Yau Sheng Tsai

Summary

Affiliation: National Cheng Kung University
Country: Taiwan

Publications

  1. pmc ENU mutagenesis identifies mice with morbid obesity and severe hyperinsulinemia caused by a novel mutation in leptin
    Chen Jee Hong
    Institute of Brain Science, School of Medicine, National Yang Ming University, Taipei, Taiwan
    PLoS ONE 5:e15333. 2010
  2. pmc Decreased PPAR gamma expression compromises perigonadal-specific fat deposition and insulin sensitivity
    Yau Sheng Tsai
    Institute of Clinical Medicine, National Cheng Kung University, Tainan 701, Taiwan, Republic of China
    Mol Endocrinol 23:1787-98. 2009
  3. pmc Overweight worsens apoptosis, neuroinflammation and blood-brain barrier damage after hypoxic ischemia in neonatal brain through JNK hyperactivation
    Yi Fang Tu
    Institute of Clinical Medicine, National Cheng Kung University College of Medicine, Tainan, Taiwan
    J Neuroinflammation 8:40. 2011
  4. pmc Vitamin D can ameliorate chlorhexidine gluconate-induced peritoneal fibrosis and functional deterioration through the inhibition of epithelial-to-mesenchymal transition of mesothelial cells
    Yi Che Lee
    Division of Nephrology, Department of Internal Medicine, E Da Hospital, I Shou University, Kaohsiung, Taiwan Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan
    Biomed Res Int 2015:595030. 2015
  5. doi request reprint Egr-1 deficiency protects from renal inflammation and fibrosis
    Li chun Ho
    Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China
    J Mol Med (Berl) 94:933-42. 2016
  6. pmc Diuretics prevent thiazolidinedione-induced cardiac hypertrophy without compromising insulin-sensitizing effects in mice
    Cherng Shyang Chang
    Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan Cardiovascular Research Center, National Cheng Kung University, Tainan, Taiwan
    Am J Pathol 184:442-53. 2014
  7. pmc Quantitative PPARγ expression affects the balance between tolerance and immunity
    Ya hui Liu
    Institute of Basic Medical Sciences, National Cheng Kung University, Tainan 70101, Taiwan
    Sci Rep 6:26646. 2016
  8. pmc Albumin stimulates renal tubular inflammation through an HSP70-TLR4 axis in mice with early diabetic nephropathy
    Huei Fen Jheng
    Institute of Basic Medical Sciences, National Cheng Kung University, Tainan 701, Taiwan Institute of Clinical Medicine, National Cheng Kung University, Tainan 701, Taiwan
    Dis Model Mech 8:1311-21. 2015
  9. doi request reprint Loss of Egr-1 sensitizes pancreatic β-cells to palmitate-induced ER stress and apoptosis
    Mun Wai Cheong
    Department of Physiology, National Cheng Kung University, 1 University Rd, Tainan 701, Taiwan, Republic of China
    J Mol Med (Berl) 93:807-18. 2015
  10. pmc Effects of PPARγ and RBP4 gene variants on metabolic syndrome in HIV-infected patients with anti-retroviral therapy
    Yuan Pin Hung
    Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan
    PLoS ONE 7:e49102. 2012

Collaborators

  • Nobuyo Maeda
  • Yuan Yow Chiou
  • Yi Heng Li
  • Wei Chuan Tsai
  • Lee Ming Chuang
  • Shih Jen Tsai
  • Po Hsiu Kuo
  • Y Eugene Chen
  • Jun Yang Liou
  • Kenneth K Wu
  • Hyung Suk Kim
  • Chen Jee Hong
  • Tsun Mei Lin
  • Pei Jane Tsai
  • Li chun Ho
  • Ju Yi Chen
  • Huei Fen Jheng
  • Junne Ming Sung
  • Haw Chih Tai
  • Yi Che Lee
  • Sheng Hsiang Lin
  • Cherng Shyang Chang
  • Jun Neng Roan
  • Shih Chieh Lin
  • Ya hui Liu
  • Yi Ting Shen
  • Shun Hua Chen
  • Wen Chung Chen
  • Chen Fuh Lam
  • Chao Chun Yang
  • Ming Long Yeh
  • Mun Wai Cheong
  • Shih Yuan Hung
  • Hsi Hao Wang
  • Min Yu Chang
  • Hung Hsiang Liou
  • Hua Lin Wu
  • Hao Kuang Wang
  • Hsin Pao Chen
  • Kuang Wen Liu
  • Ming Jer Tang
  • Li Hua Kuo
  • Chang Hua Chou
  • Yuan Pin Hung
  • Yi Fang Tu
  • Jui Sheng Wu
  • Chwan Yau Luo
  • Chi Ju Lee
  • Han Ni Cheng
  • Chao Chung Young
  • Chung Tiang Liang
  • Shih Hua Teng
  • Nan Shih Liao
  • Alice Y W Chang
  • Kuan Chieh Wang
  • Chao Han Lai
  • Shih Wen Hsu
  • Meei Jyh Jiang
  • Ming Shiou Jan
  • Ting An Tai
  • Yi Lun Chuang
  • Kuei Tai A Lai
  • Chu Hung Tsai
  • Lynn L H Huang
  • Michael W Hughes
  • Kuan Min She
  • Chuan Kai Chou
  • Chi Wei Lin
  • Yi Ning Cheng
  • Chung Hsing Chang
  • Tai Lan Tuan
  • Chih I Chen
  • Pei Lun Chung
  • Yan Shen Shan
  • Hamm Ming Sheu
  • Wen Tai Chiu
  • Pei Jung Lu
  • Ho Ching Chen
  • Ching Fang Wu
  • Kumar Pandya
  • Hong Arh Fan
  • Yung Tang Kung
  • Hsiang Chun Liu
  • Yu Tzu Chang
  • Li Jen Lin
  • Shu Chu Shiesh
  • Mei Chung Wang
  • Ruei Lan Tsai
  • Ming Cheng Wang
  • Nan Yao Lee

