Wu Chou Su

Summary

Affiliation: National Cheng Kung University
Country: Taiwan

Publications

  1. ncbi request reprint Comparison of in vitro growth-inhibitory activity of carboplatin and cisplatin on leukemic cells and hematopoietic progenitors: the myelosuppressive activity of carboplatin may be greater than its antileukemic effect
    W C Su
    Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan
    Jpn J Clin Oncol 30:562-7. 2000
  2. pmc Constitutive activation of STAT3 and STAT5 is present in the majority of nasopharyngeal carcinoma and correlates with better prognosis
    J R Hsiao
    Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, 1 Doshiue Road, Tainan 701, Taiwan
    Br J Cancer 89:344-9. 2003
  3. ncbi request reprint Combined intrapleural and intravenous chemotherapy, and pulmonary irradiation, for treatment of patients with lung cancer presenting with malignant pleural effusion. A pilot study
    Wu Chou Su
    Department of Internal Medicine, National Cheng Kung University, Tainan, Taiwan
    Oncology 64:18-24. 2003
  4. ncbi request reprint Expression of S100A4 and Met: potential predictors for metastasis and survival in early-stage breast cancer
    Wen Ying Lee
    Department of Pathology, National Cheng Kung University Hospital, Tainan, Taiwan
    Oncology 66:429-38. 2004
  5. doi request reprint Metformin enhances cisplatin cytotoxicity by suppressing signal transducer and activator of transcription-3 activity independently of the liver kinase B1-AMP-activated protein kinase pathway
    Chien Chung Lin
    Institute of Clinical Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Am J Respir Cell Mol Biol 49:241-50. 2013
  6. doi request reprint Mitochondrial uncoupling protein 2 regulates the effects of paclitaxel on Stat3 activation and cellular survival in lung cancer cells
    Wen Pin Su
    Graduate Institute of Clinical Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, No 35, Xiao dong Rd, Tainan 704, Taiwan
    Carcinogenesis 33:2065-75. 2012
  7. doi request reprint Single cell phospho-specific flow cytometry can detect dynamic changes of phospho-Stat1 level in lung cancer cells
    Chien Chung Lin
    Graduate Institute of Clinical Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Taiwan
    Cytometry A 77:1008-19. 2010
  8. doi request reprint Activation of the signal transducer and activator of transcription 3 pathway up-regulates estrogen receptor-beta expression in lung adenocarcinoma cells
    Hao Chen Wang
    Institute of Basic Medical Sciences, National Cheng Kung University, Medical College, Tainan, Taiwan, Republic of China
    Mol Endocrinol 25:1145-58. 2011
  9. pmc Pronounced induction of endoplasmic reticulum stress and tumor suppression by surfactant-free poly(lactic-co-glycolic acid) nanoparticles via modulation of the PI3K signaling pathway
    Chia Cheng Hou
    Institute of Basic Medical Sciences, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Int J Nanomedicine 8:2689-707. 2013
  10. doi request reprint EGFR polymorphisms, hormone replacement therapy and lung adenocarcinoma risk: analysis from a genome-wide association study in never-smoking women
    Kuan Yu Chen
    Division of Pulmonary Medicine, Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei 100, Taiwan
    Carcinogenesis 34:612-9. 2013

Detail Information

Publications81

  1. ncbi request reprint Comparison of in vitro growth-inhibitory activity of carboplatin and cisplatin on leukemic cells and hematopoietic progenitors: the myelosuppressive activity of carboplatin may be greater than its antileukemic effect
    W C Su
    Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan
    Jpn J Clin Oncol 30:562-7. 2000
    ..The study was designed to elucidate whether their myelosuppressive activities equal their antileukemic effects...
  2. pmc Constitutive activation of STAT3 and STAT5 is present in the majority of nasopharyngeal carcinoma and correlates with better prognosis
    J R Hsiao
    Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, 1 Doshiue Road, Tainan 701, Taiwan
    Br J Cancer 89:344-9. 2003
    ..To our knowledge, this is the first report providing the overall expression patterns and prognostic significance of specific STATs in NPC...
  3. ncbi request reprint Combined intrapleural and intravenous chemotherapy, and pulmonary irradiation, for treatment of patients with lung cancer presenting with malignant pleural effusion. A pilot study
    Wu Chou Su
    Department of Internal Medicine, National Cheng Kung University, Tainan, Taiwan
    Oncology 64:18-24. 2003
    ..In this pilot study, we designed a protocol of combined intrapleural (i.p.) and intravenous (i.v.) chemotherapy and pulmonary irradiation to enhance local as well as systemic control of the disease...
  4. ncbi request reprint Expression of S100A4 and Met: potential predictors for metastasis and survival in early-stage breast cancer
    Wen Ying Lee
    Department of Pathology, National Cheng Kung University Hospital, Tainan, Taiwan
    Oncology 66:429-38. 2004
    ..To formulate individually tailored therapy for patients with early-stage breast cancer, it is necessary to identify biomarkers for predicting metastasis and survival...
  5. doi request reprint Metformin enhances cisplatin cytotoxicity by suppressing signal transducer and activator of transcription-3 activity independently of the liver kinase B1-AMP-activated protein kinase pathway
    Chien Chung Lin
    Institute of Clinical Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Am J Respir Cell Mol Biol 49:241-50. 2013
    ..Thus, metformin helps to overcome tumor drug resistance by targeting STAT3. ..
