Song Kun Shyue

Summary

Affiliation: Academia Sinica
Country: Taiwan

Publications

  1. pmc 14-3-3σ induces heat shock protein 70 expression in hepatocellular carcinoma
    Chia Chia Liu
    Institute of Biotechnology, National Taiwan University, Taipei 106, Taiwan
    BMC Cancer 14:425. 2014
  2. doi request reprint AMP-activated protein kinase mediates erythropoietin-induced activation of endothelial nitric oxide synthase
    Kuo Hui Su
    Department of Physiology, School of Medicine, National Yang Ming University, Taipei, Taiwan
    J Cell Physiol 227:3053-62. 2012
  3. pmc Reduction in antioxidant enzyme expression and sustained inflammation enhance tissue damage in the subacute phase of spinal cord contusive injury
    Chih Yen Wang
    Department of Life Sciences, National Cheng Kung University, Tainan, Taiwan
    J Biomed Sci 18:13. 2011
  4. doi request reprint β Common receptor integrates the erythropoietin signaling in activation of endothelial nitric oxide synthase
    Kuo Hui Su
    Department of Physiology, National Yang Ming University, Taipei, Taiwan
    J Cell Physiol 226:3330-9. 2011
  5. ncbi request reprint Superoxide dismutase inhibits the expression of vascular cell adhesion molecule-1 and intracellular cell adhesion molecule-1 induced by tumor necrosis factor-alpha in human endothelial cells through the JNK/p38 pathways
    Shing Jong Lin
    Institute of Clinical Medicine, Cardiovascular Research Center, National Yang Ming University, Taiwan, Republic of China
    Arterioscler Thromb Vasc Biol 25:334-40. 2005
  6. doi request reprint Molecular mechanisms of activation of endothelial nitric oxide synthase mediated by transient receptor potential vanilloid type 1
    Li Chieh Ching
    Department of Physiology, National Yang Ming University, Taipei, Taiwan
    Cardiovasc Res 91:492-501. 2011
  7. ncbi request reprint 15d-prostaglandin J2 protects brain from ischemia-reperfusion injury
    Teng Nan Lin
    Neuroscience Division, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Arterioscler Thromb Vasc Biol 26:481-7. 2006
  8. doi request reprint Excess nitric oxide impairs LXR(α)-ABCA1-dependent cholesterol efflux in macrophage foam cells
    Jin Feng Zhao
    Department of Physiology, National Yang Ming University, Taipei, Taiwan
    J Cell Physiol 229:117-25. 2014
  9. doi request reprint Wogonin promotes cholesterol efflux by increasing protein phosphatase 2B-dependent dephosphorylation at ATP-binding cassette transporter-A1 in macrophages
    Chien yu Chen
    Department of Physiology, National Yang Ming University, Taipei, Taiwan
    J Nutr Biochem 22:1015-21. 2011
  10. ncbi request reprint Cyclooxygenase-1 and bicistronic cyclooxygenase-1/prostacyclin synthase gene transfer protect against ischemic cerebral infarction
    Heng Lin
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Circulation 105:1962-9. 2002

Collaborators

Detail Information

Publications39

  1. pmc 14-3-3σ induces heat shock protein 70 expression in hepatocellular carcinoma
    Chia Chia Liu
    Institute of Biotechnology, National Taiwan University, Taipei 106, Taiwan
    BMC Cancer 14:425. 2014
    ..14-3-3σ is implicated in promoting tumor development of various malignancies. However, the clinical relevance of 14-3-3σ in hepatocellular carcinoma (HCC) tumor progression and modulation and pathway elucidation remain unclear...
  2. doi request reprint AMP-activated protein kinase mediates erythropoietin-induced activation of endothelial nitric oxide synthase
    Kuo Hui Su
    Department of Physiology, School of Medicine, National Yang Ming University, Taipei, Taiwan
    J Cell Physiol 227:3053-62. 2012
    ..Taken together, EPO may trigger AMPK-dependent signaling, which leads to enhanced phosphorylation of βCR and eNOS, increased βCR-AMPK-eNOS complex formation, NO production, and, ultimately, angiogenesis...