Detail Information

Publications19

  1. pmc ENU mutagenesis identifies mice with morbid obesity and severe hyperinsulinemia caused by a novel mutation in leptin
    Chen Jee Hong
    Institute of Brain Science, School of Medicine, National Yang Ming University, Taipei, Taiwan
    PLoS ONE 5:e15333. 2010
    ..Obesity is a multifactorial disease that arises from complex interactions between genetic predisposition and environmental factors. Leptin is central to the regulation of energy metabolism and control of body weight in mammals...
  2. pmc Decreased PPAR gamma expression compromises perigonadal-specific fat deposition and insulin sensitivity
    Yau Sheng Tsai
    Institute of Clinical Medicine, National Cheng Kung University, Tainan 701, Taiwan, Republic of China
    Mol Endocrinol 23:1787-98. 2009
    ..Together, these results underscore the differential sensitivity of the individual fat depots on PPAR gamma availability as an underlying mechanism of partial lipodystrophy...
  3. pmc Overweight worsens apoptosis, neuroinflammation and blood-brain barrier damage after hypoxic ischemia in neonatal brain through JNK hyperactivation
    Yi Fang Tu
    Institute of Clinical Medicine, National Cheng Kung University College of Medicine, Tainan, Taiwan
    J Neuroinflammation 8:40. 2011
    ..We hypothesized that neonatal overweight aggravates HI brain damage through JNK hyperactivation-mediated upregulation of neuronal apoptosis, neuroinflammation and BBB leakage in rat pups...
  4. pmc Vitamin D can ameliorate chlorhexidine gluconate-induced peritoneal fibrosis and functional deterioration through the inhibition of epithelial-to-mesenchymal transition of mesothelial cells
    Yi Che Lee
    Division of Nephrology, Department of Internal Medicine, E Da Hospital, I Shou University, Kaohsiung, Taiwan Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan
    Biomed Res Int 2015:595030. 2015
    ..Vitamin D can ameliorate these negative effects; however, the mechanism remains unexplored. Therefore, we investigated its possible links to MCs EMT inhibition...
  5. doi request reprint Egr-1 deficiency protects from renal inflammation and fibrosis
    Li chun Ho
    Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China
    J Mol Med (Berl) 94:933-42. 2016
    ..Our study highlights the integrative role of Egr-1 in renal inflammation and fibrosis. Thus, Egr-1 may serve as a therapeutic target for human kidney diseases...
  6. pmc Diuretics prevent thiazolidinedione-induced cardiac hypertrophy without compromising insulin-sensitizing effects in mice
    Cherng Shyang Chang
    Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan Cardiovascular Research Center, National Cheng Kung University, Tainan, Taiwan
    Am J Pathol 184:442-53. 2014
    ..We conclude that releasing plasma volume reduces adverse effects of TZD-induced volume expansion and cardiac events without compromising TZD actions in metabolic switch in the heart and whole-body insulin sensitivity. ..
  7. pmc Quantitative PPARγ expression affects the balance between tolerance and immunity
    Ya hui Liu
    Institute of Basic Medical Sciences, National Cheng Kung University, Tainan 70101, Taiwan
    Sci Rep 6:26646. 2016
    ....
  8. pmc Albumin stimulates renal tubular inflammation through an HSP70-TLR4 axis in mice with early diabetic nephropathy
    Huei Fen Jheng
    Institute of Basic Medical Sciences, National Cheng Kung University, Tainan 701, Taiwan Institute of Clinical Medicine, National Cheng Kung University, Tainan 701, Taiwan
    Dis Model Mech 8:1311-21. 2015
    ....
  9. doi request reprint Loss of Egr-1 sensitizes pancreatic β-cells to palmitate-induced ER stress and apoptosis
    Mun Wai Cheong
    Department of Physiology, National Cheng Kung University, 1 University Rd, Tainan 701, Taiwan, Republic of China
    J Mol Med (Berl) 93:807-18. 2015
    ..Our study underscores Egr-1 as a critical early sensor in pancreatic β-cells to translate fatty acid stimuli into a cellular adaptation mechanism...
  10. pmc Effects of PPARγ and RBP4 gene variants on metabolic syndrome in HIV-infected patients with anti-retroviral therapy
    Yuan Pin Hung
    Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan
    PLoS ONE 7:e49102. 2012
    ..The influences of PPARγ (C1431T and Pro12Ala) and RBP4 (-803GA) polymorphisms on metabolic syndrome in HIV-infected patients receiving anti-retroviral therapy were examined in this study...
  11. doi request reprint Increased aortic stiffness and attenuated lysyl oxidase activity in obesity
    Ju Yi Chen
    Institute of Clinical Medicine, National Cheng Kung University, Tainan 701, Taiwan