  6. doi request reprint Mitochondrial uncoupling protein 2 regulates the effects of paclitaxel on Stat3 activation and cellular survival in lung cancer cells
    Wen Pin Su
    Graduate Institute of Clinical Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, No 35, Xiao dong Rd, Tainan 704, Taiwan
    Carcinogenesis 33:2065-75. 2012
    ..Therefore, UCP-2 modulates the ROS/Stat3 signaling pathway and response to chemotherapy treatment in lung cancer cells. Targeting UCP-2, ROS and Stat3 pathways may improve anticancer therapies...
  7. doi request reprint Single cell phospho-specific flow cytometry can detect dynamic changes of phospho-Stat1 level in lung cancer cells
    Chien Chung Lin
    Graduate Institute of Clinical Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Taiwan
    Cytometry A 77:1008-19. 2010
    ..In conclusion, there is a preliminary application of SCPFC to solid tumors and links to drug sensitivity are promising...
  8. doi request reprint Activation of the signal transducer and activator of transcription 3 pathway up-regulates estrogen receptor-beta expression in lung adenocarcinoma cells
    Hao Chen Wang
    Institute of Basic Medical Sciences, National Cheng Kung University, Medical College, Tainan, Taiwan, Republic of China
    Mol Endocrinol 25:1145-58. 2011
    ..The findings shed light on new therapeutic targets for female lung cancer, especially for those with EGFR mutations...
  9. pmc Pronounced induction of endoplasmic reticulum stress and tumor suppression by surfactant-free poly(lactic-co-glycolic acid) nanoparticles via modulation of the PI3K signaling pathway
    Chia Cheng Hou
    Institute of Basic Medical Sciences, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Int J Nanomedicine 8:2689-707. 2013
    ..This study aimed at developing LY-loaded surfactant-free poly(lactic-co-glycolic acid) (PLGA) nanoparticles (SF-LY NPs) to improve the therapeutic efficacy of LY...
  10. doi request reprint EGFR polymorphisms, hormone replacement therapy and lung adenocarcinoma risk: analysis from a genome-wide association study in never-smoking women
    Kuan Yu Chen
    Division of Pulmonary Medicine, Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei 100, Taiwan
    Carcinogenesis 34:612-9. 2013
    ..0046, respectively). In conclusion, HRT use may modify the association of EGFR SNPs with lung adenocarcinoma risk. The EGFR SNPs have a cumulative effect on decreasing lung adenocarcinoma risk in never-smoking women with HRT use...
  11. doi request reprint Betulinic acid decreases specificity protein 1 (Sp1) level via increasing the sumoylation of sp1 to inhibit lung cancer growth
    Tsung I Hsu
    Institute of Basic Medical Sciences, College of Medicine, Institute of Bioinformatics and Biosignal Transduction, National Cheng Kung University, Tainan, Taiwan
    Mol Pharmacol 82:1115-28. 2012
    ..Taken together, the results of this study clarify the mechanism of BA-mediated Sp1 degradation and identify a pivotal role for Sp1 in the BA-induced repression of lung cancer growth...
  12. pmc Upregulation of tissue factor by activated Stat3 contributes to malignant pleural effusion generation via enhancing tumor metastasis and vascular permeability in lung adenocarcinoma
    Hsuan Heng Yeh
    Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan Cancer Center, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    PLoS ONE 8:e75287. 2013
    ..In summary, we showed that TF expression plays a pivotal role in the pathogenesis of MPE generation via regulating of tumor metastasis and vascular permeability in lung adenocarcinoma bearing activated Stat3. ..
  13. ncbi request reprint p53 and c-erbB-2 but not bcl-2 are predictive of metastasis-free survival in breast cancer patients receiving post-mastectomy adjuvant radiotherapy in Taiwan
    Helen H W Chen
    Department of Radiation Oncology, National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan
    Jpn J Clin Oncol 32:332-9. 2002
    ..We conducted a study to evaluate p53, bcl-2 and c-erbB-2 as predictors of prognosis in breast cancer patients receiving post-mastectomy radiotherapy, which has not been well defined in the Taiwanese population...
  14. ncbi request reprint Proteomic profiling of human pleural effusion using two-dimensional nano liquid chromatography tandem mass spectrometry
    Yu Chang Tyan
    Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan 704, Taiwan
    J Proteome Res 4:1274-86. 2005
    ..The significance of the use of proteomics analysis of human pleural fluid for the search of new lung cancer marker proteins, and for their simultaneous display and analysis in patients suffering from lung disorders has been examined...
  15. ncbi request reprint Clinical evaluation of HER-2/neu protein in malignant pleural effusion-associated lung adenocarcinoma and as a tumor marker in pleural effusion diagnosis
    Tsui Lien Hung
    Departments of Pathology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan
    Clin Cancer Res 9:2605-12. 2003
    ..The HER-2/neu protein expression on tumor cells was evaluated by immunohistochemical (IHC) staining, and gene amplification was assayed by fluorescence in situ hybridization...