  3. pmc Reduction in antioxidant enzyme expression and sustained inflammation enhance tissue damage in the subacute phase of spinal cord contusive injury
    Chih Yen Wang
    Department of Life Sciences, National Cheng Kung University, Tainan, Taiwan
    J Biomed Sci 18:13. 2011
    ..To consider an appropriate time window for giving a promising therapeutic treatment for subacute and chronic SCI, global changes of proteins in the injured center at the longer survival time points after SCI remains to be elucidated...
  4. doi request reprint β Common receptor integrates the erythropoietin signaling in activation of endothelial nitric oxide synthase
    Kuo Hui Su
    Department of Physiology, National Yang Ming University, Taipei, Taiwan
    J Cell Physiol 226:3330-9. 2011
    ..Our findings suggest that βCR may play an integrative role in the EPO signaling-mediated activation of eNOS in ECs...
  5. ncbi request reprint Superoxide dismutase inhibits the expression of vascular cell adhesion molecule-1 and intracellular cell adhesion molecule-1 induced by tumor necrosis factor-alpha in human endothelial cells through the JNK/p38 pathways
    Shing Jong Lin
    Institute of Clinical Medicine, Cardiovascular Research Center, National Yang Ming University, Taiwan, Republic of China
    Arterioscler Thromb Vasc Biol 25:334-40. 2005
    ..We tried to study possible effects of Cu/Zn superoxide dismutase (SOD) on adhesion molecule expression and its underlying mechanism in the prevention and treatment of cardiovascular disorders...
  6. doi request reprint Molecular mechanisms of activation of endothelial nitric oxide synthase mediated by transient receptor potential vanilloid type 1
    Li Chieh Ching
    Department of Physiology, National Yang Ming University, Taipei, Taiwan
    Cardiovasc Res 91:492-501. 2011
    ....
  7. ncbi request reprint 15d-prostaglandin J2 protects brain from ischemia-reperfusion injury
    Teng Nan Lin
    Neuroscience Division, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Arterioscler Thromb Vasc Biol 26:481-7. 2006
    ..The aim of this study is to assess the effect of 15d-PGJ2 on neuroprotection...
  8. doi request reprint Excess nitric oxide impairs LXR(α)-ABCA1-dependent cholesterol efflux in macrophage foam cells
    Jin Feng Zhao
    Department of Physiology, National Yang Ming University, Taipei, Taiwan
    J Cell Physiol 229:117-25. 2014
    ..Our findings provide new insights in the pro-atherogenic effect of excess NO on cholesterol metabolism in macrophages...
  9. doi request reprint Wogonin promotes cholesterol efflux by increasing protein phosphatase 2B-dependent dephosphorylation at ATP-binding cassette transporter-A1 in macrophages
    Chien yu Chen
    Department of Physiology, National Yang Ming University, Taipei, Taiwan
    J Nutr Biochem 22:1015-21. 2011
    ..Collectively, wogonin increases the protein stability of ABCA1 via PP2B-mediated dephosphorylation, thus leading to reduced cholesterol accumulation in macrophage foam cells...
  10. ncbi request reprint Cyclooxygenase-1 and bicistronic cyclooxygenase-1/prostacyclin synthase gene transfer protect against ischemic cerebral infarction
    Heng Lin
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Circulation 105:1962-9. 2002
    ..We tested the hypothesis that bicistronic cyclooxygenase-1 (COX-1)/prostacyclin synthase (PGIS) and COX-1 gene transfer reduce cerebral infarct volume by augmenting synthesis of protective prostaglandins...
  11. doi request reprint Molecular mechanism of curcumin on the suppression of cholesterol accumulation in macrophage foam cells and atherosclerosis
    Jing Feng Zhao
    Department of Physiology, National Yang Ming University, Taipei, Taiwan
    Mol Nutr Food Res 56:691-701. 2012
    ..In this study, we examined the effect of curcumin on lipid accumulation and the underlying molecular mechanisms in macrophages and apolipoprotein E-deficient (apoE⁻/⁻) mice...