    Arterioscler Thromb Vasc Biol 33:839-46. 2013
    ..The aim of this study was to investigate the pathophysiology that links obesity to aortic stiffening...
  12. doi request reprint Exendin-4, a glucagon-like peptide-1 analogue, accelerates diabetic wound healing
    Jun Neng Roan
    Institute of Clinical Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan Division of Cardiovascular Surgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    J Surg Res 208:93-103. 2017
    ..The therapeutic potential of a Glp-1 analogue in a diabetic rat model of excisional wound injury was investigated...
  13. pmc Peroxisome Proliferator-Activated Receptor γ Level Contributes to Structural Integrity and Component Production of Elastic Fibers in the Aorta
    Haw Chih Tai
    From the Institute of Clinical Medicine H C T, J Y C, C H L, Y S T, Cardiovascular Research Center H C T, J Y C, C H L, K C W, M J J, Y H L, H L W, Y S T, Departments of Medical Laboratory Science and Biotechnology P J T, Biochemistry and Molecular Biology K C W, H L W, Physiology S C L, A Y W C, Cell Biology and Anatomy M J J, National Cheng Kung University, Tainan, Taiwan, Republic of China Departments of Internal Medicine J Y C, Y H L, Surgery C H L, and Research Center of Clinical Medicine Y S T, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China Graduate Institute of Biomedical Sciences, Chang Gung University, Taoyuan, Taiwan, Republic of China S H T and Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill N M
    Hypertension 67:1298-308. 2016
    ..Our results underscore the importance of PPARγ in AAA development though orchestrating proper elastogenesis and preserving elastic fiber integrity. ..
  14. pmc Shorter daily dwelling time in peritoneal dialysis attenuates the epithelial-to-mesenchymal transition of mesothelial cells
    Yi Che Lee
    Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan
    BMC Nephrol 15:35. 2014
    ..The epithelial-to-mesenchymal transition (EMT) of mesothelial cells (MCs) plays an important role during the above process; however, the clinical parameters associated with the EMT process of MCs remain to be explored...
  15. doi request reprint Polymorphisms of INSIG2, MC4R, and LEP are associated with obesity- and metabolic-related traits in schizophrenic patients
    Po Hsiu Kuo
    Department of Public Health and Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan
    J Clin Psychopharmacol 31:705-11. 2011
    ..We aimed to investigate the associations between these genes and metabolic disturbances in patients with schizophrenia in Taiwan...
  16. doi request reprint Leptin of dermal adipose tissue is differentially expressed during the hair cycle and contributes to adipocyte-mediated growth inhibition of anagen-phase vibrissa hair
    Chao Chun Yang
    Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan International Research Center of Wound Repair and Regeneration, National Cheng Kung University, Tainan, Taiwan
    Exp Dermatol 24:57-60. 2015
    ..Our data suggest that leptin of dermal white adipose tissue might regulate hair growth and, therefore, hair cycle progression via leptin receptor on the hair follicle epithelium. ..
  17. pmc Mitochondrial fission contributes to mitochondrial dysfunction and insulin resistance in skeletal muscle
    Huei Fen Jheng
    Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Republic of China
    Mol Cell Biol 32:309-19. 2012
    ..Thus, disruption of mitochondrial dynamics may underlie the pathogenesis of muscle insulin resistance in obesity and type 2 diabetes...
  18. pmc Ligand-activated peroxisome proliferator-activated receptor-gamma protects against ischemic cerebral infarction and neuronal apoptosis by 14-3-3 epsilon upregulation
    Jui Sheng Wu
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Circulation 119:1124-34. 2009
    ..Their protective actions are considered to be peroxisome proliferator-activated receptor-gamma (PPAR-gamma)-dependent; however, it is unclear how PPAR-gamma activation confers resistance to ischemia-reperfusion injury...
  19. doi request reprint Effects of increased systemic inflammation and central obesity on arterial stiffness in patients with nonalcoholic fatty liver disease
    Ju Yi Chen
    Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    J Am Soc Hypertens 6:253-60. 2012
    ..01-1.13; P < .05) was the only independent factor that predicted low CI (<median value) in patients with NAFLD. Central obesity was an important determinant both for increased arterial stiffness and hs-CRP in Patients with NAFLD...