  16. doi request reprint CDKN1A-mediated responsiveness of MLL-AF4-positive acute lymphoblastic leukemia to Aurora kinase-A inhibitors
    Ya ping Chen
    Division of Hematology Oncology, National Cheng Kung University Hospital, Tainan, Taiwan Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan Graduate Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan
    Int J Cancer 135:751-62. 2014
    ..Our study suggests CDKN1A could be a potential biomarker in determining the drug responsiveness of Aurora kinase inhibitors in ALL, particularly in MLL-AF4-positive patients. ..
  17. doi request reprint The increment in standardized uptake value determined using dual-phase 18F-FDG PET is a promising prognostic factor in non-small-cell lung cancer
    Helen H W Chen
    Department of Radiation Oncology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan 704, Taiwan
    Eur J Nucl Med Mol Imaging 40:1478-85. 2013
    ....
  18. ncbi request reprint Bone marrow that is positive for Epstein-Barr virus encoded RNA-1 by in situ hybridization is related with a poor prognosis in patients with extranodal natural killer/T-cell lymphoma, nasal type
    Wen Tsung Huang
    Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, 1 Doshiue Road, Tainan 701, Taiwan, Republic of China
    Haematologica 90:1063-9. 2005
    ..This study was done to evaluate the use of EBV-encoded RNA-1 in situ hybridization (EBER-1 ISH) to detect occult micrometastasis in the bone marrow (BM) of patients with nasal NK/T-cell lymphoma...
  19. ncbi request reprint Prognostic significance of co-expression of RON and MET receptors in node-negative breast cancer patients
    Wen Ying Lee
    Department of Pathology, College of Medicine, National Cheng Kung University, Chi Mei Medical Center, 901 Chung Hwa Road, Yung Kang City, Tainan 710, Taiwan
    Clin Cancer Res 11:2222-8. 2005
    ..We wanted to examine the clinical significance of RON and MET expression patterns in node-negative breast cancer...
  20. ncbi request reprint Emergence of YMDD mutant hepatitis B virus after allogeneic stem cell transplantation from a HBsAG-positive donor during lamivudine prophylaxis
    Yen Chien Lee
    Section of Hematology Oncology, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan
    Haematologica 89:ECR09. 2004
  21. doi request reprint STAT1 activation by venous malformations mutant Tie2-R849W antagonizes VEGF-A-mediated angiogenic response partly via reduced bFGF production
    Yi Hsien Huang
    Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC
    Angiogenesis 16:207-22. 2013
    ..A balancing activity of STAT1 and STAT3 may be important for Tie2-mediated vascular homeostasis...
  22. pmc Annexin A2 silencing induces G2 arrest of non-small cell lung cancer cells through p53-dependent and -independent mechanisms
    Chi Yun Wang
    Institute of Basic Medical Sciences, National Cheng Kung University, Tainan 701, Taiwan
    J Biol Chem 287:32512-24. 2012
    ..These results demonstrate a novel role for ANXA2 in NSCLC cell proliferation by facilitating the cell cycle partly through the regulation of p53 via JNK/c-Jun...
  23. doi request reprint Liquid biopsy genotyping in lung cancer: ready for clinical utility?
    Wei Lun Huang
    Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Oncotarget . 2017
    ..This review focuses on the clinical application of liquid biopsies to lung cancer genotyping, including EGFR and other targets of genotype-directed therapy and compares multiple platforms used for liquid biopsy...
  24. ncbi request reprint High-dose chemotherapy and hematopoietic stem cell transplantation for patients with nasopharyngeal cancer: a feasibility study
    Tsai Yun Chen
    Division of Hematology and Oncology, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan
    Jpn J Clin Oncol 33:331-5. 2003
    ..The purpose of this study was to evaluate the clinical efficacy of high-dose chemotherapy (HDCT) in combination with hematopoietic stem cell transplantation in patients with locally advanced or metastatic NPC...
  25. pmc PLGA nanoparticles codeliver paclitaxel and Stat3 siRNA to overcome cellular resistance in lung cancer cells
    Wen Pin Su
    Graduate Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, 35 Xiaodong Rd, Tainan, Taiwan
    Int J Nanomedicine 7:4269-83. 2012
    ..In this paper, poly(lactic-co-glycolic acid) (PLGA) nanoparticles loaded with paclitaxel and Stat3 siRNA were successfully synthesized, and their applications in cancer cells were investigated...
  26. ncbi request reprint Increased expression of nitric oxide synthase and cyclooxygenase-2 is associated with poor survival in cervical cancer treated with radiotherapy
    Helen H W Chen
    Department of Radiation Oncology, National Cheng Kung University Hospital, Tainan, Taiwan Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Int J Radiat Oncol Biol Phys 63:1093-100. 2005
    ..To investigate the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in cervical cancer and their association with clinical outcome in patients treated with radical radiotherapy...
  27. pmc Signal transducer and activator of transcription 3 activation up-regulates interleukin-6 autocrine production: a biochemical and genetic study of established cancer cell lines and clinical isolated human cancer cells
    Wei Lun Huang
    Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan
    Mol Cancer 9:309. 2010
    ..This study was designed to determine the role of Jak2/Stat3 pathway in the regulation of IL-6 autocrine production in cancer cells...
