Liang Chuan Lai

Summary

Affiliation: National Taiwan University
Country: Taiwan

Publications

  1. pmc ADAM9 up-regulates N-cadherin via miR-218 suppression in lung adenocarcinoma cells
    Yuh Pyng Sher
    Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan
    PLoS ONE 9:e94065. 2014
  2. pmc SNP rs10248565 in HDAC9 as a novel genomic aberration biomarker of lung adenocarcinoma in non-smoking women
    Liang Chuan Lai
    Graduate Institute of Physiology, National Taiwan University, Taipei, Taiwan
    J Biomed Sci 21:24. 2014
  3. pmc Comparison of the transcriptomic "stress response" evoked by antimycin A and oxygen deprivation in Saccharomyces cerevisiae
    Liang Chuan Lai
    Department of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan, ROC
    BMC Genomics 9:627. 2008
  4. pmc Genetic polymorphisms of nerve growth factor receptor (NGFR) and the risk of Alzheimer's disease
    Hui Chi Cheng
    Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan
    J Negat Results Biomed 11:5. 2012
  5. pmc Concurrent gene signatures for han chinese breast cancers
    Chi Cheng Huang
    Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei City, Taiwan Cathay General Hospital SiJhih, New, Taipei City, Taiwan School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan School of Medicine, Taipei Medical University, Taipei City, Taiwan
    PLoS ONE 8:e76421. 2013
  6. pmc Molecular characteristics and metastasis predictor genes of triple-negative breast cancer: a clinical study of triple-negative breast carcinomas
    Wen Hung Kuo
    Department of Surgery, College of Medicine, National Taiwan University, Taipei, Taiwan
    PLoS ONE 7:e45831. 2012
  7. pmc Integrated analyses of copy number variations and gene expression in lung adenocarcinoma
    Tzu Pin Lu
    Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan
    PLoS ONE 6:e24829. 2011
  8. pmc Deregulated microRNAs in triple-negative breast cancer revealed by deep sequencing
    Yao Yin Chang
    Department of Electrical Engineering, Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan
    Mol Cancer 14:36. 2015
  9. pmc MicroRNA-449a enhances radiosensitivity in CL1-0 lung adenocarcinoma cells
    Yi Jyun Liu
    Graduate Institute of Physiology, National Taiwan University, Taipei, Taiwan
    PLoS ONE 8:e62383. 2013
  10. pmc Disease-targeted sequencing of ion channel genes identifies de novo mutations in patients with non-familial Brugada syndrome
    Jyh Ming Jimmy Juang
    1 Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, National Taiwan University Hospital Taipei, 10002, Taiwan 2 Graduate Institute of Physiology, National Taiwan University, Taipei 10617, Taiwan
    Sci Rep 4:6733. 2014