  12. pmc Activation of TRPV1 prevents OxLDL-induced lipid accumulation and TNF-α-induced inflammation in macrophages: role of liver X receptor α
    Jin Feng Zhao
    Department of Physiology, School of Medicine, National Yang Ming University, Taipei 11221, Taiwan
    Mediators Inflamm 2013:925171. 2013
    ..Our data suggest that LXR α plays a pivotal role in TRPV1-activation-conferred protection against oxLDL-induced lipid accumulation and TNF-α-induced inflammation in macrophages...
  13. doi request reprint α-Lipoic acid ameliorates foam cell formation via liver X receptor α-dependent upregulation of ATP-binding cassette transporters A1 and G1
    Li Ching Cheng
    Institute of Physiology, National Yang Ming University, Taipei 11211, Taiwan
    Free Radic Biol Med 50:47-54. 2011
    ..In conclusion, LXRα-dependent upregulation of ABCA1 and ABCG1 may mediate the beneficial effect of α-LA on foam cell formation...
  14. doi request reprint EGb761 ameliorates the formation of foam cells by regulating the expression of SR-A and ABCA1: role of haem oxygenase-1
    Jin Yi Tsai
    Department of Physiology, National Yang Ming University, Taipei, Taiwan
    Cardiovasc Res 88:415-23. 2010
    ....
  15. pmc Deficiency of glycine N-methyltransferase aggravates atherosclerosis in apolipoprotein E-null mice
    Chien yu Chen
    Department of Physiology, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Mol Med 18:744-52. 2012
    ..This finding may reveal a potential therapeutic target for atherosclerosis...
  16. doi request reprint Novel effect of paeonol on the formation of foam cells: promotion of LXRα-ABCA1-dependent cholesterol efflux in macrophages
    Jin Feng Zhao
    Department of Physiology, National Yang Ming University, Taipei 11221, Taiwan
    Am J Chin Med 41:1079-96. 2013
    ..Paeonol may alleviate the formation of foam cells by enhancing LXRα-ABCA1-dependent cholesterol efflux...
  17. doi request reprint Activation of soluble guanylyl cyclase prevents foam cell formation and atherosclerosis
    C Y Tsou
    Department of Physiology, National Yang Ming University, Taipei, Taiwan
    Acta Physiol (Oxf) 210:799-810. 2014
    ..Soluble guanylyl cyclase (sGC) is a key modulator in the regulation of vascular tone. However, its role and involving mechanism in cholesterol metabolism of macrophages and atherosclerosis remain unclear...
  18. pmc N-terminal domain of soluble epoxide hydrolase negatively regulates the VEGF-mediated activation of endothelial nitric oxide synthase
    Hsin Han Hou
    Institute of Physiology, National Yang Ming University, Taipei, Taiwan
    Cardiovasc Res 93:120-9. 2012
    ..However, far less is known about the role of sEH phosphatase activity in eNOS activation. In the present study, we investigated whether the phosphatase domain of sEH was involved in the eNOS activation in ECs...
  19. doi request reprint Implication of AMP-activated protein kinase in transient receptor potential vanilloid type 1-mediated activation of endothelial nitric oxide synthase
    Li Chieh Ching
    Department of Physiology, School of Medicine, National Yang Ming University, Taipei 11221, Taiwan
    Mol Med 18:805-15. 2012
    ..In conclusion, TRPV1 activation may trigger AMPK-dependent signaling, which leads to enhanced activation of AMPK and eNOS and retarded development of atherosclerosis. ..
  20. pmc Implication of transient receptor potential vanilloid type 1 in 14,15-epoxyeicosatrienoic acid-induced angiogenesis
    Kuo Hui Su
    1 Department of Physiology, School of Medicine, National Yang Ming University, Taipei, 11221 Taiwan
    Int J Biol Sci 10:990-6. 2014
    ..In an animal experiment, 14,15-EET-induced angiogenesis was diminished by inhibition of TRPV1 and in TRPV1-deficient mice. TRPV1 may play a crucial role in 14,15-EET-induced Ca(2+) influx, NO production and angiogenesis. ..