  28. doi request reprint Modularly assembled magnetite nanoparticles enhance in vivo targeting for magnetic resonance cancer imaging
    Ping Ching Wu
    Institute of Basic Medical Sciences and Department of Chemistry, National Cheng Kung University, Tainan 701
    Bioconjug Chem 19:1972-9. 2008
    ....
  29. doi request reprint Prognostic value of whole-body total lesion glycolysis at pretreatment FDG PET/CT in non-small cell lung cancer
    Helen H W Chen
    Department of Radiation Oncology, National Cheng Kung University, Tainan, Taiwan
    Radiology 264:559-66. 2012
    ....
  30. doi request reprint Cost effectiveness of cancer treatment in Taiwan
    Mei Chuan Hung
    Department of Public Health, National Cheng Kung University College of Medicine, Tainan, Taiwan
    J Formos Med Assoc 115:609-18. 2016
    ..This study aims to examine the cost effectiveness of treating major cancers compared with other major illnesses in Taiwan...
  31. doi request reprint Estrogen Receptor Gene Polymorphisms and Lung Adenocarcinoma Risk in Never-Smoking Women
    Kuan Yu Chen
    Division of Pulmonary Medicine, Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan Department of Medicine, School of Medicine, National Yang Ming University, Taipei, Taiwan Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital, Chiayi, Taiwan Division of Hematology Oncology, Department of Internal Medicine, National Cheng Kung University, Tainan, Taiwan Department of Chest Medicine, Taipei Veterans General Hospital, School of Medicine, National Yang Ming University, and Taipei Cancer Center, Taipei Medical University, Taipei, Taiwan Department of Internal Medicine, Kaohsiung Medical University Hospital, School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan National Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan Department of Thoracic Surgery
    J Thorac Oncol 10:1413-20. 2015
    ..The association between estrogen receptor (ER) gene polymorphism and lung cancer risk is rarely studied. This study aimed to explore the ER gene polymorphisms associated with the lung adenocarcinoma risk in never-smoking women...
  32. ncbi request reprint EBER-1 positive diffuse large cell lymphoma presenting as lupus nephritis
    Ming Hsien Lin
    Division of Nephrology, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan, ROC
    Lupus 12:486-9. 2003
    ..Serologic studies demonstrated EBV infection and specific EBV antigens were present on lymph node and metastatic sites. We offer a discussion regarding the complex relationships between SLE, NHL, MGN and EBV...
  33. pmc Nucleocytoplasmic transport blockage by SV40 peptide-modified gold nanoparticles induces cellular autophagy
    Tsung Lin Tsai
    Institute of Basic Medical Sciences, National Cheng Kung University, and Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Int J Nanomedicine 7:5215-34. 2012
    ..Taken together, the results indicate that long-term blockade of nucleocytoplasmic transport results in autophagic cell death...
  34. doi request reprint Hypoxia and metabolic phenotypes during breast carcinogenesis: expression of HIF-1alpha, GLUT1, and CAIX
    Chi long Chen
    Department of Pathology, College of Medicine, Taipei Medical University, Taipei, Taiwan
    Virchows Arch 457:53-61. 2010
    ..GLUT1 expression (glycolytic phenotype) and CAIX expression (acid-resistant phenotype) may result in a powerful adaptive advantage and represent an aggressive phenotype...
  35. ncbi request reprint Clinical response of antilymphocyte globulin-based treatment in patients in taiwan with aplastic anemia: positive hepatitis C antibody may represent a response predictor
    Yin Hsun Feng
    Division of Hematology Oncology, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan
    Int J Hematol 79:133-7. 2004
    ..In conclusion, ALG-based IS therapy was effective for aplastic anemia in Chinese patients. The role of hepatitis C associated with aplastic anemia and its relationship to IS need to be clarified by further investigations...
  36. ncbi request reprint Surfactant-assisted hollowing of Cu nanoparticles involving halide-induced corrosion-oxidation processes
    Chih Chia Huang
    Department of Chemistry and Center for Micro Nano Technology Research, National Cheng Kung University, Tainan 701, Taiwan
    Chemistry 12:3805-10. 2006
    ..4 eV for Cu2O nanoshells and 1.89 eV for CuO ellipsoids. For the contact-angle measurements, the wettability changed from hydrophilicity (18 degrees) to hydrophobicity (140 degrees) as the Cu2O nanoshells shifted to CuO ellipsoids...
  37. ncbi request reprint Water-dissolvable sodium sulfate nanowires as a versatile template for the fabrication of polyelectrolyte- and metal-based nanotubes
    Ying Chih Pu
    Department of Chemistry and Center for Micro Nano Technology Research, National Cheng Kung University, Tainan 701, Taiwan
    J Am Chem Soc 128:11606-11. 2006
    ..This unique water-dissolvable template is anticipated to bring about versatile and flexible downstream applications...
  38. pmc Positive feedback regulation between IL10 and EGFR promotes lung cancer formation
    Tsung I Hsu
    Center for Infection Disease and Signal Research, College of Medicine, Tainan, Taiwan
    Oncotarget 7:20840-54. 2016
    ..Doxycycline-induced EGFRL858R mice treated with gefitinib and anti-IL10 antibodies exhibited poor tumor formation. In conclusion, IL10 and EGFR regulate each other through positive feedback, which leads to lung cancer formation. ..
