplatin conducted in Taiwan in patients with unresectable localized or metastatic non-small cell lung carcinoma
    Yuh Min Chen
    Chest Department, Taipei Veterans General Hospital, School of Medicine, National Yang Ming University, Taiwan
    Lung Cancer 56:89-95. 2007
  5. doi request reprint Immune checkpoint inhibitors for nonsmall cell lung cancer treatment
    Yuh Min Chen
    Division of General Chest Medicine, Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC School of Medicine, National Yang Ming Medical University, Taipei, Taiwan, ROC School of Medicine, Taipei Medical University, Taipei, Taiwan, ROC Electronic address
    J Chin Med Assoc 80:7-14. 2017
  6. doi request reprint Update of epidermal growth factor receptor-tyrosine kinase inhibitors in non-small-cell lung cancer
    Yuh Min Chen
    Department of Chest Medicine, Taipei Veterans General Hospital, National Yang Ming University School of Medicine, Taipei, Taiwan, ROC
    J Chin Med Assoc 76:249-57. 2013
  7. doi request reprint Phase II randomized trial of erlotinib or vinorelbine in chemonaive, advanced, non-small cell lung cancer patients aged 70 years or older
    Yuh Min Chen
    Chest Department, Taipei Veterans General Hospital, Taipei, Taiwan
    J Thorac Oncol 7:412-8. 2012
  8. ncbi request reprint Interleukin-2 stimulation activates mesothelial cellular functioning against autologous tumor cells
    Yuh Min Chen
    Chest Department, Taipei Veterans General Hospital and National Yang Ming University School of Medicine, Taipei, Taiwan, ROC
    J Chin Med Assoc 67:323-30. 2004
  9. doi request reprint A phase II randomized study of vinorelbine alone or with cisplatin against chemo-naïve inoperable non-small cell lung cancer in the elderly
    Yuh Min Chen
    Chest Department, Taipei Veterans General Hospital, School of Medicine, National Yang Ming University, Taiwan
    Lung Cancer 61:214-9. 2008
  10. ncbi request reprint A randomized phase II study of vinorelbine plus gemcitabine with/without cisplatin against inoperable non-small-cell lung cancer previously untreated
    Yuh Min Chen
    Chest Department, Taipei Veterans General Hospital, 201, Sec 2, Shih Pai Road, Taipei 112, Taiwan, ROC
    Lung Cancer 47:373-80. 2005

Collaborators

Detail Information

Publications87

  1. ncbi request reprint Gefitinib treatment is highly effective in non-small-cell lung cancer patients failing previous chemotherapy in Taiwan: a prospective phase II study
    Yuh Min Chen
    Chest Department, Taipei Veterans General Hospital, School of Medicine, National Yang Ming University, Taipei 112, Taiwan, ROC
    J Chemother 17:679-84. 2005
    ....
  2. ncbi request reprint A phase II trial of gemcitabine plus UFUR combination chemotherapy in non-small-cell lung cancer patients failing previous chemotherapy
    Yuh Min Chen
    Chest Department, Taipei Veterans General Hospital, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Lung Cancer 52:333-8. 2006
    ..Further treatment with EGFR-TKI is also suggested when patients fail the present treatment...
  3. ncbi request reprint Gefitinib as front-line treatment in Chinese patients with advanced non-small-cell lung cancer
    Wei Chun Lin
    Chest Department, Taipei Veterans General Hospital, Taipei, Taiwan
    Lung Cancer 54:193-9. 2006
    ..This phase II single arm, open label study was designed to evaluate the efficacy and toxicity of oral gefitinib (250mg) daily in previously untreated patients with advanced non-small-cell lung cancer (NSCLC)...
  4. ncbi request reprint A phase II study of oral vinorelbine in combination with cisplatin conducted in Taiwan in patients with unresectable localized or metastatic non-small cell lung carcinoma
    Yuh Min Chen
    Chest Department, Taipei Veterans General Hospital, School of Medicine, National Yang Ming University, Taiwan
    Lung Cancer 56:89-95. 2007
    ..The objective of this phase II study was to define the efficacy of an oral form of vinorelbine combined with cisplatin for first line treatment of advanced/metastatic NSCLC...
  5. doi request reprint Immune checkpoint inhibitors for nonsmall cell lung cancer treatment
    Yuh Min Chen
    Division of General Chest Medicine, Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC School of Medicine, National Yang Ming Medical University, Taipei, Taiwan, ROC School of Medicine, Taipei Medical University, Taipei, Taiwan, ROC Electronic address
    J Chin Med Assoc 80:7-14. 2017
    ..Despite many challenges ahead, immunotherapy with checkpoint inhibitors has already become a new and important treatment modality for lung cancer in the last decade following the discovery of targeted therapy...
  6. doi request reprint Update of epidermal growth factor receptor-tyrosine kinase inhibitors in non-small-cell lung cancer
    Yuh Min Chen
    Department of Chest Medicine, Taipei Veterans General Hospital, National Yang Ming University School of Medicine, Taipei, Taiwan, ROC
    J Chin Med Assoc 76:249-57. 2013
    ..In this report, we review the clinical data of EGFR-TKIs as molecular-targeted therapies in NSCLC...