Collaborators

Detail Information

Publications36

  1. pmc ADAM9 up-regulates N-cadherin via miR-218 suppression in lung adenocarcinoma cells
    Yuh Pyng Sher
    Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan
    PLoS ONE 9:e94065. 2014
    ..The down-regulation of ADAM9 up-regulated SLIT2 and miR-218, thus down-regulating CDH2 expression. This study revealed that ADAM9 activates CDH2 through the release of miR-218 inhibition on CDH2 in lung adenocarcinoma. ..
  2. pmc SNP rs10248565 in HDAC9 as a novel genomic aberration biomarker of lung adenocarcinoma in non-smoking women
    Liang Chuan Lai
    Graduate Institute of Physiology, National Taiwan University, Taipei, Taiwan
    J Biomed Sci 21:24. 2014
    ..Since cancer results from progressive accumulation of genetic aberrations, genomic rearrangements may be early events in carcinogenesis...
  3. pmc Comparison of the transcriptomic "stress response" evoked by antimycin A and oxygen deprivation in Saccharomyces cerevisiae
    Liang Chuan Lai
    Department of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan, ROC
    BMC Genomics 9:627. 2008
    ..Here we compared functional and regulatory aspects of the stress responses elicited by the acute inhibition of respiration with antimycin A and oxygen deprivation under catabolite non-repressed (galactose) conditions...
  4. pmc Genetic polymorphisms of nerve growth factor receptor (NGFR) and the risk of Alzheimer's disease
    Hui Chi Cheng
    Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan
    J Negat Results Biomed 11:5. 2012
    ..Only one study has investigated the association between NGFR polymorphisms and the risk of AD in an Italian population. Type 2 diabetes mellitus (DM) may modify this association based on previous animal and epidemiologic studies...
  5. pmc Concurrent gene signatures for han chinese breast cancers
    Chi Cheng Huang
    Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei City, Taiwan Cathay General Hospital SiJhih, New, Taipei City, Taiwan School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan School of Medicine, Taipei Medical University, Taipei City, Taiwan
    PLoS ONE 8:e76421. 2013
    ..We conclude that parallel analysis of CGH and microarray data, in conjunction with known gene expression patterns, can be used to identify biomarkers with prognostic values in breast cancer. ..
  6. pmc Molecular characteristics and metastasis predictor genes of triple-negative breast cancer: a clinical study of triple-negative breast carcinomas
    Wen Hung Kuo
    Department of Surgery, College of Medicine, National Taiwan University, Taipei, Taiwan
    PLoS ONE 7:e45831. 2012
    ..Reliable identification of triple-negative patients with a favorable prognosis is not yet possible...
  7. pmc Integrated analyses of copy number variations and gene expression in lung adenocarcinoma
    Tzu Pin Lu
    Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan
    PLoS ONE 6:e24829. 2011
    ..In conclusion, by integrating gene expression profiles and copy number variations, we identified genes/pathways that may serve as prognostic biomarkers for lung tumorigenesis...
  8. pmc Deregulated microRNAs in triple-negative breast cancer revealed by deep sequencing
    Yao Yin Chang
    Department of Electrical Engineering, Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan
    Mol Cancer 14:36. 2015
    ....
  9. pmc MicroRNA-449a enhances radiosensitivity in CL1-0 lung adenocarcinoma cells
    Yi Jyun Liu
    Graduate Institute of Physiology, National Taiwan University, Taipei, Taiwan
    PLoS ONE 8:e62383. 2013
    ..Overexpression of miR-449a in CL1-0 cells effectively increased irradiation-induced DNA damage and apoptosis, altered the cell cycle distribution and eventually led to sensitization of CL1-0 to irradiation...
  10. pmc Disease-targeted sequencing of ion channel genes identifies de novo mutations in patients with non-familial Brugada syndrome
    Jyh Ming Jimmy Juang
    1 Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, National Taiwan University Hospital Taipei, 10002, Taiwan 2 Graduate Institute of Physiology, National Taiwan University, Taipei 10617, Taiwan
    Sci Rep 4:6733. 2014
    ..This study identified four novel BrS-associated genes and indicated the effectiveness of this disease-targeted sequencing across ion channel genes for non-familial BrS patients without SCN5A variants. ..
  11. pmc miRSystem: an integrated system for characterizing enriched functions and pathways of microRNA targets
    Tzu Pin Lu
    YongLin Biomedical Engineering Center, National Taiwan University, Taipei, Taiwan
    PLoS ONE 7:e42390. 2012
    ..To address these issues, we developed a web-based system, miRSystem, for converting queried miRNAs to the latest annotation and predicting the function of miRNA by integrating miRNA target gene prediction and function/pathway analyses...
  12. pmc MicroRNA-769-3p down-regulates NDRG1 and enhances apoptosis in MCF-7 cells during reoxygenation
    En Ching Luo