  39. pmc Epidermal Growth Factor Receptor Mutation and Anaplastic Lymphoma Kinase Gene Fusion: Detection in Malignant Pleural Effusion by RNA or PNA Analysis
    Yi Lin Chen
    Molecular Diagnostics Laboratory, Department of Pathology, National Cheng Kung University Hospital, Tainan, Taiwan
    PLoS ONE 11:e0158125. 2016
    ..Detecting ALK fusion can be incorporated in the same RNA workflow. Therefore, RNA is a better source for comprehensive molecular diagnoses in MPE. ..
  40. pmc Estimating the lifelong health impact and financial burdens of different types of lung cancer
    Szu Chun Yang
    Department of Internal Medicine, National Cheng Kung University Medical College and Hospital, 138 Sheng Li Road, Tainan 70403, Taiwan
    BMC Cancer 13:579. 2013
    ..This study attempts to quantify the quality-adjusted life expectancy (QALE), loss-of-QALE, and lifetime healthcare expenditures of patients with different pathological types of lung cancer...
  41. doi request reprint Constitutive STAT5 activation correlates with better survival in cervical cancer patients treated with radiation therapy
    Helen H W Chen
    Department of Radiation Oncology, National Cheng Kung University, Medical College and Hospital, Tainan, Taiwan
    Int J Radiat Oncol Biol Phys 82:658-66. 2012
    ..This study investigated the expression patterns of STAT1, STAT3, and STAT5 in cervical cancer and their associations with clinical outcomes in patients treated with radical radiation therapy...
  42. doi request reprint Verification of wild-type EGFR status in non-small cell lung carcinomas using a mutant-enriched PCR on selected cases
    Yi Lin Chen
    Molecular Diagnosis Laboratory, Department of Pathology, College of Medicine, National Cheng Kung University Hospital, Tainan, Taiwan Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University Hospital, Tainan, Taiwan Molecular Medicine Core Laboratory, Research Center of Clinical Medicine, College of Medicine, National Cheng Kung University Hospital, Tainan, Taiwan Associations of Medical Technologists, Tainan, Taiwan
    J Mol Diagn 16:486-94. 2014
    ..The late upward curves we observed helped identify suspicious cases for rechecking. A second method, such as PNA-sequencing, is recommended to verify wild-type cases...
  43. doi request reprint Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): a phase 2 trial
    James Chih Hsin Yang
    Graduate Institute of Oncology and Cancer Research Centre, College of Medicine, National Taiwan University, Taipei, Taiwan
    Lancet Oncol 13:539-48. 2012
    ..Afatinib is an irreversible ErbB-family blocker with preclinical activity in non-small-cell lung cancer (NSCLC) with EGFR mutations. We aimed to assess the efficacy of afatinib in patients with lung adenocarcinoma and EGFR mutations...
  44. ncbi request reprint Implantable venous port-related infections in cancer patients
    Wen Tsung Huang
    Division of Hematology Oncology, Department of Internal Medicine, National Cheng Kung University Hospital College of Medicine, 138, Sheng Li Rd, Tainan 704, Taiwan, Republic of China
    Support Care Cancer 12:197-201. 2004
    ..To evaluate the characteristics of implantable venous port-related infections in patients with malignancies...
  45. doi request reprint Ha-ras oncogene-induced Stat3 phosphorylation enhances oncogenicity of the cell
    Hsuan Heng Yeh
    Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China
    DNA Cell Biol 28:131-9. 2009
    ..The effect of Ha-ras on Stat3 phosphorylation at serine-727 was also detected in human bladder (T24) and lung (H460) cancer cells. Stat3 phosphorylation at serine-727 is important in Ras-related tumorigenesis...
  46. pmc Predictive and prognostic value of human copper transporter 1 (hCtr1) in patients with stage III non-small-cell lung cancer receiving first-line platinum-based doublet chemotherapy
    Helen H W Chen
    Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Lung Cancer 75:228-34. 2012
    ..We investigated the predictive and prognostic values of hCtr1, and copper efflux transporters ATP7A and ATP7B, in patients with locally advanced non-small cell lung cancer (NSCLC) receiving first-line platinum-based chemotherapy...
  47. doi request reprint Vinca alkaloids cause aberrant ROS-mediated JNK activation, Mcl-1 downregulation, DNA damage, mitochondrial dysfunction, and apoptosis in lung adenocarcinoma cells
    Wei Hsin Chiu
    Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Biochem Pharmacol 83:1159-71. 2012
    ..These results demonstrate an essential role of ROS in vinca alkaloid-induced aberrant JNK-mediated Mcl-1 downregulation and DNA damage followed by mitochondrial dysfunction-related apoptosis but not mitotic arrest...
  48. doi request reprint Apolipoprotein E expression promotes lung adenocarcinoma proliferation and migration and as a potential survival marker in lung cancer
    Wen Pin Su
    Graduate Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Lung Cancer 71:28-33. 2011
    ..001). Conclusively, ApoE over-expression promotes cancer proliferation and migration and contributes to an aggressive clinical course in patients with lung adenocarcinoma and MPE...