  7. doi request reprint Phase II randomized trial of erlotinib or vinorelbine in chemonaive, advanced, non-small cell lung cancer patients aged 70 years or older
    Yuh Min Chen
    Chest Department, Taipei Veterans General Hospital, Taipei, Taiwan
    J Thorac Oncol 7:412-8. 2012
    ..The primary objective of this study was to compare the response rates of elderly, chemonaive patients with advanced non-small cell lung cancer (NSCLC) treated with daily oral erlotinib versus oral vinorelbine...
  8. ncbi request reprint Interleukin-2 stimulation activates mesothelial cellular functioning against autologous tumor cells
    Yuh Min Chen
    Chest Department, Taipei Veterans General Hospital and National Yang Ming University School of Medicine, Taipei, Taiwan, ROC
    J Chin Med Assoc 67:323-30. 2004
    ..The present study was designed to determine the different effects of cytokines or antibodies (IL-2, IL-4, IL-7, IL-10, IL-12, alphaCD3) in stimulating the cellular functions of mesothelial cells isolated from malignant pleural effusion...
  9. doi request reprint A phase II randomized study of vinorelbine alone or with cisplatin against chemo-naïve inoperable non-small cell lung cancer in the elderly
    Yuh Min Chen
    Chest Department, Taipei Veterans General Hospital, School of Medicine, National Yang Ming University, Taiwan
    Lung Cancer 61:214-9. 2008
    ..Our aim here was to determine whether or not the addition of cisplatin into vinorelbine (V) treatment is an appropriate regimen for physically fit chemo-naïve non-small cell lung cancer (NSCLC) patients aged 70 or older...
  10. ncbi request reprint A randomized phase II study of vinorelbine plus gemcitabine with/without cisplatin against inoperable non-small-cell lung cancer previously untreated
    Yuh Min Chen
    Chest Department, Taipei Veterans General Hospital, 201, Sec 2, Shih Pai Road, Taipei 112, Taiwan, ROC
    Lung Cancer 47:373-80. 2005
    ..We concluded that the addition of P to VG treatment did increase both the tumor response rate and the toxicities. However, the toxicities were tolerable...
  11. ncbi request reprint Clinical experience with single-agent gemcitabine chemotherapy in patients with non-small-cell lung cancer in whom previous chemotherapy has failed
    Yuh Min Chen
    Chest Department, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    J Chin Med Assoc 68:163-6. 2005
    ..In a phase II study, responses and toxicity to single-agent gemcitabine chemotherapy were evaluated in patients with non-small-cell lung cancer (NSCLC) who had failed previous cisplatin-based chemotherapy...
  12. ncbi request reprint Chemotherapy for non-small cell lung cancer in elderly patients
    Yuh Min Chen
    Chest Department, Taipei Veterans General Hospital, 201, Section 2, Shih Pai Road, Taipei 112, Taiwan
    Chest 128:132-9. 2005
    ..To determine the appropriate chemotherapy regimen for inoperable, chemotherapy-naïve non-small cell lung cancer (NSCLC) in elderly patients...
  13. ncbi request reprint A randomized trial of different docetaxel schedules in non-small cell lung cancer patients who failed previous platinum-based chemotherapy
    Yuh Min Chen
    Chest Department, Taipei Veterans General Hospital, 201, Section 2, Shih Pai Rd, Taipei 112, Taiwan, Republic of China
    Chest 129:1031-8. 2006
    ..Our aim was to evaluate and compare the efficacy of different docetaxel schedules in NSCLC patients who did not respond to previous platinum-based chemotherapy...
  14. ncbi request reprint A randomized phase II study of docetaxel or vinorelbine in combination with cisplatin against inoperable, chemo-naïve non-small-cell lung cancer in Taiwan
    Yuh Min Chen
    Chest Department, Taipei Veterans General Hospital, School of Medicine, National Yang Ming University, Taiwan
    Lung Cancer 56:363-9. 2007
    ..Although both regimens produced a high incidence of severe neutropenia, the majority of patients recovered rapidly without sequelae; and VC treatment is still a standard chemotherapy for Chinese NSCLC patients in Taiwan...
  15. ncbi request reprint Phase II randomized study of daily gefitinib treatment alone or with vinorelbine every 2 weeks in patients with adenocarcinoma of the lung who failed at least 2 regimens of chemotherapy
    Yuh Min Chen
    Chest Department, Taipei Veterans General Hospital, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Cancer 109:1821-8. 2007
    ..The objective of this study was to assess the efficacy of adding chronic, intermittent, low-dose vinorelbine to gefitinib treatment for patients who had adenocarcinoma of the lung who failed>or=2 regimens of chemotherapy...
  16. ncbi request reprint Effect of age on pulmonary metastases and immunotherapy in young and middle-aged mice
    Yuh Min Chen
    Chest Department, Taipei Veterans General Hospital, National Yang Ming University School of Medicine, and Institute of Cancer Research, National Health Research Institutes, Taipei, Taiwan, R O C
    J Chin Med Assoc 70:94-102. 2007
    ....