  21. doi request reprint Transient receptor potential vanilloid type 1 is vital for (-)-epigallocatechin-3-gallate mediated activation of endothelial nitric oxide synthase
    Bei Chia Guo
    Department of Physiology, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Mol Nutr Food Res 59:646-57. 2015
    ..In this study, we investigated the role of transient receptor potential vanilloid type 1 (TRPV1), a ligand-gated nonselective calcium channel, in EGCG-mediated endothelial nitric oxide (NO) synthase (eNOS) activation and angiogenesis...
  22. doi request reprint Inflammatory role of AMP-activated protein kinase signaling in an experimental model of toxic smoke inhalation injury
    Diahn Warng Perng
    Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Crit Care Med 41:120-32. 2013
    ..We investigated the signaling pathway responsible for the induction of interleukin 8 by wood smoke extract in lung epithelial cells and lung inflammation induced by wood smoke exposure in mice...
  23. doi request reprint Anti-atherogenic effect of berberine on LXRalpha-ABCA1-dependent cholesterol efflux in macrophages
    Tzong Shyuan Lee
    Institute of Physiology, National Yang Ming University, Taipei 11221, Taiwan, ROC
    J Cell Biochem 111:104-10. 2010
    ..These data suggest that berberine abrogates the formation of foam cells by macrophages by enhancing LXRalpha-ABCA1-dependent cholesterol efflux...
  24. doi request reprint Valsartan regulates the interaction of angiotensin II type 1 receptor and endothelial nitric oxide synthase via Src/PI3K/Akt signalling
    Kuo Hui Su
    Department of Physiology, National Yang Ming University, Taipei, Taiwan, ROC
    Cardiovasc Res 82:468-75. 2009
    ..We investigated the molecular mechanisms underlying this effect in endothelial cells (ECs)...
  25. doi request reprint Di-(2-ethylhexyl) phthalate accelerates atherosclerosis in apolipoprotein E-deficient mice
    Jin Feng Zhao
    Department of Physiology, School of Medicine, National Yang Ming University, Taipei, 11221, Taiwan
    Arch Toxicol 90:181-90. 2016
    ..In conclusion, DEHP may disturb cholesterol homeostasis and deregulate the inflammatory response, thus leading to accelerated atherosclerosis. ..
  26. pmc Role of phosphatase activity of soluble epoxide hydrolase in regulating simvastatin-activated endothelial nitric oxide synthase
    Hsin Han Hou
    Department of Physiology, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Sci Rep 5:13524. 2015
    ..These findings suggest that sEH phosphatase activity negatively regulates simvastatin-activated eNOS by impeding the Akt-AMPK-eNOS signaling cascade. ..
  27. doi request reprint Role of glycine N-methyltransferase in experimental ulcerative colitis
    Wen Yueh Chou
    Department of Physiology, School of Medicine, National Yang Ming University, Taipei, Taiwan
    J Gastroenterol Hepatol 29:494-501. 2014
    ..However, little is known about the impact of GNMT and the involved mechanism in the pathogenesis of IBD. In the current study, we investigated the role of GNMT in the mouse model of dextran sulfate sodium (DSS)-induced colitis...
  28. pmc Transient Receptor Potential Ankyrin 1 Channel Involved in Atherosclerosis and Macrophage-Foam Cell Formation
    Jin Feng Zhao
    1 Department of Physiology, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Int J Biol Sci 12:812-23. 2016
    ..TRPA1 may be a pivotal regulator in the pathogenesis of atherosclerosis and cholesterol metabolism of macrophage foam cells...
  29. pmc Caveolin-1 deletion reduces early brain injury after experimental intracerebral hemorrhage
    Che Feng Chang
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
    Am J Pathol 178:1749-61. 2011
    ..These data suggest that Cav-1 plays a deleterious role in early brain injury after ICH. Inhibition of Cav-1 may provide a novel therapeutic approach for the treatment of hemorrhagic stroke...
  30. pmc Role of transient receptor potential ankyrin 1 channels in Alzheimer's disease
    Kuan I Lee
    Department of Physiology, School of Medicine, National Yang Ming University, Taipei, Taiwan
    J Neuroinflammation 13:92. 2016
    ..Transient receptor potential ankyrin 1 (TRPA1) channel plays an important role in pain and inflammation. However, little is known about the significance of the TRPA1 channel in the pathophysiology of Alzheimer's disease (AD)...