  49. doi request reprint Health-related quality of life after first-line anti-cancer treatments for advanced non-small cell lung cancer in clinical practice
    Szu Chun Yang
    Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan, 704, Taiwan
    Qual Life Res 25:1441-9. 2016
    ..This study attempted to compare changes in the Quality-of-Life (QoL) scores after three different first-line anti-cancer treatments for advanced non-small cell lung cancer (NSCLC) in a real-world clinical setting...
  50. pmc Emerging platforms using liquid biopsy to detect EGFR mutations in lung cancer
    Chien Chung Lin
    a 1 Department of Internal Medicine, Institute of Clinical Medicine, National Cheng Kung University, Hospital, College of Medicine, Tainan, Taiwan
    Expert Rev Mol Diagn 15:1427-40. 2015
    ..Recently, simpler techniques for EGFR mutant detection in urine or saliva samples have been developed. This review focuses on advances in liquid biopsy and discusses its potential for clinical implementation in lung cancer. ..
  51. pmc An increase in glucosylceramide synthase induces Bcl-xL-mediated cell survival in vinorelbine-resistant lung adenocarcinoma cells
    Wei Hsin Chiu
    Division of Hemato Oncology, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan
    Oncotarget 6:20513-24. 2015
    ..Simultaneous GCS inhibition and VNR treatment caused a decrease in Bcl-xL expression. According to these findings, an increase in GCS caused Bcl-xL augmentation, facilitating VNR resistance in lung adenocarcinoma cells...
  52. doi request reprint Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations
    Lecia V Sequist
    Lecia V Sequist, Massachusetts General Hospital and Harvard Medical School, Boston, MA James Chih Hsin Yang, National Taiwan University Hospital Chun Ming Tsai, Taipei Veterans General Hospital, Taipei Wu Chou Su, National Cheng Kung University Hospital, Tainan, Taiwan Nobuyuki Yamamoto, Shizuoka Cancer Center, Shizuoka Terufumi Kato, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan Kenneth O Byrne, St James Hospital, Dublin, Ireland Vera Hirsh, McGill University, Montreal, Quebec, Canada Tony Mok, Prince of Wales Hospital, Hong Kong, China Sarayut Lucien Geater, Songklanagarind Hospital, Songkla, Thailand Sergey Orlov, Pavlov State Medical University, St Petersburg Vera Gorbunova, GU Russian Oncological Research Centre, Moscow, Russia Michael Boyer, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia Jaafar Bennouna, Institut de Cancérologie de l Ouest site René Gauducheau, Nantes, France Ki Hyeong Lee, Chungbuk National University Hospital
    J Clin Oncol 31:3327-34. 2013
    ..A phase II study of afatinib in EGFR mutation-positive lung adenocarcinoma demonstrated high response rates and progression-free survival (PFS)...
  53. ncbi request reprint HER-2/neu raises SHP-2, stops IFN-gamma anti-proliferation in bladder cancer
    Wen Pin Su
    Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan
    Biochem Biophys Res Commun 356:181-6. 2007
    ..The regulation of SHP-2 by HER-2/neu provides a new target for blocking the HER-2/neu oncogenic pathway...
  54. ncbi request reprint A phase II trial of gemcitabine in the treatment of advanced bile duct and periampullary carcinomas
    Ming Hsien Lin
    Division of Hematology Oncology, Department of Internal Medicine, College of Medicine, National Cheng Kung University Hospital, Tainan, Taiwan, ROC
    Chemotherapy 49:154-8. 2003
    ..Gemcitabine is a novel nucleoside analogue with clinical anticancer activity in several malignancies. From September 1998 to April 2000, we treated patients with advanced bile duct and periampullary carcinomas with gemcitabine alone...
  55. doi request reprint Estimation of loss of quality-adjusted life expectancy (QALE) for patients with operable versus inoperable lung cancer: adjusting quality-of-life and lead-time bias for utility of surgery
    Szu Chun Yang
    Department of Internal Medicine, National Cheng Kung University College of Medicine and Hospital, No 138, Sheng Li Road, Tainan 704, Taiwan Department of Public Health, National Cheng Kung University College of Medicine and Hospital, No 138, Sheng Li Road, Tainan 704, Taiwan
    Lung Cancer 86:96-101. 2014
    ..This study attempts to quantify the difference in loss of quality-adjusted life expectancy (QALE) for patients with operable and inoperable non-small-cell lung cancer (NSCLC)...
  56. doi request reprint The down regulation of target genes by photo activated DNA nanoscissors
    Tsung Lin Tsai
    Institute of Basic Medical Sciences, National Cheng Kung University, Tainan 70101, Taiwan
    Biomaterials 31:6545-54. 2010
    ..This photon-mediated DNA manipulation technology will facilitate high spatial and temporal precision in simultaneous silencing at the genome level, and advanced simultaneous manipulation of multiple targeted genes...
  57. doi request reprint Inhibiting glucosylceramide synthase facilitates the radiosensitizing effects of vinorelbine in lung adenocarcinoma cells
    Wei Hsin Chiu
    Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan Division of Hemato Oncology, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan
    Cancer Lett 349:144-51. 2014
    ..Inhibiting glucosylceramide synthase facilitates the radiosensitizing effects of VNR by promoting JNK-mediated apoptosis in lung adenocarcinoma cells...