  17. ncbi request reprint A Phase II randomized study of paclitaxel plus carboplatin or cisplatin against chemo-naive inoperable non-small cell lung cancer in the elderly
    Yuh Min Chen
    Chest Department, Taipei Veterans General Hospital, School of Medicine, National Yang Ming University, Taipei, Taiwan
    J Thorac Oncol 1:141-5. 2006
    ..5 months in the CIS arm. In conclusion, paclitaxel plus CAR or CIS treatment is feasible in elderly patients and has similar activity. However, paclitaxel plus CAR had less non-hematological toxicity than paclitaxel plus CIS...
  18. doi request reprint Survival status of veterans with lung cancer is poorer than that among civilians due to age and sex differences: a study of Chinese veterans in Taiwan
    Yuh Min Chen
    Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    J Chin Med Assoc 71:286-93. 2008
    ....
  19. doi request reprint A phase II randomized trial of gefitinib alone or with tegafur/uracil treatment in patients with pulmonary adenocarcinoma who had failed previous chemotherapy
    Yuh Min Chen
    Chest Department, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China
    J Thorac Oncol 6:1110-6. 2011
    ..This study aimed to assess the efficacy of adding daily oral UFT to gefitinib treatment in patients with pulmonary adenocarcinoma who had failed previous chemotherapy...
  20. doi request reprint Third-line or fourth-line chemotherapy in non-small-cell lung cancer patients with relatively good performance status
    Yuh Min Chen
    Chest Department, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    J Chin Med Assoc 74:209-14. 2011
    ..Our aim here was to explore treatment efficacy of pemetrexed and docetaxel in non-small-cell lung cancer patients who had failed previous chemotherapy and epidermal growth factor receptor-tyrosine kinase inhibitor therapy...
  21. ncbi request reprint Restoration of cytotoxic T lymphocyte function in malignant pleural effusion: interleukin-15 vs. interleukin-2
    Y M Chen
    Chest Department, Veterans General Hospital Taipei, School of Medicine, National Yang Ming University, Taiwan
    J Interferon Cytokine Res 20:31-9. 2000
    ..The results suggest that both IL-15 and IL-2 can restore CTL activity from EAL in the presence of T cell receptor (TCR)-CD3 engagement, but the effect of IL-15 was superior...
  22. pmc A randomised phase II study of weekly paclitaxel or vinorelbine in combination with cisplatin against inoperable non-small-cell lung cancer previously untreated
    Y M Chen
    Chest Department, Taipei Veterans General Hospital, Taipei, Taiwan
    Br J Cancer 90:359-65. 2004
    ..British Journal of Cancer (2004) 90, 359-365. doi:10.1038/sj.bjc.6601526 www.bjcancer.com..
  23. ncbi request reprint Phase II study of tamoxifen, ifosfamide, epirubicin and cisplatin combination chemotherapy in patients with non-small cell lung cancer failing previous chemotherapy
    Y Chen
    Chest Department, Veterans General Hospital Taipei and School of Medicine, National Yang Ming University, Taipei, Taiwan, ROC
    Lung Cancer 29:139-46. 2000
    ..In conclusion, TIEP appears to be an active combination regimen with an acceptable toxicity profile in Chinese patients with NSCLC who have failed previous chemotherapy...
  24. ncbi request reprint Usefulness of pig-tail catheter for palliative drainage of malignant pleural effusions in cancer patients
    Y M Chen
    Chest Department, Veterans General Hospital Taipei, School of Medicine, National Yang Ming University, Taiwan, ROC
    Support Care Cancer 8:423-6. 2000
    ..Sono-guided pig-tail drainage is a safe and convenient method of effusion drainage in cancer patients. It not only provides temporary relief of symptoms from massive pleural effusions, but can also be used for pleurodesis if needed...
  25. ncbi request reprint Phase II study with gemcitabine, ifosfamide and cisplatin in advanced non-small cell lung cancer
    Y M Chen
    Chest Department, Veterans General Hospital Taipei and School of Medicine, National Yang Ming University, Taiwan, ROC
    Lung Cancer 30:199-202. 2000
    ..A randomized trial comparing GIP to a two-drug combination of gemcitabine and cisplatin is planned...
  26. ncbi request reprint Phase II study with vinorelbine and cisplatin in advanced non-small cell lung cancer after failure of previous chemotherapy
    Yuh Min Chen
    Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    J Chin Med Assoc 66:241-6. 2003
    ..We conducted a phase II study of vinorelbine and cisplatin chemotherapy in non-small cell lung cancer (NSCLC) patients who had failed previous chemotherapy, to assess the response and toxicity of this combination chemotherapy...
  27. ncbi request reprint An analysis of cytokine status in the serum and effusions of patients with tuberculous and lung cancer
    Y M Chen
    Chest Department, Veterans General Hospital Taipei, Shih Pai Road, Taipei 112, Taiwan, ROC
    Lung Cancer 31:25-30. 2001
    ....
  28. ncbi request reprint Impact of severe acute respiratory syndrome on the status of lung cancer chemotherapy patients and a correlation of the signs and symptoms
    Yuh Min Chen
    Chest Department, Taipei Veterans General Hospital, and National Yang Ming University, Shih Pai Road, Taipei 112, Taiwan
    Lung Cancer 45:39-43. 2004
    ..Its clinical manifestations overlap with the signs and symptoms of lung cancer. Thus, a clear differentiation between the two conditions is needed, especially for those patients who are under active anti-cancer treatment...