    Graduate Institute of Physiology, National Taiwan University, Taipei, Taiwan
    Sci Rep 4:5908. 2014
    ..Furthermore, overexpression of miR-769-3p significantly inhibited cell proliferation and enhanced apoptosis. Our results revealed that miR-769-3p can functionally regulate NDRG1 during changes in oxygen concentration...
  13. pmc Identification of prognostic genes for recurrent risk prediction in triple negative breast cancer patients in Taiwan
    Lee H Chen
    Bioinformatics and Biostatistics Core, Center of Genomic Medicine, National Taiwan University, Taipei, Taiwan
    PLoS ONE 6:e28222. 2011
    ..These results could be used for assisting with clinical prognosis and warrant further investigation into the possibility of targeted therapy of triple negative breast cancer in Taiwanese patients...
  14. pmc Down-regulation of NDRG1 promotes migration of cancer cells during reoxygenation
    Liang Chuan Lai
    Graduate Institute of Physiology, National Taiwan University, Taipei, Taiwan
    PLoS ONE 6:e24375. 2011
    ..Our results revealed the dynamic nature of gene expression in MCF-7 cells upon reoxygenation and demonstrated that NDRG1 is involved in tumor adaptation to reoxygenation...
  15. pmc Multiclass prediction with partial least square regression for gene expression data: applications in breast cancer intrinsic taxonomy
    Chi Cheng Huang
    Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, No 1, Section 4, Roosevelt Road, Taipei 10617, Taiwan Cathay General Hospital SiJhih, New Taipei, Taiwan School of Medicine, Fu Jen Catholic University, New Taipei, Taiwan School of Medicine, Taipei Medical University, Taipei, Taiwan
    Biomed Res Int 2013:248648. 2013
    ..Our study ascertained the feasibility of PLS-regression in multi-class prediction, and distinct clinical presentations and prognostic discrepancies were observed across breast cancer molecular subtypes. ..
  16. doi request reprint Refinement of breast cancer risk prediction with concordant leading edge subsets from prognostic gene signatures
    Chi Cheng Huang
    Graduate Institute of Biomedical Electronics and Bioinformatics, Department of Electrical Engineering, National Taiwan University, Taipei, 106, Taiwan
    Breast Cancer Res Treat 147:353-70. 2014
    ..The present study provides a statistical framework for identifying core consensus across microarray studies with leading edge analysis, and a breast cancer risk predictive model was established. ..
  17. pmc Identification of regulatory SNPs associated with genetic modifications in lung adenocarcinoma
    Tzu Pin Lu
    Department of Public Health, Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan
    BMC Res Notes 8:92. 2015
    ..0, Affymetrix SNP 6.0, and Illumina Infinium Methylation microarrays. Copy number variations (CNVs) and methylation alterations were analyzed and paired t-tests were used to identify differentially expressed genes...
  18. doi request reprint Identification of a novel biomarker, SEMA5A, for non-small cell lung carcinoma in nonsmoking women
    Tzu Pin Lu
    Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan
    Cancer Epidemiol Biomarkers Prev 19:2590-7. 2010
    ..This report is a comprehensive analysis of the molecular signature of nonsmoking female lung cancer patients in Taiwan, with a particular focus on the semaphorin gene family...
  19. pmc Prediction consistency and clinical presentations of breast cancer molecular subtypes for Han Chinese population
    Chi Cheng Huang
    Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei City, Taiwan
    J Transl Med 10:S10. 2012
    ....
  20. doi request reprint Mitomycin C treatment induces resistance and enhanced migration via phosphorylated Akt in aggressive lung cancer cells
    Cheng Ying Shen
    Institute of Biotechnology, National Taiwan University, Taipei, Taiwan
    Oncotarget . 2016
    ..This study suggests that in CL1-5 cells, the activity of p-Akt, rather than DNA repair mechanisms, may underlie the resistance to MMC and enhance the cells' migration abilities after MMC treatment...
  21. pmc Aryl Hydrocarbon Receptor Activates NDRG1 Transcription under Hypoxia in Breast Cancer Cells
    En Yu Li
    Graduate Institute of Physiology, National Taiwan University, Taipei, Taiwan
    Sci Rep 6:20808. 2016
    ....
  22. pmc Development of a prediction model for radiosensitivity using the expression values of genes and long non-coding RNAs
    Wei An Wang
    Graduate Institute of Biomedical Electronics and Bioinformatics and Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan
    Oncotarget 7:26739-50. 2016
    ..The model was applied to 2 datasets of glioblastoma, The Cancer Genome Atlas and GSE16011, and significantly better survival was observed in patients with greater predicted radiosensitivity. ..
  23. pmc Identification of genes with consistent methylation levels across different human tissues
    Tzu Pin Lu
    1 YongLin Biomedical Engineering Center, National Taiwan University, Taipei, Taiwan 2 Bioinformatics and Biostatistics Core, Center of Genomic Medicine, National Taiwan University, Taipei, Taiwan