  58. ncbi request reprint Proteomic analysis of human pleural effusion
    Yu Chang Tyan
    Department of Environmental and Occupational Health, College of Medicine, Tainan, Taiwan
    Proteomics 5:1062-74. 2005
    ..Retinoblastoma binding protein 7 is of special interest since it may play a role in the regulation of cell proliferation and differentiation...
  59. doi request reprint Facile preparation of self-assembled hydrogel-like GdPO4*H2O nanorods
    Chih Chia Huang
    Department of Chemistry, National Cheng Kung University, No 1 University Road, Tainan City, Taiwan
    Langmuir 24:8309-13. 2008
    ..Our findings may lead to the creation of other inorganic nanomaterial-based hydrogels apart from the organic and biomolecular protein-, peptide-, polymer-, and lipid-based building blocks...
  60. doi request reprint Low incidence of thromboembolism in relapsed/refractory myeloma patients treated with thalidomide without thromboprophylaxis in Taiwan
    Shang Yin Wu
    Division of Hematology Oncology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan, 704, Taiwan
    Ann Hematol 91:1773-8. 2012
    ..Even in low TE incidence areas, thalidomide combined with dexamethasone was more thrombogenic compared with others...
  61. pmc Glycogen synthase kinase-3 and Omi/HtrA2 induce annexin A2 cleavage followed by cell cycle inhibition and apoptosis
    Chi Yun Wang
    Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
    Mol Biol Cell 20:4153-61. 2009
    ..Taking these results together, we conclude that GSK-3 and Omi/HtrA2 synergistically cause annexin A2 cleavage and then cell cycle inhibition or apoptosis...
  62. ncbi request reprint Modified, weekly dosing with docetaxel and cisplatin as first-line therapy in advanced non-small cell lung cancer
    Shih Chuan Hsiao
    Department of Haema Oncology, National Cheng Kung University College of Medicine and Hospital, Tainan, Taiwan
    Natl Med J India 22:67-9. 2009
    ..However, the regimens are associated with adverse effects...
  63. pmc The Emergent Landscape of Detecting EGFR Mutations Using Circulating Tumor DNA in Lung Cancer
    Wei Lun Huang
    Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, No 138, Shengli Road, North District, Tainan City 704, Taiwan Institute of Oral Medicine, College of Medicine, National Cheng Kung University, No 1, University Road, East District, Tainan City 704, Taiwan
    Biomed Res Int 2015:340732. 2015
    ..This review not only introduces the biology and clinical implementations of ctDNA but also includes the updating information of recent advancement of techniques for detecting EGFR mutation using ctDNA in lung cancer. ..
  64. pmc Chronic treatment with cisplatin induces replication-dependent sister chromatid recombination to confer cisplatin-resistant phenotype in nasopharyngeal carcinoma
    Wen Pin Su
    Departments of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University Graduate Institutes of Clinical Medicine, College of Medicine, National Cheng Kung University
    Oncotarget 5:6323-37. 2014
    ..Targeting the HR, TS, or FA pathways could be a potential therapeutic strategy for treating cisplatin-resistant cancer. ..
  65. pmc Sp1-mediated microRNA-182 expression regulates lung cancer progression
    Wen Bin Yang
    Institute of Bioinformatics and Biosignal Transduction, College of Bioscience in Biotechnology, National Cheng Kung University, Tainan 701, Taiwan
    Oncotarget 5:740-53. 2014
    ..This stimulates proliferation and tumor growth. In the late stages, Sp1 and miR-182 decline, thus increasing FOXO3 expression, which leads to lung metastasis. ..
  66. ncbi request reprint Expression of DNA repair gene Ku80 in lymphoid neoplasm
    Tsai Yun Chen
    Section of Hematology Oncology, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan
    Eur J Haematol 74:481-8. 2005
    ..Ku80 is a putative tumor suppressor gene that might play an important role in drug resistance. Our aim was to determine the role of Ku80 in lymphoid malignancy...
  67. pmc Nucleolin regulates c-Jun/Sp1-dependent transcriptional activation of cPLA2alpha in phorbol ester-treated non-small cell lung cancer A549 cells
    Jen Hui Tsou
    Department of Pharmacology, National Cheng Kung University, Tainan 701, Taiwan
    Nucleic Acids Res 36:217-27. 2008
    ..It is likely that nucleolin binding at place of Sp1 on gene promoter could also mediate the regulation of c-Jun/Sp1-activated genes...
  68. doi request reprint Angiogenetic biomarkers in non-small cell lung cancer with malignant pleural effusion: correlations with patient survival and pleural effusion control
    I Lin Hsu
    Department of Emergency, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Lung Cancer 65:371-6. 2009
    ....
  69. ncbi request reprint Preemptive use of interferon or lamivudine for hepatitis B reactivation in patients with aggressive lymphoma receiving chemotherapy
    Shiang Jiin Leaw
    Department of Internal Medicine, National Cheng Kung University Hospital Tainan, 138 Sheng Li Road, 70428, Tainan, Taiwan ROC
    Ann Hematol 83:270-5. 2004
    ..Thus, preemptive use of alpha-interferon or lamivudine in HBsAg-positive lymphoma patients undergoing chemotherapy may be a promising approach to prevent HBV reactivation that carries a risk of delayed treatment or even fatal outcome...