  29. ncbi request reprint A phase II trial of vinorelbine plus gemcitabine in previously untreated inoperable (stage IIIb/IV) non-small-cell lung cancer patients aged 80 or older
    Yuh Min Chen
    Chest Department, Taipei Veterans General Hospital, School of Medicine, National Yang Ming University, 201, Sec 2, Shih Pai Road, Taipei 112, Taiwan, ROC
    Lung Cancer 40:221-6. 2003
    ..In conclusion, the combination of vinorelbine and gemcitabine in very old patients with advanced NSCLC is a highly active regimen with an acceptable toxicity profile...
  30. ncbi request reprint Intrathecal gemcitabine chemotherapy for non-small cell lung cancer patients with meningeal carcinomatosis--a case report
    Yuh Min Chen
    Chest Department, Taipei Veterans General Hospital and School of Medicine, National Yang Ming University, Shih Pai Road, 112, ROC, Taipei, Taiwan
    Lung Cancer 40:99-101. 2003
    ..We herein report our experience using gemcitabine intrathecal injections in a NSCLC patient with leptomeningeal carcinomatosis...
  31. ncbi request reprint Interleukin-7 and interleukin-12 have different effects in rescue of depressed cellular immunity: comparison of malignant and tuberculous pleural effusions
    Y M Chen
    Chest Department, Taipei Veterans General Hospital, School of Medicine, National Yang Ming University, Taipei, Taiwan
    J Interferon Cytokine Res 21:249-56. 2001
    ..Both IL-7 and IL-12, in the presence of IL-2, can restore the immunosuppressed cytolytic activity of the lymphocytes of malignant pleural effusion against autologous tumor...
  32. ncbi request reprint Phase II study of docetaxel and ifosfamide combination chemotherapy in non-small-cell lung cancer patients failing previous chemotherapy with or without paclitaxel
    Yuh Min Chen
    Chest Department, Taipei Veterans General Hospital, and School of Medicine, National Yang Ming University, Shih Pai Road, Taipei 112, Taiwan, ROC
    Lung Cancer 39:209-14. 2003
    ..Physicians should be alert to the potential of interstitial pneumonitis. Nevertheless, median survival was of a reasonable duration...
  33. ncbi request reprint Paclitaxel plus carboplatin, compared with paclitaxel plus gemcitabine, shows similar efficacy while more cost-effective: a randomized phase II study of combination chemotherapy against inoperable non-small-cell lung cancer previously untreated
    Y M Chen
    Chest Department, Taipei Veterans General Hospital, National Yang Ming University, National Health Research Institute, Taiwan
    Ann Oncol 13:108-15. 2002
    ..Our aim here was to evaluate the clinical efficacy and cost-effectiveness of PC versus PG in chemo-naive. advanced NSCLC patients...
  34. ncbi request reprint Double signal stimulation was required for full recovery of the autologous tumor-killing effect of effusion-associated lymphocytes
    Yuh Min Chen
    Chest Department, Taipei Veterans General Hospital, 201, Sec 2 Shih Pai Road, Taipei, Taiwan, ROC
    Chest 122:1421-7. 2002
    ..To determine the different effects of interleukin (IL)-2, IL-4, IL-7, IL-10, IL-12, and/or T-cell receptor (TCR)-CD3 engagement in recovering the functions of cytotoxic T lymphocytes (CTL) from malignant effusion...
  35. ncbi request reprint Salvage therapy for Chinese non-small cell lung cancer patients who failed previous chemotherapy
    Yuh Min Chen
    Chest Department, Taipei Veterans General Hospital, School of Medicine, National Yang Ming University, Taipei, Taiwan
    J Thorac Oncol 1:545-50. 2006
    ..However, gefitinib has a better safety profile and probably better survival than the chemotherapeutic agents and would be an appropriate alternative choice for salvage chemotherapy, even in a second-line setting for Chinese patients...
  36. doi request reprint Second-line therapy for elderly patients with non-small cell lung cancer who failed previous chemotherapy is as effective as for younger patients
    Chieh Hung Wu
    Chest Department, Taipei Veterans General Hospital, School of Medicine, National Yang Ming University, Taipei, Taiwan, Republic of China
    J Thorac Oncol 5:376-9. 2010
    ..Whether epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) is more favorable than chemotherapeutic agents as a salvage therapy agent in elderly patients with NSCLC is also undetermined...
  37. doi request reprint ATM polymorphisms and risk of lung cancer among never smokers
    Yen Li Lo
    Institute of Population Health Sciences, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 350, Taiwan
    Lung Cancer 69:148-54. 2010
    ..This study suggests support to the literature that ATM polymorphisms and environmental tobacco smoke exposure have a role in lung carcinogenesis among never smokers...
  38. ncbi request reprint Phase II study of docetaxel and gemcitabine combination chemotherapy in non-small-cell lung cancer patients failing previous chemotherapy
    Yuh Min Chen
    Chest Department, Taipei Veterans General Hospital, and School of Medicine, National Yang Ming University, Taipei 112, Taiwan, ROC
    Am J Clin Oncol 25:509-12. 2002
    ..In conclusion, docetaxel and gemcitabine salvage chemotherapy produces a high response rate and a relatively mild toxicity profile in NSCLC. However, the issue of interstitial pneumonitis should be of concern...