    Sci Rep 4:4351. 2014
    ....
  24. pmc Transcription of Tnfaip3 is regulated by NF-κB and p38 via C/EBPβ in activated macrophages
    Ting Yu Lai
    Institute of Molecular Medicine, National Taiwan University, Taipei, Taiwan
    PLoS ONE 8:e73153. 2013
    ..These results identify a novel regulatory mechanism in TLR4-mediated innate immunity. ..
  25. doi request reprint Deregulated microRNAs in triple-negative breast cancer revealed by deep sequencing
    Yao Yin Chang
    Department of Electrical Engineering, Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan
    Mol Cancer 14:301. 2015
    ....
  26. pmc iGC-an integrated analysis package of gene expression and copy number alteration
    Yi Pin Lai
    Bioinformatics and Biostatistics Core, Center of Genomic Medicine, National Taiwan University, Taipei, Taiwan
    BMC Bioinformatics 18:35. 2017
    ..To address these issues, one possible approach is to concurrently analyze both gene expression profiling and CNAs in the same individual...
  27. pmc Putative effectors for prognosis in lung adenocarcinoma are ethnic and gender specific
    Andrew Woolston
    Institute of Statistical Science, Academia Sinica, Taipei, Taiwan
    Oncotarget 6:19483-99. 2015
    ..This discovery has profound implications in diagnosis and treatment of lung adenocarcinoma and echoes the fundamental principles of the personalized medicine paradigm. ..
  28. pmc Identification of gene expression biomarkers for predicting radiation exposure
    Tzu Pin Lu
    1 Department of Public Health, National Taiwan University, Taipei, Taiwan 2 Graduate Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan
    Sci Rep 4:6293. 2014
    ..In conclusion, this study demonstrates a reliable method for identifying biomarkers across independent studies and high and reproducible prediction accuracy was demonstrated in both internal and external datasets. ..
  29. doi request reprint DBCAT: database of CpG islands and analytical tools for identifying comprehensive methylation profiles in cancer cells
    Hsien Chi Kuo
    Research Center For Medical Excellence, National Taiwan University, Taipei, Taiwan
    J Comput Biol 18:1013-7. 2011
    ....
  30. doi request reprint Distinct signaling pathways after higher or lower doses of radiation in three closely related human lymphoblast cell lines
    Tzu Pin Lu
    Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan
    Int J Radiat Oncol Biol Phys 76:212-9. 2010
    ..The tumor suppressor p53 plays an essential role in cellular responses to DNA damage caused by ionizing radiation; therefore, this study aims to further explore the role that p53 plays at different doses of radiation...
  31. pmc SLCO3A1, A novel crohn's disease-associated gene, regulates nf-κB activity and associates with intestinal perforation
    Shu Chen Wei
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    PLoS ONE 9:e100515. 2014
    ..This study was designed to identify novel CD-associated single nucleotide polymorphisms (SNPs)/genes and to validate candidate genes using a functional assay...
  32. pmc A model-based circular binary segmentation algorithm for the analysis of array CGH data
    Fang Han Hsu
    Graduate Institute of Biomedical Electronics and Bioinformatics, Department of Electrical Engineering, National Taiwan University, Taipei 106, Taiwan
    BMC Res Notes 4:394. 2011
    ..In addition, what the hybrid method provides is an approximation of the significance upper bound or lower bound, not an approximation of the significance of change-points itself...
  33. pmc Sequence variants of interleukin 6 (IL-6) are significantly associated with a decreased risk of late-onset Alzheimer's disease
    Shih Yuan Chen
    Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan
    J Neuroinflammation 9:21. 2012
    ..However, previous studies relating IL-6 genetic polymorphisms to AD included few and unrepresentative single nucleotide polymorphisms (SNPs) and the results were inconsistent...
  34. pmc IL-1β-driven neutrophilia preserves antibacterial defense in the absence of the kinase IKKβ
    Li Chung Hsu
    Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
    Nat Immunol 12:144-50. 2011
    ....
  35. pmc Genetic polymorphisms of a novel vascular susceptibility gene, Ninjurin2 (NINJ2), are associated with a decreased risk of Alzheimer's disease
    Kun Pei Lin
    Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan
    PLoS ONE 6:e20573. 2011
    ..This study investigated the association between genetic polymorphisms of a vascular susceptibility gene, Ninjurin2 (NINJ2), and the risk of dementia, which has not been explored previously...
  36. pmc Utilizing multiple in silico analyses to identify putative causal SCN5A variants in Brugada syndrome
    Jyh Ming Jimmy Juang
    1 Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan 2 Graduate Institute of Physiology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Sci Rep 4:3850. 2014
    ....