  70. ncbi request reprint Successful matched-unrelated bone marrow transplantation in a patient with beta-thalassemia major
    Chao Neng Cheng
    Department of Pediatrics, National Cheng Kung University Hospital, Tainan, Taiwan
    J Pediatr Hematol Oncol 24:579-81. 2002
    ..The authors suggest that BMT from an HLA-matched unrelated donor could be considered as an alternative treatment in patients with beta-thalassemia major when no HLA-matched donor is available...
  71. ncbi request reprint Hormone replacement therapy and lung cancer risk in Chinese
    Kuan Yu Chen
    Division of Pulmonary Medicine, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Cancer 110:1768-75. 2007
    ..The authors investigated whether HRT may reduce lung cancer risk in Taiwan...
  72. doi request reprint High percentage of JAK2 exon 12 mutation in Asian patients with polycythemia vera
    Yu Min Yeh
    Dept of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan
    Am J Clin Pathol 134:266-70. 2010
    ..A clinical laboratory providing the V617F test alone may risk missing a substantial number of patients with PV in areas with a high incidence of exon 12 mutation...
  73. pmc Global Oct4 target gene analysis reveals novel downstream PTEN and TNC genes required for drug-resistance and metastasis in lung cancer
    Yen An Tang
    Institute of Basic Medical Sciences, National Cheng Kung University, No 1, University Road, Tainan 701, Taiwan Department of Pharmacology, National Cheng Kung University, No 1, University Road, Tainan 701, Taiwan
    Nucleic Acids Res 43:1593-608. 2015
    ..Our study reveals a critical Oct4-driven transcriptional program that promotes lung cancer progression, illustrating the therapeutic potential of targeting Oc4 transcriptionally regulated genes. ..
  74. doi request reprint Epidermal growth factor receptor mutation status in stage I lung adenocarcinoma with different image patterns
    Kuo Hsuan Hsu
    Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
    J Thorac Oncol 6:1066-72. 2011
    ..Nevertheless, the correlation between clinical characteristics, CT image patterns, and EGFR mutation status was indeterminate...
  75. doi request reprint A new photothermal therapeutic agent: core-free nanostructured Au x Ag1-x dendrites
    Kuo Wei Hu
    Department of Chemistry, National Cheng Kung University, No 1 University Road, Tainan City, Taiwan
    Chemistry 14:2956-64. 2008
    ..3)Ag(0.7) dendrites relative to those used for Au nanorods. The hollow Au(0.3)Ag(0.7) nanostructured dendrites show potential in photothermolysis for killing cancer cells...
  76. doi request reprint The expression and prognostic significance of platelet-derived growth factor receptor alpha in mature T- and natural killer-cell lymphomas
    Ya ping Chen
    Division of Hematology Oncology, Department of Internal Medicine, National Cheng Kung University Hospital, 138 Sheng Li Road, Tainan, 704, Taiwan
    Ann Hematol 87:985-90. 2008
    ..PDGFRA expression in PTCLu was lower in the present study than in previous reports done in Western countries. It suggests that this disease is biologically distinct in different races (30.4% vs. 91-100%)...
  77. pmc Oncogenic Ras-induced morphologic change is through MEK/ERK signaling pathway to downregulate Stat3 at a posttranslational level in NIH3T3 cells
    Hsuan Heng Yeh
    Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan
    Neoplasia 10:52-60. 2008
    ..Our finding may shed light on developing novel therapeutic strategies against Ras-related tumorigenesis...
  78. ncbi request reprint Hypoxia-inducible factor-1alpha correlates with MET and metastasis in node-negative breast cancer
    Helen H W Chen
    Department of Radiation Oncology, National Cheng Kung University Hospital, Tainan, Taiwan
    Breast Cancer Res Treat 103:167-75. 2007
    ....
  79. doi request reprint Interactive effect of cigarette smoking with human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) polymorphisms on the risk of lung cancer: a case-control study in Taiwan
    Chin Hao Chang
    Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan, Republic of China
    Am J Epidemiol 170:695-702. 2009
    ..The authors conclude that there was a noticeable modifying effect on the association between hOGG1 genotype and lung cancer risk by cigarette smoking status...
  80. doi request reprint Malignant pleural effusion cells show aberrant glucose metabolism gene expression
    C C Lin
    Division of Hematology Oncology, Department of Internal Medicine, Hospital and Graduate Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan 704, Taiwan
    Eur Respir J 37:1453-65. 2011
    ..TKT regulated the proliferation, vascular endothelial growth factor secretion in vitro and in vivo vascular permeability of cancer cell. Glucose metabolic reprogramming by ALDOA, SORD, TKT and TSC1 is important in MPE pathogenesis...
  81. ncbi request reprint Chromosomal aberrations of malignant pleural effusions of lung adenocarcinoma: different cytogenetic changes are correlated with genders and smoking habits
    Chueh Chuan Yen
    Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Lung Cancer 57:292-301. 2007
    ..The role of LDHC in the carcinogenesis of smoking-related lung adenocarcinoma, especially in male patients with pleural effusions, deserves further investigations...