  39. doi request reprint High efficacy of erlotinib in Taiwanese NSCLC patients in an expanded access program study previously treated with chemotherapy
    Reury Perng Perng
    Chest Department, Taipei Veterans General Hospital, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Lung Cancer 62:78-84. 2008
    ..An open label phase II study was conducted in Taiwanese patients with NSCLC to evaluate its efficacy...
  40. doi request reprint Polymorphisms of MLH1 and MSH2 genes and the risk of lung cancer among never smokers
    Yen Li Lo
    Institute of Population Health Sciences, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 350, Taiwan
    Lung Cancer 72:280-6. 2011
    ..This study also suggests that MLH1 -93A>G polymorphisms and ETS exposure have a role in the tumorigenesis of lung adenocarcinoma among never smokers...
  41. doi request reprint Association of an EGFR intron 1 SNP with never-smoking female lung adenocarcinoma patients
    Yuh Shan Jou
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Lung Cancer 64:251-6. 2009
    ..81, 95% CI=1.02-7.77). Together, our results suggest that polymorphisms or haplotypes of the EGFR play an important role in the development of lung cancer in Taiwan, particularly in never-smoking female lung adenocarcinoma...
  42. doi request reprint Risk factors for primary lung cancer among never smokers by gender in a matched case-control study
    Yen Li Lo
    Institute of Population Health Sciences, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 350, Taiwan
    Cancer Causes Control 24:567-76. 2013
    ..Lung cancers that occur in never smokers differ from those that occur in smokers. We performed an analysis of potential epidemiological risk factors for lung cancer among never smokers...
  43. doi request reprint Circulating interleukin-6 level is a prognostic marker for survival in advanced nonsmall cell lung cancer patients treated with chemotherapy
    Chin Hao Chang
    Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan, Republic of China
    Int J Cancer 132:1977-85. 2013
    ..Patients with high circulating IL-6 also responded poorly to chemotherapy. Therefore, a high level of circulating IL-6 was associated with an inferior response and survival outcome in NSCLC patients treated with chemotherapy...
  44. doi request reprint A polymorphism in the APE1 gene promoter is associated with lung cancer risk
    Yen Li Lo
    Division of Biostatistics and Bioinformatics, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Miaoli County 350, Taiwan
    Cancer Epidemiol Biomarkers Prev 18:223-9. 2009
    ..Together, our results suggest that polymorphisms of the APE1 gene possibly interact with smoking and may contribute to the development of lung cancer...
  45. ncbi request reprint Spectrum of cancer risk among Taiwanese with chronic obstructive pulmonary disease
    Chi Lu Chiang
    Department of Chest Medicine, Taipei Veterans General Hospital, No 201, Sec 2, Shi Pai Road, Taipei, 112, Taiwan
    Int J Clin Oncol 21:1014-1020. 2016
    ..We studied the risk of incident cancer in COPD patients using a nationwide representative database, the Taiwan National Health Insurance Research Database...
  46. ncbi request reprint Phase II randomized study of weekly docetaxel alone or plus UFUR treatment in non-small cell lung cancer patients who failed previous chemotherapy
    Kun Ta Chou
    Chest Department, Taipei Veterans General Hospital, Taipei, Taiwan
    Lung Cancer 59:64-8. 2008
    ..This study aimed to assess the feasibility and efficacy of adding UFUR (UFT, tegafur/uracil) into weekly docetaxel treatment for non-small cell lung cancer (NSCLC) patients who failed previous platinum-based chemotherapy...
  47. ncbi request reprint Phase II study of gemcitabine and vinorelbine combination chemotherapy in patients with non-small-cell lung cancer not responding to previous chemotherapy
    Yuh Min Chen
    Chest Department, Taipei Veterans General Hospital, and School of Medicine, National Yang Ming University, Taipei 112, Taiwan, ROC
    Am J Clin Oncol 26:567-70. 2003
    ..Further study is needed to confirm its activity...
  48. ncbi request reprint Mutation in the tyrosine kinase domain of epidermal growth factor receptor is a predictive and prognostic factor for gefitinib treatment in patients with non-small cell lung cancer
    Teh Ying Chou
    Department of Pathology and Chest Department, Taipei Veterans General Hospital, School of Medicine and Institute of Genetics and Genome Research Center, National Yang Ming University, Taiwan
    Clin Cancer Res 11:3750-7. 2005
    ..We investigated the association between mutations in EGFR tyrosine kinase domain and tumor response and survival in gefitinib-treated NSCLC patients...
  49. doi request reprint A prospective study of the use of circulating markers as predictors for epidermal growth factor receptor-tyrosine kinase inhibitor treatment in pulmonary adenocarcinoma
    Yung Hung Luo
    Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Cancer Biomark 16:19-29. 2016
    ..The use of liquid tissue, such as circulating cells, to predict treatment response is attracting more attention...
  50. doi request reprint Efficacy of chemotherapy in epidermal growth factor receptor (EGFR) mutated metastatic pulmonary adenocarcinoma patients who had acquired resistance to first-line EGFR tyrosine kinase inhibitor (TKI)
    Yen Han Tseng
    a Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China
    J Chemother 28:50-8. 2016
    ..However, the efficacy of salvage chemotherapy is still unknown...