  31. pmc Excess Nitric Oxide Activates TRPV1-Ca(2+)-Calpain Signaling and Promotes PEST-dependent Degradation of Liver X Receptor α
    Jin Feng Zhao
    1 Department of Physiology, National Yang Ming University, Taipei, 11221, Taiwan
    Int J Biol Sci 12:18-29. 2016
    ....
  32. pmc Linear correlation between average fluorescence intensity of green fluorescent protein and the multiplicity of infection of recombinant adenovirus
    Yi Chen Tsai
    Graduate School of Life Science, National Defense Medical Center, Taipei, 11490, Taiwan
    J Biomed Sci 22:31. 2015
    ..Adenoviral vector is an efficient tool for gene transfer. Protein expression is regulated by a number of factors, but the regulation by gene copy number remains to be investigated further...
  33. pmc Cancer immunotherapy using a membrane-bound interleukin-12 with B7-1 transmembrane and cytoplasmic domains
    Wen Yu Pan
    Taiwan International Graduate Program, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Mol Ther 20:927-37. 2012
    ..Our data demonstrate that cancer immunotherapy using membrane-bound IL-12 has the advantage of minimizing systemic IL-12 levels without compromising its antitumor efficacy...
  34. pmc Dual biological functions of an interleukin-1 receptor antagonist-interleukin-10 fusion protein and its suppressive effects on joint inflammation
    Deh Ming Chang
    Rheumatology Immunology Allergy, Department of Internal Medicine, Tri Service General Hospital, National Defense Medical Center, 325 Cheng Kung Road Section 2, Neihu 114, Taipei, Taiwan, China
    Immunology 112:643-50. 2004
    ..Our investigations indicate that this fusion protein effectively suppresses inflammatory arthritis and may initiate a trend for future clinical application to target multiple molecules at the same time...
  35. pmc Growth arrest DNA damage-inducible gene 45 gamma expression as a prognostic and predictive biomarker in hepatocellular carcinoma
    Da Liang Ou
    Graduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Oncotarget 6:27953-65. 2015
    ..The preceding data indicate that GADD45γ suppression is a poor prognostic factor in patients with HCC and may help predict sorafenib efficacy in HCC. ..
  36. ncbi request reprint Superoxide dismutase and catalase inhibit oxidized low-density lipoprotein-induced human aortic smooth muscle cell proliferation: role of cell-cycle regulation, mitogen-activated protein kinases, and transcription factors
    Shing Jong Lin
    Institute of Clinical Medicine, National Yang Ming University, Taiwan, Republic of China
    Atherosclerosis 190:124-34. 2007
    ..These observations support the feasibility of the increase of Cu, Zn-SOD and/or catalase expression in human smooth muscle cells as a means of protection against oxidant injury...
  37. ncbi request reprint Induction of prostacyclin/PGI2 synthase expression after cerebral ischemia-reperfusion
    Yao Ching Fang
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, ROC
    J Cereb Blood Flow Metab 26:491-501. 2006
    ..These findings indicate that PGIS protects the brain by enhancing PGI2 synthesis and creating a favorable PGI2/TXA2 ratio...
  38. pmc Spatial and temporal distribution of Oct-4 and acetylated H4K5 in rabbit embryos
    Chien Hong Chen
    Institute of Biotechnology, National Taiwan University, Taipei, Taiwan, ROC
    Reprod Biomed Online 24:433-42. 2012
    ..These findings enrich our understanding on key genetic and epigenetic programming events during early embryo development in rabbits...
  39. ncbi request reprint Lineage differentiation-associated loss of adenoviral susceptibility and Coxsackie-adenovirus receptor expression in human mesenchymal stem cells
    Shih Chieh Hung
    Department of Orthopedics and Traumatology, Veterans General Hospital Taipei, Taipei, Taiwan
    Stem Cells 22:1321-9. 2004
    ..According to the present investigation, undifferentiated hMSCs can serve as a gene-delivering system, and gene transfer into hMSCs before differentiation can resolve the difficulties in transduction of their differentiated progeny...