  51. doi request reprint Gefitinib enhances cytotoxicities of antimicrotubule agents in non-small-cell lung cancer cells exhibiting no sensitizing epidermal growth factor receptor mutation
    Chun Ming Tsai
    Division of Thoracic Oncology, Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    J Thorac Oncol 7:1218-27. 2012
    ..The combination effects deserved to be further examined in vitro...
  52. pmc Fanconi anemia genes in lung adenocarcinoma- a pathway-wide study on cancer susceptibility
    Shi Yi Yang
    Genomics Research Center, Taipei, Taiwan
    J Biomed Sci 23:23. 2016
    ..This study is to determine whether genetic polymorphism of the FA genes is associated with an elevated risk of lung adenocarcinoma, and whether the association between genotypes and risk is modified by exposure to cigarette smoke...
  53. doi request reprint Erlotinib in patients with advanced lung squamous cell carcinoma
    Chi Lu Chiang
    Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Cancer Chemother Pharmacol 71:203-8. 2013
    ..Erlotinib had proved efficacy in patients with advanced non-small cell lung cancer, especially adenocarcinoma. The aim of this study was to evaluate the efficacy of erlotinib in patients with advanced lung squamous cell carcinoma (LSQC)...
  54. ncbi request reprint Revisit of 1997 TNM staging system--survival analysis of 1112 lung cancer patients in Taiwan
    Reury Perng Perng
    Chest Department, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan
    Jpn J Clin Oncol 37:9-15. 2007
    ..There is neither a nation-wide nor a large-scale, multi-institutional lung cancer database available for stage-by-stage survival analysis in Taiwan at present...
  55. pmc Sleep Apnea and Risk of Panic Disorder
    Vincent Yi Fong Su
    Center of Sleep Medicine, Taipei Veterans General Hospital, Taipei, Taiwan Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan School of Medicine, National Yang Ming University, Taipei, Taiwan Institute of Clinical Medicine, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Ann Fam Med 13:325-30. 2015
    ..Epidemiological studies have identified a trend in the development of depressive and anxiety disorders following a diagnosis of sleep apnea. The relationship between sleep apnea and subsequent panic disorder, however, remains unclear...
  56. doi request reprint The association between tumor epidermal growth factor receptor (EGFR) mutation and multiple primary malignancies in patients with adenocarcinoma of the lungs
    Yung Hung Luo
    Department of Chest Medicine, Taipei Veterans General Hospital, School of Medicine, National Yang Ming University Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital Center of Excellence for Cancer Research, Taipei Medical University, Taipei, Taiwan, Republic of China
    Am J Clin Oncol 38:147-51. 2015
    ..However, the nature of the association between the epidermal growth factor receptor (EGFR) mutation status and multiple primary malignancies in patients with adenocarcinoma of the lungs is not clearly understood at this time...
  57. doi request reprint The epidermal growth factor receptor-tyrosine kinase inhibitor era has changed the causes of death of patients with advanced non-small-cell lung cancer
    Wen Shuo Wu
    Department of Chest Medicine, Taipei Veterans General Hospital, National Yang Ming University School of Medicine, Taipei, Taiwan, ROC
    J Chin Med Assoc 76:682-5. 2013
    ..The objective of this retrospective study was to compare the causes of death in patients with a known tumor EGFR mutation status who had been treated with EGFR-TKIs...
  58. doi request reprint Genetic polymorphism of XRCC1 Arg399Gln is associated with survival in non-small-cell lung cancer patients treated with gemcitabine/platinum
    Wei Yu Liao
    Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    J Thorac Oncol 7:973-81. 2012
    ....
  59. ncbi request reprint Gefitinib is active in patients with brain metastases from non-small cell lung cancer and response is related to skin toxicity
    Chao Hua Chiu
    Chest Department, Taipei Veterans General Hospital, No 201 Section 2, Shih Pai Road, Taipei 112, Taiwan, ROC
    Lung Cancer 47:129-38. 2005
    ..It is feasible to conduct randomized trials to identify the role of gefitinib alone or in combination with other modality for treatment of NSCLC patients who have metastatic brain lesion(s)...
  60. ncbi request reprint Serum tumor markers as predictors for survival in advanced non-small cell lung cancer patients treated with gefitinib
    Chao Hua Chiu
    Section of Thoracic Oncology, Chest Department, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    Lung Cancer 57:213-21. 2007
    ..Though the imaging-based response (IBR) is the most frequently used index of the therapeutic effect in cancer patients, an index based on serum tumor markers might prove to be useful, especially in patients without measurable tumors...
  61. doi request reprint Antagonism between gefitinib and cisplatin in non-small cell lung cancer cells: why randomized trials failed?
    Chun Ming Tsai
    Section of Thoracic Oncology, Chest Department, Taipei Veterans General Hospital, Taipei, Taiwan
    J Thorac Oncol 6:559-68. 2011
    ..The mechanism of these failures was examined...
  62. doi request reprint Association between tumor epidermal growth factor receptor mutation and pulmonary tuberculosis in patients with adenocarcinoma of the lungs
    Yung Hung Luo
    Chest Department, Taipei Veterans General Hospital, School of Medicine, National Yang Ming University, Taipei, Taiwan, Republic of China
    J Thorac Oncol 7:299-305. 2012
    ..However, the association between epidermal growth factor receptor (EGFR) mutation status and pulmonary TB in patients with adenocarcinoma of the lungs is unknown...
  63. doi request reprint Sleep apnea and risk of deep vein thrombosis: a non-randomized, pair-matched cohort study
    Kun Ta Chou
    Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan
    Am J Med 125:374-80. 2012
    ..Our study strived to explore the relationship of sleep apnea and the subsequent development of DVT using a nationwide, population-based database...
  64. pmc Adjuvant Therapy for Thymic Carcinoma--A Decade of Experience in a Taiwan National Teaching Hospital
    Yen Han Tseng
    Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China
    PLoS ONE 11:e0146609. 2016
    ..The role of adjuvant treatment after surgery is unknown because of limited available data. The present study evaluated the efficacy of post-surgery adjuvant chemotherapy or radiotherapy in patients with thymic carcinoma...
  65. doi request reprint Amyloidosis and the risk of cancer: a nationwide population-based study
    Vincent Yi Fong Su
    Department of Chest Medicine, Taipei Veterans General Hospital, No 201, Sec 2, Shih Pai Road, Taipei, 112, Taiwan
    Int J Clin Oncol 20:1244-51. 2015
    ..The association between amyloidosis and cancer remains unclear...
  66. pmc Sleep disorders and increased risk of autoimmune diseases in individuals without sleep apnea
    Yi Han Hsiao
    Center of Sleep Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Sleep 38:581-6. 2015
    ..To explore the association between the non-apnea sleep disorder (NSD) and autoimmune diseases...
  67. doi request reprint Hospital outcomes for patients with stage III and IV lung cancer admitted to the intensive care unit for sepsis-related acute respiratory failure
    Kun Ta Chou
    Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    J Palliat Med 15:1234-9. 2012
    ..However, not all cancer patients would benefit from aggressive care, especially those with late-stage cancer...
  68. doi request reprint EGFR exon 19 in-frame deletion and polymorphisms of DNA repair genes in never-smoking female lung adenocarcinoma patients
    Shi Yi Yang
    Genomics Research Center, Academia Sinica, Taiwan
    Int J Cancer 132:449-58. 2013
    ..002 for trend). Our findings suggest that the in-frame deletion in EGFR exon 19 is associated with polymorphisms in DNA repair and detoxification metabolism genes in never-smoking lung adenocarcinoma patients, especially in females...
  69. doi request reprint Sleep apnea and risk of retinal vein occlusion: a nationwide population-based study of Taiwanese
    Kun Ta Chou
    Department of Chest, Taipei Veterans General Hospital, Taipei, Taiwan
    Am J Ophthalmol 154:200-205.e1. 2012
    ..To explore the relationship of sleep apnea and the subsequent development of retinal vein occlusion (RVO)...
  70. doi request reprint Sleep apnoea patients have higher mortality when confronting sepsis
    Chien Yu Huang
    Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan Department of Medicine, Taipei Hospital, Ministry of Health and Welfare, Taipei, Taiwan
    Eur J Clin Invest 44:38-45. 2014
    ..This case-control study aimed to compare the outcomes of sepsis patients with and without sleep apnoea...
  71. doi request reprint EGFR L858R mutation and polymorphisms of genes related to estrogen biosynthesis and metabolism in never-smoking female lung adenocarcinoma patients
    Shi Yi Yang
    Genomics Research Center, College of Public Health, National Taiwan University, Taipei, Taiwan
    Clin Cancer Res 17:2149-58. 2011
    ..To assess whether polymorphisms of genes related to estrogen biosynthesis and metabolism are associated with EGFR mutations...
  72. ncbi request reprint Adenocarcinoma of the lung presenting as a mycetoma with an air crescent sign
    Lan Fu Wang
    Chest Department, Taipei Veterans General Hospital, 201 Section 2, Shih Pai Rd, Taipei 112, Taiwan, Republic of China
    Chest 131:1239-42. 2007
    ..Thus, even though the chest radiograph and chest CT scan showed a typical air-crescent sign (ie, mass inside a cavity) favoring a mycetoma, the physician should still keep in mind that lung cancer may also unusually present in this way...
  73. doi request reprint Sleep apnea and risk of peptic ulcer bleeding: a nationwide population-based study
    Tsu Hui Shiao
    Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Am J Med 126:249-55, 255.e1. 2013
    ..These insults may contribute to initiation or progression of peptic ulcers. This retrospective matched-control cohort study explored the relationship of sleep apnea and subsequent development of peptic ulcer bleeding...
  74. doi request reprint The minimum period of polysomnography required to confirm a diagnosis of severe obstructive sleep apnoea
    Kun Ta Chou
    Chest Department, Taipei Veterans General Hospital, Taipei Institute of Clinical Medicine Faculty of Medicine, School of Medicine Institute of Emergency and Critical Care Medicine, National Yang Ming University, Taipei, Taiwan
    Respirology 16:1096-102. 2011
    ..However, the diagnostic validity of partial-night PSG is uncertain. This study aimed to test the validity of partial-night PSG and to determine the optimum AHI cut-off points...
  75. ncbi request reprint Lung cancer may develop subsequently or coincidently with pulmonary alveolar proteinosis
    Kang Cheng Su
    Chest Department, Taipei Veterans General Hospital, No 201, Sec 2, Shih Pai Road, Taipei 112, Taiwan
    Lung Cancer 58:144-8. 2007
    ..In conclusion, PAP can occur prior to or coincidently with lung cancer...
  76. ncbi request reprint Chromosomal aberrations of malignant pleural effusions of lung adenocarcinoma: different cytogenetic changes are correlated with genders and smoking habits
    Chueh Chuan Yen
    Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Lung Cancer 57:292-301. 2007
    ..The role of LDHC in the carcinogenesis of smoking-related lung adenocarcinoma, especially in male patients with pleural effusions, deserves further investigations...
  77. doi request reprint Bone scan flare phenomenon in non-small-cell lung cancer patients treated with gefitinib
    Heng Sheng Chao
    Zhongxing Branch, Taipei City Hospital, and Department of Medicine, School of Medicine, National Yang Ming University, Taipei, Taiwan, Republic of China
    Clin Nucl Med 34:346-9. 2009
    ..The aim of this study was to determine whether flare phenomenon occurs in non-small-cell lung cancer patients, especially adenocarcinoma in East-Asians, who respond dramatically and promptly to gefitinib...
  78. doi request reprint Symptomatic ocular metastases in lung cancer
    Hsuan Tsung Su
    Chest Department, Taipei Veterans General Hospital, Taipei, Taiwan
    Respirology 13:303-5. 2008
    ..A survey was carried out of ocular manifestations of lung cancer...
  79. ncbi request reprint Multiple primary malignancies involving lung cancer-clinical characteristics and prognosis
    Yung Yang Liu
    Chest Department, Veterans General Hospital Taipei, 201, Section 2 Shih Pai Road, Taipei, Taiwan, ROC
    Lung Cancer 35:189-94. 2002
    ..The staging status and median survival of patients who had a second primary lung cancer were better than in the general lung cancer population. Careful follow-up and intensive treatment is suggested for these patients...
  80. doi request reprint Asthma and risk of erectile dysfunction--a nationwide population-based study
    Kun Ta Chou
    Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan
    J Sex Med 8:1754-60. 2011
    ..Asthma is also a chronic inflammatory airway disorder, eliciting a low-grade systemic inflammation; however, the influence of asthma on ED has not been investigated...
  81. doi request reprint Interactive effect of cigarette smoking with human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) polymorphisms on the risk of lung cancer: a case-control study in Taiwan
    Chin Hao Chang
    Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan, Republic of China
    Am J Epidemiol 170:695-702. 2009
    ..The authors conclude that there was a noticeable modifying effect on the association between hOGG1 genotype and lung cancer risk by cigarette smoking status...
  82. doi request reprint Perceived barriers to physical activity among older adults residing in long-term care institutions
    Yuh Min Chen
    China Medical University, School of Nursing, Taichung, Taiwan, ROC
    J Clin Nurs 19:432-9. 2010
    ..This study explored barriers that older residents of long-term care (LTC) institutions experience in regular physical activity participation...
  83. doi request reprint Development and psychometric testing of the Cancer Knowledge Scale for Elders
    Ching Ching Su
    Chung Jen College of Nursing, Health Science and Management, Chia Ti City, Taiwan, ROC
    J Clin Nurs 18:700-7. 2009
    ..To develop the Cancer Knowledge Scale for Elders and test its validity and reliability...
  84. ncbi request reprint Dural metastasis in patients with malignant neoplasm and chronic subdural hematoma
    S H Tseng
    Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Acta Neurol Scand 108:43-6. 2003
    ..In this study, biopsy of the dura and cytological examination of the subdural hematoma was performed for patients with malignant neoplasm and chronic subdural hematoma to investigate the association of dural metastasis and CSH...
  85. ncbi request reprint Incidence of JC viruria is higher than that of BK viruria in Taiwan
    R T Tsai
    Department of Medicine, Chung Shun Medical and Dental College, Taiwan, Republic of China
    J Med Virol 52:253-7. 1997
    ..The prevalence of JCV appears to be higher than that of BKV in Taiwan. In addition, CY and TW-1 are the predominant subtypes of JCV prevalent in the Taiwanese population...
  86. ncbi request reprint Lung cancer associated with rheumatoid arthritis does not shorten life expectancy
    Cheng Yu Chen
    Chest Department, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    J Chin Med Assoc 68:216-20. 2005
    ..The incidence of lung cancer (LC) is reported to be higher in patients with rheumatoid arthritis (RA). The present study investigated whether or not RA altered the clinical manifestation of LC...
  87. ncbi request reprint Phase II randomized trial of tri-weekly versus days 1 and 8 weekly docetaxel as a second-line treatment of advanced non-small cell lung cancer
    Chun Liang Lai
    Pulmonary Section, Department of Internal Medicine, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan
    Jpn J Clin Oncol 35:700-6. 2005
    ..Under such doses, there were no comparative data between classic tri-weekly and Days 1 and 8 weekly schedules...